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Mark A. Smith

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
McShea Andy; Leissle Kristy; Smith Mark A
The essence of chocolate: a rich, dark, and well-kept secret.
Sun Kai-Hui; Lee Hyoung-gon; Smith Mark A; Shah Kavita
Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease.
Dwyer Barney E; Stone Meghan L; Gorman Nadia; Sinclair Peter R; Perry George; Smith Mark A; Zhu Xiongwei
Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease.

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All Publications

2009: McShea Andy; Leissle Kristy; Smith Mark A
The essence of chocolate: a rich, dark, and well-kept secret.
Nutrition (Burbank, Los Angeles County, Calif.) 2009;25(11-12):1104-5.
2009: Sun Kai-Hui; Lee Hyoung-gon; Smith Mark A; Shah Kavita
Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease.
Molecular biology of the cell 2009;20(21):4611-9.
2009: Dwyer Barney E; Stone Meghan L; Gorman Nadia; Sinclair Peter R; Perry George; Smith Mark A; Zhu Xiongwei
Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease.
Neuroscience letters 2009;461(3):302-5.
2009: Dwyer Barney E; Smith Mark A; Richardson Sandy L; Perry George; Zhu Xiongwei
Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease.
Neuroscience letters 2009;460(2):180-4.
2009: Wang Xinglong; Su Bo; Lee Hyoung-gon; Li Xinyi; Perry George; Smith Mark A; Zhu Xiongwei
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(28):9090-103.
2009: Nunomura Akihiko; Hofer Tim; Moreira Paula I; Castellani Rudy J; Smith Mark A; Perry George
RNA oxidation in Alzheimer disease and related neurodegenerative disorders.
Acta neuropathologica 2009;118(1):151-66.
2009: Perez Mar; Santa-Maria Ismael; Gomez de Barreda Elena; Zhu Xiongwei; Cuadros Raquel; Cabrero Jose Roman; Sanchez-Madrid Francisco; Dawson Hana N; Vitek Michael P; Perry George; Smith Mark A; Avila Jesus
Tau--an inhibitor of deacetylase HDAC6 function.
Journal of neurochemistry 2009;109(6):1756-66.
2009: Smith Mark A; Casadesus Gemma
Walking toward a convergence in aging research.
Frontiers in neuroscience 2009;3(1):1.
2009: Barbeito Ana G; Garringer Holly J; Baraibar Martin A; Gao Xiaoying; Arredondo Miguel; Núñez Marco T; Smith Mark A; Ghetti Bernardino; Vidal Ruben
Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene.
Journal of neurochemistry 2009;109(4):1067-78.
2009: Greco Steven J; Sarkar Sraboni; Casadesus Gemma; Zhu Xiongwei; Smith Mark A; Ashford J Wesson; Johnston Jane M; Tezapsidis Nikolaos
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Neuroscience letters 2009;455(3):191-4.
2009: Liu Gang; Men Ping; Kudo Wataru; Perry George; Smith Mark A
Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: a novel therapeutic approach for Alzheimer disease.
Neuroscience letters 2009;455(3):187-90.
2009: Wang Xinglong; Su Bo; Zheng Ling; Perry George; Smith Mark A; Zhu Xiongwei
The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease.
Journal of neurochemistry 2009;109 Suppl 1():153-9.
2009: Obrenovich Mark E; Morales Ludis A; Cobb Celia J; Shenk Justin C; Méndez Gina M; Fischbach Kathryn; Smith Mark A; Qasimov Eldar K; Perry George; Aliev Gjumrakch
Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation.
Journal of cellular and molecular medicine 2009;13(5):853-65.
2009: Dwyer Barney E; Zacharski Leo R; Balestra Dominic J; Lerner Alan J; Perry George; Zhu Xiongwei; Smith Mark A
Getting the iron out: phlebotomy for Alzheimer's disease?
Medical hypotheses 2009;72(5):504-9.
2009: Reddy V Prakash; Zhu Xiongwei; Perry George; Smith Mark A
Oxidative stress in diabetes and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2009;16(4):763-74.
2009: Tezapsidis Nikolaos; Johnston Jane M; Smith Mark A; Ashford J Wesson; Casadesus Gemma; Robakis Nikolaos K; Wolozin Benjamin; Perry George; Zhu Xiongwei; Greco Steven J; Sarkar Sraboni
Leptin: a novel therapeutic strategy for Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2009;16(4):731-40.
2009: Rajendran Reshmi; Minqin Ren; Ynsa Maria Dolores; Casadesus Gemma; Smith Mark A; Perry George; Halliwell Barry; Watt Frank
A novel approach to the identification and quantitative elemental analysis of amyloid deposits--insights into the pathology of Alzheimer's disease.
Biochemical and biophysical research communications 2009;382(1):91-5.
2009: Tajes Marta; Yeste-Velasco Marc; Zhu Xiongwei; Chou Steven P; Smith Mark A; Pallàs Mercè; Camins Antoni; Casadesús Gemma
Activation of Akt by lithium: pro-survival pathways in aging.
Mechanisms of ageing and development 2009;130(4):253-61.
2009: Castellani Rudy J; Zhu Xiongwei; Lee Hyoung-Gon; Smith Mark A; Perry George
Molecular Pathogenesis of Alzheimer's Disease: Reductionist versus Expansionist Approaches.
International journal of molecular sciences 2009;10(3):1386-406.
2009: Yeste-Velasco M; Folch J; Casadesús G; Smith M A; Pallàs M; Camins A
Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry.
Neuroscience 2009;159(3):1135-47.
2009: Tezapsidis Nikolaos; Smith Mark A; Ashford J Wes
Central obesity and increased risk of dementia more than three decades later.
Neurology 2009;72(11):1030-1; author reply 1031.
2009: Lee Hyun-Pil; Zhu Xiaochun; Zhu Xiongwei; Skidmore S Chad; Perry George; Sayre Lawrence M; Smith Mark A; Lee Hyoung-Gon
The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells.
Journal of neurochemistry 2009;108(6):1434-41.
2009: Lee Hyoung-gon; Casadesus Gemma; Nunomura Akihiko; Zhu Xiongwei; Castellani Rudy J; Richardson Sandy L; Perry George; Felsher Dean W; Petersen Robert B; Smith Mark A
The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse.
The American journal of pathology 2009;174(3):891-7.
2009: Pallàs Mercè; Casadesús Gemma; Smith Mark A; Coto-Montes Ana; Pelegri Carme; Vilaplana Jordi; Camins Antoni
Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection.
Current neurovascular research 2009;6(1):70-81.
2009: Perry George; Zhu Xiongwei; Moreira Paula I; Smith Mark A
Altered redox balance in disease: can we change the new equilibria?
Annals of neurology 2009;65(2):121-3.
2009: Guglielmotto Michela; Aragno Manuela; Autelli Riccardo; Giliberto Luca; Novo Erica; Colombatto Sebastiano; Danni Oliviero; Parola Maurizio; Smith Mark A; Perry George; Tamagno Elena; Tabaton Massimo
The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha.
Journal of neurochemistry 2009;108(4):1045-56.
2009: Siedlak Sandra L; Casadesus Gemma; Webber Kate M; Pappolla Miguel A; Atwood Craig S; Smith Mark A; Perry George
Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.
Free radical research 2009;43(2):156-64.
2009: Lee Hyoung-Gon; Casadesus Gemma; Zhu Xiongwei; Castellani Rudy J; McShea Andrew; Perry George; Petersen Robert B; Bajic Vladan; Smith Mark A
Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease.
Neurochemistry international 2009;54(2):84-8.
2009: Ramiro-Puig Emma; Casadesús Gemma; Lee Hyoung-gon; Zhu Xiongwei; McShea Andrew; Perry George; Pérez-Cano Francisco J; Smith Mark A; Castell Margarida
Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress.
European journal of nutrition 2009;48(1):54-61.
2009: Aliev Gjumrakch; Liu Jiankang; Shenk Justin C; Fischbach Kathryn; Pacheco Gerardo J; Chen Shu G; Obrenovich Mark E; Ward Walter F; Richardson Arlan G; Smith Mark A; Gasimov Eldar; Perry George; Ames Bruce N
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.
Journal of cellular and molecular medicine 2009;13(2):320-33.
2009: Lee Hyoung-gon; Zhu Xiongwei; Casadesus Gemma; Pallàs Mercé; Camins Antoni; O'Neill Michael J; Nakanishi Shigetada; Perry George; Smith Mark A
The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
Brain research 2009;1249():244-50.
2009: Cardoso Susana; Correia Sónia; Santos Renato X; Carvalho Cristina; Santos Maria S; Oliveira Catarina R; Perry George; Smith Mark A; Zhu Xiongwei; Moreira Paula I
Insulin is a Two-Edged Knife on the Brain.
Journal of Alzheimer's disease : JAD 2009;18(3):483-507.
2009: Lee Hyoung-gon; Chen Qun; Wolfram Julie A; Richardson Sandy L; Liner Anna; Siedlak Sandra L; Zhu Xiongwei; Ziats Nicholas P; Fujioka Hisashi; Felsher Dean W; Castellani Rudy J; Valencik Maria L; McDonald John A; Hoit Brian D; Lesnefsky Edward J; Smith Mark A
Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure.
PloS one 2009;4(9):e7172.
2009: Su Bo; Liu Haihua; Wang Xinglong; Chen Shu G; Siedlak Sandra L; Kondo Eisaku; Choi Raymond; Takeda Atsushi; Castellani Rudy J; Perry George; Smith Mark A; Zhu Xiongwei; Lee Hyoung-Gon
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease.
Molecular neurodegeneration 2009;4():32.
2009: Castellani Rudy J; Lee Hyoung-gon; Siedlak Sandra L; Nunomura Akihiko; Hayashi Takaaki; Nakamura Masao; Zhu Xiongwei; Perry George; Smith Mark A
Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta.
Journal of Alzheimer's disease : JAD 2009;18(2):447-52.
2009: Stone Jeremy G; Rolston Raj K; Ueda Masumi; Lee Hyoung-Gon; Richardson Sandy L; Castellani Rudy J; Perry George; Smith Mark A
Evidence for the Novel Expression of Human Kallikrein-related Peptidase 3, Prostate-Specific Antigen, in the Brain.
International journal of clinical and experimental pathology 2009;2(3):267-74.
2008: Myung Na-Hye; Zhu Xiongwei; Kruman Inna I; Castellani Rudy J; Petersen Robert B; Siedlak Sandra L; Perry George; Smith Mark A; Lee Hyoung-Gon
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.
Age (Dordrecht, Netherlands) 2008;30(4):209-15.
2008: Pallas Merce; Camins Antoni; Smith Mark A; Perry George; Lee Hyoung-gon; Casadesus Gemma
From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).
Journal of Alzheimer's disease : JAD 2008;15(4):615-24.
2008: Su B; Wang X; Nunomura A; Moreira P I; Lee H-gon; Perry G; Smith M A; Zhu X
Oxidative stress signaling in Alzheimer's disease.
Current Alzheimer research 2008;5(6):525-32.
2008: McShea Andrew; Ramiro-Puig Emma; Munro Sandra B; Casadesus Gemma; Castell Margarida; Smith Mark A
Clinical benefit and preservation of flavonols in dark chocolate manufacturing.
Nutrition reviews 2008;66(11):630-41.
2008: Aliev Gjumrakch; Obrenovich Mark E; Reddy V Prakash; Shenk Justin C; Moreira Paula I; Nunomura Akihiko; Zhu Xiongwei; Smith Mark A; Perry George
Antioxidant therapy in Alzheimer's disease: theory and practice.
Mini reviews in medicinal chemistry 2008;8(13):1395-406.
2008: Greco Steven J; Sarkar Sraboni; Johnston Jane M; Zhu Xiongwei; Su Bo; Casadesus Gemma; Ashford J Wesson; Smith Mark A; Tezapsidis Nikolaos
Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells.
Biochemical and biophysical research communications 2008;376(3):536-41.
2008: Marlatt Michael W; Lucassen Paul J; Perry George; Smith Mark A; Zhu Xiongwei
Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies.
Journal of Alzheimer's disease : JAD 2008;15(2):199-210.
2008: Gonzalez-Cuyar Luis F; Perry George; Miyajima Hiroaki; Atwood Craig S; Riveros-Angel Marcela; Lyons Patrick F; Siedlak Sandra L; Smith Mark A; Castellani Rudy J
Redox active iron accumulation in aceruloplasminemia.
Neuropathology : official journal of the Japanese Society of Neuropathology 2008;28(5):466-71.
2008: Spremo-Potparevic Biljana; Zivkovic Lada; Djelic Ninoslav; Plecas-Solarovic Bosiljka; Smith Mark A; Bajic Vladan
Premature centromere division of the X chromosome in neurons in Alzheimer's disease.
Journal of neurochemistry 2008;106(5):2218-23.
2008: Castellani Rudy J; Nunomura Akihiko; Lee Hyoung-gon; Perry George; Smith Mark A
Phosphorylated tau: toxic, protective, or none of the above.
Journal of Alzheimer's disease : JAD 2008;14(4):377-83.
2008: Friedland Robert P; Tedesco Johnathan M; Wilson Andrea C; Atwood Craig S; Smith Mark A; Perry George; Zagorski Michael G
Antibodies to potato virus Y bind the amyloid beta peptide: immunohistochemical and NMR studies.
The Journal of biological chemistry 2008;283(33):22550-6.
2008: Gustaw Katarzyna A; Garrett Matthew R; Lee Hyoung-Gon; Castellani Rudy J; Zagorski Michael G; Prakasam Annamalai; Siedlak Sandra L; Zhu Xiongwei; Perry George; Petersen Robert B; Friedland Robert P; Smith Mark A
Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis.
Journal of neurochemistry 2008;106(3):1350-6.
2008: Zhu X; Siedlak S L; Wang Y; Perry G; Castellani R J; Cohen M L; Smith M A
Neuronal binucleation in Alzheimer disease hippocampus.
Neuropathology and applied neurobiology 2008;34(4):457-65.
2008: Collingwood Joanna F; Chong Ryan K K; Kasama Takeshi; Cervera-Gontard Lionel; Dunin-Borkowski Rafal E; Perry George; Pósfai Mihály; Siedlak Sandra L; Simpson Edward T; Smith Mark A; Dobson Jon
Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material.
Journal of Alzheimer's disease : JAD 2008;14(2):235-45.
2008: Tajes Marta; Gutierrez-Cuesta Javier; Folch Jaume; Ferrer Isidre; Caballero Beatriz; Smith Mark A; Casadesus Gemma; Camins Antoni; Pallás Mercé
Lithium treatment decreases activities of tau kinases in a murine model of senescence.
