Inge Grundke-Iqbal

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Deng Yanqiu; Li Bin; Liu Ying; Iqbal Khalid; Grundke-Iqbal Inge; Gong Cheng-Xin
Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease.
Liu Ying; Liu Fei; Grundke-Iqbal Inge; Iqbal Khalid; Gong Cheng-Xin
Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease.
Liu Fei; Shi Jianhua; Tanimukai Hitoshi; Gu Jinhua; Gu Jianlan; Grundke-Iqbal Inge; Iqbal Khalid; Gong Cheng-Xin
Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease.

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All Publications

2009: Deng Yanqiu; Li Bin; Liu Ying; Iqbal Khalid; Grundke-Iqbal Inge; Gong Cheng-Xin
Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease.
The American journal of pathology 2009;175(5):2089-98.
2009: Liu Ying; Liu Fei; Grundke-Iqbal Inge; Iqbal Khalid; Gong Cheng-Xin
Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease.
Journal of neurochemistry 2009;111(1):242-9.
2009: Liu Fei; Shi Jianhua; Tanimukai Hitoshi; Gu Jinhua; Gu Jianlan; Grundke-Iqbal Inge; Iqbal Khalid; Gong Cheng-Xin
Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease.
Brain : a journal of neurology 2009;132(Pt 7):1820-32.
2009: Iqbal Khalid; Liu Fei; Gong Cheng-Xin; Alonso Alejandra Del C; Grundke-Iqbal Inge
Mechanisms of tau-induced neurodegeneration.
Acta neuropathologica 2009;118(1):53-69.
2009: Tanimukai Hitoshi; Kudo Takashi; Tanaka Toshihisa; Grundke-Iqbal Inge; Iqbal Khalid; Takeda Masatoshi
Novel therapeutic strategies for neurodegenerative disease.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2009;9(2):103-9.
2009: Run Xiaoqin; Liang Zhihou; Zhang Lan; Iqbal Khalid; Grundke-Iqbal Inge; Gong Cheng-Xin
Anesthesia induces phosphorylation of tau.
Journal of Alzheimer's disease : JAD 2009;16(3):619-26.
2009: Yu Yang; Run Xiaoqin; Liang Zhihou; Li Yi; Liu Fei; Liu Ying; Iqbal Khalid; Grundke-Iqbal Inge; Gong Cheng-Xin
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry 2009;108(6):1480-94.
2008: Iqbal Khalid; Chohan M Omar; Grundke-Iqbal Inge
Stratification of patients is the way to go to develop neuroprotective/disease-modifying drugs for Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2008;15(2):339-45.
2008: Shi Jianhua; Zhang Tianyi; Zhou Chunlei; Chohan Muhammad Omar; Gu Xiaosong; Wegiel Jerzy; Zhou Jianhua; Hwang Yu-Wen; Iqbal Khalid; Grundke-Iqbal Inge; Gong Cheng-Xin; Liu Fei
Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome.
The Journal of biological chemistry 2008;283(42):28660-9.
2008: Liu Fei; Liang Zhihou; Wegiel Jerzy; Hwang Yu-Wen; Iqbal Khalid; Grundke-Iqbal Inge; Ramakrishna Narayan; Gong Cheng-Xin
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(9):3224-33.
2008: Alonso Alejandra del C; Li Ben; Grundke-Iqbal Inge; Iqbal Khalid
Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies.
Current Alzheimer research 2008;5(4):375-84.
2008: Iqbal Khalid; Alonso Alejandra del C; Grundke-Iqbal Inge
Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly.
Journal of Alzheimer's disease : JAD 2008;14(4):365-70.
2008: Wang Xiao-Chuan; Zhang Yin-Chun; Chatterjie Nithiananda; Grundke-Iqbal Inge; Iqbal Khalid; Wang Jian-Zhi
Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells.
Neurochemical research 2008;33(6):1138-44.
2008: Liang Zhihou; Liu Fei; Iqbal Khalid; Grundke-Iqbal Inge; Wegiel Jerzy; Gong Cheng-Xin
Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.
Journal of Alzheimer's disease : JAD 2008;13(3):295-302.
2008: Chen She; Li Bin; Grundke-Iqbal Inge; Iqbal Khalid
I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A.
The Journal of biological chemistry 2008;283(16):10513-21.
2008: Iqbal K; Grundke-Iqbal I
Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.
Journal of cellular and molecular medicine 2008;12(1):38-55.
2008: Liu Ying; Liu Fei; Iqbal Khalid; Grundke-Iqbal Inge; Gong Cheng-Xin
Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease.
FEBS letters 2008;582(2):359-64.
2008: Li Bin; Yamamori Hidenaga; Tatebayashi Yoshitaka; Shafit-Zagardo Bridget; Tanimukai Hitoshi; Chen She; Iqbal Khalid; Grundke-Iqbal Inge
Failure of neuronal maturation in Alzheimer disease dentate gyrus.
Journal of neuropathology and experimental neurology 2008;67(1):78-84.
2008: Deng Yanqiu; Li Bin; Liu Fei; Iqbal Khalid; Grundke-Iqbal Inge; Brandt Roland; Gong Cheng-Xin
Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):138-45.
2007: Liu Fei; Li Bin; Tung E-Jan; Grundke-Iqbal Inge; Iqbal Khalid; Gong Cheng-Xin
Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation.
The European journal of neuroscience 2007;26(12):3429-36.
2007: Liang Zhihou; Liu Fei; Grundke-Iqbal Inge; Iqbal Khalid; Gong Cheng-Xin
Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain.
Journal of neurochemistry 2007;103(6):2462-70.
2007: Iqbal K; Grundke-Iqbal I
Developing pharmacological therapies for Alzheimer disease.
