FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Bruce Lamb

Research Profile

Living Beings

Chemicals & Drugs

Disorders

Devices

Yeast Artificial Chromosomes

Anatomy

Co-author Network

Publications

TOP 3
D L Vogt; D Thomas; D E Bredesen; Veronica Galvan; Bruce Lamb; Sanjay Pimplikar
Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain.
Sungho Lee; Nicholas H Varvel; Megan E Konerth; Guixiang Xu; Astrid E Cardona; Richard M Ransohoff; Bruce Lamb
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
Jianxin Tan; Guozhang Mao; Mei-Zhen Cui; Bruce Lamb; Man-Sun Sy; Xuemin Xu
Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta-amyloid peptide.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Bruce Lamb (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2011: D L Vogt; D Thomas; D E Bredesen; Veronica Galvan; Bruce Lamb; Sanjay Pimplikar
Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain.
Neurobiology of aging 2011;32(9):1725-9.
2010: Sungho Lee; Nicholas H Varvel; Megan E Konerth; Guixiang Xu; Astrid E Cardona; Richard M Ransohoff; Bruce Lamb
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
The American journal of pathology 2010;177(5):2549-62.
2009: Jianxin Tan; Guozhang Mao; Mei-Zhen Cui; Bruce Lamb; Man-Sun Sy; Xuemin Xu
Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta-amyloid peptide.
Neurobiology of disease 2009;36(3):453-60.
2009: Gjumrakch Aliev; Hector H Palacios; Amanda E Lipsitt; Kathryn Fischbach; Bruce Lamb; Mark E Obrenovich; Ludis Morales; Eldar Gasimov; Valentin Bragin
Nitric oxide as an initiator of brain lesions during the development of Alzheimer disease.
Neurotoxicity research 2009;16(3):293-305.
2009: Virgil Muresan; Nicholas H Varvel; Bruce Lamb; Zoia Muresan
The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(11):3565-78.
2009: Kiran Bhaskar; Megan Miller; Alexandra Chludzinski; Karl Herrup; Michael Zagorski; Bruce Lamb
The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events.
Molecular neurodegeneration 2009;4():14.
2008: Jianxin Tan; Guozhang Mao; Mei-Zhen Cui; Shin-Chung Kang; Bruce Lamb; Boon-Seng Wong; Man-Sun Sy; xuemin xu
Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model.
Journal of neurochemistry 2008;107(3):722-33.
2008: Nicholas H Varvel; Kiran Bhaskar; Anita Patil; Sanjay Pimplikar; Karl Herrup; Bruce Lamb
Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(43):10786-93.
2008: Davis Ryman; Yuan Gao; Bruce Lamb
Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease.
Neurobiology of aging 2008;29(8):1190-8.
2008: Qingguang Jiang; C Y Daniel Lee; Shweta Mandrekar; Brandy Wilkinson; Paige Cramer; Noam Zelcer; Karen Mann; Bruce Lamb; Timothy M Willson; Jon L Collins; Jill C Richardson; Jonathan D. Smith; thomas Comery; David Riddell; David M Holtzman; Peter Tontonoz; Gary Landreth
ApoE promotes the proteolytic degradation of Abeta.
Neuron 2008;58(5):681-93.
2007: Matthew J Chiocco; Bruce Lamb
Spatial and temporal control of age-related APP processing in genomic-based beta-secretase transgenic mice.
Neurobiology of aging 2007;28(1):75-84.
2006: Davis Ryman; Bruce Lamb
Genetic and environmental modifiers of Alzheimer's disease phenotypes in the mouse.
Current Alzheimer research 2006;3(5):465-73.
2006: Ahmad Salehi; Jean-Dominique Delcroix; Pavel V Belichenko; Ke Zhan; Chengbiao Wu; Janice S Valletta; Ryoko Takimoto-Kimura; Alexander M Kleschevnikov; Kumar Sambamurti; Peter P Chung; Weiming Xia; Angela Villar; William A Campbell; Laura Shapiro Kulnane; Ralph A. Nixon; Bruce Lamb; Charles J Epstein; Gorazd B Stokin; Lawrence S B Goldstein; William C. Mobley