Journal of neuropathology and experimental neurology 2008;67(6):612-23.
2008: Castellani Rudy J; Lee Hyoung-Gon; Zhu Xiongwei; Perry George; Smith Mark A
Alzheimer disease pathology as a host response.
Journal of neuropathology and experimental neurology 2008;67(6):523-31.
2008: Castellani Rudy J; Nunomura Akihiko; Rolston Raj K; Moreira Paula I; Takeda Atsushi; Perry George; Smith Mark A
Sublethal RNA oxidation as a mechanism for neurodegenerative disease.
International journal of molecular sciences 2008;9(5):789-806.
2008: Pizarro Javier G; Yeste-Velasco Marc; Rimbau Victor; Casadesús Gemma; Smith Mark A; Pallàs Mercè; Folch Jaume; Camins Antoni
Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2008;26(3-4):269-76.
2008: Shah Reena S; Lee Hyoung-Gon; Xiongwei Zhu; Perry George; Smith Mark A; Castellani Rudy J
Current approaches in the treatment of Alzheimer's disease.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2008;62(4):199-207.
2008: Mondragón-Rodríguez Siddhartha; Basurto-Islas Gustavo; Santa-Maria Ismael; Mena Raúl; Binder Lester I; Avila Jesús; Smith Mark A; Perry George; García-Sierra Francisco
Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease.
International journal of experimental pathology 2008;89(2):81-90.
2008: Moreira Paula I; Nunomura Akihiko; Nakamura Masao; Takeda Atsushi; Shenk Justin C; Aliev Gjumrakch; Smith Mark A; Perry George
Nucleic acid oxidation in Alzheimer disease.
Free radical biology & medicine 2008;44(8):1493-505.
2008: Moreira Paula I; Santos Maria S; Oliveira Catarina R; Shenk Justin C; Nunomura Akihiko; Smith Mark A; Zhu Xiongwei; Perry George
Alzheimer disease and the role of free radicals in the pathogenesis of the disease.
CNS & neurological disorders drug targets 2008;7(1):3-10.
2008: Klionsky Daniel J; Abeliovich Hagai; Agostinis Patrizia; Agrawal Devendra K; Aliev Gjumrakch; Askew David S; Baba Misuzu; Baehrecke Eric H; Bahr Ben A; Ballabio Andrea; Bamber Bruce A; Bassham Diane C; Bergamini Ettore; Bi Xiaoning; Biard-Piechaczyk Martine; Blum Janice S; Bredesen Dale E; Brodsky Jeffrey L; Brumell John H; Brunk Ulf T; Bursch Wilfried; Camougrand Nadine; Cebollero Eduardo; Cecconi Francesco; Chen Yingyu; Chin Lih-Shen; Choi Augustine; Chu Charleen T; Chung Jongkyeong; Clarke Peter G H; Clark Robert S B; Clarke Steven G; Clavé Corinne; Cleveland John L; Codogno Patrice; Colombo María I; Coto-Montes Ana; Cregg James M; Cuervo Ana Maria; Debnath Jayanta; Demarchi Francesca; Dennis Patrick B; Dennis Phillip A; Deretic Vojo; Devenish Rodney J; Di Sano Federica; Dice J Fred; Difiglia Marian; Dinesh-Kumar Savithramma; Distelhorst Clark W; Djavaheri-Mergny Mojgan; Dorsey Frank C; Dröge Wulf; Dron Michel; Dunn William A; Duszenko Michael; Eissa N Tony; Elazar Zvulun; Esclatine Audrey; Eskelinen Eeva-Liisa; Fésüs László; Finley Kim D; Fuentes José M; Fueyo Juan; Fujisaki Kozo; Galliot Brigitte; Gao Fen-Biao; Gewirtz David A; Gibson Spencer B; Gohla Antje; Goldberg Alfred L; Gonzalez Ramon; González-Estévez Cristina; Gorski Sharon; Gottlieb Roberta A; Häussinger Dieter; He You-Wen; Heidenreich Kim; Hill Joseph A; Høyer-Hansen Maria; Hu Xun; Huang Wei-Pang; Iwasaki Akiko; Jäättelä Marja; Jackson William T; Jiang Xuejun; Jin Shengkan; Johansen Terje; Jung Jae U; Kadowaki Motoni; Kang Chanhee; Kelekar Ameeta; Kessel David H; Kiel Jan A K W; Kim Hong Pyo; Kimchi Adi; Kinsella Timothy J; Kiselyov Kirill; Kitamoto Katsuhiko; Knecht Erwin; Komatsu Masaaki; Kominami Eiki; Kondo Seiji; Kovács Attila L; Kroemer Guido; Kuan Chia-Yi; Kumar Rakesh; Kundu Mondira; Landry Jacques; Laporte Marianne; Le Weidong; Lei Huan-Yao; Lenardo Michael J; Levine Beth; Lieberman Andrew; Lim Kah-Leong; Lin Fu-Cheng; Liou Willisa; Liu Leroy F; Lopez-Berestein Gabriel; López-Otín Carlos; Lu Bo; Macleod Kay F; Malorni Walter; Martinet Wim; Matsuoka Ken; Mautner Josef; Meijer Alfred J; Meléndez Alicia; Michels Paul; Miotto Giovanni; Mistiaen Wilhelm P; Mizushima Noboru; Mograbi Baharia; Monastyrska Iryna; Moore Michael N; Moreira Paula I; Moriyasu Yuji; Motyl Tomasz; Münz Christian; Murphy Leon O; Naqvi Naweed I; Neufeld Thomas P; Nishino Ichizo; Nixon Ralph A; Noda Takeshi; Nürnberg Bernd; Ogawa Michinaga; Oleinick Nancy L; Olsen Laura J; Ozpolat Bulent; Paglin Shoshana; Palmer Glen E; Papassideri Issidora; Parkes Miles; Perlmutter David H; Perry George; Piacentini Mauro; Pinkas-Kramarski Ronit; Prescott Mark; Proikas-Cezanne Tassula; Raben Nina; Rami Abdelhaq; Reggiori Fulvio; Rohrer Bärbel; Rubinsztein David C; Ryan Kevin M; Sadoshima Junichi; Sakagami Hiroshi; Sakai Yasuyoshi; Sandri Marco; Sasakawa Chihiro; Sass Miklós; Schneider Claudio; Seglen Per O; Seleverstov Oleksandr; Settleman Jeffrey; Shacka John J; Shapiro Irving M; Sibirny Andrei; Silva-Zacarin Elaine C M; Simon Hans-Uwe; Simone Cristiano; Simonsen Anne; Smith Mark A; Spanel-Borowski Katharina; Srinivas Vickram; Steeves Meredith; Stenmark Harald; Stromhaug Per E; Subauste Carlos S; Sugimoto Seiichiro; Sulzer David; Suzuki Toshihiko; Swanson Michele S; Tabas Ira; Takeshita Fumihiko; Talbot Nicholas J; Tallóczy Zsolt; Tanaka Keiji; Tanaka Kozo; Tanida Isei; Taylor Graham S; Taylor J Paul; Terman Alexei; Tettamanti Gianluca; Thompson Craig B; Thumm Michael; Tolkovsky Aviva M; Tooze Sharon A; Truant Ray; Tumanovska Lesya V; Uchiyama Yasuo; Ueno Takashi; Uzcátegui Néstor L; van der Klei Ida; Vaquero Eva C; Vellai Tibor; Vogel Michael W; Wang Hong-Gang; Webster Paul; Wiley John W; Xi Zhijun; Xiao Gutian; Yahalom Joachim; Yang Jin-Ming; Yap George; Yin Xiao-Ming; Yoshimori Tamotsu; Yu Li; Yue Zhenyu; Yuzaki Michisuke; Zabirnyk Olga; Zheng Xiaoxiang; Zhu Xiongwei; Deter Russell L
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy 2008;4(2):151-75.
2008: Tamagno Elena; Guglielmotto Michela; Aragno Manuela; Borghi Roberta; Autelli Riccardo; Giliberto Luca; Muraca Giuseppe; Danni Oliviero; Zhu Xiongwei; Smith Mark A; Perry George; Jo Dong-Gyu; Mattson Mark P; Tabaton Massimo
Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein.
Journal of neurochemistry 2008;104(3):683-95.
2008: Mondragón-Rodríguez S; Mena R; Binder L I; Smith M A; Perry G; García-Sierra F
Conformational changes and cleavage of tau in Pick bodies parallel the early processing of tau found in Alzheimer pathology.
Neuropathology and applied neurobiology 2008;34(1):62-75.
2008: Sayre Lawrence M; Perry George; Smith Mark A
Oxidative stress and neurotoxicity.
Chemical research in toxicology 2008;21(1):172-88.
2008: Chan Hsien W; Liu Tianbing; Verdile Giuseppe; Bishop Glenda; Haasl Ryan J; Smith Mark A; Perry George; Martins Ralph N; Atwood Craig S
Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity.
International journal of clinical and experimental medicine 2008;1(1):76-88.
2008: Aliev Gjumrakch; Gasimov Eldar; Obrenovich Mark E; Fischbach Kathryn; Shenk Justin C; Smith Mark A; Perry George
Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease.
Vascular health and risk management 2008;4(3):721-30.
2008: Bryan Kathryn J; Zhu Xiongwei; Harris Peggy L; Perry George; Castellani Rudy J; Smith Mark A; Casadesus Gemma
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease.
Molecular neurodegeneration 2008;3():13.
2008: Perry George; Castellani Rudy J; Moreira Paula I; Lee Hyoung-Gon; Zhu Xiongwei; Smith Mark A
Pathology's New Role: Defining Disease Process and Protective Responses.
International journal of clinical and experimental pathology 2008;1(1):1-4.
2008: Thakur Akanksha; Siedlak Sandra L; James Sheronica L; Bonda David J; Rao Akanksha; Webber Kate M; Camins Antoni; Pallàs Mercé; Casadesus Gemma; Lee Hyoung-Gon; Bowser Robert; Raina Arun K; Perry George; Smith Mark A; Zhu Xiongwei
Retinoblastoma Protein Phosphorylation at Multiple Sites is Associated with Neurofibrillary Pathology in Alzheimer Disease.
International journal of clinical and experimental pathology 2008;1(2):134-46.
2008: Gelfand Steven L; Vento Maximo; Sastre Juan; Lust W David; Smith Mark A; Perry George; Walsh Michele; Martin Richard
A new model of oxidative stress in rat pups.
Neonatology 2008;94(4):293-9.
2008: Casadesus Gemma; Rolston Raj K; Webber Kate M; Atwood Craig S; Bowen Richard L; Perry George; Smith Mark A
Menopause, estrogen, and gonadotropins in Alzheimer's disease.
Advances in clinical chemistry 2008;45():139-53.
2008: Perry George; Zhu Xiongwei; Babar Asim K; Siedlak Sandra L; Yang Qiwei; Ito Genta; Iwatsubo Takeshi; Smith Mark A; Chen Shu G
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Neuro-degenerative diseases 2008;5(3-4):222-4.
2007: Webber Kate M; Casadesus Gemma; Bowen Richard L; Perry George; Smith Mark A
Evidence for the role of luteinizing hormone in Alzheimer disease.
Endocrine, metabolic & immune disorders drug targets 2007;7(4):300-3.
2007: Nunomura A; Moreira P I; Lee H G; Zhu X; Castellani R J; Smith M A; Perry G
Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases.
CNS & neurological disorders drug targets 2007;6(6):411-23.
2007: Castellani Rudy J; Perry George; Smith Mark A
The role of novel chitin-like polysaccharides in Alzheimer disease.
Neurotoxicity research 2007;12(4):269-74.
2007: Wang Xinglong; Su Bo; Perry George; Smith Mark A; Zhu Xiongwei
Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease.
Free radical biology & medicine 2007;43(12):1569-73.
2007: Hayashi Takaaki; Shishido Naomi; Nakayama Kenji; Nunomura Akihiko; Smith Mark A; Perry George; Nakamura Masao
Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide.
Free radical biology & medicine 2007;43(11):1552-9.
2007: Nakamura M; Shishido N; Nunomura Akihiko; Smith Mark A; Perry George; Hayashi Y; Nakayama K; Hayashi T
Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron.
Biochemistry 2007;46(44):12737-43.
2007: Moreira Paula I; Siedlak Sandra L; Wang Xinglong; Santos Maria S; Oliveira Catarina R; Tabaton Massimo; Nunomura Akihiko; Szweda Luke I; Aliev Gjumrakch; Smith Mark A; Zhu Xiongwei; Perry George
Increased autophagic degradation of mitochondria in Alzheimer disease.
Autophagy 2007;3(6):614-5.
2007: Alvira Daniel; Yeste-Velasco Marc; Folch Jaume; Casadesús Gemma; Smith Mark A; Pallàs Mercè; Camins Antoni
Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons.
Journal of neuroscience research 2007;85(14):3079-88.
2007: Webber Kate M; Perry George; Smith Mark A; Casadesus Gemma
The contribution of luteinizing hormone to Alzheimer disease pathogenesis.
Clinical medicine & research 2007;5(3):177-83.
2007: Liu Quan; Ju Won-Kyu; Crowston Jonathan G; Xie Fang; Perry George; Smith Mark A; Lindsey James D; Weinreb Robert N
Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage.
Investigative ophthalmology & visual science 2007;48(10):4580-9.
2007: Castellani Rudy J; Moreira Paula I; Liu Gang; Dobson Jon; Perry George; Smith Mark A; Zhu Xiongwei
Iron: the Redox-active center of oxidative stress in Alzheimer disease.
Neurochemical research 2007;32(10):1640-5.
2007: Moreira Paula I; Harris Peggy L R; Zhu Xiongwei; Santos Maria S; Oliveira Catarina R; Smith Mark A; Perry George
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.
Journal of Alzheimer's disease : JAD 2007;12(2):195-206.
2007: Pelegrí Carme; Canudas Anna Maria; del Valle Jaume; Casadesus Gemma; Smith Mark A; Camins Antoni; Pallàs Mercè; Vilaplana Jordi
Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence.
Mechanisms of ageing and development 2007;128(9):522-8.
2007: Zhu X; Su B; Wang X; Smith M A; Perry G
Causes of oxidative stress in Alzheimer disease.
Cellular and molecular life sciences : CMLS 2007;64(17):2202-10.
2007: Li Jie; Xia Xuechun; Ke Yibao; Nie Huiling; Smith Mark A; Zhu Xiongwei
Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways.
Biochimica et biophysica acta 2007;1770(8):1169-80.
