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Stephen L. Sturley
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10
Oelkers, Peter
8
Deckelbaum, Richard
8
Attie, Alan
6
Billheimer, Jeffrey
6
Cromley, Debra
5
Bard, Martin
4
Ginsberg, Henry
4
Padamsee, Mahajabeen
4
Tinkelenberg, Arthur
4
Wilcox, Lisa
3
Turkish, Aaron
3
Yang, Hong
3
Liscum, Laura
3
Liu, Ying
3
Balderes, Dina
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Geonetwork of Stephen L. Sturley (preview)
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All Publications
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2009: Garbarino Jeanne; Padamsee Mahajabeen; Wilcox Lisa; Oelkers Peter M; D'Ambrosio Diana; Ruggles Kelly V; Ramsey Nicole; Jabado Omar; Turkish Aaron; Sturley Stephen L
Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death.
The Journal of biological chemistry 2009;284(45):30994-1005.
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2009: Munkacsi Andrew B; Pentchev Peter G; Sturley Stephen L
Spreading the wealth: Niemann-Pick type C proteins bind and transport cholesterol.
Cell metabolism 2009;10(1):3-4.
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2009: Turkish Aaron R; Sturley Stephen L
The genetics of neutral lipid biosynthesis: an evolutionary perspective.
American journal of physiology. Endocrinology and metabolism 2009;297(1):E19-27.
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2009: Garbarino Jeanne; Sturley Stephen L
Saturated with fat: new perspectives on lipotoxicity.
Current opinion in clinical nutrition and metabolic care 2009;12(2):110-6.
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2009: Sturley Stephen L; Patterson Marc C; Pentchev Peter
Unraveling the sterol-trafficking defect in Niemann-Pick C disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2093-4.
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2007: Turkish Aaron; Sturley Stephen L
Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT".
American journal of physiology. Gastrointestinal and liver physiology 2007;292(4):G953-7.
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2006: Valachovic Martin; Bareither Bart M; Shah Alam Bhuiyan M; Eckstein James; Barbuch Robert; Balderes Dina; Wilcox Lisa; Sturley Stephen L; Dickson Robert C; Bard Martin
Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles.
Genetics 2006;173(4):1893-908.
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2005: Garbarino J; Sturley S L
Homoeostatic systems for sterols and other lipids.
Biochemical Society transactions 2005;33(Pt 5):1182-5.
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2005: Henneberry Annette L; Sturley Stephen L
Sterol homeostasis in the budding yeast, Saccharomyces cerevisiae.
Seminars in cell & developmental biology 2005;16(2):155-61.
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2005: Turkish Aaron R; Henneberry Annette L; Cromley Debra; Padamsee Mahajabeen; Oelkers Peter; Bazzi Hisham; Christiano Angela M; Billheimer Jeffrey T; Sturley Stephen L
Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily.
The Journal of biological chemistry 2005;280(15):14755-64.
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2005: Rong James X; Kusunoki Jun; Oelkers Peter; Sturley Stephen L; Fisher Edward A
Acyl-coenzymeA (CoA):cholesterol acyltransferase inhibition in rat and human aortic smooth muscle cells is nontoxic and retards foam cell formation.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(1):122-7.
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2004: Sturley Stephen L; Patterson Marc C; Balch William; Liscum Laura
The pathophysiology and mechanisms of NP-C disease.
Biochimica et biophysica acta 2004;1685(1-3):83-7.
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2004: Higaki Katsumi; Almanzar-Paramio Dorca; Sturley Stephen L
Metazoan and microbial models of Niemann-Pick Type C disease.
Biochimica et biophysica acta 2004;1685(1-3):38-47.
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2004: Liscum Laura; Sturley Stephen L
Intracellular trafficking of Niemann-Pick C proteins 1 and 2: obligate components of subcellular lipid transport.
Biochimica et biophysica acta 2004;1685(1-3):22-7.
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2004: Liang John J; Oelkers Peter; Guo Cuiying; Chu Pi-Chun; Dixon Joseph L; Ginsberg Henry N; Sturley Stephen L
Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.
