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Anne-Christine Bay-Jensen

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Anne-Christine Bay-Jensen; Claus Christiansen; Morten A Karsdal; Rik Lories; Kathrine Marcher-Mikkelsen; Efstathios Vassiliadis; Stephanie Wichuk; Walter P Maksymowych
Circulating citrullinated vimentin fragments reflect disease burden in ankylosing spondylitis and have prognostic capacity for radiographic progression.
Morten A Karsdal; Mette J Nielsen; Jannie M Sand; Victoria Smith; Joanne I Adamkewicz; Anne-Christine Bay-Jensen; Claus Christiansen; Federica Genovese; Kim Henriksen; Diana J Leeming
Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure.
Pingping Chen-An; Kim Henriksen; Morten A Karsdal; Kim Vietz Andreassen; Anne-Christine Bay-Jensen
Investigation of chondrocyte hypertrophy and cartilage calcification in a full-depth articular cartilage explants model.

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2013: Anne-Christine Bay-Jensen; Claus Christiansen; Morten A Karsdal; Rik Lories; Kathrine Marcher-Mikkelsen; Efstathios Vassiliadis; Stephanie Wichuk; Walter P Maksymowych
Circulating citrullinated vimentin fragments reflect disease burden in ankylosing spondylitis and have prognostic capacity for radiographic progression.
Arthritis and rheumatism 2013;65(4):972-80.
2013: Morten A Karsdal; Mette J Nielsen; Jannie M Sand; Victoria Smith; Joanne I Adamkewicz; Anne-Christine Bay-Jensen; Claus Christiansen; Federica Genovese; Kim Henriksen; Diana J Leeming
Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure.
Assay and drug development technologies 2013;11(2):70-92.
2013: Pingping Chen-An; Kim Henriksen; Morten A Karsdal; Kim Vietz Andreassen; Anne-Christine Bay-Jensen
Investigation of chondrocyte hypertrophy and cartilage calcification in a full-depth articular cartilage explants model.
Rheumatology international 2013;33(2):401-11.
2013: Anne-Christine Bay-Jensen; Inger Byrjalsen; Claus Christiansen; Morten A Karsdal; Diana J Leeming; Nathalie Morency; Stephanie Wichuk; Walter P Maksymowych
Circulating protein fragments of cartilage and connective tissue degradation are diagnostic and prognostic markers of rheumatoid arthritis and ankylosing spondylitis.
PloS one 2013;8(1):e54504.
2012: M A Karsdal; K Henriksen; Anne-Christine Bay-Jensen; C Christiansen
The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation: may estrogen be a magic bullet?
Menopause international 2012;18(4):139-46.
2012: Anne-Christine Bay-Jensen; Arndt Kleyer; Diana J Leeming; Georg Schett; Sanne S Veidal; Morten A Karsdal
Ankylosing spondylitis is characterized by an increased turnover of several different metalloproteinase-derived collagen species: a cross-sectional study.
Rheumatology international 2012;32(11):3565-72.
2012: Morten A Karsdal; Andy Kenwright; Georg Schett; Anne-Christine Bay-Jensen; Inger Byrjalsen; Paul Emery; Olivier Harari; Adam Platt
IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT00106522).
Seminars in arthritis and rheumatism 2012;42(2):131-9.
2012: S S Veidal; Q Zheng; Anne-Christine Bay-Jensen; X Chen; D V Larsen; M R Larsen; Diana J Leeming; A Nawrocki; G Schett; S Sun; Morten A Karsdal
MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis.
Clinical biochemistry 2012;45(7-8):541-6.
2012: H Skjøt-Arkil; Y Wang; C Zhang; Q Zheng; Peter Alexandersen; Anne-Christine Bay-Jensen; Claus Christiansen; Kim Henriksen; D V Larsen; M R Larsen; Diana J Leeming; A Nawrocki; Georg Schett; M A Karsdal
Investigation of two novel biochemical markers of inflammation, matrix metalloproteinase and cathepsin generated fragments of C-reactive protein, in patients with ankylosing spondylitis.
Clinical and experimental rheumatology 2012;30(3):371-9.
2012: Bodil-Cecilie Sondergaard; Rasmus H Nielsen; S Schilling; Thorsten Schinke; Michael Amling; Anne-Christine Bay-Jensen; Philip Catala-Lehnen; M Haberland; Kim Henriksen; A K Huebner; Morten A Karsdal
Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012;20(2):136-43.
2012: Anita V Neutzsky-Wulff; Qinlong Zheng; Kim V Andreassen; Anne-Christine Bay-Jensen; Michael Feigh; Kim Henriksen; Sara T Hjuler; Morten A Karsdal
Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: how markers of β-cell loss may assist.
