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Roger Gunn

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Cristian Salinas; Graham Searle; David Weinzimmer; Richard E Carson; Yiyun Huang; David Labaree; Eugenii A Rabiner; Jim Ropchan; Roger Gunn
Kinetic analysis of drug-target interactions with PET for characterization of pharmacological hysteresis.
Graham E Searle; Andri Tziortzi; Marc Laruelle; Emilio Merlo Pich; Eugenii A Rabiner; Massimo Bani; John D Beaver; Robert A Comley; Giulia Ghibellini; Roger Gunn
Mathematical modelling of [¹¹C]-(+)-PHNO human competition studies.
David M Cole; Roger Gunn; Paul M Matthews; Thomas E Nichols; Christophe Plisson; Eugenii A Rabiner; Graham E Searle; Andri C Tziortzi; Christian F Beckmann; John D Beaver
Orbitofrontal connectivity with resting-state networks is associated with midbrain dopamine D3 receptor availability.

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2013: Cristian Salinas; Graham Searle; David Weinzimmer; Richard E Carson; Yiyun Huang; David Labaree; Eugenii A Rabiner; Jim Ropchan; Roger Gunn
Kinetic analysis of drug-target interactions with PET for characterization of pharmacological hysteresis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2013;33(5):700-7.
2013: Graham E Searle; Andri Tziortzi; Marc Laruelle; Emilio Merlo Pich; Eugenii A Rabiner; Massimo Bani; John D Beaver; Robert A Comley; Giulia Ghibellini; Roger Gunn
Mathematical modelling of [¹¹C]-(+)-PHNO human competition studies.
NeuroImage 2013;68():119-32.
2012: David M Cole; Roger Gunn; Paul M Matthews; Thomas E Nichols; Christophe Plisson; Eugenii A Rabiner; Graham E Searle; Andri C Tziortzi; Christian F Beckmann; John D Beaver
Orbitofrontal connectivity with resting-state networks is associated with midbrain dopamine D3 receptor availability.
Cerebral cortex (New York, N.Y. : 1991) 2012;22(12):2784-93.
2012: Jean-Dominique Gallezot; Roger Gunn; Yiyun Huang; Marc Laruelle; Nabeel Nabulsi; John D Beaver; Richard E Carson; Yu-Shin Ding; Krista Fowles; Tarun Singhal; Mark Slifstein; David Weinzimmer; Eugenii A Rabiner
Affinity and selectivity of [¹¹C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo.
Synapse (New York, N.Y.) 2012;66(6):489-500.
2012: Qi Guo; David R Owen; Eugenii A Rabiner; Federico E Turkheimer; Roger Gunn
Identifying improved TSPO PET imaging probes through biomathematics: the impact of multiple TSPO binding sites in vivo.
NeuroImage 2012;60(2):902-10.
2012: Christine A Parker; Eugenii A Rabiner; Cristian Salinas; Mark Slifstein; Robert Comley; Vincent J Cunningham; Roger Gunn; Sylvain Houle; Steen Jakobsen; Christopher N Johnson; Marc Laruelle; Laurent Martarello
Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012;53(2):295-303.
2012: Stefano Zamuner; Massimo Bani; Sofia A Fernandes; Roberto Gomeni; Roger Gunn; Eugenii A Rabiner; Emilangelo Ratti; Vincent J Cunningham
A pharmacokinetic PET study of NK₁ receptor occupancy.
European journal of nuclear medicine and molecular imaging 2012;39(2):226-35.
2012: Paul M Matthews; Jan Passchier; Eugenii A Rabiner; Roger Gunn
Positron emission tomography molecular imaging for drug development.
British journal of clinical pharmacology 2012;73(2):175-86.
2012: David R Owen; Andrew Lewis; Idriss Bennacef; Roger Gunn; Lon R Cardon; Eugenii A Rabiner; David J Pulford; Paul M Matthews; Pamela L StJean; Astrid J Yeo; Graham Wadsworth; Kijoung Song; Vincent E Mooser; Christine A Parker; Chris Rhodes; Justin P Rubio
An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(1):1-5.
