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Elizabeth Head

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D Allan Butterfield; giovanna cenini; Fabio Di Domenico; Cesare Mancuso; Michael P Murphy; Rukhsana Sultana; Eugenio Barone; Elizabeth Head
Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain.
Kwang-Mook Jung; Vitaly Vasilevko; Sevil Yasar; Giuseppe Astarita; Carl W Cotman; David H Cribbs; Elizabeth Head; Daniele Piomelli
An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease.
Tommy Saing; David H Cribbs; Malcolm Dick; Ronald C Kim; Peter T Nelson; Elizabeth Head
Frontal cortex neuropathology in dementia pugilistica.

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2012: D Allan Butterfield; giovanna cenini; Fabio Di Domenico; Cesare Mancuso; Michael P Murphy; Rukhsana Sultana; Eugenio Barone; Elizabeth Head
Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2012;15(7):981-7.
2012: Kwang-Mook Jung; Vitaly Vasilevko; Sevil Yasar; Giuseppe Astarita; Carl W Cotman; David H Cribbs; Elizabeth Head; Daniele Piomelli
An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease.
Neurobiology of aging 2012;33(8):1522-32.
2012: Tommy Saing; David H Cribbs; Malcolm Dick; Ronald C Kim; Peter T Nelson; Elizabeth Head
Frontal cortex neuropathology in dementia pugilistica.
Journal of neurotrauma 2012;29(6):1054-70.
2012: Elizabeth Head; Tina L Beckett; Samuel R Bethel; Frederick Bresch; Amy L S Dowling; Mike Grossheim; Katie L McCarty; Heather L Murphey; M Paul Murphy; Jonathan A Nitz; Dieter Pagani; Melanie Pleiss; Jeffery R Smiley; Jenna Vanrooyen; Curt Hendrix
A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2012;32(4):1029-42.
2012: Elizabeth Head; David Patterson; WAYNE SILVERMAN; Ira T Lott
Aging and down syndrome.
Current gerontology and geriatrics research 2012;2012():412536.
2012: Eugenio Barone; Fabio Di Domenico; Elizabeth Head; Cesare Mancuso; M Paul Murphy; Rukhsana Sultana; D Allan Butterfield
Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease.
Journal of neurochemistry 2012;120(1):135-46.
2012: Viorela Pop; Christa M Studzinski; Adam M Weidner; Nicole C Berchtold; Charles G Glabe; Elizabeth Head; M Paul Murphy; Carl W Cotman
Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines.
Neurobiology of aging 2012;33(1):108-20.
2011: Sarah B Martin; Amy L S Dowling; Elizabeth Head
Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model.
Current neuropharmacology 2011;9(4):651-61.
2011: Mike P Hunter; Richard J Kryscio; Michael Kurzer; Marianela Nelson; Graziano Pinna; Xuerong Wang; Elizabeth Head; John P O'Bryan
Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.
Neuroreport 2011;22(15):767-72.
2011: Elizabeth Head
Neurobiology of the aging dog.
Age (Dordrecht, Netherlands) 2011;33(3):485-96.
2011: Sarah B Martin; M Paul Murphy; Cesare Mancuso; Eugenio Barone; D Allan Butterfield; giovanna cenini; Amy L S Dowling; Elizabeth Head
Coenzyme Q10 and cognition in atorvastatin treated dogs.
Neuroscience letters 2011;501(2):92-5.
2011: Ira T Lott; Vinh Q Nguyen; Anne Tournay; Eric Doran; Elizabeth Head; Daniel L Gillen
Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation.
American journal of medical genetics. Part A 2011;155A(8):1939-48.
2011: PETER NELSON; Elizabeth Head; Frederick A Schmitt; Paulina R Davis; Janna H Neltner; Gregory A Jicha; Erin L Abner; Charles D Smith; Linda J Van Eldik; Richard J Kryscio; Stephen W Scheff
Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.
Acta neuropathologica 2011;121(5):571-87.
2011: Emily R Rosario; Lilly Chang; Elizabeth Head; Frank Z Stanczyk; Christian J Pike
Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease.
Neurobiology of aging 2011;32(4):604-13.
2011: Eugenio Barone; giovanna cenini; Fabio Di Domenico; Sarah Martin; Rukhsana Sultana; Cesare Mancuso; Michael Paul Murphy; Elizabeth Head; D Allan Butterfield
Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(3):172-80.
2011: Giuseppe Astarita; Carl W Cotman; David H Cribbs; Nicholas V Dipatrizio; Elizabeth Head; Kwang-Mook Jung; Sarah K Martin; Vitaly Vasilevko; Daniele Piomelli
Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease.