Journal of translational medicine 2012;10():214.
2012: Pingping Chen-An; Kim Henriksen; Morten A Karsdal; Yadong Li; Kim Vietz Andreassen; Anne-Christine Bay-Jensen
The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage.
PloS one 2012;7(6):e40081.
2012: Maria Harbo; Per Kjaersgaard-Andersen; Steen Koelvraa; Kent Søe; Thomas L Andersen; Anne-Christine Bay-Jensen; Laila Bendix; Jesper Graakjaer; Jean-Marie Delaisse
The distribution pattern of critically short telomeres in human osteoarthritic knees.
Arthritis research & therapy 2012;14(1):R12.
2011: Suzi H Madsen; Francis M Sverdrup; Morten A Karsdal; Kim V Andreassen; Anne-Christine Bay-Jensen; Søren T Christensen; Kim Henriksen
Glucocorticoids exert context-dependent effects on cells of the joint in vitro.
Steroids 2011;76(13):1474-82.
2011: Per Qvist; Bodil-Cecilie Sondergaard; Anne-Christine Bay-Jensen; Claus Christiansen; Morten A Karsdal
Molecular serum and urine marker repertoire supporting clinical research on joint diseases.
Best practice & research. Clinical rheumatology 2011;25(6):859-72.
2011: Basem M Abdallah; Anne-Christine Bay-Jensen; Jean-Marie Delaissé; Patrick Garnero; Sundeep Khosla; Bhuma Srinivasan; Nadine C Tabassi; Moustapha Kassem
Estrogen inhibits Dlk1/FA1 production: a potential mechanism for estrogen effects on bone turnover.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(10):2548-51.
2011: D J Leeming; Anne-Christine Bay-Jensen; E Vassiliadis; M R Larsen; Kim Henriksen; Morten A Karsdal
Post-translational modifications of the extracellular matrix are key events in cancer progression: opportunities for biochemical marker development.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2011;16(3):193-205.
2011: Rasmus H Nielsen; Anne-Christine Bay-Jensen; Inger Byrjalsen; Morten A Karsdal
Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2011;19(4):466-73.
2011: Anne-Christine Bay-Jensen; Qi Liu; Inger Byrjalsen; Yi Li; Jianxia Wang; Christian Pedersen; Diana J Leeming; Erik B Dam; Qinlong Zheng; Per Qvist; Morten A Karsdal
Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis.
Clinical biochemistry 2011;44(5-6):423-9.
2011: Morten A Karsdal; Kim Henriksen; Anne-Christine Bay-Jensen; B Molloy; M Arnold; M R John; Inger Byrjalsen; M Azria; B J Riis; Per Qvist; Claus Christiansen
Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials.
Journal of clinical pharmacology 2011;51(4):460-71.
2011: Toni Segovia-Silvestre; Bodil-Cecilie Sondergaard; Caroline Bonnefond; Tjorbjoern Christensen; Morten A Karsdal; Anne-Christine Bay-Jensen
Identification of the calcitonin receptor in osteoarthritic chondrocytes.
BMC research notes 2011;4():407.
2011: Morten A Karsdal; Walter P Maksymowych; Adam Platt; Per Qvist; Georg Schett; Tanja Schubert; Philippe Vergnaud; Thasia Woodworth; Claus Christiansen; Harry Genant; Kim Henriksen; Anne-Christine Bay-Jensen
Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities.
Arthritis research & therapy 2011;13(2):215.
2011: Efstathios Vassiliadis; Sanne Skovgård Veidal; Natasha Barascuk; Jhinuk Basu Mullick; Rikke Elgaard Clausen; Lise Larsen; Henrik Simonsen; Dorthe Vang Larsen; Anne-Christine Bay-Jensen; Toni Segovia-Silvestre; Diana Julie Leeming; Morten A Karsdal
Measurement of matrix metalloproteinase 9-mediated collagen type III degradation fragment as a marker of skin fibrosis.
BMC dermatology 2011;11():6.
2010: Kim Henriksen; Anne-Christine Bay-Jensen; Claus Christiansen; Morten A Karsdal
Oral salmon calcitonin--pharmacology in osteoporosis.
Expert opinion on biological therapy 2010;10(11):1617-29.
2010: Morten A Karsdal; Kim Henriksen; Diana Julie Leeming; Thasia Woodworth; Efstathios Vassiliadis; Anne-Christine Bay-Jensen
Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers--are they the cause or the consequence of the disease?
