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Juan Botas

Research Profile

Chemicals & Drugs

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Boxun Lu; Antonio Valencia; Qiong Wang; Haidi Yang; Ismael Al-Ramahi; Frada Berenshteyn; Juan Botas; Marian DiFiglia; Tatiana Gallego-Flores; Marc Hild; Salah Ichcho; Arnaud Lacoste; James Palacino
Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance.
Maria de Haro; Jerrah K Holth; Karlie R Jones; Lubov T Timchenko; Ismael Al-Ramahi; Juan Botas
Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy.
Dyna I Shirasaki; Ismael Al-Ramahi; Pinmanee Boontheung; Juan Botas; Giovanni Coppola; Daniel H Geschwind; Michelle Gray; Erin R Greiner; Steve Horvath; Joseph A Loo; X William Yang
Network organization of the huntingtin proteomic interactome in mammalian brain.

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All Publications

2013: Boxun Lu; Antonio Valencia; Qiong Wang; Haidi Yang; Ismael Al-Ramahi; Frada Berenshteyn; Juan Botas; Marian DiFiglia; Tatiana Gallego-Flores; Marc Hild; Salah Ichcho; Arnaud Lacoste; James Palacino
Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance.
Nature neuroscience 2013;16(5):562-70.
2013: Maria de Haro; Jerrah K Holth; Karlie R Jones; Lubov T Timchenko; Ismael Al-Ramahi; Juan Botas
Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy.
PLoS genetics 2013;9(4):e1003445.
2012: Dyna I Shirasaki; Ismael Al-Ramahi; Pinmanee Boontheung; Juan Botas; Giovanni Coppola; Daniel H Geschwind; Michelle Gray; Erin R Greiner; Steve Horvath; Joseph A Loo; X William Yang
Network organization of the huntingtin proteomic interactome in mammalian brain.
Neuron 2012;75(1):41-57.
2012: Ningzhe Zhang; Ismael Al-Ramahi; Juan Botas; Xin Cong; Bradford W Gibson; Jason M Held; Eugene Kim; Bensheng Li; Lisa M Ellerby
Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.
The Journal of biological chemistry 2012;287(25):21204-13.
2012: John P Miller; Sean D Mooney; Mario Sanhueza; Cameron Torcassi; Bridget E Yates; Eugene Kim; Ismael Al-Ramahi; Ari E Berman; Juan Botas; Maria de Haro; Francesco DeGiacomo; Lisa M Ellerby; Juliette Gafni; Jennifer Holcomb; Robert E Hughes
A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.
PLoS genetics 2012;8(11):e1003042.
2010: John P Miller; Jennifer Holcomb; Ismael Al-Ramahi; Maria de Haro; Juliette Gafni; Ningzhe Zhang; Eugene Kim; Mario Sanhueza; Cameron Torcassi; Seung Kwak; Juan Botas; Robert E Hughes; Lisa M Ellerby
Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.
Neuron 2010;67(2):199-212.
2008: Oyinkan Sofola; Vasudha Sundram; Fanny Ng; Yelena Kleyner; Joannella Morales; Juan Botas; F Rob Jackson; David L Nelson
The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(41):10200-5.
2008: Joana Branco; Ismael Al-Ramahi; Lubna Ukani; Alma M Pérez; Pedro Fernandez-Funez; Diego Rincón-Limas; Juan Botas
Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.
Human molecular genetics 2008;17(3):376-90.
2008: Eliana Romero; Guang-Ho Cha; Patrik Verstreken; Cindy V Ly; Robert E Hughes; Hugo J Bellen; Juan Botas
Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.
Neuron 2008;57(1):27-40.
2008: Holly N Cukier; Alma M Perez; Ann L Collins; Zhaolan Zhou; Huda Y Zoghbi; Juan Botas
Genetic modifiers of MeCP2 function in Drosophila.
PLoS genetics 2008;4(9):e1000179.
2007: Ismael Al-Ramahi; Alma M Pérez; Janghoo Lim; Minghang Zhang; Rie Sorensen; Maria de Haro; Joana Branco; Stef pulst; Huda Y Zoghbi; Juan Botas
dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1.
PLoS genetics 2007;3(12):e234.
2007: Oyinkan A Sofola; Peng Jin; Juan Botas; David L Nelson
Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat.
Human molecular genetics 2007;16(19):2326-32.
