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Xiongwei Zhu

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Chen Yao; Jinwei Zhang; Xiongwei Zhu; Dario R Alessi; Maria Deak; Yue Gao; William M Johnson; John J Mieyal; Hanno Roder; Wen Wang; Amy L Wilson-Delfosse; Shu G Chen
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.
George Perry; Mark A Smith; Aaron A Sorensen; Xiongwei Zhu; Jesús Avila
Preface. Alzheimer's disease: advances for a new century.
Xiongwei Zhu; George Perry; Mark A Smith; Xinglong Wang
Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease.

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2013: Chen Yao; Jinwei Zhang; Xiongwei Zhu; Dario R Alessi; Maria Deak; Yue Gao; William M Johnson; John J Mieyal; Hanno Roder; Wen Wang; Amy L Wilson-Delfosse; Shu G Chen
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.
Human molecular genetics 2013;22(2):328-44.
2013: George Perry; Mark A Smith; Aaron A Sorensen; Xiongwei Zhu; Jesús Avila
Preface. Alzheimer's disease: advances for a new century.
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S1.
2013: Xiongwei Zhu; George Perry; Mark A Smith; Xinglong Wang
Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S253-62.
2012: Akihiko Nunomura; Rudy J Castellani; Hyoung-gon Lee; Paula I Moreira; Mark A Smith; Xiongwei Zhu; George Perry
Oxidative damage to RNA in aging and neurodegenerative disorders.
Neurotoxicity research 2012;22(3):231-48.
2012: Xinglong Wang; Hisashi Fujioka; Jun Liu; Yingchao Liu; Timothy G Petrie; Xiongwei Zhu
Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction.
Journal of neurochemistry 2012;121(5):830-9.
2012: Xinglong Wang; Gemma Casadesus Smith; Rudy J Castellani; Eric Klann; Robert B Petersen; Avneet Singh; Mark A Smith; Mike Snape; Jeremy G Stone; Xiongwei Zhu
Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome.
Journal of neurochemistry 2012;121(4):672-9.
2012: Xinglong Wang; Amy Wilson-Delfosse; Michael H Yan; Gemma Casadesus; Shu G Chen; Hisashi Fujioka; Jun Liu; George Perry; Xiongwei Zhu
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
Human molecular genetics 2012;21(9):1931-44.
2012: Renato X Santos; Mark A Smith; Xiongwei Zhu; Sónia C Correia; Hyoung-gon Lee; Akihiko Nunomura; George Perry; Robert B Petersen; Paula I Moreira
Nuclear and mitochondrial DNA oxidation in Alzheimer's disease.
Free radical research 2012;46(4):565-76.
2012: Rudy J Castellani; Paula I Moreira; George Perry; Xiongwei Zhu
The role of iron as a mediator of oxidative stress in Alzheimer disease.
BioFactors (Oxford, England) 2012;38(2):133-8.
2012: Akihiko Nunomura; George Perry; Mark A Smith; Massimo Tabaton; Toshio Tamaoki; Hyoung-gon Lee; Daniel W McKeel; Nobutaka Motohashi; Masao Nakamura; Xiongwei Zhu
The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons.
Journal of neuropathology and experimental neurology 2012;71(3):233-41.
2012: Xiongwei Zhu; Nicholas P Ziats; Rudy J Castellani; Hyoung Gon Lee; Robert B Petersen; George Perry
Mark A. Smith: neurocytochemistry innovator.
Journal of neurochemistry 2012;120(6):1139-40.
2012: Wataru Kudo; Hyun-Pil Lee; George Perry; Robert B Petersen; Mark A Smith; Xinglong Wang; Xiongwei Zhu; Wen-Quan Zou; Hyoung-gon Lee
Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.
Human molecular genetics 2012;21(5):1138-44.
2012: David J Bonda; Gang Liu; Ping Men; George Perry; Mark A Smith; Xiongwei Zhu
Nanoparticle delivery of transition-metal chelators to the brain: Oxidative stress will never see it coming!
CNS & neurological disorders drug targets 2012;11(1):81-5.
2012: Xiongwei Zhu; Gjumrakch Aliev; Rudy J Castellani; Hisashi Fujioka; Peggy L R Harris; Paula I Moreira; Lawrence M Sayre; Justin Shenk; Sandra L Siedlak; Mark A Smith; Luke I Szweda; Pamela A Szweda; George Perry
Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.
Free radical biology & medicine 2012;52(3):699-704.
2012: Janelle N Fawver; Luis V Colom; Orkid Coskuner-Weber; Karen T Duong; Rachel Petrofes Chapa; Hayley E Schall; Olivia Wise-Scira; Xiongwei Zhu; Ian V J Murray
Probing and trapping a sensitive conformation: amyloid-β fibrils, oligomers, and dimers.
Journal of Alzheimer's disease : JAD 2012;32(1):197-215.
2012: Siddhartha Mondragón-Rodríguez; Paula I Moreira; George Perry; Xiongwei Zhu; Sylvain Williams
Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target?
International journal of Alzheimer's disease 2012;2012():276803.
2012: Siddhartha Mondragón-Rodríguez; George Perry; Xiongwei Zhu; Jannic Boehm
Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy.
International journal of Alzheimer's disease 2012;2012():630182.
2012: Sónia C Correia; Paula I Moreira; George Perry; Renato X Santos; Xiongwei Zhu; Mark A Smith
Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases.
Advances in experimental medicine and biology 2012;724():205-21.
2012: Janelle N Fawver; Rachel D Petrofes Chapa; Hayley E Schall; Xiongwei Zhu; Ian V J Murray
Amyloid-β metabolite sensing: biochemical linking of glycation modification and misfolding.
Journal of Alzheimer's disease : JAD 2012;30(1):63-73.
2012: Arlene Reed-Cossairt; Xiongwei Zhu; Hyoung-gon Lee; George Perry; Charles Reed; Robert B Petersen
Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome.
Current gerontology and geriatrics research 2012;2012():929734.
2012: George Perry; Robert B Petersen; CF Phelix; Rudy J Castellani; Luis V Colom; Hyoung-gon Lee; Akihiko Nunomura; Xiongwei Zhu
Untangling the vascular web from Alzheimer disease and oxidative stress.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2012;39(1):4.
2012: Hyun-Pil Lee; Neel Pancholi; Laura A Previll; Mark A Smith; Xinglong Wang; Xiongwei Zhu; Luke Esposito; Hyoung-gon Lee
Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity.
PloS one 2012;7(1):e28033.
2011: Rudy J Castellani; Jeff M Coller; Yashi Gupta; Peggy Lr Harris; Hyoung-gon Lee; George Perry; Baiyang Sheng; Sandra L Siedlak; Mark A Smith; Massimo Tabaton; Xinglong Wang; Xiongwei Zhu
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
Laboratory investigation; a journal of technical methods and pathology 2011;91(12):1777-86.
2011: Hyun-Pil Lee; Mark A Smith; Xiongwei Zhu; Wataru Kudo; Hyoung-gon Lee
Early induction of c-Myc is associated with neuronal cell death.
Neuroscience letters 2011;505(2):124-7.
2011: Rudy J Castellani; Hyoung-gon Lee; Robert B Petersen; Xiongwei Zhu; George Perry
Mark A. Smith: the scientist, the man.
International journal of experimental pathology 2011;92(5):297-8.
2011: Xinglong Wang; Rudy J Castellani; Yuan Gao; Xiaohua He; Wanhong Liu; George Perry; Mark A. Smith; Bo Su; Xiongwei Zhu
DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease.
Aging cell 2011;10(5):807-23.
2011: Vladan P Bajić; Ninoslav Djelic; Lara M Fahmy; Wataru Kudo; Hyoung-gon Lee; Zorana Milicevic; Sandra L Siedlak; Avneet K Singh; Mark A. Smith; Biljana Spremo-Potparević; Bo Su; Xinglong Wang; Lada Zivković; Xiongwei Zhu
Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease.
Cellular & molecular biology letters 2011;16(3):359-72.
2011: Jeremy G Stone; Massimo Tabaton; Xiongwei Zhu; Rudy J Castellani; Asao Hirano; George Perry; Corrado Santocanale; Sandra L Siedlak; Mark A. Smith; Hyoung-gon Lee
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.
Journal of neuropathology and experimental neurology 2011;70(7):578-87.
2011: Julie A Wolfram; Xiongwei Zhu; Brian D Hoit; Anna Liner; Sandy L Richardson; Mark A. Smith; Hyoung-gon Lee
The role of E2F1 in the development of hypertrophic cardiomyopathy.
International journal of clinical and experimental pathology 2011;4(5):521-5.
2011: Wen-Quan Zou; Xiangzhu Xiao; Jue Yuan; Gianfranco Puoti; Hisashi Fujioka; Xinglong Wang; Sandy Richardson; Xiaochen Zhou; Roger Zou; Shihao Li; Xiongwei Zhu; Patrick L McGeer; John McGeehan; Geoff Kneale; Diego E Rincon-Limas; Pedro Fernandez-Funez; Hyoung-gon Lee; Mark A. Smith; Robert B Petersen; Jian-Ping Guo
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
The Journal of biological chemistry 2011;286(17):15095-105.
2011: Sónia C Correia; Renato X Santos; George Perry; Xiongwei Zhu; Paula I Moreira; Mark A. Smith
Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?
Ageing research reviews 2011;10(2):264-73.
2011: David J Bonda; Hyoung-gon Lee; Antoni Camins; Mercè Pallàs; Gemma Casadesus Smith; Mark A. Smith; Xiongwei Zhu
The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations.