Cellular and molecular life sciences : CMLS 2007;64(17):2234-44.
2007: Chen Honghui; Tung Yunn-Chyn; Li Bin; Iqbal Khalid; Grundke-Iqbal Inge
Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis.
Neurobiology of aging 2007;28(8):1148-62.
2007: Yamamori Hidenaga; Khatoon Sabiha; Grundke-Iqbal Inge; Blennow Kaj; Ewers Michael; Hampel Harald; Iqbal Khalid
Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification.
Neuroscience letters 2007;418(2):186-9.
2007: Li Bin; Chohan Muhammad Omar; Grundke-Iqbal Inge; Iqbal Khalid
Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.
Acta neuropathologica 2007;113(5):501-11.
2007: Wang Jian-Zhi; Grundke-Iqbal Inge; Iqbal Khalid
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.
The European journal of neuroscience 2007;25(1):59-68.
2006: Sengupta Amitabha; Grundke-Iqbal Inge; Iqbal Khalid
Regulation of phosphorylation of tau by protein kinases in rat brain.
Neurochemical research 2006;31(12):1473-80.
2006: Liu Fei; Liang Zhihou; Shi Jianhua; Yin Dongmei; El-Akkad Ezzat; Grundke-Iqbal Inge; Iqbal Khalid; Gong Cheng-Xin
PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.
FEBS letters 2006;580(26):6269-74.
2006: Sengupta Amitabha; Novak Michal; Grundke-Iqbal Inge; Iqbal Khalid
Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level.
FEBS letters 2006;580(25):5925-33.
2006: Alonso Alejandra del C; Li Bin; Grundke-Iqbal Inge; Iqbal Khalid
Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8864-9.
2006: Zhou Xin-Wen; Li Xu; Bjorkdahl Cecilia; Sjogren Magnus J; Alafuzoff Irina; Soininen Hilkka; Grundke-Iqbal Inge; Iqbal Khalid; Winblad Bengt; Pei Jin-Jing
Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains.
Neurobiology of disease 2006;22(3):657-68.
2006: Gong Cheng-Xin; Liu Fei; Grundke-Iqbal Inge; Iqbal Khalid
Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.
Journal of Alzheimer's disease : JAD 2006;9(1):1-12.
2006: Rahman A; Grundke-Iqbal I; Iqbal K
PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(2):219-30.
2006: Grundke-Iqbal I; Rolkova G; Konstekova E; Iqbal K
Biological markers in Alzheimer's disease.
Bratislavské lekárske listy 2006;107(9-10):359-65.
2006: Gong Cheng-Xin; Liu Fei; Grundke-Iqbal Inge; Iqbal Khalid
Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target.
Journal of biomedicine & biotechnology 2006;2006(3):31825.
2006: Iqbal Khalid; Grundke-Iqbal Inge
Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):219-42.
2005: Iqbal Khalid; Flory Michael; Khatoon Sabiha; Soininen Hilkka; Pirttila Tuula; Lehtovirta Maarit; Alafuzoff Irina; Blennow Kaj; Andreasen Niels; Vanmechelen Eugeen; Grundke-Iqbal Inge
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers.
Annals of neurology 2005;58(5):748-57.
2005: Liu Fei; Grundke-Iqbal Inge; Iqbal Khalid; Oda Yoshiya; Tomizawa Kazuhito; Gong Cheng-Xin
Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain.
The Journal of biological chemistry 2005;280(45):37755-62.
2005: Liu Fei; Grundke-Iqbal Inge; Iqbal Khalid; Gong Cheng-Xin
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.
The European journal of neuroscience 2005;22(8):1942-50.
2005: Chohan M O; Haque N; Alonso A; El-Akkad E; Grundke-Iqbal I; Grover A; Iqbal K
Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(8):1035-47.
2005: Ruben George C; Wang Jian-Zhi; Iqbal Khalid; Grundke-Iqbal Inge
Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation.
Microscopy research and technique 2005;67(3-4):175-95.
2005: Iqbal Khalid; Grundke-Iqbal Inge
Pharmacological approaches of neurofibrillary degeneration.
Current Alzheimer research 2005;2(3):335-41.
2005: Tanimukai Hitoshi; Grundke-Iqbal Inge; Iqbal Khalid
Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease.
The American journal of pathology 2005;166(6):1761-71.
2005: Gong C-X; Liu F; Grundke-Iqbal I; Iqbal K
Post-translational modifications of tau protein in Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(6):813-38.
2005: Rahman Abdur; Grundke-Iqbal Inge; Iqbal Khalid
Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1.
Neurochemical research 2005;30(2):277-87.
2005: Iqbal Khalid; Grundke-Iqbal Inge
Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies.
Acta neuropathologica 2005;109(1):25-31.
2005: Tsujio Ichiro; Zaidi Tanweer; Xu Jiliu; Kotula Leszek; Grundke-Iqbal Inge; Iqbal Khalid
Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.
FEBS letters 2005;579(2):363-72.
2005: Sun Li; Wang XiaoChuang; Liu Shengyuan; Wang Quan; Wang JianZhi; Bennecib Malika; Gong Cheng-Xin; Sengupta Amitabha; Grundke-Iqbal Inge; Iqbal Khalid
Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat.
FEBS letters 2005;579(1):251-8.
2005: Iqbal Khalid; Alonso Alejandra del C; Chen She; Chohan M Omar; El-Akkad Ezzat; Gong Cheng-Xin; Khatoon Sabiha; Li Bin; Liu Fei; Rahman Abdur; Tanimukai Hitoshi; Grundke-Iqbal Inge
Tau pathology in Alzheimer disease and other tauopathies.
Biochimica et biophysica acta 2005;1739(2-3):198-210.
