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Jeff Keller

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Dana M Niedowicz; Thomas L Platt; Christa M Studzinski; Adam M Weidner; Tina L Beckett; Annadora J Bruce-Keller; Jeff Keller; Kristen N Kingry; M Paul Murphy
Leptin regulates amyloid β production via the γ-secretase complex.
Linnea R Freeman; Anand Nair; Le Zhang; Annadora J Bruce-Keller; Kalavathi Dasuri; Sun-Ok Fernandez-Kim; Joseph Francis; Jeff Keller
Obesity increases cerebrocortical reactive oxygen species and impairs brain function.
Sunita Gupta; Alecia G Knight; Shruti Gupta; Pamela E Knapp; Kurt F Hauser; Jeff Keller; Annadora J Bruce-Keller
HIV-Tat elicits microglial glutamate release: role of NAPDH oxidase and the cystine-glutamate antiporter.

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All Publications

2013: Dana M Niedowicz; Thomas L Platt; Christa M Studzinski; Adam M Weidner; Tina L Beckett; Annadora J Bruce-Keller; Jeff Keller; Kristen N Kingry; M Paul Murphy
Leptin regulates amyloid β production via the γ-secretase complex.
Biochimica et biophysica acta 2013;1832(3):439-44.
2013: Linnea R Freeman; Anand Nair; Le Zhang; Annadora J Bruce-Keller; Kalavathi Dasuri; Sun-Ok Fernandez-Kim; Joseph Francis; Jeff Keller
Obesity increases cerebrocortical reactive oxygen species and impairs brain function.
Free radical biology & medicine 2013;56():226-33.
2010: Sunita Gupta; Alecia G Knight; Shruti Gupta; Pamela E Knapp; Kurt F Hauser; Jeff Keller; Annadora J Bruce-Keller
HIV-Tat elicits microglial glutamate release: role of NAPDH oxidase and the cystine-glutamate antiporter.
Neuroscience letters 2010;485(3):233-6.
2010: Kalavathi Dasuri; Philip J Ebenezer; Le Zhang; Sun Ok Fernandez-Kim; Romina M Uranga; Elena Gavilán; Alessia Di Blasio; Jeff Keller
Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: implications for oxidative stress and insolubility of newly synthesized proteins.
Free radical biology & medicine 2010;49(8):1290-7.
2010: Christopher D Morrison; Paul J Pistell; Donald Ingram; William D Johnson; Ying Liu; Sun Ok Fernandez-Kim; Christy L White; Megan N Purpera; Romina M Uranga; Annadora J Bruce-Keller; Jeff Keller
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling.
Journal of neurochemistry 2010;114(6):1581-9.
2010: Annadora J Bruce-Keller; Christy L White; Sunita Gupta; Alecia G Knight; Paul J Pistell; Donald K Ingram; Christopher D Morrison; Jeff Keller
NOX activity in brain aging: exacerbation by high fat diet.
Free radical biology & medicine 2010;49(1):22-30.
2010: Annadora J Bruce-Keller; Sunita Gupta; Taryn E Parrino; Alecia G Knight; Philip J Ebenezer; Adam M Weidner; Harry LeVine; Jeff Keller; William R Markesbery
NOX activity is increased in mild cognitive impairment.
Antioxidants & redox signaling 2010;12(12):1371-82.
2010: Kalavathi Dasuri; Philip Ebenezer; Le Zhang; Sun Ok Fernandez-Kim; Annadora J Bruce-Keller; William R Markesbery; Jeff Keller
Increased protein hydrophobicity in response to aging and Alzheimer disease.
Free radical biology & medicine 2010;48(10):1330-7.
2010: Paul J Pistell; Christopher D Morrison; Sunita Gupta; Alecia G Knight; Jeff Keller; Donald K Ingram; Annadora J Bruce-Keller
Cognitive impairment following high fat diet consumption is associated with brain inflammation.