PloS one 2011;6(10):e24777.
2011: Elizabeth Head; Eric Doran; Mihaela Nistor; MaryAnn Hill; Frederick A Schmitt; Richard J Haier; Ira T Lott
Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome.
Journal of Alzheimer's disease : JAD 2011;23(3):399-409.
2010: Vitaly Vasilevko; Giselle F Passos; Daniel Quiring; Elizabeth Head; Richard C Kim; Mark Fisher; David H Cribbs
Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy.
Annals of the New York Academy of Sciences 2010;1207():58-70.
2010: Vitaly Vasilevko; Viorela Pop; Hyun Jin Kim; Tommy Saing; Charles C Glabe; Saskia Milton; Edward G Barrett; Carl W Cotman; David H Cribbs; Elizabeth Head
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta.
Neurobiology of disease 2010;39(3):301-10.
2010: Viorela Pop; Elizabeth Head; Mary-Ann Hill; Dan Gillen; Nicole C Berchtold; Bruce A Muggenburg; Norton W Milgram; M Paul Murphy; Carl W Cotman
Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(29):9831-9.
2010: Donald E Kuhn; Gerard J Nuovo; Alvin V Terry; Mickey M Martin; Geraldine E Malana; Sarah E Sansom; Adam P Pleister; Wayne D Beck; Elizabeth Head; David S Feldman; Terry S Elton
Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains.
The Journal of biological chemistry 2010;285(2):1529-43.
2010: Rakez Kayed; Isabel Canto; Leonid Breydo; Suhail Rasool; Tamas Lukacsovich; Jessica Wu; Ricardo Albay; Anna Pensalfini; Stephen Yeung; Elizabeth Head; J Lawrence Marsh; Charles G Glabe
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers.
Molecular neurodegeneration 2010;5():57.
2010: M Paul Murphy; Jacqueline Morales; Tina L Beckett; Giuseppe Astarita; Daniele Piomelli; Adam Weidner; Christa M Studzinski; Amy L S Dowling; Xiaohong Wang; Harry Levine; Richard J Kryscio; Yushun Lin; Edward Barrett; Elizabeth Head
Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs.
Journal of Alzheimer's disease : JAD 2010;22(1):135-50.
2010: Giuseppe Astarita; Kwang-Mook Jung; Nicole C Berchtold; Vinh Q Nguyen; Daniel L Gillen; Elizabeth Head; Carl W Cotman; Daniele Piomelli
Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease.
PloS one 2010;5(9):e12538.
2010: Pinar E Coskun; Joanne Wyrembak; Olga Derbereva; Goar Melkonian; Eric Doran; Ira T Lott; Elizabeth Head; Carl W Cotman; Douglas C Wallace
Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2():S293-310.
2010: Elizabeth Head; Viorela Pop; Floyd Sarsoza; Rakez Kayed; Tina L Beckett; Christa M Studzinski; Jennifer L Tomic; Charles G Glabe; M Paul Murphy
Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines.
Journal of Alzheimer's disease : JAD 2010;20(2):637-46.
2009: Lori-Ann Christie; Wycliffe O Opii; Elizabeth Head; Joseph Araujo; Christina de Rivera; Norton W Milgram; Carl W Cotman
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.
Experimental gerontology 2009;44(12):752-9.
2009: Elizabeth Head; Vidya N Nukala; Kristina A Fenoglio; B A Muggenburg; Carl W Cotman; Patrick G Sullivan
Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging.
Experimental neurology 2009;220(1):171-6.
2009: James Joseph; Gregory M. Cole; Elizabeth Head; Donald Ingram
Nutrition, brain aging, and neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(41):12795-801.
2009: Floyd Sarsoza; Tommy Saing; Rakez Kayed; Robert Dahlin; Malcolm Dick; Camille Broadwater-Hollifield; Scott Mobley; Ira T Lott; Eric Doran; Daniel Gillen; Clifford Anderson-Bergman; David H Cribbs; Charles G Glabe; Elizabeth Head
A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain.
Acta neuropathologica 2009;118(4):505-17.
2009: Lori-Ann Christie; Wycliffe O Opii; Elizabeth Head
Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines.
Age (Dordrecht, Netherlands) 2009;31(3):211-20.
2009: Jennifer L Tomic; Anna Pensalfini; Elizabeth Head; Charles G Glabe
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction.
Neurobiology of disease 2009;35(3):352-8.
2009: Elizabeth Head; Maria Corrada; Kristin Kahle-Wrobleski; Ronald C Kim; Floyd Sarsoza; Matthew Goodus; Claudia H Kawas
Synaptic proteins, neuropathology and cognitive status in the oldest-old.
