Thomas Wisniewski

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Sadowski Martin J; Pankiewicz Joanna; Prelli Frances; Scholtzova Henrieta; Spinner Daryl S; Kascsak Regina B; Kascsak Richard J; Wisniewski Thomas
Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo.
Mosconi Lisa; Mistur Rachel; Switalski Remigiusz; Tsui Wai Hon; Glodzik Lidia; Li Yi; Pirraglia Elizabeth; De Santi Susan; Reisberg Barry; Wisniewski Thomas; de Leon Mony J
FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease.
Wisniewski Thomas
AD vaccines: conclusions and future directions.

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All Publications

2009: Sadowski Martin J; Pankiewicz Joanna; Prelli Frances; Scholtzova Henrieta; Spinner Daryl S; Kascsak Regina B; Kascsak Richard J; Wisniewski Thomas
Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo.
Neurobiology of disease 2009;34(2):267-78.
2009: Mosconi Lisa; Mistur Rachel; Switalski Remigiusz; Tsui Wai Hon; Glodzik Lidia; Li Yi; Pirraglia Elizabeth; De Santi Susan; Reisberg Barry; Wisniewski Thomas; de Leon Mony J
FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease.
European journal of nuclear medicine and molecular imaging 2009;36(5):811-22.
2009: Wisniewski Thomas
AD vaccines: conclusions and future directions.
CNS & neurological disorders drug targets 2009;8(2):160-6.
2009: Zhan Jiong; Brys Miroslaw; Glodzik Lidia; Tsui Wai; Javier Elizabeth; Wegiel Jerzy; Kuchna Izabela; Pirraglia Elizabeth; Li Yi; Mosconi Lisa; Saint Louis Leslie A; Switalski Remigiusz; De Santi Susan; Kim Byeong C; Wisniewski Thomas; Reisberg Barry; Bobinski Matthew; de Leon Mony J
An entorhinal cortex sulcal pattern is associated with Alzheimer's disease.
Human brain mapping 2009;30(3):874-82.
2009: Scholtzova Henrieta; Kascsak Richard J; Bates Kristyn A; Boutajangout Allal; Kerr Daniel J; Meeker Harry C; Mehta Pankaj D; Spinner Daryl S; Wisniewski Thomas
Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's disease-related pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(6):1846-54.
2009: Trouche Stéphanie G; Asuni Ayodeji; Rouland Sylvie; Wisniewski Thomas; Frangione Blas; Verdier Jean-Michel; Sigurdsson Einar M; Mestre-Francés Nadine
Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives.
Vaccine 2009;27(7):957-64.
2008: Spinner Daryl S; Cho In Soo; Park Seung Yong; Kim Jae Il; Meeker Harry C; Ye Xuemin; Lafauci Giuseppe; Kerr Daniel J; Flory Michael J; Kim Bo Sook; Kascsak Regina B; Wisniewski Thomas; Levis William R; Schuller-Levis Georgia B; Carp Richard I; Park Eunkyue; Kascsak Richard J
Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice.
Journal of virology 2008;82(21):10701-8.
2008: Wegiel Jerzy; Dowjat Karol; Kaczmarski Wojciech; Kuchna Izabela; Nowicki Krzysztof; Frackowiak Janusz; Mazur Kolecka Bozena; Wegiel Jarek; Silverman Wayne P; Reisberg Barry; Deleon Mony; Wisniewski Thomas; Gong Cheng-Xin; Liu Fei; Adayev Tatyana; Chen-Hwang Mo-Chou; Hwang Yu-Wen
The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome.
Acta neuropathologica 2008;116(4):391-407.
2008: Cercy Steven P; Sadowski Martin J; Wisniewski Thomas
Prominent neuroleptic sensitivity in a case of early-onset Alzheimer disease due to presenilin-1 G206A mutation.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 2008;21(3):190-5.
2008: Wisniewski Thomas; Konietzko Uwe
Amyloid-beta immunisation for Alzheimer's disease.
Lancet neurology 2008;7(9):805-11.
2008: Scholtzova Henrieta; Wadghiri Youssef Z; Douadi Moustafa; Sigurdsson Einar M; Li Yong-Sheng; Quartermain David; Banerjee Pradeep; Wisniewski Thomas
Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging.
