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Rebecca Rylett

Research Profile

Chemicals & Drugs

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TOP 3
Jordan T Newington; Tim Rappon; Rebecca Rylett; Daisy Y L Wong; Shawn Albers; Robert C Cumming
Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.
Leah K Cuddy; Stephen S G Ferguson; Alexis C Gordon; Ewa Jaworski; Stefanie A G Black; Rebecca Rylett
Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking.
Fabiana A Caetano; Flavio H Beraldo; Glaucia N M Hajj; Andre L Guimaraes; Sofia Jurgensen; Ana Paula Wasilewska-Sampaio; Pedro H F Hirata; Ivana Souza; Cleiton F Machado; Daisy Y L Wong; Fernanda G De Felice; Sergio T Ferreira; Vania F Prado; Rebecca Rylett; Vilma R Martins; Marco Prado
Amyloid-beta oligomers increase the localization of prion protein at the cell surface.

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All Publications

2012: Jordan T Newington; Tim Rappon; Rebecca Rylett; Daisy Y L Wong; Shawn Albers; Robert C Cumming
Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production.
The Journal of biological chemistry 2012;287(44):37245-58.
2012: Leah K Cuddy; Stephen S G Ferguson; Alexis C Gordon; Ewa Jaworski; Stefanie A G Black; Rebecca Rylett
Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(16):5573-84.
2011: Fabiana A Caetano; Flavio H Beraldo; Glaucia N M Hajj; Andre L Guimaraes; Sofia Jurgensen; Ana Paula Wasilewska-Sampaio; Pedro H F Hirata; Ivana Souza; Cleiton F Machado; Daisy Y L Wong; Fernanda G De Felice; Sergio T Ferreira; Vania F Prado; Rebecca Rylett; Vilma R Martins; Marco Prado
Amyloid-beta oligomers increase the localization of prion protein at the cell surface.
Journal of neurochemistry 2011;117(3):538-53.
2010: Stefanie A G Black; Fabiola Ribeiro; Stephen S G Ferguson; Rebecca Rylett
Rapid, transient effects of the protein kinase C activator phorbol 12-myristate 13-acetate on activity and trafficking of the rat high-affinity choline transporter.
Neuroscience 2010;167(3):765-73.
2009: Kirk F Young; Stephen H Pasternak; Rebecca Rylett
Oligomeric aggregates of amyloid beta peptide 1-42 activate ERK/MAPK in SH-SY5Y cells via the alpha7 nicotinic receptor.
Neurochemistry international 2009;55(8):796-801.
2009: Braulio M de Castro; Xavier De Jaeger; Cristina Martins-Silva; Ricardo D F Lima; Ernani Amaral; Cristiane Menezes; Patricia Lima; Cintia M L Neves; Rita G Pires; Thomas W Gould; Ian Welch; Christopher Kushmerick; Cristina Guatimosim; Ivan Izquierdo; Martin Cammarota; Rebecca Rylett; Marcus V Gomez; Marc G Caron; Ronald W Oppenheim; Marco Prado; Vania F Prado
The vesicular acetylcholine transporter is required for neuromuscular development and function.
Molecular and cellular biology 2009;29(19):5238-50.
2009: Ventzislava A Hristova; Steven A Beasley; Rebecca Rylett; Gary Shaw
Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin.
The Journal of biological chemistry 2009;284(22):14978-86.
2009: Kenneth M Tichauer; Daisy Y L Wong; Jennifer Hadway; Rebecca Rylett; Ting-Yim Lee; Keith St Lawrence
Assessing the severity of perinatal hypoxia-ischemia in piglets using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen.
Pediatric research 2009;65(3):301-6.
2008: Metta Pinthong; Stefanie A G Black; Fabiola Ribeiro; Chumpol Pholpramool; Stephen S G Ferguson; Rebecca Rylett
Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite.
Molecular pharmacology 2008;73(3):801-12.
2007: Fabiola Ribeiro; Metta Pinthong; Stefanie A G Black; Alexis C Gordon; Vania F Prado; Marco Prado; Rebecca Rylett; Stephen S G Ferguson
Regulated recycling and plasma membrane recruitment of the high-affinity choline transporter.
The European journal of neuroscience 2007;26(12):3437-48.
2007: Sandeep K Gill; Margaret Ishak; Tomas Dobransky; Vahram Haroutunian; Kenneth L Davis; Rebecca Rylett
82-kDa choline acetyltransferase is in nuclei of cholinergic neurons in human CNS and altered in aging and Alzheimer disease.
Neurobiology of aging 2007;28(7):1028-40.
