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Estela Area-Gomez; Ad J C de Groof; Istvan Boldogh; Thomas D Bird; Gary E Gibson; Carla M Koehler; W Haung Yu; karen duff; Michael P Yaffe; Liza A Pon; Eric A Schon
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.
Manuela Polydoro; Christopher M Acker; karen duff; Pablo E Castillo; Peter Davies
Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology.
W Haung Yu; Beatriz Dorado; Helen Yvette Figueroa; Lili Wang; Emmanuel Planel; Mark Cookson; Lorraine N Clark; karen duff
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.

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All Publications

2009: Estela Area-Gomez; Ad J C de Groof; Istvan Boldogh; Thomas D Bird; Gary E Gibson; Carla M Koehler; W Haung Yu; karen duff; Michael P Yaffe; Liza A Pon; Eric A Schon
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.
The American journal of pathology 2009;175(5):1810-6.
2009: Manuela Polydoro; Christopher M Acker; karen duff; Pablo E Castillo; Peter Davies
Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(34):10741-9.
2009: W Haung Yu; Beatriz Dorado; Helen Yvette Figueroa; Lili Wang; Emmanuel Planel; Mark Cookson; Lorraine N Clark; karen duff
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.
The American journal of pathology 2009;175(2):736-47.
2009: Emmanuel Planel; Alexis Bretteville; Li Liu; Laszlo Virag; Angela L Du; W Haung Yu; dennis dickson; Robert A Whittington; karen duff
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2595-604.
2009: Erin E Congdon; Yvette H Figueroa; Lili Wang; Galina Toneva; Edward Chang; Jeffrey Kuret; Christopher Conrad; karen duff
Inhibition of tau polymerization with a cyanine dye in two distinct model systems.
The Journal of biological chemistry 2009;284(31):20830-9.
2009: Edward Chang; Erin E Congdon; Nicolette S Honson; karen duff; Jeffrey Kuret
Structure-activity relationship of cyanine tau aggregation inhibitors.
Journal of medicinal chemistry 2009;52(11):3539-47.
2009: Alex C Kwan; karen duff; Gunnar K Gouras; Watt W Webb
Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation.
Optics express 2009;17(5):3679-89.
2008: Scott Small; karen duff
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis.
Neuron 2008;60(4):534-42.
2008: Emmanuel Planel; Pavan Krishnamurthy; Tomohiro Miyasaka; Li Liu; Mathieu Herman; Asok Kumar; Alexis Bretteville; Helen Y Figueroa; Wai Haung Yu; Robert A Whittington; Peter Davies; Akihiko Takashima; Ralph A. Nixon; karen duff
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(48):12798-807.
2008: Erin E Congdon; karen duff
Is tau aggregation toxic or protective?
Journal of Alzheimer's disease : JAD 2008;14(4):453-7.
2008: James J Choi; Shougang Wang; Truman R Brown; Scott Small; karen duff; Elisa E Konofagou
Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound.
Ultrasonic imaging 2008;30(3):189-200.
2008: Li Liu; Ian J Orozco; Emmanuel Planel; Yi Wen; Alexis Bretteville; Pavan Krishnamurthy; Lili Wang; Mathieu Herman; Helen Figueroa; W Haung Yu; Ottavio Arancio; karen duff
A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.
Neurobiology of disease 2008;31(1):46-57.
2008: Chiho Hirata-Fukae; Hui-Fang Li; Hyang-Sook Hoe; Audrey J Gray; S Sakura Minami; Katsuyoshi Hamada; Takako Niikura; Fang Hua; Hiroe Tsukagoshi-Nagai; Yuko Horikoshi-Sakuraba; Mohamed Mughal; G. William Rebeck; Frank M LaFerla; Mark P Mattson; Nobuhisa Iwata; Takaomi C Saido; William L Klein; karen duff; Paul S Aisen; Yasuji Matsuoka
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
Brain research 2008;1216():92-103.
2008: Alim Muhammad; Ingrid Flores; Hong Zhang; Rui Yu; Agnieszka Staniszewski; Emmanuel Planel; Mathieu Herman; Lingling Ho; Robert Kreber; Lawrence Honig; Barry Ganetzky; karen duff; Ottavio Arancio; Scott Small
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(20):7327-32.
2008: W Haung Yu; Yasuji Matsuoka; István Sziráki; Audrey Hashim; John LaFrancois; Henry Sershen; karen duff
Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein.
