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Wendell Weber

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All Publications

2010: Wendell W Weber
The promise of epigenetics in personalized medicine.
Molecular interventions 2010;10(6):363-70.
2008: Wendell W Weber
Pharmacogenetics: from description to prediction.
Clinics in laboratory medicine 2008;28(4):499-511.
2001: Wendell W Weber
The legacy of pharmacogenetics and potential applications.
Mutation research 2001;479(1-2):1-18.
2001: Wendell W Weber
Pharmacogenetic tactics and strategies: implications for paediatrics.
Paediatric drugs 2001;3(12):863-81.
2001: Wendell W Weber
Effect of pharmacogenetics on medicine.
Environmental and molecular mutagenesis 2001;37(3):179-84.
2000: David W Hein; Charlene A McQueen; Denis M Grant; Geoffrey H Goodfellow; Fred F Kadlubar; Wendell W Weber
Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1425-32.
2000: J H de León; Kostas P Vatsis; Wendell W Weber
Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1.
Molecular pharmacology 2000;58(2):288-99.
2000: Lourdes Estrada; Kimon C Kanelakis; GN Levy; Wendell W Weber
Tissue- and gender-specific expression of N-acetyltransferase 2 (Nat2*) during development of the outbred mouse strain CD-1.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(2):139-46.
1999: Wendell W Weber
Populations and genetic polymorphisms.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology 1999;4(4):299-307.
1998: L Estrada-Rodgers; GN Levy; Wendell W Weber
Substrate selectivity of mouse N-acetyltransferases 1, 2, and 3 expressed in COS-1 cells.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(5):502-5.
1998: L Estrada-Rodgers; GN Levy; Wendell W Weber
Characterization of a hormone response element in the mouse N-acetyltransferase 2 (Nat2*) promoter.
Gene expression 1998;7(1):13-24.
1997: Y Liu; GN Levy; Wendell W Weber
Induction of human prostaglandin endoperoxide H synthase-2 (PHS-2) mRNA by TCDD.
Prostaglandins 1997;53(1):1-10.
1997: Jau-Hong Lee; Jing-Gung Chung; J M Lai; GN Levy; Wendell W Weber
Kinetics of arylamine N-acetyltransferase in tissues from human breast cancer.
Cancer letters 1997;111(1-2):39-50.
1996: GN Levy; L Rodgers; Wendell W Weber
Effects of heredity on response to drugs and environmental chemicals: construction of rodent models.
Chemical research in toxicology 1996;9(8):1215-24.
1996: Jing-Gung Chung; H M Kuo; T H Lin; Chin-Chin Ho; Jau-Hong Lee; J M Lai; GN Levy; Wendell W Weber
Evidence for arylamine N-acetyltransferase in the nematode Anisakis simplex.
Cancer letters 1996;106(1):1-8.
1996: P V Nerurkar; H A Schut; Lucy M Anderson; C W Riggs; L W Fornwald; C D Davis; E G Snyderwine; S S Thorgeirsson; Wendell W Weber; Jerry M Rice; GN Levy
Ahr locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline in the absence of cytochrome P450 induction.
Molecular pharmacology 1996;49(5):874-81.
1996: Chin-Chin Ho; T H Lin; Yih-Shyong Lai; Jing-Gung Chung; GN Levy; Wendell W Weber
Kinetics of acetyl coenzyme A:arylamine N-acetyltransferase from rapid and slow acetylator frog tissues.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(2):137-41.
1995: J H De Leon; K J Martell; K P Vatsis; Wendell W Weber
Slow acetylation in mice is caused by a labile and catalytically impaired mutant N-acetyltransferase (NAT2 9).
Drug metabolism and disposition: the biological fate of chemicals 1995;23(12):1354-61.
1995: Y Liu; GN Levy; Wendell W Weber
Activation of 2-aminofluorene by prostaglandin endoperoxide H synthase-2.
Biochemical and biophysical research communications 1995;215(1):346-54.
1995: P V Nerurkar; H A Schut; Lucy M Anderson; C W Riggs; E G Snyderwine; S S Thorgeirsson; Wendell W Weber; Jerry M Rice; GN Levy
DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype.
Cancer research 1995;55(14):3043-9.
1995: K P Vatsis; Wendell W Weber; D A Bell; Jean-Marie Dupret; D A Evans; Denis M Grant; D W Hein; H J Lin; U A Meyer; Mary Relling
Nomenclature for N-acetyltransferases.
Pharmacogenetics 1995;5(1):1-17.