2006: Ae-Ri Kim; Rebecca Rylett; Brian H Shilton
Substrate binding and catalytic mechanism of human choline acetyltransferase.
Biochemistry 2006;45(49):14621-31.
2006: Fabiola Ribeiro; Stefanie A G Black; Vania F Prado; Rebecca Rylett; Stephen S G Ferguson; Marco Prado
The "ins" and "outs" of the high-affinity choline transporter CHT1.
Journal of neurochemistry 2006;97(1):1-12.
2005: Sandeep K Gill; Margaret Ishak; Rebecca Rylett
Exposure of nuclear antigens in formalin-fixed, paraffin-embedded necropsy human spinal cord tissue: detection of NeuN.
Journal of neuroscience methods 2005;148(1):26-35.
2005: Tomas Dobransky; Rebecca Rylett
A model for dynamic regulation of choline acetyltransferase by phosphorylation.
Journal of neurochemistry 2005;95(2):305-13.
2005: Ae-Ri Kim; Tomas Dobransky; Rebecca Rylett; Brian H Shilton
Surface-entropy reduction used in the crystallization of human choline acetyltransferase.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 9):1306-10.
2005: Fabiola Ribeiro; Stefanie A G Black; Sean P Cregan; Vania F Prado; Marco Prado; Rebecca Rylett; Stephen S G Ferguson
Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif.
Journal of neurochemistry 2005;94(1):86-96.
2005: Ae-Ri Kim; Amanda Doherty-Kirby; Gilles Lajoie; Rebecca Rylett; Brian H Shilton
Two methods for large-scale purification of recombinant human choline acetyltransferase.
Protein expression and purification 2005;40(1):107-17.
2004: Tomas Dobransky; Amanda Doherty-Kirby; Ae-Ri Kim; Dyanne Brewer; Gilles Lajoie; Rebecca Rylett
Protein kinase C isoforms differentially phosphorylate human choline acetyltransferase regulating its catalytic activity.
The Journal of biological chemistry 2004;279(50):52059-68.
2003: Bettina E Kalisch; C Shaun Demeris; Margaret Ishak; Rebecca Rylett
Modulation of nerve growth factor-induced activation of MAP kinase in PC12 cells by inhibitors of nitric oxide synthase.
Journal of neurochemistry 2003;87(6):1321-32.
2003: Fabiola Ribeiro; Juliana Alves-Silva; Walter Volknandt; Cristina Martins-Silva; H Mahmud; Alexander Wilhelm; Marcus V Gomez; Rebecca Rylett; Stephen S G Ferguson; Vania F Prado; Marco Prado
The hemicholinium-3 sensitive high affinity choline transporter is internalized by clathrin-mediated endocytosis and is present in endosomes and synaptic vesicles.
Journal of neurochemistry 2003;87(1):136-46.
2003: Sandeep K Gill; Moshmi Bhattacharya; Stephen S G Ferguson; Rebecca Rylett
Identification of a novel nuclear localization signal common to 69- and 82-kDa human choline acetyltransferase.
The Journal of biological chemistry 2003;278(22):20217-24.
2003: Tomas Dobransky; Rebecca Rylett
Functional regulation of choline acetyltransferase by phosphorylation.
Neurochemical research 2003;28(3-4):537-42.
2003: Tomas Dobransky; Dyanne Brewer; Gilles Lajoie; Rebecca Rylett
Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42.
The Journal of biological chemistry 2003;278(8):5883-93.
2002: Moshmi Bhattacharya; Pieter H Anborgh; Andy V Babwah; Lianne B Dale; Tomas Dobransky; Jeffery L Benovic; Ross D Feldman; Joseph M Verdi; Rebecca Rylett; Stephen S G Ferguson
Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization.
Nature cell biology 2002;4(8):547-55.
2002: Bettina E Kalisch; Nicholas A Bock; Wanda L Davis; Rebecca Rylett
Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline acetyltransferase expression in PC12 cells.
Journal of neurochemistry 2002;81(3):624-35.
2002: Jacqueline C Baskey; Bettina E Kalisch; Wanda L Davis; Susan O Meakin; Rebecca Rylett
PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.
Journal of neurochemistry 2002;80(3):501-11.
2001: Tomas Dobransky; Wanda L Davis; Rebecca Rylett
Functional characterization of phosphorylation of 69-kDa human choline acetyltransferase at serine 440 by protein kinase C.
The Journal of biological chemistry 2001;276(25):22244-50.
2000: Karmen M Krol; keith crutcher; Bettina E Kalisch; Rebecca Rylett; Michael D Kawaja
Absence of p75(NTR) expression reduces nerve growth factor immunolocalization in cholinergic septal neurons.