2005: Huang Yu; Liu Fei; Grundke-Iqbal Inge; Iqbal Khalid; Gong Cheng-Xin
NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain.
Neuroscience letters 2005;373(2):115-8.
2005: Liu Fei; Iqbal Khalid; Grundke-Iqbal Inge; Rossie Sandra; Gong Cheng-Xin
Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease.
The Journal of biological chemistry 2005;280(3):1790-6.
2004: Huang Yu; Tanimukai Hitoshi; Liu Fei; Iqbal Khalid; Grundke-Iqbal Inge; Gong Cheng-Xin
Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain.
The European journal of neuroscience 2004;20(12):3489-97.
2004: Liu Shi Jie; Zhang Jia Yu; Li Hong Lian; Fang Zheng Yu; Wang Qun; Deng Heng Mei; Gong Cheng Xin; Grundke-Iqbal Inge; Iqbal Khalid; Wang Jian Zhi
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain.
The Journal of biological chemistry 2004;279(48):50078-88.
2004: Haque Niloufar; Gong Cheng-Xin; Sengupta Amitabha; Iqbal Khalid; Grundke-Iqbal Inge
Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells.
Brain research. Molecular brain research 2004;129(1-2):163-70.
2004: Iqbal K; Grundke-Iqbal I
Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies.
Current drug targets 2004;5(6):495-502.
2004: Alonso Alejandra del C; Mederlyova Anna; Novak Michal; Grundke-Iqbal Inge; Iqbal Khalid
Promotion of hyperphosphorylation by frontotemporal dementia tau mutations.
The Journal of biological chemistry 2004;279(33):34873-81.
2004: Liu Fei; Iqbal Khalid; Grundke-Iqbal Inge; Hart Gerald W; Gong Cheng-Xin
O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(29):10804-9.
2004: Tanimukai Hitoshi; Grundke-Iqbal Inge; Iqbal Khalid
Inhibitors of protein phosphatase-2A: topography and subcellular localization.
Brain research. Molecular brain research 2004;126(2):146-56.
2004: Li Liang; Sengupta Amitabha; Haque Niloufar; Grundke-Iqbal Inge; Iqbal Khalid
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration.
FEBS letters 2004;566(1-3):261-9.
2004: Tatebayashi Yoshitaka; Haque Niloufar; Tung Yunn-Chyn; Iqbal Khalid; Grundke-Iqbal Inge
Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport.
Journal of cell science 2004;117(Pt 9):1653-63.
2004: Gong Cheng-Xin; Liu Fei; Wu Guoxin; Rossie Sandra; Wegiel Jerzy; Li Liang; Grundke-Iqbal Inge; Iqbal Khalid
Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5.
Journal of neurochemistry 2004;88(2):298-310.
2003: Pei Jin-Jing; Gong Cheng-Xin; An Wen-Lin; Winblad Bengt; Cowburn Richard F; Grundke-Iqbal Inge; Iqbal Khalid
Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.
The American journal of pathology 2003;163(3):845-58.
2003: Gong Cheng-Xin; Wang Jian-Zhi; Iqbal Khalid; Grundke-Iqbal Inge
Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices.
Neuroscience letters 2003;340(2):107-10.
2003: Pei Jin-Jing; Khatoon Sabiha; An Wen-Lin; Nordlinder Maria; Tanaka Toshihisa; Braak Heiko; Tsujio Ichiro; Takeda Masatoshi; Alafuzoff Irina; Winblad Bengt; Cowburn Richard F; Grundke-Iqbal Inge; Iqbal Khalid
Role of protein kinase B in Alzheimer's neurofibrillary pathology.
Acta neuropathologica 2003;105(4):381-92.
2003: Tatebayashi Yoshitaka; Lee Moon H; Li Liang; Iqbal Khalid; Grundke-Iqbal Inge
The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease.
Acta neuropathologica 2003;105(3):225-32.
2003: Hua Q; He R Q; Haque N; Qu M H; del Carmen Alonso A; Grundke-Iqbal I; Iqbal K
Microtubule associated protein tau binds to double-stranded but not single-stranded DNA.
Cellular and molecular life sciences : CMLS 2003;60(2):413-21.
2002: Pei Jin-Jing; Braak Heiko; An Wen-Lin; Winblad Bengt; Cowburn Richard F; Iqbal Khalid; Grundke-Iqbal Inge
Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease.
Brain research. Molecular brain research 2002;109(1-2):45-55.
2002: Liu Fei; Iqbal Khalid; Grundke-Iqbal Inge; Gong Cheng-Xin
Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta.
FEBS letters 2002;530(1-3):209-14.
2002: Pei Jin-Jing; Braak Heiko; Gong Cheng-Xin; Grundke-Iqbal Inge; Iqbal Khalid; Winblad Bengt; Cowburn Richard F
Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration.
Acta neuropathologica 2002;104(4):369-76.
2002: Iqbal Khalid; Alonso Alejandra del C; El-Akkad Ezzat; Gong Cheng-Xin; Haque Niloufar; Khatoon Sabiha; Pei Jin-Jing; Tsujio Ichiro; Wang Jian-Zhi; Grundke-Iqbal Inge
Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion.
Journal of molecular neuroscience : MN 2002;19(1-2):95-9.
2002: Iqbal Khalid; Grundke-Iqbal Inge
Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease.
Journal of Alzheimer's disease : JAD 2002;4(3):235-8.
2002: Hu Yuan Yuan; He Shan Shu; Wang Xiaochuan; Duan Qiu Hong; Grundke-Iqbal Inge; Iqbal Khalid; Wang Jianzhi
Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay.
The American journal of pathology 2002;160(4):1269-78.
2002: Wang Jianzhi; Wang Xiaochuan; Liu Rong; Wang Qun; Grundke-Iqbal Inge; Iqbal Khalid
In vitro analysis of tau phosphorylation sites and its biological activity.
Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences 2002;17(1):13-6.
2002: Hu Yuan-Yuan; He Shan-Shu; Wang Xiao-Chuang; Duan Qiu-Hong; Khatoon Sabiha; Iqbal Khalid; Grundke-Iqbal Inge; Wang Jian-Zhi
Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients.
Neuroscience letters 2002;320(3):156-60.
2002: Liu Fei; Zaidi Tanweer; Iqbal Khalid; Grundke-Iqbal Inge; Merkle Roberta K; Gong Cheng Xin
Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease.
FEBS letters 2002;512(1-3):101-6.
2002: Iqbal K; Alonso A del C; El-Akkad E; Gong C X; Haque N; Khatoon S; Tsujio I; Grundke-Iqbal I
Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration.
Journal of neural transmission. Supplementum 2002;(62):309-19.
2002: Liu F; Zaidi T; Iqbal K; Grundke-Iqbal I; Gong C-X
Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.
Neuroscience 2002;115(3):829-37.
2001: Vijayan S; El-Akkad E; Grundke-Iqbal I; Iqbal K
A pool of beta-tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain.
FEBS letters 2001;509(3):375-81.
2001: Wang J; Tung Y C; Wang Y; Li X T; Iqbal K; Grundke-Iqbal I
Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells.
FEBS letters 2001;507(1):81-7.
2001: Alonso A D; Zaidi T; Novak M; Barra H S; Grundke-Iqbal I; Iqbal K
Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein.
The Journal of biological chemistry 2001;276(41):37967-73.
2001: Alonso A; Zaidi T; Novak M; Grundke-Iqbal I; Iqbal K
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6923-8.
2001: Sato Y; Naito Y; Grundke-Iqbal I; Iqbal K; Endo T
Analysis of N-glycans of pathological tau: possible occurrence of aberrant processing of tau in Alzheimer's disease.
FEBS letters 2001;496(2-3):152-60.
2001: Cheng L Y; Wang J Z; Gong C X; Pei J J; Zaidi T; Grundke-Iqbal I; Iqbal K
Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue nonbinding phosphatase activities.
Neurochemical research 2001;26(4):425-38.
2001: Gong C X; Lidsky T; Wegiel J; Grundke-Iqbal I; Iqbal K
Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain.
Brain research. Brain research protocols 2001;6(3):134-40.
2001: Bennecib M; Gong C X; Grundke-Iqbal I; Iqbal K
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
FEBS letters 2001;490(1-2):15-22.
2000: Iqbal K; Grundke-Iqbal I
Alzheimer disease is multifactorial and heterogeneous.
Neurobiology of aging 2000;21(6):901-2; discussion 903-4.
2000: Bennecib M; Gong C X; Grundke-Iqbal I; Iqbal K
Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.
FEBS letters 2000;485(1):87-93.
2000: Wang J; Wei Z; Wang Q; Grundke-Iqbal I; Iqbal K
[Association of microtubule promoting and binding activity of tau with its phosphorylation sites]
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2000;22(2):120-3.
2000: Tsujio I; Tanaka T; Kudo T; Nishikawa T; Shinozaki K; Grundke-Iqbal I; Iqbal K; Takeda M
Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation.
FEBS letters 2000;469(1):111-7.
2000: Gong C X; Lidsky T; Wegiel J; Zuck L; Grundke-Iqbal I; Iqbal K
Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.
The Journal of biological chemistry 2000;275(8):5535-44.
2000: Cheng L Y; Wang J Z; Gong C X; Pei J J; Zaidi T; Grundke-Iqbal I; Iqbal K
Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue binding phosphatases.
Neurochemical research 2000;25(1):107-20.
2000: Gong C X; Wegiel J; Lidsky T; Zuck L; Avila J; Wisniewski H M; Grundke-Iqbal I; Iqbal K
Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.
Brain research 2000;853(2):299-309.
2000: Iqbal K; Alonso A D; Gondal J A; Gong C X; Haque N; Khatoon S; Sengupta A; Wang J Z; Grundke-Iqbal I
Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach.
Journal of neural transmission. Supplementum 2000;59():213-22.
1999: Grundke-Iqbal I; Iqbal K
Tau pathology generated by overexpression of tau.
The American journal of pathology 1999;155(6):1781-5.
1999: Pei J J; Braak E; Braak H; Grundke-Iqbal I; Iqbal K; Winblad B; Cowburn R F
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.
Journal of neuropathology and experimental neurology 1999;58(9):1010-9.
1999: Haque N; Tanaka T; Iqbal K; Grundke-Iqbal I
Regulation of expression, phosphorylation and biological activity of tau during differentiation in SY5Y cells.
Brain research 1999;838(1-2):69-77.
1999: Tatebayashi Y; Iqbal K; Grundke-Iqbal I
Dynamic regulation of expression and phosphorylation of tau by fibroblast growth factor-2 in neural progenitor cells from adult rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(13):5245-54.
1999: Zhong J; Iqbal K; Grundke-Iqbal I
Hyperphosphorylated tau in SY5Y cells: similarities and dissimilarities to abnormally hyperphosphorylated tau from Alzheimer disease brain.
FEBS letters 1999;453(1-2):224-8.
1998: Sironi J J; Yen S H; Gondal J A; Wu Q; Grundke-Iqbal I; Iqbal K
Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK.
FEBS letters 1998;436(3):471-5.
1998: Wang J Z; Wu Q; Smith A; Grundke-Iqbal I; Iqbal K
Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase.
FEBS letters 1998;436(1):28-34.
1998: Sengupta A; Kabat J; Novak M; Wu Q; Grundke-Iqbal I; Iqbal K
Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.
