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Richard Brochu

Research Profile

Chemicals & Drugs

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Electrophysiology

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Anatomy

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TOP 3
S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl pyrazoles as sodium channel blockers.

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All Publications

2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Bioorganic & medicinal chemistry letters 2010;20(24):7479-82.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5536-40.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl pyrazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5480-3.
2007: Brande S Williams; John P Felix; Birgit T Priest; Richard Brochu; Kefei Dai; Scott B Hoyt; Clare London; Yui S Tang; Joseph L Duffy; William H Parsons; Gregory J Kaczorowski; Maria L Garcia
Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.
Biochemistry 2007;46(50):14693-703.
2007: Ivy E Dick; Richard Brochu; Yamini Purohit; Gregory J Kaczorowski; William J Martin; Birgit T Priest
Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.
The journal of pain : official journal of the American Pain Society 2007;8(4):315-24.
2006: Richard Brochu; Ivy E Dick; Jason W Tarpley; Erin McGowan; David Gunner; James Herrington; Pengcheng P Shao; Dong Ok; Chunshi Li; William H Parsons; Gary L Stump; christopher regan; Joseph J Lynch; Kathryn A Lyons; Owen B McManus; Samantha Clark; Zahid Ali; Gregory J Kaczorowski; William J Martin; Birgit T Priest
Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.
Molecular pharmacology 2006;69(3):823-32.
2006: Chou J Liu; Birgit T Priest; Randal M Bugianesi; Paula M Dulski; John P Felix; Ivy E Dick; Richard Brochu; Hans-Günther Knaus; Richard E Middleton; Gregory J Kaczorowski; Robert S Slaughter; Maria L Garcia; Martin G Köhler
A high-capacity membrane potential FRET-based assay for NaV1.8 channels.
Assay and drug development technologies 2006;4(1):37-48.
2005: James Herrington; Manuel Sanchez; Denise Wunderler; Lizhen Yan; Randal M Bugianesi; Ivy E Dick; Sam A Clark; Richard Brochu; Birgit T Priest; Martin G Kohler; Owen B McManus
Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells.
The Journal of physiology 2005;567(Pt 1):159-75.
2005: Jun Liang; Richard Brochu; charles cohen; Ivy E Dick; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; Peter T Meinke; Birgit T Priest; william Schmalhofer; McHardy Smith; Jason W Tarpley; Brande S Williams; William J Martin; William H Parsons
Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(11):2943-7.
2005: Lizhen Yan; James Herrington; Ethan Goldberg; Paula M Dulski; Randal M Bugianesi; Robert S Slaughter; Priya Banerjee; Richard Brochu; Birgit T Priest; Gregory J Kaczorowski; Bernardo Rudy; Maria L Garcia
Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels.
Molecular pharmacology 2005;67(5):1513-21.
2004: Birgit T Priest; Maria L Garcia; Richard E Middleton; Richard Brochu; Samantha Clark; Ge Dai; Ivy E Dick; John P Felix; Chou J Liu; Brita S Reiseter; william Schmalhofer; Pengcheng P Shao; Yui S Tang; Margaret Z Chou; Martin G Kohler; McHardy Smith; Vivien A Warren; Brande S Williams; charles cohen; William J Martin; Peter T Meinke; William H Parsons; Keith A Wafford; Gregory J Kaczorowski
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.
Biochemistry 2004;43(30):9866-76.
2004: John P Felix; Brande S Williams; Birgit T Priest; Richard Brochu; Ivy E Dick; Vivien A Warren; Lizhen Yan; Robert S Slaughter; Gregory J Kaczorowski; McHardy Smith; Maria L Garcia
Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.
Assay and drug development technologies 2004;2(3):260-8.
2002: Richard E Middleton; Vivien A Warren; Richard L Kraus; Jeremy C Hwang; Chou J Liu; Ge Dai; Richard Brochu; Martin G Kohler; Ying-Duo Gao; Victor M Garsky; Michael J Bogusky; John T Mehl; charles cohen; McHardy Smith
Two tarantula peptides inhibit activation of multiple sodium channels.
Biochemistry 2002;41(50):14734-47.
2000: N S Kane; B Hirschberg; S Qian; D Hunt; B Thomas; Richard Brochu; Steven W Ludmerer; Yingcong Zheng; McHardy Smith; JP Arena; charles cohen; Dennis M Schmatz; JW Warmke; Doris F Cully
Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13949-54.
2000: McHardy Smith; Vivien A Warren; B S Thomas; Richard Brochu; E A Ertel; S Rohrer; J Schaeffer; Dennis M Schmatz; B R Petuch; Yui S Tang; Peter T Meinke; Gregory J Kaczorowski; charles cohen
Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator.
Biochemistry 2000;39(18):5543-54.
1999: siegmund wanner; Hartmut Glossmann; Hans-Günther Knaus; R Baker; William H Parsons; Kathleen M Rupprecht; Richard Brochu; charles cohen; william Schmalhofer; McHardy Smith; Vivien A Warren; Maria L Garcia; Gregory J Kaczorowski
WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels.
Biochemistry 1999;38(34):11137-46.
1994: John R Clay; A S Kristof; J Shenasa; Richard Brochu; Alvin Shrier
A review of the effects of three cardioactive agents on the electrical activity from embryonic chick heart cell aggregates: TTX, ACh, and E-4031.
Progress in biophysics and molecular biology 1994;62(3):185-202.
1992: Richard Brochu; John R Clay; Alvin Shrier
Pacemaker current in single cells and in aggregates of cells dissociated from the embryonic chick heart.
The Journal of physiology 1992;454():503-15.
1990: Z Wanzhen; J Morissette; Richard Brochu; L Glass; Alvin Shrier
NASPE young investigator awardee-1990. Complex rhythms resulting from overdrive suppression in electrically stimulated heart cell aggregates.
Pacing and clinical electrophysiology : PACE 1990;13(12 Pt 1):1678-85.
1990: Alvin Shrier; John R Clay; Richard Brochu
Effects of tetrodotoxin on heart cell aggregates. Phase resetting and annihilation of activity.
Biophysical journal 1990;58(3):623-9.
1990: John R Clay; Richard Brochu; Alvin Shrier
Phase resetting of embryonic chick atrial heart cell aggregates. Experiment and theory.
Biophysical journal 1990;58(3):609-21.
1986: M B Bacaner; John R Clay; Alvin Shrier; Richard Brochu
Potassium channel blockade: A mechanism for suppressing ventricular fibrillation.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(7):2223-7.