Lancet neurology 2011;10(3):275-9.
2011: David J Bonda; Hyoung-gon Lee; Jeffrey A Blair; Xiongwei Zhu; George Perry; Mark A. Smith
Role of metal dyshomeostasis in Alzheimer's disease.
Metallomics : integrated biometal science 2011;3(3):267-70.
2011: Nicholas P Ziats; Rudy J Castellani; Hyoung-gon Lee; George Perry; Robert B Petersen; Xiongwei Zhu
Mark A. Smith, 1965-2010: consummate student of pathogenesis.
International journal of clinical and experimental pathology 2011;4(7):731-2.
2011: Quan Liu; Paula I Moreira; Mark A. Smith; Fang Xie; Xiongwei Zhu; Abdiel Alvarado-Diaz; George Perry
Neurofilamentopathy in neurodegenerative diseases.
The open neurology journal 2011;5():58-62.
2011: David J Bonda; Hyoung-gon Lee; George Perry; Mark A Smith; Xinglong Wang; Xiongwei Zhu
The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention.
Current pharmaceutical design 2011;17(31):3374-80.
2011: Jeremy G Stone; Xinglong Wang; Xiongwei Zhu; Gemma Casadesus Smith; Rudy J Castellani; Kasia Gustaw-Rothenberg; George Perry; Sandra L Siedlak; Mark A Smith
Frontiers in Alzheimer's disease therapeutics.
Therapeutic advances in chronic disease 2011;2(1):9-23.
2011: Calvin Moh; Jacek Z Kubiak; Bajic Vladan; Xiongwei Zhu; Mark A. Smith; Hyoung-gon Lee
Cell cycle deregulation in the neurons of Alzheimer's disease.
Results and problems in cell differentiation 2011;53():565-76.
2011: George Perry; Xiongwei Zhu
Mark Anthony Smith (1965-2010): Visionary, Alzheimer researcher, and editor-in-chief of the Journal of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD 2011;24(1):1-2.
2011: Rudy J Castellani; Summer L Nugent; AL Morrison; Xiongwei Zhu; Hyoung-gon Lee; Peggy L R Harris; Vladan Bajić; Hari S Sharma; Shu G Chen; Peter Oettgen; George Perry; Mark A. Smith
CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996) 2011;118(1):23-6.
2010: Jonathon E Heath; Sandra L Siedlak; Xiongwei Zhu; Hyoung-gon Lee; Akanksha Thakur; Riqiang Yan; George Perry; Mark A. Smith; Rudy J Castellani
Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Neuropathology : official journal of the Japanese Society of Neuropathology 2010;30(6):574-9.
2010: Barney E Dwyer; Leo R Zacharski; Dominic J Balestra; Alan J Lerner; George Perry; Xiongwei Zhu; Mark A. Smith
Potential role of iron in a Mediterranean-style diet.
Archives of neurology 2010;67(10):1286-7; author reply 1287-8.
2010: Chen Yao; Rabih El Khoury; Wen Wang; Tara A Byrd; Elizabeth A Pehek; Colin Thacker; Xiongwei Zhu; Mark A. Smith; Amy L Wilson-Delfosse; Shu G Chen
LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.
Neurobiology of disease 2010;40(1):73-81.
2010: David J Bonda; Xinglong Wang; George Perry; Akihiko Nunomura; Massimo Tabaton; Xiongwei Zhu; Mark A. Smith
Oxidative stress in Alzheimer disease: a possibility for prevention.
Neuropharmacology 2010;59(4-5):290-4.
2010: María F Galindo; Ichiro Ikuta; Xiongwei Zhu; Gemma Casadesus; Joaquín Jordán
Mitochondrial biology in Alzheimer's disease pathogenesis.
Journal of neurochemistry 2010;114(4):933-45.
2010: Paula I Moreira; Renato X Santos; Xiongwei Zhu; Hyoung-gon Lee; Mark A. Smith; Gemma Casadesus; George Perry
Autophagy in Alzheimer's disease.
Expert review of neurotherapeutics 2010;10(7):1209-18.
2010: Hyun Pil Lee; Xiongwei Zhu; Gemma Casadesus; Rudy J Castellani; Akihiko Nunomura; Mark A. Smith; Hyoung-gon Lee; George Perry
Antioxidant approaches for the treatment of Alzheimer's disease.
Expert review of neurotherapeutics 2010;10(7):1201-8.
2010: Bo Su; Xinglong Wang; David Bonda; George Perry; Mark A. Smith; Xiongwei Zhu
Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?
Molecular neurobiology 2010;41(2-3):87-96.
2010: Elena Bevilacqua; Xinglong Wang; Mithu Majumder; Francesca Gaccioli; Celvie L Yuan; Chuanping Wang; Xiongwei Zhu; Lindsay E Jordan; Donalyn Scheuner; Randal J Kaufman; Antonis E Koromilas; Martin D Snider; Martin Holcik; Maria Hatzoglou
eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.
The Journal of biological chemistry 2010;285(22):17098-111.
2010: Siddhartha Mondragón-Rodríguez; Gustavo Basurto-Islas; Hyoung-gon Lee; George Perry; Xiongwei Zhu; Rudy J Castellani; Mark A. Smith
Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis.
Expert review of neurotherapeutics 2010;10(5):683-91.
2010: Hyun-pil Lee; Xiongwei Zhu; Gang Liu; Shu G Chen; George Perry; Mark A. Smith; Hyoung-gon Lee
Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship.
Cell research 2010;20(4):397-9.
2010: D J Bonda; V P Bajić; Biljana Spremo-Potparevic; Gemma Casadesus Smith; Xiongwei Zhu; Mark A. Smith; Hyoung-gon Lee
Review: cell cycle aberrations and neurodegeneration.
Neuropathology and applied neurobiology 2010;36(2):157-63.
2010: Xiongwei Zhu
Ultrashort high quality electron beam from laser wakefield accelerator using two-step plasma density profile.
The Review of scientific instruments 2010;81(3):033307.
2010: David J Bonda; Xinglong Wang; George Perry; Mark A. Smith; Xiongwei Zhu
Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies.
Drugs & aging 2010;27(3):181-92.
2010: David J Bonda; Hyun-Pil Lee; Hyoung-gon Lee; Avi L Friedlich; George Perry; Xiongwei Zhu; Mark A. Smith
Novel therapeutics for Alzheimer's disease: an update.
Current opinion in drug discovery & development 2010;13(2):235-46.
2010: Akihiko Nunomura; Toshio Tamaoki; Koich Tanaka; Nobutaka Motohashi; Masao Nakamura; Takaaki Hayashi; Haruyasu Yamaguchi; Shun Shimohama; Hyoung-gon Lee; Xiongwei Zhu; Mark A. Smith; George Perry
Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease.
Neurobiology of disease 2010;37(3):731-7.
2010: Katarzyna Gustaw-Rothenberg; Alan Lerner; David J Bonda; Hyoung-gon Lee; Xiongwei Zhu; George Perry; Mark A. Smith
Biomarkers in Alzheimer's disease: past, present and future.
Biomarkers in medicine 2010;4(1):15-26.
2010: Massimo Tabaton; George Perry; Xiongwei Zhu; Hyoung-gon Lee; Gemma Casadesus; Mark A. Smith
Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease.
The American journal of pathology 2010;176(2):540-1.
2010: Kathryn J Bryan; Joseph C Mudd; Sandy L Richardson; Jaewon Chang; Hyoung-gon Lee; Xiongwei Zhu; Mark A. Smith; Gemma Casadesus Smith
Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits.
Journal of neurochemistry 2010;112(4):870-81.
2010: Bo Su; Xinglong Wang; Hyoung-gon Lee; Massimo Tabaton; George Perry; Mark A. Smith; Xiongwei Zhu
Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells.
Neuroscience letters 2010;468(3):267-71.
2010: Sónia C Correia; cristina carvalho; Susana Cardoso; Renato X Santos; Maria S Santos; Catarina R Oliveira; George Perry; Xiongwei Zhu; Mark A. Smith; Paula I Moreira
Mitochondrial preconditioning: a potential neuroprotective strategy.
Frontiers in aging neuroscience 2010;2():.
2010: David J Bonda; Maneesh Mailankot; Jeremy G Stone; Matthew R Garrett; Magdalena Staniszewska; Rudy J Castellani; Sandra L Siedlak; Xiongwei Zhu; Hyoung-gon Lee; George Perry; Ram H Nagaraj; Mark A. Smith
Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease.
Redox report : communications in free radical research 2010;15(4):161-8.
2010: Renato X Santos; Sónia C Correia; Xinglong Wang; George Perry; Mark A. Smith; Paula I Moreira; Xiongwei Zhu
Alzheimer's disease: diverse aspects of mitochondrial malfunctioning.
International journal of clinical and experimental pathology 2010;3(6):570-81.
2010: David J Bonda; Hyun-pil Lee; Wataru Kudo; Xiongwei Zhu; Mark A. Smith; Hyoung-gon Lee
Pathological implications of cell cycle re-entry in Alzheimer disease.
Expert reviews in molecular medicine 2010;12():e19.
2010: Sónia C Correia; Renato X Santos; George Perry; Xiongwei Zhu; Paula I Moreira; Mark A. Smith
Mitochondria: the missing link between preconditioning and neuroprotection.
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2():S475-85.
