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karen duff
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20
Hardy, John
15
LaFrancois, John
14
Matsuoka, Yasuji
13
Hutton, Michael
12
Wang, Lili
11
Planel, Emmanuel
11
Nixon, Ralph A.
9
Burns, Mark
9
Yu, Haung
8
dickson, dennis
8
Refolo, Lorenzo
7
Liu, Li
7
Crook, Richard
6
Davies, Peter
6
Houlden, Henry
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All Publications
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2009: Area-Gomez Estela; de Groof Ad J C; Boldogh Istvan; Bird Thomas D; Gibson Gary E; Koehler Carla M; Yu Wai Haung; Duff Karen E; Yaffe Michael P; Pon Liza A; Schon Eric A
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.
The American journal of pathology 2009;175(5):1810-6.
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2009: Polydoro Manuela; Acker Christopher M; Duff Karen; Castillo Pablo E; Davies Peter
Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(34):10741-9.
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2009: Yu Wai Haung; Dorado Beatriz; Figueroa Helen Yvette; Wang Lili; Planel Emmanuel; Cookson Mark R; Clark Lorraine N; Duff Karen E
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.
The American journal of pathology 2009;175(2):736-47.
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2009: Planel Emmanuel; Bretteville Alexis; Liu Li; Virag Laszlo; Du Angela L; Yu Wai Haung; Dickson Dennis W; Whittington Robert A; Duff Karen E
Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(8):2595-604.
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2009: Congdon Erin E; Figueroa Yvette H; Wang Lili; Toneva Galina; Chang Edward; Kuret Jeff; Conrad Christopher; Duff Karen E
Inhibition of tau polymerization with a cyanine dye in two distinct model systems.
The Journal of biological chemistry 2009;284(31):20830-9.
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2009: Chang Edward; Congdon Erin E; Honson Nicolette S; Duff Karen E; Kuret Jeff
Structure-activity relationship of cyanine tau aggregation inhibitors.
Journal of medicinal chemistry 2009;52(11):3539-47.
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2009: Kwan Alex C; Duff Karen; Gouras Gunnar K; Webb Watt W
Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation.
Optics express 2009;17(5):3679-89.
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2008: Small Scott A; Duff Karen
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis.
Neuron 2008;60(4):534-42.
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2008: Planel Emmanuel; Krishnamurthy Pavan; Miyasaka Tomohiro; Liu Li; Herman Mathieu; Kumar Asok; Bretteville Alexis; Figueroa Helen Y; Yu Wai Haung; Whittington Robert A; Davies Peter; Takashima Akihiko; Nixon Ralph A; Duff Karen E
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(48):12798-807.
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2008: Congdon Erin E; Duff Karen E
Is tau aggregation toxic or protective?
Journal of Alzheimer's disease : JAD 2008;14(4):453-7.
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2008: Choi James J; Wang Shougang; Brown Truman R; Small Scott A; Duff Karen E K; Konofagou Elisa E
Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound.
Ultrasonic imaging 2008;30(3):189-200.
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2008: Liu Li; Orozco Ian J; Planel Emmanuel; Wen Yi; Bretteville Alexis; Krishnamurthy Pavan; Wang Lili; Herman Mathieu; Figueroa Helen; Yu W Haung; Arancio Ottavio; Duff Karen
A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.
Neurobiology of disease 2008;31(1):46-57.
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2008: Hirata-Fukae Chiho; Li Hui-Fang; Hoe Hyang-Sook; Gray Audrey J; Minami S Sakura; Hamada Katsuyoshi; Niikura Takako; Hua Fang; Tsukagoshi-Nagai Hiroe; Horikoshi-Sakuraba Yuko; Mughal Mohamed; Rebeck G William; LaFerla Frank M; Mattson Mark P; Iwata Nobuhisa; Saido Takaomi C; Klein William L; Duff Karen E; Aisen Paul S; Matsuoka Yasuji
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
Brain research 2008;1216():92-103.
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2008: Muhammad Alim; Flores Ingrid; Zhang Hong; Yu Rui; Staniszewski Agnieszka; Planel Emmanuel; Herman Mathieu; Ho Lingling; Kreber Robert; Honig Lawrence S; Ganetzky Barry; Duff Karen; Arancio Ottavio; Small Scott A
Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(20):7327-32.
