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Bart De Strooper

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Ina Tesseur; Marta Ciesielska; Joris De Maeyer; Rudi D'Hooge; Stefan F Lichtenthaler; Adrian C Lo; Anna A Pimenova; Jan A J Schuurkes; Bart De Strooper
Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.
Lore Delbroek; Kris Gevaert; Wim Mandemakers; Dario R Alessi; Raquel da Cunha; Guy Daneels; Pieter-Jan De Bock; Bart De Strooper; Liesbeth Steegmans; Kristof Van Kolen; Patrik Verstreken; Jinwei Zhang; Dieder Moechars
Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation.
S Ali M Shariati; Bart De Strooper; Carlos G Dotti; Bassem A Hassan; Pierre Lau; Ulrike Müller; Annette Gärtner
APLP2 regulates neuronal stem cell differentiation during cortical development.

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2013: Ina Tesseur; Marta Ciesielska; Joris De Maeyer; Rudi D'Hooge; Stefan F Lichtenthaler; Adrian C Lo; Anna A Pimenova; Jan A J Schuurkes; Bart De Strooper
Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice.
Neurobiology of aging 2013;34(7):1779-89.
2013: Lore Delbroek; Kris Gevaert; Wim Mandemakers; Dario R Alessi; Raquel da Cunha; Guy Daneels; Pieter-Jan De Bock; Bart De Strooper; Liesbeth Steegmans; Kristof Van Kolen; Patrik Verstreken; Jinwei Zhang; Dieder Moechars
Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation.
Journal of pharmaceutical and biomedical analysis 2013;76():49-58.
2013: S Ali M Shariati; Bart De Strooper; Carlos G Dotti; Bassem A Hassan; Pierre Lau; Ulrike Müller; Annette Gärtner
APLP2 regulates neuronal stem cell differentiation during cortical development.
Journal of cell science 2013;126(Pt 5):1268-77.
2013: Amantha Thathiah; Elke Vandewyer; Marta Ciesielska; Gerdien De Kloe; Katrien Horré; Yunhong Huang; Sebastian Munck; An Snellinx; Bart De Strooper
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.
Nature medicine 2013;19(1):43-9.
2012: Wim Mandemakers; Michael J O'Neill; An Snellinx; Bart De Strooper
LRRK2 expression is enriched in the striosomal compartment of mouse striatum.
Neurobiology of disease 2012;48(3):582-93.
2012: Tomas Borgegård; Bart De Strooper; Susanne Gustavsson; Shaobo Jin; Anders Juréus; Helena Karlström; Rebecka Klintenberg; Urban Lendahl; Johan Lund; Asa Malmberg; Charlotte Nilsson; Fredrik Olsson; Santiago Parpal; Anna Ridderstad-Wollberg; Susanne Rosqvist; Lutgarde Serneels; Kenneth Stockling; Samuel Svensson; Johanna Wanngren; Patrik Wollberg; Hongmei Yan; Per I Arvidsson; Anna-Lena Berg; Johan Lundkvist
Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(48):17297-305.
2012: Bart De Strooper; LUCA SCORRANO
Close encounter: mitochondria, endoplasmic reticulum and Alzheimer's disease.
The EMBO journal 2012;31(21):4095-7.
2012: Annelies Vandersteen; Iryna Benilova; Greet De Baets; Bart De Strooper; Wim Jonckheere; Siewert J Marrink; Marcelo F Masman; Frederic Rousseau; Jef Rozenski; Joost Schymkowitz; Vinod Subramaniam; Kees van der Werf; Kerensa Broersen
Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool.
The Journal of biological chemistry 2012;287(44):36732-43.
2012: Samer Matta; Katarzyna Miskiewicz; Dieder Moechars; Vanessa A Morais; Jef Swerts; Geert van den Bogaart; Kristof Van Kolen; Lucía Chávez-Gutiérrez; Raquel da Cunha; Guy Daneels; Pieter-Jan De Bock; Bart De Strooper; Lore Delbroek; Giovanni Esposito; Kris Gevaert; Dominik Haddad; Matthew Holt; Eric Karran; Wim Mandemakers; Sven Vilain; Patrik Verstreken
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.
Neuron 2012;75(6):1008-21.
2012: Jun Cai; Zhijuan Chen; Bart De Strooper; Alonso Emilio; Todd Golde; Maria B Grant; Song Han; Antonia M Joussen; Norbert Kociok; Li Liu; Xiaoping Qi; Qing Ruan; Paul Saftig; Lutgarde Serneels; Sergej Skosyrski; Catherine Bowes Rickman; Michael E Boulton
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
EMBO molecular medicine 2012;4(9):980-91.
2012: Cary Esselens; Rodrigo Gallardo; Daniela Kaden; Johannes P M Langedijk; Gerd Multhaup; Frederic Rousseau; Ragna Sannerud; Joost Schymkowitz; Lutgarde Serneels; Veerle Baert; Bart De Strooper; Willem ANNAERT
Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(9):3765-78.
2012: Bart De Strooper; Thierry Voet
Alzheimer's disease: A protective mutation.
Nature 2012;488(7409):38-9.
2012: Lujia Zhou; Kris Gevaert; Wim Annaert; Soraia Barão; Katrijn Bockstael; Marianne Borgers; Kris Gevaer; Harry Gijsen; Mathias Laga; Marc Mercken; Diederik Moechars; Bart De Strooper
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.
The Journal of biological chemistry 2012;287(31):25927-40.
2012: Francesc X Guix; Gerard Ill-Raga; Alberto Lleó; Francisco J Muñoz; Eva Ramos-Fernandez; An Snellinx; Krist'l Vennekens; Tina Wahle; Muriel Arimon; Oksana Berezovska; Lucía Chávez-Gutiérrez; Carlos G Dotti; Cristina Guardia-Laguarta; Bart De Strooper
Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.
EMBO molecular medicine 2012;4(7):660-73.
2012: Ilya Bezprozvanny; Suya Sun; Charlene Supnet; Hua Zhang; Bart De Strooper
Response to Shilling et al. (10.1074/jbc.M111.300491).
The Journal of biological chemistry 2012;287(24):20469; author reply 20470.
2012: Melissa Vos; Sven Vilain; Bart De Strooper; Janaka N Edirisinghe; Giovanni Esposito; Dominik M Haddad; R Meganathan; Vanessa A Morais; Onno Schaap; Jan R Slabbaert; Stefanie Van Meensel; Patrik Verstreken
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency.
Science (New York, N.Y.) 2012;336(6086):1306-10.
2012: Jonathan Brouillette; Claire Alves-Pires; Iryna Benilova; David Blum; Raphaëlle Caillierez; Bart De Strooper; Nadège Zommer; Luc BUEE
Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(23):7852-61.
2012: Peter Carmeliet; Bart De Strooper
Alzheimer's disease: A breach in the blood-brain barrier.
Nature 2012;485(7399):451-2.
2012: Lucía Chávez-Gutiérrez; Leen Bammens; Iryna Benilova; Manasi Benurwar; Marianne Borgers; Kerensa Broersen; Hermann Esselmann; Harrie Gijsen; Eric Karran; Sam Lismont; Frederic Rousseau; Joost Schymkowitz; Lutgarde Serneels; Simon Van Cleynenbreugel; Annelies Vandersteen; Jens Wiltfang; Lujia Zhou; Bart De Strooper
The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.
