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Jochen Klein
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Living Beings
Chemicals & Drugs
Anatomy
Procedures
Physiology
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Network (preview)
25
Löffelholz, Konrad
9
Weichel, Oksana
9
Kiewert, Cornelia
8
Hilgert, Michael
7
Hartmann, Joachim
6
Buchholzer, Marie-Luise
6
Chatterjee, Shyam
6
Oesch, Franz
5
Platt, Karl
5
Erb, C
5
Kumar, Vikas
4
Kötter, K
4
Mdzinarishvili, Alexander
4
Valeva, Angela
4
Van Der Schyf, Cornelis
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All Publications
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2009: Naik Runa S; Hartmann Joachim; Kiewert Cornelia; Duysen Ellen G; Lockridge Oksana; Klein Jochen
Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2009;12(1):79-85.
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2008: Krüger Phillip; Daneshfar Rambod; Eckert Gunter P; Klein Jochen; Volmer Dietrich A; Bahr Ute; Müller Walter E; Karas Michael; Schubert-Zsilavecz Manfred; Abdel-Tawab Mona
Metabolism of boswellic acids in vitro and in vivo.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):1135-42.
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2008: Hartmann Joachim; Kiewert Cornelia; Duysen Ellen G; Lockridge Oksana; Klein Jochen
Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice.
Neurochemistry international 2008;52(6):972-8.
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2008: Kiewert Cornelia; Kumar Vikas; Hildmann Oksana; Hartmann Joachim; Hillert Markus; Klein Jochen
Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide.
Brain research 2008;1201():143-50.
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2008: Hao Jiukuan; Mdzinarishvili Alexander; Abbruscato Thomas J; Klein Jochen; Geldenhuys Werner J; Van der Schyf Cornelis J; Bickel Ulrich
Neuroprotection in mice by NGP1-01 after transient focal brain ischemia.
Brain research 2008;1196():113-20.
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2007: Klein Jochen
Phenserine.
Expert opinion on investigational drugs 2007;16(7):1087-97.
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2007: Hartmann Joachim; Kiewert Cornelia; Duysen Ellen G; Lockridge Oksana; Greig Nigel H; Klein Jochen
Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity.
Journal of neurochemistry 2007;100(5):1421-9.
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2007: Kiewert Cornelia; Kumar Vikas; Hildmann Oksana; Rueda Misty; Hartmann Joachim; Naik Runa S; Klein Jochen
Role of GABAergic antagonism in the neuroprotective effects of bilobalide.
Brain research 2007;1128(1):70-8.
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2007: Mdzinarishvili A; Kiewert C; Kumar V; Hillert M; Klein J
Bilobalide prevents ischemia-induced edema formation in vitro and in vivo.
Neuroscience 2007;144(1):217-22.
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2006: Kumar Vikas; Naik Runa S; Hillert Markus; Klein Jochen
Effects of chloride flux modulators in an in vitro model of brain edema formation.
Brain research 2006;1122(1):222-9.
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2006: Kumar Vikas; Mdzinarishvili Alexander; Kiewert Cornelia; Abbruscato Thomas; Bickel Ulrich; van der Schyf Cornelis J; Klein Jochen
NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort.
Journal of pharmacological sciences 2006;102(1):47-54.
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2006: Kiewert Cornelia; Hartmann Joachim; Stoll James; Thekkumkara Thomas J; Van der Schyf Cornelis J; Klein Jochen
NGP1-01 is a brain-permeable dual blocker of neuronal voltage- and ligand-operated calcium channels.
Neurochemical research 2006;31(3):395-9.
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2005: Klein Jochen
Functions and pathophysiological roles of phospholipase D in the brain.
Journal of neurochemistry 2005;94(6):1473-87.
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2005: Mdzinarishvili Alexander; Geldenhuys Werner J; Abbruscato Thomas J; Bickel Ulrich; Klein Jochen; Van der Schyf Cornelis J
NGP1-01, a lipophilic polycyclic cage amine, is neuroprotective in focal ischemia.
Neuroscience letters 2005;383(1-2):49-53.
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2005: Ahsan Fakhrul; Klein Jochen
Microarray analysis and response of the lungs to inhaled insulin.
Diabetes technology & therapeutics 2005;7(3):525-7.
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2005: Schatter Beate; Jin Shenchu; Löffelholz Konrad; Klein Jochen
Cross-talk between phosphatidic acid and ceramide during ethanol-induced apoptosis in astrocytes.