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2008: Yu Wai Haung; Matsuoka Yasuji; Sziráki István; Hashim Audrey; Lafrancois John; Sershen Henry; Duff Karen E
Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein.
Neurochemical research 2008;33(5):902-11.
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2008: Trojanowski John Q; Duff Karen; Fillit Howard; Koroshetz Walter; Kuret Jeff; Murphy Diane; Refolo Larry;
New directions for frontotemporal dementia drug discovery.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(2):89-93.
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2008: Wen Yi; Yu W Haung; Maloney Bryan; Bailey Jason; Ma Junrong; Marié Isabelle; Maurin Thomas; Wang Lili; Figueroa Helen; Herman Mathieu; Krishnamurthy Pavan; Liu Li; Planel Emmanuel; Lau Lit-Fui; Lahiri Debomoy K; Duff Karen
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.
Neuron 2008;57(5):680-90.
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2008: Wen Yi; Planel Emmanuel; Herman Mathieu; Figueroa Helen Y; Wang Lili; Liu Li; Lau Lit-Fui; Yu Wai Haung; Duff Karen E
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(10):2624-32.
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2008: Yuan Aidong; Kumar Asok; Peterhoff Corrinne; Duff Karen; Nixon Ralph A
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(7):1682-7.
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2008: Liu Li; Duff Karen
A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse.
Journal of visualized experiments : JoVE 2008;(21):.
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2007: Planel Emmanuel; Tatebayashi Yoshitaka; Miyasaka Tomohiro; Liu Li; Wang Lili; Herman Mathieu; Yu W Haung; Luchsinger Jose A; Wadzinski Brian; Duff Karen E; Takashima Akihiko
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(50):13635-48.
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2007: Cole Adam R; Noble Wendy; van Aalten Lidy; Plattner Florian; Meimaridou Rena; Hogan Dale; Taylor Margaret; LaFrancois John; Gunn-Moore Frank; Verkhratsky Alex; Oddo Salvatore; LaFerla Frank; Giese K Peter; Dineley Kelly T; Duff Karen; Richardson Jill C; Yan Shi Du; Hanger Diane P; Allan Stuart M; Sutherland Calum
Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.
Journal of neurochemistry 2007;103(3):1132-44.
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2007: Falangola M F; Dyakin V V; Lee S P; Bogart A; Babb J S; Duff K; Nixon R; Helpern J A
Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease.
NMR in biomedicine 2007;20(3):343-51.
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2007: Planel Emmanuel; Richter Karl E G; Nolan Charles E; Finley James E; Liu Li; Wen Yi; Krishnamurthy Pavan; Herman Mathieu; Wang Lili; Schachter Joel B; Nelson Robert B; Lau Lit-Fui; Duff Karen E
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(12):3090-7.
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2007: Gray Audrey J; Sakaguchi Gaku; Shiratori Chiharu; Becker Amanda G; LaFrancois John; Aisen Paul S; Duff Karen; Matsuoka Yasuji
Antibody against C-terminal Abeta selectively elevates plasma Abeta.
Neuroreport 2007;18(3):293-6.
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2006: Bell Karen F S; Ducatenzeiler Adriana; Ribeiro-da-Silva Alfredo; Duff Karen; Bennett David A; Cuello A Claudio
The amyloid pathology progresses in a neurotransmitter-specific manner.
Neurobiology of aging 2006;27(11):1644-57.
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2006: Duff Karen
Normal and abnormal tau neurobiology.
Alzheimer disease and associated disorders 2006;20(4):202-5.
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2006: Burns Mark P; Vardanian Lilit; Pajoohesh-Ganji Ahdeah; Wang Lili; Cooper Matthew; Harris Donnie C; Duff Karen; Rebeck G William
The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.
Journal of neurochemistry 2006;98(3):792-800.
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2006: Burns Mark P; Igbavboa Urule; Wang Lili; Wood W Gibson; Duff Karen
Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice.
Neuromolecular medicine 2006;8(3):319-28.
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2005: Soreghan Brian A; Lu Bing-Wen; Thomas Stefani N; Duff Karen; Rakhmatulin Eugene A; Nikolskaya Tatiana; Chen Ting; Yang Austin J
Using proteomics and network analysis to elucidate the consequences of synaptic protein oxidation in a PS1 + AbetaPP mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2005;8(3):227-41.
