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Rashid Deane

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TOP 3
Abhay Sagare; Rashid Deane; Berislav V Zlokovic
Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities.
Joseph M Castellano; Rashid Deane; Ronald B DeMattos; Andrew J Gottesdiener; Tristan R Kasper; Andrew C Paoletti; Floy R Stewart; Philip B Verghese; Tim West; Berislav V Zlokovic; David M Holtzman
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.
Jeffrey J Iliff; Yonghong Liao; Erlend A Nagelhus; Helene Benveniste; Rashid Deane; Steven A Goldman; Georg A Gundersen; Weiguo Peng; Benjamin A Plogg; G Edward Vates; Minghuan Wang; Maiken Nedergaard
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

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All Publications

2012: Abhay Sagare; Rashid Deane; Berislav V Zlokovic
Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities.
Pharmacology & therapeutics 2012;136(1):94-105.
2012: Joseph M Castellano; Rashid Deane; Ronald B DeMattos; Andrew J Gottesdiener; Tristan R Kasper; Andrew C Paoletti; Floy R Stewart; Philip B Verghese; Tim West; Berislav V Zlokovic; David M Holtzman
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15502-7.
2012: Jeffrey J Iliff; Yonghong Liao; Erlend A Nagelhus; Helene Benveniste; Rashid Deane; Steven A Goldman; Georg A Gundersen; Weiguo Peng; Benjamin A Plogg; G Edward Vates; Minghuan Wang; Maiken Nedergaard
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Science translational medicine 2012;4(147):147ra111.
2012: Robert D Bell; Bradford C Berk; Christer Betsholtz; Rashid Deane; David M Holtzman; Abhay Sagare; Jan Sallstrom; Itender Singh; Ethan A Winkler; Zhenhua Wu; Annika Armulik; Berislav V Zlokovic
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.
Nature 2012;485(7399):512-6.
2012: Rashid Deane; Richard J Deane; Alan E Friedman; Gunter Fritz; Barbra LaRue; Rachal Love; Benjamin L Miller; Nicole Paquette; Sheldon Perry; Nathan T Ross; Abhay P Sagare; Itender Singh; Meenakshisundaram Thiyagarajan; Troy Zarcone; Robert D Bell; Berislav V Zlokovic
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.
The Journal of clinical investigation 2012;122(4):1377-92.
2011: Abhay P Sagare; Ethan A Winkler; Robert D Bell; Rashid Deane; Berislav V Zlokovic
From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels.
Journal of neuroscience research 2011;89(7):967-8.
2011: Oksana Polesskaya; Jharon Silva; Christine Sanfilippo; Taylor Desrosiers; Anita Sun; Jie Shen; Changyong Feng; Aleksey Polesskiy; Rashid Deane; Berislav V Zlokovic; Karl Kasischke; Stephen Dewhurst
Methamphetamine causes sustained depression in cerebral blood flow.
Brain research 2011;1373():91-100.
2011: Abhay Sagare; Rashid Deane; Henrik Zetterberg; Anders Wallin; Kaj Blennow; Berislav V Zlokovic
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2011;24(1):25-34.
2010: Berislav V Zlokovic; Rashid Deane; Abhay Sagare; Robert D Bell; Ethan A Winkler
Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain.
Journal of neurochemistry 2010;115(5):1077-89.
2010: Robert D Bell; Ethan A Winkler; Abhay Sagare; Itender Singh; Barbra LaRue; Rashid Deane; Berislav V Zlokovic
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.
Neuron 2010;68(3):409-27.
2010: Donghui Zhu; Yaoming Wang; Itender Singh; Robert D Bell; Rashid Deane; Zhihui Zhong; Abhay Sagare; Ethan A Winkler; Berislav V Zlokovic
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.
Blood 2010;115(23):4963-72.
2010: Prashanthi Menon; Rashid Deane; Abhay Sagare; Steven M Lane; Troy J Zarcone; Michael R O'Dell; Chen Yan; Berislav V Zlokovic; Bradford C Berk
Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.
Brain research 2010;1317():218-26.
2009: Zhihui Zhong; Hristelina Ilieva; Lee Hallagan; Robert Bell; Itender Singh; Nicole Paquette; Meenakshisundaram Thiyagarajan; Rashid Deane; Jose A Fernandez; Steven Lane; Anna B Zlokovic; Todd Liu; John H Griffin; Nienwen Chow; Francis J Castellino; Konstantin Stojanovic; Don W Cleveland; Berislav V Zlokovic
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.
The Journal of clinical investigation 2009;119(11):3437-49.
2009: Huang Guo; Itender Singh; Yaoming Wang; Rashid Deane; Theresa Barrett; José A Fernández; Nienwen Chow; John H Griffin; Berislav V Zlokovic
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.