The EMBO journal 2012;31(10):2261-74.
2012: Iryna Benilova; Eric Karran; Bart De Strooper
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes.
Nature neuroscience 2012;15(3):349-57.
2012: Evgenia Salta; Bart De Strooper
Non-coding RNAs with essential roles in neurodegenerative disorders.
Lancet neurology 2012;11(2):189-200.
2012: Aikaterini S Papadopoulou; Wim Pierson; Olga Ucar; Saulius Zuklys; Bart De Strooper; James Dooley; Daniel H D Gray; Georg A Hollander; Bruno Kyewski; Michelle A Linterman; Patrick Matthys; Adrian Liston
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.
Nature immunology 2012;13(2):181-7.
2012: Kathryn Rogers; Louise Scrocchi; Gideon Shapiro; Darcie Spaulding; Zhiming Tu; Veerle Vulsteke; Melody Wen; Zhiyong Yang; Henrik Zetterberg; Michael Ahlijanian; Faris Albayya; Jean-Francois Blain; Richard Chesworth; Don Costa; Bart De Strooper; Kevin M Felsenstein; Dorothy Flood; Emily Freeman; Daniel Havas; Hilliary Hodgdon; Sarah Hopp; Lori Hrdlicka; Birgit Hutter-Paier; Winnie Lee; Liza Leventhal; Mary-Jo Miller; Scott Nolan; Holger Patzke; Erik Portelius; Gerhard Koenig
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.
Molecular neurodegeneration 2012;7():61.
2012: Bart De Strooper; Takeshi Iwatsubo; Michael S Wolfe
Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.
Cold Spring Harbor perspectives in medicine 2012;2(1):a006304.
2011: Seon-Ah Chong; Bart De Strooper; Herman Devijver; Wolfgang Eberle; Dieder Moechars; Hamdy Shaban; Fred Van Leuven; Carmen Bartic; Iryna Benilova; Geert Callewaert
Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study.
Neurobiology of disease 2011;44(3):284-91.
2011: Marcia L Moss; Robert Petrovich; Gary Powell; Bin Qi; Qing-Xiang Amy Sang; Uwe Schlomann; Mara Taverna; Ina Tesseur; Julia Li Zhong; Pei Zhou; Bart De Strooper; Colin Dingwall; Lori Edwards; Taheera Ferdous; Linda G Griffith; Douglas A Lauffenburger; Stefan F Lichtenthaler; Miles A Miller; Joerg Walter Bartsch
ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
The Journal of biological chemistry 2011;286(47):40443-51.
2011: Sabine Rabe; Julia Reichwald; Paul Saftig; Domenico Ammaturo; Bart De Strooper; Ulf Neumann; Matthias Staufenbiel
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
Journal of neurochemistry 2011;119(1):231-9.
2011: Ragna Sannerud; Giampietro Schiavo; Baert Veerle; Lujia Zhou; Katrijn Coen; Bart De Strooper; Ilse Declerck; Guillermo Menendez; Sebastian Munck; Aleksandar Peric; Tim Raemaekers; Wim Annaert
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):E559-68.
2011: Iryna Benilova; Bart De Strooper
An overlooked neurotoxic species in Alzheimer's disease.
Nature neuroscience 2011;14(8):949-50.
2011: Krzysztof Glomski; Katia Manova-Todorova; Sébastien Monette; Paul Saftig; Bart De Strooper; Carl P Blobel
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.
Blood 2011;118(4):1163-74.
2011: Omar Nelson; Charlene Supnet; Alexandra Tolia; Bart De Strooper; Katrien Horré; Ilya Bezprozvanny
Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.
The Journal of biological chemistry 2011;286(25):22339-47.
2011: Lujia Zhou; Nathalie Brouwers; Iryna Benilova; Annelies Vandersteen; Marc Mercken; Koen Van Laere; Philip Van Damme; David Demedts; Fred Van Leuven; Kristel Sleegers; Kerensa Broersen; Christine Van Broeckhoven; Rik Vandenberghe; Bart De Strooper
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.
EMBO molecular medicine 2011;3(5):291-302.
2011: Henry Brodaty; Monique Breteler; Steven T DeKosky; Pascale Dorenlot; Laura Fratiglioni; Christoph Hock; Paul-Ariel Kenigsberg; Philip scheltens; Bart De Strooper
The world of dementia beyond 2020.
Journal of the American Geriatrics Society 2011;59(5):923-7.
2011: Leen Bammens; Lucía Chávez-Gutiérrez; Alexandra Tolia; An Zwijsen; Bart De Strooper
Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.
The Journal of biological chemistry 2011;286(14):12271-82.
2011: Lujia Zhou; Lucia Chávez-Gutiérrez; Katrijn Bockstael; Ragna Sannerud; Wim Annaert; Patrick C May; Eric Karran; Bart De Strooper
Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.
The Journal of biological chemistry 2011;286(10):8677-87.
2011: Amantha Thathiah; Bart De Strooper
The role of G protein-coupled receptors in the pathology of Alzheimer's disease.
Nature reviews. Neuroscience 2011;12(2):73-87.
2011: Silvio Weber; Michaela T Niessen; Johannes Prox; Renate Lüllmann-Rauch; Annika Schmitz; Ralf Schwanbeck; Carl P Blobel; Ellen Jorissen; Bart De Strooper; Carien M Niessen; Paul Saftig
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.
Development (Cambridge, England) 2011;138(3):495-505.
2011: Deepak B Thimiri Govinda Raj; Dieter Vanderschaeghe; Etienne Waelkens; Pieter Baatsen; Murali Bagadi; Gustaaf Borghs; Nico Callewaert; Katrijn Coen; Bart De Strooper; Rita Derua; Kris Gevaert; Bart Ghesquière; Evelien Rysman; Johan Swinnen; Arun Kumar Tharkeshwar; Wim Annaert
A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes.
Molecular systems biology 2011;7():541.
2011: Hermann C Altmeppen; Udo Bartsch; Christian Bernreuther; Bart De Strooper; Ellen Jorissen; Mark A Kluth; Bettina Petrowitz; Johannes Prox; Berta Puig; Paul Saftig; Dana Thurm; Markus Glatzel
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo.
Molecular neurodegeneration 2011;6():36.
2011: Randall Bateman; Bart De Strooper; Nick C Fox; Cynthia A Lemere; John M Ringman; Stephen Salloway; Reisa A Sperling; Manfred Windisch; Paul S Aisen; Chengjie Xiong
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease.
Alzheimer's research & therapy 2011;3(1):1.
2010: Sébastien S Hébert; Aikaterini S Papadopoulou; Pascal Smith; Marie-Christine Galas; Emmanuel Planel; Asli N Silahtaroglu; Nicolas Sergeant; Luc BUEE; Bart De Strooper
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration.
Human molecular genetics 2010;19(20):3959-69.
