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Gregory M. Cole

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Edmond Teng; Stephen P Trusko; Fusheng Yang; Ping-Ping Chen; Graham B Cole; Gregory M. Cole; Dorothy G Flood; Sally A Frautschy; Sung-Cheng Huang; Mychica R Jones; Vladimir Kepe; Jie Liu; Nagichettiar Satyamurthy; Gary W Small; Jorge R Barrio
[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment.
Gregory M. Cole; Qiu-Lan Ma; Sally A Frautschy
Dietary fatty acids and the aging brain.
Sally A Frautschy; Gregory M. Cole
Why pleiotropic interventions are needed for Alzheimer's disease.

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All Publications

2011: Edmond Teng; Stephen P Trusko; Fusheng Yang; Ping-Ping Chen; Graham B Cole; Gregory M. Cole; Dorothy G Flood; Sally A Frautschy; Sung-Cheng Huang; Mychica R Jones; Vladimir Kepe; Jie Liu; Nagichettiar Satyamurthy; Gary W Small; Jorge R Barrio
[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment.
Neurobiology of disease 2011;43(3):565-75.
2010: Gregory M. Cole; Qiu-Lan Ma; Sally A Frautschy
Dietary fatty acids and the aging brain.
Nutrition reviews 2010;68 Suppl 2():S102-11.
2010: Sally A Frautschy; Gregory M. Cole
Why pleiotropic interventions are needed for Alzheimer's disease.
Molecular neurobiology 2010;41(2-3):392-409.
2010: Gregory M. Cole; Sally A Frautschy
DHA may prevent age-related dementia.
The Journal of nutrition 2010;140(4):869-74.
2009: James Joseph; Gregory M. Cole; Elizabeth Head; Donald Ingram
Nutrition, brain aging, and neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(41):12795-801.
2009: Gregory M. Cole; qiulan ma; Sally A Frautschy
Omega-3 fatty acids and dementia.
Prostaglandins, leukotrienes, and essential fatty acids 2009;81(2-3):213-21.
2009: qiulan ma; Fusheng Yang; Emily R Rosario; Oliver J Ubeda; Walter Beech; Dana J Gant; Ping Ping Chen; Beverly Hudspeth; Cory Chen; Yongle Zhao; Harry V Vinters; Sally A Frautschy; Gregory M. Cole
Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(28):9078-89.
2009: Linda M Ercoli; Prabha Siddarth; Vladimir Kepe; Karen J Miller; Sung-Cheng Huang; Gregory M. Cole; Helen Lavretsky; Susan Y Bookheimer; Jeanne Kim; Michael E Phelps; Jorge R Barrio; Gary W Small
Differential FDDNP PET patterns in nondemented middle-aged and older adults.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2009;17(5):397-406.
2009: qiulan ma; Douglas Galasko; John M Ringman; Harry V Vinters; Steven D Edland; Justine Pomakian; Oliver J Ubeda; Emily R Rosario; Bruce Teter; Sally A Frautschy; Gregory M. Cole
Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid.
Archives of neurology 2009;66(4):448-57.
2009: Shuxin Hu; Aynun N Begum; Mychica R Jones; Mike S Oh; Walter K Beech; Beverly Hudspeth Beech; Fusheng Yang; Pingping Chen; Oliver J Ubeda; Peter C Kim; Peter Davies; qiulan ma; Gregory M. Cole; Sally A Frautschy
GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals.
Neurobiology of disease 2009;33(2):193-206.
2009: Gary W Small; Prabha Siddarth; Alison C Burggren; Vladimir Kepe; Linda M Ercoli; Karen J Miller; Helen Lavretsky; Paul M Thompson; Gregory M. Cole; S C Huang; Michael E Phelps; Susan Y Bookheimer; Jorge R Barrio
Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia.
Archives of general psychiatry 2009;66(1):81-7.
2008: Aynun N Begum; Fusheng Yang; Edmond Teng; Shuxin Hu; Mychica R Jones; Emily R Rosario; Walter Beech; Beverly Hudspeth; Oliver J Ubeda; Gregory M. Cole; Sally A Frautschy
Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model.
Journal of Alzheimer's disease : JAD 2008;15(4):625-40.
2008: John M Ringman; Steven G Younkin; Domenico Pratico'; W Seltzer; Gregory M. Cole; Daniel Geschwind; Y Rodriguez-Agudelo; B Schaffer; J Fein; S Sokolow; E R Rosario; Karen H Gylys; Arousiak Varpetian; L D Medina; Jeffrey L Cummings
Biochemical markers in persons with preclinical familial Alzheimer disease.
