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William C. Mobley

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Alexander M Kleschevnikov; Mehrdad Shamloo; Pavel V Belichenko; Mehrdad Faizi; Khin Htun; Lucia F Jacobs; William C. Mobley
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.
Alexander M Kleschevnikov; Michael T Maloney; Pavel V Belichenko; Jessica Gall; Lizzy George; Rachel Nosheny; Ahmad Salehi; William C. Mobley
Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome.
Mehrdad Faizi; Alexander M Kleschevnikov; William C. Mobley; Matthew Priestley; Nay Saw; Patrick L Bader; Pavel V Belichenko; Angelo Encarnacion; Richard W Tsien; Christine Tun; Mehrdad Shamloo
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.

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2012: Alexander M Kleschevnikov; Mehrdad Shamloo; Pavel V Belichenko; Mehrdad Faizi; Khin Htun; Lucia F Jacobs; William C. Mobley
Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(27):9217-27.
2012: Alexander M Kleschevnikov; Michael T Maloney; Pavel V Belichenko; Jessica Gall; Lizzy George; Rachel Nosheny; Ahmad Salehi; William C. Mobley
Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome.
Neurobiology of disease 2012;45(2):683-91.
2011: Mehrdad Faizi; Alexander M Kleschevnikov; William C. Mobley; Matthew Priestley; Nay Saw; Patrick L Bader; Pavel V Belichenko; Angelo Encarnacion; Richard W Tsien; Christine Tun; Mehrdad Shamloo
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.
Neurobiology of disease 2011;43(2):397-413.
2009: Ahmad Salehi; Mehrdad Faizi; D Colas; Janice S Valletta; J Laguna; R Takimoto-Kimura; Alexander M Kleschevnikov; S L Wagner; P Aisen; Mehrdad Shamloo; William C. Mobley
Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.
Science translational medicine 2009;1(7):7ra17.
2009: Stanley J Tamaki; Yakop Jacobs; Monika Dohse; Alexandra Capela; Jonathan D Cooper; Michael Reitsma; Dongping He; Robert Tushinski; Pavel V Belichenko; Ahmad Salehi; William C. Mobley; Fred H Gage; Stephen Huhn; Ann S Tsukamoto; Irving L Weissman; Nobuko Uchida
Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis.
Cell stem cell 2009;5(3):310-9.
2009: André Mégarbané; Aimé Ravel; Clotilde Mircher; Franck Sturtz; Yann Grattau; Marie-Odile Rethoré; jean maurice delabar; William C. Mobley
The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome.
Genetics in medicine : official journal of the American College of Medical Genetics 2009;11(9):611-6.
2009: Pavel V Belichenko; Elena E Wright; Nadia P Belichenko; Eliezer Masliah; Hong Hua Li; William C. Mobley; Uta Francke
Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks.
The Journal of comparative neurology 2009;514(3):240-58.
2009: Nadia P Belichenko; Pavel V Belichenko; Alexander M Kleschevnikov; Ahmad Salehi; Roger H Reeves; William C. Mobley
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(18):5938-48.
2009: Nadia P Belichenko; Pavel V Belichenko; William C. Mobley
Evidence for both neuronal cell autonomous and nonautonomous effects of methyl-CpG-binding protein 2 in the cerebral cortex of female mice with Mecp2 mutation.
Neurobiology of disease 2009;34(1):71-7.
2009: Chengbiao Wu; Bianxiao Cui; Lingmin He; Liang Chen; William C. Mobley
The coming of age of axonal neurotrophin signaling endosomes.
Journal of proteomics 2009;72(1):46-55.
2009: Mark Benedyk; Lars Berglund; Marc Facciotti; William C. Mobley; Deborah Zucker
Strategies for innovation and interdisciplinary translational research: research and career benefits and barriers.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2009;57(2):477-81.
2009: Pavel V Belichenko; Alexander M Kleschevnikov; Eliezer Masliah; Chengbiao Wu; Ryoko Takimoto-Kimura; Ahmad Salehi; William C. Mobley
Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.
The Journal of comparative neurology 2009;512(4):453-66.