2010: Renato X Santos; Sónia C Correia; Xinglong Wang; George Perry; Mark A. Smith; Paula I Moreira; Xiongwei Zhu
A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2010;20 Suppl 2():S401-12.
2010: Steven J Greco; Kathryn J Bryan; Sraboni Sarkar; Xiongwei Zhu; Mark A. Smith; J Wesson Ashford; Jane M Johnston; Nikolaos Tezapsidis; Gemma Casadesus Smith
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2010;19(4):1155-67.
2010: Xinglong Wang; George Perry; Mark A. Smith; Xiongwei Zhu
Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons.
Neuro-degenerative diseases 2010;7(1-3):56-9.
2010: Mark A. Smith; Xiongwei Zhu; Massimo Tabaton; Gang Liu; Daniel W McKeel; Mark L Cohen; Xinglong Wang; Sandra L Siedlak; Barney E Dwyer; Takaaki Hayashi; Masao Nakamura; Akihiko Nunomura; George Perry
Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.
Journal of Alzheimer's disease : JAD 2010;19(1):363-72.
2010: Paula I Moreira; Lawrence M Sayre; Xiongwei Zhu; Akihiko Nunomura; Mark A. Smith; George Perry
Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease.
Methods in molecular biology (Clifton, N.J.) 2010;610():419-34.
2010: Xiongwei Zhu
Mitochondrial dysfunction: mitochondrial diseases and pathways with a focus on neurodegeneration. Preface.
Biochimica et biophysica acta 2010;1802(1):1.
2010: Paula I Moreira; cristina carvalho; Xiongwei Zhu; Mark A. Smith; George Perry
Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology.
Biochimica et biophysica acta 2010;1802(1):2-10.
2010: Paula I Moreira; Xiongwei Zhu; Xinglong Wang; Hyoung-gon Lee; Akihiko Nunomura; Robert B Petersen; George Perry; Mark A. Smith
Mitochondria: a therapeutic target in neurodegeneration.
Biochimica et biophysica acta 2010;1802(1):212-20.
2010: Bo Su; Xinglong Wang; Ling Zheng; George Perry; Mark A. Smith; Xiongwei Zhu
Abnormal mitochondrial dynamics and neurodegenerative diseases.
Biochimica et biophysica acta 2010;1802(1):135-42.
2010: Massimo Tabaton; Xiongwei Zhu; George Perry; Mark A. Smith; Luca Giliberto
Signaling effect of amyloid-beta(42) on the processing of AbetaPP.
Experimental neurology 2010;221(1):18-25.
2009: George Perry; Paula I Moreira; Sandra L Siedlak; Akihiko Nunomura; Xiongwei Zhu; Mark A. Smith
Natural oxidant balance in Parkinson disease.
Archives of neurology 2009;66(12):1445.
2009: Hyun-Pil Lee; Gemma Casadesus Smith; Xiongwei Zhu; Hyoung-gon Lee; George Perry; Mark A. Smith; Katarzyna Gustaw-Rothenberg; Alan Lerner
All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease.
Expert review of neurotherapeutics 2009;9(11):1615-21.
2009: cristina carvalho; Sónia C Correia; Renato X Santos; Susana Cardoso; Paula I Moreira; Timothy A Clark; Xiongwei Zhu; Mark A. Smith; George Perry
Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia.
Journal of bioenergetics and biomembranes 2009;41(5):433-40.
2009: Barney E Dwyer; Meghan L Stone; Nadia Gorman; Peter R Sinclair; George Perry; Mark A. Smith; Xiongwei Zhu
Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease.
Neuroscience letters 2009;461(3):302-5.
2009: Barney E Dwyer; Mark A. Smith; Sandy L Richardson; George Perry; Xiongwei Zhu
Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease.
Neuroscience letters 2009;460(2):180-4.
2009: Xinglong Wang; Bo Su; Hyoung-gon Lee; Xinyi Li; George Perry; Mark A. Smith; Xiongwei Zhu
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(28):9090-103.
2009: Mar Perez; Ismael Santa-Maria; Elena Gomez de Barreda; Xiongwei Zhu; Raquel Cuadros; Jose Roman Cabrero; Francisco Sanchez-Madrid; Hana N. Dawson; Michael P. Vitek; George Perry; Mark A. Smith; Jesús Avila
Tau--an inhibitor of deacetylase HDAC6 function.
Journal of neurochemistry 2009;109(6):1756-66.
2009: Steven J Greco; Sraboni Sarkar; Gemma Casadesus Smith; Xiongwei Zhu; Mark A. Smith; J Wesson Ashford; Jane M Johnston; Nikolaos Tezapsidis
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
Neuroscience letters 2009;455(3):191-4.
2009: Xinglong Wang; Bo Su; Ling Zheng; George Perry; Mark A. Smith; Xiongwei Zhu
The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease.
Journal of neurochemistry 2009;109 Suppl 1():153-9.
2009: Barney E Dwyer; Leo R Zacharski; Dominic J Balestra; Alan J Lerner; George Perry; Xiongwei Zhu; Mark A. Smith
Getting the iron out: phlebotomy for Alzheimer's disease?
Medical hypotheses 2009;72(5):504-9.
2009: Luca Giliberto; Roberta Borghi; Alessandra Piccini; Rosa Mangerini; Sandro Sorbi; Gabriella Cirmena; Anna Garuti; Bernardino Ghetti; Fabrizio Tagliavini; Mohamed R Mughal; Mark P Mattson; Xiongwei Zhu; Xinglong Wang; Michela Guglielmotto; Elena Tamagno; Massimo Tabaton
Mutant presenilin 1 increases the expression and activity of BACE1.
The Journal of biological chemistry 2009;284(14):9027-38.
2009: Marta Tajes; Marc Yeste-Velasco; Xiongwei Zhu; Steven P Chou; Mark A. Smith; Merce Pallas; Antoni Camins; Gemma Casadesús
Activation of Akt by lithium: pro-survival pathways in aging.
Mechanisms of ageing and development 2009;130(4):253-61.
2009: Rudy J Castellani; Xiongwei Zhu; Hyoung-gon Lee; Mark A. Smith; George Perry
Molecular pathogenesis of Alzheimer's disease: Reductionist versus expansionist approaches.
International journal of molecular sciences 2009;10(3):1386-406.
2009: Hyun-Pil Lee; Xiongwei Zhu; Xiaochun Zhu; S Chad Skidmore; George Perry; Lawrence M Sayre; Mark A. Smith; Hyoung-gon Lee
The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells.
Journal of neurochemistry 2009;108(6):1434-41.
2009: Hyoung-gon Lee; Gemma Casadesus Smith; Akihiko Nunomura; Xiongwei Zhu; Rudy J Castellani; Sandy L Richardson; George Perry; Dean W Felsher; Robert B Petersen; Mark A. Smith
The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse.
The American journal of pathology 2009;174(3):891-7.
2009: George Perry; Xiongwei Zhu; Paula I Moreira; Mark A. Smith
Altered redox balance in disease: can we change the new equilibria?
Annals of neurology 2009;65(2):121-3.
2009: Hyoung-gon Lee; Gemma Casadesus Smith; Xiongwei Zhu; Rudy J Castellani; Andy McShea; George Perry; Robert B Petersen; Bajic Vladan; Mark A. Smith
Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease.
Neurochemistry international 2009;54(2):84-8.
2009: Emma Ramiro-Puig; Gemma Casadesús; Hyoung-gon Lee; Xiongwei Zhu; Andy McShea; George Perry; Francisco J Pérez-Cano; Mark A. Smith; Margarida Castell
Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress.
European journal of nutrition 2009;48(1):54-61.
2009: Hyoung-gon Lee; Xiongwei Zhu; Gemma Casadesus Smith; Merce Pallas; Antoni Camins; Michael J O'Neill; Shigetada Nakanishi; George Perry; Mark A. Smith
The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
Brain research 2009;1249():244-50.
2009: Avi L Friedlich; Raj K Rolston; Xiongwei Zhu; Michael W Marlatt; Rudy J Castellani; Akihiko Nunomura; Hyoung-gon Lee; Gemma Casadesus; George Perry; Mark A. Smith
Treatment advances in Alzheimer's disease based on the oxidative stress model.
F1000 medicine reports 2009;1():.
2009: Hyoung-gon Lee; Qun Chen; Julie A Wolfram; Sandy L Richardson; Anna Liner; Sandra L Siedlak; Xiongwei Zhu; Nicholas P Ziats; Hisashi Fujioka; Dean W Felsher; Rudy J Castellani; Maria L Valencik; John A McDonald; Brian D Hoit; Edward J Lesnefsky; Mark A. Smith
Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure.
PloS one 2009;4(9):e7172.
2009: Bo Su; Haihua Liu; Xinglong Wang; Shu G Chen; Sandra L Siedlak; Eisaku Kondo; Raymond Choi; Atsushi Takeda; Rudy J Castellani; George Perry; Mark A. Smith; Xiongwei Zhu; Hyoung-gon Lee
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease.
Molecular neurodegeneration 2009;4():32.
2009: Rudy J Castellani; Hyoung-gon Lee; Sandra L Siedlak; Akihiko Nunomura; Takaaki Hayashi; Masao Nakamura; Xiongwei Zhu; George Perry; Mark A. Smith
Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta.
Journal of Alzheimer's disease : JAD 2009;18(2):447-52.
2009: Susana Cardoso; Sónia Correia; Renato X Santos; cristina carvalho; Maria S Santos; Catarina R Oliveira; George Perry; Mark A. Smith; Xiongwei Zhu; Paula I Moreira
Insulin is a two-edged knife on the brain.