Archives of biochemistry and biophysics 1998;357(2):299-309.
1998: Ikura Y; Kudo T; Tanaka T; Tanii H; Grundke-Iqbal I; Iqbal K; Takeda M
Levels of tau phosphorylation at different sites in Alzheimer disease brain.
Neuroreport 1998;9(10):2375-9.
1998: Pei J J; Grundke-Iqbal I; Iqbal K; Bogdanovic N; Winblad B; Cowburn R F
Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.
Brain research 1998;797(2):267-77.
1998: Tanaka T; Zhong J; Iqbal K; Trenkner E; Grundke-Iqbal I
The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases.
FEBS letters 1998;426(2):248-54.
1998: Iqbal K; Grundke-Iqbal I
Tau phosphatase activity as a therapeutic target for AD.
Drug news & perspectives 1998;11(1):10-4.
1998: Iqbal K; Alonso A C; Gong C X; Khatoon S; Pei J J; Wang J Z; Grundke-Iqbal I
Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles.
Journal of neural transmission. Supplementum 1998;53():169-80.
1998: Pei J J; Gong C X; Iqbal K; Grundke-Iqbal I; Wu Q L; Winblad B; Cowburn R F
Subcellular distribution of protein phosphatases and abnormally phosphorylated tau in the temporal cortex from Alzheimer's disease and control brains.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(1):69-83.
1997: Ruben G C; Ciardelli T L; Grundke-Iqbal I; Iqbal K
Alzheimer disease hyperphosphorylated tau aggregates hydrophobically.
Synapse (New York, N.Y.) 1997;27(3):208-29.
1997: Iqbal K; Grundke-Iqbal I
Mechanism of Alzheimer neurofibrillary degeneration and the formation of tangles.
Molecular psychiatry 1997;2(3):178-80.
1997: Singh T J; Grundke-Iqbal I; Wu W Q; Chauhan V; Novak M; Kontzekova E; Iqbal K
Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates.
Molecular and cellular biochemistry 1997;168(1-2):141-8.
1997: Sengupta A; Wu Q; Grundke-Iqbal I; Iqbal K; Singh T J
Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5.
Molecular and cellular biochemistry 1997;167(1-2):99-105.
1997: Alonso A D; Grundke-Iqbal I; Barra H S; Iqbal K
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):298-303.
1997: Pei J J; Tanaka T; Tung Y C; Braak E; Iqbal K; Grundke-Iqbal I
Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.
Journal of neuropathology and experimental neurology 1997;56(1):70-8.
1997: Pei J J; Grundke-Iqbal I; Iqbal K; Bogdanovic N; Winblad B; Cowburn R F
Elevated protein levels of protein phosphatases PP-2A and PP-2B in astrocytes of Alzheimer's disease temporal cortex.
Journal of neural transmission (Vienna, Austria : 1996) 1997;104(11-12):1329-38.
1997: Iqbal K; Grundke-Iqbal I
Elevated levels of tau and ubiquitin in brain and cerebrospinal fluid in Alzheimer's disease.
International psychogeriatrics / IPA 1997;9 Suppl 1():289-96; discussion 317-21.
1996: Gong C X; Shaikh S; Grundke-Iqbal I; Iqbal K
Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics.
Brain research 1996;741(1-2):95-102.
1996: Wang J Z; Grundke-Iqbal I; Iqbal K
Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease.
Nature medicine 1996;2(8):871-5.
1996: Alonso A C; Grundke-Iqbal I; Iqbal K
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.
Nature medicine 1996;2(7):783-7.
1996: Wang J Z; Grundke-Iqbal I; Iqbal K
Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.
Brain research. Molecular brain research 1996;38(2):200-8.
1996: Singh T J; Wang J Z; Novak M; Kontzekova E; Grundke-Iqbal I; Iqbal K
Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules.
FEBS letters 1996;387(2-3):145-8.
1996: Singh T J; Grundke-Iqbal I; Iqbal K
Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases.
Archives of biochemistry and biophysics 1996;328(1):43-50.
1996: Singh T J; Zaidi T; Grundke-Iqbal I; Iqbal K
Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain.
Molecular and cellular biochemistry 1996;154(2):143-51.
1996: Iqbal K; Grundke-Iqbal I
Molecular mechanism of Alzheimer's neurofibrillary degeneration and therapeutic intervention.
Annals of the New York Academy of Sciences 1996;777():132-8.
1995: Gong C X; Shaikh S; Wang J Z; Zaidi T; Grundke-Iqbal I; Iqbal K
Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.
Journal of neurochemistry 1995;65(2):732-8.
1995: Alonso A del C; Grundke-Iqbal I; Iqbal K
Bovine and human tau, highly homologous but less crossreactive: implications for Alzheimer disease.
Brain research. Molecular brain research 1995;31(1-2):194-200.
1995: Wang J Z; Gong C X; Zaidi T; Grundke-Iqbal I; Iqbal K
Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.
The Journal of biological chemistry 1995;270(9):4854-60.
1995: Singh T J; Grundke-Iqbal I; Iqbal K
Phosphorylation of tau protein by casein kinase-1 converts it to an abnormal Alzheimer-like state.
Journal of neurochemistry 1995;64(3):1420-3.
1995: Haque N; Denman R B; Merz G; Grundke-Iqbal I; Iqbal K
Phosphorylation and accumulation of tau without any concomitant increase in tubulin levels in Chinese hamster ovary cells stably transfected with human tau441.
FEBS letters 1995;360(2):132-6.
1995: Tanaka T; Iqbal K; Trenkner E; Liu D J; Grundke-Iqbal I
Abnormally phosphorylated tau in SY5Y human neuroblastoma cells.
FEBS letters 1995;360(1):5-9.