Journal of neuroscience research 2008;86(12):2784-91.
2008: Gambetti Pierluigi; Dong Zhiqian; Yuan Jue; Xiao Xiangzhu; Zheng Mengjie; Alshekhlee Amer; Castellani Rudy; Cohen Mark; Barria Marcelo A; Gonzalez-Romero D; Belay Ermias D; Schonberger Lawrence B; Marder Karen; Harris Carrie; Burke James R; Montine Thomas; Wisniewski Thomas; Dickson Dennis W; Soto Claudio; Hulette Christine M; Mastrianni James A; Kong Qingzhong; Zou Wen-Quan
A novel human disease with abnormal prion protein sensitive to protease.
Annals of neurology 2008;63(6):697-708.
2008: Sigurdsson Einar M; Wadghiri Youssef Z; Mosconi Lisa; Blind Jeffrey A; Knudsen Elin; Asuni Ayodeji; Scholtzova Henrieta; Tsui Wai H; Li Yongsheng; Sadowski Martin; Turnbull Daniel H; de Leon Mony J; Wisniewski Thomas
A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice.
Neurobiology of aging 2008;29(6):836-47.
2008: Goñi F; Prelli F; Schreiber F; Scholtzova H; Chung E; Kascsak R; Brown D R; Sigurdsson E M; Chabalgoity J A; Wisniewski T
High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice.
Neuroscience 2008;153(3):679-86.
2008: Klyubin Igor; Betts Vicki; Welzel Alfred T; Blennow Kaj; Zetterberg Henrik; Wallin Anders; Lemere Cynthia A; Cullen William K; Peng Ying; Wisniewski Thomas; Selkoe Dennis J; Anwyl Roger; Walsh Dominic M; Rowan Michael J
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(16):4231-7.
2008: Firuzi Omidreza; Zhuo Jiamin; Chinnici Cinzia M; Wisniewski Thomas; Praticò Domenico
5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(4):1169-78.
2008: Wisniewski Thomas; Sadowski Martin
Preventing beta-amyloid fibrillization and deposition: beta-sheet breakers and pathological chaperone inhibitors.
BMC neuroscience 2008;9 Suppl 2():S5.
2007: Webb Sarah; Lekishvili Tamuna; Loeschner Corinna; Sellarajah Shane; Prelli Frances; Wisniewski Thomas; Gilbert Ian H; Brown David R
Mechanistic insights into the cure of prion disease by novel antiprion compounds.
Journal of virology 2007;81(19):10729-41.
2007: Li Qian; Min Jaeki; Ahn Young-Hoon; Namm Joshua; Kim Eun Min; Lui Rowena; Kim Hye Yun; Ji Yong; Wu Hueizhi; Wisniewski Thomas; Chang Young-Tae
Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques.
Chembiochem : a European journal of chemical biology 2007;8(14):1679-87.
2007: Wisniewski Thomas; Sigurdsson Einar M
Therapeutic approaches for prion and Alzheimer's diseases.
The FEBS journal 2007;274(15):3784-98.
2007: Litterst Claudia; Georgakopoulos Anastasios; Shioi Junichi; Ghersi Enrico; Wisniewski Thomas; Wang Rong; Ludwig Andreas; Robakis Nikolaos K
Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.
The Journal of biological chemistry 2007;282(22):16155-63.
2007: Spinner Daryl S; Kascsak Regina B; Lafauci Giuseppe; Meeker Harry C; Ye Xuemin; Flory Michael J; Kim Jae Il; Schuller-Levis Georgia B; Levis William R; Wisniewski Thomas; Carp Richard I; Kascsak Richard J
CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils.
Journal of leukocyte biology 2007;81(6):1374-85.
2007: Wisniewski T; Chabalgoity J A; Goni F
Is vaccination against transmissible spongiform encephalopathy feasible?
Revue scientifique et technique (International Office of Epizootics) 2007;26(1):243-51.