Neurobiology of aging 2009;30(7):1125-34.
2009: Vitaly Vasilevko; Elizabeth Head
Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle.
CNS & neurological disorders drug targets 2009;8(2):98-113.
2009: Elizabeth Head
Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging.
Neurochemical research 2009;34(4):670-8.
2009: Dan Berlau; Maria Corrada; Elizabeth Head; Claudia H Kawas
APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old.
Neurology 2009;72(9):829-34.
2009: Rakez Kayed; Anna Pensalfini; Larry Margol; Yuri Sokolov; Floyd Sarsoza; Elizabeth Head; James E Hall; Charles G Glabe
Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer.
The Journal of biological chemistry 2009;284(7):4230-7.
2009: Troy T Rohn; Elizabeth Head
Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase?
International journal of clinical and experimental pathology 2009;2(2):108-18.
2008: Carl W Cotman; Elizabeth Head
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches.
Journal of Alzheimer's disease : JAD 2008;15(4):685-707.
2008: Lori-Ann Christie; Richard C Saunders; Danuta M Kowalska; William A MacKay; Elizabeth Head; Carl W Cotman
Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines.
The Journal of comparative neurology 2008;511(2):257-70.
2008: Nicole C Berchtold; David H Cribbs; Paul D. Coleman; Joseph Rogers; Elizabeth Head; Ronald Kim; Thomas Beach; Carol Miller; Juan C Troncoso; John Q Trojanowski; H Ronald Zielke; Carl W Cotman
Gene expression changes in the course of normal brain aging are sexually dimorphic.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15605-10.
2008: Weili Shen; Kai Liu; Chuan Tian; Lu Yang; Xuesen Li; Jinmin Ren; Lester Packer; Elizabeth Head; Edward Sharman; Jiankang Liu
Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid.
Journal of cellular biochemistry 2008;104(4):1232-43.
2008: Donald E Kuhn; Gerard J Nuovo; Mickey M Martin; Geraldine E Malana; Adam P Pleister; Jinmai Jiang; Thomas D Schmittgen; Alvin V Terry; Katheleen Gardiner; Elizabeth Head; David S Feldman; Terry S Elton
Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts.
Biochemical and biophysical research communications 2008;370(3):473-7.
2008: Elizabeth Head; Viorela Pop; Vitaly Vasilevko; MaryAnn Hill; Tommy Saing; Floyd Sarsoza; Michaela Nistor; Lori-Ann Christie; Saskia Milton; Charles G Glabe; Edward Barrett; David H Cribbs
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(14):3555-66.
2008: Troy T Rohn; Veera Vyas; Tatiana Hernandez-Estrada; Kathryn E Nichol; Lori-Ann Christie; Elizabeth Head
Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(12):3051-9.
2008: Richard J Haier; Kevin Head; Elizabeth Head; Ira T Lott
Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events.
NeuroImage 2008;39(3):1324-32.
2008: Troy T Rohn; Elizabeth Head
Caspase activation in Alzheimer's disease: early to rise and late to bed.
Reviews in the neurosciences 2008;19(6):383-93.
2008: Nina Movsesyan; Anahit Ghochikyan; Mkrtichyan Mikayel; Irina Petrushina; Hayk Davtyan; Purevdorj B Olkhanud; Elizabeth Head; Arya Biragyn; David H Cribbs; Michael G Agadjanyan
Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.
PloS one 2008;3(5):e2124.
2008: Elizabeth Head; Jaime Rofina; Steven C Zicker
Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging.
The Veterinary clinics of North America. Small animal practice 2008;38(1):167-78, vi.
2008: Christina T Siwak-Tapp; Elizabeth Head; Bruce A Muggenburg; Norton W Milgram; Carl W Cotman
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment.
Neurobiology of aging 2008;29(1):39-50.
2008: Wycliffe O Opii; Gururaj Joshi; Elizabeth Head; Norton W Milgram; Bruce A Muggenburg; Klein Jon; William M Pierce; Carl W Cotman; D Allan Butterfield
Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease.
Neurobiology of aging 2008;29(1):51-70.
2007: Irina Petrushina; Anahit Ghochikyan; Mikayel Mktrichyan; Gregory Mamikonyan; Nina Movsesyan; Hayk Davtyan; Archita Patel; Elizabeth Head; David H Cribbs; Michael G Agadjanyan
Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(46):12721-31.
2007: Elizabeth Head
Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging.
Annals of the New York Academy of Sciences 2007;1114():398-406.