1995: Khatoon S; Grundke-Iqbal I; Iqbal K
Guanosine triphosphate binding to beta-subunit of tubulin in Alzheimer's disease brain: role of microtubule-associated protein tau.
Journal of neurochemistry 1995;64(2):777-87.
1995: Singh T J; Zaidi T; Grundke-Iqbal I; Iqbal K
Modulation of GSK-3-catalyzed phosphorylation of microtubule-associated protein tau by non-proline-dependent protein kinases.
FEBS letters 1995;358(1):4-8.
1995: Singh T J; Haque N; Grundke-Iqbal I; Iqbal K
Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3.
FEBS letters 1995;358(3):267-72.
1994: Khatoon S; Grundke-Iqbal I; Iqbal K
Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains.
FEBS letters 1994;351(1):80-4.
1994: Iqbal K; Alonso A C; Gong C X; Khatoon S; Singh T J; Grundke-Iqbal I
Mechanism of neurofibrillary degeneration in Alzheimer's disease.
Molecular neurobiology 1994;9(1-3):119-23.
1994: Gong C X; Grundke-Iqbal I; Iqbal K
Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.
Neuroscience 1994;61(4):765-72.
1994: Pei J J; Sersen E; Iqbal K; Grundke-Iqbal I
Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.
Brain research 1994;655(1-2):70-6.
1994: Iqbal K; Zaidi T; Bancher C; Grundke-Iqbal I
Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation.
FEBS letters 1994;349(1):104-8.
1994: Kudo T; Iqbal K; Ravid R; Swaab D F; Grundke-Iqbal I
Ubiquitin in cerebrospinal fluid: a rapid competitive enzyme-linked immunoflow assay.
Neuroreport 1994;5(12):1522-4.
1994: Alonso A C; Zaidi T; Grundke-Iqbal I; Iqbal K
Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5562-6.
1994: Kudo T; Iqbal K; Ravid R; Swaab D F; Grundke-Iqbal I
Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels.
Brain research 1994;639(1):1-7.
1994: Gong C X; Grundke-Iqbal I; Damuni Z; Iqbal K
Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease.
FEBS letters 1994;341(1):94-8.
1994: Gong C X; Singh T J; Grundke-Iqbal I; Iqbal K
Alzheimer's disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase-2B (calcineurin).
Journal of neurochemistry 1994;62(2):803-6.
1994: Singh T J; Grundke-Iqbal I; McDonald B; Iqbal K
Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases.
Molecular and cellular biochemistry 1994;131(2):181-9.
1994: Rehman A; Tung Y C; Iqbal K; Grundke-Iqbal I
Rabbit IgG cross-reacts with Alzheimer neurofibrillary tangles.
Acta neuropathologica 1994;87(5):443-9.
1993: Köpke E; Tung Y C; Shaikh S; Alonso A C; Iqbal K; Grundke-Iqbal I
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.
The Journal of biological chemistry 1993;268(32):24374-84.
1993: Gong C X; Singh T J; Grundke-Iqbal I; Iqbal K
Phosphoprotein phosphatase activities in Alzheimer disease brain.
Journal of neurochemistry 1993;61(3):921-7.
1993: Ruben G C; Iqbal K; Wisniewski H M; Johnson J E; Grundke-Iqbal I
Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein tau: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid.
Brain research 1993;602(2):164-79.
1993: Ruben G C; Iqbal K; Grundke-Iqbal I; Johnson J E
The organization of the microtubule associated protein tau in Alzheimer paired helical filaments.
Brain research 1993;602(1):1-13.
1993: Iqbal K; Alonso A; Gong C; Khatoon S; Kudo T; Singh T; Grundke-Iqbal I
Molecular pathology of Alzheimer neurofibrillary degeneration.
Acta neurobiologiae experimentalis 1993;53(1):325-35.
1992: Swaab D F; Grundke-Iqbal I; Iqbal K; Kremer H P; Ravid R; van de Nes J A
Tau and ubiquitin in the human hypothalamus in aging and Alzheimer's disease.
Brain research 1992;590(1-2):239-49.
1992: Khatoon S; Grundke-Iqbal I; Iqbal K
Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein.
Journal of neurochemistry 1992;59(2):750-3.
1992: Wrzolek M A; Merz P A; Kascsak R; Grundke-Iqbal I; Iqbal K; Rubenstein R; Tonna-DeMasi M; Goller N L; Mehta P; Wisniewski H M
Immune electron microscopic characterization of monoclonal antibodies to Alzheimer neurofibrillary tangles.
The American journal of pathology 1992;141(2):343-55.
1992: Lin F H; Lin R; Wisniewski H M; Hwang Y W; Grundke-Iqbal I; Healy-Louie G; Iqbal K
Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains.
Biochemical and biophysical research communications 1992;182(1):238-46.
1991: Wang G P; Khatoon S; Iqbal K; Grundke-Iqbal I
Brain ubiquitin is markedly elevated in Alzheimer disease.
Brain research 1991;566(1-2):146-51.
1991: Ruben G C; Iqbal K; Grundke-Iqbal I; Wisniewski H M; Ciardelli T L; Johnson J E
The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer.
The Journal of biological chemistry 1991;266(32):22019-27.
1991: Iqbal K; Braak E; Braak H; Zaidi T; Grundke-Iqbal I
A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Neurobiology of aging 1991;12(4):357-61.
1991: Bancher C; Grundke-Iqbal I; Iqbal K; Fried V A; Smith H T; Wisniewski H M
Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease.
Brain research 1991;539(1):11-8.
1991: Iqbal K; Grundke-Iqbal I
Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease.
Molecular neurobiology 1991;5(2-4):399-410.