2008: Jun Wan; Anthony Y Cheung; Wing-Yu Fu; Chengbiao Wu; Mingjie Zhang; William C. Mobley; Zelda H Cheung; Nancy Y Ip
Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(36):9002-12.
2008: Nadia P Belichenko; Pavel V Belichenko; Hong Hua Li; William C. Mobley; Uta Francke
Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome.
The Journal of comparative neurology 2008;508(1):184-95.
2008: Damien Colas; Janice S Valletta; Ryoko Takimoto-Kimura; Seiji Nishino; Nobuhiro Fujiki; William C. Mobley; Emmanuel Mignot
Sleep and EEG features in genetic models of Down syndrome.
Neurobiology of disease 2008;30(1):1-7.
2008: Heidi J Chial; Ruping Wu; Carolyn V Ustach; Linda C McPhail; William C. Mobley; Yong Q Chen
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.
Traffic (Copenhagen, Denmark) 2008;9(2):215-29.
2008: David Eaton; Robert B Daroff; Herman Autrup; James Bridges; Patricia Buffler; Lucio G Costa; Joseph Coyle; Guy M McKhann; William C. Mobley; Lynn Nadel; Diether Neubert; Rolf Schulte-Hermann; Peter S Spencer
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.
Critical reviews in toxicology 2008;38 Suppl 2():1-125.
2007: Chengbiao Wu; Alfredo Ramirez; Bianxiao Cui; Jianqing Ding; Jean-Dominique Delcroix; Janice S Valletta; Jia-Jia Liu; Yanmin Yang; Steven Chu; William C. Mobley
A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway.
Traffic (Copenhagen, Denmark) 2007;8(11):1503-20.
2007: Pavel V Belichenko; Alexander M Kleschevnikov; Ahmad Salehi; Charles J Epstein; William C. Mobley
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.
The Journal of comparative neurology 2007;504(4):329-45.
2007: Bianxiao Cui; Chengbiao Wu; Liang Chen; Alfredo Ramirez; Elaine L Bearer; Wei-Ping Li; William C. Mobley; Steven Chu
One at a time, live tracking of NGF axonal transport using quantum dots.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13666-71.
2007: Jia-Jia Liu; Jianqing Ding; Chengbiao Wu; Prasanthi Bhagavatula; Bianxiao Cui; Steve Chu; William C. Mobley; Yanmin Yang
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2223-8.
2007: Ahmad Salehi; Mehrdad Faizi; Pavel V Belichenko; William C. Mobley
Using mouse models to explore genotype-phenotype relationship in Down syndrome.
Mental retardation and developmental disabilities research reviews 2007;13(3):207-14.
2006: Ahmad Salehi; Jean-Dominique Delcroix; Pavel V Belichenko; Ke Zhan; Chengbiao Wu; Janice S Valletta; Ryoko Takimoto-Kimura; Alexander M Kleschevnikov; Kumar Sambamurti; Peter P Chung; Weiming Xia; Angela Villar; William A Campbell; Laura Shapiro Kulnane; Ralph A. Nixon; Bruce Lamb; Charles J Epstein; Gorazd B Stokin; Lawrence S B Goldstein; William C. Mobley
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Neuron 2006;51(1):29-42.
2006: Yuki Miyamoto; Junji Yamauchi; Akito Tanoue; Chengbiao Wu; William C. Mobley
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10444-9.
2006: G Watson; J Bastacky; Pavel V Belichenko; M Buddhikot; S Jungles; M Vellard; William C. Mobley; Emil D Kakkis
Intrathecal administration of AAV vectors for the treatment of lysosomal storage in the brains of MPS I mice.
Gene therapy 2006;13(11):917-25.
2006: Jianqing Ding; Elizabeth Allen; Wei Wang; Angela Valle; Chengbiao Wu; Timothy Nardine; Bianxiao Cui; Jing Yi; Anne Taylor; Noo Li Jeon; Steven Chu; Yuen So; Hannes Vogel; Ravi J Tolwani; William C. Mobley; Yanmin Yang
Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport.
Human molecular genetics 2006;15(9):1451-63.
