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Ralph A. Nixon

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Disorders

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Anatomy

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Physiology

Axonal Transport

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Publications

TOP 3
Yuan Aidong; Sasaki Takahiro; Rao Mala V; Kumar Asok; Kanumuri Vivek; Dunlop David S; Liem Ronald K; Nixon Ralph A
Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons.
Choi Jennifer H K; Berger Jason D; Mazzella Matthew J; Morales-Corraliza Jose; Cataldo Anne M; Nixon Ralph A; Ginsberg Stephen D; Levy Efrat; Mathews Paul M
Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.
Chen Yuanxin; Dyakin Victor V; Branch Craig A; Ardekani Babak; Yang Dunsheng; Guilfoyle David N; Peterson Jesse; Peterhoff Corrinne; Ginsberg Stephen D; Cataldo Anne M; Nixon Ralph A
In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model.

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All Publications

2009: Yuan Aidong; Sasaki Takahiro; Rao Mala V; Kumar Asok; Kanumuri Vivek; Dunlop David S; Liem Ronald K; Nixon Ralph A
Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(36):11316-29.
2009: Choi Jennifer H K; Berger Jason D; Mazzella Matthew J; Morales-Corraliza Jose; Cataldo Anne M; Nixon Ralph A; Ginsberg Stephen D; Levy Efrat; Mathews Paul M
Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.
Journal of neurochemistry 2009;110(6):1818-27.
2009: Chen Yuanxin; Dyakin Victor V; Branch Craig A; Ardekani Babak; Yang Dunsheng; Guilfoyle David N; Peterson Jesse; Peterhoff Corrinne; Ginsberg Stephen D; Cataldo Anne M; Nixon Ralph A
In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model.
Neurobiology of aging 2009;30(9):1453-65.
2009: Basavarajappa Balapal S; Nixon Ralph A; Arancio Ottavio
Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration.
Mini reviews in medicinal chemistry 2009;9(4):448-62.
2009: Wilson Donald A; Nixon Ralph A
Sniffing out a function for prion proteins.
Nature neuroscience 2009;12(1):7-8.
2009: Mi Weiqian; Jung Sonia S; Yu Haung; Schmidt Stephen D; Nixon Ralph A; Mathews Paul M; Tagliavini Fabrizio; Levy Efrat
Complexes of amyloid-beta and cystatin C in the human central nervous system.
Journal of Alzheimer's disease : JAD 2009;18(2):273-80.
2009: Yang Dun-Sheng; Lee Ju-Hyun; Nixon Ralph A
Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases.
Methods in enzymology 2009;453():111-44.
2008: Planel Emmanuel; Krishnamurthy Pavan; Miyasaka Tomohiro; Liu Li; Herman Mathieu; Kumar Asok; Bretteville Alexis; Figueroa Helen Y; Yu Wai Haung; Whittington Robert A; Davies Peter; Takashima Akihiko; Nixon Ralph A; Duff Karen E
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(48):12798-807.
2008: Rao Mala V; Mohan Panaiyur S; Peterhoff Corrinne M; Yang Dun-Sheng; Schmidt Stephen D; Stavrides Philip H; Campbell Jabbar; Chen Yuanxin; Jiang Ying; Paskevich Peter A; Cataldo Anne M; Haroutunian Vahram; Nixon Ralph A
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12241-54.
2008: Veeranna; Lee Ju-Hyun; Pareek Tej K; Jaffee Howard; Boland Barry; Vinod K Yaragudri; Amin Niranjana; Kulkarni Ashok B; Pant Harish C; Nixon Ralph A
Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases.
Journal of neurochemistry 2008;107(1):35-49.
2008: Yang Dun-Sheng; Kumar Asok; Stavrides Philip; Peterson Jesse; Peterhoff Corrine M; Pawlik Monika; Levy Efrat; Cataldo Anne M; Nixon Ralph A
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease.
The American journal of pathology 2008;173(3):665-81.
2008: Trinchese Fabrizio; Fa' Mauro; Liu Shumin; Zhang Hong; Hidalgo Ariel; Schmidt Stephen D; Yamaguchi Hisako; Yoshii Narihiko; Mathews Paul M; Nixon Ralph A; Arancio Ottavio
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.
The Journal of clinical investigation 2008;118(8):2796-807.
2008: Cataldo Anne M; Mathews Paul M; Boiteau Anne Boyer; Hassinger Linda C; Peterhoff Corrinne M; Jiang Ying; Mullaney Kerry; Neve Rachael L; Gruenberg Jean; Nixon Ralph A
Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.
The American journal of pathology 2008;173(2):370-84.
2008: Boland Barry; Kumar Asok; Lee Sooyeon; Platt Frances M; Wegiel Jerzy; Yu W Haung; Nixon Ralph A
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(27):6926-37.
2008: Nixon Ralph A; Yang Dun-Sheng; Lee Ju-Hyun
Neurodegenerative lysosomal disorders: a continuum from development to late age.
Autophagy 2008;4(5):590-9.
2008: Azmitia Efrain C; Nixon Ralph
Dystrophic serotonergic axons in neurodegenerative diseases.
Brain research 2008;1217():185-94.
2008: Yuan Aidong; Kumar Asok; Peterhoff Corrinne; Duff Karen; Nixon Ralph A
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(7):1682-7.