Neurology 2008;71(2):85-92.
2008: Aynun N Begum; Mychica R Jones; Giselle P Lim; Takashi Morihara; Peter Kim; Dennis D Heath; Cheryl L Rock; Mila A Pruitt; Fusheng Yang; Beverly Hudspeth; Shuxin Hu; Kym F Faull; Bruce Teter; Gregory M. Cole; Sally A Frautschy
Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease.
The Journal of pharmacology and experimental therapeutics 2008;326(1):196-208.
2008: Jeffrey A Fein; Sophie Sokolow; Carol A Miller; Harry V Vinters; Fusheng Yang; Gregory M. Cole; Karen H Gylys
Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes.
The American journal of pathology 2008;172(6):1683-92.
2008: qiulan ma; Fusheng Yang; Frederic Calon; Oliver J Ubeda; James E Hansen; Richard H Weisbart; Walter Beech; Sally A Frautschy; Gregory M. Cole
p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis.
The Journal of biological chemistry 2008;283(20):14132-43.
2008: Linda Kotilinek; Marcus A Westerman; Qinwen Wang; Kimberly Panizzon; Giselle P Lim; Agnes Simonyi; Sylvain Lesne; Agnieszka Falinska; Linda Younkin; Steven G Younkin; Michael Rowan; James P Cleary; Roi Ann Wallis; Grace Y Sun; Gregory M. Cole; Sally Frautschy; Roger Anwyl; Karen K. Hsiao Ashe
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity.
Brain : a journal of neurology 2008;131(Pt 3):651-64.
2008: Gary W Small; Susan Y Bookheimer; Paul M Thompson; Gregory M. Cole; S-C Huang; Vladimir Kepe; Jorge R Barrio
Current and future uses of neuroimaging for cognitively impaired patients.
Lancet neurology 2008;7(2):161-72.
2007: qiulan ma; Bruce Teter; Oliver J Ubeda; Takashi Morihara; Dilsher Dhoot; Michael D Nyby; Michael L Tuck; Sally A Frautschy; Gregory M. Cole
Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(52):14299-307.
2007: Frederic Calon; Gregory M. Cole
Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies.
Prostaglandins, leukotrienes, and essential fatty acids 2007;77(5-6):287-93.
2007: qiulan ma; Marni E Harris-White; Oliver J Ubeda; Mychica Simmons; Walter Beech; Giselle P Lim; Bruce Teter; Sally A Frautschy; Gregory M. Cole
Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models.
Journal of neurochemistry 2007;103(4):1594-607.
2007: Gregory M. Cole; Bruce Teter; Sally A Frautschy
Neuroprotective effects of curcumin.
Advances in experimental medicine and biology 2007;595():197-212.
2007: Gregory M. Cole; Sally A Frautschy
The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease.
Experimental gerontology 2007;42(1-2):10-21.
2007: Karen H Gylys; Jeffrey A Fein; Fusheng Yang; Carol A Miller; Gregory M. Cole
Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex.
Neurobiology of aging 2007;28(1):8-17.
2006: Gary W Small; Vladimir Kepe; Linda M Ercoli; Prabha Siddarth; Susan Y Bookheimer; Karen J Miller; Helen Lavretsky; Alison C Burggren; Gregory M. Cole; Harry V Vinters; Paul M Thompson; Sung-Cheng Huang; Nagichettiar Satyamurthy; Michael E Phelps; Jorge R Barrio
PET of brain amyloid and tau in mild cognitive impairment.
The New England journal of medicine 2006;355(25):2652-63.
2006: Gregory M. Cole; Sally A Frautschy
Commentary on "Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery." Pleiotropic approaches to Alzheimer's and other diseases of aging.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(4):284-6.
2006: Gregory M. Cole; Sally A Frautschy
Cat and mouse.
Neuron 2006;51(6):671-2.
2006: Gregory M. Cole; Sally A Frautschy
Alzheimer's amyloid story finds its star.
Trends in molecular medicine 2006;12(9):395-6.
2006: Gregory M. Cole
A transgenic triple scores a home run.
Nature medicine 2006;12(7):762-3; discussion 763.
2006: qiulan ma; Giselle P Lim; Marni E Harris-White; Fusheng Yang; Surendra S Ambegaokar; Oliver J Ubeda; Charles G Glabe; Bruce Teter; Sally A Frautschy; Gregory M. Cole
Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.
Journal of neuroscience research 2006;83(3):374-84.