2005: Pavel V Belichenko; Patricia Dickson; M Passage; S Jungles; William C. Mobley; Emil D Kakkis
Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain.
Molecular genetics and metabolism 2005;86(1-2):141-9.
2005: Angela J Villar; Pavel V Belichenko; Anne Marie Gillespie; Heather M Kozy; William C. Mobley; Charles J Epstein
Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.
Mammalian genome : official journal of the International Mammalian Genome Society 2005;16(2):79-90.
2005: Charles Howe; William C. Mobley
Long-distance retrograde neurotrophic signaling.
Current opinion in neurobiology 2005;15(1):40-8.
2005: Katheleen Gardiner; Muriel T Davisson; M Pritchard; David Patterson; Y Groner; Linda S Crnic; Stylianos E Antonarakis; William C. Mobley
Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C.
Cytogenetic and genome research 2005;108(4):269-77.
2004: Pavel V Belichenko; Eliezer Masliah; Alexander M Kleschevnikov; Angela J Villar; Charles J Epstein; Ahmad Salehi; William C. Mobley
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.
The Journal of comparative neurology 2004;480(3):281-98.
2004: Matthew Rizzo; William C. Mobley
An AUPN/ANA survey of department leader opinions on the health of US academic neurology.
Neurology 2004;63(8):1354-6.
2004: Charlie C Pontikis; Claire V Cella; Nisha Parihar; Ming J Lim; Shubo Chakrabarti; Hannah M Mitchison; William C. Mobley; Payam Rezaie; David A Pearce; Jonathan D Cooper
Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation.
Brain research 2004;1023(2):231-42.
2004: Alexander M Kleschevnikov; Pavel V Belichenko; Angela J Villar; Charles J Epstein; Robert C Malenka; William C. Mobley
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(37):8153-60.
2004: Emil D Kakkis; M McEntee; Carole Vogler; S Le; Beth Levy; Pavel V Belichenko; William C. Mobley; Patricia Dickson; S Hanson; Merry Passage
Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.
Molecular genetics and metabolism 2004;83(1-2):163-74.
2004: Louis F Reichardt; William C. Mobley
Going the distance, or not, with neurotrophin signals.
Cell 2004;118(2):141-3.
2004: Charles Howe; William C. Mobley
Signaling endosome hypothesis: A cellular mechanism for long distance communication.
Journal of neurobiology 2004;58(2):207-16.
2004: Jean-Dominique Delcroix; Janice S Valletta; Chenbiao Wu; Charles Howe; Chun-Fai Lai; John D Cooper; Pavel V Belichenko; Ahmad Salehi; William C. Mobley
Trafficking the NGF signal: implications for normal and degenerating neurons.
Progress in brain research 2004;146():3-23.
2003: Jia-Jia Liu; Jianqing Ding; Anthony S Kowal; Timothy Nardine; Elizabeth Allen; Jean-Dominique Delcroix; Chengbiao Wu; William C. Mobley; Elaine Fuchs; Yanmin Yang
BPAG1n4 is essential for retrograde axonal transport in sensory neurons.
The Journal of cell biology 2003;163(2):223-9.
2003: Jean-Dominique Delcroix; Janice S Valletta; Chengbiao Wu; Stephen J Hunt; Anthony S Kowal; William C. Mobley
NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals.
Neuron 2003;39(1):69-84.
2003: Ahmad Salehi; Jean-Dominique Delcroix; William C. Mobley
Traffic at the intersection of neurotrophic factor signaling and neurodegeneration.
Trends in neurosciences 2003;26(2):73-80.
2002: Judy Iles; Colin Blakemore; michael gazzaniga; Ron Kotulak; William C. Mobley
Brain science and public discourse.
Cerebrum : the Dana forum on brain science 2002;4(3):68-70.
2002: Donald Kennedy; William C. Mobley
Are there things we'd rather not know?
Cerebrum : the Dana forum on brain science 2002;4(3):67-8.
2002: Bernard Lo; Marilyn S Albert; Steven Hyman; Erik Parens; Paul Root Wolpe; William C. Mobley
Ethics and the practice of brain science.