BMC pharmacology 2005;5():3.
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2004: Walter Anna; Korth Ulrike; Hilgert Michael; Hartmann Joachim; Weichel Oksana; Hilgert Marion; Fassbender Klaus; Schmitt Andrea; Klein Jochen
Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients.
Neurobiology of aging 2004;25(10):1299-303.
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2004: Weismüller Tobias; Klein Jochen; Löffelholz Konrad
Effects of norepinephrine and cardiotrophin-1 on phospholipase D activity and incorporation of myristic acid into phosphatidylcholine in rat heart.
Journal of pharmacological sciences 2004;95(3):335-40.
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2004: Kiewert Cornelia; Buchholzer Marie-Luise; Hartmann Joachim; Chatterjee Shyam Sunder; Klein Jochen
Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John's Wort.
Neuroscience letters 2004;364(3):195-8.
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2004: Hartmann J; Erb C; Ebert U; Baumann K H; Popp A; König G; Klein J
Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice.
Neuroscience 2004;125(4):1009-17.
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2003: Schatter Beate; Walev Ivan; Klein Jochen
Mitogenic effects of phospholipase D and phosphatidic acid in transiently permeabilized astrocytes: effects of ethanol.
Journal of neurochemistry 2003;87(1):95-100.
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2003: Korth Ulrike; Krieter Heiner; Denz Christof; Janke Christoph; Ellinger Klaus; Bertsch Thomas; Henn Claudia; Klein Jochen
Intestinal ischaemia during cardiac arrest and resuscitation: comparative analysis of extracellular metabolites by microdialysis.
Resuscitation 2003;58(2):209-17.
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2003: Klein J; Weichel O; Hilgert M; Rupp J; Chatterjee S S; Nawrath H
Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes.
Pharmacopsychiatry 2003;36 Suppl 1():S78-83.
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2003: Buchholzer Marie-Luise; Klein Jochen
Nitrergic modulation of hippocampal acetylcholine release is independent of endothelial NO synthase activity.
Neurochemical research 2003;28(3-4):587-91.
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2003: Hilgert Michael; Hartmann Joachim; Löffelholz Konrad; Jeltsch Hélène; Cassel Jean-Christophe; Klein Jochen
Effects of septal grafts on acetylcholine release from rat hippocampus after 192 IgG-saporin lesion.
Neurochemical research 2003;28(3-4):467-72.
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2003: Koch Thomas; Brandenburg Lars-Ove; Schulz Stefan; Liang Yingjian; Klein Jochen; Hollt Volker
ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.
The Journal of biological chemistry 2003;278(11):9979-85.
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2002: Buchholzer Marie-Luise; Klein Jochen
NMDA-induced acetylcholine release in mouse striatum: role of NO synthase isoforms.
Journal of neurochemistry 2002;82(6):1558-60.
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2002: Jin Shenchu; Schatter Beate; Weichel Oksana; Walev Ivan; Ryu SungHo; Klein Jochen
Stability of phospholipase D in primary astrocytes.
Biochemical and biophysical research communications 2002;297(3):545-51.
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2002: Göpel Christoph; Schmidt Martin H; Campanini Marianne; Klein Jochen
Breakdown of choline-containing phospholipids in rat brain during severe weight loss.
Neuroscience letters 2002;326(1):21-4.
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2002: Buchholzer Marie-Luise; Dvorak Claudia; Chatterjee Shyam S; Klein Jochen
Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort.
The Journal of pharmacology and experimental therapeutics 2002;301(2):714-9.
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2002: Klein Jochen; Weichel Oksana; Ruhr Judith; Dvorak Claudia; Löffelholz Konrad
A homeostatic mechanism counteracting K(+) -evoked choline release in adult brain.
Journal of neurochemistry 2002;80(5):843-9.
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2001: Erb C; Troost J; Kopf S; Schmitt U; Löffelholz K; Soreq H; Klein J
Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase.
Journal of neurochemistry 2001;77(2):638-46.
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2001: Kopf S R; Buchholzer M L; Hilgert M; Löffelholz K; Klein J
Glucose plus choline improve passive avoidance behaviour and increase hippocampal acetylcholine release in mice.
Neuroscience 2001;103(2):365-71.
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2000: Kötter K; Jin S; Klein J
Inhibition of astroglial cell proliferation by alcohols: interference with the protein kinase C-phospholipase D signaling pathway.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2000;18(8):825-31.