2006: Lixia Zhao; qiulan ma; Frederic Calon; Marni E Harris-White; Fusheng Yang; Giselle P Lim; Takashi Morihara; Oliver J Ubeda; Surendra Ambegaokar; James E Hansen; Richard H Weisbart; Bruce Teter; Sally A Frautschy; Gregory M. Cole
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.
Nature neuroscience 2006;9(2):234-42.
2006: Vladimir Kepe; Jorge R Barrio; Sung-Cheng Huang; Linda M Ercoli; Prabha Siddarth; Kooresh Shoghi-Jadid; Gregory M. Cole; Nagichettiar Satyamurthy; Jeffrey L Cummings; Gary W Small; Michael E Phelps
Serotonin 1A receptors in the living brain of Alzheimer's disease patients.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(3):702-7.
2006: Gregory M. Cole; Sally A Frautschy
Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model.
Nutrition and health 2006;18(3):249-59.
2005: Gregory M. Cole; Giselle P Lim; Fusheng Yang; Bruce Teter; Aynun N Begum; qiulan ma; Marni E Harris-White; Sally A Frautschy
Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions.
Neurobiology of aging 2005;26 Suppl 1():133-6.
2005: Frederic Calon; Giselle P Lim; Takashi Morihara; Fusheng Yang; Oliver J Ubeda; Norman Salem; Sally A Frautschy; Gregory M. Cole
Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease.
The European journal of neuroscience 2005;22(3):617-26.
2005: Takashi Morihara; Bruce Teter; Fusheng Yang; Giselle P Lim; Sally Boudinot; F Douglas Boudinot; Sally A Frautschy; Gregory M. Cole
Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(6):1111-20.
2005: John M Ringman; Sally A Frautschy; Gregory M. Cole; Donna Masterman; Jeffrey L Cummings
A potential role of the curry spice curcumin in Alzheimer's disease.
Current Alzheimer research 2005;2(2):131-6.
2005: Giselle P Lim; Frederic Calon; Takashi Morihara; Fusheng Yang; Bruce Teter; Oliver J Ubeda; Norman Salem; Sally A Frautschy; Gregory M. Cole
A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(12):3032-40.
2005: Fusheng Yang; Giselle P Lim; Aynun N Begum; Oliver J Ubeda; Mychica R Simmons; Surendra S Ambegaokar; Pingping P Chen; Rakez Kayed; Charles G Glabe; Sally A Frautschy; Gregory M. Cole
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
The Journal of biological chemistry 2005;280(7):5892-901.
2004: Lixia Zhao; Bruce Teter; Takashi Morihara; Giselle P Lim; Surendra S Ambegaokar; Oliver J Ubeda; Sally A Frautschy; Gregory M. Cole
Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(49):11120-6.
2004: Gregory M. Cole; Takashi Morihara; Giselle P Lim; Fusheng Yang; Aynun N Begum; Sally A Frautschy
NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models.
Annals of the New York Academy of Sciences 2004;1035():68-84.
2004: Richard H Weisbart; James E Hansen; Grace Chan; Rika Wakelin; Sophia S Chang; Emil Heinze; Carl W Miller; Phillip H Koeffler; Fusheng Yang; Gregory M. Cole; Yoon S Min; Robert N Nishimura
Antibody-mediated transduction of p53 selectively kills cancer cells.
International journal of oncology 2004;25(6):1867-73.
2004: Karen H Gylys; Jeffrey A Fein; Fusheng Yang; Dorothy J Wiley; Carol A Miller; Gregory M. Cole
Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence.
The American journal of pathology 2004;165(5):1809-17.
2004: Frederic Calon; Giselle P Lim; Fusheng Yang; Takashi Morihara; Bruce Teter; Oliver J Ubeda; Phillippe Rostaing; Antoine Triller; Norman Salem; Karen K. Hsiao Ashe; Sally A Frautschy; Gregory M. Cole
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model.
Neuron 2004;43(5):633-45.
2004: Karen H Gylys; Jeffrey A Fein; Fusheng Yang; Gregory M. Cole
Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004;60(1):90-6.
2004: Michael R D'Andrea; Gregory M. Cole; March Ard
The microglial phagocytic role with specific plaque types in the Alzheimer disease brain.
Neurobiology of aging 2004;25(5):675-83.
2004: Karen H Gylys; Jeffrey A Fein; Dorothy J Wiley; Gregory M. Cole
Rapid annexin-V labeling in synaptosomes.
Neurochemistry international 2004;44(3):125-31.
2003: Gregory M. Cole
Ironic fate: can a banned drug control metal heavies in neurodegenerative diseases?
Neuron 2003;37(6):889-90.