Clinical biochemistry 2010;43(10-11):793-804.
2010: Bodil-Cecilie Sondergaard; N Schultz; S H Madsen; Anne-Christine Bay-Jensen; M Kassem; Morten A Karsdal
MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(3):279-88.
2010: Per Qvist; Claus Christiansen; Morten A Karsdal; Suzi Høgh Madsen; Bodil-Cecilie Sondergaard; Anne-Christine Bay-Jensen
Application of biochemical markers in development of drugs for treatment of osteoarthritis.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2010;15(1):1-19.
2010: Anne-Christine Bay-Jensen; Suzi Hoegh-Madsen; Erik Dam; Kim Henriksen; Bodil-Cecilie Sondergaard; Philippe Pastoureau; Per Qvist; Morten A Karsdal
Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?
Rheumatology international 2010;30(4):435-42.
2010: Anne-Christine Bay-Jensen; Bodil-Cecilie Sondergaard; Claus Christiansen; Morten A Karsdal; Suzi Høgh Madsen; Per Qvist
Biochemical markers of joint tissue turnover.
Assay and drug development technologies 2010;8(1):118-24.
2010: Sanne Skovgård Veidal; Efstathios Vassiliadis; Anne-Christine Bay-Jensen; Gervais Tougas; Ben Vainer; Morten A Karsdal
Procollagen type I N-terminal propeptide (PINP) is a marker for fibrogenesis in bile duct ligation-induced fibrosis in rats.
Fibrogenesis & tissue repair 2010;3(1):5.
2010: Sanne Skovgård Veidal; Anne-Christine Bay-Jensen; Gervais Tougas; Morten A Karsdal; Ben Vainer
Serum markers of liver fibrosis: combining the BIPED classification and the neo-epitope approach in the development of new biomarkers.
Disease markers 2010;28(1):15-28.
2009: P Richardot; N Charni-Ben Tabassi; L Toh; H Marotte; Anne-Christine Bay-Jensen; P Miossec; P Garnero
Nitrated type III collagen as a biological marker of nitric oxide-mediated synovial tissue metabolism in osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(10):1362-7.
2009: Morten A Karsdal; Kim Henriksen; D J Leeming; P Mitchell; K Duffin; N Barascuk; L Klickstein; P Aggarwal; O Nemirovskiy; I Byrjalsen; Per Qvist; Anne-Christine Bay-Jensen; E B Dam; S H Madsen; Claus Christiansen
Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2009;14(3):181-202.
2009: S H Madsen; B C Sondergaard; Anne-Christine Bay-Jensen; Morten A Karsdal
Cartilage formation measured by a novel PIINP assay suggests that IGF-I does not stimulate but maintains cartilage formation ex vivo.
Scandinavian journal of rheumatology 2009;38(3):222-6.
2009: N Charni-Ben Tabassi; P Richardot; L Toh; H Marotte; Anne-Christine Bay-Jensen; P Miossec; P Garnero
Circulating nitrated N-telopeptide of type III collagen (IIINys) as a biochemical marker of oxidative-related synovial tissue metabolism in rheumatoid arthritis.
Annals of the rheumatic diseases 2009;68(3):451-2.
2009: Anne-Christine Bay-Jensen; Nadine C B Tabassi; Lene V Sondergaard; Thomas L Andersen; Frederik Dagnaes-Hansen; Patrick Garnero; Moustapha Kassem; Jean-Marie Delaissé
The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnover.
Arthritis research & therapy 2009;11(1):R9.
2008: N Charni-Ben Tabassi; S Desmarais; Anne-Christine Bay-Jensen; J M Delaissé; Michael Percival; P Garnero
The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(10):1183-91.
2008: Per Qvist; Anne-Christine Bay-Jensen; Claus Christiansen; Erik B Dam; Philippe Pastoureau; Morten A Karsdal
The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?
Pharmacological research : the official journal of the Italian Pharmacological Society 2008;58(1):1-7.
2008: Anne-Christine Bay-Jensen; T L Andersen; N Charni-Ben Tabassi; P W Kristensen; P Kjaersgaard-Andersen; L Sandell; P Garnero; J-M Delaissé
Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(5):615-23.
2002: Natalia Garcia-Giralt; Xavier Nogués; Anna Enjuanes; Jordi Puig; Leonardo Mellibovsky; Anne-Christine Bay-Jensen; Ramon Carreras; Susana Balcells; Adolfo Díez-Pérez; Daniel Grinberg
Two new single-nucleotide polymorphisms in the COL1A1 upstream regulatory region and their relationship to bone mineral density.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(3):384-93.