Journal of neuroimmunology 2010;219(1-2):25-32.
2010: Philip J Ebenezer; Adam M Weidner; Harry LeVine; William R Markesbery; M Paul Murphy; Le Zhang; Kalavathi Dasuri; Sun Ok Fernandez-Kim; Annadora J Bruce-Keller; Elena Gavilán; Jeff Keller
Neuron specific toxicity of oligomeric amyloid-β: role for JUN-kinase and oxidative stress.
Journal of Alzheimer's disease : JAD 2010;22(3):839-48.
2010: Le Zhang; Philip J Ebenezer; Kalavathi Dasuri; Annadora J Bruce-Keller; Sun Ok Fernandez-Kim; Ying Liu; Jeff Keller
Activation of PERK kinase in neural cells by proteasome inhibitor treatment.
Journal of neurochemistry 2010;112(1):238-45.
2010: Manila Amici; Valentina Cecarini; Massimiliano Cuccioloni; Mauro Angeletti; Simone Barocci; Giacomo Rossi; Evandro Fioretti; Jeff Keller; Anna Maria Eleuteri
Interplay between 20S proteasomes and prion proteins in scrapie disease.
Journal of neuroscience research 2010;88(1):191-201.
2009: Kalavathi Dasuri; Le Zhang; Philip Ebenezer; Ying Liu; Sun Ok Fernandez-Kim; Jeff Keller
Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver.
Mechanisms of ageing and development 2009;130(11-12):777-83.
2009: Le Zhang; Philip J Ebenezer; Kalavathi Dasuri; Annadora J Bruce-Keller; Ying Liu; Jeff Keller
Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival.
Journal of neuroscience research 2009;87(14):3231-8.
2009: Laura Bonfili; Manila Amici; Valentina Cecarini; Massimiliano Cuccioloni; Rosalia Tacconi; Mauro Angeletti; Evandro Fioretti; Jeff Keller; Anna Maria Eleuteri
Wheat sprout extract-induced apoptosis in human cancer cells by proteasomes modulation.
Biochimie 2009;91(9):1131-44.
2009: Christy L White; Paul J Pistell; Megan N Purpera; Sunita Gupta; Sun-Ok Fernandez-Kim; Taylor L Hise; Jeff Keller; Donald Ingram; Christopher D Morrison; Annadora J Bruce-Keller
Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet.
Neurobiology of disease 2009;35(1):3-13.
2009: Annadora J Bruce-Keller; Jeff Keller; Christopher D Morrison
Obesity and vulnerability of the CNS.
Biochimica et biophysica acta 2009;1792(5):395-400.
2009: Jeff Keller
Special issue: Reciprocal interactions between diet, metabolism, and the nervous system. Foreword.
Biochimica et biophysica acta 2009;1792(5):393-4.
2009: Le Zhang; Annadora J Bruce-Keller; Kalavathi Dasuri; Anh Thao Nguyen; Ying Liu; Jeff Keller
Diet-induced metabolic disturbances as modulators of brain homeostasis.
Biochimica et biophysica acta 2009;1792(5):417-22.
2009: PETER NELSON; Charles D Smith; Erin A Abner; Frederick A Schmitt; Stephen W Scheff; Gregory J Davis; Jeff Keller; Gregory A Jicha; Daron Davis; Wang Wang-Xia; Adria Hartman; Douglas G Katz; William R Markesbery
Human cerebral neuropathology of Type 2 diabetes mellitus.
Biochimica et biophysica acta 2009;1792(5):454-69.
2009: Christa M Studzinski; Feng Li; Annadora J Bruce-Keller; Sun Ok Fernandez-Kim; Le Zhang; Adam M Weidner; William R Markesbery; Michael Murphy; Jeff Keller
Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.
Journal of neurochemistry 2009;108(4):860-6.
2009: Jadwiga Turchan-Cholewo; Vanessa M Dimayuga; Sunita Gupta; R M Charlotte Gorospe; Jeff Keller; Annadora J Bruce-Keller
NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat.