2007: Moreira Paula I; Siedlak Sandra L; Wang Xinglong; Santos Maria S; Oliveira Catarina R; Tabaton Massimo; Nunomura Akihiko; Szweda Luke I; Aliev Gjumrakch; Smith Mark A; Zhu Xiongwei; Perry George
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Journal of neuropathology and experimental neurology 2007;66(6):525-32.
2007: Thakur Akanksha; Wang Xinglong; Siedlak Sandra L; Perry George; Smith Mark A; Zhu Xiongwei
c-Jun phosphorylation in Alzheimer disease.
Journal of neuroscience research 2007;85(8):1668-73.
2007: Zhu Xiongwei; Smith Mark A; Honda Kazuhiro; Aliev Gjumrakch; Moreira Paula I; Nunomura Akihiko; Casadesus Gemma; Harris Peggy L R; Siedlak Sandra L; Perry George
Vascular oxidative stress in Alzheimer disease.
Journal of the neurological sciences 2007;257(1-2):240-6.
2007: Lee Hyoung-gon; Zhu Xiongwei; Castellani Rudy J; Nunomura Akihiko; Perry George; Smith Mark A
Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses.
The Journal of pharmacology and experimental therapeutics 2007;321(3):823-9.
2007: Petersen Robert B; Nunomura Akihiko; Lee Hyoung-gon; Casadesus Gemma; Perry George; Smith Mark A; Zhu Xiongwei
Signal transduction cascades associated with oxidative stress in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2007;11(2):143-52.
2007: Castellani Rudy J; Zhu Xiongwei; Lee Hyoung-gon; Moreira Paula I; Perry George; Smith Mark A
Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
Expert review of neurotherapeutics 2007;7(5):473-85.
2007: Zhu Xiongwei; Avila Jesus; Perry George; Smith Mark A
Treating the lesions, not the disease.
The American journal of pathology 2007;170(5):1457-9.
2007: Casadesus Gemma; Milliken Erin L; Webber Kate M; Bowen Richard L; Lei Zhenmin; Rao C V; Perry George; Keri Ruth A; Smith Mark A
Increases in luteinizing hormone are associated with declines in cognitive performance.
Molecular and cellular endocrinology 2007;269(1-2):107-11.
2007: Casadesus Gemma; Moreira Paula I; Nunomura Akihiko; Siedlak Sandra L; Bligh-Glover William; Balraj Elizabeth; Petot Grace; Smith Mark A; Perry George
Indices of metabolic dysfunction and oxidative stress.
Neurochemical research 2007;32(4-5):717-22.
2007: Woods Jack; Snape Mike; Smith Mark A
The cell cycle hypothesis of Alzheimer's disease: suggestions for drug development.
Biochimica et biophysica acta 2007;1772(4):503-8.
2007: Zhu Xiongwei; Lee Hyoung-gon; Perry George; Smith Mark A
Alzheimer disease, the two-hit hypothesis: an update.
Biochimica et biophysica acta 2007;1772(4):494-502.
2007: McShea Andrew; Lee Hyoung-gon; Petersen Robert B; Casadesus Gemma; Vincent Inez; Linford Nancy J; Funk Jens-Oliver; Shapiro Robert A; Smith Mark A
Neuronal cell cycle re-entry mediates Alzheimer disease-type changes.
Biochimica et biophysica acta 2007;1772(4):467-72.
2007: Previll Laura A; Crosby Meredith E; Castellani Rudy J; Bowser Robert; Perry George; Smith Mark A; Zhu Xiongwei
Increased expression of p130 in Alzheimer disease.
Neurochemical research 2007;32(4-5):639-44.
2007: Wung John K; Perry George; Kowalski Aaron; Harris Peggy L R; Bishop Glenda M; Trivedi Mehul A; Johnson Sterling C; Smith Mark A; Denhardt David T; Atwood Craig S
Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain.
Current Alzheimer research 2007;4(1):67-72.
2007: Liu Quan; Xie Fang; Rolston Raj; Moreira Paula I; Nunomura Akihiko; Zhu Xiongwei; Smith Mark A; Perry George
Prevention and treatment of Alzheimer disease and aging: antioxidants.
Mini reviews in medicinal chemistry 2007;7(2):171-80.
2007: Webber Kate M; Casadesus Gemma; Atwood Craig S; Bowen Richard L; Perry George; Smith Mark A
Gonadotropins: a cohesive gender-based etiology of Alzheimer disease.
Molecular and cellular endocrinology 2007;260-262():271-5.
2007: Li Jie; Xia Xuechun; Nie Huiling; Smith Mark A; Zhu Xiongwei
PKC inhibition is involved in trichosanthin-induced apoptosis in human chronic myeloid leukemia cell line K562.
Biochimica et biophysica acta 2007;1770(1):63-70.
2007: Nunomura A; Moreira P I; Takeda A; Smith M A; Perry G
Oxidative RNA damage and neurodegeneration.
Current medicinal chemistry 2007;14(28):2968-75.
2007: Bishop Glenda M; Smith Mark A; LaManna Joseph C; Wilson Andrea C; Perry George; Atwood Craig S
Iron homeostasis is maintained in the brain, but not the liver, following mild hypoxia.
Redox report : communications in free radical research 2007;12(6):257-66.
2007: Gonzalez-Cuyar Luis F; Hunter Brian; Harris Peggy L R; Perry George; Smith Mark A; Castellani Rudy J
Cerebrotendinous xanthomatosis: case report with evidence of oxidative stress.
Redox report : communications in free radical research 2007;12(3):119-24.
2007: Evans Teresa A; Raina Arun K; Delacourte André; Aprelikova Olga; Lee Hyoung-gon; Zhu Xiongwei; Perry George; Smith Mark A
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
International journal of medical sciences 2007;4(3):140-5.
2007: Casadesus Gemma; Smith Mark A; Basu Samar; Hua Jing; Capobianco Dae E; Siedlak Sandra L; Zhu Xiongwei; Perry George
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease.
Molecular neurodegeneration 2007;2():2.
2006: Lee Hyoung-gon; Ueda Masumi; Miyamoto Yoichi; Yoneda Yoshihiro; Perry George; Smith Mark A; Zhu Xiongwei
Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease.
Brain research 2006;1124(1):1-4.
2006: Lee Hyoung-gon; Ueda Masumi; Zhu Xiongwei; Perry George; Smith Mark A
Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
Journal of neuroscience research 2006;84(8):1856-61.
2006: Lam-Himlin Dora; Espey Michael G; Perry George; Smith Mark A; Castellani Rudy J
Malignant glioma progression and nitric oxide.
Neurochemistry international 2006;49(8):764-8.
2006: McShea Andrew; Marlatt Michael W; Lee Hyoung-Gon; Tarkowsky Stephanie M; Smit Mariya; Smith Mark A
The application of microarray technology to neuropathology: cutting edge tool with clinical diagnostics potential or too much information?
Journal of neuropathology and experimental neurology 2006;65(11):1031-9.
2006: Zhu Xiongwei; Siedlak Sandra L; Smith Mark A; Perry George; Chen Shu G
LRRK2 protein is a component of Lewy bodies.
Annals of neurology 2006;60(5):617-8; author reply 618-9.
2006: Strocchi Paola; Smith Mark A; Perry George; Tamagno Elena; Danni Oliviero; Pession Annalisa; Gaiba Alessia; Dozza Barbara
Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells.
Neurobiology of aging 2006;27(11):1588-94.
2006: Smith Mark A; Perry George
Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Therapeutic strategies for Alzheimer's disease: The need for a new era of innovation.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(4):294-5.
2006: Zhu Xiongwei; Raina Arun K; Perry George; Smith Mark A
Apoptosis in Alzheimer disease: a mathematical improbability.
Current Alzheimer research 2006;3(4):393-6.
2006: Lee Hyoung-gon; Zhu Xiongwei; Nunomura Akihiko; Perry George; Smith Mark A
Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose!
The American journal of pathology 2006;169(3):738-9.
2006: Obrenovich Mark E; Smith Mark A; Siedlak Sandra L; Chen Shu G; de la Torre Jack C; Perry George; Aliev Gjumrakch
Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions.
Neurotoxicity research 2006;10(1):43-56.
2006: Franco Sonia; Blasco Maria A; Siedlak Sandra L; Harris Peggy L R; Moreira Paula I; Perry George; Smith Mark A
Telomeres and telomerase in Alzheimer's disease: Epiphenomena or a new focus for therapeutic strategy?
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(3):164-8.
2006: Sparks D L; Friedland R; Petanceska S; Schreurs B G; Shi J; Perry G; Smith M A; Sharma A; Derosa S; Ziolkowski C; Stankovic G
Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology.
The journal of nutrition, health & aging 2006;10(4):247-54.
2006: Zhu Xiongwei; Perry George; Moreira Paula I; Aliev Gjumrakch; Cash Adam D; Hirai Keisuke; Smith Mark A
Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease.
Journal of Alzheimer's disease : JAD 2006;9(2):147-53.
2006: Nunomura Akihiko; Castellani Rudy J; Zhu Xiongwei; Moreira Paula I; Perry George; Smith Mark A
Involvement of oxidative stress in Alzheimer disease.
Journal of neuropathology and experimental neurology 2006;65(7):631-41.
2006: Lee Hyoung-gon; Perry George; Zhu Xiongwei; Nunomura Akihiko; Smith Mark A
Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression".
Free radical biology & medicine 2006;41(2):188-9.
2006: Lee Hyoung-gon; Zhu Xiongwei; Takeda Atsushi; Perry George; Smith Mark A
Emerging evidence for the neuroprotective role of alpha-synuclein.
Experimental neurology 2006;200(1):1-7.
2006: Aliev G; Miller J P; Leifer D W; Obrenovich M E; Shenk J C; Smith M A; Lamanna J C; Perry G; Lust D W; Cohen A R
Ultrastructural analysis of a murine model of congenital hydrocephalus produced by overexpression of transforming growth factor-beta1 in the central nervous system.
Journal of submicroscopic cytology and pathology 2006;38(2-3):85-91.
2006: Moreira Paula I; Zhu Xiongwei; Nunomura Akihiko; Smith Mark A; Perry George
Therapeutic options in Alzheimer's disease.
Expert review of neurotherapeutics 2006;6(6):897-910.
2006: Castellani Rudy J; Lee Hyoung-Gon; Zhu Xiongwei; Nunomura Akihiko; Perry George; Smith Mark A
Neuropathology of Alzheimer disease: pathognomonic but not pathogenic.
Acta neuropathologica 2006;111(6):503-9.
2006: Moreira Paula I; Zhu Xiongwei; Lee Hyoung-Gon; Honda Kazuhiro; Smith Mark A; Perry George
The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease.
Mechanisms of ageing and development 2006;127(6):501-6.
2006: Nunomura Akihiko; Castellani Rudy J; Lee Hyoung-Gon; Moreira Paula I; Zhu Xiongwei; Perry George; Smith Mark A
Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.
Science of aging knowledge environment : SAGE KE 2006;2006(8):pe10.
2006: Hasegawa Takafumi; Matsuzaki-Kobayashi Michiko; Takeda Atsushi; Sugeno Naoto; Kikuchi Akio; Furukawa Katsutoshi; Perry George; Smith Mark A; Itoyama Yasuto
Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease.
FEBS letters 2006;580(8):2147-52.
2006: Casadesus Gemma; Webber Kate M; Atwood Craig S; Pappolla Miguel A; Perry George; Bowen Richard L; Smith Mark A
Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice.
Biochimica et biophysica acta 2006;1762(4):447-52.
2006: Castellani Rudy J; Lee Hyoung-Gon; Perry George; Smith Mark A
Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau.
American journal of Alzheimer's disease and other dementias 2006;21(2):126-30.
2006: Zhu Xiongwei; Lee Hyoung-Gon; Moreira Paula I; Smith Mark A; Perry George
Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".
Free radical biology & medicine 2006;40(5):737-9.
2006: Lee Hyoung-gon; Zhu Xiongwei; Nunomura Akihiko; Perry George; Smith Mark A
Amyloid beta: the alternate hypothesis.
Current Alzheimer research 2006;3(1):75-80.
2006: Moreira P I; Honda K; Zhu X; Nunomura A; Casadesus G; Smith M A; Perry G
Brain and brawn: parallels in oxidative strength.
Neurology 2006;66(2 Suppl 1):S97-101.
2006: Zhu Xiongwei; Babar Asim; Siedlak Sandra L; Yang Qiwei; Ito Genta; Iwatsubo Takeshi; Smith Mark A; Perry George; Chen Shu G
LRRK2 in Parkinson's disease and dementia with Lewy bodies.
Molecular neurodegeneration 2006;1():17.
2006: Nunomura Akihiko; Honda Kazuhiro; Takeda Atsushi; Hirai Keisuke; Zhu Xiongwei; Smith Mark A; Perry George
Oxidative damage to RNA in neurodegenerative diseases.
Journal of biomedicine & biotechnology 2006;2006(3):82323.
2006: Smith Mark A; Perry George; Zhu Xiongwei; Haoudi Abdelali
Neurodegenerative diseases: mechanisms and therapies.
Journal of biomedicine & biotechnology 2006;2006(3):47539.
2006: Casadesus Gemma; Puig Emma Ramiro; Webber Kate M; Atwood Craig S; Escuer Margarida Castell; Bowen Richard L; Perry George; Smith Mark A
Targeting gonadotropins: an alternative option for Alzheimer disease treatment.
Journal of biomedicine & biotechnology 2006;2006(3):39508.
2006: Dwyer Barney E; Stone Meghan L; Zhu Xiongwei; Perry George; Smith Mark A
Heme deficiency in Alzheimer's disease: a possible connection to porphyria.
Journal of biomedicine & biotechnology 2006;2006(3):24038.
2006: Webber Kate M; Stocco Douglas M; Casadesus Gemma; Bowen Richard L; Atwood Craig S; Previll Laura A; Harris Peggy L R; Zhu Xiongwei; Perry George; Smith Mark A
Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease.
Molecular neurodegeneration 2006;1():14.
2006: Smith Mark A
Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss!
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):305-8.
2006: Casadesus Gemma; Garrett Matthew R; Webber Kate M; Hartzler Anthony W; Atwood Craig S; Perry George; Bowen Richard L; Smith Mark A
The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease.
Drugs in R&D 2006;7(3):187-93.
2006: Moreira Paula I; Zhu Xiongwei; Liu Quan; Honda Kazuhiro; Siedlak Sandra L; Harris Peggy L; Smith Mark A; Perry George
Compensatory responses induced by oxidative stress in Alzheimer disease.
Biological research 2006;39(1):7-13.
2006: Lee Hyoung-gon; Zhu Xiongwei; Perry George; Smith Mark A
The fallacy of amyloid and cognition in Alzheimer's disease.
Drugs & aging 2006;23(2):179.