2007: Wegiel Jerzy; Kuchna Izabela; Nowicki Krzysztof; Frackowiak Janusz; Mazur-Kolecka Bozena; Imaki Humi; Wegiel Jarek; Mehta Pankaj D; Silverman Wayne P; Reisberg Barry; Deleon Mony; Wisniewski Thomas; Pirttilla Tuula; Frey Harry; Lehtimäki Terho; Kivimäki Tarmo; Visser Frank E; Kamphorst Wouter; Potempska Anna; Bolton David; Currie Julia R; Miller David L
Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration.
Acta neuropathologica 2007;113(4):389-402.
2007: Chang Binggong; Cheng Xin; Yin Shaoman; Pan Tao; Zhang Hongtao; Wong Poki; Kang Shin-Chung; Xiao Fan; Yan Huimin; Li Chaoyang; Wolfe Lisa L; Miller Michael W; Wisniewski Thomas; Greene Mark I; Sy Man-Sun
Test for detection of disease-associated prion aggregate in the blood of infected but asymptomatic animals.
Clinical and vaccine immunology : CVI 2007;14(1):36-43.
2007: Sadowski Marcin; Wisniewski Thomas
Disease modifying approaches for Alzheimer's pathology.
Current pharmaceutical design 2007;13(19):1943-54.
2006: Sadowski Martin J; Pankiewicz Joanna; Scholtzova Henrieta; Mehta Pankaj D; Prelli Frances; Quartermain David; Wisniewski Thomas
Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18787-92.
2006: Asuni Ayodeji A; Boutajangout Allal; Scholtzova Henrieta; Knudsen Elin; Li Yong Sheng; Quartermain David; Frangione Blas; Wisniewski Thomas; Sigurdsson Einar M
Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages.
The European journal of neuroscience 2006;24(9):2530-42.
2006: Leal María C; Dorfman Verónica B; Gamba Agata Fernández; Frangione Blas; Wisniewski Thomas; Castaño Eduardo M; Sigurdsson Einar M; Morelli Laura
Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology.
Journal of neuropathology and experimental neurology 2006;65(10):976-87.
2006: Pankiewicz Joanna; Prelli Frances; Sy Man-Sun; Kascsak Richard J; Kascsak Regina B; Spinner Daryl S; Carp Richard I; Meeker Harry C; Sadowski Marcin; Wisniewski Thomas
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.
The European journal of neuroscience 2006;23(10):2635-47.
2005: Sigurdsson Einar M; Wisniewski Thomas
Promising developments in prion immunotherapy.
Expert review of vaccines 2005;4(5):607-10.
2005: Pan Tao; Chang Binggong; Wong Poki; Li Chaoyang; Li Ruliang; Kang Shin-Chung; Robinson John D; Thompsett Andrew R; Tein Po; Yin Shaoman; Barnard Geoff; McConnell Ian; Brown David R; Wisniewski Thomas; Sy Man-Sun
An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates.
Journal of virology 2005;79(19):12355-64.
2005: Sassoon J; Sadowski M; Wisniewski T; Brown D R
Therapeutics and prion disease: can immunisation or drugs be effective?
Mini reviews in medicinal chemistry 2005;5(4):361-6.
2005: Wisniewski Thomas; Frangione Blas
Immunological and anti-chaperone therapeutic approaches for Alzheimer disease.
Brain pathology (Zurich, Switzerland) 2005;15(1):72-7.
2005: Pan Tao; Wong Poki; Chang Binggong; Li Chaoyang; Li Ruliang; Kang Shin-Chung; Wisniewski Thomas; Sy Man-Sun
Biochemical fingerprints of prion infection: accumulations of aberrant full-length and N-terminally truncated PrP species are common features in mouse prion disease.
Journal of virology 2005;79(2):934-43.
2005: Wadghiri Youssef Zaim; Sigurdsson Einar M; Wisniewski Thomas; Turnbull Daniel H
Magnetic resonance imaging of amyloid plaques in transgenic mice.
Methods in molecular biology (Clifton, N.J.) 2005;299():365-79.
2005: Goñi F; Knudsen E; Schreiber F; Scholtzova H; Pankiewicz J; Carp R; Meeker H C; Rubenstein R; Brown D R; Sy M-S; Chabalgoity J A; Sigurdsson E M; Wisniewski T
Mucosal vaccination delays or prevents prion infection via an oral route.
Neuroscience 2005;133(2):413-21.