2008: Klionsky Daniel J; Abeliovich Hagai; Agostinis Patrizia; Agrawal Devendra K; Aliev Gjumrakch; Askew David S; Baba Misuzu; Baehrecke Eric H; Bahr Ben A; Ballabio Andrea; Bamber Bruce A; Bassham Diane C; Bergamini Ettore; Bi Xiaoning; Biard-Piechaczyk Martine; Blum Janice S; Bredesen Dale E; Brodsky Jeffrey L; Brumell John H; Brunk Ulf T; Bursch Wilfried; Camougrand Nadine; Cebollero Eduardo; Cecconi Francesco; Chen Yingyu; Chin Lih-Shen; Choi Augustine; Chu Charleen T; Chung Jongkyeong; Clarke Peter G H; Clark Robert S B; Clarke Steven G; Clavé Corinne; Cleveland John L; Codogno Patrice; Colombo María I; Coto-Montes Ana; Cregg James M; Cuervo Ana Maria; Debnath Jayanta; Demarchi Francesca; Dennis Patrick B; Dennis Phillip A; Deretic Vojo; Devenish Rodney J; Di Sano Federica; Dice J Fred; Difiglia Marian; Dinesh-Kumar Savithramma; Distelhorst Clark W; Djavaheri-Mergny Mojgan; Dorsey Frank C; Dröge Wulf; Dron Michel; Dunn William A; Duszenko Michael; Eissa N Tony; Elazar Zvulun; Esclatine Audrey; Eskelinen Eeva-Liisa; Fésüs László; Finley Kim D; Fuentes José M; Fueyo Juan; Fujisaki Kozo; Galliot Brigitte; Gao Fen-Biao; Gewirtz David A; Gibson Spencer B; Gohla Antje; Goldberg Alfred L; Gonzalez Ramon; González-Estévez Cristina; Gorski Sharon; Gottlieb Roberta A; Häussinger Dieter; He You-Wen; Heidenreich Kim; Hill Joseph A; Høyer-Hansen Maria; Hu Xun; Huang Wei-Pang; Iwasaki Akiko; Jäättelä Marja; Jackson William T; Jiang Xuejun; Jin Shengkan; Johansen Terje; Jung Jae U; Kadowaki Motoni; Kang Chanhee; Kelekar Ameeta; Kessel David H; Kiel Jan A K W; Kim Hong Pyo; Kimchi Adi; Kinsella Timothy J; Kiselyov Kirill; Kitamoto Katsuhiko; Knecht Erwin; Komatsu Masaaki; Kominami Eiki; Kondo Seiji; Kovács Attila L; Kroemer Guido; Kuan Chia-Yi; Kumar Rakesh; Kundu Mondira; Landry Jacques; Laporte Marianne; Le Weidong; Lei Huan-Yao; Lenardo Michael J; Levine Beth; Lieberman Andrew; Lim Kah-Leong; Lin Fu-Cheng; Liou Willisa; Liu Leroy F; Lopez-Berestein Gabriel; López-Otín Carlos; Lu Bo; Macleod Kay F; Malorni Walter; Martinet Wim; Matsuoka Ken; Mautner Josef; Meijer Alfred J; Meléndez Alicia; Michels Paul; Miotto Giovanni; Mistiaen Wilhelm P; Mizushima Noboru; Mograbi Baharia; Monastyrska Iryna; Moore Michael N; Moreira Paula I; Moriyasu Yuji; Motyl Tomasz; Münz Christian; Murphy Leon O; Naqvi Naweed I; Neufeld Thomas P; Nishino Ichizo; Nixon Ralph A; Noda Takeshi; Nürnberg Bernd; Ogawa Michinaga; Oleinick Nancy L; Olsen Laura J; Ozpolat Bulent; Paglin Shoshana; Palmer Glen E; Papassideri Issidora; Parkes Miles; Perlmutter David H; Perry George; Piacentini Mauro; Pinkas-Kramarski Ronit; Prescott Mark; Proikas-Cezanne Tassula; Raben Nina; Rami Abdelhaq; Reggiori Fulvio; Rohrer Bärbel; Rubinsztein David C; Ryan Kevin M; Sadoshima Junichi; Sakagami Hiroshi; Sakai Yasuyoshi; Sandri Marco; Sasakawa Chihiro; Sass Miklós; Schneider Claudio; Seglen Per O; Seleverstov Oleksandr; Settleman Jeffrey; Shacka John J; Shapiro Irving M; Sibirny Andrei; Silva-Zacarin Elaine C M; Simon Hans-Uwe; Simone Cristiano; Simonsen Anne; Smith Mark A; Spanel-Borowski Katharina; Srinivas Vickram; Steeves Meredith; Stenmark Harald; Stromhaug Per E; Subauste Carlos S; Sugimoto Seiichiro; Sulzer David; Suzuki Toshihiko; Swanson Michele S; Tabas Ira; Takeshita Fumihiko; Talbot Nicholas J; Tallóczy Zsolt; Tanaka Keiji; Tanaka Kozo; Tanida Isei; Taylor Graham S; Taylor J Paul; Terman Alexei; Tettamanti Gianluca; Thompson Craig B; Thumm Michael; Tolkovsky Aviva M; Tooze Sharon A; Truant Ray; Tumanovska Lesya V; Uchiyama Yasuo; Ueno Takashi; Uzcátegui Néstor L; van der Klei Ida; Vaquero Eva C; Vellai Tibor; Vogel Michael W; Wang Hong-Gang; Webster Paul; Wiley John W; Xi Zhijun; Xiao Gutian; Yahalom Joachim; Yang Jin-Ming; Yap George; Yin Xiao-Ming; Yoshimori Tamotsu; Yu Li; Yue Zhenyu; Yuzaki Michisuke; Zabirnyk Olga; Zheng Xiaoxiang; Zhu Xiongwei; Deter Russell L
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy 2008;4(2):151-75.
2007: Nixon Ralph A
Autophagy, amyloidogenesis and Alzheimer disease.
Journal of cell science 2007;120(Pt 23):4081-91.
2007: Mi Weiqian; Pawlik Monika; Sastre Magdalena; Jung Sonia S; Radvinsky David S; Klein Andrew M; Sommer John; Schmidt Stephen D; Nixon Ralph A; Mathews Paul M; Levy Efrat
Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models.
Nature genetics 2007;39(12):1440-2.
2007: Battaglia Fortunato; Wang Hoau-Yan; Ghilardi M Felice; Gashi Eleonora; Quartarone Angelo; Friedman Eitan; Nixon Ralph A
Cortical plasticity in Alzheimer's disease in humans and rodents.
Biological psychiatry 2007;62(12):1405-12.
2007: Gandy Sam; Zhang Yun-wu; Ikin Annat; Schmidt Stephen D; Bogush Alexey; Levy Efrat; Sheffield Roxanne; Nixon Ralph A; Liao Francesca-Fang; Mathews Paul M; Xu Huaxi; Ehrlich Michelle E
Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.
Journal of neurochemistry 2007;102(3):619-26.
2007: Falangola M F; Dyakin V V; Lee S P; Bogart A; Babb J S; Duff K; Nixon R; Helpern J A
Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease.
NMR in biomedicine 2007;20(3):343-51.
2006: Boland Barry; Nixon Ralph A
Neuronal macroautophagy: from development to degeneration.
Molecular aspects of medicine 2006;27(5-6):503-19.
2006: Liang Jing; Yin Chaobo; Doong Howard; Fang Shengyun; Peterhoff Corrine; Nixon Ralph A; Monteiro Mervyn J
Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation.
Journal of cell science 2006;119(Pt 19):4011-24.
2006: Yuan Aidong; Rao Mala V; Sasaki Takahiro; Chen Yuanxin; Kumar Asok; Veeranna; Liem Ronald K H; Eyer Joel; Peterson Alan C; Julien Jean-Pierre; Nixon Ralph A
Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(39):10006-19.