2006: Webber Kate M; Casadesus Gemma; Zhu Xiongwei; Obrenovich Mark E; Atwood Craig S; Perry George; Bowen Richard L; Smith Mark A
The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target.
Current pharmaceutical design 2006;12(6):691-7.
2006: Gregory Christopher W; Atwood Craig S; Smith Mark A; Bowen Richard L
Antigonadotropins: a novel strategy to halt Alzheimer's disease progression.
Current pharmaceutical design 2006;12(6):685-90.
2005: Ma Yi Long; Zhu Xiongwei; Rivera Patricia M; Tøien Øivind; Barnes Brian M; LaManna Joseph C; Smith Mark A; Drew Kelly L
Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(5):R1297-306.
2005: Castellani Rudy J; Siedlak Sandra L; Fortino Anne E; Perry George; Ghetti Bernardino; Smith Mark A
Chitin-like polysaccharides in Alzheimer's disease brains.
Current Alzheimer research 2005;2(4):419-23.
2005: Moreira Paula I; Honda Kazuhiro; Liu Quan; Santos Maria S; Oliveira Catarina R; Aliev Gjumrakch; Nunomura Akihiko; Zhu Xiongwei; Smith Mark A; Perry George
Oxidative stress: the old enemy in Alzheimer's disease pathophysiology.
Current Alzheimer research 2005;2(4):403-8.
2005: Santa-María Ismael; Hernández Félix; Smith Mark A; Perry George; Avila Jesús; Moreno Francisco J
Neurotoxic dopamine quinone facilitates the assembly of tau into fibrillar polymers.
Molecular and cellular biochemistry 2005;278(1-2):203-12.
2005: Webber Kate M; Raina Arun K; Marlatt Michael W; Zhu Xiongwei; Prat María I; Morelli Laura; Casadesus Gemma; Perry George; Smith Mark A
The cell cycle in Alzheimer disease: a unique target for neuropharmacology.
Mechanisms of ageing and development 2005;126(10):1019-25.
2005: Yu Xiaoyi; Caltagarone John; Smith Mark A; Bowser Robert
DNA damage induces cdk2 protein levels and histone H2B phosphorylation in SH-SY5Y neuroblastoma cells.
Journal of Alzheimer's disease : JAD 2005;8(1):7-21.
2005: Petersen Robert B; Siedlak Sandra L; Lee Hyoung-gon; Kim Yong-Sun; Nunomura Akihiko; Tagliavini Fabrizio; Ghetti Bernardino; Cras Patrick; Moreira Paula I; Castellani Rudy J; Guentchev Marin; Budka Herbert; Ironside James W; Gambetti Pierluigi; Smith Mark A; Perry George
Redox metals and oxidative abnormalities in human prion diseases.
Acta neuropathologica 2005;110(3):232-8.
2005: Zhu Xiongwei; Moreira Paula I; Smith Mark A; Perry George
Alzheimer's disease: an intracellular movement disorder?
Trends in molecular medicine 2005;11(9):391-3.
2005: Lin De; Lee Hyoung-gon; Liu Quan; Perry George; Smith Mark A; Sayre Lawrence M
4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal.
Chemical research in toxicology 2005;18(8):1219-31.
2005: Hagemann Tracy L; Gaeta Stephen A; Smith Mark A; Johnson Delinda A; Johnson Jeffrey A; Messing Albee
Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction.
Human molecular genetics 2005;14(16):2443-58.
2005: Casadesus Gemma; Smith Mark A; Perry George
Commentary: "Ceramide and cholesterol: Possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" By Claudio Costantini, Rekha M.K. Kolasani, and Luigi Puglielli.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2005;1(1):51-2.
2005: Dwyer Barney E; Takeda Atsushi; Zhu Xiongwei; Perry George; Smith Mark A
Ferric cycle activity and Alzheimer disease.
Current neurovascular research 2005;2(3):261-7.
2005: Moreira P I; Siedlak S L; Aliev G; Zhu X; Cash A D; Smith M A; Perry G
Oxidative stress mechanisms and potential therapeutics in Alzheimer disease.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(7):921-32.
2005: Zhu Xiongwei; Mei Matthew; Lee Hyoung-Gon; Wang Yang; Han Jiahuai; Perry George; Smith Mark A
P38 activation mediates amyloid-beta cytotoxicity.
Neurochemical research 2005;30(6-7):791-6.
2005: Moreira Paula I; Smith Mark A; Zhu Xiongwei; Nunomura Akihiko; Castellani Rudy J; Perry George
Oxidative stress and neurodegeneration.
Annals of the New York Academy of Sciences 2005;1043():545-52.
2005: Webber Kate M; Casadesus Gemma; Marlatt Michael W; Perry George; Hamlin Clive R; Atwood Craig S; Bowen Richard L; Smith Mark A
Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis.
Annals of the New York Academy of Sciences 2005;1052():201-9.
2005: Santa-María Ismael; Smith Mark A; Perry George; Hernández Félix; Avila Jesús; Moreno Francisco J
Effect of quinones on microtubule polymerization: a link between oxidative stress and cytoskeletal alterations in Alzheimer's disease.
Biochimica et biophysica acta 2005;1740(3):472-80.
2005: Lee Hyoung-Gon; Castellani Rudy J; Zhu Xiongwei; Perry George; Smith Mark A
Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?
International journal of experimental pathology 2005;86(3):133-8.
2005: Zhu Xiongwei; Smith Mark A; Perry George; Wang Yang; Ross Austin P; Zhao Huiwen W; Lamanna Joseph C; Drew Kelly L
MAPKs are differentially modulated in arctic ground squirrels during hibernation.
Journal of neuroscience research 2005;80(6):862-8.
2005: Honda Kazuhiro; Smith Mark A; Zhu Xiongwei; Baus Diane; Merrick William C; Tartakoff Alan M; Hattier Thomas; Harris Peggy L; Siedlak Sandra L; Fujioka Hisashi; Liu Quan; Moreira Paula I; Miller Frank P; Nunomura Akihiko; Shimohama Shun; Perry George
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
The Journal of biological chemistry 2005;280(22):20978-86.
2005: Reddy V Prakash; Garrett Matthew R; Perry George; Smith Mark A
Carnosine: a versatile antioxidant and antiglycating agent.
Science of aging knowledge environment : SAGE KE 2005;2005(18):pe12.
2005: Smith Mark A; Nunomura Akihiko; Lee Hyoung-gon; Zhu Xiongwei; Moreira Paula I; Avila Jesús; Perry George
Chronological primacy of oxidative stress in Alzheimer disease.
Neurobiology of aging 2005;26(5):579-80.
2005: Moreira Paula I; Oliveira Catarina R; Santos Maria S; Nunomura Akihiko; Honda Kazuhiro; Zhu Xiongwei; Smith Mark A; Perry George
A second look into the oxidant mechanisms in Alzheimer's disease.
Current neurovascular research 2005;2(2):179-84.
2005: Meethal Sivan Vadakkadath; Smith Mark A; Bowen Richard L; Atwood Craig S
The gonadotropin connection in Alzheimer's disease.
Endocrine 2005;26(3):317-26.
2005: Webber Kate M; Casadesus Gemma; Perry George; Atwood Craig S; Bowen Richard; Smith Mark A
Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesis.
Alzheimer disease and associated disorders 2005;19(2):95-9.
2005: Zaidi Syed I A; Richardson Sandra L; Capellari Sabina; Song Li; Smith Mark A; Ghetti Bernardino; Sy Man-Sun; Gambetti Pierluigi; Petersen Robert B
Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding.
Journal of Alzheimer's disease : JAD 2005;7(2):159-71; discussion 173-80.
2005: Lee Hyoung-Gon; Perry George; Moreira Paula I; Garrett Matthew R; Liu Quan; Zhu Xiongwei; Takeda Atsushi; Nunomura Akihiko; Smith Mark A
Tau phosphorylation in Alzheimer's disease: pathogen or protector?
Trends in molecular medicine 2005;11(4):164-9.
2005: Casadesus Gemma; Shukitt-Hale Barbara; Stellwagen Heather M; Smith Mark A; Rabin Bernard M; Joseph James A
Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats.
Experimental gerontology 2005;40(3):249-54.
2005: Aliyev Ali; Chen Shu G; Seyidova Dilara; Smith Mark A; Perry George; de la Torre Jack; Aliev Gjumrakch
Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease.
Journal of the neurological sciences 2005;229-230():285-92.
2005: Liu Quan; Smith Mark A; Avilá Jesus; DeBernardis John; Kansal Mayank; Takeda Atsushi; Zhu Xiongwei; Nunomura Akihiko; Honda Kazuhiro; Moreira Paula I; Oliveira Catarina R; Santos Maria S; Shimohama Shun; Aliev Gjumrakch; de la Torre Jack; Ghanbari Hossein A; Siedlak Sandra L; Harris Peggy L R; Sayre Lawrence M; Perry George
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations.
Free radical biology & medicine 2005;38(6):746-54.
2005: Atwood Craig S; Meethal Sivan Vadakkadath; Liu Tianbing; Wilson Andrea C; Gallego Miguel; Smith Mark A; Bowen Richard L
Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence.
Journal of neuropathology and experimental neurology 2005;64(2):93-103.
2005: Zhu Xiongwei; Perry George; Smith Mark A
Insulin signaling, diabetes mellitus and risk of Alzheimer disease.
Journal of Alzheimer's disease : JAD 2005;7(1):81-4.
2005: Atwood Craig S; Smith Mark A; Bowen Richard L
Feedback on a feedback loop: the hypothalamic-pituitary-gonadal axis.
Journal of Alzheimer's disease : JAD 2005;7(1):1-2.
2005: Casadesus G; Atwood C S; Zhu X; Hartzler A W; Webber K M; Perry G; Bowen R L; Smith M A
Evidence for the role of gonadotropin hormones in the development of Alzheimer disease.
Cellular and molecular life sciences : CMLS 2005;62(3):293-8.
2005: Bowen Richard L; Martins Ralph N; Gregory Christopher W; Smith Mark A; Atwood Craig S
Dementia and testosterone levels in men.
JAMA : the journal of the American Medical Association 2005;293(5):551; author reply 552.
2005: Mustata Georgian T; Rosca Mariana; Biemel Klaus M; Reihl Oliver; Smith Mark A; Viswanathan Ashwini; Strauch Christopher; Du Yunpeng; Tang Jie; Kern Timothy S; Lederer Markus O; Brownlee Michael; Weiss Miriam F; Monnier Vincent M
Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking.
Diabetes 2005;54(2):517-26.
2005: Tamagno Elena; Parola Maurizio; Bardini Paola; Piccini Alessandra; Borghi Roberta; Guglielmotto Michela; Santoro Gianni; Davit Annalisa; Danni Oliviero; Smith M A; Perry G; Tabaton Massimo
Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.
Journal of neurochemistry 2005;92(3):628-36.
2005: Webber Kate M; Smith Mark A; Lee Hyoung-gon; Harris Peggy L; Moreira Paula; Perry George; Zhu Xiongwei
Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
Journal of neuroscience research 2005;79(4):554-60.
2005: Moreira Paula I; Smith Mark A; Zhu Xiongwei; Honda Kazuhiro; Lee Hyoung-Gon; Aliev Gjumrakch; Perry George
Oxidative damage and Alzheimer's disease: are antioxidant therapies useful?
Drug news & perspectives 2005;18(1):13-9.
2005: Liu Quan; Lee Hyoung-gon; Honda Kazuhiro; Siedlak Sandra L; Harris Peggy L R; Cash Adam D; Zhu Xiongwei; Avila Jesús; Nunomura Akihiko; Takeda Atsushi; Smith Mark A; Perry George
Tau modifiers as therapeutic targets for Alzheimer's disease.
Biochimica et biophysica acta 2005;1739(2-3):211-5.
2005: Sayre Lawrence M; Moreira Paula I; Smith Mark A; Perry George
Metal ions and oxidative protein modification in neurological disease.
Annali dell'Istituto superiore di sanità 2005;41(2):143-64.
2005: Zhu Xiongwei; Lee Hyoung-Gon; Casadesus Gemma; Avila Jesus; Drew Kelly; Perry George; Smith Mark A
Oxidative imbalance in Alzheimer's disease.
Molecular neurobiology 2005;31(1-3):205-17.
2005: Sahin M; Karauzum S B; Perry G; Smith M A; Aliciguzel Y
Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration.
Neurotoxicity research 2005;7(3):243-50.
2005: Marlatt Michael W; Webber Kate M; Moreira Paula I; Lee Hyoung-gon; Casadesus Gemma; Honda Kazuhiro; Zhu Xiongwei; Perry George; Smith Mark A
Therapeutic opportunities in Alzheimer disease: one for all or all for one?
Current medicinal chemistry 2005;12(10):1137-47.
2004: Liu Q; Xie F; Siedlak S L; Nunomura A; Honda K; Moreira P I; Zhua X; Smith M A; Perry G
Neurofilament proteins in neurodegenerative diseases.
Cellular and molecular life sciences : CMLS 2004;61(24):3057-75.
2004: Moreira Paula I; Smith Mark A; Zhu Xiongwei; Santos Maria S; Oliveira Catarina R; Perry George
Therapeutic potential of oxidant mechanisms in Alzheimer's disease.
Expert review of neurotherapeutics 2004;4(6):995-1004.
2004: Zhu Xiongwei; Smith Mark A; Perry George; Aliev Gjumrakch
Mitochondrial failures in Alzheimer's disease.
American journal of Alzheimer's disease and other dementias 2004;19(6):345-52.
2004: Lee Hyoung-Gon; Moreira Paula I; Zhu Xiongwei; Smith Mark A; Perry George
Staying connected: synapses in Alzheimer disease.
The American journal of pathology 2004;165(5):1461-4.
2004: Casadesus Gemma; Shukitt-Hale Barbara; Stellwagen Heather M; Zhu Xiongwei; Lee Hyoung-Gon; Smith Mark A; Joseph James A
Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats.
Nutritional neuroscience 2004;7(5-6):309-16.
2004: Nunomura Akihiko; Chiba Shigeru; Lippa Carol F; Cras Patrick; Kalaria Rajesh N; Takeda Atsushi; Honda Kazuhiro; Smith Mark A; Perry George
Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease.
Neurobiology of disease 2004;17(1):108-13.
2004: Takeda Atsushi; Itoyama Yasuto; Kimpara Teiko; Zhu Xiongwei; Avila Jesús; Dwyer Barney E; Perry George; Smith Mark A
Heme catabolism and heme oxygenase in neurodegenerative disease.
Antioxidants & redox signaling 2004;6(5):888-94.
2004: Aliev Gjumrakch; Smith Mark A; de la Torre Jack C; Perry George
Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease.