2010: Inna Kuperstein; Kerensa Broersen; Iryna Benilova; Jef Rozenski; Wim Jonckheere; Maja Debulpaep; Annelies Vandersteen; Ine Segers-Nolten; Kees Van Der Werf; Vinod Subramaniam; Dries Braeken; Geert Callewaert; Carmen Bartic; Rudi D'Hooge; Ivo Cristiano Martins; Frederic Rousseau; Joost Schymkowitz; Bart De Strooper
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
The EMBO journal 2010;29(19):3408-20.
2010: Pierre Lau; Bart De Strooper
Dysregulated microRNAs in neurodegenerative disorders.
Seminars in cell & developmental biology 2010;21(7):768-73.
2010: Iryna Benilova; Bart De Strooper
Prion protein in Alzheimer's pathogenesis: a hot and controversial issue.
EMBO molecular medicine 2010;2(8):289-90.
2010: Bart De Strooper
Cancer and neurodegeneration meet.
EMBO molecular medicine 2010;2(7):245-6.
2010: Willem ANNAERT; Bart De Strooper
Alzheimer's disease neurons fail the acid test.
Cell 2010;141(7):1112-4.
2010: Hua Zhang; Suya Sun; An Herreman; Bart De Strooper; Ilya Bezprozvanny
Role of presenilins in neuronal calcium homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(25):8566-80.
2010: Ellen Jorissen; Johannes Prox; Christian Bernreuther; Silvio Weber; Ralf Schwanbeck; Lutgarde Serneels; An Snellinx; Katleen Craessaerts; Amantha Thathiah; Ina Tesseur; Udo Bartsch; Gisela Weskamp; Carl P Blobel; Markus Glatzel; Bart De Strooper; Paul Saftig
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(14):4833-44.
2010: Bart De Strooper
Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.
Physiological reviews 2010;90(2):465-94.
2010: Bruno A Bergmans; S Ali M Shariati; Ron L P Habets; Patrik Verstreken; Luc Schoonjans; Ulrike Müller; Carlos G Dotti; Bart De Strooper
Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation.
Stem cells (Dayton, Ohio) 2010;28(3):399-406.
2010: Bart De Strooper; Robert Vassar; todd golde
The secretases: enzymes with therapeutic potential in Alzheimer disease.
Nature reviews. Neurology 2010;6(2):99-107.
2010: Bruno A Bergmans; Bart De Strooper
gamma-secretases: from cell biology to therapeutic strategies.
Lancet neurology 2010;9(2):215-26.
2010: Ellen Jorissen; Bart De Strooper
Gamma-secretase and the intramembrane proteolysis of Notch.
Current topics in developmental biology 2010;92():201-30.
2010: Bart De Strooper; Willem ANNAERT
Novel research horizons for presenilins and γ-secretases in cell biology and disease.
Annual review of cell and developmental biology 2010;26():235-60.
2010: Vanessa A Morais; Bart De Strooper
Mitochondria dysfunction and neurodegenerative disorders: cause or consequence.
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2():S255-63.
2009: Sandra Huysseune; Pascal Kienlen-Campard; Sébastien Hébert; Bernadette Tasiaux; Karelle Leroy; Olivier Devuyst; Jean-Pierre Brion; Bart De Strooper; Jean-Noël Octave
Epigenetic control of aquaporin 1 expression by the amyloid precursor protein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(12):4158-67.
2009: Tomoko Wakabayashi; Katleen Craessaerts; Leen Bammens; Mostafa Bentahir; Filip Borgions; Piet Herdewijn; An Staes; Evy Timmerman; Joël Vandekerckhove; Eric Rubinstein; Claude Boucheix; Kris Gevaert; Bart De Strooper
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains.
Nature cell biology 2009;11(11):1340-6.
2009: Zoltan Ferjentsik; Shinichi Hayashi; J Kim Dale; Yasumasa Bessho; An Herreman; Bart De Strooper; Gonzalo del Monte; Jose Luis de la Pompa; Miguel Maroto
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.
PLoS genetics 2009;5(9):e1000662.
2009: Vanessa A Morais; Patrik Verstreken; Anne Roethig; Joél Smet; An Snellinx; Mieke Vanbrabant; Dominik Haddad; Christian Frezza; Wim Mandemakers; Daniela Vogt Weisenhorn; Rudy Van Coster; Wolfgang Wurst; LUCA SCORRANO; Bart De Strooper
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function.
EMBO molecular medicine 2009;1(2):99-111.
2009: Lutgarde Serneels; Jérôme Van Biervliet; Katleen Craessaerts; Tim Dejaegere; Katrien Horré; Tine Van Houtvin; Hermann Esselmann; Sabine Paul; Martin K Schäfer; Oksana Berezovska; Bradley T Hyman; Ben Sprangers; Raf Sciot; Lieve Moons; Mathias Jucker; Zhixiang Yang; Patrick May; Eric Karran; Jens Wiltfang; Rudi D'Hooge; Bart De Strooper
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Science (New York, N.Y.) 2009;324(5927):639-42.
2009: Francesc X Guix; Gerard Ill-Raga; Ramona Bravo; Tadashi Nakaya; Gianni De Fabritiis; Mireia Coma; Gian Pietro Miscione; Jordi Villà-Freixa; Toshiharu Suzuki; Xavier Fernàndez-Busquets; Miguel A Valverde; Bart De Strooper; Francisco J Muñoz
Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.
Brain : a journal of neurology 2009;132(Pt 5):1335-45.
2009: Thomas Tousseyn; Amantha Thathiah; Ellen Jorissen; Tim Raemaekers; Uwe Konietzko; Karina Reiss; Elke Maes; An Snellinx; Lutgarde Serneels; Omar Nyabi; Willem ANNAERT; Paul Saftig; Dieter Hartmann; Bart De Strooper
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase.
The Journal of biological chemistry 2009;284(17):11738-47.
2009: Sébastien S Hébert; Bart De Strooper
Alterations of the microRNA network cause neurodegenerative disease.
Trends in neurosciences 2009;32(4):199-206.
2009: Alexandra Tolia; Bart De Strooper
Structure and function of gamma-secretase.
Seminars in cell & developmental biology 2009;20(2):211-8.
2009: Sébastien S Hébert; Katrien Horré; Laura Nicolaï; Bruno Bergmans; Aikaterini S Papadopoulou; André Delacourte; Bart De Strooper
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.
Neurobiology of disease 2009;33(3):422-8.
2009: Amantha Thathiah; Kurt Spittaels; Marcel Hoffmann; Mik Staes; Adrian Cohen; Katrién Horré; Mieke Vanbrabant; Frea Coun; Veerle Baekelandt; André Delacourte; David F Fischer; Dirk Pollet; Bart De Strooper; Pascal Merchiers
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.
Science (New York, N.Y.) 2009;323(5916):946-51.
2009: Carlos G Dotti; Bart De Strooper
Alzheimer's dementia by circulation disorders: when trees hide the forest.
Nature cell biology 2009;11(2):114-6.
2009: Amantha Thathiah; Bart De Strooper
G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease.
Science signaling 2009;2(93):re8.