1995: Wendell W Weber
Influence of heredity on human sensitivity to environmental chemicals.
Environmental and molecular mutagenesis 1995;25 Suppl 26():102-14.
1994: GN Levy; Jing-Gung Chung; Wendell W Weber
2-Aminofluorene metabolism and DNA adduct formation by mononuclear leukocytes from rapid and slow acetylator mouse strains.
Carcinogenesis 1994;15(2):353-7.
1993: Jing-Gung Chung; GN Levy; Wendell W Weber
Distribution of 2-aminofluorene and p-aminobenzoic acid N-acetyltransferase activity in tissues of C57BL/6J rapid and B6.A-NatS slow acetylator congenic mice.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1057-63.
1993: K J Martell; Wendell W Weber
N-acetylation polymorphism in liver and pancreas of inbred rats.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(5):965-6.
1993: Wendell W Weber; K P Vatsis
Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral blood.
Pharmacogenetics 1993;3(4):209-12.
1993: GN Levy; K J Martell; Wendell W Weber
Polymorphic N-acetylation of 2-aminofluorene by cell-free colon extracts from inbred mice.
Pharmacogenetics 1993;3(2):71-6.
1993: K P Vatsis; Wendell W Weber
Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus.
Archives of biochemistry and biophysics 1993;301(1):71-6.
1993: T N Smolen; J A Brewer; Wendell W Weber
Testosterone modulation of N-acetylation in mouse kidney.
The Journal of pharmacology and experimental therapeutics 1993;264(2):854-8.
1993: R A Voice; M Manis; Wendell W Weber
Inhibition of human red blood cell N-acetyltransferase.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(1):181-3.
1992: T J Flammang; Letha H Couch; GN Levy; Wendell W Weber; C K Wise
DNA adduct levels in congenic rapid and slow acetylator mouse strains following chronic administration of 4-aminobiphenyl.
Carcinogenesis 1992;13(10):1887-91.
1992: GN Levy; K J Martell; J H DeLeon; Wendell W Weber
Metabolic, molecular genetic and toxicological aspects of the acetylation polymorphism in inbred mice.
Pharmacogenetics 1992;2(5):197-206.
1992: K J Martell; GN Levy; Wendell W Weber
Cloned mouse N-acetyltransferases: enzymatic properties of expressed Nat-1 and Nat-2 gene products.
Molecular pharmacology 1992;42(2):265-72.
1992: GN Levy; Wendell W Weber
2-Aminofluorene-DNA adducts in mouse urinary bladder: effect of age, sex and acetylator phenotype.
Carcinogenesis 1992;13(2):159-64.
1991: D R Juberg; J T Bond; Wendell W Weber
N-acetylation of aromatic amines: genetic polymorphism in inbred rat strains.
Pharmacogenetics 1991;1(1):50-7.
1991: K J Martell; K P Vatsis; Wendell W Weber
Molecular genetic basis of rapid and slow acetylation in mice.
Molecular pharmacology 1991;40(2):218-27.
1991: K P Vatsis; K J Martell; Wendell W Weber
Diverse point mutations in the human gene for polymorphic N-acetyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6333-7.
1991: A J Kilbane; T Petroff; Wendell W Weber
Kinetics of acetyl CoA: arylamine N-acetyltransferase from rapid and slow acetylator human liver.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(2):503-7.
1991: Elzbieta Holsztynska; Wendell W Weber; Edward Domino
Genetic polymorphism of cytochrome P-450-dependent phencyclidine hydroxylation in mice. Comparison of phencyclidine hydroxylation in humans.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):48-53.
1990: GN Levy; Wendell W Weber
2-aminofluorene-hepatic DNA adducts in congenic mouse lines differing in Ah responsiveness.
Carcinogenesis 1990;11(7):1233-5.
1990: A J Kilbane; Lawrence K Silbart; M Manis; I Z Beitins; Wendell W Weber
Human N-acetylation genotype determination with urinary caffeine metabolites.
Clinical pharmacology and therapeutics 1990;47(4):470-7.
1990: Wendell W Weber
Acetylation.
Birth defects original article series 1990;26(1):43-65.
1990: Wendell W Weber; GN Levy; K J Martell
Polymorphic acetylation of arylamines and DNA-adduct formation.
Princess Takamatsu symposia 1990;21():119-26.
1989: S S Mattano; Susan J Land; C M King; Wendell W Weber
Purification and biochemical characterization of hepatic arylamine N-acetyltransferase from rapid and slow acetylator mice: identity with arylhydroxamic acid N,O-acyltransferase and N-hydroxyarylamine O-acetyltransferase.