Mitochondrion 2004;4(5-6):649-63.
2004: Moreira Paula I; Liu Quan; Honda Kazuhiro; Smith Mark A; Santos Maria S; Oliveira Catarina R
Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology?
Journal of Alzheimer's disease : JAD 2004;6(4):433-4; discussion 443-9.
2004: Casadesus Gemma; Zhu Xiongwei; Atwood Craig S; Webber Kate M; Perry George; Bowen Richard L; Smith Mark A
Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease.
Current drug targets. CNS and neurological disorders 2004;3(4):281-5.
2004: Drew K L; Harris M B; LaManna J C; Smith M A; Zhu X W; Ma Y L
Hypoxia tolerance in mammalian heterotherms.
The Journal of experimental biology 2004;207(Pt 18):3155-62.
2004: Zhu X; Webber K M; Casadesus G; Raina A K; Lee H G; Marlatt M; Hartzler A; Atwood C S; Perry G; Smith M A
Mitotic and gender parallels in Alzheimer disease: therapeutic opportunities.
Current drug targets 2004;5(6):559-63.
2004: Ma Yi Long; Rice Margaret E; Chao Mei Lan; Rivera Patricia M; Zhao Huiwen W; Ross Austin P; Zhu Xiongwei; Smith Mark A; Drew Kelly L
Ascorbate distribution during hibernation is independent of ascorbate redox state.
Free radical biology & medicine 2004;37(4):511-20.
2004: Aliev G; Castellani R J; Petersen R B; Burnstock G; Perry G; Smith M A
Pathobiology of familial hypercholesterolemic atherosclerosis.
Journal of submicroscopic cytology and pathology 2004;36(3-4):225-40.
2004: Aliyev Ali; Seyidova Dilara; Rzayev Nizami; Obrenovich Mark E; Lamb Bruce T; Chen Shu G; Smith Mark A; Perry George; de la Torre Jack C; Aliev Gjumrakch
Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?
Neurological research 2004;26(5):547-53.
2004: Castellani Rudy J; Honda Kazuhiro; Zhu Xiongwei; Cash Adam D; Nunomura Akihiko; Perry George; Smith Mark A
Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease.
Ageing research reviews 2004;3(3):319-26.
2004: Hasegawa Takafumi; Matsuzaki Michiko; Takeda Atsushi; Kikuchi Akio; Akita Hirotoshi; Perry George; Smith Mark A; Itoyama Yasuto
Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells.
Brain research 2004;1013(1):51-9.
2004: Lee Hyoung-Gon; Casadesus Gemma; Zhu Xiongwei; Takeda Atsushi; Perry George; Smith Mark A
Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease.
Annals of the New York Academy of Sciences 2004;1019():1-4.
2004: Zhu Xiongwei; Wang Yang; Ogawa Osamu; Lee Hyoung-gon; Raina Arun K; Siedlak Sandra L; Harris Peggy L R; Fujioka Hisashi; Shimohama Shun; Tabaton Massimo; Atwood Craig S; Petersen Robert B; Perry George; Smith Mark A
Neuroprotective properties of Bcl-w in Alzheimer disease.
Journal of neurochemistry 2004;89(5):1233-40.
2004: Dozza Barbara; Smith Mark A; Perry George; Tabaton Massimo; Strocchi Paola
Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells.
Journal of neurochemistry 2004;89(5):1224-32.
2004: Dwyer Barney E; Raina Arun K; Perry George; Smith Mark A
Homocysteine and Alzheimer's disease: a modifiable risk?
Free radical biology & medicine 2004;36(11):1471-5.
2004: Avila Jesús; Pérez Mar; Lucas José J; Gómez-Ramos Alberto; Santa María Ismael; Moreno Francisco; Smith Mark; Perry George; Hernández Félix
Assembly in vitro of tau protein and its implications in Alzheimer's disease.
Current Alzheimer research 2004;1(2):97-101.
2004: Seyidova Dilara; Aliyev Ali; Rzayev Nizami; Obrenovich Mark; Lamb Bruce T; Smith Mark A; de la Torre Jack C; Perry George; Aliev Gjumrakch
The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease.
In vivo (Athens, Greece) 2004;18(3):325-33.
2004: Castellani Rudy J; Smith Mark A; Perry George; Friedland Robert P
Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis.
Neurobiology of aging 2004;25(5):599-602; discussion 603-4.
2004: Bowen Richard L; Verdile Giuseppe; Liu Tianbing; Parlow Albert F; Perry George; Smith Mark A; Martins Ralph N; Atwood Craig S
Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.
The Journal of biological chemistry 2004;279(19):20539-45.
2004: Casadesus Gemma; Smith Mark A; Zhu Xiongwei; Aliev Gjumrakch; Cash Adam D; Honda Kazuhiro; Petersen Robert B; Perry George
Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species.
Journal of Alzheimer's disease : JAD 2004;6(2):165-9.
2004: Lee Hyoung-gon; Casadesus Gemma; Zhu Xiongwei; Joseph James A; Perry George; Smith Mark A
Perspectives on the amyloid-beta cascade hypothesis.
Journal of Alzheimer's disease : JAD 2004;6(2):137-45.
2004: Zhu Xiongwei; Raina Arun K; Perry George; Smith Mark A
Alzheimer's disease: the two-hit hypothesis.
Lancet neurology 2004;3(4):219-26.
2004: Lee Hyoung-gon; Ogawa Osamu; Zhu Xiongwei; O'Neill Michael J; Petersen Robert B; Castellani Rudolph J; Ghanbari Hossein; Perry George; Smith Mark A
Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
Acta neuropathologica 2004;107(4):365-71.
2004: Honda Kazuhiro; Casadesus Gemma; Petersen Robert B; Perry George; Smith Mark A
Oxidative stress and redox-active iron in Alzheimer's disease.
Annals of the New York Academy of Sciences 2004;1012():179-82.
2004: Zhu Xiongwei; Raina Arun K; Lee Hyoung-Gon; Casadesus Gemma; Smith Mark A; Perry George
Oxidative stress signalling in Alzheimer's disease.
Brain research 2004;1000(1-2):32-9.
2004: Zhu Xiongwei; McShea Andrew; Harris Peggy L R; Raina Arun K; Castellani Rudy J; Funk Jens Oliver; Shah Sapan; Atwood Craig; Bowen Richard; Bowser Robert; Morelli Laura; Perry George; Smith Mark A
Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease.
Journal of neuroscience research 2004;75(5):698-703.
2004: Vitali Antonella; Piccini Alessandra; Borghi Roberta; Fornaro Pantaleo; Siedlak Sandra L; Smith Mark A; Gambetti Pierluigi; Ghetti Bernardino; Tabaton Massimo
Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations.
Journal of Alzheimer's disease : JAD 2004;6(1):45-51.
2004: Ghanbari Hossein A; Ghanbari Kasra; Harris Peggy L R; Jones Paul K; Kubat Zvezdana; Castellani Rudolph J; Wolozin Benjamin L; Smith Mark A; Perry George
Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients.
Aging cell 2004;3(1):41-4.
2004: Liu Tianbing; Perry George; Chan Hsien W; Verdile Giuseppe; Martins Ralph N; Smith Mark A; Atwood Craig S
Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression.
Journal of neurochemistry 2004;88(3):554-63.
2004: Wilson C; Henry S; Smith M A; Bowser R
The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain.
Neuropathology and applied neurobiology 2004;30(1):19-29.
2004: Atwood Craig S; Perry George; Zeng Hong; Kato Yoji; Jones Walton D; Ling Ke-Qing; Huang Xudong; Moir Robert D; Wang Dandan; Sayre Lawrence M; Smith Mark A; Chen Shu G; Bush Ashley I
Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta.
Biochemistry 2004;43(2):560-8.
2004: Webber Kate M; Bowen Richard; Casadesus Gemma; Perry George; Atwood Craig S; Smith Mark A
Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotection.
Acta neurobiologiae experimentalis 2004;64(1):113-8.
2004: Raina Arun K; Zhu Xiongwei; Smith Mark A
Alzheimer's disease and the cell cycle.
Acta neurobiologiae experimentalis 2004;64(1):107-12.
2004: Lee Hyoung-gon; Zhu Xiongwei; O'Neill Michael J; Webber Kate; Casadesus Gemma; Marlatt Michael; Raina Arun K; Perry George; Smith Mark A
The role of metabotropic glutamate receptors in Alzheimer's disease.
Acta neurobiologiae experimentalis 2004;64(1):89-98.
2004: Marlatt Michael; Lee Hyoung-gon; Perry George; Smith Mark A; Zhu Xiongwei
Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease.
Acta neurobiologiae experimentalis 2004;64(1):81-7.
2004: Gómez-Ramos Alberto; Smith Mark A; Perry George; Avila Jesús
Tau phosphorylation and assembly.
Acta neurobiologiae experimentalis 2004;64(1):33-9.
2004: Castellani Rudy J; Perry George; Smith Mark A
Prion disease and Alzheimer's disease: pathogenic overlap.
Acta neurobiologiae experimentalis 2004;64(1):11-7.
2003: Perry George; Castellani Rudy J; Smith Mark A; Harris Peggy L R; Kubat Zvezdana; Ghanbari Kasra; Jones Paul K; Cordone Giovanni; Tabaton Massimo; Wolozin Benjamin; Ghanbari Hossein
Oxidative damage in the olfactory system in Alzheimer's disease.
Acta neuropathologica 2003;106(6):552-6.
2003: Lee Hyoung-gon; Petersen Robert B; Zhu Xiongwei; Honda Kazuhiro; Aliev Gjumrakch; Smith Mark A; Perry George
Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases?
Brain pathology (Zurich, Switzerland) 2003;13(4):630-8.
2003: Zhu Xiongwei; Raina Arun K; Lee Hyoung-Gon; Chao Mark; Nunomura Akihiko; Tabaton Massimo; Petersen Robert B; Perry George; Smith Mark A
Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways.
Antioxidants & redox signaling 2003;5(5):571-6.
2003: Perry George; Nunomura Akihiko; Raina Arun K; Aliev Gjumrakch; Siedlak Sandra L; Harris Peggy L R; Casadesus Gemma; Petersen Robert B; Bligh-Glover William; Balraj Elizabeth; Petot Grace J; Smith Mark A
A metabolic basis for Alzheimer disease.
Neurochemical research 2003;28(10):1549-52.
2003: Aliev Gjumrakch; Seyidova Dilara; Lamb Bruce T; Obrenovich Mark E; Siedlak Sandra L; Vinters Harry V; Friedland Robert P; LaManna Joseph C; Smith Mark A; Perry George
Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice.
Neurological research 2003;25(6):665-74.
2003: Atwood Craig S; Bowen Richard L; Smith Mark A; Perry George
Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply.
Brain research. Brain research reviews 2003;43(1):164-78.
2003: Atwood Craig S; Obrenovich Mark E; Liu Tianbing; Chan Hsien; Perry George; Smith Mark A; Martins Ralph N
Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta.
Brain research. Brain research reviews 2003;43(1):1-16.
2003: Liu Quan; Raina Arun K; Smith Mark A; Sayre Lawrence M; Perry George
Hydroxynonenal, toxic carbonyls, and Alzheimer disease.
Molecular aspects of medicine 2003;24(4-5):305-13.
2003: Kitamura Yoshihisa; Tsuchiya Daiju; Takata Kazuyuki; Shibagaki Keiichi; Taniguchi Takashi; Smith Mark A; Perry George; Miki Hiroaki; Takenawa Tadaomi; Shimohama Shun
Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease.
Neuroscience letters 2003;346(3):149-52.
2003: Aliev G; Obrenovich M E; Seyidova D; Rzayev N M; Aliyev A S; Raina A K; Lamanna J C; Smith M A; Perry G
X-ray contrast media induce aortic endothelial damage, which can be prevented with prior heparin treatment.
Journal of submicroscopic cytology and pathology 2003;35(3):253-66.
2003: Zhu Xiongwei; Sun Zheng; Lee Hyoung-gon; Siedlak Sandra L; Perry George; Smith Mark A
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Journal of neurochemistry 2003;86(1):136-42.
2003: Bianco Nicole R; Perry George; Smith Mark A; Templeton Dennis J; Montano Monica M
Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1344-55.
2003: Matsubara Etsuro; Bryant-Thomas Tara; Pacheco Quinto Javier; Henry Tracey L; Poeggeler Burkhard; Herbert Donald; Cruz-Sanchez Felix; Chyan Yau-Jan; Smith Mark A; Perry George; Shoji Mikio; Abe Koji; Leone Anna; Grundke-Ikbal Inge; Wilson Glen L; Ghiso Jorge; Williams Christina; Refolo Lorenzo M; Pappolla Miguel A; Chain Daniel G; Neria Eyal
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.
Journal of neurochemistry 2003;85(5):1101-8.
2003: Tateyama M; Takeda A; Onodera Y; Matsuzaki M; Hasegawa T; Nunomura A; Hirai K; Perry G; Smith M A; Itoyama Y
Oxidative stress and predominant Abeta42(43) deposition in myopathies with rimmed vacuoles.
Acta neuropathologica 2003;105(6):581-5.
2003: Cash Adam D; Aliev Gjumrakch; Siedlak Sandra L; Nunomura Akihiko; Fujioka Hisashi; Zhu Xiongwei; Raina Arun K; Vinters Harry V; Tabaton Massimo; Johnson Anne B; Paula-Barbosa Manuel; Avíla Jesus; Jones Paul K; Castellani Rudy J; Smith Mark A; Perry George
Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.
The American journal of pathology 2003;162(5):1623-7.
2003: Ogawa Osamu; Zhu Xiongwei; Lee Hyoung-Gon; Raina Arun; Obrenovich Mark E; Bowser Robert; Ghanbari Hossein A; Castellani Rudolph J; Perry George; Smith Mark A
Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?
Acta neuropathologica 2003;105(5):524-8.
2003: Ogawa Osamu; Lee Hyoung-gon; Zhu Xiongwei; Raina Arun; Harris Peggy L R; Castellani Rudolph J; Perry George; Smith Mark A
Increased p27, an essential component of cell cycle control, in Alzheimer's disease.
Aging cell 2003;2(2):105-10.
2003: Veurink Gerald; Liu Dan; Taddei Kevin; Perry George; Smith Mark A; Robertson Terry A; Hone Eugene; Groth David M; Atwood Craig S; Martins Ralph N
Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants.
Free radical biology & medicine 2003;34(8):1070-7.
2003: Raina Arun K; Hochman Ayala; Ickes Harold; Zhu Xiongwei; Ogawa Osamu; Cash Adam D; Shimohama Shun; Perry George; Smith Mark A
Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?