2012: Paul Shotbolt; Marc Laruelle; Graham E Searle; Sergio Abanades; Mickael Huiban; John D Beaver; Alessandro Colasanti; Christophe Plisson; Andri C Tziortzi; Jasper van der Aart; Sam R Miller; Roger Gunn; Eugenii A Rabiner
Within-subject comparison of [(11)C]-(+)-PHNO and [(11)C]raclopride sensitivity to acute amphetamine challenge in healthy humans.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(1):127-36.
2011: Roger Gunn; Raul Herance; Santiago Bullich; Ana M Catafau; Magi Farre; Venkatesha Murthy; Daniele Ouellet; Ricardo Pardo-Lozano; Eugenii A Rabiner; Cristian Salinas; Graham Searle; Mark Slifstein; Stefano Zamuner; Marc Laruelle
Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1.
Synapse (New York, N.Y.) 2011;65(12):1319-32.
2011: Khanum Ridler; Anissa Abi-Dargham; Balu Easwaramoorthy; Roger Gunn; Marc Laruelle; Christophe Plisson; Eugenii A Rabiner; Mark Slifstein
Characterization of in vivo pharmacological properties and sensitivity to endogenous serotonin of [11C] P943: a positron emission tomography study in Papio anubis.
Synapse (New York, N.Y.) 2011;65(11):1119-27.
2011: Christophe Plisson; Cristian Salinas; Paul W Smith; David Weinzimmer; Richard E Carson; Yu-Shin Ding; Kawanishi Eiji; Roger Gunn; Steen Jakobsen; David Labaree; Shu-Fei Lin; Eugenii A Rabiner
Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A.
Nuclear medicine and biology 2011;38(6):875-84.
2011: E A Rabiner; R Reiley; G Searle; J Beaver; M A Bush; Roger Gunn; S Hill; J Howard; C Long; A Makwana; P M Matthews; S R Miller; P J Nathan; R D Newbould; J Passchier; E T Bullmore
Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans.
Molecular psychiatry 2011;16(8):826-35, 785.
2011: Santiago Bullich; Magí Farré; Gispert Juan; Roger Gunn; Antonio Gutiérrez; Raul Herance; Lawrence S Kegeles; Jong-Hoon Kim; Marc Laruelle; N Venkatesha Murthy; Jan Passchier; Mark Slifstein; Xiaoyan Xu; Ana M Catafau
Biodistribution and radiation dosimetry of the glycine transporter-1 ligand 11C-GSK931145 determined from primate and human whole-body PET.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2011;13(4):776-84.
2011: Ragy R Girgis; Xiaoyan Xu; Nobumi Miyake; Balu Easwaramoorthy; Roger Gunn; Eugenii A Rabiner; Anissa Abi-Dargham; Mark Slifstein
In vivo binding of antipsychotics to D3 and D2 receptors: a PET study in baboons with [11C]-(+)-PHNO.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(4):887-95.
2011: Sergio Abanades; Jasper van der Aart; Julien A R Barletta; Carmine Marzano; Graham E Searle; Cristian A Salinas; Javaad J Ahmad; Richard R Reiley; Sabina Pampols-Maso; Stefano Zamuner; Vincent J Cunningham; Eugenii A Rabiner; Marc A Laruelle; Roger Gunn
Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(3):944-52.
2011: Victor W Pike; Isabella Pugliesi; Eugenii A Rabiner; Sabrina Taliani; Sami S Zoghbi; Eleonora Da Pozzo; Masahiro Fujita; Roger Gunn; Jinsoo Hong; Robert B Innis; Talakad G Lohith; Claudia Martini; David R J Owen; Christine A Parker; Federico Da Settimo
Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands.
Journal of medicinal chemistry 2011;54(1):366-73.
2011: David R J Owen; Roger Gunn; Eugenii A Rabiner; Idriss Bennacef; Masahiro Fujita; William C Kreisl; Robert B Innis; Victor W Pike; Richard Reynolds; Paul M Matthews; Christine A Parker
Mixed-affinity binding in humans with 18-kDa translocator protein ligands.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(1):24-32.