Neurochemical research 2008;33(5):902-11.
2008: Yi Wen; W Haung Yu; Bryan Maloney; Jason Bailey; Junrong Ma; Isabelle Marié; Thomas Maurin; Lili Wang; Helen Figueroa; Mathieu Herman; Pavan Krishnamurthy; Li Liu; Emmanuel Planel; Lit-Fui Lau; Debomoy K Lahiri; karen duff
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.
Neuron 2008;57(5):680-90.
2008: Yi Wen; Emmanuel Planel; Mathieu Herman; Helen Y Figueroa; Lili Wang; Li Liu; Lit-Fui Lau; W Haung Yu; karen duff
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(10):2624-32.
2008: John Q Trojanowski; karen duff; Howard Fillit; Walter J Koroshetz; Jeffrey Kuret; Diane Murphy; Larry Refolo
New directions for frontotemporal dementia drug discovery.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(2):89-93.
2008: Aidong Yuan; Asok Kumar; Corrinne M Peterhoff; karen duff; Ralph A. Nixon
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(7):1682-7.
2008: Li Liu; karen duff
A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse.
Journal of visualized experiments : JoVE 2008;(21):.
2007: Emmanuel Planel; Yoshitaka Tatebayashi; Tomohiro Miyasaka; Li Liu; Lili Wang; Mathieu Herman; W Haung Yu; Jose Luchsinger; Brian Wadzinski; karen duff; Akihiko Takashima
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(50):13635-48.
2007: Adam R Cole; Wendy Noble; Lidy van Aalten; Florian Plattner; Rena Meimaridou; Dale Hogan; Margaret Taylor; John LaFrancois; Frank J Gunn-Moore; Alexei Verkhratsky; Salvatore Oddo; Frank M LaFerla; peter giese; Kelly T Dineley; karen duff; Jill C Richardson; Shi Du Yan; Diane P Hanger; Stuart M Allan; Calum Sutherland
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.
Journal of neurochemistry 2007;103(3):1132-44.
2007: Maria F Falangola; Victor V Dyakin; Sang-Pil Lee; Adam Bogart; James S Babb; karen duff; Ralph A. Nixon; Joseph A Helpern
Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease.
NMR in biomedicine 2007;20(3):343-51.
2007: Emmanuel Planel; Karl E G Richter; Charles E Nolan; James E Finley; Li Liu; Yi Wen; Pavan Krishnamurthy; Mathieu Herman; Lili Wang; Joel B Schachter; Robert B Nelson; Lit-Fui Lau; karen duff
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(12):3090-7.
2007: Audrey J Gray; Gaku Sakaguchi; Chiharu Shiratori; Amanda Becker; John LaFrancois; Paul S Aisen; karen duff; Yasuji Matsuoka
Antibody against C-terminal Abeta selectively elevates plasma Abeta.
Neuroreport 2007;18(3):293-6.
2006: K F S Bell; Adriana Ducatenzeiler; Alfredo Ribeiro-da-Silva; karen duff; David A Bennett; A Claudio Cuello
The amyloid pathology progresses in a neurotransmitter-specific manner.
Neurobiology of aging 2006;27(11):1644-57.
2006: karen duff
Normal and abnormal tau neurobiology.
Alzheimer disease and associated disorders 2006;20(4):202-5.
2006: Mark Burns; Lilit Vardanian; Ahdeah Pajoohesh-Ganji; Lili Wang; Matthew Cooper; D Christopher Harris; karen duff; G. William Rebeck
The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.
Journal of neurochemistry 2006;98(3):792-800.
2006: Mark Burns; Urule Igbavboa; Lili Wang; W Gibson Wood; karen duff
Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice.
Neuromolecular medicine 2006;8(3):319-28.
2005: Brian A Soreghan; bingwen lu; Stefani N Thomas; karen duff; Eugene A Rakhmatulin; Tatiana Nikolskaya; Ting Chen; Austin Yang
Using proteomics and network analysis to elucidate the consequences of synaptic protein oxidation in a PS1 + AbetaPP mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2005;8(3):227-41.
2005: W Haung Yu; Ana Maria Cuervo; Asok Kumar; Corrinne M Peterhoff; Stephen D Schmidt; Ju-Hyun Lee; Panaiyur S Mohan; Marc Mercken; Mark Farmery; Lars O Tjernberg; Ying Jiang; karen duff; Yasuo Uchiyama; Jan Näslund; Paul Mathews; Anne M Cataldo; Ralph A. Nixon
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
The Journal of cell biology 2005;171(1):87-98.