2003: Richard H Weisbart; Fusheng Yang; Grace Chan; Rika Wakelin; Kevin Ferreri; Debra Zack; Brooke Harrison; Leslie A Leinwand; Gregory M. Cole
Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb.
Molecular immunology 2003;39(13):783-9.
2003: Karen H Gylys; Jeffrey A Fein; Aiko M Tan; Gregory M. Cole
Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals.
Journal of neurochemistry 2003;84(6):1442-51.
2003: Eric Agdeppa; Vladimir Kepe; A Petri; Nagichettiar Satyamurthy; Jie Liu; Sung-Cheng Huang; Gary W Small; Gregory M. Cole; Jorge R Barrio
In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile.
Neuroscience 2003;117(3):723-30.
2002: Masanori Tomioka; Keiro Shirotani; Nobuhisa Iwata; Hahn-Jun Lee; Fusheng Yang; Gregory M. Cole; Yousuke Seyama; Takaomi C Saido
In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons.
Brain research. Molecular brain research 2002;108(1-2):18-32.
2002: Takashi Morihara; Teresa Chu; Oliver J Ubeda; Walter Beech; Gregory M. Cole
Selective inhibition of Abeta42 production by NSAID R-enantiomers.
Journal of neurochemistry 2002;83(4):1009-12.
2002: Karen H Gylys; Jeffrey A Fein; Gregory M. Cole
Caspase inhibition protects nerve terminals from in vitro degradation.
Neurochemical research 2002;27(6):465-72.
2002: Jeffrey L Cummings; Gregory M. Cole
Alzheimer disease.
JAMA : the journal of the American Medical Association 2002;287(18):2335-8.
2002: Bruce Teter; Pu-Ting Xu; John Gilbert; Allen D Roses; Douglas Galasko; Gregory M. Cole
Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function.
Journal of neuroscience research 2002;68(3):331-6.
2002: Xiaoyan Sun; Gregory M. Cole; Teresa Chu; Weiming Xia; Douglas Galasko; Haruyasu Yamaguchi; Kentaro Tanemura; Sally A Frautschy; Akihiko Takashima
Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines.
Neurobiology of aging 2002;23(2):195-203.
2002: JP Rossiter; L L Anderson; F Yang; Gregory M. Cole
Caspase-3 activation and caspase-like proteolytic activity in human perinatal hypoxic-ischemic brain injury.
Acta neuropathologica 2002;103(1):66-73.
2001: Eric Agdeppa; Vladimir Kepe; Jie Liu; S Flores-Torres; Nagichettiar Satyamurthy; Andrej Petric; Gregory M. Cole; Gary W Small; Sung-Cheng Huang; Jorge R Barrio
Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(24):RC189.
2001: E Bertrand; E Brouillet; I Caillé; Colette Bouillot; Gregory M. Cole; Alain Prochiantz; Bernadette Allinquant
A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo.
Molecular and cellular neurosciences 2001;18(5):503-11.
2001: Sally A Frautschy; W Hu; P Kim; S A Miller; Teresa Chu; Marni E Harris-White; Gregory M. Cole
Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology.
Neurobiology of aging 2001;22(6):993-1005.
2001: Giselle P Lim; Fusheng Yang; Teresa Chu; Ethan Gahtan; Oliver J Ubeda; Walter Beech; J Bruce Overmier; K Hsiao-Ashec; Sally A Frautschy; Gregory M. Cole
Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice.
Neurobiology of aging 2001;22(6):983-91.
2001: Giselle P Lim; Teresa Chu; Fusheng Yang; Walter Beech; Sally A Frautschy; Gregory M. Cole
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(21):8370-7.
2001: Marni E Harris-White; Teresa Chu; S A Miller; M Simmons; Bruce Teter; D Nash; Gregory M. Cole; Sally A Frautschy
Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo.
Neurochemistry international 2001;39(5-6):435-48.
2001: Emil Adamec; F Yang; Gregory M. Cole; Ralph A. Nixon
Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration.
Brain research. Brain research protocols 2001;7(3):193-202.
2001: T A Chen; F Yang; Gregory M. Cole; Sun-On Chan
Inhibition of caspase-3-like activity reduces glutamate induced cell death in adult rat retina.
Brain research 2001;904(1):177-88.
2001: Gregory M. Cole; Sally A Frautschy
Church baptizes Joseph and Perry. Eccentric views absolved.
Neurobiology of aging 2001;22(1):147-50; discussion 161-3.