Cerebrum : the Dana forum on brain science 2002;4(3):64-6.
2002: Arthur Caplan; William C. Mobley
No brainer--can we cope with the ethical ramifications of new knowledge of the human brain?
Cerebrum : the Dana forum on brain science 2002;4(3):63.
2002: Barbara A Koenig; Henry T Greely; Daniel L Schacter; William J Winslade; William C. Mobley
Brain science and social policy.
Cerebrum : the Dana forum on brain science 2002;4(3):59-62.
2002: Albert R Jonsen; Patricia S Churchland; Antonio R Damasio; Jonathan Moreno; Kenneth F Schaffner; William C. Mobley
Brain science and the self.
Cerebrum : the Dana forum on brain science 2002;4(3):56-8.
2001: Charles Howe; Janice S Valletta; A S Rusnak; William C. Mobley
NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway.
Neuron 2001;32(5):801-14.
2001: John D Cooper; Ahmad Salehi; Jean-Dominique Delcroix; Charles Howe; Pavel V Belichenko; J Chua-Couzens; JF Kilbridge; Elaine J Carlson; Charles J Epstein; William C. Mobley
Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10439-44.
2001: Chengbiao Wu; C F Lai; William C. Mobley
Nerve growth factor activates persistent Rap1 signaling in endosomes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(15):5406-16.
2001: Paul S Mischel; S G Smith; E R Vining; Janice S Valletta; William C. Mobley; Louis F Reichardt
The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA.
The Journal of biological chemistry 2001;276(14):11294-301.
2001: Michael V Sofroniew; Charles Howe; William C. Mobley
Nerve growth factor signaling, neuroprotection, and neural repair.
Annual review of neuroscience 2001;24():1217-81.
2001: John D Cooper; William C. Mobley
Neurotrophic factors as potential therapeutic agents in neuronal ceroid lipofuscinosis.
Advances in genetics 2001;45():169-82.
2000: Eric C Beattie; Charles Howe; A Wilde; Frances M Brodsky; William C. Mobley
NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(19):7325-33.
2000: Pablo Villoslada; Stephen L Hauser; I Bartke; J Unger; N Heald; D Rosenberg; S W Cheung; William C. Mobley; S Fisher; Claude P Genain
Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system.
The Journal of experimental medicine 2000;191(10):1799-806.
2000: C Lynch; William C. Mobley
Comprehensive theory of Alzheimer's disease. The effects of cholesterol on membrane receptor trafficking.
Annals of the New York Academy of Sciences 2000;924():104-11.
1999: C S Huang; J Zhou; A K Feng; C C Lynch; Judith Klumperman; S J DeArmond; William C. Mobley
Nerve growth factor signaling in caveolae-like domains at the plasma membrane.
The Journal of biological chemistry 1999;274(51):36707-14.
1999: Hannah M Mitchison; David J Bernard; Nicholas D E Greene; J D Cooper; Mohammed A Junaid; Raju K Pullarkat; NM de Vos; Martijn H Breuning; Jennie W Owens; William C. Mobley; R Mark Gardiner; BD Lake; Peter E M Taschner; Robert L Nussbaum
Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected].
Neurobiology of disease 1999;6(5):321-34.
1999: Eric Yuen; William C. Mobley
Early BDNF, NT-3, and NT-4 signaling events.
Experimental neurology 1999;159(1):297-308.
1999: John D Cooper; A Messer; A K Feng; J Chua-Couzens; William C. Mobley
Apparent loss and hypertrophy of interneurons in a mouse model of neuronal ceroid lipofuscinosis: evidence for partial response to insulin-like growth factor-1 treatment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(7):2556-67.
1999: A Wilde; Eric C Beattie; L Lem; D A Riethof; SH Liu; William C. Mobley; P Soriano; Frances M Brodsky
EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.
Cell 1999;96(5):677-87.
1998: M J Butte; Peter K Hwang; William C. Mobley; Robert J Fletterick
Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors.
Biochemistry 1998;37(48):16846-52.