2008: Tracy O'Connor; Katherine R Sadleir; Erika Maus; rod velliquette; Jie Zhao; Sarah L Cole; William A Eimer; Brian Hitt; Leslie A Bembinster; Sven Lammich; Stefan F Lichtenthaler; Sébastien S Hébert; Bart De Strooper; Christian Haass; David A Bennett; Robert Vassar
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
Neuron 2008;60(6):988-1009.
2008: Irfan Y Tamboli; Kai Prager; Dietmar R Thal; Karin M Thelen; Ilse Dewachter; Claus U Pietrzik; Peter St George-Hyslop; Sangram S Sisodia; Bart De Strooper; Michael T Heneka; Mikhail A Filippov; Ulrike Müller; Fred Van Leuven; Dieter Lütjohann; Jochen Walter
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(46):12097-106.
2008: Tomoko Wakabayashi; Bart De Strooper
Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
Physiology (Bethesda, Md.) 2008;23():194-204.
2008: Elaine Waldron; Simone Isbert; Andreas Kern; Sebastian Jaeger; Anne M Martin; Sébastien S Hébert; Christian Behl; Sascha Weggen; Bart De Strooper; Claus U Pietrzik
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.
Experimental cell research 2008;314(13):2419-33.
2008: Lucía Chávez-Gutiérrez; Alexandra Tolia; Elke Maes; Tong Li; Philip C Wong; Bart De Strooper
Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.
The Journal of biological chemistry 2008;283(29):20096-105.
2008: T Dejaegere; L Serneels; M K Schäfer; J Van Biervliet; K Horré; C Depboylu; Daniel Alvarez Fischer; A Herreman; M Willem; Christian Haass; G U Höglinger; R D'Hooge; Bart De Strooper
Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9775-80.
2008: Alexandra Tolia; Katrien Horré; Bart De Strooper
Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase.
The Journal of biological chemistry 2008;283(28):19793-803.
2008: Sébastien S Hébert; Katrien Horré; Laura Nicolaï; Aikaterini S Papadopoulou; Wim Mandemakers; Asli N Silahtaroglu; Sakari Kauppinen; André Delacourte; Bart De Strooper
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6415-20.
2008: Ivo Cristiano Martins; Inna Kuperstein; Hannah R Wilkinson; Elke Maes; Mieke Vanbrabant; Wim Jonckheere; Patrick Van Gelder; Dieter Hartmann; Rudi D'Hooge; Bart De Strooper; Joost Schymkowitz; Frederic Rousseau
Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice.
The EMBO journal 2008;27(1):224-33.
2007: Bruno P Imbimbo; Elda Del Giudice; Davide Colavito; Antonello D'Arrigo; Maurizio Dalle Carbonare; Gino Villetti; Fabrizio Facchinetti; Roberta Volta; Vladimiro Pietrini; Maria F Baroc; Lutgarde Serneels; Bart De Strooper; alberta leon
1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
The Journal of pharmacology and experimental therapeutics 2007;323(3):822-30.
2007: Toru Sato; Thekla S Diehl; Saravanakumar Narayanan; Satoru Funamoto; Yasuo Ihara; Bart De Strooper; Harald Steiner; Christian Haass; Michael S Wolfe
Active gamma-secretase complexes contain only one of each component.
The Journal of biological chemistry 2007;282(47):33985-93.
2007: Sébastien S Hébert; Bart De Strooper
Molecular biology. miRNAs in neurodegeneration.
Science (New York, N.Y.) 2007;317(5842):1179-80.
2007: Wim Mandemakers; Vanessa A Morais; Bart De Strooper
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases.
Journal of cell science 2007;120(Pt 10):1707-16.
2007: Omar Nelson; Huiping Tu; Tianhua Lei; Mostafa Bentahir; Bart De Strooper; Ilya Bezprozvanny
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.
The Journal of clinical investigation 2007;117(5):1230-9.
2007: Marc Schulte; Karina Reiss; Marcus Lettau; Thorsten Maretzky; Andreas Ludwig; Dieter Hartmann; Bart De Strooper; Ottmar Janssen; Paul Saftig
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.
Cell death and differentiation 2007;14(5):1040-9.
2007: Peer-Hendrik Kuhn; Els Marjaux; Axel imhof; Bart De Strooper; Christian Haass; Stefan F Lichtenthaler
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase.
The Journal of biological chemistry 2007;282(16):11982-95.
2007: Bart De Strooper
Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.
EMBO reports 2007;8(2):141-6.
2006: Alexandra Tolia; Lucía Chávez-Gutiérrez; Bart De Strooper
Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.
The Journal of biological chemistry 2006;281(37):27633-42.
2006: Huiping Tu; Omar Nelson; Arseny Bezprozvanny; Zhengnan Wang; Sheu-Fen Lee; Yi-Heng Hao; Lutgarde Serneels; Bart De Strooper; Gang G. Yu; Ilya Bezprozvanny
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.
Cell 2006;126(5):981-93.
2006: Dragana Spasic; Alexandra Tolia; Katleen Dillen; Veerle Baert; Bart De Strooper; Stefan Vrijens; Willem ANNAERT
Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway.
The Journal of biological chemistry 2006;281(36):26569-77.
2006: Jessie Theuns; Els Marjaux; Mathieu Vandenbulcke; K Van Laere; Samir Kumar-Singh; G Bormans; Nathalie Brouwers; Marleen Van den Broeck; Krist'l Vennekens; Ellen Corsmit; Marc Cruts; Bart De Strooper; Christine Van Broeckhoven; Rik Vandenberghe
Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment.
Human mutation 2006;27(9):888-96.
2006: Christian Frezza; Sara Cipolat; Olga Martins de Brito; Massimo Micaroni; Galina V Beznoussenko; T Rudka; Davide Bartoli; Roman S Polishuck; Nika N Danial; Bart De Strooper; LUCA SCORRANO
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.
Cell 2006;126(1):177-89.
2006: Sara Cipolat; T Rudka; Dieter Hartmann; Veronica Costa; Lutgarde Serneels; Katleen Craessaerts; Kristine Metzger; Christian Frezza; Willem ANNAERT; Luciano D'Adamio; Carmen Derks; Tim Dejaegere; Luca Pellegrini; Rudi D'Hooge; LUCA SCORRANO; Bart De Strooper
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.
Cell 2006;126(1):163-75.
2006: Jesús Avila; Roger M Nitsch; Christian Haass; Bart De Strooper
European Alzheimer disease funding.
Nature medicine 2006;12(7):776-7.
2006: Sébastien S Hébert; Lutgarde Serneels; Alexandra Tolia; Katleen Craessaerts; Carmen Derks; Mikhail A Filippov; Ulrike Müller; Bart De Strooper
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes.
EMBO reports 2006;7(7):739-45.
2006: Sophie Debrock; Bart De Strooper; Sarah Vander Perre; Joseph A Hill; Thomas M D'Hooghe
Tumour necrosis factor-alpha, interleukin-6 and interleukin-8 do not promote adhesion of human endometrial epithelial cells to mesothelial cells in a quantitative in vitro model.
Human reproduction (Oxford, England) 2006;21(3):605-9.
2006: Mostafa Bentahir; Omar Nyabi; Jan Verhamme; Alexandra Tolia; Katrien Horré; Jens Wiltfang; Hermann Esselmann; Bart De Strooper
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Journal of neurochemistry 2006;96(3):732-42.