The Journal of comparative neurology 2000;427(1):54-66.
2000: Tomas Dobransky; Wanda L Davis; G H Xiao; Rebecca Rylett
Expression, purification and characterization of recombinant human choline acetyltransferase: phosphorylation of the enzyme regulates catalytic activity.
The Biochemical journal 2000;349(Pt 1):141-51.
1999: M C Resendes; Tomas Dobransky; Stephen S G Ferguson; Rebecca Rylett
Nuclear localization of the 82-kDa form of human choline acetyltransferase.
The Journal of biological chemistry 1999;274(27):19417-21.
1998: JL Pongrac; Rebecca Rylett
NGF-induction of the expression of ChAT mRNA in PC12 cells and primary cultures of embryonic rat basal forebrain.
Brain research. Molecular brain research 1998;62(1):25-34.
1998: JL Pongrac; Rebecca Rylett
Optimization of serum-free culture conditions for growth of embryonic rat cholinergic basal forebrain neurons.
Journal of neuroscience methods 1998;84(1-2):69-76.
1998: JL Pongrac; Rebecca Rylett
Molecular mechanisms regulating NGF-mediated enhancement of cholinergic neuronal phenotype: c-fos trans-activation of the choline acetyltransferase gene.
Journal of molecular neuroscience : MN 1998;11(1):79-93.
1997: Marlies Knipper; Rebecca Rylett
A new twist in an old story: the role for crosstalk of neuronal and trophic activity.
Neurochemistry international 1997;31(5):659-76.
1997: Robert Bartha; Peter C Williamson; Dick J Drost; Ashok K Malla; Thomas J Carr; Leonardo Cortese; G Canaran; Rebecca Rylett; Richard W J Neufeld
Measurement of glutamate and glutamine in the medial prefrontal cortex of never-treated schizophrenic patients and healthy controls by proton magnetic resonance spectroscopy.
Archives of general psychiatry 1997;54(10):959-65.
1997: L J Cooke; Rebecca Rylett
Inhibitors of serine/threonine phosphatases increase membrane-bound choline acetyltransferase activity and enhance acetylcholine synthesis.
Brain research 1997;751(2):232-8.
1996: J L Pongrac; Rebecca Rylett
Differential effects of nerve growth factor on expression of choline acetyltransferase and sodium-coupled choline transport in basal forebrain cholinergic neurons in culture.
Journal of neurochemistry 1996;66(2):804-10.
1996: Jeffrey Stanley; Peter C Williamson; Dick J Drost; Rebecca Rylett; Thomas J Carr; Ashok K Malla; R Terry Thompson
An in vivo proton magnetic resonance spectroscopy study of schizophrenia patients.
Schizophrenia bulletin 1996;22(4):597-609.
1996: Rebecca Rylett; S A Walters; W Davis
Identification and partial characterization of the high-affinity choline carrier from rat brain striatum.
Brain research. Molecular brain research 1996;35(1-2):354-8.
1995: Jeffrey Stanley; Peter C Williamson; Dick J Drost; Thomas J Carr; Rebecca Rylett; Ashok K Malla; R Terry Thompson
An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy.
Archives of general psychiatry 1995;52(5):399-406.
1995: Gail M Lawrance; Rebecca Rylett; Peter M Richardson; Robert J Dunn; Kimberly E Dow; Richard J Riopelle
Differentiation effects of ciliary neurotrophic factor on human neuroblastoma cells.
Journal of neurochemistry 1995;64(4):1483-90.
1994: Marlies Knipper; L Stan Leung; D Zhao; Rebecca Rylett
Short-term modulation of glutamatergic synapses in adult rat hippocampus by NGF.
Neuroreport 1994;5(18):2433-6.
1994: Rebecca Rylett; L R Williams
Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS.
Trends in neurosciences 1994;17(11):486-90.
1994: K W Jones; Rebecca Rylett; James R Hammond
Effect of cellular differentiation on nucleoside transport in human neuroblastoma cells.
Brain research 1994;660(1):104-12.
1994: Stephen S G Ferguson; Rebecca Rylett; B Collier
Regulation of rat brain synaptosomal [3H]hemicholinium-3 binding and [3H]choline transport sites following exposure to choline mustard aziridinium ion.
Journal of neurochemistry 1994;63(4):1328-37.
1994: Jeffrey Stanley; Peter C Williamson; Dick J Drost; Thomas J Carr; Rebecca Rylett; S Morrison-Stewart; R Terry Thompson
Membrane phospholipid metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study.
Schizophrenia research 1994;13(3):209-15.