2005: karen duff; Emmanuel Planel
Untangling memory deficits.
Nature medicine 2005;11(8):826-7.
2005: Samir Kumar-Singh; Daniel Pirici; Eileen McGowan; Sally Serneels; Chantal Ceuterick; John Hardy; karen duff; dennis dickson; Christine Van Broeckhoven
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.
The American journal of pathology 2005;167(2):527-43.
2005: Cathy Andorfer; Christopher M Acker; Yvonne Kress; Patrick R Hof; karen duff; Peter Davies
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(22):5446-54.
2005: Maria F Falangola; Babak A Ardekani; Sang-Pil Lee; James S Babb; Adam Bogart; Victor V Dyakin; Ralph A. Nixon; karen duff; Joseph A Helpern
Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology.
Journal of neuroscience methods 2005;144(1):91-7.
2005: Wendy Noble; Emmanuel Planel; Cindy Zehr; Vicki Olm; Jordana Meyerson; Farhana Suleman; Kate Gaynor; Lili Wang; John LaFrancois; Boris Feinstein; Mark Burns; Pavan Krishnamurthy; Yi Wen; Ratan Bhat; Jada Lewis; dennis dickson; karen duff
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6990-5.
2005: Yasuji Matsuoka; Li Shao; Manik Debnath; John LaFrancois; Amanda Becker; Audrey Gray; Paul S Aisen; Chester Mathis; William E Klunk; karen duff
An Abeta sequestration approach using non-antibody Abeta binding agents.
Current Alzheimer research 2005;2(2):265-8.
2005: Maria F Falangola; Sang-Pil Lee; Ralph A. Nixon; karen duff; Joseph A Helpern
Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice.
Neurochemical research 2005;30(2):201-5.
2004: Julia Tsai; Jaime Grutzendler; karen duff; Wen-Biao Gan
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.
Nature neuroscience 2004;7(11):1181-3.
2004: Sang-Pil Lee; Maria F Falangola; Ralph A. Nixon; karen duff; Joseph A Helpern
Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;52(3):538-44.
2004: Anne M Cataldo; Corrinne M Peterhoff; Stephen D Schmidt; Nicole B Terio; karen duff; Margaret Beard; Paul Mathews; Ralph A. Nixon
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.
Journal of neuropathology and experimental neurology 2004;63(8):821-30.
2004: Yuko Horikoshi; Gaku Sakaguchi; Amanda Becker; Audrey J Gray; karen duff; Paul S Aisen; Haruyasu Yamaguchi; Masahiro Maeda; Noriaki Kinoshita; Yasuji Matsuoka
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant.
Biochemical and biophysical research communications 2004;319(3):733-7.
2004: Mark Burns; karen duff
Brain on steroids resists neurodegeneration.
Nature medicine 2004;10(7):675-6.
2004: Hisanori Kowa; Tomoko Sakakura; Yusuke Matsuura; Tomoko Wakabayashi; D M A Mann; karen duff; Shoji Tsuji; Tadafumi Hashimoto; Takeshi Iwatsubo
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
The American journal of pathology 2004;165(1):273-81.
2004: Valentina Echeverria Moran; Adriana Ducatenzeiler; Leena Alhonen; Juhani Janne; Susan M Grant; Francisco Wandosell; Andres Muro; Francisco Baralle; Hongshan Li; karen duff; Moshe Szyf; A Claudio Cuello
Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex.
Journal of Alzheimer's disease : JAD 2004;6(3):209-19.
2004: Martin Sadowski; Joanna Pankiewicz; Henrieta Scholtzova; Yong-sheng Li; David Quartermain; karen duff; Thomas Wisniewski
Links between the pathology of Alzheimer's disease and vascular dementia.
Neurochemical research 2004;29(6):1257-66.
2004: Martin Sadowski; Joanna Pankiewicz; Henrieta Scholtzova; Yong Ji; David Quartermain; Catrin H Jensen; karen duff; Ralph A. Nixon; Rand J Gruen; Thomas Wisniewski
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.
Journal of neuropathology and experimental neurology 2004;63(5):418-28.