2005: Constanze Reinhard; Sébastien S Hébert; Bart De Strooper
The amyloid-beta precursor protein: integrating structure with biological function.
The EMBO journal 2005;24(23):3996-4006.
2005: Marcus Otto Walter Grimm; Heike S Grimm; Andreas J Pätzold; Eva G Zinser; Riikka Halonen; Marco Duering; Jakob Tschaepe; Bart De Strooper; Ulrike Müller; Jie Shen; Tobias Hartmann
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin.
Nature cell biology 2005;7(11):1118-23.
2005: Diana-Ines Dominguez; Jos Tournoy; Dieter Hartmann; Tobias Huth; Kim Cryns; Siska Deforce; Lutgarde Serneels; Ira Espuny Camacho; Els Marjaux; Katleen Craessaerts; Anton J M Roebroek; Michael Schwake; Rudi D'Hooge; Patricia Bach; Ulrich Kalinke; Dieder Moechars; Christian Alzheimer; Karina Reiss; Paul Saftig; Bart De Strooper
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.
The Journal of biological chemistry 2005;280(35):30797-806.
2005: Maarten Leyssen; Derya Ayaz; Sébastien S Hébert; Simon P Reeve; Bart De Strooper; Bassem A Hassan
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain.
The EMBO journal 2005;24(16):2944-55.
2005: Bart De Strooper
Nicastrin: gatekeeper of the gamma-secretase complex.
Cell 2005;122(3):318-20.
2005: Thorsten Maretzky; Karina Reiss; Andreas Ludwig; Julian Buchholz; Felix Scholz; Ehrhardt Proksch; Bart De Strooper; Dieter Hartmann; Paul Saftig
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9182-7.
2005: Hon Kit Wong; Takashi Sakurai; Fumitaka Oyama; Kumi Kaneko; Koji Wada; Haruko Miyazaki; Masaru Kurosawa; Bart De Strooper; Paul Saftig; Nobuyuki Nukina
beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.
The Journal of biological chemistry 2005;280(24):23009-17.
2005: Yoshifumi Nakaya; Takuya Yamane; Hirohisa Shiraishi; Hua-Qin Wang; Etsuro Matsubara; Toru Sato; Georgia Dolios; Rong Wang; Bart De Strooper; Mikio Shoji; Hiroto Komano; Katsuhiko Yanagisawa; Yasuo Ihara; Paul E Fraser; Peter St George-Hyslop; Masaki Nishimura
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.
The Journal of biological chemistry 2005;280(19):19070-7.
2005: Stacey S Huppert; Ma Xenia G Ilagan; Bart De Strooper; Raphael Kopan
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.
Developmental cell 2005;8(5):677-88.
2005: Karina Reiss; Thorsten Maretzky; Andreas Ludwig; Thomas Tousseyn; Bart De Strooper; Dieter Hartmann; Paul Saftig
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.
The EMBO journal 2005;24(4):742-52.
2005: Marcel Coolen; Karen van Loo; Nick N H M Van Bakel; David J Pulford; Lutgarde Serneels; Bart De Strooper; Bart Ellenbroek; Alexander R Cools; Gerard J M Martens
Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders.
Neuron 2005;45(4):497-503.
2005: Lutgarde Serneels; Tim Dejaegere; Katleen Craessaerts; Katrien Horré; Ellen Jorissen; Thomas Tousseyn; Sébastien S Hébert; Marcel Coolen; Gerard Martens; An Zwijsen; Willem ANNAERT; Dieter Hartmann; Bart De Strooper
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1719-24.
2004: José Abad-Rodríguez; Maria Dolores Ledesma; Katleen Craessaerts; Simona Perga; Miguel Medina; André Delacourte; Colin Dingwall; Bart De Strooper; Carlos G Dotti
Neuronal membrane cholesterol loss enhances amyloid peptide generation.
The Journal of cell biology 2004;167(5):953-60.
2004: Ira Espuny Camacho; Lutgarde Serneels; Kurt Spittaels; Pascal Merchiers; Diana-Ines Dominguez; Bart De Strooper
Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(48):10908-17.
2004: Sébastien S Hébert; Lutgarde Serneels; Tim Dejaegere; Katrien Horré; Michal Dabrowski; Veerle Baert; Willem ANNAERT; Dieter Hartmann; Bart De Strooper
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.
Neurobiology of disease 2004;17(2):260-72.
2004: Valérie Wilquet; Bart De Strooper
Amyloid-beta precursor protein processing in neurodegeneration.
Current opinion in neurobiology 2004;14(5):582-8.
2004: Cary Esselens; Viola Oorschot; Veerle Baert; Tim Raemaekers; Kurt Spittaels; Lutgarde Serneels; Hui Zheng; Paul Saftig; Bart De Strooper; Judith Klumperman; Willem ANNAERT
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
The Journal of cell biology 2004;166(7):1041-54.
2004: Amy M Nichols; Yonghua Pan; An Herreman; Brandon K Hadland; Bart De Strooper; Raphael Kopan; Stacey S Huppert
Notch pathway is dispensable for adipocyte specification.
Genesis (New York, N.Y. : 2000) 2004;40(1):40-4.
2004: Jonathan D J Wrigley; Emma J Nunn; Omar Nyabi; Earl E Clarke; Peter Hunt; Alan Nadin; Bart De Strooper; Mark S Shearman; Dirk Beher
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
Journal of neurochemistry 2004;90(6):1312-20.
2004: Jos Tournoy; Xavier Bossuyt; An Snellinx; Marleen Regent; Marian Garmyn; Lutgarde Serneels; Paul Saftig; Katleen Craessaerts; Bart De Strooper; Dieter Hartmann
Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Human molecular genetics 2004;13(13):1321-31.
2004: Osamu Nagano; Daizo Murakami; Dieter Hartmann; Bart De Strooper; Paul Saftig; Takeshi Iwatsubo; Motowo Nakajima; Masanori Shinohara; Hideyuki Saya
Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.
The Journal of cell biology 2004;165(6):893-902.
2004: Yoichi Araki; Naomi Miyagi; Naoko Kato; Tomohiro Yoshida; Sachiyo Wada; Masaki Nishimura; Hiroto Komano; Tohru Yamamoto; Bart De Strooper; Kazuo Yamamoto; Toshiharu Suzuki
Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.
The Journal of biological chemistry 2004;279(23):24343-54.
2004: Els Marjaux; Dieter Hartmann; Bart De Strooper
Presenilins in memory, Alzheimer's disease, and therapy.
Neuron 2004;42(2):189-92.
2004: Diana-Ines Dominguez; Dieter Hartmann; Bart De Strooper
BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease.
Neuro-degenerative diseases 2004;1(4-5):168-74.
2004: Tim Dejaegere; Bart De Strooper
[Secretases as therapeutic targets for the treatment of Alzheimer's disease].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2004;66(1):29-58; discussion 58-9.
2003: Stefan F Lichtenthaler; Diana-Ines Dominguez; Gil G Westmeyer; Karina Reiss; Christian Haass; Paul Saftig; Bart De Strooper; Brian Seed
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
The Journal of biological chemistry 2003;278(49):48713-9.