Journal of Alzheimer's disease : JAD 2009;18(3):483-507.
2009: V Prakash Reddy; Xiongwei Zhu; George Perry; Mark A. Smith
Oxidative stress in diabetes and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2009;16(4):763-74.
2009: Nikolaos Tezapsidis; Jane M Johnston; Mark A. Smith; J Wesson Ashford; Gemma Casadesus Smith; Nikolaos K Robakis; Benjamin Wolozin; George Perry; Xiongwei Zhu; Steven J Greco; Sraboni Sarkar
Leptin: a novel therapeutic strategy for Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2009;16(4):731-40.
2008: Xinglong Wang; Bo Su; Sandra L Siedlak; Paula I Moreira; Hisashi Fujioka; Yang Wang; Gemma Casadesus Smith; Xiongwei Zhu
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19318-23.
2008: Na-Hye Myung; Xiongwei Zhu; Inna I Kruman; Rudy J Castellani; Robert B Petersen; Sandra L Siedlak; George Perry; Mark A. Smith; Hyoung-gon Lee
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.
Age (Dordrecht, Netherlands) 2008;30(4):209-15.
2008: B Su; X Wang; A Nunomura; P I Moreira; H-gon Lee; George Perry; Mark A. Smith; Xiongwei Zhu
Oxidative stress signaling in Alzheimer's disease.
Current Alzheimer research 2008;5(6):525-32.
2008: Steven J Greco; Sraboni Sarkar; Jane Johnston; Xiongwei Zhu; Bo Su; Gemma Casadesus Smith; J Wesson Ashford; Mark A. Smith; Nikolaos Tezapsidis
Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells.
Biochemical and biophysical research communications 2008;376(3):536-41.
2008: Gjumrakch Aliev; Mark E Obrenovich; V Prakash Reddy; Justin Shenk; Paula I Moreira; Akihiko Nunomura; Xiongwei Zhu; Mark A. Smith; George Perry
Antioxidant therapy in Alzheimer's disease: theory and practice.
Mini reviews in medicinal chemistry 2008;8(13):1395-406.
2008: Emma K Larkin; Sanjay R Patel; Robert C Elston; Courtney Gray-McGuire; Xiongwei Zhu; Susan Redline
Using linkage analysis to identify quantitative trait loci for sleep apnea in relationship to body mass index.
Annals of human genetics 2008;72(Pt 6):762-73.
2008: Michael W Marlatt; Paul J Lucassen; George Perry; Mark A. Smith; Xiongwei Zhu
Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies.
Journal of Alzheimer's disease : JAD 2008;15(2):199-210.
2008: Xinglong Wang; Bo Su; Hisashi Fujioka; Xiongwei Zhu
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients.
The American journal of pathology 2008;173(2):470-82.
2008: Katarzyna A Gustaw; Matthew R Garrett; Hyoung-gon Lee; Rudy J Castellani; Michael G Zagorski; Annamalai Prakasam; Sandra L Siedlak; Xiongwei Zhu; George Perry; Robert B Petersen; Robert P Friedland; Mark A. Smith
Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis.
Journal of neurochemistry 2008;106(3):1350-6.
2008: Xiongwei Zhu; S L Siedlak; Yanming Wang; George Perry; Rudy J Castellani; M L Cohen; Mark A. Smith
Neuronal binucleation in Alzheimer disease hippocampus.
Neuropathology and applied neurobiology 2008;34(4):457-65.
2008: Rudy J Castellani; Hyoung-gon Lee; Xiongwei Zhu; George Perry; Mark A. Smith
Alzheimer disease pathology as a host response.
Journal of neuropathology and experimental neurology 2008;67(6):523-31.
2008: Bo Su; Xinglong Wang; Kelly L Drew; George Perry; Mark A. Smith; Xiongwei Zhu
Physiological regulation of tau phosphorylation during hibernation.
Journal of neurochemistry 2008;105(6):2098-108.
2008: Payal N Gandhi; Xinglong Wang; Xiongwei Zhu; Shu G Chen; Amy L Wilson-Delfosse
The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules.
Journal of neuroscience research 2008;86(8):1711-20.
2008: Y Wu; X Wang; X Mo; Z Xi; F Xiao; J Li; Xiongwei Zhu; G Luan; Y Wang; Y Li; J Zhang
Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy.
Clinical neuropathology 2008;27(2):55-63.
2008: Paula I Moreira; Maria S Santos; Catarina R Oliveira; Justin Shenk; Akihiko Nunomura; Mark A. Smith; Xiongwei Zhu; George Perry
Alzheimer disease and the role of free radicals in the pathogenesis of the disease.
CNS & neurological disorders drug targets 2008;7(1):3-10.
2008: Daniel J Klionsky; Hagai Abeliovich; Patrizia Agostinis; Devendra K Agrawal; Gjumrakch Aliev; David S Askew; Misuzu Baba; Eric H Baehrecke; Ben A Bahr; Andrea Ballabio; Bruce A Bamber; Diane C Bassham; Ettore Bergamini; Xiaoning Bi; Martine Biard-Piechaczyk; Janice S Blum; Dale E Bredesen; Jeffrey L Brodsky; John H Brumell; Ulf T Brunk; Wilfried Bursch; Nadine Camougrand; Eduardo Cebollero; Francesco Cecconi; Yingyu Chen; Lih-Shen Chin; Augustine Choi; Charleen T Chu; Jongkyeong Chung; Peter G H Clarke; Robert S B Clark; Steven G Clarke; Corinne Clavé; John L Cleveland; Patrice Codogno; María I Colombo; Ana Coto-Montes; James M Cregg; Ana Maria Cuervo; Jayanta Debnath; Francesca Demarchi; Patrick B Dennis; Phillip A Dennis; Vojo Deretic; Rodney J Devenish; Federica Di Sano; J Fred Dice; Marian DiFiglia; Savithramma Dinesh-Kumar; Clark W Distelhorst; Mojgan Djavaheri-Mergny; Frank C Dorsey; Wulf Dröge; Michel Dron; William A Dunn; Michael Duszenko; N Tony Eissa; Zvulun Elazar; Audrey Esclatine; Eeva-Liisa Eskelinen; László Fésüs; Kim D Finley; Jose M. Fuentes; Juan Fueyo; Kozo Fujisaki; Brigitte Galliot; Fen-Biao Gao; David Gewirtz; Spencer B Gibson; Antje Gohla; Alfred L Goldberg; Ramon Gonzalez; Cristina González-Estévez; Sharon Gorski; Roberta Anne Gottlieb; Dieter Häussinger; You-Wen He; Kim Heidenreich; Joseph A Hill; Maria Høyer-Hansen; Xun Hu; Wei-Pang Huang; Akiko Iwasaki; Marja Jäättelä; William T Jackson; Xuejun Jiang; Shengkan Jin; Terje Johansen; Jae U. Jung; Motoni Kadowaki; Chanhee Kang; Ameeta Kelekar; David Kessel; Jan A K W Kiel; hong pyo kim; Adi Kimchi; Timothy J Kinsella; Kirill Kiselyov; Katsuhiko Kitamoto; Erwin Knecht; Masaaki Komatsu; Eiki Kominami; Seiji Kondo; Attila L Kovács; Guido Kroemer; Chia-Yi Kuan; Rakesh Kumar; Mondira Kundu; Jacques Landry; Marianne Laporte; Weidong Le; Huan-Yao Lei; Michael J Lenardo; Beth Levine; Andrew P Lieberman; Kah-Leong Lim; Fu-Cheng Lin; Willisa Liou; Leroy F Liu; Gabriel Lopez-Berestein; Carlos López-Otín; Bo Lu; Kay F Macleod; Walter Malorni; Wim Martinet; Ken Matsuoka; Josef Mautner; Alfred J Meijer; Alicia Meléndez; Paul Michels; Giovanni Miotto; wilhelm mistiaen; Noboru Mizushima; Baharia Mograbi; Iryna Monastyrska; Michael N Moore; Paula I Moreira; Yuji Moriyasu; Tomasz Motyl; Christian Münz; Leon O Murphy; Naweed I Naqvi; Thomas P Neufeld; Ichizo Nishino; Ralph A. Nixon; takeshi noda; Bernd Nürnberg; Michinaga Ogawa; Nancy L Oleinick; Laura J Olsen; Bulent Ozpolat; Shoshana Paglin; Glen E Palmer; Issidora Papassideri; Miles Parkes; David H Perlmutter; George Perry; Mauro Piacentini; Ronit Pinkas-Kramarski; Mark Prescott; Tassula Proikas-Cezanne; Nina Raben; Abdelhaq Rami; Fulvio Reggiori; Bärbel Rohrer; David C Rubinsztein; Kevin M Ryan; Junichi Sadoshima; Hiroshi Sakagami; Yasuyoshi Sakai; Marco Sandri; Chihiro Sasakawa; Miklós Sass; Claudio Schneider; Per O Seglen; Oleksandr Seleverstov; Jeffrey Settleman; John J Shacka; Irving M Shapiro; Andrei Sibirny; Elaine C M Silva-Zacarin; Hans-Uwe Simon; Cristiano Simone; Anne Simonsen; Mark A. Smith; Katharina Spanel-Borowski; Vickram Srinivas; Meredith Steeves; Harald Stenmark; Per E Stromhaug; Carlos S Subauste; Seiichiro Sugimoto; David Sulzer; Toshihiko Suzuki; Michele S Swanson; Ira Tabas; Fumihiko Takeshita; Nicholas J Talbot; Zsolt Tallóczy; Keiji Tanaka; Kozo Tanaka; Isei Tanida; Graham S Taylor; J. Paul Taylor; Alexei Terman; Gianluca Tettamanti; Craig Thompson; Michael Thumm; Aviva M Tolkovsky; Sharon A Tooze; Ray Truant; Lesya V Tumanovska; Yasuo Uchiyama; Takashi Ueno; Néstor L Uzcátegui; Ida van der Klei; Eva C Vaquero; Tibor Vellai; Michael W Vogel; Hong-Gang Wang; Paul Webster; John W Wiley; Zhijun Xi; Gutian Xiao; Joachim Yahalom; Jin-Ming Yang; George Yap; Xiao-Ming Yin; Tamotsu Yoshimori; Li Yu; Zhenyu Yue; Michisuke Yuzaki; Olga Zabirnyk; Xiaoxiang Zheng; Xiongwei Zhu; Russell L Deter
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy 2008;4(2):151-75.