2007: Oyinkan A Sofola; Peng Jin; Yunlong Qin; Ranhui Duan; Huijie Liu; Maria de Haro; David L Nelson; Juan Botas
RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS.
Neuron 2007;55(4):565-71.
2007: Linda S Kaltenbach; Eliana Romero; Robert R Becklin; Rakesh Chettier; Russell Bell; Amit R Phansalkar; Andrew Strand; Cameron Torcassi; Justin Savage; Anthony Hurlburt; Guang-Ho Cha; Lubna Ukani; Cindy Lou Chepanoske; Yuejun Zhen; Sudhir Sahasrabudhe; James Olson; Cornelia Kurschner; Lisa M Ellerby; John M Peltier; Juan Botas; Robert E Hughes
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
PLoS genetics 2007;3(5):e82.
2007: Juan Botas
Drosophila researchers focus on human disease.
Nature genetics 2007;39(5):589-91.
2007: Mei-Ling Qi; Kazuhiko Tagawa; Yasushi Enokido; Natsue Yoshimura; Yo-ichi Wada; Kei Watase; Sho-ichi Ishiura; Ichiro Kanazawa; Juan Botas; Minoru Saitoe; Erich E Wanker; hitoshi okazawa
Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.
Nature cell biology 2007;9(4):402-14.
2006: Yung C Lam; Aaron B Bowman; Paymaan Jafar-Nejad; Janghoo Lim; Ronald Richman; John D Fryer; Eric D Hyun; Lisa A Duvick; Harry T Orr; Juan Botas; Huda Y Zoghbi
ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.
Cell 2006;127(7):1335-47.
2006: Ismael Al-Ramahi; Yung C Lam; Hung-Kai Chen; Beatrice De Gouyon; Minghang Zhang; Alma M Pérez; Joana Branco; Maria de Haro; Winston Patterson; Huda Y Zoghbi; Juan Botas
CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.
The Journal of biological chemistry 2006;281(36):26714-24.
2006: Sebastián Kadener; Adriana Villella; Elzbieta Kula; Kristyna Palm; Elzbieta Pyza; Juan Botas; Jeffrey C Hall; Michael Rosbash
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(36):13537-42.
2006: Maria de Haro; Ismael Al-Ramahi; Beatrice De Gouyon; Lubna Ukani; Alberto Rosa; Nuno André Faustino; Tetsuo Ashizawa; Thomas A Cooper; Juan Botas
MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1.
Human molecular genetics 2006;15(13):2138-45.
2005: Hiroshi Tsuda; Hamed Jafar-Nejad; Akash J Patel; Yaling Sun; Hung-Kai Chen; Matthew F Rose; Koen J T Venken; Juan Botas; Harry T Orr; Hugo J Bellen; Huda Y Zoghbi
The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins.
Cell 2005;122(4):633-44.
2003: Hung-Kai Chen; Pedro Fernandez-Funez; Summer F Acevedo; Yung C Lam; Michael D Kaytor; Michael H Fernandez; Alastair Aitken; Efthimios M C Skoulakis; Harry T Orr; Juan Botas; Huda Y Zoghbi
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Cell 2003;113(4):457-68.
2002: Huda Y Zoghbi; Juan Botas
Mouse and fly models of neurodegeneration.
Trends in genetics : TIG 2002;18(9):463-71.
2002: Casey M Bergman; Barret D Pfeiffer; Diego E Rincón-Limas; Roger A Hoskins; Andreas Gnirke; Chris Mungall; Adrienne M Wang; Brent Kronmiller; Joanne Pacleb; Soo Park; Mark Stapleton; Ken Wan; Reed A George; Pieter J de Jong; Juan Botas; Gerald M Rubin; Susan E Celniker
Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome.
Genome biology 2002;3(12):RESEARCH0086.
2001: Maria Capovilla; Zakaria Kambris; Juan Botas
Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm.
Development (Cambridge, England) 2001;128(8):1221-30.
2000: CH Lu; Diego E Rincón-Limas; Juan Botas
Conserved overlapping and reciprocal expression of msh/Msx1 and apterous/Lhx2 in Drosophila and mice.
Mechanisms of development 2000;99(1-2):177-81.
2000: Pedro Fernandez-Funez; M L Nino-Rosales; Beatrice De Gouyon; Wei-Chi She; J M Luchak; P Martinez; E Turiegano; J Benito; Maria Capovilla; Pamela J Skinner; AE McCall; Inmaculada Canal; Harry T Orr; Huda Y Zoghbi; Juan Botas
Identification of genes that modify ataxin-1-induced neurodegeneration.
Nature 2000;408(6808):101-6.