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2005: Yu W Haung; Cuervo Ana Maria; Kumar Asok; Peterhoff Corrinne M; Schmidt Stephen D; Lee Ju-Hyun; Mohan Panaiyur S; Mercken Marc; Farmery Mark R; Tjernberg Lars O; Jiang Ying; Duff Karen; Uchiyama Yasuo; Näslund Jan; Mathews Paul M; Cataldo Anne M; Nixon Ralph A
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
The Journal of cell biology 2005;171(1):87-98.
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2005: Duff Karen; Planel Emmanuel
Untangling memory deficits.
Nature medicine 2005;11(8):826-7.
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2005: Kumar-Singh Samir; Pirici Daniel; McGowan Eileen; Serneels Sally; Ceuterick Chantal; Hardy John; Duff Karen; Dickson Dennis; Van Broeckhoven Christine
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.
The American journal of pathology 2005;167(2):527-43.
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2005: Andorfer Cathy; Acker Christopher M; Kress Yvonne; Hof Patrick R; Duff Karen; Davies Peter
Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(22):5446-54.
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2005: Noble Wendy; Planel Emmanuel; Zehr Cindy; Olm Vicki; Meyerson Jordana; Suleman Farhana; Gaynor Kate; Wang Lili; LaFrancois John; Feinstein Boris; Burns Mark; Krishnamurthy Pavan; Wen Yi; Bhat Ratan; Lewis Jada; Dickson Dennis; Duff Karen
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6990-5.
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2005: Falangola M F; Ardekani B A; Lee S-P; Babb J S; Bogart A; Dyakin V V; Nixon R; Duff K; Helpern J A
Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology.
Journal of neuroscience methods 2005;144(1):91-7.
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2005: Matsuoka Yasuji; Shao Li; Debnath Manik; Lafrancois John; Becker Amanda; Gray Audrey; Aisen Paul; Mathis Chester; Klunk William; Duff Karen
An Abeta sequestration approach using non-antibody Abeta binding agents.
Current Alzheimer research 2005;2(2):265-8.
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2005: Falangola Maria F; Lee Sang-Pil; Nixon Ralph A; Duff Karen; Helpern Joseph A
Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice.
Neurochemical research 2005;30(2):201-5.
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2004: Tsai Julia; Grutzendler Jaime; Duff Karen; Gan Wen-Biao
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.
Nature neuroscience 2004;7(11):1181-3.
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2004: Lee Sang-Pil; Falangola Maria F; Nixon Ralph A; Duff Karen; Helpern Joseph A
Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;52(3):538-44.
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2004: Cataldo Anne M; Peterhoff Corrinne M; Schmidt Stephen D; Terio Nicole B; Duff Karen; Beard Margaret; Mathews Paul M; Nixon Ralph A
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.
Journal of neuropathology and experimental neurology 2004;63(8):821-30.
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2004: Burns Mark P; Duff Karen
Brain on steroids resists neurodegeneration.
Nature medicine 2004;10(7):675-6.
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2004: Kowa Hisatomo; Sakakura Tomoko; Matsuura Yusuke; Wakabayashi Tomoko; Mann David M A; Duff Karen; Tsuji Shoji; Hashimoto Tadafumi; Iwatsubo Takeshi
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
The American journal of pathology 2004;165(1):273-81.
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2004: Horikoshi Yuko; Sakaguchi Gaku; Becker Amanda G; Gray Audrey J; Duff Karen; Aisen Paul S; Yamaguchi Haruyasu; Maeda Masahiro; Kinoshita Noriaki; Matsuoka Yasuji
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant.
Biochemical and biophysical research communications 2004;319(3):733-7.
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2004: Echeverria Valentina; Ducatenzeiler Adriana; Alhonen Leena; Janne Juhani; Grant Susan M; Wandosell Francisco; Muro Andres; Baralle Francisco; Li Hongshan; Duff Karen; Szyf Moshe; Cuello A Claudio
Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex.
Journal of Alzheimer's disease : JAD 2004;6(3):209-19.
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2004: Sadowski Marcin; Pankiewicz Joanna; Scholtzova Henrieta; Li Yong-sheng; Quartermain David; Duff Karen; Wisniewski Thomas
Links between the pathology of Alzheimer's disease and vascular dementia.