2006: Nixon Ralph A
Autophagy in neurodegenerative disease: friend, foe or turncoat?
Trends in neurosciences 2006;29(9):528-35.
2006: Butler David; Nixon Ralph A; Bahr Ben A
Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases.
Autophagy 2006;2(3):234-7.
2006: Salehi Ahmad; Delcroix Jean-Dominique; Belichenko Pavel V; Zhan Ke; Wu Chengbiao; Valletta Janice S; Takimoto-Kimura Ryoko; Kleschevnikov Alexander M; Sambamurti Kumar; Chung Peter P; Xia Weiming; Villar Angela; Campbell William A; Kulnane Laura Shapiro; Nixon Ralph A; Lamb Bruce T; Epstein Charles J; Stokin Gorazd B; Goldstein Lawrence S B; Mobley William C
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Neuron 2006;51(1):29-42.
2006: Yuan Aidong; Nixon Ralph A; Rao Mala V
Deleting the phosphorylated tail domain of the neurofilament heavy subunit does not alter neurofilament transport rate in vivo.
Neuroscience letters 2006;393(2-3):264-8.
2006: Nixon Ralph A; Cataldo Anne M
Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):277-89.
2005: Yu W Haung; Cuervo Ana Maria; Kumar Asok; Peterhoff Corrinne M; Schmidt Stephen D; Lee Ju-Hyun; Mohan Panaiyur S; Mercken Marc; Farmery Mark R; Tjernberg Lars O; Jiang Ying; Duff Karen; Uchiyama Yasuo; Näslund Jan; Mathews Paul M; Cataldo Anne M; Nixon Ralph A
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
The Journal of cell biology 2005;171(1):87-98.
2005: de Grey Aubrey D N J; Alvarez Pedro J J; Brady Roscoe O; Cuervo Ana Maria; Jerome W Gray; McCarty Perry L; Nixon Ralph A; Rittmann Bruce E; Sparrow Janet R
Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases.
Ageing research reviews 2005;4(3):315-38.
2005: Mastrangelo Peter; Mathews Paul M; Chishti M Azhar; Schmidt Stephen D; Gu Yongjun; Yang Jing; Mazzella Matthew J; Coomaraswamy Janaky; Horne Patrick; Strome Bob; Pelly Heather; Levesque Georges; Ebeling Chris; Jiang Ying; Nixon Ralph A; Rozmahel Richard; Fraser Paul E; St George-Hyslop Peter; Carlson George A; Westaway David
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(25):8972-7.
2005: Falangola M F; Ardekani B A; Lee S-P; Babb J S; Bogart A; Dyakin V V; Nixon R; Duff K; Helpern J A
Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology.
Journal of neuroscience methods 2005;144(1):91-7.
2005: Rubinsztein David C; DiFiglia Marian; Heintz Nathaniel; Nixon Ralph A; Qin Zheng-Hong; Ravikumar Brinda; Stefanis Leonidas; Tolkovsky Aviva
Autophagy and its possible roles in nervous system diseases, damage and repair.
Autophagy 2005;1(1):11-22.
2005: Nixon Ralph A
Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases.
Neurobiology of aging 2005;26(3):373-82.
2005: Falangola Maria F; Lee Sang-Pil; Nixon Ralph A; Duff Karen; Helpern Joseph A
Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice.
Neurochemical research 2005;30(2):201-5.
2005: Nixon Ralph A; Wegiel Jerzy; Kumar Asok; Yu Wai Haung; Peterhoff Corrinne; Cataldo Anne; Cuervo Ana Maria
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.
Journal of neuropathology and experimental neurology 2005;64(2):113-22.
2005: Schmidt Stephen D; Nixon Ralph A; Mathews Paul M
ELISA method for measurement of amyloid-beta levels.
Methods in molecular biology (Clifton, N.J.) 2005;299():279-97.
2005: Schmidt Stephen D; Jiang Ying; Nixon Ralph A; Mathews Paul M
Tissue processing prior to protein analysis and amyloid-beta quantitation.
Methods in molecular biology (Clifton, N.J.) 2005;299():267-78.
2004: Yu W H; Kumar A; Peterhoff C; Shapiro Kulnane L; Uchiyama Y; Lamb B T; Cuervo A M; Nixon R A
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.
The international journal of biochemistry & cell biology 2004;36(12):2531-40.
2004: Cataldo Anne M; Petanceska Suzana; Terio Nicole B; Peterhoff Corrinne M; Durham Robert; Mercken Marc; Mehta Pankaj D; Buxbaum Joseph; Haroutunian Vahram; Nixon Ralph A
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.
Neurobiology of aging 2004;25(10):1263-72.
2004: Carter Troy L; Verdile Giuseppe; Groth David; Bogush Alexey; Thomas Stefani; Shen Patrick; Fraser Paul E; Mathews Paul; Nixon Ralph A; Ehrlich Michelle E; Kwok John B J; St George-Hyslop Peter; Schofield Peter; Li Yueming; Yang Austin; Martins Ralph N; Gandy Sam
Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells.
Alzheimer disease and associated disorders 2004;18(4):261-3.
2004: Lee Sang-Pil; Falangola Maria F; Nixon Ralph A; Duff Karen; Helpern Joseph A
Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;52(3):538-44.
2004: Veeranna; Kaji Takahide; Boland Barry; Odrljin Tatjana; Mohan Panaiyur; Basavarajappa Balapal S; Peterhoff Corrinne; Cataldo Anne; Rudnicki Anna; Amin Niranjana; Li Bing Sheng; Pant Harish C; Hungund Basalingappa L; Arancio Ottavio; Nixon Ralph A
Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease.
The American journal of pathology 2004;165(3):795-805.
2004: Sastre Magdalena; Calero Miguel; Pawlik Monika; Mathews Paul M; Kumar Asok; Danilov Vlatko; Schmidt Stephen D; Nixon Ralph A; Frangione Blas; Levy Efrat
Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation.
Neurobiology of aging 2004;25(8):1033-43.
2004: Cataldo Anne M; Peterhoff Corrinne M; Schmidt Stephen D; Terio Nicole B; Duff Karen; Beard Margaret; Mathews Paul M; Nixon Ralph A
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology.
Journal of neuropathology and experimental neurology 2004;63(8):821-30.
2004: Yao Jun; Petanceska Suzana S; Montine Thomas J; Holtzman David M; Schmidt Stephen D; Parker Carolyn A; Callahan Michael J; Lipinski William J; Bisgaier Charles L; Turner Brian A; Nixon Ralph A; Martins Ralph N; Ouimet Charles; Smith Jonathan D; Davies Peter; Laska Eugene; Ehrlich Michelle E; Walker Lary C; Mathews Paul M; Gandy Sam
Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.