1991: Wang G P; Iqbal K; Bucht G; Winblad B; Wisniewski H M; Grundke-Iqbal I
Alzheimer's disease: paired helical filament immunoreactivity in cerebrospinal fluid.
Acta neuropathologica 1991;82(1):6-12.
1990: Grundke-Iqbal I; Fleming J; Tung Y C; Lassmann H; Iqbal K; Joshi J G
Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.
Acta neuropathologica 1990;81(2):105-10.
1990: Jellinger K; Paulus W; Grundke-Iqbal I; Riederer P; Youdim M B
Brain iron and ferritin in Parkinson's and Alzheimer's diseases.
Journal of neural transmission. Parkinson's disease and dementia section 1990;2(4):327-40.
1989: Iqbal K; Grundke-Iqbal I; Smith A J; George L; Tung Y C; Zaidi T
Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5646-50.
1989: Iqbal K; Smith A J; Zaidi T; Grundke-Iqbal I
Microtubule-associated protein tau. Identification of a novel peptide from bovine brain.
FEBS letters 1989;248(1-2):87-91.
1989: Perry G; Mulvihill P; Fried V A; Smith H T; Grundke-Iqbal I; Iqbal K
Immunochemical properties of ubiquitin conjugates in the paired helical filaments of Alzheimer disease.
Journal of neurochemistry 1989;52(5):1523-8.
1989: Grundke-Iqbal I; Iqbal K; George L; Tung Y C; Kim K S; Wisniewski H M
Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2853-7.
1989: Bancher C; Grundke-Iqbal I; Iqbal K; Kim K S; Wisniewski H M
Immunoreactivity of neuronal lipofuscin with monoclonal antibodies to the amyloid beta-protein.
Neurobiology of aging 1989;10(2):125-32.
1989: Shankar S K; Yanagihara R; Garruto R M; Grundke-Iqbal I; Kosik K S; Gajdusek D C
Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam.
Annals of neurology 1989;25(2):146-51.
1989: Bancher C; Brunner C; Lassmann H; Budka H; Jellinger K; Wiche G; Seitelberger F; Grundke-Iqbal I; Iqbal K; Wisniewski H M
Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease.
Brain research 1989;477(1-2):90-9.
1989: Bancher C; Lassmann H; Budka H; Jellinger K; Grundke-Iqbal I; Iqbal K; Wiche G; Seitelberger F; Wisniewski H M
An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination.
Journal of neuropathology and experimental neurology 1989;48(1):81-93.
1989: Bancher C; Grundke-Iqbal I; Iqbal K; Kim K S; Wisniewski H M
A 31 kilodalton beta-protein immunoreactive polypeptide in neuronal lipofuscin.
Progress in clinical and biological research 1989;317():913-24.
1989: Grundke-Iqbal I; Iqbal K
Neuronal cytoskeleton in the biology of Alzheimer disease.
Progress in clinical and biological research 1989;317():745-53.
1989: Iqbal K; Wang G P; Grundke-Iqbal I; Wisniewski H M
Laboratory diagnostic tests for Alzheimer's disease.
Progress in clinical and biological research 1989;317():679-87.
1989: Barcikowska M; Wisniewski H M; Bancher C; Grundke-Iqbal I
About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation.
Acta neuropathologica 1989;78(3):225-31.
1989: Bancher C; Brunner C; Lassmann H; Budka H; Jellinger K; Seitelberger F; Grundke-Iqbal I; Iqbal K; Wisniewski H M
Tau and ubiquitin immunoreactivity at different stages of formation of Alzheimer neurofibrillary tangles.
Progress in clinical and biological research 1989;317():837-48.
1988: Galloway P G; Grundke-Iqbal I; Iqbal K; Perry G
Lewy bodies contain epitopes both shared and distinct from Alzheimer neurofibrillary tangles.
Journal of neuropathology and experimental neurology 1988;47(6):654-63.
1988: Grundke-Iqbal I; Vorbrodt A W; Iqbal K; Tung Y C; Wang G P; Wisniewski H M
Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments.
Brain research 1988;464(1):43-52.
1987: Iqbal K; Grundke-Iqbal I; Merz P A; Wisniewski H M; Zaidi T
In vitro assembly and isolation of neurofilaments and microtubules from mammalian CNS.
Brain research 1987;388(2):163-72.
1987: Wisniewski H M; Iqbal K; Grundke-Iqbal I; Rubenstein R
The solubility controversy of paired helical filaments: a commentary.
Neurochemical research 1987;12(1):93-5.
1987: Iqbal K; Grundke-Iqbal I; Wisniewski H M
Alzheimer's disease, microtubule and neurofilament proteins, and axoplasmic flow.
Lancet 1987;1(8524):102.
1987: Popovitch E R; Wisniewski H M; Kaufman M A; Grundke-Iqbal I; Wen G Y
Young adult-form of dementia with neurofibrillary changes and Lewy bodies.
Acta neuropathologica 1987;74(1):97-104.
1987: Alafuzoff I; Adolfsson R; Grundke-Iqbal I; Winblad B
Blood-brain barrier in Alzheimer dementia and in non-demented elderly. An immunocytochemical study.
Acta neuropathologica 1987;73(2):160-6.
1987: Bancher C; Lassmann H; Budka H; Grundke-Iqbal I; Iqbal K; Wiche G; Seitelberger F; Wisniewski H M
Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.
Acta neuropathologica 1987;74(1):39-46.
1986: Iqbal K; Grundke-Iqbal I; Zaidi T; Merz P A; Wen G Y; Shaikh S S; Wisniewski H M; Alafuzoff I; Winblad B
Defective brain microtubule assembly in Alzheimer's disease.
Lancet 1986;2(8504):421-6.
1986: Grundke-Iqbal I; Iqbal K; Tung Y C; Quinlan M; Wisniewski H M; Binder L I
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(13):4913-7.