Neurochemical research 2004;29(6):1257-66.
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2004: Sadowski Marcin; Pankiewicz Joanna; Scholtzova Henrieta; Ji Yong; Quartermain David; Jensen Catrin H; Duff Karen; Nixon Ralph A; Gruen Rand J; Wisniewski Thomas
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.
Journal of neuropathology and experimental neurology 2004;63(5):418-28.
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2004: Duff Karen; Suleman Faraha
Transgenic mouse models of Alzheimer's disease: how useful have they been for therapeutic development?
Briefings in functional genomics & proteomics 2004;3(1):47-59.
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2004: Saura Carlos A; Choi Se-Young; Beglopoulos Vassilios; Malkani Seema; Zhang Dawei; Shankaranarayana Rao B S; Chattarji Sumantra; Kelleher Raymond J; Kandel Eric R; Duff Karen; Kirkwood Alfredo; Shen Jie
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.
Neuron 2004;42(1):23-36.
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2004: Helpern Joseph A; Lee Sang-Pil; Falangola Maria F; Dyakin Victor V; Bogart Adam; Ardekani Babak; Duff Karen; Branch Craig; Wisniewski Thomas; de Leon Mony J; Wolf Oliver; O'Shea Jacqueline; Nixon Ralph A
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(4):794-8.
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2004: Klein Ronald L; Lin Wen-Lang; Dickson Dennis W; Lewis Jada; Hutton Michael; Duff Karen; Meyer Edwin M; King Michael A
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.
The American journal of pathology 2004;164(1):347-53.
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2003: Kurt M A; Davies D C; Kidd M; Duff K; Howlett D R
Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
Neurobiology of disease 2003;14(1):89-97.
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2003: Lemere Cynthia A; Spooner Edward T; LaFrancois John; Malester Brian; Mori Chica; Leverone Jodi F; Matsuoka Yasuji; Taylor Jennie W; DeMattos Ronald B; Holtzman David M; Clements John D; Selkoe Dennis J; Duff Karen E
Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.
Neurobiology of disease 2003;14(1):10-8.
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2003: Wadghiri Youssef Zaim; Sigurdsson Einar M; Sadowski Marcin; Elliott James I; Li Yongsheng; Scholtzova Henrieta; Tang Cheuk Ying; Aguinaldo Gilbert; Pappolla Miguel; Duff Karen; Wisniewski Thomas; Turnbull Daniel H
Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;50(2):293-302.
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2003: Andorfer Cathy; Kress Yvonne; Espinoza Marisol; de Silva Rohan; Tucker Kerry L; Barde Yves-Alain; Duff Karen; Davies Peter
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.
Journal of neurochemistry 2003;86(3):582-90.
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2003: Burns Mark; Gaynor Kate; Olm Vicki; Mercken Marc; LaFrancois John; Wang Lili; Mathews Paul M; Noble Wendy; Matsuoka Yasuji; Duff Karen
Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(13):5645-9.
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2003: Burns Mark; Duff Karen
Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease.
Neurochemical research 2003;28(7):979-86.
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2003: Noble Wendy; Olm Vicki; Takata Kazuyuki; Casey Evelyn; Mary O; Meyerson Jordana; Gaynor Kate; LaFrancois John; Wang Lili; Kondo Takayuki; Davies Peter; Burns Mark; Veeranna; Nixon Ralph; Dickson Dennis; Matsuoka Yasuji; Ahlijanian Michael; Lau Lit-Fui; Duff Karen
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
Neuron 2003;38(4):555-65.
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2003: Burns Mark P; Noble Wendy J; Olm Vicki; Gaynor Kate; Casey Evelyn; LaFrancois John; Wang Lili; Duff Karen
Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques.
Brain research. Molecular brain research 2003;110(1):119-25.
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2003: Matsuoka Yasuji; Saito Mitsuo; LaFrancois John; Saito Mariko; Gaynor Kate; Olm Vicki; Wang Lili; Casey Evelyn; Lu Yifan; Shiratori Chiharu; Lemere Cynthia; Duff Karen
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(1):29-33.
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2003: Petanceska Suzana S; DeRosa Steven; Sharma Ali; Diaz Nichole; Duff Karen; Tint Steven G; Refolo Lorenzo M; Pappolla Miguel
Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol.