Journal of neurochemistry 2004;90(4):1011-8.
2004: Sadowski Marcin; Pankiewicz Joanna; Scholtzova Henrieta; Ji Yong; Quartermain David; Jensen Catrin H; Duff Karen; Nixon Ralph A; Gruen Rand J; Wisniewski Thomas
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.
Journal of neuropathology and experimental neurology 2004;63(5):418-28.
2004: Helpern Joseph A; Lee Sang-Pil; Falangola Maria F; Dyakin Victor V; Bogart Adam; Ardekani Babak; Duff Karen; Branch Craig; Wisniewski Thomas; de Leon Mony J; Wolf Oliver; O'Shea Jacqueline; Nixon Ralph A
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(4):794-8.
2004: Laudon Hanna; Mathews Paul M; Karlström Helena; Bergman Anna; Farmery Mark R; Nixon Ralph A; Winblad Bengt; Gandy Samuel E; Lendahl Urban; Lundkvist Johan; Näslund Jan
Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.
Journal of neurochemistry 2004;89(1):44-53.
2004: Nixon Ralph A
Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.
The American journal of pathology 2004;164(3):757-61.
2004: Pawlik Monika; Sastre Magdalena; Calero Miguel; Mathews Paul M; Schmidt Stephen D; Nixon Ralph A; Levy Efrat
Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid Beta Peptide.
Journal of molecular neuroscience : MN 2004;22(1-2):13-8.
2003: Rao Mala V; Campbell Jabbar; Yuan Aidong; Kumar Asok; Gotow Takahiro; Uchiyama Yasuo; Nixon Ralph A
The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate.
The Journal of cell biology 2003;163(5):1021-31.
2003: Phinney Amie L; Drisaldi Bettina; Schmidt Stephen D; Lugowski Stan; Coronado Veronica; Liang Yan; Horne Patrick; Yang Jing; Sekoulidis Joannis; Coomaraswamy Janaky; Chishti M Azhar; Cox Diane W; Mathews Paul M; Nixon Ralph A; Carlson George A; St George-Hyslop Peter; Westaway David
In vivo reduction of amyloid-beta by a mutant copper transporter.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14193-8.
2003: Yuan Aidong; Rao Mala V; Kumar Asok; Julien Jean-Pierre; Nixon Ralph A
Neurofilament transport in vivo minimally requires hetero-oligomer formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(28):9452-8.
2003: Nixon Ralph A
The calpains in aging and aging-related diseases.
Ageing research reviews 2003;2(4):407-18.
2003: Grbovic Olivera M; Mathews Paul M; Jiang Ying; Schmidt Stephen D; Dinakar Ravi; Summers-Terio Nicole B; Ceresa Brian P; Nixon Ralph A; Cataldo Anne M
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production.
The Journal of biological chemistry 2003;278(33):31261-8.
2003: Cataldo Anne M; Petanceska Suzana; Peterhoff Corrinne M; Terio Nicole B; Epstein Charles J; Villar Angela; Carlson Elaine J; Staufenbiel Matthias; Nixon Ralph A
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(17):6788-92.
2003: Mathews Paul M; Nixon Ralph A
Setback for an Alzheimer's disease vaccine: lessons learned.
Neurology 2003;61(1):7-8.
2003: Rao Mala V; Nixon Ralph A
Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review.
Neurochemical research 2003;28(7):1041-7.
2003: Noble Wendy; Olm Vicki; Takata Kazuyuki; Casey Evelyn; Mary O; Meyerson Jordana; Gaynor Kate; LaFrancois John; Wang Lili; Kondo Takayuki; Davies Peter; Burns Mark; Veeranna; Nixon Ralph; Dickson Dennis; Matsuoka Yasuji; Ahlijanian Michael; Lau Lit-Fui; Duff Karen
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
Neuron 2003;38(4):555-65.
2003: Tatton William; Chen David; Chalmers-Redman Ruth; Wheeler Larry; Nixon Ralph; Tatton Nadine
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation.
Survey of ophthalmology 2003;48 Suppl 1():S25-37.
2003: Battaglia Fortunato; Trinchese Fabrizio; Liu Shumin; Walter Sean; Nixon Ralph A; Arancio Ottavio
Calpain inhibitors, a treatment for Alzheimer's disease: position paper.
Journal of molecular neuroscience : MN 2003;20(3):357-62.
2002: Rao Mala V; Engle Linda J; Mohan Panaiyur S; Yuan Aidong; Qiu Dike; Cataldo Anne; Hassinger Linda; Jacobsen Stephen; Lee Virginia M-Y; Andreadis Athena; Julien Jean-Pierre; Bridgman Paul C; Nixon Ralph A
Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density.
The Journal of cell biology 2002;159(2):279-90.
2002: Rozmahel Richard; Mount Howard T J; Chen Fusheng; Nguyen Van; Huang Jean; Erdebil Serap; Liauw Jennifer; Yu Gang; Hasegawa Hiroshe; Gu YongJun; Song You-Qiang; Schmidt Stephen D; Nixon Ralph A; Mathews Paul M; Bergeron Catherine; Fraser Paul; Westaway David; St George-Hyslop Peter
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14452-7.
2002: Mathews Paul M; Jiang Ying; Schmidt Stephen D; Grbovic Olivera M; Mercken Marc; Nixon Ralph A
Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments.
The Journal of biological chemistry 2002;277(39):36415-24.
2002: Di Rosa Gabriella; Odrijin Tatjana; Nixon Ralph A; Arancio Ottavio
Calpain inhibitors: a treatment for Alzheimer's disease.
Journal of molecular neuroscience : MN 2002;19(1-2):135-41.
2002: Rao Mala V; Garcia Michael L; Miyazaki Yukio; Gotow Takahiro; Yuan Aidong; Mattina Salvatore; Ward Chris M; Calcutt Nigel A; Uchiyama Yasuo; Nixon Ralph A; Cleveland Don W
Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport.
The Journal of cell biology 2002;158(4):681-93.
2002: Adamec Emil; Murrell Jill R; Takao Masaki; Hobbs Wendy; Nixon Ralph A; Ghetti Bernardino; Vonsattel Jean P
P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein.
Journal of the neurological sciences 2002;200(1-2):85-93.
2002: Yang Dun-Sheng; Tandon Anurag; Chen Fusheng; Yu Gang; Yu Haung; Arawaka Shigeki; Hasegawa Hiroshi; Duthie Monika; Schmidt Stephen D; Ramabhadran Triprayer V; Nixon Ralph A; Mathews Paul M; Gandy Samuel E; Mount Howard T J; St George-Hyslop Peter; Fraser Paul E
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
The Journal of biological chemistry 2002;277(31):28135-42.