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2000: Korth U; Merkel G; Fernandez F F; Jandewerth O; Dogan G; Koch T; van Ackern K; Weichel O; Klein J
Tourniquet-induced changes of energy metabolism in human skeletal muscle monitored by microdialysis.
Anesthesiology 2000;93(6):1407-12.
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2000: Hilgert M; Buchholzer M; Jeltsch H; Kelche C; Cassel J C; Klein J
Serotonergic modulation of hippocampal acetylcholine release after long-term neuronal grafting.
Neuroreport 2000;11(14):3063-5.
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2000: Kötter K; Ji a S; von Eichel-Streiber C; Park J B; Ryu S H; Klein J
Activation of astroglial phospholipase D activity by phorbol ester involves ARF and Rho proteins.
Biochimica et biophysica acta 2000;1485(2-3):153-62.
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2000: Walev I; Klein J; Husmann M; Valeva A; Strauch S; Wirtz H; Weichel O; Bhakdi S
Potassium regulates IL-1 beta processing via calcium-independent phospholipase A2.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5120-4.
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2000: Valeva A; Walev I; Gerber A; Klein J; Palmer M; Bhakdi S
Staphylococcal alpha-toxin: repair of a calcium-impermeable pore in the target cell membrane.
Molecular microbiology 2000;36(2):467-76.
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2000: Klein J
Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids.
Journal of neural transmission (Vienna, Austria : 1996) 2000;107(8-9):1027-63.
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1999: Weichel O; Hilgert M; Chatterjee S S; Lehr M; Klein J
Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus.
Naunyn-Schmiedeberg's archives of pharmacology 1999;360(6):609-15.
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1999: Waring M; Drappatz J; Weichel O; Seimetz P; Sarri E; Böckmann I; Kempter U; Valeva A; Klein J
Modulation of neuronal phospholipase D activity under depolarizing conditions.
FEBS letters 1999;464(1-2):21-4.
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1999: Kötter K; Klein J
Ethanol inhibits astroglial cell proliferation by disruption of phospholipase D-mediated signaling.
Journal of neurochemistry 1999;73(6):2517-23.
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1999: Kötter K; Klein J
Adrenergic modulation of astroglial phospholipase D activity and cell proliferation.
Brain research 1999;830(1):138-45.
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1999: Hilgert M; Nöldner M; Chatterjee S S; Klein J
KA-672 inhibits rat brain acetylcholinesterase in vitro but not in vivo.
Neuroscience letters 1999;263(2-3):193-6.
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1999: Erb C; Seidel A; Frank H; Platt K L; Oesch F; Klein J
Formation of N-methylnicotinamide in the brain from a dihydropyridine-type prodrug: effect on brain choline.
Biochemical pharmacology 1999;57(6):681-4.
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1998: Sarri E; Böckmann I; Kempter U; Valeva A; von Eichel-Streiber C; Weichel O; Klein J
Regulation of phospholipase D activity in synaptosomes permeabilized with Staphylococcus aureus alpha-toxin.
FEBS letters 1998;440(3):287-90.
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1998: Henn C; Löffelholz K; Klein J
Stimulatory and inhibitory effects of ethanol on hippocampal acetylcholine release.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(6):640-7.
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1998: Erb C; Klein J
Enhancement of brain choline levels by nicotinamide: mechanism of action.
Neuroscience letters 1998;249(2-3):111-4.
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1998: Klein J; Köppen A; Löffelholz K
Regulation of free choline in rat brain: dietary and pharmacological manipulations.
Neurochemistry international 1998;32(5-6):479-85.
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1998: Klein J; Vakil M; Bergman F; Holler T; Iovino M; Löffelholz K
Glutamatergic activation of hippocampal phospholipase D: postnatal fading and receptor desensitization.
Journal of neurochemistry 1998;70(4):1679-85.
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1997: Köppen A; Klein J; Erb C; Löffelholz K
Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1139-45.
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1997: Erb C; Klein J; Köppen A; Löffelholz K; Jeltsch H; Cassel J C
Modulation of hippocampal acetylcholine release after fimbria-fornix lesions and septal transplantation in rats.
Neuroscience letters 1997;231(1):5-8.
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1997: Klein J; Chatterjee S S; Löffelholz K
Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba.
Brain research 1997;755(2):347-50.
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1997: Klein J; Iovino M; Vakil M; Shinozaki H; Löffelholz K
Ontogenetic and pharmacological studies on metabotropic glutamate receptors coupled to phospholipase D activation.
Neuropharmacology 1997;36(3):305-11.