2004: Ghiso Jorge; Wisniewski Thomas
An animal model of vascular amyloidosis.
Nature neuroscience 2004;7(9):902-4.
2004: Sadowski Marcin; Pankiewicz Joanna; Scholtzova Henrieta; Ripellino James A; Li Yongsheng; Schmidt Stephen D; Mathews Paul M; Fryer John D; Holtzman David M; Sigurdsson Einar M; Wisniewski Thomas
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.
The American journal of pathology 2004;165(3):937-48.
2004: Pan Tao; Li Ruliang; Kang Shin-Cheng; Wong Boon-Seng; Wisniewski Thomas; Sy Man-Sun
Epitope scanning reveals gain and loss of strain specific antibody binding epitopes associated with the conversion of normal cellular prion to scrapie prion.
Journal of neurochemistry 2004;90(5):1205-17.
2004: Sadowski Marcin; Pankiewicz Joanna; Scholtzova Henrieta; Tsai Julia; Li Yongsheng; Carp Richard I; Meeker Harry C; Gambetti Pierluigi; Debnath Manik; Mathis Chester A; Shao Li; Gan Wen-Biao; Klunk William E; Wisniewski Thomas
Targeting prion amyloid deposits in vivo.
Journal of neuropathology and experimental neurology 2004;63(7):775-84.
2004: Sigurdsson Einar M; Knudsen Elin; Asuni Ayodeji; Fitzer-Attas Cheryl; Sage Daniel; Quartermain David; Goni Fernando; Frangione Blas; Wisniewski Thomas
An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(28):6277-82.
2004: Sadowski Marcin; Wisniewski Thomas
Vaccines for conformational disorders.
Expert review of vaccines 2004;3(3):279-90.
2004: Sadowski Marcin; Pankiewicz Joanna; Scholtzova Henrieta; Li Yong-sheng; Quartermain David; Duff Karen; Wisniewski Thomas
Links between the pathology of Alzheimer's disease and vascular dementia.
Neurochemical research 2004;29(6):1257-66.
2004: Wegiel Jerzy; Kuchna Izabela; Nowicki Krzysztof; Frackowiak Janusz; Dowjat Karol; Silverman Wayne P; Reisberg Barry; DeLeon Mony; Wisniewski Thomas; Adayev Tatyana; Chen-Hwang Mo-Chou; Hwang Yu-Wen
Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain.
Brain research 2004;1010(1-2):69-80.
2004: Sadowski Marcin; Pankiewicz Joanna; Scholtzova Henrieta; Ji Yong; Quartermain David; Jensen Catrin H; Duff Karen; Nixon Ralph A; Gruen Rand J; Wisniewski Thomas
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.
Journal of neuropathology and experimental neurology 2004;63(5):418-28.
2004: Kang Shin-Chung; Brown David R; Whiteman Matthew; Li Ruliang; Pan Tao; Perry George; Wisniewski Thomas; Sy Man-Sun; Wong Boon-Seng
Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice.
The Journal of pathology 2004;203(1):603-8.
2004: Helpern Joseph A; Lee Sang-Pil; Falangola Maria F; Dyakin Victor V; Bogart Adam; Ardekani Babak; Duff Karen; Branch Craig; Wisniewski Thomas; de Leon Mony J; Wolf Oliver; O'Shea Jacqueline; Nixon Ralph A
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(4):794-8.
2004: Dowjat Wieslaw K; Kuchna Izabela; Wisniewski Thomas; Wegiel Jerzy
A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations.
Journal of Alzheimer's disease : JAD 2004;6(1):31-43.
2003: Sigurdsson Einar M; Brown David R; Alim Muhammad A; Scholtzova Henrieta; Carp Richard; Meeker Harry C; Prelli Frances; Frangione Blas; Wisniewski Thomas
Copper chelation delays the onset of prion disease.
The Journal of biological chemistry 2003;278(47):46199-202.
2003: Wadghiri Youssef Zaim; Sigurdsson Einar M; Sadowski Marcin; Elliott James I; Li Yongsheng; Scholtzova Henrieta; Tang Cheuk Ying; Aguinaldo Gilbert; Pappolla Miguel; Duff Karen; Wisniewski Thomas; Turnbull Daniel H
Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;50(2):293-302.
