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Brian Thomas

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Jenny L Wiley; Yanan Zhang; Alan Fulp; Rangan Maitra; Julie A Marusich; Brian Thomas; Anu Mahadevan
Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice.
David A Perrey; Brian P Gilmour; Scott P Runyon; Brian Thomas; Yanan Zhang
Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.
Yanan Zhang; Anne F Gilliam; Rangan Maitra; M Imad Damaj; Julianne M Tajuba; Herbert H Seltzman; Brian Thomas
Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.

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All Publications

2012: Jenny L Wiley; Yanan Zhang; Alan Fulp; Rangan Maitra; Julie A Marusich; Brian Thomas; Anu Mahadevan
Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice.
European journal of pharmacology 2012;695(1-3):62-70.
2011: David A Perrey; Brian P Gilmour; Scott P Runyon; Brian Thomas; Yanan Zhang
Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2011;21(10):2980-5.
2010: Yanan Zhang; Anne F Gilliam; Rangan Maitra; M Imad Damaj; Julianne M Tajuba; Herbert H Seltzman; Brian Thomas
Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.
Journal of medicinal chemistry 2010;53(19):7048-60.
2010: D Matthew Walentiny; Robert Vann; Jonathan A Warner; Lindsey S King; Herbert H Seltzman; Hernán A Navarro; Charles E Twine; Brian Thomas; Anne F Gilliam; Brian P Gilmour; F Ivy Carroll; Jenny L Wiley
Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents.
Psychopharmacology 2010;210(2):275-84.
2010: Matthew O Lindeblad; Kenneth S. Bauer; Alexander Zakharov; Judith M Hill; Jonathan S Green; Brian Thomas; Arthur Schwartz; Izet M Kapetanovic; Aleksander V. Lyubimov
Pharmacokinetic and tissue distribution study of [14C]fluasterone in male Beagle dogs following intravenous, oral and subcutaneous dosing routes.
Chemico-biological interactions 2010;183(2):317-26.
2009: Jason P Burgess; Jonathan S Green; Judith M Hill; Qiao Zhan; Matthew Lindeblad; Aleksander V. Lyubimov; Izet M Kapetanovic; Arthur Schwartz; Brian Thomas
Identification of [14C]fluasterone metabolites in urine and feces collected from dogs after subcutaneous and oral administration of [14C]fluasterone.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(5):1089-97.
2009: Patrick M Beardsley; Brian Thomas; Lance McMahon
Cannabinoid CB1 receptor antagonists as potential pharmacotherapies for drug abuse disorders.
International review of psychiatry (Abingdon, England) 2009;21(2):134-42.
2008: Yanan Zhang; Jason P Burgess; Marcus Brackeen; Anne F Gilliam; Wayne Mascarella; Kevin Page; Herbert H Seltzman; Brian Thomas
Conformationally constrained analogues of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): design, synthesis, computational analysis, and biological evaluations.
Journal of medicinal chemistry 2008;51(12):3526-39.
2007: Caryl Bourne; Sucharita Roy; Jenny L Wiley; Billy R Martin; Brian Thomas; Anu Mahadevan; Raj K Razdan
Novel, potent THC/anandamide (hybrid) analogs.
Bioorganic & medicinal chemistry 2007;15(24):7850-64.
2007: Vaughan Rees; Geoffrey Ferris Wayne; Brian Thomas; Gregory N Connolly
Physical design analysis and mainstream smoke constituent yields of the new potential reduced exposure product, Marlboro UltraSmooth.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2007;9(11):1197-206.
2006: Jason P Burgess; James S Wintermute; Brian Thomas; Izet M Kapetanovic
Complete 1H and 13C assignments of fluorinated analogs of dehydroepiandrosterone.
Magnetic resonance in chemistry : MRC 2006;44(11):1051-3.
2006: Mary F Paine; Wilbur W Widmer; Heather L Hart; Susan N Pusek; Kimberly L Beavers; Anne B Criss; Sherri S Brown; Brian Thomas; Paul B Watkins
A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction.
The American journal of clinical nutrition 2006;83(5):1097-105.
2006: Brian Thomas; Yanan Zhang; Marcus Brackeen; Kevin M Page; Wayne Mascarella; Herbert H Seltzman
Conformational characteristics of the interaction of SR141716A with the CB1 cannabinoid receptor as determined through the use of conformationally constrained analogs.
The AAPS journal 2006;8(4):E665-71.
2005: Brian Thomas; Maria Elena Y Francisco; Herbert H Seltzman; James B Thomas; Scott E Fix; Anne-Kathrin Schulz; Anne F Gilliam; Roger G Pertwee; Lesley A Stevenson
Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities.
Bioorganic & medicinal chemistry 2005;13(18):5463-74.
2005: Patrick M Beardsley; Brian Thomas
Current evidence supporting a role of cannabinoid CB1 receptor (CB1R) antagonists as potential pharmacotherapies for drug abuse disorders.
Behavioural pharmacology 2005;16(5-6):275-96.