2004: Carlos A Saura; Se-Young Choi; Vassilios Beglopoulos; Seema Malkani; Dawei Zhang; BS Shankaranarayana Rao; Sumantra Chattarji; Raymond Kelleher; Eric R Kandel; karen duff; Alfredo Kirkwood; Jie Shen
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.
Neuron 2004;42(1):23-36.
2004: karen duff; Faraha Suleman
Transgenic mouse models of Alzheimer's disease: how useful have they been for therapeutic development?
Briefings in functional genomics & proteomics 2004;3(1):47-59.
2004: Joseph A Helpern; Sang-Pil Lee; Maria F Falangola; Victor V Dyakin; Adam Bogart; Babak A Ardekani; karen duff; Craig A Branch; Thomas Wisniewski; Mony J de Leon; Oliver T Wolf; Jacqueline O'Shea; Ralph A. Nixon
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(4):794-8.
2004: Ronald L. Klein; Wen-Lang Lin; dennis dickson; Jada Lewis; Michael Hutton; karen duff; Edwin M Meyer; Michael A King
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.
The American journal of pathology 2004;164(1):347-53.
2003: Meral Kurt; D Ceri Davies; M Kidd; karen duff; David R Howlett
Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
Neurobiology of disease 2003;14(1):89-97.
2003: Cynthia A Lemere; Edward T Spooner; John LaFrancois; Brian Malester; Chica Mori; Jodi F Leverone; Yasuji Matsuoka; Jennie W Taylor; Ronald B DeMattos; David M Holtzman; John Clements; Dennis J Selkoe; karen duff
Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.
Neurobiology of disease 2003;14(1):10-8.
2003: Youssef Wadghiri; Einar Sigurdsson; Martin Sadowski; James I Elliott; Yongsheng Li; Henrieta Scholtzova; Cheuk Tang; Gilbert Aguinaldo; Miguel Pappolla; karen duff; Thomas Wisniewski; Daniel Turnbull
Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;50(2):293-302.
2003: Cathy Andorfer; Yvonne Kress; Marisol Espinoza; Rohan de Silva; Kerry L Tucker; Yves-Alain Barde; karen duff; Peter Davies
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.
Journal of neurochemistry 2003;86(3):582-90.
2003: Mark Burns; Kate Gaynor; Vicki Olm; Marc Mercken; John LaFrancois; Lili Wang; Paul Mathews; Wendy Noble; Yasuji Matsuoka; karen duff
Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(13):5645-9.
2003: Mark Burns; karen duff
Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease.
Neurochemical research 2003;28(7):979-86.
2003: Wendy Noble; Vicki Olm; Kazuyuki Takata; Evelyn Casey; O Mary; Jordana Meyerson; Kate Gaynor; John LaFrancois; Lili Wang; Takayuki Kondo; Peter Davies; Mark Burns; Ralph A. Nixon; dennis dickson; Yasuji Matsuoka; Michael K Ahlijanian; Lit-Fui Lau; karen duff
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
Neuron 2003;38(4):555-65.
2003: Mark Burns; Wendy J Noble; Vicki Olm; Kate Gaynor; Evelyn Casey; John LaFrancois; Lili Wang; karen duff
Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques.
Brain research. Molecular brain research 2003;110(1):119-25.
2003: Suzana Petanceska; Steven DeRosa; Ali Sharma; Nichole Diaz; karen duff; Stephen G Tint; Lorenzo M Refolo; Miguel Pappolla
Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol.
Journal of molecular neuroscience : MN 2003;20(3):395-406.
2003: Morris H Baslow; Raymond F Suckow; Kate Gaynor; Kishore K Bhakoo; Neville Marks; Mitsuo Saito; Mitsuo Saito; karen duff; Yasuji Matsuoka; Martin J Berg
Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte.
Neuromolecular medicine 2003;3(2):95-104.
2003: Yasuji Matsuoka; Mitsuo Saito; John LaFrancois; Mariko Saito; Kate Gaynor; Vicki Olm; Lili Wang; Evelyn Casey; Yifan Lu; Chiharu Shiratori; Cynthia A Lemere; karen duff
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(1):29-33.
2002: karen duff; Wendy Noble; Kayte Gaynor; Yasuji Matsuoka
Organotypic slice cultures from transgenic mice as disease model systems.
Journal of molecular neuroscience : MN 2002;19(3):317-20.
2002: Mark Burns; karen duff
Cholesterol in Alzheimer's disease and tauopathy.
Annals of the New York Academy of Sciences 2002;977():367-75.