2003: Sadowski Marcin; Tang Cheuk Ying; Aguinaldo Juan Gilberto; Carp Richard; Meeker Harry C; Wisniewski Thomas
In vivo micro magnetic resonance imaging signal changes in scrapie infected mice.
Neuroscience letters 2003;345(1):1-4.
2003: Wong B-S; Li R; Sassoon J; Kang S-C; Liu T; Pan T; Greenspan N S; Wisniewski T; Brown D R; Sy M-S
Mapping the antigenicity of copper-treated cellular prion protein with the scrapie isoform.
Cellular and molecular life sciences : CMLS 2003;60(6):1224-34.
2003: Sigurdsson Einar M; Sy Man-Sun; Li Ruliang; Scholtzova Henrieta; Kascsak Richard J; Kascsak Regina; Carp Richard; Meeker Harry C; Frangione Blas; Wisniewski Thomas
Anti-prion antibodies for prophylaxis following prion exposure in mice.
Neuroscience letters 2003;336(3):185-7.
2003: Ji Y; Gong Y; Gan W; Beach T; Holtzman D M; Wisniewski T
Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients.
Neuroscience 2003;122(2):305-15.
2002: Poduslo Joseph F; Wengenack Thomas M; Curran Geoffry L; Wisniewski Thomas; Sigurdsson Einar M; Macura Slobodon I; Borowski Bret J; Jack Clifford R
Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.
Neurobiology of disease 2002;11(2):315-29.
2002: Sigurdsson Einar M; Wisniewski Thomas; Frangione Blas
A safer vaccine for Alzheimer's disease?
Neurobiology of aging 2002;23(6):1001-8.
2002: de Leon M J; Segal S; Tarshish C Y; DeSanti S; Zinkowski R; Mehta P D; Convit A; Caraos C; Rusinek H; Tsui W; Saint Louis L A; DeBernardis J; Kerkman D; Qadri F; Gary A; Lesbre P; Wisniewski T; Poirier J; Davies P
Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment.
Neuroscience letters 2002;333(3):183-6.
2002: Sigurdsson Einar M; Wisniewski Thomas; Frangione Blas
Infectivity of amyloid diseases.
Trends in molecular medicine 2002;8(9):411-3.
2002: Wisniewski Thomas; Sigurdsson Einar M
Immunization treatment approaches in Alzheimer's and prion diseases.
Current neurology and neuroscience reports 2002;2(5):400-4.
2002: Wisniewski T; Brown D R; Sigurdsson E M
Therapeutics in Alzheimer's and prion diseases.
Biochemical Society transactions 2002;30(4):574-8.
2002: Sigurdsson Einar M; Brown David R; Daniels Maki; Kascsak Richard J; Kascsak Regina; Carp Richard; Meeker Harry C; Frangione Blas; Wisniewski Thomas
Immunization delays the onset of prion disease in mice.
The American journal of pathology 2002;161(1):13-7.
2002: Mackic Jasmina B; Bading James; Ghiso Jorge; Walker Larry; Wisniewski Thomas; Frangione Blas; Zlokovic Berislav V
Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.
Vascular pharmacology 2002;38(6):303-13.
2002: Mori Chica; Spooner Edward T; Wisniewsk Krystyna E; Wisniewski Thomas M; Yamaguch Haruyasu; Saido Takaom C; Tolan Dean R; Selkoe Dennis J; Lemere Cynthia A
Intraneuronal Abeta42 accumulation in Down syndrome brain.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2002;9(2):88-102.
2002: Wen Paul H; Shao Xiang; Shao Zhiping; Hof Patrick R; Wisniewski Thomas; Kelley Kevin; Friedrich Victor L; Ho Lap; Pasinetti Giulio M; Shioi Junichi; Robakis Nikolaos K; Elder Gregory A
Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice.
Neurobiology of disease 2002;10(1):8-19.
2002: Marambaud Philippe; Shioi Junichi; Serban Geo; Georgakopoulos Anastasios; Sarner Shula; Nagy Vanja; Baki Lia; Wen Paul; Efthimiopoulos Spiros; Shao Zhiping; Wisniewski Thomas; Robakis Nikolaos K
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.
The EMBO journal 2002;21(8):1948-56.