2002: Adamec Emil; Mohan Panaiyur; Vonsattel Jean P; Nixon Ralph A
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Acta neuropathologica 2002;104(1):92-104.
2002: Mathews Paul M; Guerra Carolyn B; Jiang Ying; Grbovic Olivera M; Kao Benjamin H; Schmidt Stephen D; Dinakar Ravi; Mercken Marc; Hille-Rehfeld Annette; Rohrer Jack; Mehta Pankaj; Cataldo Anne M; Nixon Ralph A
Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.
The Journal of biological chemistry 2002;277(7):5299-307.
2001: Cataldo A; Rebeck G W; Ghetri B; Hulette C; Lippa C; Van Broeckhoven C; van Duijn C; Cras P; Bogdanovic N; Bird T; Peterhoff C; Nixon R
Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders.
Annals of neurology 2001;50(5):661-5.
2001: Adamec E; Yang F; Cole G M; Nixon R A
Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration.
Brain research. Brain research protocols 2001;7(3):193-202.
2000: Janus C; Pearson J; McLaurin J; Mathews P M; Jiang Y; Schmidt S D; Chishti M A; Horne P; Heslin D; French J; Mount H T; Nixon R A; Mercken M; Bergeron C; Fraser P E; St George-Hyslop P; Westaway D
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.
Nature 2000;408(6815):979-82.
2000: Sánchez I; Hassinger L; Sihag R K; Cleveland D W; Mohan P; Nixon R A
Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation.
The Journal of cell biology 2000;151(5):1013-24.
2000: Mathews P M; Cataldo A M; Kao B H; Rudnicki A G; Qin X; Yang J L; Jiang Y; Picciano M; Hulette C; Lippa C F; Bird T D; Nochlin D; Walter J; Haass C; Lévesque L; Fraser P E; Andreadis A; Nixon R A
Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.
Molecular medicine (Cambridge, Mass.) 2000;6(10):878-91.
2000: Nixon R A; Cataldo A M; Mathews P M
The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review.
Neurochemical research 2000;25(9-10):1161-72.
2000: Anderson A J; Stoltzner S; Lai F; Su J; Nixon R A
Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL.
Neurobiology of aging 2000;21(4):511-24.
2000: Cataldo A M; Peterhoff C M; Troncoso J C; Gomez-Isla T; Hyman B T; Nixon R A
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.
The American journal of pathology 2000;157(1):277-86.
2000: Nixon R A
A "protease activation cascade" in the pathogenesis of Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;924():117-31.
2000: Adamec E; Mohan P S; Cataldo A M; Vonsattel J P; Nixon R A
Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease.
Neuroscience 2000;100(3):663-75.
1999: Adamec E; Vonsattel J P; Nixon R A
DNA strand breaks in Alzheimer's disease.
Brain research 1999;849(1-2):67-77.
1999: Lévesque L; Annaert W; Craessaerts K; Mathews P M; Seeger M; Nixon R A; Van Leuven F; Gandy S; Westaway D; St George-Hyslop P; De Strooper B; Fraser P E
Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.
Molecular medicine (Cambridge, Mass.) 1999;5(8):542-54.
1999: Lai F; Kammann E; Rebeck G W; Anderson A; Chen Y; Nixon R A
APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome.
Neurology 1999;53(2):331-6.
1999: Buchner K; Adamec E; Beermann M L; Nixon R A
Isoform-specific translocation of protein kinase C following glutamate administration in primary hippocampal neurons.
Brain research. Molecular brain research 1999;64(2):222-35.
1999: Sihag R K; Jaffe H; Nixon R A; Rong X
Serine-23 is a major protein kinase A phosphorylation site on the amino-terminal head domain of the middle molecular mass subunit of neurofilament proteins.
Journal of neurochemistry 1999;72(2):491-9.
1998: Nixon R A
Dynamic behavior and organization of cytoskeletal proteins in neurons: reconciling old and new findings.
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(10):798-807.
1998: Wang K K; Posmantur R; Nadimpalli R; Nath R; Mohan P; Nixon R A; Talanian R V; Keegan M; Herzog L; Allen H
Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis.
Archives of biochemistry and biophysics 1998;356(2):187-96.
1998: Adamec E; Didier M; Nixon R A
Developmental regulation of the recovery process following glutamate-induced calcium rise in rodent primary neuronal cultures.
Brain research. Developmental brain research 1998;108(1-2):101-10.
1998: Troncoso J C; Cataldo A M; Nixon R A; Barnett J L; Lee M K; Checler F; Fowler D R; Smialek J E; Crain B; Martin L J; Kawas C H
Neuropathology of preclinical and clinical late-onset Alzheimer's disease.
Annals of neurology 1998;43(5):673-6.
1998: Nixon R A
The slow axonal transport debate.
Trends in cell biology 1998;8(3):100.
1998: Adamec E; Beermann M L; Nixon R A
Calpain I activation in rat hippocampal neurons in culture is NMDA receptor selective and not essential for excitotoxic cell death.
Brain research. Molecular brain research 1998;54(1):35-48.
1998: Nixon R A
The slow axonal transport of cytoskeletal proteins.
Current opinion in cell biology 1998;10(1):87-92.
1998: Capell A; Grünberg J; Pesold B; Diehlmann A; Citron M; Nixon R; Beyreuther K; Selkoe D J; Haass C
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
The Journal of biological chemistry 1998;273(6):3205-11.
1998: Li J; Nixon R; Messer A; Berman S; Bursztajn S
Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord.
Brain research. Molecular brain research 1998;53(1-2):174-86.
1998: Shiurba R A; Spooner E T; Ishiguro K; Takahashi M; Yoshida R; Wheelock T R; Imahori K; Cataldo A M; Nixon R A
Immunocytochemistry of formalin-fixed human brain tissues: microwave irradiation of free-floating sections.
Brain research. Brain research protocols 1998;2(2):109-19.
1997: Capell A; Saffrich R; Olivo J C; Meyn L; Walter J; Grünberg J; Mathews P; Nixon R; Dotti C; Haass C
Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation.
Journal of neurochemistry 1997;69(6):2432-40.
1997: Cataldo A M; Barnett J L; Pieroni C; Nixon R A
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(16):6142-51.
1997: Grynspan F; Griffin W R; Cataldo A; Katayama S; Nixon R A
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.
Brain research 1997;763(2):145-58.
