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Ward Anthony Pedersen

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Ward Anthony Pedersen; Pamela J McMillan; J Jacob Kulstad; James B Leverenz; Suzanne Craft; Gleb Haynatzki
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.
Ward Anthony Pedersen; Emily R Flynn
Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease.
Malgorzata Chalimoniuk; Kelley King-Pospisil; Ward Anthony Pedersen; Andrzej Malecki; Edward Wylegala; Mark P Mattson; Bernhard Hennig; Michal J Toborek
Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism.

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All Publications

2006: Ward Anthony Pedersen; Pamela J McMillan; J Jacob Kulstad; James B Leverenz; Suzanne Craft; Gleb Haynatzki
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.
Experimental neurology 2006;199(2):265-73.
2004: Ward Anthony Pedersen; Emily R Flynn
Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease.
Neurobiology of disease 2004;17(3):500-6.
2004: Malgorzata Chalimoniuk; Kelley King-Pospisil; Ward Anthony Pedersen; Andrzej Malecki; Edward Wylegala; Mark P Mattson; Bernhard Hennig; Michal J Toborek
Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism.
Journal of neurochemistry 2004;90(3):629-36.
2004: Roy G Cutler; Jeremiah F Kelly; Kristin Storie; Ward Anthony Pedersen; Anita Tammara; Kimmo J Hatanpaa; Juan C Troncoso; Mark P Mattson
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2070-5.
2002: Roy G Cutler; Ward Anthony Pedersen; Simonetta Camandola; Jeffrey rothstein; Mark P Mattson
Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis.
Annals of neurology 2002;52(4):448-57.
2002: Ward Anthony Pedersen; Sic L Chan; Haiyan Zhu; Lilanie A Abdur-Rahman; Joseph M Verdi; Mark P Mattson
Numb isoforms containing a short PTB domain promote neurotrophic factor-induced differentiation and neurotrophic factor withdrawal-induced death of PC12 Cells.
Journal of neurochemistry 2002;82(4):976-86.
2002: Smita Kittur; Skuntala Wilasrusmee; Ward Anthony Pedersen; Mark P Mattson; Karen Straube-West; Chumpon Wilasrusmee; Burk Lubelt; Dilip S Kittur
Neurotrophic and neuroprotective effects of milk thistle (Silybum marianum) on neurons in culture.
Journal of molecular neuroscience : MN 2002;18(3):265-9.
2002: Inna I Kruman; T Kumaravel; Althaf Lohani; Ward Anthony Pedersen; Roy G Cutler; Yuri Kruman; Norman Haughey; Jaewon Lee; Michele Evans; Mark P Mattson
Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1752-62.
2002: Peter J Van Ess; Ward Anthony Pedersen; Carsten Culmsee; Mark P Mattson; Robert A Blouin
Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease.
Journal of neurochemistry 2002;80(4):571-8.
2002: Ward Anthony Pedersen; Ruiqian Wan; Peisu Zhang; Mark P Mattson
Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(2):404-12.
2002: Sic L Chan; Ward Anthony Pedersen; Hiayan Zhu; Mark P Mattson
Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease.
Neuromolecular medicine 2002;1(1):55-67.
2001: Ward Anthony Pedersen; Ruiqian Wan; Mark P Mattson
Impact of aging on stress-responsive neuroendocrine systems.
Mechanisms of ageing and development 2001;122(9):963-83.
2001: Ward Anthony Pedersen; Deanna L McCullers; Carsten Culmsee; Norman Haughey; James P Herman; Mark P Mattson
Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease.
Neurobiology of disease 2001;8(3):492-503.
2001: Mark P Mattson; WENZHEN DUAN; Ward Anthony Pedersen; Carsten Culmsee
Neurodegenerative disorders and ischemic brain diseases.
Apoptosis : an international journal on programmed cell death 2001;6(1-2):69-81.
2000: Ward Anthony Pedersen; H Luo; Inna I Kruman; Edward J Kasarskis; Mark P Mattson
The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(7):913-24.
2000: Ward Anthony Pedersen; Sic L Chan; Mark P Mattson
A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal.
Journal of neurochemistry 2000;74(4):1426-33.
1999: Inna I Kruman; Ward Anthony Pedersen; Joe E Springer; Mark P Mattson
ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis.
Experimental neurology 1999;160(1):28-39.
1999: Ward Anthony Pedersen; Carsten Culmsee; D Ziegler; James P Herman; Mark P Mattson
Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease.
Journal of molecular neuroscience : MN 1999;13(1-2):159-65.
1999: Ward Anthony Pedersen; Mark P Mattson
No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice.
Brain research 1999;833(1):117-20.
1999: Jeff Keller; KB Hanni; Ward Anthony Pedersen; Neil R Cashman; Mark P Mattson; S Prasad Gabbita; V Friebe; William R Markesbery
Opposing actions of native and oxidized lipoprotein on motor neuron-like cells.
Experimental neurology 1999;157(1):202-10.
1999: Mark P Mattson; Ward Anthony Pedersen; WENZHEN DUAN; Carsten Culmsee; Simonetta Camandola
Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.
Annals of the New York Academy of Sciences 1999;893():154-75.
1999: Ward Anthony Pedersen; Neil R Cashman; Mark P Mattson
The lipid peroxidation product 4-hydroxynonenal impairs glutamate and glucose transport and choline acetyltransferase activity in NSC-19 motor neuron cells.
Experimental neurology 1999;155(1):1-10.
1998: Mark P Mattson; Ward Anthony Pedersen
Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(7-8):737-53.
1998: Ward Anthony Pedersen; W Fu; Jeff Keller; William R Markesbery; S Appel; R G Smith; Edward J Kasarskis; Mark P Mattson
Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients.
Annals of neurology 1998;44(5):819-24.
1998: Mark P Mattson; Qing Guo; K Furukawa; Ward Anthony Pedersen
Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.
Journal of neurochemistry 1998;70(1):1-14.
1997: Ward Anthony Pedersen; Jan Krzysztof Blusztajn
Characterization of the acetylcholine-reducing effect of the amyloid-beta peptide in mouse SN56 cells.
Neuroscience letters 1997;239(2-3):77-80.
1997: Ward Anthony Pedersen; Qing Guo; B K Hartman; Mark P Mattson
Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1.
The Journal of biological chemistry 1997;272(36):22397-400.
1996: Ward Anthony Pedersen; M A Kloczewiak; Jan Krzysztof Blusztajn
Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):8068-71.
1995: Ward Anthony Pedersen; Brygida Berse; U Schüler; B H Wainer; Jan Krzysztof Blusztajn
All-trans- and 9-cis-retinoic acid enhance the cholinergic properties of a murine septal cell line: evidence that the effects are mediated by activation of retinoic acid receptor-alpha.
Journal of neurochemistry 1995;65(1):50-8.
1994: P L Hudson; Ward Anthony Pedersen; W S Saltsman; Mordechai Liscovitch; David T MacLaughlin; Patricia K Donahoe; Jan Krzysztof Blusztajn
Modulation by sphingolipids of calcium signals evoked by epidermal growth factor.
The Journal of biological chemistry 1994;269(34):21885-90.
1993: Ward Anthony Pedersen; Lawrence E Becker; Herman Yeger
Expression and distribution of peripherin protein in human neuroblastoma cell lines.
International journal of cancer. Journal international du cancer 1993;53(3):463-70.