2000: Rudolf A de Boer; Dirk J van Veldhuisen; J van der Wijk; R M Brouwer; N de Jonge; Gregory M. Cole; Albert J H Suurmeijer
Additional use of immunostaining for active caspase 3 and cleaved actin and PARP fragments to detect apoptosis in patients with chronic heart failure.
Journal of cardiac failure 2000;6(4):330-7.
2000: Gregory M. Cole; March Ard
Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein.
Microscopy research and technique 2000;50(4):316-24.
2000: JP Rossiter; L L Anderson; F Yang; Gregory M. Cole
Caspase-cleaved actin (fractin) immunolabelling of Hirano bodies.
Neuropathology and applied neurobiology 2000;26(4):342-6.
2000: Giselle P Lim; Fusheng Yang; Teresa Chu; P Chen; Walter Beech; Bruce Teter; T Tran; Oliver J Ubeda; Karen K. Hsiao Ashe; Sally A Frautschy; Gregory M. Cole
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(15):5709-14.
2000: Karen H Gylys; Jeffrey A Fein; Gregory M. Cole
Quantitative characterization of crude synaptosomal fraction (P-2) components by flow cytometry.
Journal of neuroscience research 2000;61(2):186-92.
2000: S Lankiewicz; C Marc Luetjens; N Truc Bui; AJ Krohn; Monika Poppe; Gregory M. Cole; Takaomi C Saido; Jochen H M Prehn
Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death.
The Journal of biological chemistry 2000;275(22):17064-71.
2000: Haruhiko Akiyama; Steven W Barger; S Barnum; B Bradt; J Bauer; Gregory M. Cole; N R Cooper; Piet Eikelenboom; M Emmerling; B L Fiebich; Caleb E Finch; S Frautschy; W S Griffin; Harald Hampel; M Hull; Gary Landreth; Lih-Fen Lue; R Mrak; I R Mackenzie; Patrick L McGeer; M K O'Banion; Joel S. Pachter; Giulio Maria Pasinetti; C Plata-Salaman; Joseph Rogers; R Rydel; Yong Shen; W Streit; R Strohmeyer; I Tooyoma; F L Van Muiswinkel; R Veerhuis; Douglas G. Walker; S Webster; B Wegrzyniak; Gary L Wenk; Tony Wyss-Coray
Inflammation and Alzheimer's disease.
Neurobiology of aging 2000;21(3):383-421.
2000: Mark O McCarron; Nicoll James; J Stewart; Gregory M. Cole; F Yang; JW Ironside; D M A Mann; S Love; DI Graham
Amyloid beta-protein length and cerebral amyloid angiopathy-related haemorrhage.
Neuroreport 2000;11(5):937-40.
2000: Karen Horsburgh; Gregory M. Cole; F Yang; Mary J Savage; Barry D Greenberg; Stephen M Gentleman; David I Graham; Nicoll James
beta-amyloid (Abeta)42(43), abeta42, abeta40 and apoE immunostaining of plaques in fatal head injury.
Neuropathology and applied neurobiology 2000;26(2):124-32.
2000: Fusheng Yang; Kenji Uéda; P Chen; Karen K. Hsiao Ashe; Gregory M. Cole
Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein.
Brain research 2000;853(2):381-3.
1999: Bruce Teter; Pu-Ting Xu; John Gilbert; Allen D Roses; Douglas Galasko; Gregory M. Cole
Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture.
Journal of neurochemistry 1999;73(6):2613-6.
1999: Michael S Mega; Teresa Chu; John C Mazziotta; K H Trivedi; Paul M Thompson; A Shah; Gregory M. Cole; Sally A Frautschy; Arthur W Toga
Mapping biochemistry to metabolism: FDG-PET and amyloid burden in Alzheimer's disease.
Neuroreport 1999;10(14):2911-7.
1999: Gregory M. Cole; Walter Beech; Sally A Frautschy; JJ Sigel; C Glasgow; March Ard
Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro.
Journal of neuroscience research 1999;57(4):504-20.
1999: Albert J H Suurmeijer; J van der Wijk; D J van Veldhuisen; F Yang; Gregory M. Cole
Fractin immunostaining for the detection of apoptotic cells and apoptotic bodies in formalin-fixed and paraffin-embedded tissue.
Laboratory investigation; a journal of technical methods and pathology 1999;79(5):619-20.
1999: M Walton; Bronwen Connor; Patricia A Lawlor; Deborah Young; Ernest Sirimanne; Peter D Gluckman; Gregory M. Cole; Michael Dragunow
Neuronal death and survival in two models of hypoxic-ischemic brain damage.