2005: Stephen A Varvel; D Troy Bridgen; Qing Tao; Brian Thomas; Billy R Martin; Aron H Lichtman
Delta9-tetrahydrocannbinol accounts for the antinociceptive, hypothermic, and cataleptic effects of marijuana in mice.
The Journal of pharmacology and experimental therapeutics 2005;314(1):329-37.
2003: John W Huffman; John R A Miller; John Liddle; Shu Yu; Brian Thomas; Jenny L Wiley; Billy R Martin
Structure-activity relationships for 1',1'-dimethylalkyl-Delta8-tetrahydrocannabinols.
Bioorganic & medicinal chemistry 2003;11(7):1397-410.
2003: Patricia A Hunt; Kara E Koehler; Martha Susiarjo; Craig A Hodges; Arlene Ilagan; Robert C Voigt; Sally Thomas; Brian Thomas; Terry J Hassold
Bisphenol a exposure causes meiotic aneuploidy in the female mouse.
Current biology : CB 2003;13(7):546-53.
2002: LeAnne T Bloedon; A Robert Jeffcoat; Wlodek Lopaczynski; Michael J Schell; Tracy M Black; Kelly J Dix; Brian Thomas; Craig D Albright; Marjorie G Busby; James A Crowell; Steven H Zeisel
Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women.
The American journal of clinical nutrition 2002;76(5):1126-37.
2002: Rochelle W Tyl; Christina B Myers; Melissa C Marr; Brian Thomas; A R Keimowitz; Dolores R Brine; M M Veselica; Patricia A Fail; T Y Chang; John C Seely; Ronald L Joiner; John H Butala; SS Dimond; SZ Cagen; RN Shiotsuka; G D Stropp; John M Waechter
Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):121-46.
2002: Maria Elena Y Francisco; Herbert H Seltzman; Anne F Gilliam; René A Mitchell; Sharyl L Rider; Roger G Pertwee; Lesley A Stevenson; Brian Thomas
Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716).
Journal of medicinal chemistry 2002;45(13):2708-19.
2002: Billy R Martin; Reneé G Jefferson; Ramona Winckler; Jenny L Wiley; Brian Thomas; Peter J Crocker; William Williams; Raj K Razdan
Assessment of structural commonality between tetrahydrocannabinol and anandamide.
European journal of pharmacology 2002;435(1):35-42.
2002: Marjorie G Busby; A Robert Jeffcoat; LeAnne T Bloedon; Matthew A Koch; Tracy Black; Kelly J Dix; William D Heizer; Brian Thomas; Judith M Hill; James A Crowell; Steven H Zeisel
Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men.
The American journal of clinical nutrition 2002;75(1):126-36.
2001: Brian Thomas; Steven H Zeisel; Marjorie G Busby; J M Hill; R A Mitchell; Nicole Scheffler; S S Brown; L T Bloeden; Kelly J Dix; A Robert Jeffcoat
Quantitative analysis of the principle soy isoflavones genistein, daidzein and glycitein, and their primary conjugated metabolites in human plasma and urine using reversed-phase high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Biomedical sciences and applications 2001;760(2):191-205.
2001: Kelly J Dix; Donna P Coleman; J E Fossett; N F Gaudette; A P Stanley; Brian Thomas; A Robert Jeffcoat
Disposition of propargyl alcohol in rat and mouse after intravenous, oral, dermal and inhalation exposure.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(6):357-75.
2001: KS De Costa; Sherry R Black; Brian Thomas; Jason P Burgess; James M Mathews
Metabolism and disposition of alpha-methylstyrene in rats.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(2):166-71.
2000: A R Keimowitz; Billy R Martin; Raj K Razdan; Peter J Crocker; Wayne Mascarella; Brian Thomas
QSAR analysis of Delta(8)-THC analogues: relationship of side-chain conformation to cannabinoid receptor affinity and pharmacological potency.
Journal of medicinal chemistry 2000;43(1):59-70.
1999: B P Bowman; S R Vaughan; Q David Walker; S L Davis; PJ Little; Nicole Scheffler; Brian Thomas; Cynthia M Kuhn
Effects of sex and gonadectomy on cocaine metabolism in the rat.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1316-23.
1999: L A Buckley; Donna P Coleman; Jason P Burgess; Brian Thomas; Leo T Burka; A Robert Jeffcoat
Identification of urinary metabolites of isoprene in rats and comparison with mouse urinary metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(7):848-54.
1999: Brian Thomas; Jason P Burgess; Donna P Coleman; Nicole Scheffler; A Robert Jeffcoat; Kelly J Dix
Isolation and identification of novel metabolites of gemfibrozil in rat urine.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(1):147-57.
1998: Patricia H Reggio; S Basu-Dutt; Judy Barnett-Norris; M T Castro; Dow P Hurst; Herbert H Seltzman; Michael Roche; Anne F Gilliam; Brian Thomas; Lesley A Stevenson; Roger G Pertwee; Mary E Abood
The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.
Journal of medicinal chemistry 1998;41(26):5177-87.