1997: Shea T B; Dahl D C; Nixon R A; Fischer I
Triton-soluble phosphovariants of the heavy neurofilament subunit in developing and mature mouse central nervous system.
Journal of neuroscience research 1997;48(6):515-23.
1997: Adamec E; Mercken M; Beermann M L; Didier M; Nixon R A
Acute rise in the concentration of free cytoplasmic calcium leads to dephosphorylation of the microtubule-associated protein tau.
Brain research 1997;757(1):93-101.
1997: Grynspan F; Griffin W B; Mohan P S; Shea T B; Nixon R A
Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system.
Journal of neuroscience research 1997;48(3):181-91.
1996: Shiurba R A; Ishiguro K; Takahashi M; Sato K; Spooner E T; Mercken M; Yoshida R; Wheelock T R; Yanagawa H; Imahori K; Nixon R A
Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology.
Brain research 1996;737(1-2):119-32.
1996: Kampfl A; Posmantur R; Nixon R; Grynspan F; Zhao X; Liu S J; Newcomb J K; Clifton G L; Hayes R L
mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury.
Journal of neurochemistry 1996;67(4):1575-83.
1996: Sánchez I; Hassinger L; Paskevich P A; Shine H D; Nixon R A
Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(16):5095-105.
1996: Li J; Grynspan F; Berman S; Nixon R; Bursztajn S
Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord.
Journal of neurobiology 1996;30(2):177-91.
1996: Cataldo A M; Barnett J L; Mann D M; Nixon R A
Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome.
Journal of neuropathology and experimental neurology 1996;55(6):704-15.
1996: Shea T B; Spencer M J; Beermann M L; Cressman C M; Nixon R A
Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C.
Journal of neurochemistry 1996;66(4):1539-49.
1996: Didier M; Bursztajn S; Adamec E; Passani L; Nixon R A; Coyle J T; Wei J Y; Berman S A
DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(7):2238-50.
1996: Cataldo A M; Hamilton D J; Barnett J L; Paskevich P A; Nixon R A
Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(1):186-99.
1996: Cataldo A M; Hamilton D J; Barnett J L; Paskevich P A; Nixon R A
Abnormalities of the endosomal-lysosomal system in Alzheimer's disease: relationship to disease pathogenesis.
Advances in experimental medicine and biology 1996;389():271-80.
1995: Mercken M; Fischer I; Kosik K S; Nixon R A
Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(12):8259-67.
1995: Nixon R A; Cataldo A M
The endosomal-lysosomal system of neurons: new roles.
Trends in neurosciences 1995;18(11):489-96.
1995: Compaine A; Schein J D; Tabb J S; Mohan P S; Nixon R A
Limited proteolytic processing of the mature form of cathepsin D in human and mouse brain: postmortem stability of enzyme structure and activity.
Neurochemistry international 1995;27(4-5):385-96.
1995: Shea T B; Beermann M L; Nixon R A
Aluminum treatment of intact neuroblastoma cells alters neurofilament subunit phosphorylation, solubility, and proteolysis.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1995;26(1):1-14.
1995: Shea T B; Cressman C M; Spencer M J; Beermann M L; Nixon R A
Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C.
Journal of neurochemistry 1995;65(2):517-27.
1995: Mercken M; Grynspan F; Nixon R A
Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau.
FEBS letters 1995;368(1):10-4.
1995: Cressman C M; Mohan P S; Nixon R A; Shea T B
Proteolysis of protein kinase C: mM and microM calcium-requiring calpains have different abilities to generate, and degrade the free catalytic subunit, protein kinase M.
FEBS letters 1995;367(3):223-7.
1995: Cataldo A M; Barnett J L; Berman S A; Li J; Quarless S; Bursztajn S; Lippa C; Nixon R A
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.
Neuron 1995;14(3):671-80.
1995: Mohan P S; Nixon R A
Purification and properties of high molecular weight calpastatin from bovine brain.
Journal of neurochemistry 1995;64(2):859-66.
1995: Schwagerl A L; Mohan P S; Cataldo A M; Vonsattel J P; Kowall N W; Nixon R A
Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.
Journal of neurochemistry 1995;64(1):443-6.
1994: Nixon R A; Saito K I; Grynspan F; Griffin W R; Katayama S; Honda T; Mohan P S; Shea T B; Beermann M
Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease.
Annals of the New York Academy of Sciences 1994;747():77-91.
1994: Nixon R A; Lewis S E; Mercken M; Sihag R K
[32P]orthophosphate and [35S]methionine label separate pools of neurofilaments with markedly different axonal transport kinetics in mouse retinal ganglion cells in vivo.
Neurochemical research 1994;19(11):1445-53.
1994: Burke W J; Galvin N J; Chung H D; Stoff S A; Gillespie K N; Cataldo A M; Nixon R A
Degenerative changes in epinephrine tonic vasomotor neurons in Alzheimer's disease.
Brain research 1994;661(1-2):35-42.
1994: Sihag R K; Wang L W; Cataldo A M; Hamlin M; Cohen C M; Nixon R A
Evidence for the association of protein 4.1 immunoreactive forms with neurofibrillary tangles in Alzheimer's disease brains.
Brain research 1994;656(1):14-26.
1994: Nixon R A; Paskevich P A; Sihag R K; Thayer C Y
Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber.
The Journal of cell biology 1994;126(4):1031-46.
1994: Nixon R A; Cataldo A M
Free radicals, proteolysis, and the degeneration of neurons in Alzheimer disease: how essential is the beta-amyloid link?
Neurobiology of aging 1994;15(4):463-9; discussion 473.
1994: Cataldo A M; Hamilton D J; Nixon R A
Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease.
Brain research 1994;640(1-2):68-80.
1994: Shea T B; Beermann M L; Honda T; Nixon R A
Secretion of amyloid precursor protein and laminin by cultured astrocytes is influenced by culture conditions.
Journal of neuroscience research 1994;37(2):197-207.
1994: Nixon R A
Neuronal degenerative mechanisms as clues to pathogenesis and treatment of Alzheimer's disease.
Neurobiology of aging 1994;15 Suppl 2():S61-5.
1993: Nixon R A; Cataldo A M
The lysosomal system in neuronal cell death: a review.
Annals of the New York Academy of Sciences 1993;679():87-109.
1993: Saito K; Elce J S; Hamos J E; Nixon R A
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2628-32.
1993: Saito K; Nixon R A
Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human mu CANP and mCANP.
Neurochemical research 1993;18(2):231-3.
1993: Albert M; Jenike M; Nixon R; Nobel K
Thyrotropin response to thyrotropin-releasing hormone in patients with dementia of the Alzheimer type.