Journal of molecular neuroscience : MN 2003;20(3):395-406.
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2003: Baslow Morris H; Suckow Raymond F; Gaynor Kate; Bhakoo Kishore K; Marks Neville; Saito Mariko; Saito Mitsuo; Duff Karen; Matsuoka Yasuji; Berg Martin J
Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte.
Neuromolecular medicine 2003;3(2):95-104.
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2002: Duff Karen; Noble Wendy; Gaynor Kayte; Matsuoka Yasuji
Organotypic slice cultures from transgenic mice as disease model systems.
Journal of molecular neuroscience : MN 2002;19(3):317-20.
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2002: Burns Mark; Duff Karen
Cholesterol in Alzheimer's disease and tauopathy.
Annals of the New York Academy of Sciences 2002;977():367-75.
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2002: Urbanc B; Cruz L; Le R; Sanders J; Ashe K Hsiao; Duff K; Stanley H E; Irizarry M C; Hyman B T
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):13990-5.
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2002: Petanceska Suzana S; DeRosa Steven; Olm Vicki; Diaz Nichole; Sharma Ali; Thomas-Bryant Tara; Duff Karen; Pappolla Miguel; Refolo Lorenzo M
Statin therapy for Alzheimer's disease: will it work?
Journal of molecular neuroscience : MN 2002;19(1-2):155-61.
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2002: Lee Hwa Jeong; Zhang Yun; Zhu Chunni; Duff Karen; Pardridge William M
Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(2):223-31.
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2002: Zheng H; Xu H; Uljon S N; Gross R; Hardy K; Gaynor J; Lafrancois J; Simpkins J; Refolo L M; Petanceska S; Wang R; Duff K
Modulation of A(beta) peptides by estrogen in mouse models.
Journal of neurochemistry 2002;80(1):191-6.
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2001: Refolo L M; Pappolla M A; LaFrancois J; Malester B; Schmidt S D; Thomas-Bryant T; Tint G S; Wang R; Mercken M; Petanceska S S; Duff K E
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.
Neurobiology of disease 2001;8(5):890-9.
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2001: Kurt M A; Davies D C; Kidd M; Duff K; Rolph S C; Jennings K H; Howlett D R
Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
Experimental neurology 2001;171(1):59-71.
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2001: Poduslo J F; Curran G L; Wengenack T M; Malester B; Duff K
Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease.
Neurobiology of disease 2001;8(4):555-67.
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2001: Le R; Cruz L; Urbanc B; Knowles R B; Hsiao-Ashe K; Duff K; Irizarry M C; Stanley H E; Hyman B T
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Journal of neuropathology and experimental neurology 2001;60(8):753-8.
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2001: Duff K; Rao M V
Progress in the modeling of neurodegenerative diseases in transgenic mice.
Current opinion in neurology 2001;14(4):441-7.
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2001: Matsuoka Y; Vila M; Lincoln S; McCormack A; Picciano M; LaFrancois J; Yu X; Dickson D; Langston W J; McGowan E; Farrer M; Hardy J; Duff K; Przedborski S; Di Monte D A
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter.
Neurobiology of disease 2001;8(3):535-9.
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2001: Hernandez D; Sugaya K; Qu T; McGowan E; Duff K; McKinney M
Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes.
Neuroreport 2001;12(7):1377-84.
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2001: Matsuoka Y; Picciano M; Malester B; LaFrancois J; Zehr C; Daeschner J M; Olschowka J A; Fonseca M I; O'Banion M K; Tenner A J; Lemere C A; Duff K
Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.
The American journal of pathology 2001;158(4):1345-54.
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2001: Duff K
Transgenic mouse models of Alzheimer's disease: phenotype and mechanisms of pathogenesis.
Biochemical Society symposium 2001;(67):195-202.
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2001: Matsuoka Y; Picciano M; La Francois J; Duff K
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Neuroscience 2001;104(3):609-13.
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2000: Morgan D; Diamond D M; Gottschall P E; Ugen K E; Dickey C; Hardy J; Duff K; Jantzen P; DiCarlo G; Wilcock D; Connor K; Hatcher J; Hope C; Gordon M; Arendash G W
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.
Nature 2000;408(6815):982-5.