2008: Elena Tamagno; Michela Guglielmotto; Manuela Aragno; Roberta Borghi; Riccardo Autelli; Luca Giliberto; Giuseppe Muraca; Oliviero Danni; Xiongwei Zhu; Mark A. Smith; George Perry; Dong-Gyu Jo; Mark P Mattson; Massimo Tabaton
Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein.
Journal of neurochemistry 2008;104(3):683-95.
2008: Kathryn J Bryan; Xiongwei Zhu; Peggy L R Harris; George Perry; Rudy J Castellani; Mark A. Smith; Gemma Casadesus Smith
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease.
Molecular neurodegeneration 2008;3():13.
2008: George Perry; Rudy J Castellani; Paula I Moreira; Hyoung-gon Lee; Xiongwei Zhu; Mark A. Smith
Pathology's new role: defining disease process and protective responses.
International journal of clinical and experimental pathology 2008;1(1):1-4.
2008: Akanksha Thakur; Sandra L Siedlak; Sheronica L James; David J Bonda; Akanksha Rao; Kate M Webber; Antoni Camins; Merce Pallas; Gemma Casadesus Smith; Hyoung-gon Lee; Robert Bowser; Arun K Raina; George Perry; Mark A. Smith; Xiongwei Zhu
Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
International journal of clinical and experimental pathology 2008;1(2):134-46.
2008: George Perry; Xiongwei Zhu; Asim K Babar; Sandra L Siedlak; Qiwei Yang; Genta Ito; Takeshi Iwatsubo; Mark A. Smith; Shu G Chen
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Neuro-degenerative diseases 2008;5(3-4):222-4.
2007: Xinglong Wang; Bo Su; George Perry; Mark A. Smith; Xiongwei Zhu
Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease.
Free radical biology & medicine 2007;43(12):1569-73.
2007: Akihiko Nunomura; Paula I Moreira; Hyoung-gon Lee; Xiongwei Zhu; Rudy J Castellani; Mark A. Smith; George Perry
Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases.
CNS & neurological disorders drug targets 2007;6(6):411-23.
2007: Paula I Moreira; Sandra L Siedlak; Xinglong Wang; Maria S Santos; Catarina R Oliveira; Massimo Tabaton; Akihiko Nunomura; Luke I Szweda; Gjumrakch Aliev; Mark A. Smith; Xiongwei Zhu; George Perry
Increased autophagic degradation of mitochondria in Alzheimer disease.
Autophagy 2007;3(6):614-5.
2007: Rudy J Castellani; Paula I Moreira; Gang Liu; Jon Dobson; George Perry; Mark A. Smith; Xiongwei Zhu
Iron: the Redox-active center of oxidative stress in Alzheimer disease.
Neurochemical research 2007;32(10):1640-5.
2007: Paula I Moreira; Peggy L R Harris; Xiongwei Zhu; Maria S Santos; Catarina R Oliveira; Mark A. Smith; George Perry
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.
Journal of Alzheimer's disease : JAD 2007;12(2):195-206.
2007: Xiongwei Zhu; B Su; X Wang; Mark A. Smith; George Perry
Causes of oxidative stress in Alzheimer disease.
Cellular and molecular life sciences : CMLS 2007;64(17):2202-10.
2007: Jie Li; Xuechun Xia; Yibao Ke; Huiling Nie; Mark A. Smith; Xiongwei Zhu
Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways.
Biochimica et biophysica acta 2007;1770(8):1169-80.
2007: Xiongwei Zhu; Mark A. Smith; Kazuhiro Honda; Gjumrakch Aliev; Paula I Moreira; Akihiko Nunomura; Gemma Casadesus Smith; Peggy L R Harris; Sandra L Siedlak; George Perry
Vascular oxidative stress in Alzheimer disease.
Journal of the neurological sciences 2007;257(1-2):240-6.
2007: Paula I Moreira; Sandra L Siedlak; Xinglong Wang; Maria S Santos; Catarina R Oliveira; Massimo Tabaton; Akihiko Nunomura; Luke I Szweda; Gjumrakch Aliev; Mark A. Smith; Xiongwei Zhu; George Perry
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Journal of neuropathology and experimental neurology 2007;66(6):525-32.
2007: Akanksha Thakur; Xinglong Wang; Sandra L Siedlak; George Perry; Mark A. Smith; Xiongwei Zhu
c-Jun phosphorylation in Alzheimer disease.
Journal of neuroscience research 2007;85(8):1668-73.
2007: Hyoung-gon Lee; Xiongwei Zhu; Rudy J Castellani; Akihiko Nunomura; George Perry; Mark A. Smith
Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses.
The Journal of pharmacology and experimental therapeutics 2007;321(3):823-9.
2007: Robert B Petersen; Akihiko Nunomura; Hyoung-gon Lee; Gemma Casadesus Smith; George Perry; Mark A. Smith; Xiongwei Zhu
Signal transduction cascades associated with oxidative stress in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2007;11(2):143-52.
2007: Rudy J Castellani; Xiongwei Zhu; Hyoung-gon Lee; Paula I Moreira; George Perry; Mark A. Smith
Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
Expert review of neurotherapeutics 2007;7(5):473-85.
2007: Xiongwei Zhu; Jesús Avila; George Perry; Mark A. Smith
Treating the lesions, not the disease.
The American journal of pathology 2007;170(5):1457-9.
2007: Xiongwei Zhu; Hyoung-gon Lee; George Perry; Mark A. Smith
Alzheimer disease, the two-hit hypothesis: an update.
Biochimica et biophysica acta 2007;1772(4):494-502.
2007: Laura A Previll; Meredith Crosby; Rudy J Castellani; Robert Bowser; George Perry; Mark A. Smith; Xiongwei Zhu
Increased expression of p130 in Alzheimer disease.
Neurochemical research 2007;32(4-5):639-44.
2007: Quan Liu; Fang Xie; Raj Rolston; Paula I Moreira; Akihiko Nunomura; Xiongwei Zhu; Mark A. Smith; George Perry
Prevention and treatment of Alzheimer disease and aging: antioxidants.
Mini reviews in medicinal chemistry 2007;7(2):171-80.
2007: Teresa A Evans; Arun K Raina; André Delacourte; Olga Aprelikova; Hyoung-gon Lee; Xiongwei Zhu; George Perry; Mark A. Smith
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
International journal of medical sciences 2007;4(3):140-5.
2007: Gemma Casadesus Smith; Mark A. Smith; Samar Basu; Jing Hua; Dae E Capobianco; Sandra L Siedlak; Xiongwei Zhu; George Perry
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease.
Molecular neurodegeneration 2007;2():2.
2007: Jie Li; Xuechun Xia; Huiling Nie; Mark A. Smith; Xiongwei Zhu
PKC inhibition is involved in trichosanthin-induced apoptosis in human chronic myeloid leukemia cell line K562.
Biochimica et biophysica acta 2007;1770(1):63-70.
2006: Hyoung-gon Lee; Masumi Ueda; Yoichi Miyamoto; Yoshihiro Yoneda; George Perry; Mark A. Smith; Xiongwei Zhu
Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease.
Brain research 2006;1124(1):1-4.
2006: Matthew Mei; Bo Su; Kristen Harrison; Mark Chao; Sandra L Siedlak; Laura A Previll; LaMia Jackson; Dan X Cai; Xiongwei Zhu
Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
Journal of neurochemistry 2006;99(5):1377-88.
2006: Hyoung-gon Lee; Masumi Ueda; Xiongwei Zhu; George Perry; Mark A. Smith
Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?
Journal of neuroscience research 2006;84(8):1856-61.
2006: Xiongwei Zhu; Sandra L Siedlak; Mark A. Smith; George Perry; Shu G Chen
LRRK2 protein is a component of Lewy bodies.
Annals of neurology 2006;60(5):617-8; author reply 618-9.
2006: Xiongwei Zhu; Arun K Raina; George Perry; Mark A. Smith
Apoptosis in Alzheimer disease: a mathematical improbability.
Current Alzheimer research 2006;3(4):393-6.
2006: Hyoung-gon Lee; Xiongwei Zhu; Akihiko Nunomura; George Perry; Mark A. Smith
Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose!
The American journal of pathology 2006;169(3):738-9.
2006: Hyoung-gon Lee; George Perry; Xiongwei Zhu; Akihiko Nunomura; Mark A. Smith
Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression".
Free radical biology & medicine 2006;41(2):188-9.