Antioxidants & redox signaling 2009;11(2):193-204.
2009: Jadwiga Turchan-Cholewo; Filomena O Dimayuga; Sunita Gupta; Jeff Keller; Pamela E Knapp; Kurt F Hauser; Annadora J Bruce-Keller
Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation.
Journal of neurochemistry 2009;108(1):202-15.
2009: Kalavathi Dasuri; Anhthao Nguyen; Le Zhang; Ok Sun Fernandez-Kim; Annadora J Bruce-Keller; Bradford A Blalock; Rafael De Cabo; Jeff Keller
Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction.
Free radical research 2009;43(1):28-36.
2008: Mubeen Ahmad Ansari; Jeff Keller; Stephen W Scheff
Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity.
Free radical biology & medicine 2008;45(11):1510-9.
2008: Laura Bonfili; Valentina Cecarini; Manila Amici; Massimiliano Cuccioloni; Mauro Angeletti; Jeff Keller; Anna Maria Eleuteri
Natural polyphenols as proteasome modulators and their role as anti-cancer compounds.
The FEBS journal 2008;275(22):5512-26.
2008: Feng Li; Le Zhang; Jeffrey Craddock; Annadora J Bruce-Keller; Kalavathi Dasuri; AnhThao Nguyen; Jeff Keller
Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart.
Mechanisms of ageing and development 2008;129(9):515-21.
2008: Jadwiga Turchan-Cholewo; Filomena O Dimayuga; Qunxing Ding; Jeff Keller; Kurt F Hauser; Pamela E Knapp; Annadora J Bruce-Keller
Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia.
Journal of neuroscience research 2008;86(9):2100-10.
2008: Valentina Cecarini; Laura Bonfili; Manila Amici; Mauro Angeletti; Jeff Keller; Anna Maria Eleuteri
Amyloid peptides in different assembly states and related effects on isolated and cellular proteasomes.
Brain research 2008;1209():8-18.
2007: Le Zhang; Feng Li; Edgardo Dimayuga; Jeffrey Craddock; Jeff Keller
Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen.
FEBS letters 2007;581(28):5543-7.
2007: Michael Murphy; Tina L Beckett; Qunxing Ding; Ela Patel; William R Markesbery; Daret K St Clair; Harry LeVine; Jeff Keller
Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice.
Neurobiology of disease 2007;27(3):301-11.
2007: Qunxing Ding; Edgardo Dimayuga; Jeff Keller
Oxidative stress alters neuronal RNA- and protein-synthesis: Implications for neural viability.
Free radical research 2007;41(8):903-10.
2007: PETER NELSON; Jeff Keller
RNA in brain disease: no longer just "the messenger in the middle".
Journal of neuropathology and experimental neurology 2007;66(6):461-8.
2007: Valentina Cecarini; Qunxing Ding; Jeff Keller
Oxidative inactivation of the proteasome in Alzheimer's disease.
Free radical research 2007;41(6):673-80.
2007: D Allan Butterfield; Tanea T Reed; Marzia Perluigi; Carlo De Marco; Raffaella Coccia; Jeff Keller; William R Markesbery; Rukhsana Sultana
Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease.
Brain research 2007;1148():243-8.
2007: Qunxing Ding; Edgardo Dimayuga; Jeff Keller
Oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease.
Current Alzheimer research 2007;4(1):73-9.
2007: Valentina Cecarini; Jillian Gee; Evandro Fioretti; Manila Amici; Mauro Angeletti; Anna Maria Eleuteri; Jeff Keller
Protein oxidation and cellular homeostasis: Emphasis on metabolism.
Biochimica et biophysica acta 2007;1773(2):93-104.
2007: Qunxing Ding; Valentina Cecarini; Jeff Keller
Interplay between protein synthesis and degradation in the CNS: physiological and pathological implications.