2011: Andri C Tziortzi; Graham E Searle; Sofia Tzimopoulou; Cristian Salinas; John D Beaver; Mark Jenkinson; Marc Laruelle; Eugenii A Rabiner; Roger Gunn
Imaging dopamine receptors in humans with [11C]-(+)-PHNO: dissection of D3 signal and anatomy.
NeuroImage 2011;54(1):264-77.
2010: Davangere P Devanand; Arthur Mikhno; Gregory H Pelton; Katrina Cuasay; Gnanavalli Pradhaban; J S Dileep Kumar; Neil Upton; Robert Lai; Roger Gunn; V Libri; Xinhua Liu; Ronald van Heertum; J John Mann; Ramin V Parsey
Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls.
Journal of geriatric psychiatry and neurology 2010;23(3):185-98.
2010: David R Owen; Owain W Howell; Sac-Pham Tang; Lisa A Wells; Idriss Bennacef; Mats Bergstrom; Roger Gunn; Eugenii A Rabiner; Martin R Wilkins; Richard Reynolds; Paul Matthews; Christine A Parker
Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(9):1608-18.
2010: Jingyi Xie; Stuart Clare; Daniel Gallichan; Roger Gunn; Peter Jezzard
Real-time adaptive sequential design for optimal acquisition of arterial spin labeling MRI data.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2010;64(1):203-10.
2010: Sharon Ashworth; Eugenii A Rabiner; Roger Gunn; Christophe Plisson; Alan Wilson; Robert A Comley; Robert Y K Lai; Antony D Gee; Marc Laruelle; Vincent J Cunningham
Evaluation of 11C-GSK189254 as a novel radioligand for the H3 receptor in humans using PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(7):1021-9.
2010: J Passchier; G Gentile; R Porter; H Herdon; C Salinas; S Jakobsen; H Audrain; Marc Laruelle; Roger Gunn
Identification and evaluation of [11C]GSK931145 as a novel ligand for imaging the type 1 glycine transporter with positron emission tomography.
Synapse (New York, N.Y.) 2010;64(7):542-9.
2010: S Zamuner; V L Di Iorio; J Nyberg; Roger Gunn; V J Cunningham; R Gomeni; A C Hooker
Adaptive-optimal design in PET occupancy studies.
Clinical pharmacology and therapeutics 2010;87(5):563-71.
2010: S Bullich; A Cot; J Gallego; Roger Gunn; M Suárez; J Pavía; D Ros; M Laruelle; A M Catafau
Impact of scatter correction on D2 receptor occupancy measurements using 123I-IBZM SPECT: comparison to 11C-Raclopride PET.
NeuroImage 2010;50(4):1511-8.
2010: Ana M Catafau; Graham E Searle; Santiago Bullich; Roger Gunn; Eugenii A Rabiner; Raul Herance; Joaquim Radua; Magi Farre; Marc Laruelle
Imaging cortical dopamine D1 receptors using [11C]NNC112 and ketanserin blockade of the 5-HT 2A receptors.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(5):985-93.
2010: Vincent J Cunningham; Eugenii A Rabiner; Mark Slifstein; Marc Laruelle; Roger Gunn
Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(1):46-50.
2009: Christophe Plisson; Roger Gunn; Vincent J Cunningham; Dirk Bender; Cristian A Salinas; Andrew D Medhurst; Jennifer C Roberts; Marc Laruelle; Antony D Gee
11C-GSK189254: a selective radioligand for in vivo central nervous system imaging of histamine H3 receptors by PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(12):2064-72.
2009: Qi Guo; Michael Brady; Roger Gunn
A biomathematical modeling approach to central nervous system radioligand discovery and development.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(10):1715-23.
2009: Idriss Bennacef; Cristian A Salinas; Thomas A Bonasera; Roger Gunn; Hélène Audrain; Steen Jakobsen; Nabeel Nabulsi; David Weinzimmer; Richard E Carson; Yiyun Huang; Ian Holmes; Fabrizio Micheli; Christian Heidbreder; Gabriella Gentile; Tino Rossi; Marc Laruelle
Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies.