The Journal of biological chemistry 2004;279(43):44938-44.
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2004: Valachovic Martin; Wilcox Lisa I; Sturley Stephen L; Bard Martin
A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism.
Lipids 2004;39(8):747-52.
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2004: Malathi Krishnamurthy; Higaki Katsumi; Tinkelenberg Arthur H; Balderes Dina A; Almanzar-Paramio Dorca; Wilcox Lisa J; Erdeniz Naz; Redican Francis; Padamsee Mahajabeen; Liu Ying; Khan Sohail; Alcantara Frederick; Carstea Eugene D; Morris Jill A; Sturley Stephen L
Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution.
The Journal of cell biology 2004;164(4):547-56.
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2004: Liu Ying; Sturley Stephen L
Nutritional genomics in yeast models.
Nutrition (Burbank, Los Angeles County, Calif.) 2004;20(1):166-72.
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2002: Yu Yi-Hao; Zhang Yiying; Oelkers Peter; Sturley Stephen L; Rader Daniel J; Ginsberg Henry N
Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes.
The Journal of biological chemistry 2002;277(52):50876-84.
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2002: Liscum Laura; Arnio Emily; Anthony Monique; Howley Andrea; Sturley Stephen L; Agler Michele
Identification of a pharmaceutical compound that partially corrects the Niemann-Pick C phenotype in cultured cells.
Journal of lipid research 2002;43(10):1708-17.
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2002: Swain Evelyn; Stukey Joseph; McDonough Virginia; Germann Melody; Liu Ying; Sturley Stephen L; Nickels Joseph T
Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1.
The Journal of biological chemistry 2002;277(39):36152-60.
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2002: Wilcox Lisa J; Balderes Dina A; Wharton Brook; Tinkelenberg Arthur H; Rao Govinda; Sturley Stephen L
Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.
The Journal of biological chemistry 2002;277(36):32466-72.
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2002: Oelkers Peter; Cromley Debra; Padamsee Mahajabeen; Billheimer Jeffrey T; Sturley Stephen L
The DGA1 gene determines a second triglyceride synthetic pathway in yeast.
The Journal of biological chemistry 2002;277(11):8877-81.
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2001: Liang J S; Distler O; Cooper D A; Jamil H; Deckelbaum R J; Ginsberg H N; Sturley S L
HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia.
Nature medicine 2001;7(12):1327-31.
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2001: Jensen-Pergakes K; Guo Z; Giattina M; Sturley S L; Bard M
Transcriptional regulation of the two sterol esterification genes in the yeast Saccharomyces cerevisiae.
Journal of bacteriology 2001;183(17):4950-7.
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2001: Guo Z; Cromley D; Billheimer J T; Sturley S L
Identification of potential substrate-binding sites in yeast and human acyl-CoA sterol acyltransferases by mutagenesis of conserved sequences.
Journal of lipid research 2001;42(8):1282-91.
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2001: Seo T; Oelkers P M; Giattina M R; Worgall T S; Sturley S L; Deckelbaum R J
Differential modulation of ACAT1 and ACAT2 transcription and activity by long chain free fatty acids in cultured cells.
Biochemistry 2001;40(15):4756-62.
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2001: Distler O; Cooper D A; Deckelbaum R J; Sturley S L
Hyperlipidemia and inhibitors of HIV protease.
Current opinion in clinical nutrition and metabolic care 2001;4(2):99-103.
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2000: Sturley S L
Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast.
Biochimica et biophysica acta 2000;1529(1-3):155-63.
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2000: Tinkelenberg A H; Liu Y; Alcantara F; Khan S; Guo Z; Bard M; Sturley S L
Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1.
The Journal of biological chemistry 2000;275(52):40667-70.
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2000: Oelkers P; Tinkelenberg A; Erdeniz N; Cromley D; Billheimer J T; Sturley S L
A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast.
The Journal of biological chemistry 2000;275(21):15609-12.