Trends in neurosciences 2007;30(1):31-6.
2006: Qunxing Ding; Edgardo Dimayuga; William R Markesbery; Jeff Keller
Proteasome inhibition induces reversible impairments in protein synthesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1055-63.
2006: Qunxing Ding; William R Markesbery; Valentina Cecarini; Jeff Keller
Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease.
Neurochemical research 2006;31(5):705-10.
2006: Muthuswamy Anantharaman; Jitbanjong Tangpong; Jeff Keller; Michael Murphy; William R Markesbery; Kinsley K Kiningham; Daret K St Clair
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
The American journal of pathology 2006;168(5):1608-18.
2006: D Allan Butterfield; H Fai Poon; Daret St Clair; Jeff Keller; William M Pierce; Klein Jon; William R Markesbery
Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease.
Neurobiology of disease 2006;22(2):223-32.
2006: Jillian R Gee; Qunxing Ding; Jeff Keller
Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain.
Biogerontology 2006;7(2):69-79.
2006: Hafiz Mohmmad-Abdul; Rukhsana Sultana; Jeff Keller; Daret K St Clair; William R Markesbery; D Allan Butterfield
Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
Journal of neurochemistry 2006;96(5):1322-35.
2006: Jeff Keller
Age-related neuropathology, cognitive decline, and Alzheimer's disease.
Ageing research reviews 2006;5(1):1-13.
2006: Jeff Keller
Interplay between oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease.
Journal of biomedicine & biotechnology 2006;2006(3):12129.
2006: Qunxing Ding; Edgardo Dimayuga; Jeff Keller
Proteasome regulation of oxidative stress in aging and age-related diseases of the CNS.
Antioxidants & redox signaling 2006;8(1-2):163-72.
2006: Qunxing Ding; Sarah Martin; Edgardo Dimayuga; Annadora J Bruce-Keller; Jeff Keller
LMP2 knock-out mice have reduced proteasome activities and increased levels of oxidatively damaged proteins.
Antioxidants & redox signaling 2006;8(1-2):130-5.
2006: Jeff Keller
The many nuances of oxidative stress and proteolysis.
Antioxidants & redox signaling 2006;8(1-2):119-20.
2006: Qinghua Chen; Jeffrey Thorpe; Jürgen R Dohmen; Feng Li; Jeff Keller
Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome?
Free radical biology & medicine 2006;40(1):120-6.
2005: Qunxing Ding; Jeff Keller
Evaluation of rage isoforms, ligands, and signaling in the brain.
Biochimica et biophysica acta 2005;1746(1):18-27.
2005: Qunxing Ding; William R Markesbery; Qinghua Chen; Feng Li; Jeff Keller
Ribosome dysfunction is an early event in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(40):9171-5.
2005: Qinghua Chen; Jeffrey Thorpe; Jeff Keller
Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability.
The Journal of biological chemistry 2005;280(34):30009-17.
2005: Jillian R Gee; Jeff Keller
Astrocytes: regulation of brain homeostasis via apolipoprotein E.
The international journal of biochemistry & cell biology 2005;37(6):1145-50.
2005: Jillian R Gee; Qunxing Ding; Jeff Keller
Modulation of apolipoprotein E and interleukin-1beta in the aging liver.
Experimental gerontology 2005;40(5):409-15.
2005: Jeff Keller; Frederick A Schmitt; S W Scheff; Qunxing Ding; Q Chen; D Allan Butterfield; William R Markesbery
Evidence of increased oxidative damage in subjects with mild cognitive impairment.
Neurology 2005;64(7):1152-6.
2005: Rebecca R Smith; Edgardo Dimayuga; Jeff Keller; William F Maragos
Enhanced toxicity to the catecholamine tyramine in polyglutamine transfected SH-SY5Y cells.
Neurochemical research 2005;30(4):527-31.