Bioorganic & medicinal chemistry letters 2009;19(17):5056-9.
2009: Eugenii A Rabiner; Mark Slifstein; Jose Nobrega; Christophe Plisson; Mickael Huiban; Roger Raymond; Mustansir Diwan; Alan Wilson; Patrick McCormick; Gabriella Gentile; Roger Gunn; Marc Laruelle
In vivo quantification of regional dopamine-D3 receptor binding potential of (+)-PHNO: Studies in non-human primates and transgenic mice.
Synapse (New York, N.Y.) 2009;63(9):782-93.
2009: Lisbeth Marner; Nic Gillings; Robert A Comley; William F C Baaré; Eugenii A Rabiner; Alan Wilson; Sylvain Houle; Steen G Hasselbalch; Claus Svarer; Roger Gunn; Marc Laruelle; Gitte Moos Knudsen
Kinetic modeling of 11C-SB207145 binding to 5-HT4 receptors in the human brain in vivo.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(6):900-8.
2009: Ana M Catafau; Marina Suarez; Santiago Bullich; Jordi Llop; Gianluca Nucci; Roger Gunn; Claire Brittain; Marc Laruelle
Within-subject comparison of striatal D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride PET.
NeuroImage 2009;46(2):447-58.
2009: Rajesh Narendran; W Gordon Frankle; N Scott Mason; Eugenii A Rabiner; Roger Gunn; Graham E Searle; Shivangi Vora; Maralee Litschge; Steve Kendro; Thomas B Cooper; Chester A Mathis; Marc Laruelle
Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride.
Synapse (New York, N.Y.) 2009;63(6):447-61.
2008: S G Summerfield; A J Lucas; R A Porter; P Jeffrey; Roger Gunn; K R Read; A J Stevens; A C Metcalf; M C Osuna; P J Kilford; J Passchier; A D Ruffo
Toward an improved prediction of human in vivo brain penetration.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(12):1518-35.
2008: Jyh-Ying Peng; John A D Aston; Roger Gunn; Cheng-Yuan Liou; John Ashburner
Dynamic positron emission tomography data-driven analysis using sparse Bayesian learning.
IEEE transactions on medical imaging 2008;27(9):1356-69.
2008: Jingyi Xie; Daniel Gallichan; Roger Gunn; Peter Jezzard
Optimal design of pulsed arterial spin labeling MRI experiments.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(4):826-34.
2007: Robert B Innis; Vincent J Cunningham; Jacques Delforge; Masahiro Fujita; Albert Gjedde; Roger Gunn; James Holden; Sylvain Houle; Sung-Cheng Huang; Masanori Ichise; Hidehiro Iida; Hiroshi Ito; Yuichi Kimura; Robert A Koeppe; Gitte Moos Knudsen; Juhani Knuuti; Adriaan A Lammertsma; Marc Laruelle; Jean Logan; Ralph Paul Maguire; Mark A Mintun; Evan D Morris; Ramin V Parsey; Julie C Price; Mark Slifstein; Vesna Sossi; Tetsuya Suhara; John R Votaw; Dean F Wong; Richard E Carson
Consensus nomenclature for in vivo imaging of reversibly binding radioligands.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(9):1533-9.
2006: Isabelle Boileau; Alain Dagher; Marco Leyton; Roger Gunn; Glen B Baker; Mirko Diksic; Chawki Benkelfat
Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men.
Archives of general psychiatry 2006;63(12):1386-95.
2006: W Gordon Frankle; Mark Slifstein; Roger Gunn; Yiyun Huang; Dah-Ren Hwang; E Ashlie Darr; Rajesh Narendran; Anissa Abi-Dargham; Marc Laruelle
Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(5):815-26.