Brain research. Brain research reviews 1999;29(2-3):137-68.
1999: Bruce Teter; Marni E Harris-White; Sally A Frautschy; Gregory M. Cole
Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures.
Neuroscience 1999;91(3):1009-16.
1998: M R Pulera; L M Adams; H Liu; D G Santos; Robert N Nishimura; Fusheng Yang; Gregory M. Cole; Claude Wasterlain
Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia.
Stroke; a journal of cerebral circulation 1998;29(12):2622-30.
1998: Sally A Frautschy; D L Horn; JJ Sigel; Marni E Harris-White; J J Mendoza; Fusheng Yang; Takaomi C Saido; Gregory M. Cole
Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8311-21.
1998: Teresa Chu; T Tran; Fusheng Yang; Walter Beech; Gregory M. Cole; Sally A Frautschy
Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line.
FEBS letters 1998;436(3):439-44.
1998: Jeffrey L Cummings; Harry V Vinters; Gregory M. Cole; ZAVEN KHACHATURIAN
Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities.
Neurology 1998;51(1 Suppl 1):S2-17; discussion S65-7.
1998: Fusheng Yang; X Sun; Walter Beech; Bruce Teter; S Wu; JJ Sigel; Harry V Vinters; Sally A Frautschy; Gregory M. Cole
Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease.
The American journal of pathology 1998;152(2):379-89.
1998: Sally A Frautschy; Fusheng Yang; M Irrizarry; Bradley T Hyman; Takaomi C Saido; Karen K. Hsiao Ashe; Gregory M. Cole
Microglial response to amyloid plaques in APPsw transgenic mice.
The American journal of pathology 1998;152(1):307-17.
1996: Karen K. Hsiao Ashe; P Chapman; S Nilsen; Christopher B Eckman; Y Harigaya; Steven G Younkin; F Yang; Gregory M. Cole
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.
Science (New York, N.Y.) 1996;274(5284):99-102.
1996: Brian John Cummings; T Satou; Elizabeth Head; Norton W Milgram; Gregory M. Cole; Mary J Savage; M B Podlisny; Dennis J Selkoe; R Siman; Benjamin D Greenberg; Carl W Cotman
Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs.
Neurobiology of aging 1996;17(4):653-9.
1996: Sally A Frautschy; F Yang; L Calderón; Gregory M. Cole
Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits.
Neurobiology of aging 1996;17(2):311-21.
1996: TL Tekirian; Gregory M. Cole; M J Russell; F Yang; David R Wekstein; E Patel; David A Snowdon; William R Markesbery; James W Geddes
Carboxy terminal of beta-amyloid deposits in aged human, canine, and polar bear brains.
Neurobiology of aging 1996;17(2):249-57.
1996: March Ard; Gregory M. Cole; J Wei; A P Mehrle; Jonathan D Fratkin
Scavenging of Alzheimer's amyloid beta-protein by microglia in culture.
Journal of neuroscience research 1996;43(2):190-202.
1994: K Mak; F Yang; Harry V Vinters; Sally A Frautschy; Gregory M. Cole
Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum.
Brain research 1994;667(1):138-42.
1994: F Yang; K Mak; Harry V Vinters; Sally A Frautschy; Gregory M. Cole
Monoclonal antibody to the C-terminus of beta-amyloid.
Neuroreport 1994;5(16):2117-20.
1994: Elliott J Mufson; W C Benzing; Gregory M. Cole; H Wang; D F Emerich; J R Sladek; J H Morrison; Jeffrey Kordower
Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex: colocalization with amyloid plaques.
Neurobiology of aging 1994;15(5):621-7.
1994: Jürgen Winkler; Donald Connor; Sally A Frautschy; Christian Behl; Jerene J Waite; Gregory M. Cole; Leon J Thal
Lack of long-term effects after beta-amyloid protein injections in rat brain.
Neurobiology of aging 1994;15(5):601-7.
1994: Gregory M. Cole; Jim W Neal; William I Fraser; V A Cowie
Autopsy findings in patients with mental handicap.
Journal of intellectual disability research : JIDR 1994;38 ( Pt 1)():9-26.
1993: Gregory M. Cole; Jim W Neal; Sim K Singhrao; Bharat Jasani; Geoffrey R Newman
The distribution of amyloid plaques in the cerebellum and brain stem in Down's syndrome and Alzheimer's disease: a light microscopical analysis.
Acta neuropathologica 1993;85(5):542-52.
1992: Gregory M. Cole; L Bell; Q B Truong; T Saitoh
An endosomal-lysosomal pathway for degradation of amyloid precursor protein.