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Neuron 2006;51(1):29-42.
2006: Yan Yang; Nicholas H Varvel; Bruce Lamb; Karl Herrup
Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(3):775-84.
2005: Kirsten K Youngren; Douglas Coveney; Xiaoning Peng; Chitralekha Bhattacharya; Laura S Schmidt; Michael L Nickerson; Bruce Lamb; Jian Min Deng; Richard R Behringer; Blanche Capel; Edward M Rubin; Joseph H Nadeau; Angabin Matin
The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.
Nature 2005;435(7040):360-4.
2005: Jeffery J Anderson; Greg Holtz; Patricia P Baskin; Mary Turner; Blake Rowe; Bowei Wang; Maria Z Kounnas; Bruce Lamb; Donna M Barten; Kevin M Felsenstein; Ian McDonald; Kumar Srinivasan; Ben Munoz; Steven L Wagner
Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.
Biochemical pharmacology 2005;69(4):689-98.
2004: Matthew J Chiocco; Laura Shapiro Kulnane; Linda Younkin; Steven G Younkin; Geneviève Evin; Bruce Lamb
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
The Journal of biological chemistry 2004;279(50):52535-42.
2004: W Haung Yu; Asok Kumar; Corrinne M Peterhoff; L Shapiro Kulnane; Y Uchiyama; Bruce Lamb; Ana Maria Cuervo; Ralph A. Nixon
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.
The international journal of biochemistry & cell biology 2004;36(12):2531-40.
2004: Karen M Mann; Fayanne E Thorngate; Yuko Katoh-Fukui; Hiroki Hamanaka; David L Williams; Shinobu Fujita; Bruce Lamb
Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model.
Human molecular genetics 2004;13(17):1959-68.
2004: Ali Aliyev; Dilara Seyidova; Nizami Rzayev; Mark E Obrenovich; Bruce Lamb; Shu G Chen; Mark A. Smith; George Perry; Jack C. de la Torre; Gjumrakch Aliev
Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?
Neurological research 2004;26(5):547-53.
2004: Dilara Seyidova; Ali Aliyev; Nizami Rzayev; Mark E Obrenovich; Bruce Lamb; Mark A. Smith; Jack C. de la Torre; George Perry; Gjumrakch Aliev
The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease.
In vivo (Athens, Greece) 2004;18(3):325-33.
2004: Catherine Harris-Cerruti; Ariel Kamsler; Batia Kaplan; Bruce Lamb; Menahem Segal; Yoram Groner
Functional and morphological alterations in compound transgenic mice overexpressing Cu/Zn superoxide dismutase and amyloid precursor protein [correction].
The European journal of neuroscience 2004;19(5):1174-90.
2003: Emily J H Lehman; Laura Shapiro Kulnane; Yuan Gao; Michelle C Petriello; Karen M Pimpis; Linda Younkin; Georgia Dolios; Rong Wang; Steven G Younkin; Bruce Lamb
Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse.
Human molecular genetics 2003;12(22):2949-56.
2003: Gjumrakch Aliev; Dilara Seyidova; Bruce Lamb; Mark E Obrenovich; Sandra L Siedlak; Harry V Vinters; Robert P Friedland; Joseph C LaManna; Mark A. Smith; George Perry
Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice.
Neurological research 2003;25(6):665-74.
2003: Emily J H Lehman; Laura Shapiro Kulnane; Bruce Lamb
Alterations in beta-amyloid production and deposition in brain regions of two transgenic models.
Neurobiology of aging 2003;24(5):645-53.
2003: Kara E Koehler; Robert C Voigt; Sally Thomas; Bruce Lamb; Cheryl Urban; Terry Hassold; Patricia A Hunt
When disaster strikes: rethinking caging materials.
Lab animal 2003;32(4):24-7.
2002: Gjumrakch Aliev; Dilara Seyidova; Maxwell Neal; Jiong Shi; Bruce Lamb; Sandra L Siedlak; Harry V Vinters; Elizabeth Head; George Perry; Joseph C LaManna; Robert P Friedland; Carl W Cotman
Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.
Annals of the New York Academy of Sciences 2002;977():45-64.