2005: Paula Wells; Roger Gunn; Colin Steel; Alex S Ranicar; Frank Brady; Safiye Osman; Terry Jones; Pat Price
2-[11C]thymidine positron emission tomography reproducibility in humans.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(12):4341-7.
2005: Christine A Parker; Julian C Matthews; Roger Gunn; Laurent Martarello; Vincent J Cunningham; David Dommett; Stephen T Knibb; Dirk Bender; Steen Jakobsen; John Brown; Antony D Gee
Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4.
Synapse (New York, N.Y.) 2005;55(4):270-9.
2005: Christian-G Bénar; Roger Gunn; Christophe Grova; Benoît Champagne; Jean Gotman
Statistical maps for EEG dipolar source localization.
IEEE transactions on bio-medical engineering 2005;52(3):401-13.
2005: John A D Aston; Roger Gunn; Rainer Hinz; Federico E Turkheimer
Wavelet variance components in image space for spatiotemporal neuroimaging data.
NeuroImage 2005;25(1):159-68.
2004: Eugenii A Rabiner; Zubin Bhagwagar; Roger Gunn; Philip J Cowen; Paul M Grasby
Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression?
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(9):1688-98.
2004: V J Cunningham; Roger Gunn; Julian C Matthews
Quantification in positron emission tomography for research in pharmacology and drug development.
Nuclear medicine communications 2004;25(7):643-6.
2004: Marie-Claude Asselin; Vincent J Cunningham; Shigeko Amano; Roger Gunn; Claude Nahmias
Parametrically defined cerebral blood vessels as non-invasive blood input functions for brain PET studies.
Physics in medicine and biology 2004;49(6):1033-54.
2004: Sunil L Kukreja; Roger Gunn
Bootstrapped DEPICT for error estimation in PET functional imaging.
NeuroImage 2004;21(3):1096-104.
2004: Rodrigo A Bressan; Kjell Erlandsson; Rachel S Mulligan; Roger Gunn; Vincent J Cunningham; Jonathan Owens; Ian D Cullum; Peter J Ell; Lyn S Pilowsky
A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [123I]CNS 1261.
Nuclear medicine and biology 2004;31(2):155-64.
2004: Guoming Xie; Roger Gunn; Alain Dagher; Thierry Daloze; Gilles Plourde; Steven B Backman; Mirko Diksic; Pierre-Olivier Fiset
PET quantification of muscarinic cholinergic receptors with [N-11C-methyl]-benztropine and application to studies of propofol-induced unconsciousness in healthy human volunteers.
Synapse (New York, N.Y.) 2004;51(2):91-101.
2003: Federico E Turkheimer; Rainer Hinz; Roger Gunn; John A D Aston; Steve R Gunn; Vincent J Cunningham
Rank-shaping regularization of exponential spectral analysis for application to functional parametric mapping.
Physics in medicine and biology 2003;48(23):3819-41.
2003: Rodrigo A Bressan; Kjell Erlandsson; Rachel S Mulligan; Roger Gunn; Vincent J Cunningham; Jonathan Owens; Peter J Ell; Lyn S Pilowsky
Evaluation of NMDA receptors in vivo in schizophrenic patients with [123I]CNS 1261 and SPET: preliminary findings.
Annals of the New York Academy of Sciences 2003;1003():364-7.
2003: Alexander Gerhard; Richard B Banati; G B Goerres; Annachiara Cagnin; R Myers; Roger Gunn; Federico E Turkheimer; C D Good; Christopher J Mathias; Niall Quinn; Johannes Schwarz; David J Brooks
[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.
Neurology 2003;61(5):686-9.
2003: Paula Wells; Eric O Aboagye; Roger Gunn; Safiye Osman; Alan V Boddy; Gordon A Taylor; Imran Rafi; Andrew N Hughes; A Hilary Calvert; Patricia M Price; David R Newell
2-[11C]thymidine positron emission tomography as an indicator of thymidylate synthase inhibition in patients treated with AG337.
Journal of the National Cancer Institute 2003;95(9):675-82.