2005: Filomena O Dimayuga; Janelle L Reed; Genevieve A Carnero; Chunmei Wang; Edgardo Dimayuga; Vanessa M Dimayuga; Andrea Perger; Melinda E Wilson; Jeff Keller; Annadora J Bruce-Keller
Estrogen and brain inflammation: effects on microglial expression of MHC, costimulatory molecules and cytokines.
Journal of neuroimmunology 2005;161(1-2):123-36.
2005: Maile R Brown; Vimala Bondada; Jeff Keller; Jeffery Thorpe; James W Geddes
Proteasome or calpain inhibition does not alter cellular tau levels in neuroblastoma cells or primary neurons.
Journal of Alzheimer's disease : JAD 2005;7(1):15-24.
2005: Qinghua Chen; Qunxing Ding; Jeffrey Thorpe; R Jürgen Dohmen; Jeff Keller
RNA interference toward UMP1 induces proteasome inhibition in Saccharomyces cerevisiae: evidence for protein oxidation and autophagic cell death.
Free radical biology & medicine 2005;38(2):226-34.
2005: Qunxing Ding; Jeff Keller
Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain.
Neuroscience letters 2005;373(1):67-72.
2005: Quinghua Chen; Qunxing Ding; Jeff Keller
The stationary phase model of aging in yeast for the study of oxidative stress and age-related neurodegeneration.
Biogerontology 2005;6(1):1-13.
2004: Qunxing Ding; Edgardo Dimayuga; William R Markesbery; Jeff Keller
Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures.
Journal of neurochemistry 2004;91(5):1211-8.
2004: Jeff Keller; Edgardo Dimayuga; Qinghua Chen; Jeffrey Thorpe; Jillian Gee; Qunxing Ding
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.
The international journal of biochemistry & cell biology 2004;36(12):2376-91.
2004: Qinghua Chen; Jeffrey Thorpe; Qunxing Ding; Ismail S El-Amouri; Jeff Keller
Proteasome synthesis and assembly are required for survival during stationary phase.
Free radical biology & medicine 2004;37(6):859-68.
2004: Janelle L Reed; Filomena O Dimayuga; Laurie M Davies; Jeff Keller; Annadora J Bruce-Keller
Estrogen increases proteasome activity in murine microglial cells.
Neuroscience letters 2004;367(1):60-5.
2004: Patrick G Sullivan; Alexander G Rabchevsky; Jeff Keller; Mark A Lovell; Ajeet Sodhi; Ronald P Hart; Stephen W Scheff
Intrinsic differences in brain and spinal cord mitochondria: Implication for therapeutic interventions.
The Journal of comparative neurology 2004;474(4):524-34.
2004: Patrick G Sullivan; Natasha B Dragicevic; Jian-Hong Deng; Yidong Bai; Edgardo Dimayuga; Qunxing Ding; Qinghua Chen; Annadora J Bruce-Keller; Jeff Keller
Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover.
The Journal of biological chemistry 2004;279(20):20699-707.
2004: Rukhsana Sultana; Shelley Newman; Hafiz Mohmmad-Abdul; Jeff Keller; D Allan Butterfield
Protective effect of the xanthate, D609, on Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress in primary neuronal cells.
Free radical research 2004;38(5):449-58.
2004: Sarah Martin; Jillian R Gee; Annadora J Bruce-Keller; Jeff Keller
Loss of an individual proteasome subunit alters motor function but not cognitive function or ambulation in mice.
Neuroscience letters 2004;357(1):76-8.
2004: Jennifer Drake; Robin Petroze; Alessandra Castegna; Qunxing Ding; Jeff Keller; William R Markesbery; Mark A Lovell; D Allan Butterfield
4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease.
Neuroscience letters 2004;356(3):155-8.
2004: Qunxing Ding; Annadora J Bruce-Keller; Qinghua Chen; Jeff Keller
Analysis of gene expression in neural cells subject to chronic proteasome inhibition.
Free radical biology & medicine 2004;36(4):445-55.