2006: Xiongwei Zhu; George Perry; Paula I Moreira; Gjumrakch Aliev; Adam D Cash; Keisuke Hirai; Mark A. Smith
Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease.
Journal of Alzheimer's disease : JAD 2006;9(2):147-53.
2006: Akihiko Nunomura; Rudy J Castellani; Xiongwei Zhu; Paula I Moreira; George Perry; Mark A. Smith
Involvement of oxidative stress in Alzheimer disease.
Journal of neuropathology and experimental neurology 2006;65(7):631-41.
2006: Hyoung-gon Lee; Xiongwei Zhu; Atsushi Takeda; George Perry; Mark A. Smith
Emerging evidence for the neuroprotective role of alpha-synuclein.
Experimental neurology 2006;200(1):1-7.
2006: Paula I Moreira; Xiongwei Zhu; Akihiko Nunomura; Mark A. Smith; George Perry
Therapeutic options in Alzheimer's disease.
Expert review of neurotherapeutics 2006;6(6):897-910.
2006: Rudy J Castellani; Hyoung-gon Lee; Xiongwei Zhu; Akihiko Nunomura; George Perry; Mark A. Smith
Neuropathology of Alzheimer disease: pathognomonic but not pathogenic.
Acta neuropathologica 2006;111(6):503-9.
2006: Paula I Moreira; Xiongwei Zhu; Hyoung-gon Lee; Kazuhiro Honda; Mark A. Smith; George Perry
The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease.
Mechanisms of ageing and development 2006;127(6):501-6.
2006: Akihiko Nunomura; Rudy J Castellani; Hyoung-gon Lee; Paula I Moreira; Xiongwei Zhu; George Perry; Mark A. Smith
Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream.
Science of aging knowledge environment : SAGE KE 2006;2006(8):pe10.
2006: Mark A Smith; Xiongwei Zhu; Anne E Fortino; Peggy L R Harris; Hyoung-gon Lee; George Perry; Rudy J Castellani
Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy.
Age (Dordrecht, Netherlands) 2006;28(1):85-91.
2006: Xiongwei Zhu; Hyoung-gon Lee; Paula I Moreira; Mark A. Smith; George Perry
Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".
Free radical biology & medicine 2006;40(5):737-9.
2006: Hyoung-gon Lee; Xiongwei Zhu; Akihiko Nunomura; George Perry; Mark A. Smith
Amyloid beta: the alternate hypothesis.
Current Alzheimer research 2006;3(1):75-80.
2006: Paula I Moreira; K Honda; Xiongwei Zhu; Akihiko Nunomura; Gemma Casadesus Smith; Mark A. Smith; George Perry
Brain and brawn: parallels in oxidative strength.
Neurology 2006;66(2 Suppl 1):S97-101.
2006: Xiongwei Zhu; Asim Babar; Sandra L Siedlak; Qiwei Yang; Genta Ito; Takeshi Iwatsubo; Mark A. Smith; George Perry; Shu G Chen
LRRK2 in Parkinson's disease and dementia with Lewy bodies.
Molecular neurodegeneration 2006;1():17.
2006: Akihiko Nunomura; Kazuhiro Honda; Atsushi Takeda; Keisuke Hirai; Xiongwei Zhu; Mark A. Smith; George Perry
Oxidative damage to RNA in neurodegenerative diseases.
Journal of biomedicine & biotechnology 2006;2006(3):82323.
2006: Mark A. Smith; George Perry; Xiongwei Zhu; Abdelali Haoudi
Neurodegenerative diseases: mechanisms and therapies.
Journal of biomedicine & biotechnology 2006;2006(3):47539.
2006: Barney E Dwyer; Meghan L Stone; Xiongwei Zhu; George Perry; Mark A. Smith
Heme deficiency in Alzheimer's disease: a possible connection to porphyria.
Journal of biomedicine & biotechnology 2006;2006(3):24038.
2006: Kate M Webber; Douglas M Stocco; Gemma Casadesus Smith; Richard L Bowen; Craig S Atwood; Laura A Previll; Peggy L R Harris; Xiongwei Zhu; George Perry; Mark A. Smith
Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease.
Molecular neurodegeneration 2006;1():14.
2006: Paula I Moreira; Xiongwei Zhu; Quan Liu; Kazuhiro Honda; Sandra L Siedlak; Peggy L R Harris; Mark A. Smith; George Perry
Compensatory responses induced by oxidative stress in Alzheimer disease.
Biological research 2006;39(1):7-13.
2006: Hyoung-gon Lee; Xiongwei Zhu; George Perry; Mark A. Smith
The fallacy of amyloid and cognition in Alzheimer's disease.
Drugs & aging 2006;23(2):179.
2006: Kate M Webber; Gemma Casadesus Smith; Xiongwei Zhu; Mark E Obrenovich; Craig S Atwood; George Perry; Richard L Bowen; Mark A. Smith
The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target.
Current pharmaceutical design 2006;12(6):691-7.
2005: Yi Long Ma; Xiongwei Zhu; Patricia M Rivera; Øivind Tøien; Brian Barnes; Joseph C LaManna; Mark A. Smith; Kelly L Drew
Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(5):R1297-306.
2005: Paula I Moreira; Kazuhiro Honda; Quan Liu; Maria S Santos; Catarina R Oliveira; Gjumrakch Aliev; Akihiko Nunomura; Xiongwei Zhu; Mark A. Smith; George Perry
Oxidative stress: the old enemy in Alzheimer's disease pathophysiology.
Current Alzheimer research 2005;2(4):403-8.
2005: Kate M Webber; Arun K Raina; Michael W Marlatt; Xiongwei Zhu; María I Prat; Laura Morelli; Gemma Casadesus Smith; George Perry; Mark A. Smith
The cell cycle in Alzheimer disease: a unique target for neuropharmacology.
Mechanisms of ageing and development 2005;126(10):1019-25.
2005: Gang Liu; Matthew R Garrett; Ping Men; Xiongwei Zhu; George Perry; Mark A. Smith
Nanoparticle and other metal chelation therapeutics in Alzheimer disease.
Biochimica et biophysica acta 2005;1741(3):246-52.
2005: Xiongwei Zhu; Paula I Moreira; Mark A. Smith; George Perry
Alzheimer's disease: an intracellular movement disorder?
Trends in molecular medicine 2005;11(9):391-3.
2005: Barney E Dwyer; Atsushi Takeda; Xiongwei Zhu; George Perry; Mark A. Smith
Ferric cycle activity and Alzheimer disease.
Current neurovascular research 2005;2(3):261-7.
2005: Paula I Moreira; Sandra L Siedlak; Gjumrakch Aliev; Xiongwei Zhu; Adam D Cash; Mark A. Smith; George Perry
Oxidative stress mechanisms and potential therapeutics in Alzheimer disease.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(7):921-32.
2005: Xiongwei Zhu; Mark A. Smith; George Perry; Yang Wang; Austin P Ross; Huiwen W Zhao; Joseph C LaManna; Kelly L Drew
MAPKs are differentially modulated in arctic ground squirrels during hibernation.
Journal of neuroscience research 2005;80(6):862-8.
2005: Kazuhiro Honda; Mark A. Smith; Xiongwei Zhu; Diane Baus; William C Merrick; Alan M Tartakoff; Thomas Hattier; Peggy L R Harris; Sandra L Siedlak; Hisashi Fujioka; Quan Liu; Paula I Moreira; Frank P Miller; Akihiko Nunomura; Shun Shimohama; George Perry
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
The Journal of biological chemistry 2005;280(22):20978-86.
2005: Xiongwei Zhu; Matthew Mei; Hyoung-gon Lee; Yang Wang; Jiahuai Han; George Perry; Mark A. Smith
P38 activation mediates amyloid-beta cytotoxicity.
Neurochemical research 2005;30(6-7):791-6.
2005: Paula I Moreira; Mark A. Smith; Xiongwei Zhu; Akihiko Nunomura; Rudy J Castellani; George Perry
Oxidative stress and neurodegeneration.
Annals of the New York Academy of Sciences 2005;1043():545-52.
2005: Hyoung-gon Lee; Rudy J Castellani; Xiongwei Zhu; George Perry; Mark A. Smith
Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?
International journal of experimental pathology 2005;86(3):133-8.
2005: Mark A. Smith; Akihiko Nunomura; Hyoung-gon Lee; Xiongwei Zhu; Paula I Moreira; Jesús Avila; George Perry
Chronological primacy of oxidative stress in Alzheimer disease.
Neurobiology of aging 2005;26(5):579-80.
2005: Paula I Moreira; Catarina R Oliveira; Maria S Santos; Akihiko Nunomura; Kazuhiro Honda; Xiongwei Zhu; Mark A. Smith; George Perry
A second look into the oxidant mechanisms in Alzheimer's disease.
Current neurovascular research 2005;2(2):179-84.
2005: Hyoung-gon Lee; George Perry; Paula I Moreira; Matthew R Garrett; Quan Liu; Xiongwei Zhu; Atsushi Takeda; Akihiko Nunomura; Mark A. Smith
Tau phosphorylation in Alzheimer's disease: pathogen or protector?
Trends in molecular medicine 2005;11(4):164-9.
2005: Quan Liu; Mark A. Smith; Jesús Avila; John DeBernardis; Mayank M Kansal; Atsushi Takeda; Xiongwei Zhu; Akihiko Nunomura; Kazuhiro Honda; Paula I Moreira; Catarina R Oliveira; Maria S Santos; Shun Shimohama; Gjumrakch Aliev; Jack C. de la Torre; Hossein A Ghanbari; Sandra L Siedlak; Peggy L R Harris; Lawrence M Sayre; George Perry
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations.