2003: Kjell Erlandsson; Rodrigo A Bressan; Rachel S Mulligan; Roger Gunn; Vincent J Cunningham; Jonathan Owens; David Wyper; Peter J Ell; Lyn S Pilowsky
Kinetic modelling of [123I]CNS 1261--a potential SPET tracer for the NMDA receptor.
Nuclear medicine and biology 2003;30(4):441-54.
2002: Roger Gunn; Steve R Gunn; Federico E Turkheimer; John A D Aston; Vincent J Cunningham
Positron emission tomography compartmental models: a basis pursuit strategy for kinetic modeling.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(12):1425-39.
2002: Paula Wells; Roger Gunn; Malcolm Alison; Colin Steel; Mathew Golding; Alex S Ranicar; Frank Brady; Safiye Osman; Terry Jones; Pat Price
Assessment of proliferation in vivo using 2-[(11)C]thymidine positron emission tomography in advanced intra-abdominal malignancies.
Cancer research 2002;62(20):5698-702.
2002: Eugenii A Rabiner; Roger Gunn; Martin R Wilkins; Ewen Sedman; Paul M Grasby
Evaluation of EMD 128 130 occupancy of the 5-HT1A and the D2 receptor: a human PET study with [11C]WAY-100635 and [11C]raclopride.
Journal of psychopharmacology (Oxford, England) 2002;16(3):195-9.
2002: John A D Aston; Vincent J Cunningham; Marie-Claude Asselin; Alexander Hammers; Alan C Evans; Roger Gunn
Positron emission tomography partial volume correction: estimation and algorithms.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(8):1019-34.
2002: Eugenii A Rabiner; Martin R Wilkins; Federico E Turkheimer; Roger Gunn; Joanna Udo de Haes; Michiel de Vries; Paul M Grasby
5-Hydroxytryptamine1A receptor occupancy by novel full antagonist 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: a[11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY-100635) positron emission tomography study in humans.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1144-50.
2002: Bengt Andrée; Christer Halldin; Victor W Pike; Roger Gunn; Hans Olsson; Lars Farde
The PET radioligand [carbonyl-(11)C]desmethyl-WAY-100635 binds to 5-HT(1A) receptors and provides a higher radioactive signal than [carbonyl-(11)C]WAY-100635 in the human brain.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(3):292-303.
2002: Eugenii A Rabiner; Cristina Messa; Peter A Sargent; Karen Husted-Kjaer; Andrew Montgomery; Andrew D Lawrence; Christopher J Bench; Roger Gunn; Philip J Cowen; Paul M Grasby
A database of [(11)C]WAY-100635 binding to 5-HT(1A) receptors in normal male volunteers: normative data and relationship to methodological, demographic, physiological, and behavioral variables.
NeuroImage 2002;15(3):620-32.
2001: Eugenii A Rabiner; Zubin Bhagwagar; Roger Gunn; Peter A Sargent; Christopher J Bench; Philip J Cowen; Paul M Grasby
Pindolol augmentation of selective serotonin reuptake inhibitors: PET evidence that the dose used in clinical trials is too low.
The American journal of psychiatry 2001;158(12):2080-2.
2001: Richard B Banati; Annachiara Cagnin; David J Brooks; Roger Gunn; R Myers; T Jones; R Birch; P Anand
Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury.
Neuroreport 2001;12(16):3439-42.
2001: Andrew J Montgomery; Christopher J Bench; A H Young; Alexander Hammers; Roger Gunn; Zubin Bhagwagar; Paul M Grasby
PET measurement of the influence of corticosteroids on serotonin-1A receptor number.
Biological psychiatry 2001;50(9):668-76.
2001: Alain Dagher; C Bleicher; John A D Aston; Roger Gunn; Paul B S Clarke; Paul Cumming
Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokers.
Synapse (New York, N.Y.) 2001;42(1):48-53.
2001: Annachiara Cagnin; R Myers; Roger Gunn; Andrew D Lawrence; T Stevens; Georg W Kreutzberg; T Jones; Richard B Banati
In vivo visualization of activated glia by [11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion.
Brain : a journal of neurology 2001;124(Pt 10):2014-27.