Progress in neuro-psychopharmacology & biological psychiatry 2003;27(2):251-4.
2003: Zhu Xiongwei; Ogawa Osamu; Wang Yang; Perry George; Smith Mark A
JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease.
Journal of neurochemistry 2003;85(1):87-93.
2003: Dong Jian; Atwood Craig S; Anderson Vernon E; Siedlak Sandra L; Smith Mark A; Perry George; Carey Paul R
Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence.
Biochemistry 2003;42(10):2768-73.
2003: Smith Mark A; Perry George; Atwood Craig S; Bowen Richard L
Estrogen replacement and risk of Alzheimer disease.
JAMA : the journal of the American Medical Association 2003;289(9):1100; author reply 1101-2.
2003: Gómez-Ramos Alberto; Díaz-Nido Javier; Smith Mark A; Perry George; Avila Jesús
Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells.
Journal of neuroscience research 2003;71(6):863-70.
2003: Perry George; Taddeo Marta A; Petersen Robert B; Castellani Rudy J; Harris Peggy L R; Siedlak Sandra L; Cash Adam D; Liu Quan; Nunomura Akohiko; Atwood Craig S; Smith Mark A
Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2003;16(1):77-81.
2003: Atwood Craig S; Perry George; Smith Mark A
Cerebral hemorrhage and amyloid-beta.
Science (New York, N.Y.) 2003;299(5609):1014; author reply 1014.
2003: Takata Kazuyuki; Kitamura Yoshihisa; Kakimura Jun-ichi; Shibagaki Keiichi; Tsuchiya Daiju; Taniguchi Takashi; Smith Mark A; Perry George; Shimohama Shun
Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis.
Biochemical and biophysical research communications 2003;301(3):699-703.
2003: Raina Arun K; Zhu Xiongwei; Shimohama Shun; Perry George; Smith Mark A
Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept.
Cell biochemistry and biophysics 2003;39(3):249-55.
2003: Aliev Gjumrakch; Smith Mark A; Obrenovich Mark E; de la Torre Jack C; Perry George
Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease.
Neurotoxicity research 2003;5(7):491-504.
2003: Zhu Xiongwei; Perry George; Smith Mark A
Amyotrophic lateral sclerosis: a novel hypothesis involving a gained 'loss of function' in the JNK/SAPK pathway.
Redox report : communications in free radical research 2003;8(3):129-33.
2002: Perry George; Taddeo Marta A; Nunomura Akihiko; Zhu Xiongwei; Zenteno-Savin Tania; Drew Kelly L; Shimohama Shun; Avila Jesús; Castellani Rudolph J; Smith Mark A
Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2002;133(4):507-13.
2002: Drew K L; Tøien Ø; Rivera P M; Smith M A; Perry George; Rice M E
Role of the antioxidant ascorbate in hibernation and warming from hibernation.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2002;133(4):483-92.
2002: Perry George; Nunomura Akihiko; Hirai Keisuke; Zhu Xiongwei; Pérez Mar; Avila Jesús; Castellani Rudolph J; Atwood Craig S; Aliev Gjumrakch; Sayre Lawrence M; Takeda Atsushi; Smith Mark A
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?
Free radical biology & medicine 2002;33(11):1475-9.
2002: Takata K; Kitamura Y; Kakimura J; Shibagaki K; Taniguchi T; Gebicke-Haerter P J; Smith M A; Perry G; Shimohama S
Possible protective mechanisms of heme oxygenase-1 in the brain.
Annals of the New York Academy of Sciences 2002;977():501-6.
2002: Kakimura J; Kitamura Y; Takata K; Tsuchiya D; Taniguchi T; Gebicke-Haerter P J; Smith M A; Perry G; Shimohama S
Possible involvement of ER chaperone Grp78 on reduced formation of amyloid-beta deposits.
Annals of the New York Academy of Sciences 2002;977():327-32.
2002: Obrenovich Mark E; Joseph James A; Atwood Craig S; Perry George; Smith Mark A
Amyloid-beta: a (life) preserver for the brain.
Neurobiology of aging 2002;23(6):1097-9.
2002: Nunomura Akihiko; Chiba Shigeru; Kosaka Kenji; Takeda Atsushi; Castellani Rudy J; Smith Mark A; Perry George
Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies.
Neuroreport 2002;13(16):2035-9.
2002: Smith Mark A; Casadesus Gemma; Joseph James A; Perry George
Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain.
Free radical biology & medicine 2002;33(9):1194-9.
2002: Bowen Richard L; Smith Mark A; Harris Peggy L R; Kubat Zvezdana; Martins Ralph N; Castellani Rudolph J; Perry George; Atwood Craig S
Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology.
Journal of neuroscience research 2002;70(3):514-8.
2002: Castellani Rudy; Hirai Keisuke; Aliev Gjumrakch; Drew Kelly L; Nunomura Akihiko; Takeda Atsushi; Cash Adam D; Obrenovich Mark E; Perry George; Smith Mark A
Role of mitochondrial dysfunction in Alzheimer's disease.
Journal of neuroscience research 2002;70(3):357-60.
2002: Atwood Craig S; Bishop Glenda M; Perry George; Smith Mark A
Amyloid-beta: a vascular sealant that protects against hemorrhage?
Journal of neuroscience research 2002;70(3):356.
2002: Ogawa Osamu; Zhu Xiongwei; Perry George; Smith Mark A
Mitochondrial abnormalities and oxidative imbalance in neurodegenerative disease.
Science of aging knowledge environment : SAGE KE 2002;2002(41):pe16.
2002: Cash Adam D; Perry George; Ogawa Osamu; Raina Arun K; Zhu Xiongwei; Smith Mark A
Is Alzheimer's disease a mitochondrial disorder?
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2002;8(5):489-96.
2002: Lee Hyoung-gon; Zhu Xiongwei; Ghanbari Hossein A; Ogawa Osamu; Raina Arun K; O'Neill Micheal J; Perry George; Smith Mark A
Differential regulation of glutamate receptors in Alzheimer's disease.
Neuro-Signals 2002;11(5):282-92.
2002: Zhu Xiongwei; Lee Hyoung-gon; Raina Arun K; Perry George; Smith Mark A
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Neuro-Signals 2002;11(5):270-81.
2002: Hartzler Anthony W; Zhu Xiongwei; Siedlak Sandra L; Castellani Rudolph J; Avilá Jesus; Perry George; Smith Mark A
The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.
Neurobiology of aging 2002;23(5):855-9.
2002: Zhou Fang; Braddock Joan F; Hu Yong; Zhu Xiongwei; Castellani Rudy J; Smith Mark A; Drew Kelly L
Microbial origin of glutamate, hibernation and tissue trauma: an in vivo microdialysis study.
Journal of neuroscience methods 2002;119(2):121-8.
2002: Cash A D; Perry G; Smith M A
Therapeutic potential in Alzheimer disease.
Current medicinal chemistry 2002;9(17):1605-10.
2002: Tamagno Elena; Bardini Paola; Obbili Alessandra; Vitali Antonella; Borghi Roberta; Zaccheo Damiano; Pronzato Maria A; Danni Oliviero; Smith Mark A; Perry George; Tabaton Massimo
Oxidative stress increases expression and activity of BACE in NT2 neurons.
Neurobiology of disease 2002;10(3):279-88.
2002: Shi Jiong; Perry George; Berridge Marc S; Aliev Gjumrakch; Siedlak Sandy L; Smith Mark A; LaManna Joseph C; Friedland Robert P
Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(8):1044-51.
2002: Smith Mark A; Atwood Craig S; Joseph James A; Perry George
Ill-fated amyloid-beta vaccine.
Journal of neuroscience research 2002;69(3):285.
2002: Atwood Craig S; Martins Ralph N; Smith Mark A; Perry George
Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins.
Peptides 2002;23(7):1343-50.
2002: Rottkamp Catherine A; Atwood Craig S; Joseph James A; Nunomura Akihiko; Perry George; Smith Mark A
The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease.
Peptides 2002;23(7):1333-41.
2002: Pappolla Miguel A; Smith Mark A; Bryant-Thomas Tara; Bazan Nicolas; Petanceska Suzana; Perry George; Thal Leon J; Sano Mary; Refolo Lorenzo M
Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis.
Free radical biology & medicine 2002;33(2):173-81.
2002: Smith Mark A; Joseph James A; Atwood Craig S; Perry George
Dangers of the amyloid-beta vaccination.
Acta neuropathologica 2002;104(1):110.
2002: Bowser Robert; Smith Mark A
Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle.
Journal of Alzheimer's disease : JAD 2002;4(3):249-54.
2002: Atwood C S; Robinson S R; Smith M A
Amyloid-beta: redox-metal chelator and antioxidant.
Journal of Alzheimer's disease : JAD 2002;4(3):203-14.
2002: Prat María I; Adamo Ana M; González Silvia A; Affranchino José L; Ikeda Masaki; Matsubara Etsuro; Shoji Mikio; Smith Mark A; Castaño Eduardo M; Morelli Laura
Presenilin 1 overexpressions in Chinese hamster ovary (CHO) cells decreases the phosphorylation of retinoblastoma protein: relevance for neurodegeneration.
Neuroscience letters 2002;326(1):9-12.
2002: Smith Mark A; Perry George; Pryor William A
Causes and consequences of oxidative stress in Alzheimer's disease.
Free radical biology & medicine 2002;32(11):1049.
2002: Smith Mark A; Atwood Craig S; Joseph James A; Perry George
Predicting the failure of amyloid-beta vaccine.
Lancet 2002;359(9320):1864-5.
2002: Smith Mark A; Drew Kelly L; Nunomura Akihiko; Takeda Atsushi; Hirai Keisuke; Zhu Xiongwei; Atwood Craig S; Raina Arun K; Rottkamp Catherine A; Sayre Lawrence M; Friedland Robert P; Perry George
Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?
Neurochemistry international 2002;40(6):527-31.
2002: Pappolla Miguel A; Simovich Marcia J; Bryant-Thomas Tara; Chyan Yau-Jan; Poeggeler Burkhard; Dubocovich Margarita; Bick Roger; Perry George; Cruz-Sanchez Felix; Smith Mark A
The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors.
Journal of pineal research 2002;32(3):135-42.
2002: Bishop Glenda M; Robinson Stephen R; Smith Mark A; Perry George; Atwood Craig S
Call for Elan to publish Alzheimer's trial details.
Nature 2002;416(6882):677.
2002: Guentchev Marin; Siedlak Sandra L; Jarius Christa; Tagliavini Fabrizio; Castellani Rudy J; Perry George; Smith Mark A; Budka Herbert
Oxidative damage to nucleic acids in human prion disease.
Neurobiology of disease 2002;9(3):275-81.
2002: Kakimura Jun-Ichi; Kitamura Yoshihisa; Takata Kazuyuki; Umeki Masaaki; Suzuki Sanae; Shibagaki Keiichi; Taniguchi Takashi; Nomura Yasuyuki; Gebicke-Haerter Peter J; Smith Mark A; Perry George; Shimohama Shun
Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(6):601-3.
2002: Du Yunpeng; Smith Mark A; Miller Casey M; Kern T S
Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine.
Journal of neurochemistry 2002;80(5):771-9.
2002: Kikuchi Akio; Takeda Atsushi; Onodera Hiroshi; Kimpara Teiko; Hisanaga Kinya; Sato Nobuyuki; Nunomura Akihiko; Castellani Rudy J; Perry George; Smith Mark A; Itoyama Yasuto
Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy.
Neurobiology of disease 2002;9(2):244-8.
2002: Ogawa Osamu; Perry George; Smith Mark A
The "Down's" side of mitochondria.
Developmental cell 2002;2(3):255-6.
2002: Pérez Mar; Hernández Félix; Gómez-Ramos Alberto; Smith Mark; Perry George; Avila Jesús
Formation of aberrant phosphotau fibrillar polymers in neural cultured cells.
European journal of biochemistry / FEBS 2002;269(5):1484-9.
2002: Clapp-Lilly Kimberly L; Smith Mark A; Perry George; Harris Peggy L; Zhu Xiongwei; Drew Kelly L; Duffy Lawrence K
Melatonin exhibits antioxidant properties in a mouse brain slice model of excitotoxicity.
International journal of circumpolar health 2002;61(1):32-40.
2002: Borghi R; Giliberto L; Assini A; Delacourte A; Perry G; Smith M A; Strocchi P; Zaccheo D; Tabaton M
Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy.
Neurology 2002;58(4):589-92.
2002: Castellani Rudy J; Perry George; Siedlak Sandra L; Nunomura Akihiko; Shimohama Shun; Zhang Jing; Montine Thomas; Sayre Lawrence M; Smith Mark A
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans.
Neuroscience letters 2002;319(1):25-8.
2002: Wataya Takafumi; Nunomura Akihiko; Smith Mark A; Siedlak Sandra L; Harris Peggy L R; Shimohama Shun; Szweda Luke I; Kaminski Matthew A; Avila Jesus; Price Donald L; Cleveland Don W; Sayre Lawrence M; Perry George
High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal.
The Journal of biological chemistry 2002;277(7):4644-8.
2002: Zhang J; Montine T J; Smith M A; Siedlak S L; Gu G; Robertson D; Perry G
The mitochondrial common deletion in Parkinson's disease and related movement disorders.
Parkinsonism & related disorders 2002;8(3):165-70.
2002: Aliev G; Smith M A; Seyidova D; Neal M L; Shi J; Loizidou M; Turmaine M; Friedland R P; Taylor I; Burnstock G; Perry G; Lamanna J C
Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium.
Journal of submicroscopic cytology and pathology 2002;34(1):37-50.
2002: Aliev Gjumrakch; Smith Mark A; Seyidov Dilara; Neal Maxwell Lewis; Lamb Bruce T; Nunomura Akihiko; Gasimov Eldar K; Vinters Harry V; Perry George; LaManna Joseph C; Friedland Robert P
The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease.
Brain pathology (Zurich, Switzerland) 2002;12(1):21-35.
2002: Smith Mark A; Turner Monica G; Rusch Donald H
The effect of military training activity on eastern lupine and the Karner blue butterfly at Fort McCoy, Wisconsin, USA.
Environmental management 2002;29(1):102-15.
2002: Perry G; Nunomura A; Cash A D; Taddeo M A; Hirai K; Aliev G; Avila J; Wataya T; Shimohama S; Atwood C S; Smith M A
Reactive oxygen: its sources and significance in Alzheimer disease.
Journal of neural transmission. Supplementum 2002;(62):69-75.
2002: Bishop Glenda M; Robinson Stephen R; Liu Quan; Perry George; Atwood Craig S; Smith Mark A
Iron: a pathological mediator of Alzheimer disease?
Developmental neuroscience 2002;24(2-3):184-7.