2002: Brigita Urbanc; Luis Cruz; R Le; J Sanders; Karen K. Hsiao Ashe; karen duff; H Eugene Stanley; Michael C Irizarry; Bradley T Hyman
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):13990-5.
2002: Suzana Petanceska; Steven DeRosa; Vicki Olm; Nichole Diaz; Ali Sharma; Tara Thomas-Bryant; karen duff; Miguel Pappolla; Lorenzo M Refolo
Statin therapy for Alzheimer's disease: will it work?
Journal of molecular neuroscience : MN 2002;19(1-2):155-61.
2002: Hwa Jeong Lee; Yun Zhang; Chunni Zhu; karen duff; William M Pardridge
Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(2):223-31.
2002: Hui Zheng; H Xu; S N Uljon; R Gross; K Hardy; J Gaynor; John LaFrancois; J Simpkins; Lorenzo M Refolo; Suzana Petanceska; Runsheng Wang; karen duff
Modulation of A(beta) peptides by estrogen in mouse models.
Journal of neurochemistry 2002;80(1):191-6.
2001: Lorenzo M Refolo; Miguel Pappolla; John LaFrancois; Brian Malester; Stephen D Schmidt; T Thomas-Bryant; Stephen G Tint; Runsheng Wang; Marc Mercken; Suzana Petanceska; karen duff
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.
Neurobiology of disease 2001;8(5):890-9.
2001: Meral Kurt; D Ceri Davies; M Kidd; karen duff; S C Rolph; K H Jennings; David R Howlett
Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
Experimental neurology 2001;171(1):59-71.
2001: Joseph F. Poduslo; Geoffry L Curran; Thomas M Wengenack; B Malester; karen duff
Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease.
Neurobiology of disease 2001;8(4):555-67.
2001: R Le; Luis Cruz; Brigita Urbanc; RB Knowles; Karen K. Hsiao Ashe; karen duff; Michael C Irizarry; H Eugene Stanley; Bradley T Hyman
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Journal of neuropathology and experimental neurology 2001;60(8):753-8.
2001: karen duff; M V Rao
Progress in the modeling of neurodegenerative diseases in transgenic mice.
Current opinion in neurology 2001;14(4):441-7.
2001: Yasuji Matsuoka; Miquel Vila; Sarah J Lincoln; Alison L McCormack; M Picciano; John LaFrancois; X Yu; dennis dickson; William J Langston; E McGowan; Matthew J Farrer; John Hardy; karen duff; Serge Przedborski; Donato A Di Monte
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter.
Neurobiology of disease 2001;8(3):535-9.
2001: D Hernandez; Kiminobu Sugaya; T Qu; Eileen McGowan; karen duff; Michael McKinney
Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes.
Neuroreport 2001;12(7):1377-84.
2001: Yasuji Matsuoka; M Picciano; Brian Malester; John LaFrancois; C Zehr; J M Daeschner; John A Olschowka; Maria I Fonseca; M Kerry O'Banion; Andrea J Tenner; Cynthia A Lemere; karen duff
Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.
The American journal of pathology 2001;158(4):1345-54.
2001: karen duff
Transgenic mouse models of Alzheimer's disease: phenotype and mechanisms of pathogenesis.
Biochemical Society symposium 2001;(67):195-202.
2001: Yasuji Matsuoka; M Picciano; J La Francois; karen duff
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Neuroscience 2001;104(3):609-13.
2000: Dave Morgan; David M Diamond; Paul Gottschall; Kenneth Ugen; Chad A Dickey; John Hardy; karen duff; Paul T Jantzen; Giovanni DiCarlo; Donna Wilcock; K Connor; Jaime M Hatcher; CE Hope; Marcia N Gordon; Gary W Arendash
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.
Nature 2000;408(6815):982-5.
2000: Lorenzo M Refolo; Brian Malester; John LaFrancois; Tara Bryant-Thomas; Runsheng Wang; Stephen G Tint; Kumar Sambamurti; karen duff; Miguel Pappolla
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.
Neurobiology of disease 2000;7(4):321-31.
2000: Jada Lewis; Eileen McGowan; J Rockwood; Heather L Melrose; Parimala Nacharaju; M van Slegtenhorst; Katrina Gwinn-Hardy; M Paul Murphy; Matt Baker; X Yu; karen duff; John Hardy; A Corral; Wen-Lang Lin; Shu-Hui C. Yen; dennis dickson; Peter Davies; Michael Hutton
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
Nature genetics 2000;25(4):402-5.