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1997: Klein J; Reymann K G; Riedel G
Activation of phospholipases C and D by the novel metabotropic glutamate receptor agonist tADA.
Neuropharmacology 1997;36(2):261-3.
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1996: Gonzalez R; Löffelholz K; Klein J
Adrenergic activation of phospholipase D in primary rat astrocytes.
Neuroscience letters 1996;219(1):53-6.
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1996: Köppen A; Klein J; Schmidt B H; van der Staay F J; Löffelholz K
Effects of nicotinamide on central cholinergic transmission and on spatial learning in rats.
Pharmacology, biochemistry, and behavior 1996;53(4):783-90.
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1996: Klein J; Lindmar R; Löffelholz K
Muscarinic activation of phosphatidylcholine hydrolysis.
Progress in brain research 1996;109():201-8.
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1995: Klein J; Chalifa V; Liscovitch M; Löffelholz K
Role of phospholipase D activation in nervous system physiology and pathophysiology.
Journal of neurochemistry 1995;65(4):1445-55.
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1994: Post K; Seidel A; Platt K L; Oesch F; Klein J
Regiospecific reduction of polycyclic aromatic quinones by rabbit liver dihydrodiol dehydrogenases.
Chemico-biological interactions 1994;90(2):157-68.
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1994: Holler T; Klein J; Löffelholz K
Phospholipase C and phospholipase D are independently activated in rat hippocampal slices.
Biochemical pharmacology 1994;47(2):411-4.
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1993: Klein J; Holler T; Cappel E; Köppen A; Löffelholz K
Release of choline from rat brain under hypoxia: contribution from phospholipase A2 but not from phospholipase D.
Brain research 1993;630(1-2):337-40.
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1993: Holler T; Cappel E; Klein J; Löffelholz K
Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats.
Journal of neurochemistry 1993;61(4):1569-72.
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1993: Köppen A; Klein J; Holler T; Löffelholz K
Synergistic effect of nicotinamide and choline administration on extracellular choline levels in the brain.
The Journal of pharmacology and experimental therapeutics 1993;266(2):720-5.
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1993: Klein J; Gonzalez R; Köppen A; Löffelholz K
Free choline and choline metabolites in rat brain and body fluids: sensitive determination and implications for choline supply to the brain.
Neurochemistry international 1993;22(3):293-300.
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1993: Löffelholz K; Klein J; Köppen A
Choline, a precursor of acetylcholine and phospholipids in the brain.
Progress in brain research 1993;98():197-200.
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1992: Klein J; Post K; Seidel A; Frank H; Oesch F; Platt K L
Quinone reduction and redox cycling catalysed by purified rat liver dihydrodiol/3 alpha-hydroxysteroid dehydrogenase.
Biochemical pharmacology 1992;44(2):341-9.
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1992: Klein J; Thomas H; Post K; Wörner W; Oesch F
Dihydrodiol dehydrogenase activities of rabbit liver are associated with hydroxysteroid dehydrogenases and aldo-keto reductases.
European journal of biochemistry / FEBS 1992;205(3):1155-62.
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1992: Klein J; Köppen A; Löffelholz K; Schmitthenner J
Uptake and metabolism of choline by rat brain after acute choline administration.
Journal of neurochemistry 1992;58(3):870-6.
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1991: Klein J; Köppen A; Löffelholz K
Uptake and storage of choline by rat brain: influence of dietary choline supplementation.
Journal of neurochemistry 1991;57(2):370-5.
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1991: Klein J; Seidel A; Frank H; Oesch F; Platt K L
Regiospecific oxidation of polycyclic aromatic dihydrodiols by rat liver dihydrodiol dehydrogenase.
Chemico-biological interactions 1991;79(3):287-303.
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1990: Klein J; Köppen A; Löffelholz K
Small rises in plasma choline reverse the negative arteriovenous difference of brain choline.
Journal of neurochemistry 1990;55(4):1231-6.
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1990: Klein J; Post K; Thomas H; Wörner W; Setiabudi F; Frank H; Oesch F; Platt K L
The oxidation of the highly tumorigenic benz[a]anthracene 3,4-dihydrodiol by rat liver dihydrodiol dehydrogenase.
Chemico-biological interactions 1990;76(2):211-26.
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1989: Glatt H; Padykula R; Berchtold G A; Ludewig G; Platt K L; Klein J; Oesch F
Multiple activation pathways of benzene leading to products with varying genotoxic characteristics.
Environmental health perspectives 1989;82():81-9.
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