2002: Wegiel J; Kuchna I; Wisniewski T; de Leon M J; Reisberg B; Pirttila T; Kivimaki T; Lehtimaki T
Vascular fibrosis and calcification in the hippocampus in aging, Alzheimer disease, and Down syndrome.
Acta neuropathologica 2002;103(4):333-43.
2002: Wang Z H; Ji Y; Shan W; Zeng B; Raksadawan N; Pastores G M; Wisniewski T; Kolodny E H
Therapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease.
Neuroscience 2002;113(3):629-40.
2001: Poeggeler B; Miravalle L; Zagorski M G; Wisniewski T; Chyan Y J; Zhang Y; Shao H; Bryant-Thomas T; Vidal R; Frangione B; Ghiso J; Pappolla M A
Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.
Biochemistry 2001;40(49):14995-5001.
2001: Aucouturier P; Geissmann F; Damotte D; Saborio G P; Meeker H C; Kascsak R; Kascsak R; Carp R I; Wisniewski T
Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie.
The Journal of clinical investigation 2001;108(5):703-8.
2001: Sigurdsson E M; Scholtzova H; Mehta P D; Frangione B; Wisniewski T
Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.
The American journal of pathology 2001;159(2):439-47.
2001: Wegiel J; Bobinski M; Tarnawski M; Dziewiatkowski J; Popovitch E; Miller D C; Wisniewski T; Golomb J; de Leon M J; Reisberg B
Fibrillar amyloid-beta affects neurofibrillary changes but only in neurons already involved in neurofibrillary degeneration.
Acta neuropathologica 2001;101(6):585-90.
2001: Kulczycki J; Bertrand E; Lojkowska W; Dowjat W; Wisniewski T; Lyczywek-Zwierz M
[Familial Alzheimer's disease connected with mutation in presenilin gene 1 (P117L)]
Neurologia i neurochirurgia polska 2001;35(2):213-24.
2001: Dowjat W K; Wisniewski H; Wisniewski T
Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments.
Neuroscience 2001;103(1):1-8.
2000: Golabek A A; Kida E; Walus M; Perez C; Wisniewski T; Soto C
Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E.
Biophysical journal 2000;79(2):1008-15.
2000: Aucouturier P; Carp R I; Carnaud C; Wisniewski T
Prion diseases and the immune system.
Clinical immunology (Orlando, Fla.) 2000;96(2):79-85.
2000: Kayden H J; Wisniewski T
On the biological activity of vitamin E.
The American journal of clinical nutrition 2000;72(1):201-3.
2000: Stoltzner S E; Grenfell T J; Mori C; Wisniewski K E; Wisniewski T M; Selkoe D J; Lemere C A
Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease.
The American journal of pathology 2000;156(2):489-99.
2000: Sigurdsson E M; Permanne B; Soto C; Wisniewski T; Frangione B
In vivo reversal of amyloid-beta lesions in rat brain.
Journal of neuropathology and experimental neurology 2000;59(1):11-7.
2000: Soto C; Kascsak R J; Saborío G P; Aucouturier P; Wisniewski T; Prelli F; Kascsak R; Mendez E; Harris D A; Ironside J; Tagliavini F; Carp R I; Frangione B
Reversion of prion protein conformational changes by synthetic beta-sheet breaker peptides.
Lancet 2000;355(9199):192-7.
1999: Aucouturier P; Kascsak R J; Frangione B; Wisniewski T
Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt-Jakob disease.
Neuroscience letters 1999;274(1):33-6.
1999: Dowjat W K; Wisniewski T; Efthimiopoulos S; Wisniewski H M
Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations.
Neuroscience letters 1999;267(2):141-4.
1999: Copp R P; Wisniewski T; Hentati F; Larnaout A; Ben Hamida M; Kayden H J
Localization of alpha-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders.
Brain research 1999;822(1-2):80-7.
1999: Aucouturier P; Frangione B; Wisniewski T
Prion diseases and the immune system.
Annales de médecine interne 1999;150(2):75-8.
1998: Efthimiopoulos S; Floor E; Georgakopoulos A; Shioi J; Cui W; Yasothornsrikul S; Hook V Y; Wisniewski T; Buee L; Robakis N K
Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles.