1998: Patrick Tremblay; Zeev Meiner; M Galou; Cornelia Heinrich; C Petromilli; T Lisse; J Cayetano; M Torchia; William C. Mobley; H Bujard; Stephen J DeArmond; Stanley B Prusiner
Doxycycline control of prion protein transgene expression modulates prion disease in mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12580-5.
1998: Anne M Fagan; B A Murphy; S N Patel; JF Kilbridge; William C. Mobley; Guojun Bu; David M Holtzman
Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.
Experimental neurology 1998;151(2):314-25.
1998: H Sago; Elaine J Carlson; Desmond J Smith; JF Kilbridge; Edward M Rubin; William C. Mobley; Charles J Epstein; Ting-Ting Huang
Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6256-61.
1998: William C. Mobley
The effect of jet-milling on lyophilized liposomes.
Pharmaceutical research 1998;15(1):149-52.
1998: Stephen J DeArmond; William C. Mobley; D L DeMott; R A Barry; J H Beckstead; Stanley B Prusiner
Changes in the localization of brain prion proteins during scrapie infection.
Neurology 1998;50(1):1271-80; discussion 2.
1997: Hermann M Schätzl; Lajos Laszlo; David M Holtzman; Jörg Tatzelt; Stephen J DeArmond; Richard I Weiner; William C. Mobley; Stanley B Prusiner
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.
Journal of virology 1997;71(11):8821-31.
1997: Tracy T Yeo; J Chua-Couzens; L L Butcher; Dale E Bredesen; John D Cooper; Janice S Valletta; William C. Mobley; Frank M Longo
Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7594-605.
1997: M L Grimes; Eric C Beattie; William C. Mobley
A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9909-14.
1996: M L Grimes; J Zhou; E C Beattie; Eric Yuen; D E Hall; J S Valletta; Kimberly S Topp; Jennifer H LaVail; N W Bunnett; William C. Mobley
Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(24):7950-64.
1996: David M Holtzman; Daniela Santucci; J Kilbridge; J Chua-Couzens; D J Fontana; S E Daniels; R M Johnson; K Chen; Y Sun; Elaine Carlson; Enrico Alleva; Charles J Epstein; William C. Mobley
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13333-8.
1996: Frank M Longo; William C. Mobley
Minimized hormones grow in stature.
Nature biotechnology 1996;14(9):1092.
1996: Eric Yuen; Charles Howe; Yiwen Li; David M Holtzman; William C. Mobley
Nerve growth factor and the neurotrophic factor hypothesis.
Brain & development 1996;18(5):362-8.
1996: Eric Yuen; William C. Mobley
Therapeutic potential of neurotrophic factors for neurological disorders.
Annals of neurology 1996;40(3):346-54.
1996: David M Holtzman; S Lee; Yiwen Li; J Chua-Couzens; H Xia; D S Bredt; William C. Mobley
Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF.
Neurochemical research 1996;21(7):861-8.
1996: Rachael L Neve; J S Valletta; Yiwen Li; M Ventosa-Michelman; David M Holtzman; William C. Mobley
A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor.
Brain research. Molecular brain research 1996;39(1-2):185-97.
1996: William C. Mobley
Recent progress in developmental neurology: exploring the bench to bedside interface.
Current opinion in neurology 1996;9(2):107-112.
1996: Stephen J DeArmond; Y Qiu; K Wong; R Nixon; W Hyun; Stanley B Prusiner; William C. Mobley
Abnormal plasma membrane properties and functions in prion-infected cell lines.
Cold Spring Harbor symposia on quantitative biology 1996;61():531-40.
1996: E C Beattie; J Zhou; M L Grimes; N W Bunnett; Charles Howe; William C. Mobley
A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration.
Cold Spring Harbor symposia on quantitative biology 1996;61():389-406.
1995: Eric Yuen; William C. Mobley
Therapeutic applications of neurotrophic factors in disorders of motor neurons and peripheral nerves.
Molecular medicine today 1995;1(6):278-86.
1995: J Zhou; J S Valletta; M L Grimes; William C. Mobley
Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor.
Journal of neurochemistry 1995;65(3):1146-56.