1986: Iqbal K; Grundke-Iqbal I; Zaidi T; Ali N; Wisniewski H M
Are Alzheimer neurofibrillary tangles insoluble polymers?
Life sciences 1986;38(18):1695-700.
1986: Grundke-Iqbal I; Iqbal K; Quinlan M; Tung Y C; Zaidi M S; Wisniewski H M
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
The Journal of biological chemistry 1986;261(13):6084-9.
1986: Braak H; Braak E; Grundke-Iqbal I; Iqbal K
Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques.
Neuroscience letters 1986;65(3):351-5.
1986: Iqbal K; Grundke-Iqbal I; Wisniewski H M
Neuronal cytoskeleton in aging and dementia.
Progress in brain research 1986;70():279-88.
1985: Mehta P D; Thal L; Wisniewski H M; Grundke-Iqbal I; Iqbal K
Paired helical filament antigen in CSF.
Lancet 1985;2(8445):35.
1985: Alafuzoff I; Adolfsson R; Grundke-Iqbal I; Winblad B
Perivascular deposits of serum proteins in cerebral cortex in vascular dementia.
Acta neuropathologica 1985;66(4):292-98.
1985: Grundke-Iqbal I; Iqbal K; Tung Y C; Wang G P; Wisniewski H M
Alzheimer paired helical filaments: cross-reacting polypeptide/s normally present in brain.
Acta neuropathologica 1985;66(1):52-61.
1985: Grundke-Iqbal I; Wang G P; Iqbal K; Tung Y C; Wisniewski H M
Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies.
Acta neuropathologica 1985;68(4):279-83.
1984: Wang G P; Grundke-Iqbal I; Kascsak R J; Iqbal K; Wisniewski H M
Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigen(s).
Acta neuropathologica 1984;62(4):268-75.
1984: Grundke-Iqbal I; Iqbal K; Tung Y C; Wisniewski H M
Alzheimer paired helical filaments: immunochemical identification of polypeptides.
Acta neuropathologica 1984;62(4):259-67.
1982: Iqbal K; Grundke-Iqbal I; Merz P A; Wisniewski H M
Alzheimer Neurofibrillary tangle: morphology and biochemistry.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1982;Suppl 5():10-4.
1982: Wisniewski H M; Vorbrodt A W; Moretz R C; Lossinsky A S; Grundke-Iqbal I
Pathogenesis of neuritic (senile) and amyloid plaque formation.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1982;Suppl 5():3-9.
1982: Grundke-Iqbal I; Iqbal K; Wisniewski H M
Immunocytochemical studies on neurofibrillary changes.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1982;Suppl 5():20-5.
1981: Grundke-Iqbal I; Raine C S; Johnson A B; Brosnan C F; Bornstein M B
Experimental allergic encephalomyelitis. Characterization of serum factors causing demyelination and swelling of myelin.
Journal of the neurological sciences 1981;50(1):63-79.
1980: Grundke-Iqbal I; Lassmann H; Wisniewski H M
Chronic relapsing experimental allergic encephalomyelitis. Immunohistochemical studies.
Archives of neurology 1980;37(10):651-6.
1980: Grundke-Iqbal I; Bornstein M B
Multiple sclerosis: serum gamma globulin and demyelination in organ culture.
Neurology 1980;30(7 Pt 1):749-54.
1979: Grundke-Iqbal I; Johnson A B; Terry R D; Wisniewski H M; Iqbal K
Alzheimer neurofibrillary tangles: antiserum and immunohistological staining.
Annals of neurology 1979;6(6):532-7.
1979: Grundke-Iqbal I; Johnson A B; Wisniewski H M; Terry R D; Iqbal K
Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.
Lancet 1979;1(8116):578-80.
1979: Grundke-Iqbal I; Bornstein M B
Multiple sclerosis: immunochemical studies on the demyelinating serum factor.
Brain research 1979;160(3):489-503.
1978: Iqbal K; Grundke-Iqbal I; Wisniewski H M; Terry R D
Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules.
Brain research 1978;142(2):321-32.
1977: Iqbal K; Grundke-Iqbal I; Wisniewski H M; Terry R D
On neurofilament and neurotubule proteins from human autopsy tissue.
Journal of neurochemistry 1977;29(3):417-24.
1977: Iqbal K; Grundke-Iqbal I; Wisniewski H M
Oligodendroglia from human autopsied brain: bulk isolation and some chemical properties.
Journal of neurochemistry 1977;28(4):707-16.
1975: Iqbal K; Wisniewski H M; Grundke-Iqbal I; Korthals J K; Terry R D
Chemical pathology of neurofibrils. Neurofibrillary tangles of Alzheimer's presenile-senile dementia.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1975;23(7):563-9.
1974: Iqbal K; Tellez-Nagel I; Grundke-Iqbal I
Protein abnormalities in Huntington's chorea.
Brain research 1974;76(1):178-84.
1974: Vitetta E S; Grundke-Iqbal I; Holmes K V; Uhr J W
Cell surface immunoglobulin. VII. Synthesis, shedding, and secretion of immunoglobulin by lymphoid cells of germ-free mice.
The Journal of experimental medicine 1974;139(4):862-76.
1974: Grundke-Iqbal I; Uhr J W
Cell surface immunoglobulin. VI. Dynamics on a human lymphoma line.
European journal of immunology 1974;4(3):159-63.
1972: Sherr C J; Baur S; Grundke I; Zeligs J; Zeligs B; Uhr J W
Cell surface immunoglobulin. 3. Isolation and characterization of immunoglobulin from nonsecretory human lymphoid cells.
The Journal of experimental medicine 1972;135(6):1392-405.

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Inge Grundke-Iqbal

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