2002: Perry George; Sayre Lawrence M; Atwood Craig S; Castellani Rudolph J; Cash Adam D; Rottkamp Catherine A; Smith Mark A
The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications.
CNS drugs 2002;16(5):339-52.
2001: Bierhaus A; Schiekofer S; Schwaninger M; Andrassy M; Humpert P M; Chen J; Hong M; Luther T; Henle T; Klöting I; Morcos M; Hofmann M; Tritschler H; Weigle B; Kasper M; Smith M; Perry G; Schmidt A M; Stern D M; Häring H U; Schleicher E; Nawroth P P
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Diabetes 2001;50(12):2792-808.
2001: Zhu X; Castellani R J; Takeda A; Nunomura A; Atwood C S; Perry G; Smith M A
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Mechanisms of ageing and development 2001;123(1):39-46.
2001: Raina A K; Pardo P; Rottkamp C A; Zhu X; Pereira-Smith O M; Smith M A
Neurons in Alzheimer disease emerge from senescence.
Mechanisms of ageing and development 2001;123(1):3-9.
2001: Zhu X; Rottkamp C A; Hartzler A; Sun Z; Takeda A; Boux H; Shimohama S; Perry G; Smith M A
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.
Journal of neurochemistry 2001;79(2):311-8.
2001: Drew K L; Rice M E; Kuhn T B; Smith M A
Neuroprotective adaptations in hibernation: therapeutic implications for ischemia-reperfusion, traumatic brain injury and neurodegenerative diseases.
Free radical biology & medicine 2001;31(5):563-73.
2001: Aliev G; Smith M A; Turmaine M; Neal M L; Zimina T V; Friedland R P; Perry G; LaManna J C; Burnstock G
Atherosclerotic lesions are associated with increased immunoreactivity for inducible nitric oxide synthase and endothelin-1 in thoracic aortic intimal cells of hyperlipidemic Watanabe rabbits.
Experimental and molecular pathology 2001;71(1):40-54.
2001: Nunomura A; Perry G; Aliev G; Hirai K; Takeda A; Balraj E K; Jones P K; Ghanbari H; Wataya T; Shimohama S; Chiba S; Atwood C S; Petersen R B; Smith M A
Oxidative damage is the earliest event in Alzheimer disease.
Journal of neuropathology and experimental neurology 2001;60(8):759-67.
2001: Castellani R J; Harris P L; Sayre L M; Fujii J; Taniguchi N; Vitek M P; Founds H; Atwood C S; Perry G; Smith M A
Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine.
Free radical biology & medicine 2001;31(2):175-80.
2001: Pappolla M A; Omar R A; Chyan Y J; Ghiso J; Hsiao K; Bozner P; Perry G; Smith M A; Cruz-Sanchez F
Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".
Journal of neurochemistry 2001;78(1):121-8.
2001: Zhou F; Zhu X; Castellani R J; Stimmelmayr R; Perry G; Smith M A; Drew K L
Hibernation, a model of neuroprotection.
The American journal of pathology 2001;158(6):2145-51.
2001: Sayre L M; Smith M A; Perry G
Chemistry and biochemistry of oxidative stress in neurodegenerative disease.
Current medicinal chemistry 2001;8(7):721-38.
2001: Campbell A; Smith M A; Sayre L M; Bondy S C; Perry G
Mechanisms by which metals promote events connected to neurodegenerative diseases.
Brain research bulletin 2001;55(2):125-32.
2001: Clapp-Lilly K L; Smith M A; Perry G; Harris P L; Zhu X; Duffy L K
Melatonin acts as antioxidant and pro-oxidant in an organotypic slice culture model of Alzheimer's disease.
Neuroreport 2001;12(6):1277-80.
2001: Hirai K; Aliev G; Nunomura A; Fujioka H; Russell R L; Atwood C S; Johnson A B; Kress Y; Vinters H V; Tabaton M; Shimohama S; Cash A D; Siedlak S L; Harris P L; Jones P K; Petersen R B; Perry G; Smith M A
Mitochondrial abnormalities in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(9):3017-23.
2001: Raina A K; Hochman A; Zhu X; Rottkamp C A; Nunomura A; Siedlak S L; Boux H; Castellani R J; Perry G; Smith M A
Abortive apoptosis in Alzheimer's disease.
Acta neuropathologica 2001;101(4):305-10.
2001: Wong B S; Liu T; Paisley D; Li R; Pan T; Chen S G; Perry G; Petersen R B; Smith M A; Melton D W; Gambetti P; Brown D R; Sy M S
Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function.
Molecular and cellular neurosciences 2001;17(4):768-75.
2001: Alicigüzel Y; Ozdem S N; Ozdem S S; Karayalçin U; Siedlak S L; Perry G; Smith M A
Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients.
Free radical biology & medicine 2001;30(6):665-70.
2001: Clapp-Lilly K L; Smith M A; Perry G; Duffy L K
Melatonin reduces interleukin secretion in amyloid-beta stressed mouse brain slices.
Chemico-biological interactions 2001;134(1):101-7.
2001: Rottkamp C A; Raina A K; Zhu X; Gaier E; Bush A I; Atwood C S; Chevion M; Perry G; Smith M A
Redox-active iron mediates amyloid-beta toxicity.
Free radical biology & medicine 2001;30(4):447-50.
2001: Aliev G; Seyidov D; Neal M L; Shi J; Vigan T; Hernandez A; Folco G; Soas A H; Zimina T V; Smith M A; Perry G; Lamanna J C; Friedland R P
The effect of agonists and antagonists on the morphology of non-transformed human smooth muscle cell in vitro.
Journal of submicroscopic cytology and pathology 2001;33(1-2):141-9.
2001: Perry G; Avila J; Espey M G; Wink D A; Atwood C S; Smith M A
Biochemistry of neurodegeneration.
Science (New York, N.Y.) 2001;291(5504):595-7.
2001: Wong B S; Liu T; Li R; Pan T; Petersen R B; Smith M A; Gambetti P; Perry G; Manson J C; Brown D R; Sy M S
Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein.
Journal of neurochemistry 2001;76(2):565-72.
2001: Zhu X; Raina A K; Rottkamp C A; Aliev G; Perry G; Boux H; Smith M A
Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.
Journal of neurochemistry 2001;76(2):435-41.
2001: Joseph J; Shukitt-Hale B; Denisova N A; Martin A; Perry G; Smith M A
Copernicus revisited: amyloid beta in Alzheimer's disease.
Neurobiology of aging 2001;22(1):131-46.
2001: Perry G; Zhu X; Smith M A
Do neurons have a choice in death?
The American journal of pathology 2001;158(1):1-2.
2001: Alicigüzel Y; Ozdem S; Demir A Y; Unal F; Kumbul D; Ozdem S S; Perry G; Smith M A
Effect of the herbicide 4-CPA on human erythrocyte antioxidant enzymes in vitro.
Redox report : communications in free radical research 2001;6(3):153-4.
2000: Pérez M; Cuadros R; Smith M A; Perry G; Avila J
Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal.
FEBS letters 2000;486(3):270-4.
2000: Harris P L; Zhu X; Pamies C; Rottkamp C A; Ghanbari H A; McShea A; Feng Y; Ferris D K; Smith M A
Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes.
Neurobiology of aging 2000;21(6):837-41.
2000: Zhu X; Rottkamp C A; Raina A K; Brewer G J; Ghanbari H A; Boux H; Smith M A
Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease.
Neurobiology of aging 2000;21(6):807-13.
2000: Nunomura A; Perry G; Pappolla M A; Friedland R P; Hirai K; Chiba S; Smith M A
Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome.
Journal of neuropathology and experimental neurology 2000;59(11):1011-7.
2000: Mah A L; Perry G; Smith M A; Monteiro M J
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.
The Journal of cell biology 2000;151(4):847-62.
2000: Zhu X; Rottkamp C A; Boux H; Takeda A; Perry G; Smith M A
Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease.
Journal of neuropathology and experimental neurology 2000;59(10):880-8.
2000: Takeda A; Smith M A; Avilá J; Nunomura A; Siedlak S L; Zhu X; Perry G; Sayre L M
In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.
Journal of neurochemistry 2000;75(3):1234-41.
2000: Castellani R J; Siedlak S L; Perry G; Smith M A
Sequestration of iron by Lewy bodies in Parkinson's disease.
Acta neuropathologica 2000;100(2):111-4.
2000: Rottkamp C A; Nunomura A; Hirai K; Sayre L M; Perry G; Smith M A
Will antioxidants fulfill their expectations for the treatment of Alzheimer disease?
Mechanisms of ageing and development 2000;116(2-3):169-79.
2000: Smith M A; Rottkamp C A; Nunomura A; Raina A K; Perry G
Oxidative stress in Alzheimer's disease.
Biochimica et biophysica acta 2000;1502(1):139-44.
2000: Raina A K; Zhu X; Rottkamp C A; Monteiro M; Takeda A; Smith M A
Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease.
Journal of neuroscience research 2000;61(2):128-33.
2000: Zhu X; Raina A K; Boux H; Simmons Z L; Takeda A; Smith M A
Activation of oncogenic pathways in degenerating neurons in Alzheimer disease.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2000;18(4-5):433-7.
2000: Perry G; Nunomura A; Hirai K; Takeda A; Aliev G; Smith M A
Oxidative damage in Alzheimer's disease: the metabolic dimension.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2000;18(4-5):417-21.
2000: Sayre L M; Perry G; Atwood C S; Smith M A
The role of metals in neurodegenerative diseases.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(4):731-41.
2000: Shimohama S; Tanino H; Kawakami N; Okamura N; Kodama H; Yamaguchi T; Hayakawa T; Nunomura A; Chiba S; Perry G; Smith M A; Fujimoto S
Activation of NADPH oxidase in Alzheimer's disease brains.
Biochemical and biophysical research communications 2000;273(1):5-9.
2000: Cuajungco M P; Goldstein L E; Nunomura A; Smith M A; Lim J T; Atwood C S; Huang X; Farrag Y W; Perry G; Bush A I
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc.
The Journal of biological chemistry 2000;275(26):19439-42.
2000: Odetti P; Garibaldi S; Norese R; Angelini G; Marinelli L; Valentini S; Menini S; Traverso N; Zaccheo D; Siedlak S; Perry G; Smith M A; Tabaton M
Lipoperoxidation is selectively involved in progressive supranuclear palsy.
Journal of neuropathology and experimental neurology 2000;59(5):393-7.
2000: Perry G; Smith M A
Promises and pitfalls of therapeutics to modify oxidant balance in chronic disease.
IDrugs : the investigational drugs journal 2000;3(4):371-2.
2000: Friedland R P; Shi J; Lamanna J C; Smith M A; Perry G
Prospects for noninvasive imaging of brain amyloid beta in Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;903():123-8.
2000: Shi J; Perry G; Smith M A; Friedland R P
Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease.
Neurobiology of aging 2000;21(2):357-61.
2000: Perry G; Raina A K; Nunomura A; Wataya T; Sayre L M; Smith M A
How important is oxidative damage? Lessons from Alzheimer's disease.
Free radical biology & medicine 2000;28(5):831-4.
2000: Gerst J L; Raina A K; Pirim I; McShea A; Harris P L; Siedlak S L; Takeda A; Petersen R B; Smith M A
Altered cell-matrix associated ADAM proteins in Alzheimer disease.
Journal of neuroscience research 2000;59(5):680-4.
2000: Raina A K; Perry G; Nunomura A; Sayre L M; Smith M A
Histochemical and immunocytochemical approaches to the study of oxidative stress.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2000;38(2):93-7.
2000: Perry G; Nunomura A; Raina A K; Smith M A
Amyloid-beta junkies.
Lancet 2000;355(9205):757.
2000: Takeda A; Perry G; Abraham N G; Dwyer B E; Kutty R K; Laitinen J T; Petersen R B; Smith M A
Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau.
The Journal of biological chemistry 2000;275(8):5395-9.
2000: Sayre L M; Perry G; Harris P L; Liu Y; Schubert K A; Smith M A
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals.
Journal of neurochemistry 2000;74(1):270-9.
2000: de Carvalho C V; Payão S L; Smith M A
DNA methylation, ageing and ribosomal genes activity.
Biogerontology 2000;1(4):357-61.
2000: Castellani R J; Harris P L; Lecroisey A; Izadi-Pruneyre N; Wandersman C; Perry G; Smith M A
Evidence for a novel heme-binding protein, HasAh, in Alzheimer disease.
Antioxidants & redox signaling 2000;2(1):137-42.
2000: Kim H T; Russell R L; Raina A K; Harris P L; Siedlak S L; Zhu X; Petersen R B; Shimohama S; Smith M A; Perry G
Protein disulfide isomerase in Alzheimer disease.
Antioxidants & redox signaling 2000;2(3):485-9.
2000: Smith M A; Nunomura A; Zhu X; Takeda A; Perry G
Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease.
Antioxidants & redox signaling 2000;2(3):413-20.
2000: Smith M A; Joseph J A; Perry G
Arson. Tracking the culprit in Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;924():35-8.
2000: Rottkamp C A; Nunomura A; Raina A K; Sayre L M; Perry G; Smith M A
Oxidative stress, antioxidants, and Alzheimer disease.
Alzheimer disease and associated disorders 2000;14 Suppl 1():S62-6.
2000: Raina A K; Zhu X; Monteiro M; Takeda A; Smith M A
Abortive oncogeny and cell cycle-mediated events in Alzheimer disease.
Progress in cell cycle research 2000;4():235-42.
1999: Capellari S; Zaidi S I; Urig C B; Perry G; Smith M A; Petersen R B
Prion protein glycosylation is sensitive to redox change.
The Journal of biological chemistry 1999;274(49):34846-50.
1999: Smith M A; Petot G J; Perry G
Diet and oxidative stress: a novel synthesis of epidemiological data on Alzheimer's disease.
Journal of Alzheimer's disease : JAD 1999;1(4-5):203-6.
1999: Aliev G; Ragazzi E; Smith M A; Mironov A; Perry G
Morphological features of regeneration of rabbit aortic endothelium after cryoinduced vascular damage.
Journal of submicroscopic cytology and pathology 1999;31(4):495-502.
1999: Castellani R J; Perry G; Brenner D S; Smith M A
Alexander disease: Alzheimer disease of the developing brain?
Alzheimer disease and associated disorders 1999;13(4):232-5.
1999: Shi J; Perry G; Aliev G; Smith M A; Ashe K H; Friedland R P
Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model.
Neuroreport 1999;10(15):3229-32.
1999: Russell R L; Siedlak S L; Raina A K; Bautista J M; Smith M A; Perry G
Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease.
Archives of biochemistry and biophysics 1999;370(2):236-9.