2007: Danièlle Gunn-Moore; K Moffat; L-A Christie; Elizabeth Head
Cognitive dysfunction and the neurobiology of ageing in cats.
The Journal of small animal practice 2007;48(10):546-53.
2007: Mihaela Nistor; M Don; M Parekh; Floyd Sarsoza; M Goodus; G E Lopez; Claudia H Kawas; James B Leverenz; Eric Doran; Ira T Lott; M Hill; Elizabeth Head
Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain.
Neurobiology of aging 2007;28(10):1493-506.
2007: Christina T Siwak-Tapp; Elizabeth Head; Bruce A Muggenburg; Norton W Milgram; Carl W Cotman
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function.
Neurobiology of learning and memory 2007;88(2):249-59.
2007: Dan Berlau; Kristin Kahle-Wrobleski; Elizabeth Head; Matthew Goodus; Ronald Kim; Claudia H Kawas
Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype.
Archives of neurology 2007;64(8):1193-6.
2007: Elizabeth Head; Ira T Lott; D Patterson; Eric Doran; Richard J Haier
Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention.
Journal of Alzheimer's disease : JAD 2007;11(1):61-76.
2007: Rakez Kayed; Elizabeth Head; Floyd Sarsoza; Tommy Saing; Carl W Cotman; Mihaela Necula; Lawrence Margol; Jessica Wu; Leonid Breydo; Jennifer L Thompson; Suhail Rasool; Tatyana Gurlo; Peter Butler; Charles G Glabe
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.
Molecular neurodegeneration 2007;2():18.
2006: Ira T Lott; Elizabeth Head; Eric Doran; Jorge Busciglio
Beta-amyloid, oxidative stress and down syndrome.
Current Alzheimer research 2006;3(5):521-8.
2006: Charles Chubb; Yoshiyuki Inagaki; Phillip Sheu; Brian John Cummings; Andrea Wasserman; Elizabeth Head; Carl W Cotman
BioVision: an application for the automated image analysis of histological sections.
Neurobiology of aging 2006;27(10):1462-76.
2006: Christa M Studzinski; Lori-Ann Christie; Joseph Araujo; W McIntyre Burnham; Elizabeth Head; Carl W Cotman; Norton W Milgram
Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia.
Neurobiology of learning and memory 2006;86(2):197-204.
2006: Norton W Milgram; Christina T Siwak-Tapp; Joseph Araujo; Elizabeth Head
Neuroprotective effects of cognitive enrichment.
Ageing research reviews 2006;5(3):354-69.
2006: Elizabeth Head; Arnold Starr; Ronald C Kim; Anna Parachikova; Genaro E Lopez; Malcolm Dick; David H Cribbs
Relapsing polychondritis with features of dementia with Lewy bodies.
Acta neuropathologica 2006;112(2):217-25.
2006: Danièlle Gunn-Moore; Jill McVee; Janet M Bradshaw; Geoffrey R Pearson; Elizabeth Head; Frank J Gunn-Moore
Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits.
Journal of feline medicine and surgery 2006;8(4):234-42.
2006: Elizabeth Head; Edward G Barrett; Michael Murphy; Pritam Das; Mihaela Nistor; Floyd Sarsoza; Charles C Glabe; Rakez Kayed; Saskia Milton; Vitaly Vasilevko; Norton W Milgram; Michael G Agadjanyan; David H Cribbs; Carl W Cotman
Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.
Vaccine 2006;24(15):2824-34.
2006: Peter E Mouser; Elizabeth Head; Kwang-Ho Ha; Troy T Rohn
Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain.
The American journal of pathology 2006;168(3):936-46.
2006: P Dwight Tapp; Kevin Head; Elizabeth Head; Norton W Milgram; Bruce A Muggenburg; Min-Ying Su
Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging.
NeuroImage 2006;29(1):234-44.
2005: Philip Roudebush; Steven C Zicker; Carl W Cotman; Norton W Milgram; Bruce A Muggenburg; Elizabeth Head
Nutritional management of brain aging in dogs.
Journal of the American Veterinary Medical Association 2005;227(5):722-8.
2005: Jodie Newman; Robert A Rissman; Floyd Sarsoza; Ronald C Kim; Malcolm Dick; David A Bennett; Carl W Cotman; Troy T Rohn; Elizabeth Head
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.
Acta neuropathologica 2005;110(2):135-44.
2005: Elizabeth Head; K Moffat; Pritam Das; Floyd Sarsoza; Wayne W Poon; G Landsberg; Carl W Cotman; Michael Murphy
Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats.
Neurobiology of aging 2005;26(5):749-63.