2003: Joachim G Schulz; Willem ANNAERT; Joël Vandekerckhove; Pascale Zimmermann; Bart De Strooper; Guido David
Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling.
The Journal of biological chemistry 2003;278(49):48651-7.
2003: Omar Nyabi; Mostafa Bentahir; Katrien Horré; An Herreman; Numa Gottardi-Littell; Christine Van Broeckhoven; Pascal Merchiers; Kurt Spittaels; Willem ANNAERT; Bart De Strooper
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.
The Journal of biological chemistry 2003;278(44):43430-6.
2003: Eric H Schroeter; Ma Xenia G Ilagan; Anne L Brunkan; Silva Hecimovic; Yueming Li; Min Xu; Huw D Lewis; Meera T Saxena; Bart De Strooper; Archie Coonrod; Taisuke Tomita; Takeshi Iwatsubo; Chad L Moore; Alison Goate; Michael S Wolfe; Mark S Shearman; Raphael Kopan
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13075-80.
2003: Yves Moreau; Stein Aerts; Bart De Moor; Bart De Strooper; Michal Dabrowski
Comparison and meta-analysis of microarray data: from the bench to the computer desk.
Trends in genetics : TIG 2003;19(10):570-7.
2003: Philipp J Kahle; Bart De Strooper
Attack on amyloid.
EMBO reports 2003;4(8):747-51.
2003: Erwin Lauwers; zeger debyser; Jo Van Dorpe; Bart De Strooper; Bart Nuttin; Veerle Baekelandt
Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.
Brain pathology (Zurich, Switzerland) 2003;13(3):364-72.
2003: Michal Dabrowski; Stein Aerts; Paul van Hummelen; Katleen Craessaerts; Bart De Moor; Willem ANNAERT; Yves Moreau; Bart De Strooper
Gene profiling of hippocampal neuronal culture.
Journal of neurochemistry 2003;85(5):1279-88.
2003: Bart De Strooper; James R Woodgett
Alzheimer's disease: Mental plaque removal.
Nature 2003;423(6938):392-3.
2003: Bart De Strooper
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.
Neuron 2003;38(1):9-12.
2003: An Herreman; Geert Van Gassen; Mostafa Bentahir; Omar Nyabi; Katleen Craessaerts; Ulrike Mueller; Willem ANNAERT; Bart De Strooper
gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation.
Journal of cell science 2003;116(Pt 6):1127-36.
2003: Daizo Murakami; Isamu Okamoto; Osamu Nagano; Yoshiaki Kawano; Taisuke Tomita; Takeshi Iwatsubo; Bart De Strooper; Eiji Yumoto; Hideyuki Saya
Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.
Oncogene 2003;22(10):1511-6.
2002: Samir Kumar-Singh; Ann Julliams; Rony Nuydens; Chantal Ceuterick; Christine Labeur; Sally Serneels; Krist'l Vennekens; Peter Van Osta; Hugo Geerts; Bart De Strooper; Christine Van Broeckhoven
In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity.
Neurobiology of disease 2002;11(2):330-40.
2002: Dieter Hartmann; Bart De Strooper; Lutgarde Serneels; Katleen Craessaerts; An Herreman; Willem ANNAERT; Lieve Umans; Torben Lübke; Anna Lena Illert; Kurt von Figura; Paul Saftig
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Human molecular genetics 2002;11(21):2615-24.
2002: David E Kang; Salvador Soriano; Xuefeng Xia; Charles G Eberhart; Bart De Strooper; Hui Zheng; Edward H Koo
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis.
Cell 2002;110(6):751-62.
2002: Diana-Ines Dominguez; Bart De Strooper
Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease.
Trends in pharmacological sciences 2002;23(7):324-30.
2002: Omar Nyabi; Stefan Pype; Marc Mercken; An Herreman; Paul Saftig; Katleen Craessaerts; Lutgarde Serneels; Willem ANNAERT; Bart De Strooper
No endogenous A beta production in presenilin-deficient fibroblasts.
Nature cell biology 2002;4(7):E164; author reply E165-6.
2002: Veerle Baekelandt; Anje Claeys; Kristel Eggermont; Erwin Lauwers; Bart De Strooper; Bart Nuttin; zeger debyser
Characterization of lentiviral vector-mediated gene transfer in adult mouse brain.
Human gene therapy 2002;13(7):841-53.
2002: Dorothy G Flood; Andrew G Reaume; Karen S Dorfman; Yin-Guo Lin; Diane M Lang; Stephen P Trusko; Mary J Savage; Willem ANNAERT; Bart De Strooper; Robert Siman; Richard W Scott
FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.
Neurobiology of aging 2002;23(3):335-48.
2002: Xiaorei Sai; Yuuki Kawamura; Koichi Kokame; Haruyasu Yamaguchi; Hirohisa Shiraishi; Ryo Suzuki; Toshiharu Suzuki; Masashi Kawaichi; Toshiyuki Miyata; Toshio Kitamura; Bart De Strooper; Katsuhiko Yanagisawa; Hiroto Komano
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein.
The Journal of biological chemistry 2002;277(15):12915-20.
2002: Malcolm Leissring; Michael Murphy; Tonya R Mead; Yama Akbari; Michael C Sugarman; Mehrdad Jannatipour; Brigitte Anliker; Ulrike Müller; Paul Saftig; Bart De Strooper; Michael S Wolfe; todd golde; Frank M LaFerla
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4697-702.
2002: Willem ANNAERT; Bart De Strooper
A cell biological perspective on Alzheimer's disease.
Annual review of cell and developmental biology 2002;18():25-51.
2001: Willem ANNAERT; Cary Esselens; Veerle Baert; C Boeve; G Snellings; P Cupers; Katleen Craessaerts; Bart De Strooper
Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.
Neuron 2001;32(4):579-89.
2001: Jens Wiltfang; Hermann Esselmann; P Cupers; M Neumann; Hans A Kretzschmar; M Beyermann; D Schleuder; Holger Jahn; E Rüther; J Kornhuber; Willem ANNAERT; Bart De Strooper; Paul Saftig
Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.
The Journal of biological chemistry 2001;276(46):42645-57.
2001: Bart De Strooper; G König
An inflammatory drug prospect.
Nature 2001;414(6860):159-60.
2001: Sangram S Sisodia; Willem ANNAERT; Seong-Hun Kim; Bart De Strooper
Gamma-secretase: never more enigmatic.
Trends in neurosciences 2001;24(11 Suppl):S2-6.
2001: Bruno Vincent; Erwan Paitel; P Saftig; Y Frobert; D Hartmann; Bart De Strooper; Jacques Grassi; E Lopez-Perez; Frédéric Checler
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
The Journal of biological chemistry 2001;276(41):37743-6.
2001: Dieter Hartmann; Jos Tournoy; Paul Saftig; Willem ANNAERT; Bart De Strooper
Implication of APP secretases in notch signaling.
Journal of molecular neuroscience : MN 2001;17(2):171-81.
2001: P Cupers; IC Orlans; Katleen Craessaerts; Willem ANNAERT; Bart De Strooper
The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture.