The European journal of neuroscience 2009;29(6):1119-30.
2009: Rashid Deane; Robert D Bell; Abhay Sagare; Berislav V Zlokovic
Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.
CNS & neurological disorders drug targets 2009;8(1):16-30.
2009: Robert D Bell; Rashid Deane; Nienwen Chow; Xiaochun Long; Abhay Sagare; Itender Singh; Jeffrey W Streb; Huang Guo; Anna Rubio; William E Van Nostrand; Joseph M Miano; Berislav V Zlokovic
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.
Nature cell biology 2009;11(2):143-53.
2009: Rashid Deane; Barbra LaRue; Abhay P Sagare; Francis J Castellino; Zhihui Zhong; Berislav V Zlokovic
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(1):25-33.
2008: Rashid Deane; Abhay Sagare; Katie Hamm; Margaret Parisi; Steven Lane; Mary Beth Finn; David M Holtzman; Berislav V Zlokovic
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.
The Journal of clinical investigation 2008;118(12):4002-13.
2008: Zhihui Zhong; Rashid Deane; Zarina Ali; Margaret Parisi; Yuriy Shapovalov; M Kerry O'Banion; Konstantin Stojanovic; Abhay Sagare; Severine Boillee; Don W Cleveland; Berislav V Zlokovic
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.
Nature neuroscience 2008;11(4):420-2.
2008: Rashid Deane; Abhay Sagare; Berislav V Zlokovic
The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease.
Current pharmaceutical design 2008;14(16):1601-5.
2007: Nouhad A Kassem; Rashid Deane; Malcolm B Segal; RuoLi Chen; Jane E Preston
Thyroxine (T4) transfer from CSF to choroid plexus and ventricular brain regions in rabbit: contributory role of P-glycoprotein and organic anion transporting polypeptides.
Brain research 2007;1181():44-50.
2007: Abhay Sagare; Rashid Deane; Robert D Bell; Bradley Johnson; Katie Hamm; Ronan Pendu; Andrew Marky; Peter J Lenting; Zhenhua Wu; Troy Zarcone; Alison Goate; Kevin Mayo; David Perlmutter; Mireia Coma; Zhihui Zhong; Berislav V Zlokovic
Clearance of amyloid-beta by circulating lipoprotein receptors.
Nature medicine 2007;13(9):1029-31.
2007: Robert D Bell; Abhay P Sagare; Alan E Friedman; Gurrinder S Bedi; David M Holtzman; Rashid Deane; Berislav V Zlokovic
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(5):909-18.
2007: Rashid Deane; Berislav V Zlokovic
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease.
Current Alzheimer research 2007;4(2):191-7.
2007: Takahiro Takano; Xiaoning Han; Rashid Deane; Berislav V Zlokovic; Maiken Nedergaard
Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease.
Annals of the New York Academy of Sciences 2007;1097():40-50.
2007: Nienwen Chow; Robert D Bell; Rashid Deane; Jeffrey W Streb; Jiyuan Chen; Andrew Brooks; William E Van Nostrand; Joseph M Miano; Berislav V Zlokovic
Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):823-8.
2006: Tong Cheng; Anthony L Petraglia; Zhang Li; Meenakshisundaram Thiyagarajan; Zhihui Zhong; Zhenhua Wu; Dong Liu; Sanjay B Maggirwar; Rashid Deane; José A Fernández; Barbra LaRue; John H Griffin; Michael Chopp; Berislav V Zlokovic
Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.
Nature medicine 2006;12(11):1278-85.
2006: Nouhad A Kassem; Rashid Deane; Malcolm B Segal; Jane E Preston
Role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(5):R1310-5.
2005: Rashid Deane; Abhay Sagare; Katie Hamm; Margaret Parisi; Barbra LaRue; Huang Guo; Zhenhua Wu; David M Holtzman; Berislav V Zlokovic
IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(50):11495-503.
2005: John R Cirrito; Rashid Deane; Anne M Fagan; Michael L Spinner; Maia Parsadanian; Mary Beth Finn; Hong Jiang; Julie L Prior; Abhay Sagare; Kelly R Bales; Steven M Paul; Berislav V Zlokovic; David Piwnica-Worms; David M Holtzman
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.
The Journal of clinical investigation 2005;115(11):3285-90.
2005: Zhenhua Wu; Huang Guo; Nienwen Chow; Jan Sallstrom; Robert D Bell; Rashid Deane; Andrew I Brooks; Suhasini Kanagala; Anna Rubio; Abhay Sagare; Dong Liu; Fang Li; Don Armstrong; Thomas Gasiewicz; Raphael Zidovetzki; Xiaomei Song; Florence M Hofman; Berislav V Zlokovic
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease.