Free radical biology & medicine 2005;38(6):746-54.
2005: Kate M Webber; Mark A. Smith; Hyoung-gon Lee; Peggy L R Harris; Paula I Moreira; George Perry; Xiongwei Zhu
Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
Journal of neuroscience research 2005;79(4):554-60.
2005: Xiongwei Zhu; George Perry; Mark A. Smith
Insulin signaling, diabetes mellitus and risk of Alzheimer disease.
Journal of Alzheimer's disease : JAD 2005;7(1):81-4.
2005: Gemma Casadesus Smith; Craig S Atwood; Xiongwei Zhu; Anthony W Hartzler; Kate M Webber; George Perry; Richard L Bowen; Mark A. Smith
Evidence for the role of gonadotropin hormones in the development of Alzheimer disease.
Cellular and molecular life sciences : CMLS 2005;62(3):293-8.
2005: Quan Liu; Hyoung-gon Lee; Kazuhiro Honda; Sandra L Siedlak; Peggy L R Harris; Adam D Cash; Xiongwei Zhu; Jesús Avila; Akihiko Nunomura; Atsushi Takeda; Mark A. Smith; George Perry
Tau modifiers as therapeutic targets for Alzheimer's disease.
Biochimica et biophysica acta 2005;1739(2-3):211-5.
2005: Xiongwei Zhu; Hyoung-gon Lee; Gemma Casadesus Smith; Jesús Avila; Kelly L Drew; George Perry; Mark A. Smith
Oxidative imbalance in Alzheimer's disease.
Molecular neurobiology 2005;31(1-3):205-17.
2005: Michael W Marlatt; Kate M Webber; Paula I Moreira; Hyoung-gon Lee; Gemma Casadesus Smith; Kazuhiro Honda; Xiongwei Zhu; George Perry; Mark A. Smith
Therapeutic opportunities in Alzheimer disease: one for all or all for one?
Current medicinal chemistry 2005;12(10):1137-47.
2005: Paula I Moreira; Mark A. Smith; Xiongwei Zhu; Kazuhiro Honda; Hyoung-gon Lee; Gjumrakch Aliev; George Perry
Oxidative damage and Alzheimer's disease: are antioxidant therapies useful?
Drug news & perspectives 2005;18(1):13-9.
2004: Paula I Moreira; Mark A. Smith; Xiongwei Zhu; Maria S Santos; Catarina R Oliveira; George Perry
Therapeutic potential of oxidant mechanisms in Alzheimer's disease.
Expert review of neurotherapeutics 2004;4(6):995-1004.
2004: Xiongwei Zhu; Mark A. Smith; George Perry; Gjumrakch Aliev
Mitochondrial failures in Alzheimer's disease.
American journal of Alzheimer's disease and other dementias 2004;19(6):345-52.
2004: Hyoung-gon Lee; Paula I Moreira; Xiongwei Zhu; Mark A. Smith; George Perry
Staying connected: synapses in Alzheimer disease.
The American journal of pathology 2004;165(5):1461-4.
2004: Gemma Casadesus Smith; Barbara Shukitt-Hale; Heather M Stellwagen; Xiongwei Zhu; Hyoung-gon Lee; Mark A. Smith; James A Joseph
Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats.
Nutritional neuroscience 2004;7(5-6):309-16.
2004: Atsushi Takeda; Yasuto Itoyama; Teiko Kimpara; Xiongwei Zhu; Jesús Avila; Barney E Dwyer; George Perry; Mark A. Smith
Heme catabolism and heme oxygenase in neurodegenerative disease.
Antioxidants & redox signaling 2004;6(5):888-94.
2004: Yi Long Ma; Margaret E Rice; Mei Lan Chao; Patricia M Rivera; Huiwen W Zhao; Austin P Ross; Xiongwei Zhu; Mark A. Smith; Kelly L Drew
Ascorbate distribution during hibernation is independent of ascorbate redox state.
Free radical biology & medicine 2004;37(4):511-20.
2004: Gemma Casadesus Smith; Xiongwei Zhu; Craig S Atwood; Kate M Webber; George Perry; Richard L Bowen; Mark A. Smith
Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease.
Current drug targets. CNS and neurological disorders 2004;3(4):281-5.
2004: Kelly L Drew; Michael Harris; Joseph C LaManna; Mark A. Smith; Xiongwei Zhu; Yi Long Ma
Hypoxia tolerance in mammalian heterotherms.
The Journal of experimental biology 2004;207(Pt 18):3155-62.
2004: Xiongwei Zhu; Kate M Webber; Gemma Casadesus Smith; Arun K Raina; Hyoung-gon Lee; Michael W Marlatt; Anthony W Hartzler; Craig S Atwood; George Perry; Mark A. Smith
Mitotic and gender parallels in Alzheimer disease: therapeutic opportunities.
Current drug targets 2004;5(6):559-63.
2004: Rudy J Castellani; Kazuhiro Honda; Xiongwei Zhu; Adam D Cash; Akihiko Nunomura; George Perry; Mark A. Smith
Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease.
Ageing research reviews 2004;3(3):319-26.
2004: Hyoung-gon Lee; Gemma Casadesus Smith; Xiongwei Zhu; Atsushi Takeda; George Perry; Mark A. Smith
Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease.
Annals of the New York Academy of Sciences 2004;1019():1-4.
2004: Xiongwei Zhu; Yang Wang; Osamu Ogawa; Hyoung-gon Lee; Arun K Raina; Sandra L Siedlak; Peggy L R Harris; Hisashi Fujioka; Shun Shimohama; Massimo Tabaton; Craig S Atwood; Robert B Petersen; George Perry; Mark A. Smith
Neuroprotective properties of Bcl-w in Alzheimer disease.
Journal of neurochemistry 2004;89(5):1233-40.
2004: Gemma Casadesus Smith; Mark A. Smith; Xiongwei Zhu; Gjumrakch Aliev; Adam D Cash; Kazuhiro Honda; Robert B Petersen; George Perry
Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species.
Journal of Alzheimer's disease : JAD 2004;6(2):165-9.
2004: Hyoung-gon Lee; Gemma Casadesus Smith; Xiongwei Zhu; James A Joseph; George Perry; Mark A. Smith
Perspectives on the amyloid-beta cascade hypothesis.
Journal of Alzheimer's disease : JAD 2004;6(2):137-45.
2004: Xiongwei Zhu; Arun K Raina; George Perry; Mark A. Smith
Alzheimer's disease: the two-hit hypothesis.
Lancet neurology 2004;3(4):219-26.
2004: Hyoung-gon Lee; Osamu Ogawa; Xiongwei Zhu; Michael J O'Neill; Robert B Petersen; Rudy J Castellani; Hossein A Ghanbari; George Perry; Mark A. Smith
Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease.
Acta neuropathologica 2004;107(4):365-71.
2004: Xiongwei Zhu; Arun K Raina; Hyoung-gon Lee; Gemma Casadesus Smith; Mark A. Smith; George Perry
Oxidative stress signalling in Alzheimer's disease.
Brain research 2004;1000(1-2):32-9.
2004: Xiongwei Zhu; Andy McShea; Peggy L R Harris; Arun K Raina; Rudy J Castellani; Jens Oliver Funk; Sapan Shah; Craig S Atwood; Richard Bowen; Robert Bowser; Laura Morelli; George Perry; Mark A. Smith
Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease.
Journal of neuroscience research 2004;75(5):698-703.
2004: Arun K Raina; Xiongwei Zhu; Mark A. Smith
Alzheimer's disease and the cell cycle.
Acta neurobiologiae experimentalis 2004;64(1):107-12.
2004: Hyoung-gon Lee; Xiongwei Zhu; Michael J O'Neill; Kate M Webber; Gemma Casadesus Smith; Michael W Marlatt; Arun K Raina; George Perry; Mark A. Smith
The role of metabotropic glutamate receptors in Alzheimer's disease.
Acta neurobiologiae experimentalis 2004;64(1):89-98.
2004: Michael W Marlatt; Hyoung-gon Lee; George Perry; Mark A. Smith; Xiongwei Zhu
Sources and mechanisms of cytoplasmic oxidative damage in Alzheimer's disease.
Acta neurobiologiae experimentalis 2004;64(1):81-7.
2003: Hyoung-gon Lee; Robert B Petersen; Xiongwei Zhu; Kazuhiro Honda; Gjumrakch Aliev; Mark A. Smith; George Perry
Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases?
Brain pathology (Zurich, Switzerland) 2003;13(4):630-8.
2003: Xiongwei Zhu; Arun K Raina; Hyoung-gon Lee; Mark Chao; Akihiko Nunomura; Massimo Tabaton; Robert B Petersen; George Perry; Mark A. Smith
Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways.
Antioxidants & redox signaling 2003;5(5):571-6.
2003: Xiongwei Zhu; Zheng Sun; Hyoung-gon Lee; Sandra L Siedlak; George Perry; Mark A. Smith
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Journal of neurochemistry 2003;86(1):136-42.
2003: Adam D Cash; Gjumrakch Aliev; Sandra L Siedlak; Akihiko Nunomura; Hisashi Fujioka; Xiongwei Zhu; Arun K Raina; Harry V Vinters; Massimo Tabaton; Anne B Johnson; Manuel M Paula-Barbosa; Jesus Avíla; Paul K Jones; Rudy J Castellani; Mark A. Smith; George Perry
Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.