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2000: Refolo L M; Malester B; LaFrancois J; Bryant-Thomas T; Wang R; Tint G S; Sambamurti K; Duff K; Pappolla M A
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.
Neurobiology of disease 2000;7(4):321-31.
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2000: Lewis J; McGowan E; Rockwood J; Melrose H; Nacharaju P; Van Slegtenhorst M; Gwinn-Hardy K; Paul Murphy M; Baker M; Yu X; Duff K; Hardy J; Corral A; Lin W L; Yen S H; Dickson D W; Davies P; Hutton M
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
Nature genetics 2000;25(4):402-5.
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2000: Gandy S; Duff K
Post-menopausal estrogen deprivation and Alzheimer's disease.
Experimental gerontology 2000;35(4):503-11.
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2000: Takeuchi A; Irizarry M C; Duff K; Saido T C; Hsiao Ashe K; Hasegawa M; Mann D M; Hyman B T; Iwatsubo T
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
The American journal of pathology 2000;157(1):331-9.
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2000: Barrow P A; Empson R M; Gladwell S J; Anderson C M; Killick R; Yu X; Jefferys J G; Duff K
Functional phenotype in transgenic mice expressing mutant human presenilin-1.
Neurobiology of disease 2000;7(2):119-26.
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2000: Duff K; Knight H; Refolo L M; Sanders S; Yu X; Picciano M; Malester B; Hutton M; Adamson J; Goedert M; Burki K; Davies P
Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes.
Neurobiology of disease 2000;7(2):87-98.
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2000: Wengenack T M; Whelan S; Curran G L; Duff K E; Poduslo J F
Quantitative histological analysis of amyloid deposition in Alzheimer's double transgenic mouse brain.
Neuroscience 2000;101(4):939-44.
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1999: Duff K
Curing amyloidosis: will it work in humans?
Trends in neurosciences 1999;22(11):485-6.
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1999: Steiner H; Duff K; Capell A; Romig H; Grim M G; Lincoln S; Hardy J; Yu X; Picciano M; Fechteler K; Citron M; Kopan R; Pesold B; Keck S; Baader M; Tomita T; Iwatsubo T; Baumeister R; Haass C
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
The Journal of biological chemistry 1999;274(40):28669-73.
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1999: Wright K L; Morgan D G; Yu X; Goss J R; Salbaum J M; Duff K; Gordon M N
Mice transgenic for a human amyloid precursor protein promoter-lacZ reporter construct.
Journal of molecular neuroscience : MN 1999;13(1-2):111-20.
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1999: McGowan E; Sanders S; Iwatsubo T; Takeuchi A; Saido T; Zehr C; Yu X; Uljon S; Wang R; Mann D; Dickson D; Duff K
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.
Neurobiology of disease 1999;6(4):231-44.
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1999: Holcomb L A; Gordon M N; Jantzen P; Hsiao K; Duff K; Morgan D
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.
Behavior genetics 1999;29(3):177-85.
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1999: Grover A; Houlden H; Baker M; Adamson J; Lewis J; Prihar G; Pickering-Brown S; Duff K; Hutton M
5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.
The Journal of biological chemistry 1999;274(21):15134-43.
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1999: Wong T P; Debeir T; Duff K; Cuello A C
Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(7):2706-16.
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1999: Begley J G; Duan W; Chan S; Duff K; Mattson M P
Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.
Journal of neurochemistry 1999;72(3):1030-9.
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1998: Duff K
Recent work on Alzheimer's disease transgenics.
Current opinion in biotechnology 1998;9(6):561-4.
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1998: Hardy J; Duff K; Hardy K G; Perez-Tur J; Hutton M
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.
Nature neuroscience 1998;1(5):355-8.
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1998: Duff K
Transgenic models for Alzheimer's disease.
Neuropathology and applied neurobiology 1998;24(2):101-3.
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1998: Mehta N D; Refolo L M; Eckman C; Sanders S; Yager D; Perez-Tur J; Younkin S; Duff K; Hardy J; Hutton M
Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.
Annals of neurology 1998;43(2):256-8.
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1998: Holcomb L; Gordon M N; McGowan E; Yu X; Benkovic S; Jantzen P; Wright K; Saad I; Mueller R; Morgan D; Sanders S; Zehr C; O'Campo K; Hardy J; Prada C M; Eckman C; Younkin S; Hsiao K; Duff K
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
Nature medicine 1998;4(1):97-100.