2005: Pablo Helguera; Alejandra Pelsman; Gustavo Pigino; Ernst Wolvetang; Elizabeth Head; Jorge Busciglio
ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(9):2295-303.
2005: Joseph A Araujo; Carl W Cotman; Elizabeth Head; Christa M Studzinski; Norton W Milgram
Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging.
Age (Dordrecht, Netherlands) 2005;27(1):27-37.
2005: Christina T Siwak; P Dwight Tapp; Elizabeth Head; Steven C Zicker; Heather Murphey; Bruce A Muggenburg; Candace J Ikeda-Douglas; Carl W Cotman; Norton W Milgram
Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs.
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(3):461-9.
2005: Linda Nelson; Julene K Johnson; Morris Freedman; Ira T Lott; Jantje Groot; Marisa Chang; Norton W Milgram; Elizabeth Head
Learning and memory as a function of age in Down syndrome: a study using animal-based tasks.
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(3):443-53.
2005: P Dwight Tapp; Yong Chu; Joseph Araujo; Jr-Yuan Chiou; Elizabeth Head; Norton W Milgram; Min-Ying Su
Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging.
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(3):399-406.
2005: Min-Ying Su; P Dwight Tapp; Long Vu; Ya-Fang Chen; Yong Chu; Bruce A Muggenburg; Jr-Yuan Chiou; Changqing Chen; Jun Wang; Christian Bracco; Elizabeth Head
A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging.
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(3):389-97.
2005: Lori-Ann Christie; Christa M Studzinski; Joseph Araujo; Cleo S K Leung; Candace J Ikeda-Douglas; Elizabeth Head; Carl W Cotman; Norton W Milgram
A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog.
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(3):361-9.
2005: Ira T Lott; Elizabeth Head
Alzheimer disease and Down syndrome: factors in pathogenesis.
Neurobiology of aging 2005;26(3):383-9.
2005: Stefani N Thomas; Brian A Soreghan; Mihaela Nistor; Floyd Sarsoza; Elizabeth Head; Austin Yang
Reduced neuronal expression of synaptic transmission modulator HNK-1/neural cell adhesion molecule as a potential consequence of amyloid beta-mediated oxidative stress: a proteomic approach.
Journal of neurochemistry 2005;92(4):705-17.
2005: Norton W Milgram; Elizabeth Head; Steven C Zicker; Candace J Ikeda-Douglas; Heather Murphey; Bruce A Muggenburg; Christina T Siwak; D Tapp; Carl W Cotman
Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study.
Neurobiology of aging 2005;26(1):77-90.
2004: Jiankang Liu; Elizabeth Head; Hirohiko Kuratsune; Carl W Cotman; Bruce N Ames
Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats.
Annals of the New York Academy of Sciences 2004;1033():117-31.
2004: P Dwight Tapp; Christina T Siwak; Fu Qiang Gao; Jr-Yuan Chiou; Sandra Black; Elizabeth Head; Bruce A Muggenburg; Carl W Cotman; Norton W Milgram; Min-Ying Su
Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(38):8205-13.
2004: P Dwight Tapp; Christina T Siwak; Elizabeth Head; Carl W Cotman; Heather Murphey; Bruce A Muggenburg; Candace J Ikeda-Douglas; Norton W Milgram
Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks.
Behavioural brain research 2004;153(1):199-210.
2004: Norton W Milgram; Elizabeth Head; Steven C Zicker; Candace J Ikeda-Douglas; Heather Murphey; Bruce A Muggenberg; Christina T Siwak; P Dwight Tapp; Stephen R Lowry; Carl W Cotman
Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs.
Experimental gerontology 2004;39(5):753-65.
2004: Elizabeth Head; Ira T Lott
Down syndrome and beta-amyloid deposition.
Current opinion in neurology 2004;17(2):95-100.
2004: Julene K Johnson; Brent A Vogt; Ronald Kim; Carl W Cotman; Elizabeth Head
Isolated executive impairment and associated frontal neuropathology.
Dementia and geriatric cognitive disorders 2004;17(4):360-7.
2004: Elizabeth Head; Steven C Zicker
Nutraceuticals, aging, and cognitive dysfunction.
The Veterinary clinics of North America. Small animal practice 2004;34(1):217-28.
2003: Richard J Haier; Michael T Alkire; Nathan White; M R Uncapher; Elizabeth Head; Ira T Lott; Carl W Cotman
Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia.
Neurology 2003;61(12):1673-9.
2003: Ming Zhao; Joseph Su; Elizabeth Head; Carl W Cotman
Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease.
Neurobiology of disease 2003;14(3):391-403.