Journal of neurochemistry 2001;78(5):1168-78.
2001: Taisuke Tomita; T Watabiki; Rie Takikawa; Yuichi Morohashi; Nobumasa Takasugi; R Kopan; Bart De Strooper; Takeshi Iwatsubo
The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins.
The Journal of biological chemistry 2001;276(35):33273-81.
2001: P Cupers; Mostafa Bentahir; Katleen Craessaerts; IC Orlans; hugo vanderstichele; Paul Saftig; Bart De Strooper; Willem ANNAERT
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
The Journal of cell biology 2001;154(4):731-40.
2001: Chris De Jonghe; Cary Esselens; Samir Kumar-Singh; Katleen Craessaerts; Sally Serneels; F Checler; Willem ANNAERT; Christine Van Broeckhoven; Bart De Strooper
Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.
Human molecular genetics 2001;10(16):1665-71.
2001: Diana-Ines Dominguez; Bart De Strooper; Willem ANNAERT
Secretases as therapeutic targets for the treatment of Alzheimer's disease.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8(2):124-42.
2001: Bart De Strooper; Willem ANNAERT
Where Notch and Wnt signaling meet. The presenilin hub.
The Journal of cell biology 2001;152(4):F17-20.
2001: John W M Creemers; D Ines Dominguez; E Plets; Lutgarde Serneels; Neil A Taylor; Gerd Multhaup; Katleen Craessaerts; Willem ANNAERT; Bart De Strooper
Processing of beta-secretase by furin and other members of the proprotein convertase family.
The Journal of biological chemistry 2001;276(6):4211-7.
2000: Maria Dolores Ledesma; Jorge Santos da Silva; K Crassaerts; André Delacourte; Bart De Strooper; Carlos G Dotti
Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains.
EMBO reports 2000;1(6):530-5.
2000: Veerle Baekelandt; Anje Claeys; Peter Cherepanov; Erik De Clercq; Bart De Strooper; Bart Nuttin; zeger debyser
DNA-Dependent protein kinase is not required for efficient lentivirus integration.
Journal of virology 2000;74(23):11278-85.
2000: Samir Kumar-Singh; Chris De Jonghe; Marc Cruts; R Kleinert; Rong Wang; Marc Mercken; Bart De Strooper; hugo vanderstichele; Ann Löfgren; I Vanderhoeven; Hubert Backhovens; Eugeen Vanmechelen; P M Kroisel; Christine Van Broeckhoven
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
Human molecular genetics 2000;9(18):2589-98.
2000: Veerle Baekelandt; Bart De Strooper; Bart Nuttin; zeger debyser
Gene therapeutic strategies for neurodegenerative diseases.
Current opinion in molecular therapeutics 2000;2(5):540-54.
2000: Willem ANNAERT; Bart De Strooper
Neuronal models to study amyloid precursor protein expression and processing in vitro.
Biochimica et biophysica acta 2000;1502(1):53-62.
2000: An Herreman; Lutgarde Serneels; Willem ANNAERT; D Collen; L Schoonjans; Bart De Strooper
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.
Nature cell biology 2000;2(7):461-2.
2000: Bart De Strooper
Alzheimer's disease. Closing in on gamma-secretase.
Nature 2000;405(6787):627, 629.
2000: Bart De Strooper; Willem ANNAERT
Proteolytic processing and cell biological functions of the amyloid precursor protein.
Journal of cell science 2000;113 ( Pt 11)():1857-70.
2000: Willem ANNAERT; P Cupers; Paul Saftig; Bart De Strooper
Presenilin function in APP processing.
Annals of the New York Academy of Sciences 2000;920():158-64.
1999: Bart De Strooper; G König
Alzheimer's disease. A firm base for drug development.
Nature 1999;402(6761):471-2.
1999: Christian Haass; Bart De Strooper
The presenilins in Alzheimer's disease--proteolysis holds the key.
Science (New York, N.Y.) 1999;286(5441):916-9.
1999: Willem ANNAERT; L Levesque; Katleen Craessaerts; I Dierinck; G Snellings; David Westaway; Peter St George-Hyslop; Barbara Cordell; Paul E Fraser; Bart De Strooper
Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons.
The Journal of cell biology 1999;147(2):277-94.
1999: An Herreman; Dieter Hartmann; Willem ANNAERT; Paul Saftig; Katleen Craessaerts; Lutgarde Serneels; Lieve Umans; V Schrijvers; F Checler; hugo vanderstichele; Veerle Baekelandt; R Dressel; P Cupers; Danny Huylebroeck; An Zwijsen; Fred Van Leuven; Bart De Strooper
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11872-7.
1999: Willem ANNAERT; Bart De Strooper
Presenilins: molecular switches between proteolysis and signal transduction.
Trends in neurosciences 1999;22(10):439-43.
1999: L Lévesque; Willem ANNAERT; Katleen Craessaerts; Paul Mathews; M Seeger; Ralph A. Nixon; Fred Van Leuven; Sam Gandy; David Westaway; Peter St George-Hyslop; Bart De Strooper; Paul E Fraser
Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.
Molecular medicine (Cambridge, Mass.) 1999;5(8):542-54.
1999: Dieter Hartmann; Bart De Strooper; Paul Saftig
Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly.
Current biology : CB 1999;9(14):719-27.
1999: Bart De Strooper; Willem ANNAERT; P Cupers; Paul Saftig; Katleen Craessaerts; Jeff S. Mumm; Eric H Schroeter; V Schrijvers; Michael S Wolfe; William Ray; Alison Goate; Raphael Kopan
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Nature 1999;398(6727):518-22.
1999: Paul Saftig; Dieter Hartmann; Bart De Strooper
The function of presenilin-1 in amyloid beta-peptide generation and brain development.
European archives of psychiatry and clinical neuroscience 1999;249(6):271-9.
1998: Zhuohua Zhang; H Hartmann; V M Do; Dorothee Abramowski; Christine Sturchler-Pierrat; Matthias Staufenbiel; Bernd Sommer; M van de Wetering; H Clevers; P Saftig; Bart De Strooper; X He; Bruce A Yankner
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
Nature 1998;395(6703):698-702.
1998: Dieder Moechars; K Lorent; Ilse Dewachter; Veerle Baekelandt; Bart De Strooper; Fred Van Leuven
Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder.
Behavioural brain research 1998;95(1):55-64.
1998: Paul Saftig; Bart De Strooper
Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes.
Molecular psychiatry 1998;3(4):287-9.
1998: M Simons; P Keller; Bart De Strooper; Konrad Beyreuther; Carlos G Dotti; Kai Simons
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6460-4.
1998: Bart De Strooper; Paul Saftig; Katleen Craessaerts; hugo vanderstichele; G Guhde; Willem ANNAERT; Kurt von Figura; Fred Van Leuven
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
Nature 1998;391(6665):387-90.
1997: Bart De Strooper; M Beullens; B Contreras; L Levesque; Katleen Craessaerts; Barbara Cordell; Dieder Moechars; M Bollen; Paul E Fraser; Peter St George-Hyslop; Fred Van Leuven
Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.
The Journal of biological chemistry 1997;272(6):3590-8.
