Rebecca Rylett

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TOP 3
Young Kirk F; Pasternak Stephen H; Rylett R Jane
Oligomeric aggregates of amyloid beta peptide 1-42 activate ERK/MAPK in SH-SY5Y cells via the alpha7 nicotinic receptor.
de Castro Braulio M; De Jaeger Xavier; Martins-Silva Cristina; Lima Ricardo D F; Amaral Ernani; Menezes Cristiane; Lima Patricia; Neves Cintia M L; Pires Rita G; Gould Thomas W; Welch Ian; Kushmerick Christopher; Guatimosim Cristina; Izquierdo Ivan; Cammarota Martin; Rylett R Jane; Gomez Marcus V; Caron Marc G; Oppenheim Ronald W; Prado Marco A M; Prado Vania F
The vesicular acetylcholine transporter is required for neuromuscular development and function.
Hristova Ventzislava A; Beasley Steven A; Rylett R Jane; Shaw Gary S
Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin.

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2009: Young Kirk F; Pasternak Stephen H; Rylett R Jane
Oligomeric aggregates of amyloid beta peptide 1-42 activate ERK/MAPK in SH-SY5Y cells via the alpha7 nicotinic receptor.
Neurochemistry international 2009;55(8):796-801.
2009: de Castro Braulio M; De Jaeger Xavier; Martins-Silva Cristina; Lima Ricardo D F; Amaral Ernani; Menezes Cristiane; Lima Patricia; Neves Cintia M L; Pires Rita G; Gould Thomas W; Welch Ian; Kushmerick Christopher; Guatimosim Cristina; Izquierdo Ivan; Cammarota Martin; Rylett R Jane; Gomez Marcus V; Caron Marc G; Oppenheim Ronald W; Prado Marco A M; Prado Vania F
The vesicular acetylcholine transporter is required for neuromuscular development and function.
Molecular and cellular biology 2009;29(19):5238-50.
2009: Hristova Ventzislava A; Beasley Steven A; Rylett R Jane; Shaw Gary S
Identification of a novel Zn2+-binding domain in the autosomal recessive juvenile Parkinson-related E3 ligase parkin.
The Journal of biological chemistry 2009;284(22):14978-86.
2009: Tichauer Kenneth M; Wong Daisy Y L; Hadway Jennifer A; Rylett R Jane; Lee Ting-Yim; St Lawrence Keith
Assessing the severity of perinatal hypoxia-ischemia in piglets using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen.
Pediatric research 2009;65(3):301-6.
2008: Pinthong Metta; Black Stefanie A G; Ribeiro Fabiola M; Pholpramool Chumpol; Ferguson Stephen S G; Rylett R Jane
Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite.
Molecular pharmacology 2008;73(3):801-12.
2007: Ribeiro Fabiola M; Pinthong Metta; Black Stefanie A G; Gordon Alexis C; Prado Vania F; Prado Marco A M; Rylett R Jane; Ferguson Stephen S G
Regulated recycling and plasma membrane recruitment of the high-affinity choline transporter.
The European journal of neuroscience 2007;26(12):3437-48.
2007: Gill Sandeep K; Ishak Margaret; Dobransky Tomas; Haroutunian Vahram; Davis Kenneth L; Rylett R Jane
82-kDa choline acetyltransferase is in nuclei of cholinergic neurons in human CNS and altered in aging and Alzheimer disease.
Neurobiology of aging 2007;28(7):1028-40.
2006: Kim Ae-Ri; Rylett R Jane; Shilton Brian H
Substrate binding and catalytic mechanism of human choline acetyltransferase.
Biochemistry 2006;45(49):14621-31.
2006: Ribeiro Fabiola M; Black Stefanie A G; Prado Vania F; Rylett R Jane; Ferguson Stephen S G; Prado Marco A M
The "ins" and "outs" of the high-affinity choline transporter CHT1.
Journal of neurochemistry 2006;97(1):1-12.
2005: Gill Sandeep K; Ishak Margaret; Rylett R Jane
Exposure of nuclear antigens in formalin-fixed, paraffin-embedded necropsy human spinal cord tissue: detection of NeuN.
Journal of neuroscience methods 2005;148(1):26-35.