2003: Anahit Ghochikyan; Vitaly Vasilevko; Irina Petrushina; Nina Movsesyan; Davit Babikyan; Wenqiang Tian; Nadya Sadzikava; Ted M Ross; Elizabeth Head; David H Cribbs; Michael G Agadjanyan
Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene.
European journal of immunology 2003;33(12):3232-41.
2003: Pria M D Nippak; Alan D F Chan; Zachariah Campbell; Bruce A Muggenburg; Elizabeth Head; Candace J Ikeda-Douglas; Heather Murphey; Carl W Cotman; Norton W Milgram
Response latency in Canis familiaris: mental ability or mental strategy?
Behavioral neuroscience 2003;117(5):1066-75.
2003: Xiaoning Bi; Elizabeth Head; Carl W Cotman; Gary Lynch
Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease.
The Journal of comparative neurology 2003;464(3):371-81.
2003: Elizabeth Head; Ira T Lott; Patrick R Hof; Constantin Bouras; Joseph H Su; R Kim; Richard J Haier; Carl W Cotman
Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome.
Journal of neuropathology and experimental neurology 2003;62(9):917-26.
2003: Christina T Siwak; P Dwight Tapp; Steven C Zicker; Heather Murphey; Bruce A Muggenburg; Elizabeth Head; Carl W Cotman; Norton W Milgram
Locomotor activity rhythms in dogs vary with age and cognitive status.
Behavioral neuroscience 2003;117(4):813-24.
2003: Rakez Kayed; Elizabeth Head; Jennifer L Thompson; Theresa M McIntire; Saskia Milton; Carl W Cotman; Charles G Glabe
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.
Science (New York, N.Y.) 2003;300(5618):486-9.
2003: Reidun Torp; Ole Petter Ottersen; Carl W Cotman; Elizabeth Head
Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing.
Neuroscience 2003;120(2):291-300.
2003: P Dwight Tapp; Christina T Siwak; Jimena Estrada; Elizabeth Head; Bruce A Muggenburg; Carl W Cotman; Norton W Milgram
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging.
Learning & memory (Cold Spring Harbor, N.Y.) 2003;10(1):64-73.
2002: Troy T Rohn; Robert A Rissman; Michael C Davis; Young Eun Kim; Carl W Cotman; Elizabeth Head
Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.
Neurobiology of disease 2002;11(2):341-54.
2002: Gjumrakch Aliev; Dilara Seyidova; Maxwell Neal; Jiong Shi; Bruce Lamb; Sandra L Siedlak; Harry V Vinters; Elizabeth Head; George Perry; Joseph C LaManna; Robert P Friedland; Carl W Cotman
Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.
Annals of the New York Academy of Sciences 2002;977():45-64.
2002: Norton W Milgram; Elizabeth Head; Bruce A Muggenburg; Daniel Holowachuk; Heather Murphey; Jimena Estrada; Candace J Ikeda-Douglas; Steven C Zicker; Carl W Cotman
Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy.
Neuroscience and biobehavioral reviews 2002;26(6):679-95.
2002: Elizabeth Head; Ira T Lott; David H Cribbs; Carl W Cotman; Troy T Rohn
Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome.
Neuroscience letters 2002;330(1):99-103.
2002: Carl W Cotman; Elizabeth Head; Bruce A Muggenburg; Steven C Zicker; Norton W Milgram
Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction.
Neurobiology of aging 2002;23(5):809-18.
2002: Norton W Milgram; Steven C Zicker; Elizabeth Head; Bruce A Muggenburg; Heather Murphey; Candace J Ikeda-Douglas; Carl W Cotman
Dietary enrichment counteracts age-associated cognitive dysfunction in canines.
Neurobiology of aging 2002;23(5):737-45.
2002: Elizabeth Head; J Liu; Tory M Hagen; Bruce A Muggenburg; Norton W Milgram; B N Ames; Carl W Cotman
Oxidative damage increases with age in a canine model of human brain aging.
Journal of neurochemistry 2002;82(2):375-81.
2002: Joseph H Su; J Patrick Kesslak; Elizabeth Head; Carl W Cotman
Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain.
Acta neuropathologica 2002;104(1):1-6.
2002: Alan D F Chan; Pria M D Nippak; Heather Murphey; Candace J Ikeda-Douglas; Bruce A Muggenburg; Elizabeth Head; Carl W Cotman; Norton W Milgram
Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility.
Behavioral neuroscience 2002;116(3):443-54.
2002: Jiankang Liu; Elizabeth Head; Afshin M Gharib; Wenjun Yuan; Russell T Ingersoll; Tory M Hagen; Carl W Cotman; Bruce N Ames
Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2356-61.