2000: Sam Gandy; karen duff
Post-menopausal estrogen deprivation and Alzheimer's disease.
Experimental gerontology 2000;35(4):503-11.
2000: A Takeuchi; Michael C Irizarry; karen duff; Takaomi C Saido; Karen K. Hsiao Ashe; M Hasegawa; D M A Mann; Bradley T Hyman; Takeshi Iwatsubo
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
The American journal of pathology 2000;157(1):331-9.
2000: P A Barrow; R M Empson; SJ Gladwell; C M Anderson; R Killick; X Yu; John Jefferys; karen duff
Functional phenotype in transgenic mice expressing mutant human presenilin-1.
Neurobiology of disease 2000;7(2):119-26.
2000: karen duff; H Knight; Lorenzo M Refolo; S Sanders; X Yu; M Picciano; Brian Malester; Michael Hutton; J Adamson; Michel Goedert; K Burki; Peter Davies
Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes.
Neurobiology of disease 2000;7(2):87-98.
2000: Thomas M Wengenack; Shelly Whelan; Geoffry L Curran; karen duff; Joseph F. Poduslo
Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain.
Neuroscience 2000;101(4):939-44.
1999: karen duff
Curing amyloidosis: will it work in humans?
Trends in neurosciences 1999;22(11):485-6.
1999: Harald Steiner; karen duff; Anja Capell; H Romig; MG Grim; Sarah J Lincoln; John Hardy; X Yu; M Picciano; K Fechteler; Martin Citron; R Kopan; B Pesold; S Keck; Miriam Baader; Taisuke Tomita; Takeshi Iwatsubo; Ralf Baumeister; Christian Haass
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
1999: K L Wright; Dave Morgan; X Yu; J R Goss; J M Salbaum; karen duff; Marcia N Gordon
Mice transgenic for a human amyloid precursor protein promoter-lacZ reporter construct.
Journal of molecular neuroscience : MN 1999;13(1-2):111-20.
1999: Eileen McGowan; S Sanders; Takeshi Iwatsubo; A Takeuchi; Takaomi C Saido; Cynthia Zehr; X Yu; Sacha N Uljon; Rong Wang; D M A Mann; dennis dickson; karen duff
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.
Neurobiology of disease 1999;6(4):231-44.
1999: Andrew Grover; Henry Houlden; Matt Baker; Jennifer Adamson; Jada Lewis; Guy Prihar; Stuart Pickering-Brown; karen duff; Michael Hutton
5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.
The Journal of biological chemistry 1999;274(21):15134-43.
1999: Leigh A Holcomb; Marcia N Gordon; Paul T Jantzen; Karen K. Hsiao Ashe; karen duff; Dave Morgan
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.
Behavior genetics 1999;29(3):177-85.
1999: Tak Pan Wong; T Debeir; karen duff; A Claudio Cuello
Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(7):2706-16.
1999: Jim G Begley; WENZHEN DUAN; S Chan; karen duff; Mark P Mattson
Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.
Journal of neurochemistry 1999;72(3):1030-9.
1998: karen duff
Recent work on Alzheimer's disease transgenics.
Current opinion in biotechnology 1998;9(6):561-4.
1998: John Hardy; karen duff; K G Hardy; Jordi Perez-Tur; Michael Hutton
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.
Nature neuroscience 1998;1(5):355-8.
1998: karen duff
Transgenic models for Alzheimer's disease.
Neuropathology and applied neurobiology 1998;24(2):101-3.
1998: ND Mehta; Lorenzo M Refolo; Christopher B Eckman; S Sanders; Debra Yager; Jordi Perez-Tur; Steven G Younkin; karen duff; John Hardy; Michael Hutton
Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.
Annals of neurology 1998;43(2):256-8.
1998: Leigh A Holcomb; Marcia N Gordon; Eileen McGowan; X Yu; S Benkovic; Paul T Jantzen; K Wright; I Saad; R Mueller; Dave Morgan; S Sanders; Cynthia Zehr; K O'Campo; John Hardy; CM Prada; Christopher B Eckman; Steven G Younkin; Karen K. Hsiao Ashe; karen duff
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
Nature medicine 1998;4(1):97-100.
1997: karen duff
Alzheimer transgenic mouse models come of age.
Trends in neurosciences 1997;20(7):279-80.