Annals of the New York Academy of Sciences 1992;674():103-17.
1992: Jerene J Waite; Gregory M. Cole; Sally A Frautschy; Donald Connor; Leon J Thal
Solvent effects on beta protein toxicity in vivo.
Neurobiology of aging 1992;13(5):595-9.
1992: Christian Behl; J Davis; Gregory M. Cole; David Schubert
Vitamin E protects nerve cells from amyloid beta protein toxicity.
Biochemical and biophysical research communications 1992;186(2):944-50.
1992: Sally A Frautschy; Gregory M. Cole; Andrew Baird
Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid.
The American journal of pathology 1992;140(6):1389-99.
1992: Jim W Neal; E M Cave; Sim K Singhrao; Gregory M. Cole; Sheila J Wallace
Alexander's disease in infancy and childhood: a report of two cases.
Acta neuropathologica 1992;84(3):322-7.
1991: David E Stone; Gregory M. Cole; M de Barros Lopes; M Goebl; Steven I Reed
N-myristoylation is required for function of the pheromone-responsive G alpha protein of yeast: conditional activation of the pheromone response by a temperature-sensitive N-myristoyl transferase.
Genes & development 1991;5(11):1969-81.
1991: Sally A Frautschy; Andrew Baird; Gregory M. Cole
Effects of injected Alzheimer beta-amyloid cores in rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8362-6.
1991: Eliezer Masliah; Gregory M. Cole; Lawrence A Hansen; Margaret Mallory; T Albright; R D Terry; T Saitoh
Protein kinase C alteration is an early biochemical marker in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(9):2759-67.
1991: Jim W Neal; R C Pearson; Gregory M. Cole; T P Powell
Neuronal hypertrophy in the pars reticulata of the substantia nigra in Parkinson's disease.
Neuropathology and applied neurobiology 1991;17(3):203-6.
1991: T Saitoh; Eliezer Masliah; Lee-Way Jin; Gregory M. Cole; T Wieloch; I P Shapiro
Protein kinases and phosphorylation in neurologic disorders and cell death.
Laboratory investigation; a journal of technical methods and pathology 1991;64(5):596-616.
1991: Gregory M. Cole; Eliezer Masliah; Earl R Shelton; H W Chan; R D Terry; T Saitoh
Accumulation of amyloid precursor fragment in Alzheimer plaques.
Neurobiology of aging 1991;12(2):85-91.
1991: Gregory M. Cole; S I Reed
Pheromone-induced phosphorylation of a G protein beta subunit in S. cerevisiae is associated with an adaptive response to mating pheromone.
Cell 1991;64(4):703-16.
1990: Gregory M. Cole; Douglas Galasko; I P Shapiro; T Saitoh
Stimulated platelets release amyloid beta-protein precursor.
Biochemical and biophysical research communications 1990;170(1):288-95.
1990: Eliezer Masliah; Gregory M. Cole; Shun Shimohama; Lawrence A Hansen; R DeTeresa; R D Terry; T Saitoh
Differential involvement of protein kinase C isozymes in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(7):2113-24.
1990: F G Klier; Gregory M. Cole; W Stallcup; David Schubert
Amyloid beta-protein precursor is associated with extracellular matrix.
Brain research 1990;515(1-2):336-42.
1990: Sim K Singhrao; Gregory M. Cole; W J Henderson; Geoffrey R Newman
LR White embedding allows a multi-method approach to the analysis of brain tissue from patients with Alzheimer's disease.
The Histochemical journal 1990;22(5):257-68.
1990: Gregory M. Cole; David E Stone; Steven I Reed
Stoichiometry of G protein subunits affects the Saccharomyces cerevisiae mating pheromone signal transduction pathway.
Molecular and cellular biology 1990;10(2):510-7.
1990: T Saitoh; Gregory M. Cole; T V Huynh
Aberrant protein kinase C cascades in Alzheimer's disease.
Advances in experimental medicine and biology 1990;265():301-10.
1990: H Sternberg; G Mesco; Gregory M. Cole; P S Timiras
Tau protein: its presence and metabolism in human neuroblastoma cells.
Advances in experimental medicine and biology 1990;265():283-9.
1989: David Schubert; Lee-Way Jin; T Saitoh; Gregory M. Cole
The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion.
Neuron 1989;3(6):689-94.
1989: T Van Huynh; Gregory M. Cole; Robert Katzman; K P Huang; T Saitoh
Reduced protein kinase C immunoreactivity and altered protein phosphorylation in Alzheimer's disease fibroblasts.
Archives of neurology 1989;46(11):1195-9.