2001: Annachiara Cagnin; David J Brooks; A M Kennedy; Roger Gunn; R Myers; Federico E Turkheimer; T Jones; Richard B Banati
In-vivo measurement of activated microglia in dementia.
Lancet 2001;358(9280):461-7.
2001: Julie C Price; Brian J Lopresti; Carolyn Meltzer; Gwenn S Smith; N Scott Mason; Yiyun Huang; Daniel P Holt; Roger Gunn; Chester A Mathis
Analyses of [(18)F]altanserin bolus injection PET data. II: consideration of radiolabeled metabolites in humans.
Synapse (New York, N.Y.) 2001;41(1):11-21.
2001: Roger Gunn; Steve R Gunn; Vincent J Cunningham
Positron emission tomography compartmental models.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(6):635-52.
2000: Richard B Banati; Jia Newcombe; Roger Gunn; Annachiara Cagnin; Federico E Turkheimer; F Heppner; G Price; Florian Wegner; G Giovannoni; D H Miller; G D Perkin; Terence Smith; Adrian Hewson-Hughes; G Bydder; Georg W Kreutzberg; T Jones; M Louise Cuzner; R Myers
The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity.
Brain : a journal of neurology 2000;123 ( Pt 11)():2321-37.
2000: Sabina Pappata; M Levasseur; Roger Gunn; R Myers; Christian Crouzel; André Syrota; T Jones; G W Kreutzberg; Richard B Banati
Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.
Neurology 2000;55(7):1052-4.
2000: John A D Aston; Roger Gunn; Keith J Worsley; Y Ma; Alan C Evans; Alain Dagher
A statistical method for the analysis of positron emission tomography neuroreceptor ligand data.
NeuroImage 2000;12(3):245-56.
2000: Eugenii A Rabiner; Roger Gunn; M Elena Castro; Peter A Sargent; Philip J Cowen; Matthias Koepp; Jeffrey H Meyer; Christopher J Bench; P J Harrison; Angel Pazos; Trevor Sharp; Paul M Grasby
beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;23(3):285-93.
2000: Eugenii A Rabiner; Roger Gunn; Martin R Wilkins; Peter A Sargent; E Mocaer; E Sedman; Philip J Cowen; Paul M Grasby
Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-(11)C]WAY-100635.
Nuclear medicine and biology 2000;27(5):509-13.
2000: Roger Gunn; A A Lammertsma; Paul M Grasby
Quantitative analysis of [carbonyl-(11)C]WAY-100635 PET studies.
Nuclear medicine and biology 2000;27(5):477-82.
2000: Susan P Hume; Ella Hirani; Jolanta Opacka-Juffry; Safiye Osman; R Myers; Roger Gunn; Julie A McCarron; R D Clark; Jan K Melichar; David J Nutt; Victor W Pike
Evaluation of [O-methyl-11C]RS-15385-197 as a positron emission tomography radioligand for central alpha2-adrenoceptors.
European journal of nuclear medicine 2000;27(5):475-84.
2000: Federico E Turkheimer; Richard B Banati; D Visvikis; John A D Aston; Roger Gunn; Vincent J Cunningham
Modeling dynamic PET-SPECT studies in the wavelet domain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(5):879-93.
2000: Roger Gunn; J T Yap; Paula Wells; S Osman; P Price; T Jones; V J Cunningham
A general method to correct PET data for tissue metabolites using a dual-scan approach.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(4):706-11.
2000: Roger Gunn; Alex S Ranicar; J T Yap; Paula Wells; S Osman; T Jones; V J Cunningham
On-line measurement of exhaled [11C]CO2 during PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(4):605-11.
2000: Peter A Sargent; K H Kjaer; Christopher J Bench; Eugenii A Rabiner; C Messa; J Meyer; Roger Gunn; Paul M Grasby; Philip J Cowen
Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.
Archives of general psychiatry 2000;57(2):174-80.