1999: Raina A K; Takeda A; Smith M A
Mitotic neurons: a dogma succumbs.
Experimental neurology 1999;159(1):248-9.
1999: Barlow C; Dennery P A; Shigenaga M K; Smith M A; Morrow J D; Roberts L J; Wynshaw-Boris A; Levine R L
Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9915-9.
1999: Perry G; Roder H; Nunomura A; Takeda A; Friedlich A L; Zhu X; Raina A K; Holbrook N; Siedlak S L; Harris P L; Smith M A
Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.
Neuroreport 1999;10(11):2411-5.
1999: Zhu X; Raina A K; Smith M A
Cell cycle events in neurons. Proliferation or death?
The American journal of pathology 1999;155(2):327-9.
1999: Smith M A; Nunomura A; Takeda A; Perry G
Asking the right questions.
Science (New York, N.Y.) 1999;285(5428):665.
1999: McShea A; Wahl A F; Smith M A
Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease.
Medical hypotheses 1999;52(6):525-7.
1999: Castellani R J; Smith M A; Nunomura A; Harris P L; Perry G
Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?
Free radical biology & medicine 1999;26(11-12):1508-12.
1999: Zhang J; Perry G; Smith M A; Robertson D; Olson S J; Graham D G; Montine T J
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons.
The American journal of pathology 1999;154(5):1423-9.
1999: Raina A K; Monteiro M J; McShea A; Smith M A
The role of cell cycle-mediated events in Alzheimer's disease.
International journal of experimental pathology 1999;80(2):71-6.
1999: Raina A K; Takeda A; Nunomura A; Perry G; Smith M A
Genetic evidence for oxidative stress in Alzheimer's disease.
Neuroreport 1999;10(6):1355-7.
1999: Sayre L M; Perry G; Smith M A
Redox metals and neurodegenerative disease.
Current opinion in chemical biology 1999;3(2):220-5.
1999: Morgan T E; Xie Z; Goldsmith S; Yoshida T; Lanzrein A S; Stone D; Rozovsky I; Perry G; Smith M A; Finch C E
The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction.
Neuroscience 1999;89(3):687-99.
1999: Nunomura A; Perry G; Pappolla M A; Wade R; Hirai K; Chiba S; Smith M A
RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(6):1959-64.
1999: Perry G; Smith M A
[Is the lesion produced by oxidation a central part in the pathogenesis of Alzheimer's disease?]
Neurología (Barcelona, Spain) 1999;14(2):78-84.
1999: Chen X; Eswaran D; Smith M A; Perry G; Anderson V E
Universal isolation of cross-linked peptides: application to neurofibrillary tangles.
Bioconjugate chemistry 1999;10(1):112-8.
1999: McShea A; Zelasko D A; Gerst J L; Smith M A
Signal transduction abnormalities in Alzheimer's disease: evidence of a pathogenic stimuli.
Brain research 1999;815(2):237-42.
1999: Raina A K; Templeton D J; Deak J C; Perry G; Smith M A
Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease.
Redox report : communications in free radical research 1999;4(1-2):23-7.
1999: Nunomura A; Perry G; Hirai K; Aliev G; Takeda A; Chiba S; Smith M A
Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome.
Annals of the New York Academy of Sciences 1999;893():362-4.
1999: Sayre L M; Perry G; Smith M A
In situ methods for detection and localization of markers of oxidative stress: application in neurodegenerative disorders.
Methods in enzymology 1999;309():133-52.
1999: Gerst J L; Siedlak S L; Nunomura A; Castellani R; Perry G; Smith M A
Role of oxidative stress in frontotemporal dementia.
Dementia and geriatric cognitive disorders 1999;10 Suppl 1():85-7.
1998: Smith M A; Perry G
What are the facts and artifacts of the pathogenesis and etiology of Alzheimer disease?
Journal of chemical neuroanatomy 1998;16(1):35-41.
1998: Velasco M E; Smith M A; Siedlak S L; Nunomura A; Perry G
Striation is the characteristic neuritic abnormality in Alzheimer disease.
Brain research 1998;813(2):329-33.
1998: Perry G; Nunomura A; Lucassen P; Lassmann H; Smith M A
Apoptosis and Alzheimer's disease.
Science (New York, N.Y.) 1998;282(5392):1268-9.
1998: Smith M A; Vasák M; Knipp M; Castellani R J; Perry G
Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease.
Free radical biology & medicine 1998;25(8):898-902.
1998: Hattori N; Kitagawa K; Higashida T; Yagyu K; Shimohama S; Wataya T; Perry G; Smith M A; Inagaki C
CI-ATPase and Na+/K(+)-ATPase activities in Alzheimer's disease brains.
Neuroscience letters 1998;254(3):141-4.
1998: Perry G; Nunomura A; Smith M A
A suicide note from Alzheimer disease neurons?
Nature medicine 1998;4(8):897-8.
1998: Perry G; Smith M A
Is oxidative damage central to the pathogenesis of Alzheimer disease?
Acta neurologica Belgica 1998;98(2):175-9.
1998: Smith M A; Sayre L M; Anderson V E; Harris P L; Beal M F; Kowall N; Perry G
Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(6):731-5.
1998: Smith M A; Hirai K; Hsiao K; Pappolla M A; Harris P L; Siedlak S L; Tabaton M; Perry G
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.
Journal of neurochemistry 1998;70(5):2212-5.
1998: Perry G; Smith M A; McCann C E; Siedlak S L; Jones P K; Friedland R P
Cerebrovascular muscle atrophy is a feature of Alzheimer's disease.
Brain research 1998;791(1-2):63-6.
1998: Pappolla M A; Chyan Y J; Omar R A; Hsiao K; Perry G; Smith M A; Bozner P
Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.
The American journal of pathology 1998;152(4):871-7.
1998: Smith M A; Wehr K; Harris P L; Siedlak S L; Connor J R; Perry G
Abnormal localization of iron regulatory protein in Alzheimer's disease.
Brain research 1998;788(1-2):232-6.
1998: Castellani R J; Perry G; Harris P L; Cohen M L; Sayre L M; Salomon R G; Smith M A
Advanced lipid peroxidation end-products in Alexander's disease.
Brain research 1998;787(1):15-8.
1998: Odetti P; Angelini G; Dapino D; Zaccheo D; Garibaldi S; Dagna-Bricarelli F; Piombo G; Perry G; Smith M; Traverso N; Tabaton M
Early glycoxidation damage in brains from Down's syndrome.
Biochemical and biophysical research communications 1998;243(3):849-51.
1998: Kitamura Y; Shimohama S; Kamoshima W; Ota T; Matsuoka Y; Nomura Y; Smith M A; Perry G; Whitehouse P J; Taniguchi T
Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.
Brain research 1998;780(2):260-9.
1998: Münch G; Schinzel R; Loske C; Wong A; Durany N; Li J J; Vlassara H; Smith M A; Perry G; Riederer P
Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts.
Journal of neural transmission (Vienna, Austria : 1996) 1998;105(4-5):439-61.
1998: Smith M A
Alzheimer disease.
International review of neurobiology 1998;42():1-54.
1997: Smith M A; Harris P L; Sayre L M; Perry G
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9866-8.
1997: Smith M A; Nagaraj R H; Perry G
Protocol for quantitative analysis of paired helical filament solubilization: a method applicable to insoluble amyloids and inclusion bodies.
Brain research. Brain research protocols 1997;1(3):247-52.
1997: Castellani R J; Perry G; Harris P L; Monnier V M; Cohen M L; Smith M A
Advanced glycation modification of Rosenthal fibers in patients with Alexander disease.
Neuroscience letters 1997;231(2):79-82.
1997: McShea A; Harris P L; Webster K R; Wahl A F; Smith M A
Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.
The American journal of pathology 1997;150(6):1933-9.
1997: Salomon R G; Subbanagounder G; O'Neil J; Kaur K; Smith M A; Hoff H F; Perry G; Monnier V M
Levuglandin E2-protein adducts in human plasma and vasculature.
Chemical research in toxicology 1997;10(5):536-45.
1997: Sayre L M; Zelasko D A; Harris P L; Perry G; Salomon R G; Smith M A
4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease.
Journal of neurochemistry 1997;68(5):2092-7.
1997: Smith M A; Richey Harris P L; Sayre L M; Beckman J S; Perry G
Widespread peroxynitrite-mediated damage in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(8):2653-7.
1997: Tabaton M; Perry G; Smith M; Vitek M; Angelini G; Dapino D; Garibaldi S; Zaccheo D; Odetti P
Is amyloid beta-protein glycated in Alzheimer's disease?
Neuroreport 1997;8(4):907-9.
1997: Smith M A; Perry G
The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis.
Journal of neuropathology and experimental neurology 1997;56(2):217.
1996: Castellani R; Smith M A; Richey P L; Perry G
Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease.
Brain research 1996;737(1-2):195-200.
1996: Smith M A; Tabaton M; Perry G
Early contribution of oxidative glycation in Alzheimer disease.
Neuroscience letters 1996;217(2-3):210-1.
1996: Smith M A; Perry G; Richey P L; Sayre L M; Anderson V E; Beal M F; Kowall N
Oxidative damage in Alzheimer's.
Nature 1996;382(6587):120-1.
1996: Smith M A; Sayre L M; Monnier V M; Perry G
Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1996;28(1-3):41-8.
1996: Smith M A; Siedlak S L; Richey P L; Nagaraj R H; Elhammer A; Perry G
Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease.
Brain research 1996;717(1-2):99-108.
1996: Smith M A; Dunbar C E; Miller E J; Perry G
Trypsin interaction with the senile plaques of Alzheimer disease is mediated by beta-protein precursor.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1996;27(2):145-54.
1996: Smith M A; Sayre L M; Perry G
Diabetes mellitus and Alzheimer's disease: glycation as a biochemical link.
Diabetologia 1996;39(2):247.
1996: Smith M A; Perry G
Alzheimer disease: protein-protein interaction and oxidative stress.
Boletín de estudios médicos y biológicos 1996;44(1-4):5-10.
1996: Giaccone G; Pedrotti B; Migheli A; Verga L; Perez J; Racagni G; Smith M A; Perry G; De Gioia L; Selvaggini C; Salmona M; Ghiso J; Frangione B; Islam K; Bugiani O; Tagliavini F
beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease.
The American journal of pathology 1996;148(1):79-87.
1996: Praprotnik D; Smith M A; Richey P L; Vinters H V; Perry G
Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease.
Acta neuropathologica 1996;91(3):226-35.
1996: Praprotnik D; Smith M A; Richey P L; Vinters H V; Perry G
Plasma membrane fragility in dystrophic neurites in senile plaques of Alzheimer's disease: an index of oxidative stress.
Acta neuropathologica 1996;91(1):1-5.
1995: Smith M A; Perry G
Free radical damage, iron, and Alzheimer's disease.
Journal of the neurological sciences 1995;134 Suppl():92-4.
1995: Akbarian S; Smith M A; Jones E G
Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia.
Brain research 1995;699(2):297-304.
1995: Castellani R; Smith M A; Richey P L; Kalaria R; Gambetti P; Perry G
Evidence for oxidative stress in Pick disease and corticobasal degeneration.
Brain research 1995;696(1-2):268-71.
1995: Premkumar D R; Smith M A; Richey P L; Petersen R B; Castellani R; Kutty R K; Wiggert B; Perry G; Kalaria R N
Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease.
Journal of neurochemistry 1995;65(3):1399-402.
1995: Smith M A; Monnier V M; Sayre L M; Perry G
Amyloidosis, advanced glycation end products and Alzheimer disease.
Neuroreport 1995;6(12):1595-6.
1995: Yan S D; Yan S F; Chen X; Fu J; Chen M; Kuppusamy P; Smith M A; Perry G; Godman G C; Nawroth P
Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.
Nature medicine 1995;1(7):693-9.
1995: Smith M A; Rudnicka-Nawrot M; Richey P L; Praprotnik D; Mulvihill P; Miller C A; Sayre L M; Perry G
Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease.
Journal of neurochemistry 1995;64(6):2660-6.
1995: Smith M A; Sayre L M; Monnier V M; Perry G
Radical AGEing in Alzheimer's disease.
Trends in neurosciences 1995;18(4):172-6.
1995: Smith M A; Siedlak S L; Richey P L; Mulvihill P; Ghiso J; Frangione B; Tagliavini F; Giaccone G; Bugiani O; Praprotnik D
Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease.
Nature medicine 1995;1(4):365-9.
1995: Smith M A; Sayre L M; Vitek M P; Monnier V M; Perry G
Early AGEing and Alzheimer's.
Nature 1995;374(6520):316.
1995: Richey P L; Siedlak S L; Smith M A; Perry G
Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis.
Biochemical and biophysical research communications 1995;208(2):657-63.
1995: Smith M A; Richey P L; Kutty R K; Wiggert B; Perry G
Ultrastructural localization of heme oxygenase-1 to the neurofibrillary pathology of Alzheimer disease.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1995;24(2-3):227-30.
1995: Cras P; Smith M A; Richey P L; Siedlak S L; Mulvihill P; Perry G
Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease.
Acta neuropathologica 1995;89(4):291-5.
1994: Smith M A; Richey P L; Taneda S; Kutty R K; Sayre L M; Monnier V M; Perry G
Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease.
Annals of the New York Academy of Sciences 1994;738():447-54.
1994: Yan S D; Chen X; Schmidt A M; Brett J; Godman G; Zou Y S; Scott C W; Caputo C; Frappier T; Smith M A
Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7787-91.
1994: Smith M A; Kutty R K; Richey P L; Yan S D; Stern D; Chader G J; Wiggert B; Petersen R B; Perry G
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.
The American journal of pathology 1994;145(1):42-7.
1994: Smith M A; Taneda S; Richey P L; Miyata S; Yan S D; Stern D; Sayre L M; Monnier V M; Perry G
Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5710-4.
1994: Smith M A; Perry G
Alzheimer disease: an imbalance of proteolytic regulation?
Medical hypotheses 1994;42(4):277-9.
1993: Perry G; Richey P L; Siedlak S L; Smith M A; Mulvihill P; DeWitt D A; Barnett J; Greenberg B D; Kalaria R N
Immunocytochemical evidence that the beta-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease.
The American journal of pathology 1993;143(6):1586-93.
1993: Smith M A; Kalaria R N; Perry G
Alpha 1-trypsin immunoreactivity in Alzheimer disease.
Biochemical and biophysical research communications 1993;193(2):579-84.
1989: Landon M; Smith M A; Clarke K; Kidd M
Immunoaffinity chromatographic purification of amyloid-related proteins from Alzheimer's disease brain tissue.
Progress in clinical and biological research 1989;317():903-12.

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