2003: Annadora J Bruce-Keller; Ashok Chauhan; Filomena O Dimayuga; Jillian Gee; Jeff Keller; Avindra Nath
Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(23):8417-22.
2003: Qunxing Ding; Kristi Reinacker; Edgardo Dimayuga; Vidya Nukala; Jennifer Drake; D Allan Butterfield; Jay Dunn; Sarah Martin; Annadora J Bruce-Keller; Jeff Keller
Role of the proteasome in protein oxidation and neural viability following low-level oxidative stress.
FEBS letters 2003;546(2-3):228-32.
2003: Qunxing Ding; Edgardo Dimayuga; Sarah Martin; Annadora J Bruce-Keller; Vidya Nukala; Ana Maria Cuervo; Jeff Keller
Characterization of chronic low-level proteasome inhibition on neural homeostasis.
Journal of neurochemistry 2003;86(2):489-97.
2003: Qunxing Ding; Jeff Keller
Does proteasome inhibition play a role in mediating neuropathology and neuron death in Alzheimer's disease?
Journal of Alzheimer's disease : JAD 2003;5(3):241-5.
2003: Filomena O Dimayuga; Qunxing Ding; Jeff Keller; Mark A Marchionni; Kim B Seroogy; Annadora J Bruce-Keller
The neuregulin GGF2 attenuates free radical release from activated microglial cells.
Journal of neuroimmunology 2003;136(1-2):67-74.
2002: Patrick G Sullivan; Jeff Keller; Wendy L Bussen; Stephen W Scheff
Cytochrome c release and caspase activation after traumatic brain injury.
Brain research 2002;949(1-2):88-96.
2002: Jillian Gee; Quxing Ding; Jeff Keller
Analysis of Werner's expression within the brain and primary neuronal culture.
Brain research 2002;940(1-2):44-8.
2002: Qunxing Ding; Jennifer J Lewis; Kenneth M Strum; Edgardo Dimayuga; Annadora J Bruce-Keller; Jay Dunn; Jeff Keller
Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival.
The Journal of biological chemistry 2002;277(16):13935-42.
2002: Jeff Keller; Jillian Gee; Qunxing Ding
The proteasome in brain aging.
Ageing research reviews 2002;1(2):279-93.
2001: Annadora J Bruce-Keller; Steven W Barger; N I Moss; J T Pham; Jeff Keller; Avindra Nath
Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17 beta-estradiol.
Journal of neurochemistry 2001;78(6):1315-24.
2001: Qunxing Ding; Jeff Keller
Proteasomes and proteasome inhibition in the central nervous system.
Free radical biology & medicine 2001;31(5):574-84.
2001: Christopher M Lauderback; Janna M Hackett; FF Huang; Jeff Keller; Luke I Szweda; William R Markesbery; D Allan Butterfield
The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42.
Journal of neurochemistry 2001;78(2):413-6.
2001: Qunxing Ding; Jeff Keller
Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins.
Journal of neurochemistry 2001;77(4):1010-7.
2001: Christopher M Lauderback; Janna M Hackett; Jeff Keller; Sridhar Varadarajan; Luke I Szweda; Mark S Kindy; William R Markesbery; D Allan Butterfield
Vulnerability of synaptosomes from apoE knock-out mice to structural and oxidative modifications induced by A beta(1-40): implications for Alzheimer's disease.
Biochemistry 2001;40(8):2548-54.
2000: Jeff Keller; FF Huang; Edgardo Dimayuga; William F Maragos
Dopamine induces proteasome inhibition in neural PC12 cell line.
Free radical biology & medicine 2000;29(10):1037-42.
2000: Jeff Keller; FF Huang; H Zhu; J Yu; Ye-Shih Ho; T S Kindy
Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(10):1467-73.
2000: Annadora J Bruce-Keller; J L Keeling; Jeff Keller; FF Huang; S Camondola; Mark P Mattson
Antiinflammatory effects of estrogen on microglial activation.