Journal of neurochemistry 1998;71(6):2365-72.
1998: Pomara N; Shao B; Wisniewski T; Mehta P D
Decreases in plasma A beta 1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 allele.
Neurochemical research 1998;23(12):1563-6.
1998: Wisniewski T; Aucouturier P; Soto C; Frangione B
The prionoses and other conformational disorders.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1998;5(3):212-24.
1998: Wegiel J; Wisniewski H M; Kuchna I; Tarnawski M; Badmajew E; Popovitch E; Kulczycki J; Dowjat W K; Wisniewski T
Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L).
Journal of neuropathology and experimental neurology 1998;57(9):831-8.
1998: Askanas V; Engel W K; Yang C C; Alvarez R B; Lee V M; Wisniewski T
Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy.
The American journal of pathology 1998;152(4):889-95.
1998: Wisniewski T; Goldman J E
Alpha B-crystallin is associated with intermediate filaments in astrocytoma cells.
Neurochemical research 1998;23(3):385-92.
1998: Wisniewski T; Dowjat W K; Buxbaum J D; Khorkova O; Efthimiopoulos S; Kulczycki J; Lojkowska W; Wegiel J; Wisniewski H M; Frangione B
A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.
Neuroreport 1998;9(2):217-21.
1998: Wisniewski K E; Zhong N; Kaczmarski W; Kaczmarski A; Kida E; Brown W T; Schwarz K O; Lazzarini A M; Rubin A J; Stenroos E S; Johnson W G; Wisniewski T M
Compound heterozygous genotype is associated with protracted juvenile neuronal ceroid lipofuscinosis.
Annals of neurology 1998;43(1):106-10.
1997: Permanne B; Perez C; Soto C; Frangione B; Wisniewski T
Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.
Biochemical and biophysical research communications 1997;240(3):715-20.
1997: Wisniewski T; Dowjat W K; Permanne B; Palha J; Kumar A; Gallo G; Frangione B
Presenilin-1 is associated with Alzheimer's disease amyloid.
The American journal of pathology 1997;151(2):601-10.
1997: Ghiso J; Calero M; Matsubara E; Governale S; Chuba J; Beavis R; Wisniewski T; Frangione B
Alzheimer's soluble amyloid beta is a normal component of human urine.
FEBS letters 1997;408(1):105-8.
1997: Wisniewski T; Ghiso J; Frangione B
Biology of A beta amyloid in Alzheimer's disease.
Neurobiology of disease 1997;4(5):313-28.
1996: Lalowski M; Golabek A; Lemere C A; Selkoe D J; Wisniewski H M; Beavis R C; Frangione B; Wisniewski T
The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.
The Journal of biological chemistry 1996;271(52):33623-31.
1996: Garzuly F; Vidal R; Wisniewski T; Brittig F; Budka H
Familial meningocerebrovascular amyloidosis, Hungarian type, with mutant transthyretin (TTR Asp18Gly)
Neurology 1996;47(6):1562-7.
1996: Vidal R; Ghiso J; Wisniewski T; Frangione B
Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant.
FEBS letters 1996;393(1):19-23.
1996: Baumann M; Golabek A; Lalowski M; Wisniewski T
Micropreparative gel electrophoresis of low-molecular-weight peptides: purification of highly insoluble amyloid peptide fragments.
Analytical biochemistry 1996;236(2):191-8.
1996: Golabek A A; Soto C; Vogel T; Wisniewski T
The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation.
The Journal of biological chemistry 1996;271(18):10602-6.
1996: Lemere C A; Blusztajn J K; Yamaguchi H; Wisniewski T; Saido T C; Selkoe D J
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
Neurobiology of disease 1996;3(1):16-32.
1996: Palha J A; Moreira P; Wisniewski T; Frangione B; Saraiva M J
Transthyretin gene in Alzheimer's disease patients.
Neuroscience letters 1996;204(3):212-4.
1996: Soto C; Golabek A; Wisniewski T; Castaño E M
Alzheimer's beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro.
Neuroreport 1996;7(3):721-5.
1996: Baumann M H; Wisniewski T; Levy E; Plant G T; Ghiso J
C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type.
Biochemical and biophysical research communications 1996;219(1):238-42.