2005: Dobransky Tomas; Rylett R Jane
A model for dynamic regulation of choline acetyltransferase by phosphorylation.
Journal of neurochemistry 2005;95(2):305-13.
2005: Kim Ae-Ri; Dobransky Tomas; Rylett R Jane; Shilton Brian H
Surface-entropy reduction used in the crystallization of human choline acetyltransferase.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 9):1306-10.
2005: Ribeiro Fabiola M; Black Stefanie A G; Cregan Sean P; Prado Vania F; Prado Marco A M; Rylett R Jane; Ferguson Stephen S G
Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif.
Journal of neurochemistry 2005;94(1):86-96.
2005: Kim Ae-Ri; Doherty-Kirby Amanda; Lajoie Gilles; Rylett R Jane; Shilton Brian H
Two methods for large-scale purification of recombinant human choline acetyltransferase.
Protein expression and purification 2005;40(1):107-17.
2004: Dobransky Tomas; Doherty-Kirby Amanda; Kim Ae-Ri; Brewer Dyanne; Lajoie Gilles; Rylett Rebecca J
Protein kinase C isoforms differentially phosphorylate human choline acetyltransferase regulating its catalytic activity.
The Journal of biological chemistry 2004;279(50):52059-68.
2003: Kalisch Bettina E; Demeris C Shaun; Ishak Margaret; Rylett R Jane
Modulation of nerve growth factor-induced activation of MAP kinase in PC12 cells by inhibitors of nitric oxide synthase.
Journal of neurochemistry 2003;87(6):1321-32.
2003: Ribeiro F M; Alves-Silva J; Volknandt W; Martins-Silva C; Mahmud H; Wilhelm A; Gomez M V; Rylett R J; Ferguson S S G; Prado V F; Prado M A M
The hemicholinium-3 sensitive high affinity choline transporter is internalized by clathrin-mediated endocytosis and is present in endosomes and synaptic vesicles.
Journal of neurochemistry 2003;87(1):136-46.
2003: Gill Sandeep K; Bhattacharya Moshmi; Ferguson Stephen S G; Rylett R Jane
Identification of a novel nuclear localization signal common to 69- and 82-kDa human choline acetyltransferase.
The Journal of biological chemistry 2003;278(22):20217-24.
2003: Dobransky Tomas; Rylett R Jane
Functional regulation of choline acetyltransferase by phosphorylation.
Neurochemical research 2003;28(3-4):537-42.
2003: Dobransky Tomas; Brewer Dyanne; Lajoie Gilles; Rylett R Jane
Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42.
The Journal of biological chemistry 2003;278(8):5883-93.
2002: Bhattacharya Moshmi; Anborgh Pieter H; Babwah Andy V; Dale Lianne B; Dobransky Tomas; Benovic Jeffery L; Feldman Ross D; Verdi Joseph M; Rylett R Jane; Ferguson Stephen S G
Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization.
Nature cell biology 2002;4(8):547-55.
2002: Kalisch Bettina E; Bock Nicholas A; Davis Wanda L; Rylett R Jane
Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline acetyltransferase expression in PC12 cells.
Journal of neurochemistry 2002;81(3):624-35.
2002: Baskey Jacqueline C; Kalisch Bettina E; Davis Wanda L; Meakin Susan O; Rylett R Jane
PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.
Journal of neurochemistry 2002;80(3):501-11.
2001: Dobransky T; Davis W L; Rylett R J
Functional characterization of phosphorylation of 69-kDa human choline acetyltransferase at serine 440 by protein kinase C.
The Journal of biological chemistry 2001;276(25):22244-50.
2000: Krol K M; Crutcher K A; Kalisch B E; Rylett R J; Kawaja M D
Absence of p75(NTR) expression reduces nerve growth factor immunolocalization in cholinergic septal neurons.
The Journal of comparative neurology 2000;427(1):54-66.
2000: Dobransky T; Davis W L; Xiao G H; Rylett R J
Expression, purification and characterization of recombinant human choline acetyltransferase: phosphorylation of the enzyme regulates catalytic activity.
The Biochemical journal 2000;349(Pt 1):141-51.