Endocrinology 2000;141(10):3646-56.
2000: Jeff Keller; William R Markesbery
Proteasome inhibition results in increased poly-ADP-ribosylation: implications for neuron death.
Journal of neuroscience research 2000;61(4):436-42.
2000: Jeff Keller; KB Hanni; William R Markesbery
Impaired proteasome function in Alzheimer's disease.
Journal of neurochemistry 2000;75(1):436-9.
2000: Marion R Steiner; Frederick W Holtsberg; Jeff Keller; Mark P Mattson; Sheldon M Steiner
Lysophosphatidic acid induction of neuronal apoptosis and necrosis.
Annals of the New York Academy of Sciences 2000;905():132-41.
2000: Jeff Keller; Christopher M Lauderback; D Allan Butterfield; Mark S Kindy; J Yu; William R Markesbery
Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice.
Journal of neurochemistry 2000;74(4):1579-86.
2000: Jeff Keller; KB Hanni; Mark S Kindy
Oxidized high-density lipoprotein induces neuron death.
Experimental neurology 2000;161(2):621-30.
2000: Jeff Keller; KB Hanni; William R Markesbery
Possible involvement of proteasome inhibition in aging: implications for oxidative stress.
Mechanisms of ageing and development 2000;113(1):61-70.
2000: Jeff Keller; FF Huang; William R Markesbery
Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
Neuroscience 2000;98(1):149-56.
1999: Jeff Keller; KB Hanni; William R Markesbery
4-hydroxynonenal increases neuronal susceptibility to oxidative stress.
Journal of neuroscience research 1999;58(6):823-30.
1999: M Tolar; Jeff Keller; S Chan; Mark P Mattson; Marcos A Marques; keith crutcher
Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(16):7100-10.
1999: Jeff Keller; KB Hanni; William R Markesbery
Oxidized low-density lipoprotein induces neuronal death: implications for calcium, reactive oxygen species, and caspases.
Journal of neurochemistry 1999;72(6):2601-9.
1999: Jeff Keller; KB Hanni; S Prasad Gabbita; V Friebe; Mark P Mattson; Mark S Kindy
Oxidized lipoproteins increase reactive oxygen species formation in microglia and astrocyte cell lines.
Brain research 1999;830(1):10-5.
1999: Jeff Keller; KB Hanni; Ward Anthony Pedersen; Neil R Cashman; Mark P Mattson; S Prasad Gabbita; V Friebe; William R Markesbery
Opposing actions of native and oxidized lipoprotein on motor neuron-like cells.
Experimental neurology 1999;157(1):202-10.
1999: Annadora J Bruce-Keller; James W Geddes; Pamela E Knapp; R W McFall; Jeff Keller; Frederick W Holtsberg; S Parthasarathy; Sheldon M Steiner; Mark P Mattson
Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD.
Journal of neuroimmunology 1999;93(1-2):53-71.
1998: Jeff Keller; KB Hanni; Mark P Mattson; William R Markesbery
Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity.
Neuroreport 1998;9(16):3731-4.
1998: Ward Anthony Pedersen; W Fu; Jeff Keller; William R Markesbery; S Appel; R G Smith; Edward J Kasarskis; Mark P Mattson
Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients.
Annals of neurology 1998;44(5):819-24.
1998: Patrick G Sullivan; Jeff Keller; Mark P Mattson; Stephen W Scheff
Traumatic brain injury alters synaptic homeostasis: implications for impaired mitochondrial and transport function.
Journal of neurotrauma 1998;15(10):789-98.
1998: Frederick W Holtsberg; Marion R Steiner; Annadora J Bruce-Keller; Jeff Keller; Mark P Mattson; J C Moyers; Sheldon M Steiner
Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells.
Journal of neuroscience research 1998;53(6):685-96.