The American journal of pathology 2003;162(5):1623-7.
2003: Osamu Ogawa; Xiongwei Zhu; Hyoung-gon Lee; Arun K Raina; Mark E Obrenovich; Robert Bowser; Hossein A Ghanbari; Rudy J Castellani; George Perry; Mark A. Smith
Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?
Acta neuropathologica 2003;105(5):524-8.
2003: Osamu Ogawa; Hyoung-gon Lee; Xiongwei Zhu; Arun K Raina; Peggy L R Harris; Rudy J Castellani; George Perry; Mark A. Smith
Increased p27, an essential component of cell cycle control, in Alzheimer's disease.
Aging cell 2003;2(2):105-10.
2003: Arun K Raina; Ayala Hochman; Harold Ickes; Xiongwei Zhu; Osamu Ogawa; Adam D Cash; Shun Shimohama; George Perry; Mark A. Smith
Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?
Progress in neuro-psychopharmacology & biological psychiatry 2003;27(2):251-4.
2003: Xiongwei Zhu; Osamu Ogawa; Yang Wang; George Perry; Mark A. Smith
JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease.
Journal of neurochemistry 2003;85(1):87-93.
2003: Arun K Raina; Xiongwei Zhu; Shun Shimohama; George Perry; Mark A. Smith
Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept.
Cell biochemistry and biophysics 2003;39(3):249-55.
2003: Xiongwei Zhu; George Perry; Mark A. Smith
Amyotrophic lateral sclerosis: a novel hypothesis involving a gained 'loss of function' in the JNK/SAPK pathway.
Redox report : communications in free radical research 2003;8(3):129-33.
2002: George Perry; Marta A Taddeo; Akihiko Nunomura; Xiongwei Zhu; Tania Zenteno-Savin; Kelly L Drew; Shun Shimohama; Jesús Avila; Rudy J Castellani; Mark A. Smith
Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2002;133(4):507-13.
2002: George Perry; Akihiko Nunomura; Keisuke Hirai; Xiongwei Zhu; Mar Pérez; Jesús Avila; Rudy J Castellani; Craig S Atwood; Gjumrakch Aliev; Lawrence M Sayre; Atsushi Takeda; Mark A. Smith
Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?
Free radical biology & medicine 2002;33(11):1475-9.
2002: Osamu Ogawa; Xiongwei Zhu; George Perry; Mark A. Smith
Mitochondrial abnormalities and oxidative imbalance in neurodegenerative disease.
Science of aging knowledge environment : SAGE KE 2002;2002(41):pe16.
2002: Adam D Cash; George Perry; Osamu Ogawa; Arun K Raina; Xiongwei Zhu; Mark A. Smith
Is Alzheimer's disease a mitochondrial disorder?
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2002;8(5):489-96.
2002: Fang Zhou; Joan F Braddock; Yong Hu; Xiongwei Zhu; Rudy J Castellani; Mark A. Smith; Kelly L Drew
Microbial origin of glutamate, hibernation and tissue trauma: an in vivo microdialysis study.
Journal of neuroscience methods 2002;119(2):121-8.
2002: Hyoung-gon Lee; Xiongwei Zhu; Hossein A Ghanbari; Osamu Ogawa; Arun K Raina; Micheal J O'Neill; George Perry; Mark A. Smith
Differential regulation of glutamate receptors in Alzheimer's disease.
Neuro-Signals 2002;11(5):282-92.
2002: Xiongwei Zhu; Hyoung-gon Lee; Arun K Raina; George Perry; Mark A. Smith
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Neuro-Signals 2002;11(5):270-81.
2002: Anthony W Hartzler; Xiongwei Zhu; Sandra L Siedlak; Rudy J Castellani; Jesús Avila; George Perry; Mark A. Smith
The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.
Neurobiology of aging 2002;23(5):855-9.
2002: Mark A. Smith; Kelly L Drew; Akihiko Nunomura; Atsushi Takeda; Keisuke Hirai; Xiongwei Zhu; Craig S Atwood; Arun K Raina; Catherine A Rottkamp; Lawrence M Sayre; Robert P Friedland; George Perry
Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?
Neurochemistry international 2002;40(6):527-31.
2002: Kimberly L Clapp-Lilly; Mark A. Smith; George Perry; Peggy L Harris; Xiongwei Zhu; Kelly L Drew; Lawrence K Duffy
Melatonin exhibits antioxidant properties in a mouse brain slice model of excitotoxicity.
International journal of circumpolar health 2002;61(1):32-40.
2001: Xiongwei Zhu; Rudy J Castellani; Atsushi Takeda; Akihiko Nunomura; Craig S Atwood; George Perry; Mark A. Smith
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Mechanisms of ageing and development 2001;123(1):39-46.
2001: Arun K Raina; P Pardo; Catherine A Rottkamp; Xiongwei Zhu; Olivia M Pereira-Smith; Mark A. Smith
Neurons in Alzheimer disease emerge from senescence.
Mechanisms of ageing and development 2001;123(1):3-9.
2001: Xiongwei Zhu; Catherine A Rottkamp; Anthony W Hartzler; Zheng Sun; Atsushi Takeda; H Boux; Shun Shimohama; George Perry; Mark A. Smith
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.
Journal of neurochemistry 2001;79(2):311-8.
2001: F Zhou; Xiongwei Zhu; Rudy J Castellani; R Stimmelmayr; George Perry; Mark A. Smith; Kelly L Drew
Hibernation, a model of neuroprotection.
The American journal of pathology 2001;158(6):2145-51.
2001: Kimberly L Clapp-Lilly; Mark A. Smith; George Perry; P L Harris; Xiongwei Zhu; Lawrence K Duffy
Melatonin acts as antioxidant and pro-oxidant in an organotypic slice culture model of Alzheimer's disease.
Neuroreport 2001;12(6):1277-80.
2001: Arun K Raina; A Hochman; Xiongwei Zhu; Catherine A Rottkamp; Akihiko Nunomura; Sandra L Siedlak; H Boux; Rudy J Castellani; George Perry; Mark A. Smith
Abortive apoptosis in Alzheimer's disease.
Acta neuropathologica 2001;101(4):305-10.
2001: Catherine A Rottkamp; Arun K Raina; Xiongwei Zhu; E Gaier; Ashley I Bush; Craig S Atwood; M Chevion; George Perry; Mark A. Smith
Redox-active iron mediates amyloid-beta toxicity.
Free radical biology & medicine 2001;30(4):447-50.
2001: Xiongwei Zhu; Arun K Raina; Catherine A Rottkamp; Gjumrakch Aliev; George Perry; H Boux; Mark A. Smith
Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.
Journal of neurochemistry 2001;76(2):435-41.
2001: George Perry; Xiongwei Zhu; Mark A. Smith
Do neurons have a choice in death?
The American journal of pathology 2001;158(1):1-2.
2000: Peggy L R Harris; Xiongwei Zhu; C Pamies; Catherine A Rottkamp; Hossein A Ghanbari; Andy McShea; Y Feng; D K Ferris; Mark A. Smith
Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes.
Neurobiology of aging 2000;21(6):837-41.
2000: Xiongwei Zhu; Catherine A Rottkamp; Arun K Raina; Gregory J Brewer; Hossein A Ghanbari; H Boux; Mark A. Smith
Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease.
Neurobiology of aging 2000;21(6):807-13.
2000: Xiongwei Zhu; Catherine A Rottkamp; H Boux; Atsushi Takeda; George Perry; Mark A. Smith
Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease.
Journal of neuropathology and experimental neurology 2000;59(10):880-8.
2000: Atsushi Takeda; Mark A. Smith; Jesús Avila; Akihiko Nunomura; Sandra L Siedlak; Xiongwei Zhu; George Perry; Lawrence M Sayre
In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.
Journal of neurochemistry 2000;75(3):1234-41.
2000: Arun K Raina; Xiongwei Zhu; Catherine A Rottkamp; Mervyn Monteiro; Atsushi Takeda; Mark A. Smith
Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease.
Journal of neuroscience research 2000;61(2):128-33.
2000: Xiongwei Zhu; Arun K Raina; H Boux; Z L Simmons; Atsushi Takeda; Mark A. Smith
Activation of oncogenic pathways in degenerating neurons in Alzheimer disease.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2000;18(4-5):433-7.
2000: H T Kim; RL Russell; Arun K Raina; Peggy L R Harris; Sandra L Siedlak; Xiongwei Zhu; Robert B Petersen; Shun Shimohama; Mark A. Smith; George Perry
Protein disulfide isomerase in Alzheimer disease.
Antioxidants & redox signaling 2000;2(3):485-9.
2000: Mark A. Smith; Akihiko Nunomura; Xiongwei Zhu; Atsushi Takeda; George Perry
Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease.
Antioxidants & redox signaling 2000;2(3):413-20.
2000: Arun K Raina; Xiongwei Zhu; Mervyn Monteiro; Atsushi Takeda; Mark A. Smith
Abortive oncogeny and cell cycle-mediated events in Alzheimer disease.
Progress in cell cycle research 2000;4():235-42.
1999: George Perry; H Roder; Akihiko Nunomura; Atsushi Takeda; Avi Friedlich; Xiongwei Zhu; Arun K Raina; N Holbrook; Sandra L Siedlak; P L Harris; Mark A. Smith
Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.
Neuroreport 1999;10(11):2411-5.
1999: Xiongwei Zhu; Arun K Raina; Mark A. Smith
Cell cycle events in neurons. Proliferation or death?
The American journal of pathology 1999;155(2):327-9.