Biological psychiatry 1993;33(4):267-71.
1993: Leli U; Shea T B; Cataldo A; Hauser G; Grynspan F; Beermann M L; Liepkalns V A; Nixon R A; Parker P J
Differential expression and subcellular localization of protein kinase C alpha, beta, gamma, delta, and epsilon isoforms in SH-SY5Y neuroblastoma cells: modifications during differentiation.
Journal of neurochemistry 1993;60(1):289-98.
1993: Nixon R A
The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathobiology.
Brain pathology (Zurich, Switzerland) 1993;3(1):29-38.
1992: Nixon R A; Cataldo A M; Paskevich P A; Hamilton D J; Wheelock T R; Kanaley-Andrews L
The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis.
Annals of the New York Academy of Sciences 1992;674():65-88.
1992: Shea T B; Beermann M L; Leli U; Nixon R A
Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C.
Journal of neuroscience research 1992;33(3):398-407.
1992: Shea T B; Beermann M L; Nixon R A; Fischer I
Microtubule-associated protein tau is required for axonal neurite elaboration by neuroblastoma cells.
Journal of neuroscience research 1992;32(3):363-74.
1992: Takeuchi K H; Saito K I; Nixon R A
Immunoassay and activity of calcium-activated neutral proteinase (mCANP): distribution in soluble and membrane-associated fractions in human and mouse brain.
Journal of neurochemistry 1992;58(4):1526-32.
1992: Leli U; Cataldo A; Shea T B; Nixon R A; Hauser G
Distinct mechanisms of differentiation of SH-SY5Y neuroblastoma cells by protein kinase C activators and inhibitors.
Journal of neurochemistry 1992;58(4):1191-8.
1992: Shea T B; Beermann M L; Nixon R A
Aluminum alters the electrophoretic properties of neurofilament proteins: role of phosphorylation state.
Journal of neurochemistry 1992;58(2):542-7.
1992: Shea T B; Beermann M L; Nixon R A
Sequential effects of astroglial-derived factors on neurite outgrowth: initiation by protease inhibitors and potentiation by extracellular matrix components.
Journal of neuroscience research 1992;31(2):309-17.
1992: Nixon R A
Slow axonal transport.
Current opinion in cell biology 1992;4(1):8-14.
1992: Nixon R A; Shea T B
Dynamics of neuronal intermediate filaments: a developmental perspective.
Cell motility and the cytoskeleton 1992;22(2):81-91.
1991: Cataldo A M; Paskevich P A; Kominami E; Nixon R A
Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):10998-1002.
1991: Nixon R A; Sihag R K
Neurofilament phosphorylation: a new look at regulation and function.
Trends in neurosciences 1991;14(11):501-6.
1991: Sihag R K; Nixon R A
Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport.
The Journal of biological chemistry 1991;266(28):18861-7.
1991: Shea T B; Beermann M L; Nixon R A
Multiple proteases regulate neurite outgrowth in NB2a/dl neuroblastoma cells.
Journal of neurochemistry 1991;56(3):842-51.
1990: Nixon R A; Clarke J F; Logvinenko K B; Tan M K; Hoult M; Grynspan F
Aluminum inhibits calpain-mediated proteolysis and induces human neurofilament proteins to form protease-resistant high molecular weight complexes.
Journal of neurochemistry 1990;55(6):1950-9.
1990: Shea T B; Sihag R K; Nixon R A
Dynamics of phosphorylation and assembly of the high molecular weight neurofilament subunit in NB2a/d1 neuroblastoma.
Journal of neurochemistry 1990;55(5):1784-92.
1990: Cataldo A M; Nixon R A
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3861-5.
1990: Cataldo A M; Thayer C Y; Bird E D; Wheelock T R; Nixon R A
Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin.
Brain research 1990;513(2):181-92.
1990: Canoso R T; de Oliveira R M; Nixon R A
Neuroleptic-associated autoantibodies. A prevalence study.
Biological psychiatry 1990;27(8):863-70.
1990: Sihag R K; Nixon R A
Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases.
The Journal of biological chemistry 1990;265(7):4166-71.
1990: Shea T B; Beermann M L; Nixon R A
Post-translational modification of alpha-tubulin by acetylation and detyrosination in NB2a/d1 neuroblastoma cells.
Brain research. Developmental brain research 1990;51(2):195-204.
1990: Nixon R A; Fischer I; Lewis S E
Synthesis, axonal transport, and turnover of the high molecular weight microtubule-associated protein MAP 1A in mouse retinal ganglion cells: tubulin and MAP 1A display distinct transport kinetics.
The Journal of cell biology 1990;110(2):437-48.
1989: Shea T B; Beermann M L; Nixon R A
Appearance and localization of phosphorylated variants of the high molecular weight neurofilament protein in NB2a/d1 cytoskeletons during differentiation.
Brain research. Developmental brain research 1989;50(1):142-6.
1989: Falk W E; Rosenbaum J F; Otto M W; Zusky P M; Weilburg J B; Nixon R A
Fluoxetine versus trazodone in depressed geriatric patients.
Journal of geriatric psychiatry and neurology 1989;2(4):208-14.
1989: Shea T B; Clarke J F; Wheelock T R; Paskevich P A; Nixon R A
Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/dl neuroblastoma.
Brain research 1989;492(1-2):53-64.
1989: Nixon R A; Lewis S E; Dahl D; Marotta C A; Drager U C
Early posttranslational modifications of the three neurofilament subunits in mouse retinal ganglion cells: neuronal sites and time course in relation to subunit polymerization and axonal transport.
Brain research. Molecular brain research 1989;5(2):93-108.
1989: Sihag R K; Nixon R A
In vivo phosphorylation of distinct domains of the 70-kilodalton neurofilament subunit involves different protein kinases.
The Journal of biological chemistry 1989;264(1):457-64.
1989: Nixon R A
Calcium-activated neutral proteinases as regulators of cellular function. Implications for Alzheimer's disease pathogenesis.
Annals of the New York Academy of Sciences 1989;568():198-208.
1988: Lewis S E; Nixon R A
Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: characterization and evidence for their differential association with stationary and moving neurofilaments.
The Journal of cell biology 1988;107(6 Pt 2):2689-701.
1988: Pope H G; McElroy S L; Nixon R A
Possible synergism between fluoxetine and lithium in refractory depression.
The American journal of psychiatry 1988;145(10):1292-4.
1988: Shea T B; Majocha R E; Marotta C A; Nixon R A
Soluble, phosphorylated forms of the high molecular weight neurofilament protein in perikarya of cultured neuronal cells.
Neuroscience letters 1988;92(3):291-7.