Nature medicine 2005;11(9):959-65.
2005: Berislav V Zlokovic; Rashid Deane; Jan Sallstrom; Nienwen Chow; Joseph M Miano
Neurovascular pathways and Alzheimer amyloid beta-peptide.
Brain pathology (Zurich, Switzerland) 2005;15(1):78-83.
2004: Rashid Deane; Zhenhua Wu; Berislav V Zlokovic
RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier.
Stroke; a journal of cerebral circulation 2004;35(11 Suppl 1):2628-31.
2004: Barbra LaRue; Elizabeth Hogg; Abhay Sagare; Suzana Jovanovic; Lawrence Maness; Calvin Maurer; Rashid Deane; Berislav V Zlokovic
Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice.
Journal of neuroscience methods 2004;138(1-2):233-42.
2004: Rashid Deane; Zhenhua Wu; Abhay Sagare; Judianne Davis; Shi Du Yan; Katie Hamm; Feng Xu; Margaret Parisi; Barbra LaRue; Hong Wei Hu; Patricia Spijkers; Huang Guo; Xiaomei Song; Peter J Lenting; William E Van Nostrand; Berislav V Zlokovic
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.
Neuron 2004;43(3):333-44.
2004: Judianne Davis; Feng Xu; Rashid Deane; Galina Romanov; Mary Lou Previti; Kelly Zeigler; Berislav V Zlokovic; William E Van Nostrand
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor.
The Journal of biological chemistry 2004;279(19):20296-306.
2004: Rashid Deane; Wei Zheng; Berislav V Zlokovic
Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain.
Journal of neurochemistry 2004;88(4):813-20.
2003: Rashid Deane; Shi Du Yan; Ram Kumar Submamaryan; Barbra LaRue; Suzana Jovanovic; Elizabeth Hogg; Deborah Welch; Lawrence Manness; Chang Lin; Jin Yu; Hong Zhu; Jorge Ghiso; Blas Frangione; Alan Stern; Ann Marie Schmidt; Don L Armstrong; Bernd Arnold; Birgit Liliensiek; Peter Nawroth; Florence M Hofman; Mark S Kindy; David M Stern; Berislav V Zlokovic
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Nature medicine 2003;9(7):907-13.
2003: Wei Zheng; Rashid Deane; Zoran B Redzic; Jane E Preston; Malcolm B Segal
Transport of L-[125I]thyroxine by in situ perfused ovine choroid plexus: inhibition by lead exposure.
Journal of toxicology and environmental health. Part A 2003;66(5):435-51.
1993: M W Bradbury; Rashid Deane
Permeability of the blood-brain barrier to lead.
Neurotoxicology 1993;14(2-3):131-6.
1990: Rashid Deane; M W Bradbury
Transport of lead-203 at the blood-brain barrier during short cerebrovascular perfusion with saline in the rat.
Journal of neurochemistry 1990;54(3):905-14.
1988: M W Bradbury; Rashid Deane
Brain endothelium and interstitium as sites for effects of lead.
Annals of the New York Academy of Sciences 1988;529():1-8.
1987: Hazel C Jones; Rashid Deane; R M Bucknall
Developmental changes in cerebrospinal fluid pressure and resistance to absorption in rats.
Brain research 1987;430(1):23-30.
1986: Rashid Deane; S H Park; M W Bradbury
Effect of intravenous ferric or aluminum chloride on the uptake of 203Pb into brain and other soft tissues of rats.
The Journal of pharmacology and experimental therapeutics 1986;239(2):548-53.
1986: M W Bradbury; Rashid Deane
Rate of uptake of lead-203 into brain and other soft tissues of the rat at constant radiotracer levels in plasma.
Annals of the New York Academy of Sciences 1986;481():142-60.
1985: Rashid Deane; M B Segal
The transport of sugars across the perfused choroid plexus of the sheep.
The Journal of physiology 1985;362():245-60.
1979: Rashid Deane; M B Segal
The effect of vascular perfusion of the choroid plexus on the secretion of cerebrospinal fluid [proceedings].
The Journal of physiology 1979;293():18P-19P.
1979: Rashid Deane; M B Segal
The effect of phloridzin, phloretin and theophylline on the transport of sugars by the choroid plexus [proceedings].
The Journal of physiology 1979;287():35P-36P.
1978: Rashid Deane; M B Segal
Effect of vascular perfusion on the transfer of sugars across the choroid plexus of the sheep [proceedings].
The Journal of physiology 1978;285():57P.
1976: Rashid Deane; M B Segal
The sodium-dependent absorption of sugars across the coroid plexus of the sheep [proceedings].
The Journal of physiology 1976;263(2):274P-275P.