1998: Brian Thomas; Anne F Gilliam; D F Burch; Michael Roche; Herbert H Seltzman
Comparative receptor binding analyses of cannabinoid agonists and antagonists.
The Journal of pharmacology and experimental therapeutics 1998;285(1):285-92.
1997: Herbert H Seltzman; Denise N Fleming; Brian Thomas; Anne F Gilliam; D S McCallion; Roger G Pertwee; DR Compton; Billy R Martin
Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide.
Journal of medicinal chemistry 1997;40(22):3626-34.
1997: Aloke Dutta; W Ryan; Brian Thomas; M Singer; DR Compton; Billy R Martin; Raj K Razdan
Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs).
Bioorganic & medicinal chemistry 1997;5(8):1591-600.
1996: James M Mathews; K deCosta; Brian Thomas
Lauramide diethanolamine absorption, metabolism, and disposition in rats and mice after oral, intravenous, and dermal administration.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(7):702-10.
1996: John R Lever; Ursula Scheffel; M Stathis; Herbert H Seltzman; C D Wyrick; Philip Abraham; K Parham; Brian Thomas; J W Boja; Michael J Kuhar; Frank carroll
Synthesis and in vivo studies of a selective ligand for the dopamine transporter: 3 beta-(4-[125I]iodophenyl) tropan-2 beta-carboxylic acid isopropyl ester ([125I]RTI-121).
Nuclear medicine and biology 1996;23(3):277-84.
1996: F R Ley; A Robert Jeffcoat; Brian Thomas
Determination of ibogaine in plasma by gas chromatography--chemical ionization mass spectrometry.
Journal of chromatography. A 1996;723(1):101-9.
1996: Brian Thomas; I B Adams; Wayne Mascarella; Billy R Martin; Raj K Razdan
Structure-activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore.
Journal of medicinal chemistry 1996;39(2):471-9.
1995: I B Adams; W Ryan; M Singer; Brian Thomas; DR Compton; Raj K Razdan; Billy R Martin
Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs.
The Journal of pharmacology and experimental therapeutics 1995;273(3):1172-81.
1994: Brian Thomas; A Robert Jeffcoat; M W Myers; James M Mathews; C E Cook
Determination of l-alpha-acetylmethadol, l-alpha-noracetylmethadol and l-alpha-dinoracetylmethadol in plasma by gas chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical applications 1994;655(2):201-11.
1992: Brian Thomas; X Wei; Billy R Martin
Characterization and autoradiographic localization of the cannabinoid binding site in rat brain using [3H]11-OH-delta 9-THC-DMH.
The Journal of pharmacology and experimental therapeutics 1992;263(3):1383-90.
1991: Brian Thomas; DR Compton; Billy R Martin; S F Semus
Modeling the cannabinoid receptor: a three-dimensional quantitative structure-activity analysis.
Molecular pharmacology 1991;40(5):656-65.
1991: Billy R Martin; DR Compton; Brian Thomas; W R Prescott; P J Little; Raj K Razdan; M R Johnson; L S Melvin; Urij Rampampam; S J Ward
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs.
Pharmacology, biochemistry, and behavior 1991;40(3):471-8.
1990: Brian Thomas; DR Compton; Billy R Martin
Characterization of the lipophilicity of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency.
The Journal of pharmacology and experimental therapeutics 1990;255(2):624-30.
1990: Brian Thomas; Billy R Martin
In vitro metabolism of (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol, a synthetic bicyclic cannabinoid analog.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(6):1046-54.
1989: Brian Thomas; Billy R Martin
Identification of metabolites of CP-55,940 formed in-vitro by mouse livers.
NIDA research monograph 1989;95():287-8.
1988: Brian Thomas; Edward R Bowman; S M Tucker; Mario D Aceto
Plasma concentrations of nicotine in rats during tolerance and chronic exposure studies.
European journal of drug metabolism and pharmacokinetics 1988;13(4):247-52.
1988: J E Lyddane; Brian Thomas; DR Compton; Billy R Martin
Modification of phencyclidine intoxification and biodisposition by charcoal and other treatments.
Pharmacology, biochemistry, and behavior 1988;30(2):371-7.
1988: L P Lue; J A Scimeca; Brian Thomas; Billy R Martin
Pyrolytic fate of piperidinocyclohexanecarbonitrile, a contaminant of phencyclidine, during smoking.
Journal of analytical toxicology 1988;12(2):57-61.
1986: Brian Thomas; J E Lyddane; B R Martin
Modification of behavioral effects and biodisposition of phencyclidine in rats by ammonium chloride.
The Journal of pharmacology and experimental therapeutics 1986;239(1):48-54.
1986: L P Lue; J A Scimeca; Brian Thomas; Billy R Martin
Identification and quantification of phencyclidine pyrolysis products formed during smoking.
Journal of analytical toxicology 1986;10(3):81-6.
1985: M L Reynolds; P J Little; Brian Thomas; R B Bagley; B R Martin
Relationship between the biodisposition of [3H]soman and its pharmacological effects in mice.
Toxicology and applied pharmacology 1985;80(3):409-20.