1993: B M Schmidt; Rebecca Rylett
Phosphorylation of rat brain choline acetyltransferase and its relationship to enzyme activity.
Journal of neurochemistry 1993;61(5):1774-81.
1993: Rebecca Rylett; W Davis; S A Walters
Modulation of high-affinity choline carrier activity following incubation of rat hippocampal synaptosomes with hemicholinium-3.
Brain research 1993;626(1-2):184-9.
1993: Rebecca Rylett; S Goddard; A Lambros
Regulation of expression of cholinergic neuronal phenotypic markers in neuroblastoma LA-N-2.
Journal of neurochemistry 1993;61(4):1388-97.
1993: Rebecca Rylett; S Goddard; B M Schmidt; L R Williams
Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(9):3956-63.
1993: B M Schmidt; Rebecca Rylett
Basal synthesis of acetylcholine in hippocampal synaptosomes is not dependent upon membrane-bound choline acetyltransferase activity.
Neuroscience 1993;54(3):649-56.
1993: GL Dunbar; Rebecca Rylett; B M Schmidt; R C Sinclair; L R Williams
Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats.
Brain research 1993;604(1-2):266-72.
1993: L R Williams; Rebecca Rylett; Donald Ingram; James A Joseph; H C Moises; A H Tang; R F Mervis
Nerve growth factor affects the cholinergic neurochemistry and behavior of aged rats.
Progress in brain research 1993;98():251-6.
1993: Rebecca Rylett; B M Schmidt
Regulation of the synthesis of acetylcholine.
Progress in brain research 1993;98():161-6.
1991: L R Williams; Rebecca Rylett; H C Moises; A H Tang
Exogenous NGF affects cholinergic transmitter function and Y-maze behavior in aged Fischer 344 male rats.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1991;18(3 Suppl):403-7.
1990: L R Williams; Rebecca Rylett
Exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of Fisher 344 male rats.
Journal of neurochemistry 1990;55(3):1042-9.
1990: J C Baskey; E H Colhoun; Rebecca Rylett
Cholinergic but not GABAergic neuronal markers are decreased in primary neuronal cultures treated with choline mustard.
Brain research 1990;519(1-2):209-16.
1990: Rebecca Rylett; S A Walters
Uptake and metabolism of [3H]choline mustard by cholinergic nerve terminals from rat brain.
Neuroscience 1990;36(2):483-9.
1990: Rebecca Rylett
Solubilization and partial characterization of [3H]choline mustard-labeled high-affinity choline carrier from presynaptic plasma membrane of Torpedo electric organ.
Journal of molecular neuroscience : MN 1990;2(2):85-90.
1989: Rebecca Rylett
Synaptosomal "membrane-bound" choline acetyltransferase is most sensitive to inhibition by choline mustard.
Journal of neurochemistry 1989;52(3):869-75.
1988: Rebecca Rylett
Affinity labelling and identification of the high-affinity choline carrier from synaptic membranes of Torpedo electromotor nerve terminals with [3H]choline mustard.
Journal of neurochemistry 1988;51(6):1942-5.
1986: E H Colhoun; L A Myles; Rebecca Rylett
An attempt to produce cholinergic hypofunction in rat brain using choline mustard aziridinium ion: neurochemical and histological parameters.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1986;13(4 Suppl):517-20.
1986: Rebecca Rylett
Choline mustard: an irreversible ligand for use in studies of choline transport mechanisms at the cholinergic nerve terminal.
Canadian journal of physiology and pharmacology 1986;64(3):334-40.
1985: Rebecca Rylett; E H Colhoun
Studies on the alkylation of choline acetyltransferase by choline mustard aziridinium ion.
Journal of neurochemistry 1985;44(6):1951-4.
1985: Harold Merskey; W T Blume; E H Colhoun; M Fisman; A J Fox; H Fox; vladimir hachinski; V A Kral; Rebecca Rylett; R Smith
Correlative studies in Alzheimer's disease.
Progress in neuro-psychopharmacology & biological psychiatry 1985;9(5-6):509-14.
1984: Rebecca Rylett; E H Colhoun
An evaluation of irreversible inhibition of synaptosomal high-affinity choline transport by choline mustard aziridinium ion.
Journal of neurochemistry 1984;43(3):787-94.
1984: H P Rang; Rebecca Rylett
The interaction between hexamethonium and tubocurarine on the rat neuromuscular junction.
British journal of pharmacology 1984;81(3):519-31.
1983: Rebecca Rylett; Melvyn Ball; E H Colhoun
Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease.
Brain research 1983;289(1-2):169-75.