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1997: Duff K
Alzheimer transgenic mouse models come of age.
Trends in neurosciences 1997;20(7):279-80.
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1996: Ward R V; Davis J B; Gray C W; Barton A J; Bresciani L G; Caivano M; Murphy V F; Duff K; Hutton M; Hardy J; Roberts G W; Karran E H
Presenilin-1 is processed into two major cleavage products in neuronal cell lines.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(4):293-8.
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1996: Duff K; Eckman C; Zehr C; Yu X; Prada C M; Perez-tur J; Hutton M; Buee L; Harigaya Y; Yager D; Morgan D; Gordon M N; Holcomb L; Refolo L; Zenk B; Hardy J; Younkin S
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Nature 1996;383(6602):710-3.
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1996: Barton A J; Crook B W; Karran E H; Brown F; Dewar D; Mann D M; Pearson R C; Graham D I; Hardy J; Hutton M; Duff K; Goate A M; Clark R F; Roberts G W
Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(3):213-8.
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1996: Prihar G; Fuldner R A; Perez-Tur J; Lincoln S; Duff K; Crook R; Hardy J; Philips C A; Venter C; Talbot C; Clark R F; Goate A; Li J; Potter H; Karran E; Roberts G W; Hutton M; Adams M D
Structure and alternative splicing of the presenilin-2 gene.
Neuroreport 1996;7(10):1680-4.
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1996: Hutton M; Busfield F; Wragg M; Crook R; Perez-Tur J; Clark R F; Prihar G; Talbot C; Phillips H; Wright K; Baker M; Lendon C; Duff K; Martinez A; Houlden H; Nichols A; Karran E; Roberts G; Roques P; Rossor M; Venter J C; Adams M D; Cline R T; Phillips C A; Goate A
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.
Neuroreport 1996;7(3):801-5.
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1996: Duff K; Huxley C
Targeting mutations to YACs by homologous recombination.
Methods in molecular biology (Clifton, N.J.) 1996;54():187-98.
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1995: Perez-Tur J; Froelich S; Prihar G; Crook R; Baker M; Duff K; Wragg M; Busfield F; Lendon C; Clark R F
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene.
Neuroreport 1995;7(1):297-301.
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1995: Houlden H; Crook R; Duff K; Hutton M; Collinge J; Roques P; Rossor M; Hardy J
Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease.
Neuroscience letters 1995;188(3):202-4.
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1995: Duff K; Hardy J
Alzheimer's disease. Mouse model made.
Nature 1995;373(6514):476-7.
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1994: Duff K
Modeling Alzheimer's disease in transgenic mice.
The Journal of the Florida Medical Association 1994;81(9):625-8.
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1994: Rempfer R; Crook R; Houlden H; Duff K; Hutton M; Roberts G W; Raghavan R; Perry R; Hardy J
Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene.
Lancet 1994;344(8925):815.
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1994: Crook R; Hardy J; Duff K
Single-day apolipoprotein E genotyping.
Journal of neuroscience methods 1994;53(2):125-7.
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1994: Duff K; McGuigan A; Huxley C; Schulz F; Hardy J
Insertion of a pathogenic mutation into a yeast artificial chromosome containing the human amyloid precursor protein gene.
Gene therapy 1994;1(1):70-5.
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1993: Lannfelt L; Folkesson R; Mohammed A H; Winblad B; Hellgren D; Duff K; Hardy J
Alzheimer's disease: molecular genetics and transgenic animal models.
Behavioural brain research 1993;57(2):207-13.
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1993: Hardy J; Duff K
Heterogeneity in Alzheimer's disease.
Annals of medicine 1993;25(5):437-40.
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1993: Brown J; Gydesen S; Sorensen S A; Brun A; Duff K; Houlden H; Fidani L; Kullkarni S; Cummings J; Goate A
Exclusion mapping in familial non-specific dementia.
Dementia (Basel, Switzerland) 1993;4(3-4):163-6.
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1992: Mullan M; Houlden H; Windelspecht M; Fidani L; Lombardi C; Diaz P; Rossor M; Crook R; Hardy J; Duff K
A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.
Nature genetics 1992;2(4):340-2.
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