1989: P D Kushner; D T Stephenson; S Wright; Gregory M. Cole; C M Greco
Monoclonal antibody Tor 23 binds a subset of neural cells in the human cortex and displays an altered binding distribution in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1989;48(6):692-708.
1989: Gregory M. Cole; T V Huynh; T Saitoh
Evidence for lysosomal processing of amyloid beta-protein precursor in cultured cells.
Neurochemical research 1989;14(10):933-9.
1989: T Saitoh; M Sundsmo; J M Roch; N Kimura; Gregory M. Cole; David Schubert; Tilman Oltersdorf; Dale Schenk
Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.
Cell 1989;58(4):615-22.
1989: Gregory M. Cole; R K Mortimer
Failure to induce a DNA repair gene, RAD54, in Saccharomyces cerevisiae does not affect DNA repair or recombination phenotypes.
Molecular and cellular biology 1989;9(8):3314-22.
1989: David Schubert; Gregory M. Cole; T Saitoh; Tilman Oltersdorf
Amyloid beta protein precursor is a mitogen.
Biochemical and biophysical research communications 1989;162(1):83-8.
1989: Gregory M. Cole; P Williams; D Alldryck; S Singharo
Amyloid plaques in the cerebellum in Alzheimer's disease.
Clinical neuropathology 1989;8(4):188-91.
1989: Gregory M. Cole; D Schild; R K Mortimer
Two DNA repair and recombination genes in Saccharomyces cerevisiae, RAD52 and RAD54, are induced during meiosis.
Molecular and cellular biology 1989;9(7):3101-4.
1989: Gregory M. Cole; Eliezer Masliah; T V Huynh; R DeTeresa; R D Terry; C Okuda; T Saitoh
An antiserum against amyloid beta-protein precursor detects a unique peptide in Alzheimer brain.
Neuroscience letters 1989;100(1-3):340-6.
1989: K Uéda; Gregory M. Cole; M Sundsmo; Robert Katzman; T Saitoh
Decreased adhesiveness of Alzheimer's disease fibroblasts: is amyloid beta-protein precursor involved?
Annals of neurology 1989;25(3):246-51.
1989: David Schubert; M LaCorbiere; T Saitoh; Gregory M. Cole
Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(6):2066-9.
1988: David Schubert; R Schroeder; M LaCorbiere; T Saitoh; Gregory M. Cole
Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein.
Science (New York, N.Y.) 1988;241(4862):223-6.
1988: S Love; T Saitoh; S Quijada; Gregory M. Cole; R D Terry
Alz-50, ubiquitin and tau immunoreactivity of neurofibrillary tangles, Pick bodies and Lewy bodies.
Journal of neuropathology and experimental neurology 1988;47(4):393-405.
1988: Gregory M. Cole; Karen R Dobkins; Lawrence A Hansen; R D Terry; T Saitoh
Decreased levels of protein kinase C in Alzheimer brain.
Brain research 1988;452(1-2):165-74.
1988: H Sternberg; J Baudier; K Akizuki; Gregory M. Cole; W H Martin; C E Creutz; P S Timiras; R David Cole
Similarities and differences between tau protein and chromobindin A.
Neurochemistry international 1988;13(2):149-52.
1987: P D Kushner; Gregory M. Cole; H Sternberg; P I Woloshin
A human teratocarcinoma which expresses a rare neuronal cell surface antigen.
Brain research 1987;388(3):271-5.
1987: Gregory M. Cole; P S Timiras
Ubiquitin-protein conjugates in Alzheimer's lesions.
Neuroscience letters 1987;79(1-2):207-12.
1987: Gregory M. Cole; D Schild; Susan T Lovett; R K Mortimer
Regulation of RAD54- and RAD52-lacZ gene fusions in Saccharomyces cerevisiae in response to DNA damage.
Molecular and cellular biology 1987;7(3):1078-84.
1986: M Ino; Gregory M. Cole; P S Timiras
Tyrosine hydroxylase and monoamine oxidase-A activity increases in differentiating human neuroblastoma after elimination of dividing cells.
Brain research 1986;395(1):120-3.
1986: Edgar F Meyer; R Radhakrishnan; Gregory M. Cole; L G Presta
Structure of the product complex of acetyl-Ala-Pro-Ala with porcine pancreatic elastase at 1.65 A resolution.
Journal of molecular biology 1986;189(3):533-9.
1978: Gregory M. Cole; J F Taintor; G A James
Endodontic therapy of a dilated dens invaginatus.
Journal of endodontics 1978;4(3):88-90.