1995: Yiwen Li; David M Holtzman; L F Kromer; D R Kaplan; J Chua-Couzens; D O Clary; B Knüsel; William C. Mobley
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(4):2888-905.
1995: David M Holtzman; J Kilbridge; Yiwen Li; E T Cunningham; N J Lenn; D O Clary; Louis F Reichardt; William C. Mobley
TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(2):1567-76.
1995: David M Holtzman; J Kilbridge; K S Chen; J Rabin; R Luche; Elaine Carlson; Charles J Epstein; William C. Mobley
Preliminary characterization of the central nervous system in partial trisomy 16 mice.
Progress in clinical and biological research 1995;393():227-40.
1994: M A Burke; William C. Mobley; J Cho; S J Wiegand; Ronald Lindsay; Elliott J Mufson; Jeffrey Kordower
Loss of developing cholinergic basal forebrain neurons following excitotoxic lesions of the hippocampus: rescue by neurotrophins.
Experimental neurology 1994;130(2):178-95.
1994: David M Holtzman; J Kilbridge; D S Bredt; Stephen Matthew Black; Yiwen Li; D O Clary; Louis F Reichardt; William C. Mobley
NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin.
Neurobiology of disease 1994;1(1-2):51-60.
1994: David M Holtzman; William C. Mobley
Neurotrophic factors and neurologic disease.
The Western journal of medicine 1994;161(3):246-54.
1994: C K Chen; Stephen L. Kinsman; David M Holtzman; William C. Mobley; Michael V Johnston
A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1994;12(4):255-62.
1994: L S Higgins; David M Holtzman; J Rabin; William C. Mobley; Barbara Cordell
Transgenic mouse brain histopathology resembles early Alzheimer's disease.
Annals of neurology 1994;35(5):598-607.
1994: J Zhou; David M Holtzman; Richard I Weiner; William C. Mobley
Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3824-8.
1994: L K Taylor; K D Swanson; J Kerigan; William C. Mobley; Gary Landreth
Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells.
The Journal of biological chemistry 1994;269(1):308-18.
1993: David M Holtzman; Yiwen Li; K Chen; F H Gage; C J Epstein; William C. Mobley
Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration.
Neurology 1993;43(12):2668-73.
1992: David M Holtzman; Yiwen Li; Luis F Parada; Stephen L. Kinsman; C K Chen; J S Valletta; J Zhou; J B Long; William C. Mobley
p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF.
Neuron 1992;9(3):465-78.
1992: David M Holtzman; Yiwen Li; Stephen J DeArmond; M P McKinley; F H Gage; Charles J Epstein; William C. Mobley
Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1383-7.
1992: David M Holtzman; R M Bayney; Yiwen Li; H Khosrovi; C N Berger; Charles J Epstein; William C. Mobley
Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.
The EMBO journal 1992;11(2):619-27.
1992: David M Holtzman; Yiwen Li; F H Gage; Charles J Epstein; William C. Mobley
Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome.
Progress in clinical and biological research 1992;379():227-44.
1991: Vassilis E Koliatsos; R E Clatterbuck; Haring J W Nauta; B Knüsel; L E Burton; F Hefti; William C. Mobley; Donald L Price
Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates.
Annals of neurology 1991;30(6):831-40.
1991: Y O Taiwo; Jon D Levine; R M Burch; J E Woo; William C. Mobley
Hyperalgesia induced in the rat by the amino-terminal octapeptide of nerve growth factor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5144-8.
1991: Vassilis E Koliatsos; M D Applegate; B Knüsel; E O Junard; L E Burton; William C. Mobley; F Hefti; Donald L Price
Recombinant human nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat.
Experimental neurology 1991;112(2):161-73.
1991: M Fahnestock; J E Woo; G A Lopez; J Snow; D A Walz; M J Arici; William C. Mobley
beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22.
Biochemistry 1991;30(14):3443-50.
1991: Bruce G Gold; William C. Mobley; S F Matheson
Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(4):943-55.
1991: David M Holtzman; William C. Mobley
Molecular studies in Alzheimer's disease.