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2000: Ho Y Y; Al-Haideri M; Mazzone T; Vogel T; Presley J F; Sturley S L; Deckelbaum R J
Endogenously expressed apolipoprotein E has different effects on cell lipid metabolism as compared to exogenous apolipoprotein E carried on triglyceride-rich particles.
Biochemistry 2000;39(16):4746-54.
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2000: Bouvier-Navé P; Benveniste P; Oelkers P; Sturley S L; Schaller H
Expression in yeast and tobacco of plant cDNAs encoding acyl CoA:diacylglycerol acyltransferase.
European journal of biochemistry / FEBS 2000;267(1):85-96.
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1999: Ahmed A; Sesti F; Ilan N; Shih T M; Sturley S L; Goldstein S A
A molecular target for viral killer toxin: TOK1 potassium channels.
Cell 1999;99(3):283-91.
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1998: Liang J; Wu X; Jiang H; Zhou M; Yang H; Angkeow P; Huang L S; Sturley S L; Ginsberg H
Translocation efficiency, susceptibility to proteasomal degradation, and lipid responsiveness of apolipoprotein B are determined by the presence of beta sheet domains.
The Journal of biological chemistry 1998;273(52):35216-21.
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1998: Oelkers P; Behari A; Cromley D; Billheimer J T; Sturley S L
Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes.
The Journal of biological chemistry 1998;273(41):26765-71.
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1998: Worgall T S; Sturley S L; Seo T; Osborne T F; Deckelbaum R J
Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein.
The Journal of biological chemistry 1998;273(40):25537-40.
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1998: Sturley S L
A molecular approach to understanding human sterol metabolism using yeast genetics.
Current opinion in lipidology 1998;9(2):85-91.
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1997: Al-Haideri M; Goldberg I J; Galeano N F; Gleeson A; Vogel T; Gorecki M; Sturley S L; Deckelbaum R J
Heparan sulfate proteoglycan-mediated uptake of apolipoprotein E-triglyceride-rich lipoprotein particles: a major pathway at physiological particle concentrations.
Biochemistry 1997;36(42):12766-72.
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1997: Gupta G; Kim J; Yang L; Sturley S L; Danziger R S
Expression and purification of soluble, active heterodimeric guanylyl cyclase from baculovirus.
Protein expression and purification 1997;10(3):325-30.
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1997: Carstea E D; Morris J A; Coleman K G; Loftus S K; Zhang D; Cummings C; Gu J; Rosenfeld M A; Pavan W J; Krizman D B; Nagle J; Polymeropoulos M H; Sturley S L; Ioannou Y A; Higgins M E; Comly M; Cooney A; Brown A; Kaneski C R; Blanchette-Mackie E J; Dwyer N K; Neufeld E B; Chang T Y; Liscum L; Strauss J F; Ohno K; Zeigler M; Carmi R; Sokol J; Markie D; O'Neill R R; van Diggelen O P; Elleder M; Patterson M C; Brady R O; Vanier M T; Pentchev P G; Tagle D A
Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.
Science (New York, N.Y.) 1997;277(5323):228-31.
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1997: Sturley S L
Molecular aspects of intracellular sterol esterification: the acyl coenzyme A: cholesterol acyltransferase reaction.
Current opinion in lipidology 1997;8(3):167-73.
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1997: Laboissière M C; Sturley S L; Raines R T
Protein disulfide isomerase in spore germination and cell division.
Biological chemistry 1997;378(5):431-7.
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1997: Yang H; Cromley D; Wang H; Billheimer J T; Sturley S L
Functional expression of a cDNA to human acyl-coenzyme A:cholesterol acyltransferase in yeast. Species-dependent substrate specificity and inhibitor sensitivity.
The Journal of biological chemistry 1997;272(7):3980-5.
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1996: Dirlam K A; Gretch D G; LaCount D J; Sturley S L; Attie A D
Expression and characterization of a truncated, soluble, low-density lipoprotein receptor.
Protein expression and purification 1996;8(4):489-500.