1999: Richard B Banati; G W Goerres; R Myers; Roger Gunn; Federico E Turkheimer; G W Kreutzberg; David J Brooks; T Jones; J S Duncan
[11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis.
Neurology 1999;53(9):2199-203.
1999: Thomasin C Andrews; RA Weeks; N Turjanski; Roger Gunn; Laura H Watkins; Barbara J Sahakian; John R Hodges; Anne E Rosser; Nicholas W Wood; David J Brooks
Huntington's disease progression. PET and clinical observations.
Brain : a journal of neurology 1999;122 ( Pt 12)():2353-63.
1999: Paola Piccini; David J Brooks; Anders Björklund; Roger Gunn; Paul M Grasby; Ornella E Rimoldi; Patrik Brundin; Peter Hagell; Stig Rehncrona; Håkan Widner; Olle Lindvall
Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient.
Nature neuroscience 1999;2(12):1137-40.
1999: J H Meyer; Roger Gunn; R Myers; Paul M Grasby
Assessment of spatial normalization of PET ligand images using ligand-specific templates.
NeuroImage 1999;9(5):545-53.
1998: Roger Gunn; Peter A Sargent; Christopher J Bench; Eugenii A Rabiner; Safiye Osman; Victor W Pike; Susan P Hume; Paul M Grasby; AA Lammertsma
Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C]WAY-100635 for PET.
NeuroImage 1998;8(4):426-40.
1998: Matthias Koepp; Roger Gunn; Andrew D Lawrence; Vincent J Cunningham; Alain Dagher; Terry Jones; David J Brooks; Christopher J Bench; Paul M Grasby
Evidence for striatal dopamine release during a video game.
Nature 1998;393(6682):266-8.
1998: Safiye Osman; Camilla Lundkvist; Victor W Pike; Christer Halldin; Julie A McCarron; Carl-Gunnar Swahn; Lars Farde; N Ginovart; Sajinder K Luthra; Roger Gunn; Christopher J Bench; Peter A Sargent; Paul M Grasby
Characterisation of the appearance of radioactive metabolites in monkey and human plasma from the 5-HT1A receptor radioligand, [carbonyl-11C]WAY-100635--explanation of high signal contrast in PET and an aid to biomathematical modelling.
Nuclear medicine and biology 1998;25(3):215-23.
1998: Michael J Chappell; Roger Gunn
A procedure for generating locally identifiable reparameterisations of unidentifiable non-linear systems by the similarity transformation approach.
Mathematical biosciences 1998;148(1):21-41.
1998: Susan P Hume; Roger Gunn; Terry Jones
Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals.
European journal of nuclear medicine 1998;25(2):173-6.
1997: Roger Gunn; AA Lammertsma; Susan P Hume; Vincent J Cunningham
Parametric imaging of ligand-receptor binding in PET using a simplified reference region model.
NeuroImage 1997;6(4):279-87.
1997: Andrea L Malizia; J M Melichar; D J Brown; Roger Gunn; Alan Reynolds; Terry Jones; David J Nutt
Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo.
Journal of psychopharmacology (Oxford, England) 1997;11(3):279-81.
1996: H L Boyd; Roger Gunn; N V Marinho; S P Karwatowski; Dale Bailey; D C Costa; Paolo G Camici
Non-invasive measurement of left ventricular volumes and function by gated positron emission tomography.
European journal of nuclear medicine 1996;23(12):1594-602.
1996: Vincent J Cunningham; Stuart D Rosen; H Boyd; Safiye Osman; R J Davenport; Roger Gunn; Victor W Pike; Paolo G Camici
Uptake of [N-methyl-11C]propionyl-L-carnitine (PLC) in human myocardium.
The Journal of pharmacology and experimental therapeutics 1996;277(1):511-7.
1996: Andrea L Malizia; Roger Gunn; S J Wilson; S H Waters; P M Bloomfield; Vincent J Cunningham; David J Nutt
Benzodiazepine site pharmacokinetic/pharmacodynamic quantification in man: direct measurement of drug occupancy and effects on the human brain in vivo.
Neuropharmacology 1996;35(9-10):1483-91.