Molecular pharmacology 1989;35(5):599-609.
1989: GN Levy; Wendell W Weber
2-Aminofluorene-DNA adduct formation in acetylator congenic mouse lines.
Carcinogenesis 1989;10(4):705-9.
1988: GN Levy; Wendell W Weber
High-performance liquid chromatographic analysis of 32P-postlabeled DNA-aromatic carcinogen adducts.
Analytical biochemistry 1988;174(2):381-92.
1988: S S Mattano; R P Erickson; M N Nesbitt; Wendell W Weber
Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase.
The Journal of heredity 1988;79(6):430-3.
1988: H H Andres; A J Klem; L M Schopfer; J K Harrison; Wendell W Weber
On the active site of liver acetyl-CoA. Arylamine N-acetyltransferase from rapid acetylator rabbits (III/J).
The Journal of biological chemistry 1988;263(16):7521-7.
1988: David W Hein; A Trinidad; Toks Yerokun; R J Ferguson; Ward G Kirlin; Wendell W Weber
Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy-arylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(3):341-7.
1987: T A Hultin; Wendell W Weber
Genetic variability in deacetylation of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in inbred strains of mice.
Carcinogenesis 1987;8(12):1939-41.
1987: H H Andres; R S Vogel; G E Tarr; L Johnson; Wendell W Weber
Purification, physicochemical, and kinetic properties of liver acetyl-CoA:arylamine N-acetyltransferase from rapid acetylator rabbits.
Molecular pharmacology 1987;31(4):446-56.
1987: S S Mattano; Wendell W Weber
Kinetics of arylamine N-acetyltransferase in tissues from rapid and slow acetylator mice.
Carcinogenesis 1987;8(1):133-7.
1987: H C Light; J J Hubert; P D Josephy; S S Mattano; Wendell W Weber
Benzidine activation in the Ames test: roles of hepatic N-acetyltransferase and other cytosolic and microsomal factors.
Carcinogenesis 1987;8(1):139-43.
1986: H H Andres; Wendell W Weber
N-acetylation pharmacogenetics. Michaelis-Menten constants for arylamine drugs as predictors of their N-acetylation rates in vivo.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(4):382-5.
1986: Wendell W Weber
The molecular basis of hereditary acetylation polymorphisms.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(4):377-81.
1986: T A Hultin; Wendell W Weber
Genetic differences in inhibition of 2-aminofluorene N-acetyltransferase activity between C57BL/6J and A/J mice.
Biochemical pharmacology 1986;35(7):1214-6.
1985: David W Hein; Ward G Kirlin; R J Ferguson; Wendell W Weber
Biochemical investigation of the basis for the genetic N-acetylation polymorphism in the inbred hamster.
The Journal of pharmacology and experimental therapeutics 1985;234(2):358-64.
1985: David W Hein; Ward G Kirlin; R J Ferguson; Wendell W Weber
Inheritance of liver N-acetyltransferase activity in the rapid and slow acetylator inbred hamster.
The Journal of pharmacology and experimental therapeutics 1985;233(3):584-7.
1985: H H Andres; A J Klem; S M Szabo; Wendell W Weber
New spectrophotometric and radiochemical assays for acetyl-CoA: arylamine N-acetyltransferase applicable to a variety of arylamines.
Analytical biochemistry 1985;145(2):367-75.
1985: Wendell W Weber; D W Hein
N-acetylation pharmacogenetics.
Pharmacological reviews 1985;37(1):25-79.
1985: T A Hultin; Wendell W Weber
Genetic differences in 2-aminofluorene pharmacokinetics between intact C57BL/6J and A/J mice.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(2):148-50.
1984: Wendell W Weber
Acetylation pharmacogenetics: experimental models for human toxicity.
Federation proceedings 1984;43(8):2332-7.
1984: D W Hein; Wendell W Weber
Relationship between N-acetylator phenotype and susceptibility toward hydrazine-induced lethal central nervous system toxicity in the rabbit.
The Journal of pharmacology and experimental therapeutics 1984;228(3):588-92.
1984: Wendell W Weber; T A Hultin; D A Morgott
Acetylation pharmacogenetics: profiles of arylamine pharmacology and toxicology in a genetic mouse model.
Biochemical Society transactions 1984;12(1):87-90.
1983: Wendell W Weber; D W Hein; A Litwin; G M Lower
Relationship of acetylator status to isoniazid toxicity, lupus erythematosus, and bladder cancer.
Federation proceedings 1983;42(14):3086-97.