2002: Elizabeth Head; Reidun Torp
Insights into Abeta and presenilin from a canine model of human brain aging.
Neurobiology of disease 2002;9(1):1-10.
2001: Troy T Rohn; Elizabeth Head; W H Nesse; Carl W Cotman; David H Cribbs
Activation of caspase-8 in the Alzheimer's disease brain.
Neurobiology of disease 2001;8(6):1006-16.
2001: Elizabeth Head; W Garzon-Rodriguez; J K Johnson; Ira T Lott; Carl W Cotman; Charles G Glabe
Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome.
Neurobiology of disease 2001;8(5):792-806.
2001: Elizabeth Head; BY Azizeh; Ira T Lott; Andrea J Tenner; Carl W Cotman; David H Cribbs
Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.
Neurobiology of disease 2001;8(2):252-65.
2001: Elizabeth Head
Brain aging in dogs: parallels with human brain aging and Alzheimer's disease.
Veterinary therapeutics : research in applied veterinary medicine 2001;2(3):247-60.
2001: Ira T Lott; Elizabeth Head
Down syndrome and Alzheimer's disease: a link between development and aging.
Mental retardation and developmental disabilities research reviews 2001;7(3):172-8.
2001: Troy T Rohn; Elizabeth Head; Joseph H Su; Aileen J Anderson; Ben A Bahr; Carl W Cotman; David H Cribbs
Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease.
The American journal of pathology 2001;158(1):189-98.
2000: Reidun Torp; Elizabeth Head; Carl W Cotman
Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane.
Progress in neuro-psychopharmacology & biological psychiatry 2000;24(5):801-10.
2000: Elizabeth Head; P L Thornton; L Tong; Carl W Cotman
Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging.
Progress in neuro-psychopharmacology & biological psychiatry 2000;24(5):777-86.
2000: H Callahan; Candace J Ikeda-Douglas; Elizabeth Head; Carl W Cotman; Norton W Milgram
Development of a protocol for studying object recognition memory in the dog.
Progress in neuro-psychopharmacology & biological psychiatry 2000;24(5):693-707.
2000: Elizabeth Head; Carl W Cotman; Norton W Milgram
Canine cognition, aging and neuropathology. Introduction.
Progress in neuro-psychopharmacology & biological psychiatry 2000;24(5):671-3.
2000: BY Azizeh; Elizabeth Head; M A Ibrahim; Reidun Torp; Andrea J Tenner; Ronald C Kim; Ira T Lott; Carl W Cotman
Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs.
Experimental neurology 2000;163(1):111-22.
2000: B Adams; A Chan; H Callahan; Christina T Siwak; D Tapp; Candace J Ikeda-Douglas; P Atkinson; Elizabeth Head; Carl W Cotman; Norton W Milgram
Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog.
Behavioural brain research 2000;108(1):47-56.
2000: Elizabeth Head; R McCleary; Fletcher Hahn; Norton W Milgram; Carl W Cotman
Region-specific age at onset of beta-amyloid in dogs.
Neurobiology of aging 2000;21(1):89-96.
2000: Reidun Torp; Elizabeth Head; N W Milgram; F Hahn; Ole Petter Ottersen; Carl W Cotman
Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains.
Neuroscience 2000;96(3):495-506.
1999: J K Johnson; Elizabeth Head; R Kim; Arnold Starr; Carl W Cotman
Clinical and pathological evidence for a frontal variant of Alzheimer disease.
Archives of neurology 1999;56(10):1233-9.
1999: Maria I Fonseca; Elizabeth Head; Peter Velazquez; Carl W Cotman; Andrea J Tenner
The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.
Experimental neurology 1999;157(2):277-88.
1999: Norton W Milgram; B Adams; H Callahan; Elizabeth Head; B Mackay; C Thirlwell; Carl W Cotman
Landmark discrimination learning in the dog.
Learning & memory (Cold Spring Harbor, N.Y.) 1999;6(1):54-61.
1998: Min-Ying Su; Elizabeth Head; W M Brooks; Z Wang; Bruce A Muggenburg; G E Adam; R Sutherland; Carl W Cotman; O Nalcioglu
Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging.
Neurobiology of aging 1998;19(5):479-85.
1998: Elizabeth Head; H Callahan; Bruce A Muggenburg; Carl W Cotman; Norton W Milgram
Visual-discrimination learning ability and beta-amyloid accumulation in the dog.
Neurobiology of aging 1998;19(5):415-25.
1998: Candace J Ikeda-Douglas; Elizabeth Head; R. M. Damian Holsinger; L Tremblay; RJ Racine; Norton W Milgram
Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures.