2000: Diego E Rincón-Limas; CH Lu; Inmaculada Canal; Juan Botas
The level of DLDB/CHIP controls the activity of the LIM homeodomain protein apterous: evidence for a functional tetramer complex in vivo.
The EMBO journal 2000;19(11):2602-14.
1999: Brenda J Lilly; David D. O'Keefe; John B Thomas; Juan Botas
The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila.
Mechanisms of development 1999;88(2):195-205.
1999: Diego E Rincón-Limas; CH Lu; Inmaculada Canal; M Calleja; Concepción Rodríguez Esteban; Juan Carlos Izpisúa Belmonte; Juan Botas
Conservation of the expression and function of apterous orthologs in Drosophila and mammals.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2165-70.
1998: Pedro Fernandez-Funez; CH Lu; Diego E Rincón-Limas; A García-Bellido; Juan Botas
The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing.
The EMBO journal 1998;17(23):6846-53.
1998: Maria Capovilla; Juan Botas
Functional dominance among Hox genes: repression dominates activation in the regulation of Dpp.
Development (Cambridge, England) 1998;125(24):4949-57.
1998: Concepcion Rodriguez-Esteban; John W R Schwabe; J D Peña; D E Rincon-Limas; J Magallón; Juan Botas; J C Izpisúa Belmonte
Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth.
Development (Cambridge, England) 1998;125(20):3925-34.
1998: Andrew J Bendall; Diego E Rincón-Limas; Juan Botas; Cory Abate-Shen
Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity.
Differentiation; research in biological diversity 1998;63(3):151-7.
1997: H Stanley; Juan Botas; V Malhotra
The mechanism of Golgi segregation during mitosis is cell type-specific.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14467-70.
1996: Juan Botas; L Auwers
Chromosomal binding sites of Ultrabithorax homeotic proteins.
Mechanisms of development 1996;56(1-2):129-38.
1994: Siu-Kwong Chan; L Jaffe; M Capovilla; Juan Botas; Richard S Mann
The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein.
Cell 1994;78(4):603-15.
1994: H Drexler; T A Fischell; Fausto J Pinto; Adrian Chenzbraun; Juan Botas; john cooke; Edwin L Alderman
Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Relation to vessel wall morphology.
Circulation 1994;89(4):1615-23.
1994: Juan Botas; D A Clark; Fausto J Pinto; Adrian Chenzbraun; T A Fischell
Balloon angioplasty results in increased segmental coronary distensibility: a likely mechanism of percutaneous transluminal coronary angioplasty.
Journal of the American College of Cardiology 1994;23(5):1043-52.
1994: E Eldon; S Kooyer; D D'Evelyn; M Duman; P Lawinger; Juan Botas; Hugo J Bellen
The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll.
Development (Cambridge, England) 1994;120(4):885-99.
1994: M Capovilla; M Brandt; Juan Botas
Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis.
Cell 1994;76(3):461-75.
1993: Juan Botas
Control of morphogenesis and differentiation by HOM/Hox genes.
Current opinion in cell biology 1993;5(6):1015-22.
1993: K D Irvine; Juan Botas; S Jha; Richard S Mann; David S Hogness
Negative autoregulation by Ultrabithorax controls the level and pattern of its expression.
Development (Cambridge, England) 1993;117(1):387-99.
1992: G Vachon; B Cohen; C Pfeifle; M E McGuffin; Juan Botas; S M Cohen
Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less.
Cell 1992;71(3):437-50.
1983: Ginés Morata; Juan Botas; S Kerridge; G Struhl
Homeotic transformations of the abdominal segments of Drosophila caused by breaking or deleting a central portion of the bithorax complex.
Journal of embryology and experimental morphology 1983;78():319-41.
1982: Juan Botas; J Moscoso del Prado; A García-Bellido
Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila.
The EMBO journal 1982;1(3):307-10.