1982: D W Hein; T N Smolen; R R Fox; Wendell W Weber
Identification of genetically homozygous rapid and slow acetylators of drugs and environmental carcinogens among established inbred rabbit strains.
The Journal of pharmacology and experimental therapeutics 1982;223(1):40-4.
1982: D W Hein; Wendell W Weber
Polymorphic N-acetylation of phenelzine and monoacetylhydrazine by highly purified rabbit liver isoniazid N-acetyltransferase.
Drug metabolism and disposition: the biological fate of chemicals 1982;10(3):225-9.
1982: I B Glowinski; Wendell W Weber
Biochemical characterization of genetically variant aromatic amine N-acetyltransferases in A/J and C57BL/6J mice.
The Journal of biological chemistry 1982;257(3):1431-7.
1982: I B Glowinski; Wendell W Weber
Genetic regulation of aromatic amine N-acetylation in inbred mice.
The Journal of biological chemistry 1982;257(3):1424-30.
1982: C A McQueen; C J Maslansky; I B Glowinski; S B Crescenzi; Wendell W Weber; G M Williams
Relationship between the genetically determined acetylator phenotype and DNA damage induced by hydralazine and 2-aminofluorene in cultured rabbit hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(4):1269-72.
1982: Wendell W Weber; D W Hein; I B Glowinski; C M King; R R Fox
Association of arylhydroxamic acid N,O-acyltransferase and genetically polymorphic N-acetyltransferase in established inbred rabbit strains.
IARC scientific publications 1982;(39):405-12.
1982: D W Hein; James G. Omichinski; J A Brewer; Wendell W Weber
A unique pharmacogenetic expression of the N-acetylation polymorphism in the inbred hamster.
The Journal of pharmacology and experimental therapeutics 1982;220(1):8-15.
1982: D W Hein; M Hirata; I B Glowinski; Wendell W Weber
Biochemical evidence for the coexistence of monomorphic and polymorphic N-acetyltransferase activities on a common protein in rabbit liver.
The Journal of pharmacology and experimental therapeutics 1982;220(1):1-7.
1981: C M King; Wendell W Weber
Formation, metabolic activation by N, O-acyltransfer, and hydrolysis of N-acyl-N-arylamine derivatives.
National Cancer Institute monograph 1981;(58):117-22.
1981: Wendell W Weber; C M King
N-Acetyltransferase and arylhydroxamic acid acyltransferase.
Methods in enzymology 1981;77():272-80.
1981: D W Hein; M Hirata; Wendell W Weber
An enzyme marker to ensure reliable determinations of human isoniazid acetylator phenotype in vitro.
Pharmacology 1981;23(4):203-10.
1980: I B Glowinski; Wendell W Weber; J M Fysh; J B Vaught; C M King
Evidence that arylhydroxamic acid N,O-acyltransferase and the genetically polymorphic N-acetyltransferase are properties of the same enzyme in rabbit liver.
The Journal of biological chemistry 1980;255(16):7883-90.
1980: E Patterson; H E Radtke; Wendell W Weber
Immunochemical studies of rabbit N-acetyltransferases.
Molecular pharmacology 1980;17(3):367-73.
1980: G S Drummond; H C Kelker; Wendell W Weber
N-acetylation of drugs. Observations on the properties of partially purified N-acetyltransferase from peripheral blood of rabbit.
The Biochemical journal 1980;187(1):157-62.
1979: R H Tannen; Wendell W Weber
Rodent models of the human isoniazid-acetylator polymorphism.
Drug metabolism and disposition: the biological fate of chemicals 1979;7(5):274-9.
1978: I B Glowinski; H E Radtke; Wendell W Weber
Genetic variation in N-acetylation of carcinogenic arylamines by human and rabbit liver.
Molecular pharmacology 1978;14(5):940-9.
1978: R R Szabadi; C A McQueen; G S Drummond; Wendell W Weber
N-Acetylation of drugs. A genetically controlled reciprocal relationship between drug N-acetylating enzymes of rabbit liver and peripheral blood cells.
Drug metabolism and disposition: the biological fate of chemicals 1978;6(1):16-20.
1976: Wendell W Weber; J N Miceli; D J Hearse; G S Drummond
N-acetylation of drugs. Pharmacogenetic studies in rabbits selected for their acetylator characteristics.
Drug metabolism and disposition: the biological fate of chemicals 1976;4(1):94-101.
1974: Wendell W Weber; W Brenner
A filter paper method for determining isoniazid acetylator phenotype.
American journal of human genetics 1974;26(4):467-73.