Trends in biochemical sciences 1991;16(4):140-4.
1991: Vassilis E Koliatsos; D L Shelton; William C. Mobley; Donald L Price
A novel group of nerve growth factor receptor-immunoreactive neurons in the ventral horn of the lumbar spinal cord.
Brain research 1991;541(1):121-8.
1991: David M Holtzman; Yiwen Li; F H Gage; Stephen J DeArmond; Charles J Epstein; M P McKinley; William C. Mobley
Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease.
Progress in clinical and biological research 1991;373():189-202.
1990: Vassilis E Koliatsos; Haring J W Nauta; R E Clatterbuck; David M Holtzman; William C. Mobley; Donald L Price
Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(12):3801-13.
1990: B Knüsel; L E Burton; Frank M Longo; William C. Mobley; Vassilis E Koliatsos; Donald L Price; F Hefti
Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells.
Experimental neurology 1990;110(3):274-83.
1990: Sukanto Sinha; H F Dovey; Peter Seubert; P J Ward; R W Blacher; M Blaber; R A Bradshaw; M Arici; William C. Mobley; I Lieberburg
The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.
The Journal of biological chemistry 1990;265(16):8983-5.
1990: Karl Burgin; M Neal Waxham; S Rickling; S A Westgate; William C. Mobley; PT Kelly
In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(6):1788-98.
1990: Frank M Longo; T K Vu; William C. Mobley
The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides.
Cell regulation 1990;1(2):189-95.
1990: M P McKinley; Frank M Longo; J S Valletta; F Rahbar; Rachael L Neve; Stanley B Prusiner; William C. Mobley
Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system.
Progress in brain research 1990;86():227-38.
1989: William C. Mobley; J E Woo; Robert H Edwards; R J Riopelle; Frank M Longo; G Weskamp; U Otten; J S Valletta; Michael V Johnston
Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.
Neuron 1989;3(5):655-64.
1989: M P McKinley; Stephen J DeArmond; M Torchia; William C. Mobley; Stanley B Prusiner
Acceleration of scrapie in neonatal Syrian hamsters.
Neurology 1989;39(10):1319-24.
1989: William C. Mobley
Nerve growth factor in Alzheimer's disease: to treat or not to treat?
Neurobiology of aging 1989;10(5):578-80; discussion 588-90.
1989: B N Saffran; J E Woo; William C. Mobley; keith crutcher
Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth.
Brain research 1989;492(1-2):245-54.
1989: Frank R Sharp; M F Gonzalez; K Hisanaga; William C. Mobley; S M Sagar
Induction of the c-fos gene product in rat forebrain following cortical lesions and NGF injections.
Neuroscience letters 1989;100(1-3):117-22.
1989: C H Phelps; F H Gage; John H Growdon; F Hefti; R Harbaugh; Michael V Johnston; ZAVEN KHACHATURIAN; William C. Mobley; Donald L Price; Murray A Raskind
Potential use of nerve growth factor to treat Alzheimer's disease.
Neurobiology of aging 1989;10(2):205-7.
1989: J Hsiang; Alfred Heller; P C Hoffmann; William C. Mobley; B H Wainer
The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures.
Neuroscience 1989;29(1):209-23.
1989: S J De Armond; M Gonzales; William C. Mobley; Alexander A Kon; A Stern; H Prusiner; Stanley B Prusiner
PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer.
Progress in clinical and biological research 1989;317():601-18.
1988: William C. Mobley; Rachael L Neve; Stanley B Prusiner; M P McKinley
Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9811-5.
1988: J B Long; JM Petras; William C. Mobley; John Holaday
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. II. Nonopioid mechanisms mediate loss of motor, sensory and autonomic function.
The Journal of pharmacology and experimental therapeutics 1988;246(3):1167-74.
1988: J B Long; William C. Mobley; John Holaday
Neurological dysfunction after intrathecal injection of dynorphin A (1-13) in the rat. I. Injection procedures modify pharmacological responses.
The Journal of pharmacology and experimental therapeutics 1988;246(3):1158-66.