1996: RV Ward; J B Davis; C W Gray; A J Barton; L G Bresciani; M Caivano; V F Murphy; karen duff; Michael Hutton; John Hardy; G W Roberts; EH Karran
Presenilin-1 is processed into two major cleavage products in neuronal cell lines.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(4):293-8.
1996: karen duff; Christopher B Eckman; Cynthia Zehr; X Yu; CM Prada; Jordi Perez-Tur; Michael Hutton; Luc BUEE; Yasuo Harigaya; Debra Yager; Dave Morgan; Marcia N Gordon; Leigh A Holcomb; Lorenzo M Refolo; B Zenk; John Hardy; Steven G Younkin
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Nature 1996;383(6602):710-3.
1996: A J Barton; B W Crook; EH Karran; F Brown; D Dewar; D M A Mann; R C Pearson; D I Graham; John Hardy; Michael Hutton; karen duff; Alison Goate; Robert Clark; G W Roberts
Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(3):213-8.
1996: Guy Prihar; R A Fuldner; Jordi Perez-Tur; Sarah J Lincoln; karen duff; Richard Crook; John Hardy; C A Philips; C Venter; C Talbot; Robert Clark; Alison Goate; J Li; H Potter; EH Karran; G W Roberts; Michael Hutton; M D Adams
Structure and alternative splicing of the presenilin-2 gene.
Neuroreport 1996;7(10):1680-4.
1996: Michael Hutton; F Busfield; M Wragg; Richard Crook; Jordi Perez-Tur; Robert Clark; Guy Prihar; C Talbot; H Phillips; K Wright; Matt Baker; Corinne Lendon; karen duff; A Martinez; Henry Houlden; A Nichols; EH Karran; G Roberts; P Roques; Martin N Rossor; J C Venter; M D Adams; R T Cline; C A Phillips; Alison Goate
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.
Neuroreport 1996;7(3):801-5.
1996: karen duff; Clare Huxley
Targeting mutations to YACs by homologous recombination.
Methods in molecular biology (Clifton, N.J.) 1996;54():187-98.
1995: Jordi Perez-Tur; S Froelich; Guy Prihar; Richard Crook; Matt Baker; karen duff; M Wragg; F Busfield; Corinne Lendon; Robert Clark
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene.
Neuroreport 1995;7(1):297-301.
1995: Henry Houlden; Richard Crook; karen duff; Michael Hutton; John Collinge; P Roques; Martin N Rossor; John Hardy
Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease.
Neuroscience letters 1995;188(3):202-4.
1995: karen duff; John Hardy
Alzheimer's disease. Mouse model made.
Nature 1995;373(6514):476-7.
1994: R Rempfer; Richard Crook; Henry Houlden; karen duff; Michael Hutton; G W Roberts; R Raghavan; Robert H Perry; John Hardy
Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene.
Lancet 1994;344(8925):815.
1994: karen duff
Modeling Alzheimer's disease in transgenic mice.
The Journal of the Florida Medical Association 1994;81(9):625-8.
1994: Richard Crook; John Hardy; karen duff
Single-day apolipoprotein E genotyping.
Journal of neuroscience methods 1994;53(2):125-7.
1994: karen duff; A McGuigan; Clare Huxley; F Schulz; John Hardy
Insertion of a pathogenic mutation into a yeast artificial chromosome containing the human amyloid precursor protein gene.
Gene therapy 1994;1(1):70-5.
1993: Lars Lannfelt; R Folkesson; Abdul H Mohammed; Bengt Winblad; D Hellgren; karen duff; John Hardy
Alzheimer's disease: molecular genetics and transgenic animal models.
Behavioural brain research 1993;57(2):207-13.
1993: John Hardy; karen duff
Heterogeneity in Alzheimer's disease.
Annals of medicine 1993;25(5):437-40.
1993: J Brown; S Gydesen; S A Sorensen; A Brun; karen duff; Henry Houlden; L Fidani; S Kullkarni; Jeffrey L Cummings; Alison Goate
Exclusion mapping in familial non-specific dementia.
Dementia (Basel, Switzerland) 1993;4(3-4):163-6.
1992: Michael Mullan; Henry Houlden; M Windelspecht; L Fidani; C Lombardi; P Diaz; Martin N Rossor; Richard Crook; John Hardy; karen duff
A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.
Nature genetics 1992;2(4):340-2.