2002: Laura Shapiro Kulnane; Emily J H Lehman; Brian J Hock; Karen D Tsuchiya; Bruce Lamb
Rapid and efficient detection of transgene homozygosity by FISH of mouse fibroblasts.
Mammalian genome : official journal of the International Mammalian Genome Society 2002;13(4):223-6.
2002: Gjumrakch Aliev; Mark A. Smith; Dilara Seyidov; Maxwell Neal; Bruce Lamb; Akihiko Nunomura; Eldar K Gasimov; Harry V Vinters; George Perry; Joseph C LaManna; Robert P Friedland
The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease.
Brain pathology (Zurich, Switzerland) 2002;12(1):21-35.
2001: Laura Shapiro Kulnane; Bruce Lamb
Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice.
Neurobiology of disease 2001;8(6):982-92.
2001: Roger H Reeves; Deborah E Cabin; Bruce Lamb
Introduction of large insert DNA into mammalian cells and embryos.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2001;Chapter 5():Unit 5.12.
2001: B J Hock; Bruce Lamb
Transgenic mouse models of Alzheimer's disease.
Trends in genetics : TIG 2001;17(10):S7-12.
2000: A Jakobovits; Bruce Lamb; K R Peterson
Production of transgenic mice with yeast artificial chromosomes.
Methods in molecular biology (Clifton, N.J.) 2000;136():435-53.
1999: Bruce Lamb; K A Bardel; Laura Shapiro Kulnane; J J Anderson; Greg Holtz; Steven L Wagner; Sangram S Sisodia; E J Hoeger
Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.
Nature neuroscience 1999;2(8):695-7.
1997: Bruce Lamb; LM Call; Hilda H Slunt; K A Bardel; Ann M Lawler; Christopher B Eckman; Steven G Younkin; Greg Holtz; Steven L Wagner; Donald L Price; Sangram S Sisodia; John D Gearhart
Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.
Human molecular genetics 1997;6(9):1535-41.
1997: Bruce Lamb
Presenilins, amyloid-beta and Alzheimer's disease.
Nature medicine 1997;3(1):28-9.
1996: Noel Y Calingasan; Sam Gandy; H Baker; KF Sheu; Jonathan D. Smith; Bruce Lamb; John D Gearhart; Joseph Buxbaum; C Harper; Dennis J Selkoe; Donald L Price; Sangram S Sisodia; Gary Gibson
Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.
The American journal of pathology 1996;149(3):1063-71.
1996: C Rosenberg; A K Voltz; Ann M Lawler; Bruce Lamb; Gail Stetten; John D Gearhart
Alterations of yeast artificial chromosome transgenic sequences in stretched embryonic stem-cell chromatin visualized by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1996;75(1):67-70.
1995: Bruce Lamb; John D Gearhart
YAC transgenics and the study of genetics and human disease.
Current opinion in genetics & development 1995;5(3):342-8.
1995: Bruce Lamb
Making models for Alzheimer's disease.
Nature genetics 1995;9(1):4-6.
1993: Bruce Lamb; Sangram S Sisodia; Ann M Lawler; Hilda H Slunt; C A Kitt; William G Kearns; P L Pearson; Donald L Price; John D Gearhart
Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected].
Nature genetics 1993;5(1):22-30.
1992: Bruce Lamb; Kapaettu Satyamoorthy; D Solter; A Basu; M Q Xu; roberto weinmann; CC Howe
A DNA element that regulates expression of an endogenous retrovirus during F9 cell differentiation is E1A dependent.
Molecular and cellular biology 1992;12(11):4824-33.
1991: Bruce Lamb; Kapaettu Satyamoorthy; L Li; D Solter; CC Howe
CpG methylation of an endogenous retroviral enhancer inhibits transcription factor binding and activity.
Gene expression 1991;1(3):185-96.
1988: R S Tuan; Bruce Lamb; C B Jesinkey
Mouse placental 57-kDa calcium-binding protein: II. Localization of mRNA in mouse and human placentae by in situ cDNA hybridization.
Differentiation; research in biological diversity 1988;37(3):198-204.