1988: R H Edwards; M J Selby; William C. Mobley; S L Weinrich; D E Hruby; W J Rutter
Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector.
Molecular and cellular biology 1988;8(6):2456-64.
1988: W L Gerber; V E de la Pena; William C. Mobley
Infertility, chemical exposure, and farming in Iowa: absence of an association.
Urology 1988;31(1):46-50.
1987: Michael V Johnston; JL Rutkowski; B H Wainer; J B Long; William C. Mobley
NGF effects on developing forebrain cholinergic neurons are regionally specific.
Neurochemical research 1987;12(11):985-94.
1987: S J DeArmond; William C. Mobley; D L DeMott; R A Barry; J H Beckstead; Stanley B Prusiner
Changes in the localization of brain prion proteins during scrapie infection.
Neurology 1987;37(8):1271-80.
1986: William C. Mobley; JL Rutkowski; Gihan I. Tennekoon; J Gemski; K Buchanan; Michael V Johnston
Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons.
Brain research 1986;387(1):53-62.
1986: William C. Mobley; S A Loening; A S Narayana; D A Culp
Use of intravesical cisplatin and mitomycin-C for recurrent transitional cell carcinoma of bladder refractory to thiotepa.
Urology 1986;27(4):335-9.
1985: C A Kitt; R G Struble; L C Cork; William C. Mobley; Lary Walker; T H Joh; Donald L Price
Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates.
Neuroscience 1985;16(3):691-9.
1985: William C. Mobley; JL Rutkowski; Gihan I. Tennekoon; K Buchanan; Michael V Johnston
Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor.
Science (New York, N.Y.) 1985;229(4710):284-7.
1984: C A Kitt; Donald L Price; R G Struble; L C Cork; B H Wainer; M W Becher; William C. Mobley
Evidence for cholinergic neurites in senile plaques.
Science (New York, N.Y.) 1984;226(4681):1443-5.
1984: William C. Mobley; S A Loening; A S Narayana
Combination perineal cryosurgery and external radiation therapy for adenocarcinoma of prostate.
Urology 1984;24(1):11-4.
1982: William C. Mobley; Jerry Wolinsky
Scientific overview of inflammatory demyelinating polyneuropathy and design of the North American collaborative study of plasma exchange in Guillain-Barre syndrome.
Progress in clinical and biological research 1982;106():159-87.
1980: A Asbury; R Fisher; Guy M McKhann; William C. Mobley; A Server
Guillain-Barré syndrome: is there a role for plasmapheresis?
Neurology 1980;30(10):1112.
1978: R Shapira; William C. Mobley; S B Thiele; M R Wilhelmi; A Wallace; R F Kibler
Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase of rabbit brain by sedimentation in a continuous sucrose gradient.
Journal of neurochemistry 1978;30(4):735-44.
1977: William C. Mobley; A C Server; D N Ishii; R J Riopelle; E M Shooter
Nerve growth factor (third of three parts).
The New England journal of medicine 1977;297(22):1211-8.
1977: William C. Mobley; A C Server; D N Ishii; R J Riopelle; E M Shooter
Nerve growth factor (second of three parts).
The New England journal of medicine 1977;297(21):1149-58.
1977: William C. Mobley; A C Server; D N Ishii; R J Riopelle; E M Shooter
Nerve growth factor (first of three parts).
The New England journal of medicine 1977;297(20):1096-104.
1976: William C. Mobley; A Schenker; E M Shooter
Characterization and isolation of proteolytically modified nerve growth factor.
Biochemistry 1976;15(25):5543-52.
1975: B Bjerre; A Björklund; William C. Mobley; E Rosengren
Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse.
Brain research 1975;94(2):263-77.
1974: U Stenevi; B Bjerre; A Björklund; William C. Mobley
Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurones.
Brain research 1974;69(2):217-34.
1974: J B Moore; William C. Mobley; E M Shooter
Proteolytic modification of the beta nerve growth factor protein.
Biochemistry 1974;13(4):833-40.
1973: B Bjerre; A Björklund; William C. Mobley
A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibres in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine.
Zeitschrift für Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948) 1973;146(1):15-43.