1999: Resendes M C; Dobransky T; Ferguson S S; Rylett R J
Nuclear localization of the 82-kDa form of human choline acetyltransferase.
The Journal of biological chemistry 1999;274(27):19417-21.
1998: Pongrac J L; Rylett R J
NGF-induction of the expression of ChAT mRNA in PC12 cells and primary cultures of embryonic rat basal forebrain.
Brain research. Molecular brain research 1998;62(1):25-34.
1998: Pongrac J L; Rylett R J
Optimization of serum-free culture conditions for growth of embryonic rat cholinergic basal forebrain neurons.
Journal of neuroscience methods 1998;84(1-2):69-76.
1998: Pongrac J L; Rylett R J
Molecular mechanisms regulating NGF-mediated enhancement of cholinergic neuronal phenotype: c-fos trans-activation of the choline acetyltransferase gene.
Journal of molecular neuroscience : MN 1998;11(1):79-93.
1997: Knipper M; Rylett R J
A new twist in an old story: the role for crosstalk of neuronal and trophic activity.
Neurochemistry international 1997;31(5):659-76.
1997: Bartha R; Williamson P C; Drost D J; Malla A; Carr T J; Cortese L; Canaran G; Rylett R J; Neufeld R W
Measurement of glutamate and glutamine in the medial prefrontal cortex of never-treated schizophrenic patients and healthy controls by proton magnetic resonance spectroscopy.
Archives of general psychiatry 1997;54(10):959-65.
1997: Cooke L J; Rylett R J
Inhibitors of serine/threonine phosphatases increase membrane-bound choline acetyltransferase activity and enhance acetylcholine synthesis.
Brain research 1997;751(2):232-8.
1996: Pongrac J L; Rylett R J
Differential effects of nerve growth factor on expression of choline acetyltransferase and sodium-coupled choline transport in basal forebrain cholinergic neurons in culture.
Journal of neurochemistry 1996;66(2):804-10.
1996: Rylett R J; Walters S A; Davis W
Identification and partial characterization of the high-affinity choline carrier from rat brain striatum.
Brain research. Molecular brain research 1996;35(1-2):354-8.
1996: Stanley J A; Williamson P C; Drost D J; Rylett R J; Carr T J; Malla A; Thompson R T
An in vivo proton magnetic resonance spectroscopy study of schizophrenia patients.
Schizophrenia bulletin 1996;22(4):597-609.
1995: Stanley J A; Williamson P C; Drost D J; Carr T J; Rylett R J; Malla A; Thompson R T
An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy.
Archives of general psychiatry 1995;52(5):399-406.
1995: Lawrance G; Rylett R J; Richardson P M; Dunn R J; Dow K E; Riopelle R J
Differentiation effects of ciliary neurotrophic factor on human neuroblastoma cells.
Journal of neurochemistry 1995;64(4):1483-90.
1994: Knipper M; Leung L S; Zhao D; Rylett R J
Short-term modulation of glutamatergic synapses in adult rat hippocampus by NGF.
Neuroreport 1994;5(18):2433-6.
1994: Rylett R J; Williams L R
Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS.
Trends in neurosciences 1994;17(11):486-90.
1994: Ferguson S S; Rylett R J; Collier B
Regulation of rat brain synaptosomal [3H]hemicholinium-3 binding and [3H]choline transport sites following exposure to choline mustard aziridinium ion.
Journal of neurochemistry 1994;63(4):1328-37.
1994: Stanley J A; Williamson P C; Drost D J; Carr T J; Rylett R J; Morrison-Stewart S; Thompson R T
Membrane phospholipid metabolism and schizophrenia: an in vivo 31P-MR spectroscopy study.
Schizophrenia research 1994;13(3):209-15.
1994: Jones K W; Rylett R J; Hammond J R
Effect of cellular differentiation on nucleoside transport in human neuroblastoma cells.
Brain research 1994;660(1):104-12.
1993: Schmidt B M; Rylett R J
Phosphorylation of rat brain choline acetyltransferase and its relationship to enzyme activity.
Journal of neurochemistry 1993;61(5):1774-81.
1993: Rylett R J; Goddard S; Lambros A
Regulation of expression of cholinergic neuronal phenotypic markers in neuroblastoma LA-N-2.