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1996: Arthington-Skaggs B A; Crowell D N; Yang H; Sturley S L; Bard M
Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway.
FEBS letters 1996;392(2):161-5.
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1996: Yang H; Bard M; Bruner D A; Gleeson A; Deckelbaum R J; Aljinovic G; Pohl T M; Rothstein R; Sturley S L
Sterol esterification in yeast: a two-gene process.
Science (New York, N.Y.) 1996;272(5266):1353-6.
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1996: Gretch D G; Sturley S L; Wang L; Lipton B A; Dunning A; Grunwald K A; Wetterau J R; Yao Z; Talmud P; Attie A D
The amino terminus of apolipoprotein B is necessary but not sufficient for microsomal triglyceride transfer protein responsiveness.
The Journal of biological chemistry 1996;271(15):8682-91.
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1995: Laboissiere M C; Sturley S L; Raines R T
The essential function of protein-disulfide isomerase is to unscramble non-native disulfide bonds.
The Journal of biological chemistry 1995;270(47):28006-9.
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1995: Choi S Y; Sivaram P; Walker D E; Curtiss L K; Gretch D G; Sturley S L; Attie A D; Deckelbaum R J; Goldberg I J
Lipoprotein lipase association with lipoproteins involves protein-protein interaction with apolipoprotein B.
The Journal of biological chemistry 1995;270(14):8081-6.
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1995: Gretch D G; Sturley S L; Attie A D
Human apolipoprotein E mediates processive buoyant lipoprotein formation in insect larvae.
Biochemistry 1995;34(2):545-52.
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1994: Sturley S L; Talmud P J; Brasseur R; Culbertson M R; Humphries S E; Attie A D
Human apolipoprotein B signal sequence variants confer a secretion-defective phenotype when expressed in yeast.
The Journal of biological chemistry 1994;269(34):21670-5.
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1993: Purtell C; Maeda N; Ebert D L; Kaiser M; Lund-Katz S; Sturley S L; Kodoyianni V; Grunwald K; Nevin D N; Aiello R J
Nucleotide sequence encoding the carboxyl-terminal half of apolipoprotein B from spontaneously hypercholesterolemic pigs.
Journal of lipid research 1993;34(8):1323-35.
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1993: Kaiser M E; Nevin D N; Sturley S L; Purtell C; Attie A D
Determination of pig apolipoprotein B genotype by gene amplification and restriction fragment length polymorphism analysis.
Animal genetics 1993;24(2):117-20.
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1991: Gretch D G; Sturley S L; Friesen P D; Beckage N E; Attie A D
Baculovirus-mediated expression of human apolipoprotein E in Manduca sexta larvae generates particles that bind to the low density lipoprotein receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8530-3.
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1991: Sturley S L; Culbertson M R; Attie A D
Secretion and lipid association of human apolipoprotein E in Saccharomyces cerevisiae requires a host mutation in sterol esterification and uptake.
The Journal of biological chemistry 1991;266(25):16273-6.
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1991: Mark H F; el-Sherbeini M; Goldberg M; Suri P K; Sturley S L; Bostian K A; Knopf P M
Schistosoma mansoni: two-dimensional gel electrophoretic analysis of antigens uniquely immunoreactive with protective rat serum.
Experimental parasitology 1991;72(3):294-305.
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1988: Douglas C M; Sturley S L; Bostian K A
Role of protein processing, intracellular trafficking and endocytosis in production of and immunity to yeast killer toxin.
European journal of epidemiology 1988;4(4):400-8.
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1986: Sturley S L; Elliot Q; LeVitre J; Tipper D J; Bostian K A
Mapping of functional domains within the Saccharomyces cerevisiae type 1 killer preprotoxin.
The EMBO journal 1986;5(12):3381-9.
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1986: Hanes S D; Burn V E; Sturley S L; Tipper D J; Bostian K A
Expression of a cDNA derived from the yeast killer preprotoxin gene: implications for processing and immunity.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1675-9.
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