1988: Shea T B; Sihag R K; Nixon R A
Neurofilament triplet proteins of NB2a/d1 neuroblastoma: posttranslational modification and incorporation into the cytoskeleton during differentiation.
Brain research 1988;471(1):97-109.
1988: Sihag R K; Jeng A Y; Nixon R A
Phosphorylation of neurofilament proteins by protein kinase C.
FEBS letters 1988;233(1):181-5.
1988: Shea T B; Nixon R A
Differential distribution of vimentin and neurofilament protein immunoreactivity in NB2a/d1 neuroblastoma cells following neurite retraction distinguishes two separate intermediate filament systems.
Brain research 1988;469(1-2):298-302.
1987: Nixon R A; Lewis S E; Marotta C A
Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(4):1145-58.
1987: Nixon R A; Lewis S E
Phosphorylation and dephosphorylation of neurofilament proteins in retinal ganglion cell neurons in vivo.
Advances in experimental medicine and biology 1987;221():167-86.
1986: Nixon R A; Lewis S E
Differential turnover of phosphate groups on neurofilament subunits in mammalian neurons in vivo.
The Journal of biological chemistry 1986;261(35):16298-301.
1986: Zubenko G S; Marquis J K; Volicer L; Direnfeld L K; Langlais P J; Nixon R A
Cerebrospinal fluid levels of angiotensin-converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: a correlative study.
Biological psychiatry 1986;21(14):1365-81.
1986: Vitto A; Nixon R A
Calcium-activated neutral proteinase of human brain: subunit structure and enzymatic properties of multiple molecular forms.
Journal of neurochemistry 1986;47(4):1039-51.
1986: Fleming N; Nixon R A
A versatile transition metal salt reaction for a wide range of common biochemical reagents: an instantaneous and quantifiable color test.
Analytical biochemistry 1986;154(2):691-701.
1986: Nixon R A
Fodrin degradation by calcium-activated neutral proteinase (CANP) in retinal ganglion cell neurons and optic glia: preferential localization of CANP activities in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(5):1264-71.
1986: Nixon R A; Quackenbush R; Vitto A
Multiple calcium-activated neutral proteinases (CANP) in mouse retinal ganglion cell neurons: specificities for endogenous neuronal substrates and comparison to purified brain CANP.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(5):1252-63.
1986: Nixon R A; Logvinenko K B
Multiple fates of newly synthesized neurofilament proteins: evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons.
The Journal of cell biology 1986;102(2):647-59.
1986: Pope H G; Hudson J I; Nixon R A; Herridge P L
The epidemiology of ipecac abuse.
The New England journal of medicine 1986;314(4):245-6.
1985: Zubenko G S; Nixon R A
Captopril and teprotide as discriminators of angiotensin-converting enzyme activity in brain tissue.
Neuroscience letters 1985;60(1):33-7.
1985: Zubenko G S; Volicer L; Direnfeld L K; Freeman M; Langlais P J; Nixon R A
Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy.
Brain research 1985;328(2):215-21.
1984: Nixon R A; Marotta C A
Degradation of neurofilament proteins by purified human brain cathepsin D.
Journal of neurochemistry 1984;43(2):507-16.
1984: Pope A; Nixon R A
Proteases of human brain.
Neurochemical research 1984;9(3):291-323.
1984: Zubenko G S; Nixon R A
Mood-elevating effect of captopril in depressed patients.
The American journal of psychiatry 1984;141(1):110-1.
1983: Nixon R A; Brown B A; Marotta C A
Limited proteolytic modification of a neurofilament protein involves a proteinase activated by endogenous levels of calcium.
Brain research 1983;275(2):384-8.
1982: Brown B A; Nixon R A; Marotta C A
Posttranslational processing of alpha-tubulin during axoplasmic transport in CNS axons.
The Journal of cell biology 1982;94(1):159-64.
1982: Nixon R A; Brown B A; Marotta C A
Posttranslational modification of a neurofilament protein during axoplasmic transport: implications for regional specialization of CNS axons.
The Journal of cell biology 1982;94(1):150-8.
1982: Nixon R A; Rothman J S; Chin W
Demeclocycline in the prophylaxis of self-induced water intoxication.
The American journal of psychiatry 1982;139(6):828-30.
1982: Nixon R A
Increased axonal proteolysis in myelin-deficient mutant mice.
Science (New York, N.Y.) 1982;215(4535):999-1001.
1981: Pope A; Amelotte J A; Belfer H; Nixon R A
Protease activities in normal and schizophrenic human prefrontal cortex and white matter.
Neurochemical research 1981;6(10):1043-52.
1981: Brown B A; Nixon R A; Strocchi P; Marotta C A
Characterization and comparison of neurofilament proteins from rat and mouse CNS.
Journal of neurochemistry 1981;36(1):143-53.
1980: Nixon R A
Protein degradation in the mouse visual system. I. Degradation of axonally transported and retinal proteins.
Brain research 1980;200(1):69-83.
1978: LaVail J H; Nixon R A; Sidman R L
Genetic control of retinal ganglion cell projections.
The Journal of comparative neurology 1978;182(3):399-421.
1978: Nixon R A
Quinine sulfate for pain in the Guillain-Barré syndrome.
Annals of neurology 1978;4(4):386-7.
1977: Nixon R A; Karnovsky M L
Uptake and metabolism of intraventricularly administered piperidine and its effects on sleep and wakefulness in the rat.
Brain research 1977;134(3):501-11.
1976: Nixon R A; Suva M; Wolf M K
Neurotoxicity of a non-metabolizable amino acid, 1-aminocyclopentane-1-carboxylic acid: antagonism by amino acids in cultures of cerebellum.
Journal of neurochemistry 1976;27(1):245-51.
1976: Nixon R A
Neurotoxicity of a non-metabolizable amino acid, 1-aminocyclopentane-1-carboxylic acid: regional protein levels and lipid composition of nervous tissue.
Journal of neurochemistry 1976;27(1):237-44.
1976: Nixon R A
Neurotoxicity of a non-metabolizable amino acid, 1 -aminocyclopentane-1-carboxylic acid (ACPC): ACPC transport mechanisms in tissues.
Biochemical pharmacology 1976;25(6):726-9.
1972: Nixon R
Volatile amines in mouse brain: a radioassay with picogram sensitivity.
Analytical biochemistry 1972;48(2):460-70.
1971: Nixon R; Kanfer J N
Comparison of cerebral sphingolipid metabolism in vivo in "quaking" and normal mice.
Life sciences. Pt. 2: Biochemistry, general and molecular biology 1971;10(2):71-9.

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