1996: Paul Saftig; Christoph Peters; Kurt von Figura; Katleen Craessaerts; Fred Van Leuven; Bart De Strooper
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.
The Journal of biological chemistry 1996;271(44):27241-4.
1996: P J Tienari; Bart De Strooper; E Ikonen; M Simons; Andreas Weidemann; C Czech; Tobias Hartmann; N Ida; Gerd Multhaup; Colin L Masters; Fred Van Leuven; Konrad Beyreuther; Carlos G Dotti
The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein.
The EMBO journal 1996;15(19):5218-29.
1996: Dieder Moechars; K Lorent; Bart De Strooper; Ilse Dewachter; Fred Van Leuven
Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.
The EMBO journal 1996;15(6):1265-74.
1996: M Simons; Bart De Strooper; Gerd Multhaup; P J Tienari; Carlos G Dotti; Konrad Beyreuther
Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(3):899-908.
1996: P J Tienari; Bart De Strooper; E Ikonen; N Ida; M Simons; Colin L Masters; Carlos G Dotti; Konrad Beyreuther
Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease.
Cold Spring Harbor symposia on quantitative biology 1996;61():575-85.
1996: Bart De Strooper; R R Wu; Martine Jaspers; B Van der Schueren; S Vekemans; Geert Carmeliet; Fred Van Leuven; Joost J van den Oord; Jean-Jacques Cassiman
A 68-kD antigen, which is probably an N-terminal fragment of the VLA-5 alpha 5-subunit, is specific for differentiating keratinocytes.
Dermatology (Basel, Switzerland) 1996;193(3):212-20.
1995: Bart De Strooper; Katleen Craessaerts; Fred Van Leuven; Herman Van Den Berghe
Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells.
The Journal of biological chemistry 1995;270(51):30310-4.
1995: Bart De Strooper; M Simons; Gerd Multhaup; Fred Van Leuven; Konrad Beyreuther; Carlos G Dotti
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
The EMBO journal 1995;14(20):4932-8.
1995: K Lorent; Lut Overbergh; Dieder Moechars; Bart De Strooper; Fred Van Leuven; Herman Van Den Berghe
Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein.
Neuroscience 1995;65(4):1009-25.
1995: D Van Gool; Bart De Strooper; Fred Van Leuven; René Dom
Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease.
Dementia (Basel, Switzerland) 1995;6(2):63-8.
1995: Bart De Strooper; Katleen Craessaerts; Ilse Dewachter; Dieder Moechars; Barry D Greenberg; Fred Van Leuven; Herman Van Den Berghe
Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease.
The Journal of biological chemistry 1995;270(8):4058-65.
1995: Fred Van Leuven; C Hilliker; Lutgarde Serneels; Lieve Umans; Lut Overbergh; Bart De Strooper; J P Fryns; Herman Van Den Berghe
Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein.
Genomics 1995;25(2):492-500.
1995: Bart De Strooper; John W M Creemers; Dieder Moechars; Danny Huylebroeck; Wim J M Van De Ven; Fred Van Leuven; Herman Van Den Berghe
Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes.
Biochimica et biophysica acta 1995;1246(2):185-8.
1994: Fred Van Leuven; L Stas; C Hilliker; K Lorent; Lieve Umans; Lutgarde Serneels; Lut Overbergh; S Torrekens; Dieder Moechars; Bart De Strooper
Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein.
Genomics 1994;24(1):78-89.
1994: Lieve Umans; Lutgarde Serneels; C Hilliker; L Stas; Lut Overbergh; Bart De Strooper; Fred Van Leuven; Herman Van Den Berghe
Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells.
Genomics 1994;22(3):519-29.
1993: Martine Jaspers; S Vekemans; Geert Carmeliet; Fred Van Leuven; Bart De Strooper; H Deckmyn; Jean-Jacques Cassiman
A monoclonal antibody to the alpha 2 integrin subunit cross-reacts with RGD-dependent epitopes in fibrinogen.
Hybridoma 1993;12(4):467-74.
1993: D Van Gool; Bart De Strooper; Fred Van Leuven; E Triau; René Dom
alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease.
Neurobiology of aging 1993;14(3):233-7.
1993: Fred Van Leuven; L Stas; L Raymakers; Lut Overbergh; Bart De Strooper; C Hilliker; K Lorent; E Fias; Lieve Umans; S Torrekens
Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA.
Biochimica et biophysica acta 1993;1173(1):71-4.
1993: Bart De Strooper; Lieve Umans; Fred Van Leuven; Herman Van Den Berghe
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
The Journal of cell biology 1993;121(2):295-304.
1993: Bart De Strooper; Fred Van Leuven
Alpha 2-macroglobulin and subacute-phase responses in Alzheimer's disease.
Immunology today 1993;14(3):143-4.
1992: Jan Delabie; R Shipman; J Brüggen; Bart De Strooper; Fred Van Leuven; L Tarcsay; N Cerletti; K Odink; V Diehl; Graeme Bilbe
Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma.
Blood 1992;80(11):2891-6.
1992: Fred Van Leuven; S Torrekens; Lut Overbergh; K Lorent; Bart De Strooper; Herman Van Den Berghe
The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA.
European journal of biochemistry / FEBS 1992;210(1):319-27.
1992: Bart De Strooper; Fred Van Leuven; Herman Van Den Berghe
Alpha 2-macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells.
FEBS letters 1992;308(1):50-3.
1992: Bart De Strooper
[University education is more than higher education].
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1992;54(6):631-6.
1991: Bart De Strooper; Fred Van Leuven; Herman Van Den Berghe
The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported.
Biochimica et biophysica acta 1991;1129(1):141-3.
1991: Bart De Strooper; Fred Van Leuven; Geert Carmeliet; Herman Van Den Berghe; Jean-Jacques Cassiman
Cultured human fibroblasts contain a large pool of precursor beta 1-integrin but lack an intracellular pool of mature subunit.
European journal of biochemistry / FEBS 1991;199(1):25-33.
1989: Bart De Strooper; B Van der Schueren; Martine Jaspers; M Saison; M Spaepen; Fred Van Leuven; Herman Van Den Berghe; Jean-Jacques Cassiman
Distribution of the beta 1 subgroup of the integrins in human cells and tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1989;37(3):299-307.
1988: Martine Jaspers; Bart De Strooper; M Spaepen; Fred Van Leuven; G David; Herman Van Den Berghe; Jean-Jacques Cassiman
Post-translational modification of the beta-subunit of the human fibronectin receptor.
FEBS letters 1988;231(2):402-6.
1988: Bart De Strooper; M Saison; Martine Jaspers; M Spaepen; Fred Van Leuven; Herman Van Den Berghe; Jean-Jacques Cassiman
Monoclonal antibody DH12 reacts with a cell surface and a precursor form of the beta subunit of the human fibronectin receptor.
Cell biology international reports 1988;12(1):9-16.
1988: Y Zhang; M Saison; M Spaepen; Bart De Strooper; Fred Van Leuven; G David; Herman Van Den Berghe; Jean-Jacques Cassiman
Mapping of human fibronectin receptor beta subunit gene to chromosome 10.
Somatic cell and molecular genetics 1988;14(1):99-104.