Journal of neurochemistry 1993;61(4):1388-97.
1993: Rylett R J; Davis W; Walters S A
Modulation of high-affinity choline carrier activity following incubation of rat hippocampal synaptosomes with hemicholinium-3.
Brain research 1993;626(1-2):184-9.
1993: Rylett R J; Goddard S; Schmidt B M; Williams L R
Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(9):3956-63.
1993: Schmidt B M; Rylett R J
Basal synthesis of acetylcholine in hippocampal synaptosomes is not dependent upon membrane-bound choline acetyltransferase activity.
Neuroscience 1993;54(3):649-56.
1993: Dunbar G L; Rylett R J; Schmidt B M; Sinclair R C; Williams L R
Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats.
Brain research 1993;604(1-2):266-72.
1993: Williams L R; Rylett R J; Ingram D K; Joseph J A; Moises H C; Tang A H; Mervis R F
Nerve growth factor affects the cholinergic neurochemistry and behavior of aged rats.
Progress in brain research 1993;98():251-6.
1993: Rylett R J; Schmidt B M
Regulation of the synthesis of acetylcholine.
Progress in brain research 1993;98():161-6.
1991: Williams L R; Rylett R J; Moises H C; Tang A H
Exogenous NGF affects cholinergic transmitter function and Y-maze behavior in aged Fischer 344 male rats.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1991;18(3 Suppl):403-7.
1990: Williams L R; Rylett R J
Exogenous nerve growth factor increases the activity of high-affinity choline uptake and choline acetyltransferase in brain of Fisher 344 male rats.
Journal of neurochemistry 1990;55(3):1042-9.
1990: Baskey J C; Colhoun E H; Rylett R J
Cholinergic but not GABAergic neuronal markers are decreased in primary neuronal cultures treated with choline mustard.
Brain research 1990;519(1-2):209-16.
1990: Rylett R J; Walters S A
Uptake and metabolism of [3H]choline mustard by cholinergic nerve terminals from rat brain.
Neuroscience 1990;36(2):483-9.
1990: Rylett R J
Solubilization and partial characterization of [3H]choline mustard-labeled high-affinity choline carrier from presynaptic plasma membrane of Torpedo electric organ.
Journal of molecular neuroscience : MN 1990;2(2):85-90.
1989: Rylett R J
Synaptosomal "membrane-bound" choline acetyltransferase is most sensitive to inhibition by choline mustard.
Journal of neurochemistry 1989;52(3):869-75.
1988: Rylett R J
Affinity labelling and identification of the high-affinity choline carrier from synaptic membranes of Torpedo electromotor nerve terminals with [3H]choline mustard.
Journal of neurochemistry 1988;51(6):1942-5.
1986: Colhoun E H; Myles L A; Rylett R J
An attempt to produce cholinergic hypofunction in rat brain using choline mustard aziridinium ion: neurochemical and histological parameters.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1986;13(4 Suppl):517-20.
1986: Rylett R J
Choline mustard: an irreversible ligand for use in studies of choline transport mechanisms at the cholinergic nerve terminal.
Canadian journal of physiology and pharmacology 1986;64(3):334-40.
1985: Rylett R J; Colhoun E H
Studies on the alkylation of choline acetyltransferase by choline mustard aziridinium ion.
Journal of neurochemistry 1985;44(6):1951-4.
1985: Merskey H; Blume W T; Colhoun E H; Fisman M; Fox A J; Fox H; Hachinski V C; Kral V A; Rylett R J; Smith R
Correlative studies in Alzheimer's disease.
Progress in neuro-psychopharmacology & biological psychiatry 1985;9(5-6):509-14.
1984: Rylett R J; Colhoun E H
An evaluation of irreversible inhibition of synaptosomal high-affinity choline transport by choline mustard aziridinium ion.
Journal of neurochemistry 1984;43(3):787-94.
1984: Rang H P; Rylett R J
The interaction between hexamethonium and tubocurarine on the rat neuromuscular junction.
British journal of pharmacology 1984;81(3):519-31.
1983: Rylett R J; Ball M J; Colhoun E H
Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease.
Brain research 1983;289(1-2):169-75.

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