Epilepsy research 1998;31(2):143-52.
1998: WW Ruehl; J Neilson; B Hart; Elizabeth Head; David Bruyette; Brian John Cummings
Therapeutic actions of L-deprenyl in dogs: a model of human brain aging.
Advances in pharmacology (San Diego, Calif.) 1998;42():316-9.
1997: S Cammisuli; Michael Murphy; Candace J Ikeda-Douglas; V Balkissoon; R. M. Damian Holsinger; Elizabeth Head; M Michael; RJ Racine; Norton W Milgram
Effects of extended electrical kindling on exploratory behavior and spatial learning.
Behavioural brain research 1997;89(1-2):179-90.
1997: T Satou; Brian John Cummings; Elizabeth Head; K A Nielson; Fletcher Hahn; Norton W Milgram; Peter Velazquez; David H Cribbs; Andrea J Tenner; Carl W Cotman
The progression of beta-amyloid deposition in the frontal cortex of the aged canine.
Brain research 1997;774(1-2):35-43.
1997: Elizabeth Head; H Callahan; Brian John Cummings; Carl W Cotman; WW Ruehl; B A Muggenberg; Norton W Milgram
Open field activity and human interaction as a function of age and breed in dogs.
Physiology & behavior 1997;62(5):963-71.
1996: Brian John Cummings; T Satou; Elizabeth Head; Norton W Milgram; Gregory M. Cole; Mary J Savage; M B Podlisny; Dennis J Selkoe; R Siman; Benjamin D Greenberg; Carl W Cotman
Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs.
Neurobiology of aging 1996;17(4):653-9.
1996: Brian John Cummings; Elizabeth Head; A J Afagh; Norton W Milgram; Carl W Cotman
Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine.
Neurobiology of learning and memory 1996;66(1):11-23.
1996: Elizabeth Head; J Hartley; A M Kameka; R Mehta; Gwen O Ivy; WW Ruehl; Norton W Milgram
The effects of L-deprenyl on spatial short term memory in young and aged dogs.
Progress in neuro-psychopharmacology & biological psychiatry 1996;20(3):515-30.
1996: Brian John Cummings; Elizabeth Head; WW Ruehl; Norton W Milgram; Carl W Cotman
The canine as an animal model of human aging and dementia.
Neurobiology of aging 1996;17(2):259-68.
1995: Elizabeth Head; R Mehta; J Hartley; M Kameka; Brian John Cummings; Carl W Cotman; WW Ruehl; Norton W Milgram
Spatial learning and memory as a function of age in the dog.
Behavioral neuroscience 1995;109(5):851-8.
1995: Norton W Milgram; Gwen O Ivy; Michael Murphy; Elizabeth Head; P H Wu; WW Ruehl; P H Yu; D A Durden; B A Davis; A A Boulton
Effects of chronic oral administration of L-deprenyl in the dog.
Pharmacology, biochemistry, and behavior 1995;51(2-3):421-8.
1995: Norton W Milgram; M Michael; S Cammisuli; Elizabeth Head; Janina Ferbinteanu; C Reid; Michael Murphy; R Racine
Development of spontaneous seizures over extended electrical kindling. II. Persistence of dentate inhibitory suppression.
Brain research 1995;670(1):112-20.
1995: WW Ruehl; David Bruyette; A DePaoli; Carl W Cotman; Elizabeth Head; Norton W Milgram; Brian John Cummings
Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy.
Progress in brain research 1995;106():217-25.
1994: Gwen O Ivy; J T Rick; Michael Murphy; Elizabeth Head; C Reid; Norton W Milgram
Effects of L-deprenyl on manifestations of aging in the rat and dog.
Annals of the New York Academy of Sciences 1994;717():45-59.
1994: Norton W Milgram; Elizabeth Head; E Weiner; E Thomas
Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks.
Behavioral neuroscience 1994;108(1):57-68.
1994: M C Carrillo; Gwen O Ivy; Norton W Milgram; Elizabeth Head; P Wu; K Kitani
(-)Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain.
Life sciences 1994;54(20):1483-9.
1993: Norton W Milgram; Gwen O Ivy; Elizabeth Head; Michael Murphy; P H Wu; WW Ruehl; P H Yu; D A Durden; B A Davis; IA Paterson
The effect of L-deprenyl on behavior, cognitive function, and biogenic amines in the dog.
Neurochemical research 1993;18(12):1211-9.
1992: Elizabeth Head; Norton W Milgram
Changes in spontaneous behavior in the dog following oral administration of L-deprenyl.
Pharmacology, biochemistry, and behavior 1992;43(3):749-57.