1998: Jim G Begley; D Allan Butterfield; Jeff Keller; T Koppal; Jennifer Drake; Mark P Mattson
Cryopreservation of rat cortical synaptosomes and analysis of glucose and glutamate transporter activities, and mitochondrial function.
Brain research. Brain research protocols 1998;3(1):76-82.
1998: Mark P Mattson; Jeff Keller; Jim G Begley
Evidence for synaptic apoptosis.
Experimental neurology 1998;153(1):35-48.
1998: Jeff Keller; Qing Guo; Frederick W Holtsberg; Annadora J Bruce-Keller; Mark P Mattson
Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(12):4439-50.
1998: E M Blanc; Jeff Keller; S Fernandez; Mark P Mattson
4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes.
Glia 1998;22(2):149-60.
1998: Jeff Keller; Mark S Kindy; Frederick W Holtsberg; Daret K St Clair; Hsiu-Chuan Yen; A Germeyer; Sheldon M Steiner; Annadora J Bruce-Keller; J B Hutchins; Mark P Mattson
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(2):687-97.
1998: Jeff Keller; Mark P Mattson
Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system.
Reviews in the neurosciences 1998;9(2):105-16.
1998: Frederick W Holtsberg; Marion R Steiner; Jeff Keller; RJ Mark; Mark P Mattson; Sheldon M Steiner
Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons.
Journal of neurochemistry 1998;70(1):66-76.
1997: Jeff Keller; A Germeyer; Jim G Begley; Mark P Mattson
17Beta-estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron.
Journal of neuroscience research 1997;50(4):522-30.
1997: Jeff Keller; RJ Mark; AJ Bruce; EM Blanc; Jeffrey rothstein; K Uchida; G Waeg; Mark P Mattson
4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes.
Neuroscience 1997;80(3):685-96.
1997: R Subramaniam; F Roediger; B Jordan; Mark P Mattson; Jeff Keller; G Waeg; D Allan Butterfield
The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins.
Journal of neurochemistry 1997;69(3):1161-9.
1997: Jeff Keller; Marion R Steiner; Frederick W Holtsberg; Mark P Mattson; Sheldon M Steiner
Lysophosphatidic acid-induced proliferation-related signals in astrocytes.
Journal of neurochemistry 1997;69(3):1073-84.
1997: A Ishida; K Furukawa; Jeff Keller; Mark P Mattson
Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices.
Neuroreport 1997;8(9-10):2133-7.
1997: Jeff Keller; Zhen Pang; James W Geddes; Jim G Begley; A Germeyer; G Waeg; Mark P Mattson
Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal.
Journal of neurochemistry 1997;69(1):273-84.
1997: Frederick W Holtsberg; Marion R Steiner; K Furukawa; Jeff Keller; Mark P Mattson; Sheldon M Steiner
Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium.
Journal of neurochemistry 1997;69(1):68-75.
1997: RJ Mark; Jeff Keller; Inna I Kruman; Mark P Mattson
Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons.
Brain research 1997;756(1-2):205-14.
1997: James W Geddes; Kanagasabai Panchalingam; Jeff Keller; Jay W Pettegrew
Elevated phosphocholine and phosphatidylcholine following rat entorhinal cortex lesions.
Neurobiology of aging 1997;18(3):305-8.
1996: Jeff Keller; Marion R Steiner; Mark P Mattson; Sheldon M Steiner
Lysophosphatidic acid decreases glutamate and glucose uptake by astrocytes.
Journal of neurochemistry 1996;67(6):2300-5.
1995: Mark P Mattson; B Cheng; S A Baldwin; V L Smith-Swintosky; Jeff Keller; James W Geddes; Stephen W Scheff; Sylvia Christakos
Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response.
Journal of neuroscience research 1995;42(3):357-70.
1994: James W Geddes; Vimala Bondada; Jeff Keller
Effects of intrahippocampal colchicine administration on the levels and localization of microtubule-associated proteins, tau and MAP2.
Brain research 1994;633(1-2):1-8.