1996: Vidal R; Garzuly F; Budka H; Lalowski M; Linke R P; Brittig F; Frangione B; Wisniewski T
Meningocerebrovascular amyloidosis associated with a novel transthyretin mis-sense mutation at codon 18 (TTRD 18G)
The American journal of pathology 1996;148(2):361-6.
1996: Wisniewski T; Lalowski M; Baumann M; Rauvala H; Raulo E; Nolo R; Frangione B
HB-GAM is a cytokine present in Alzheimer's and Down's syndrome lesions.
Neuroreport 1996;7(2):667-71.
1996: Wisniewski T; Lalowski M; Bobik M; Russell M; Strosznajder J; Frangione B
Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs.
The Biochemical journal 1996;313 ( Pt 2)():575-80.
1996: Frangione B; Castaño E M; Wisniewski T; Ghiso J; Prelli F; Vidal R
Apolipoprotein E and amyloidogenesis.
Ciba Foundation symposium 1996;199():132-41; discussion 141-5.
1996: Wisniewski T; Frangione B
Molecular biology of brain aging and neurodegenerative disorders.
Acta neurobiologiae experimentalis 1996;56(1):267-79.
1995: Wisniewski T; Palha J A; Ghiso J; Frangione B
S182 protein in Alzheimer's disease neuritic plaques.
Lancet 1995;346(8986):1366.
1995: Wisniewski T; Frangione B
Amyloidosis in Alzheimer's disease.
Lancet 1995;346(8972):441.
1995: Wisniewski T; Golabek A A; Kida E; Wisniewski K E; Frangione B
Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis.
The American journal of pathology 1995;147(2):238-44.
1995: Golabek A; Marques M A; Lalowski M; Wisniewski T
Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid.
Neuroscience letters 1995;191(1-2):79-82.
1995: Wisniewski T; Lalowski M; Golabek A; Vogel T; Frangione B
Is Alzheimer's disease an apolipoprotein E amyloidosis?
Lancet 1995;345(8955):956-8.
1995: Ghiso J; Plant G T; Révész T; Wisniewski T; Frangione B
Familial cerebral amyloid angiopathy (British type) with nonneuritic amyloid plaque formation may be due to a novel amyloid protein.
Journal of the neurological sciences 1995;129(1):74-5.
1995: Castano E M; Prelli F; Wisniewski T; Golabek A; Kumar R A; Soto C; Frangione B
Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.
The Biochemical journal 1995;306 ( Pt 2)():599-604.
1995: Wisniewski T; Morelli L; Wegiel J; Levy E; Wisniewski H M; Frangione B
The influence of apolipoprotein E isotypes on Alzheimer's disease pathology in 40 cases of Down's syndrome.
Annals of neurology 1995;37(1):136-8.
1995: Mangone C A; Castaño E M; Levy E; Abiusi G; Wisniewski T; Marques M R; Faccio E; Gorelick P B; Frangione B; Sica R E
Early onset Alzheimer's disease in a South American pedigree from Argentina.
Acta neurologica Scandinavica 1995;91(1):6-13.
1994: Zlokovic B V; Martel C L; Mackic J B; Matsubara E; Wisniewski T; McComb J G; Frangione B; Ghiso J
Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta.
Biochemical and biophysical research communications 1994;205(2):1431-7.
1994: Wisniewski T; Castaño E M; Golabek A; Vogel T; Frangione B
Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.
The American journal of pathology 1994;145(5):1030-5.
1994: Gallo G; Wisniewski T; Choi-Miura N H; Ghiso J; Frangione B
Potential role of apolipoprotein-E in fibrillogenesis.
The American journal of pathology 1994;145(3):526-30.
1994: Sanan D A; Weisgraber K H; Russell S J; Mahley R W; Huang D; Saunders A; Schmechel D; Wisniewski T; Frangione B; Roses A D
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.
The Journal of clinical investigation 1994;94(2):860-9.
1994: Wisniewski T; Ghiso J; Frangione B
Alzheimer's disease and soluble A beta.
Neurobiology of aging 1994;15(2):143-52.
1994: Kida E; Golabek A A; Wisniewski T; Wisniewski K E
Regional differences in apolipoprotein E immunoreactivity in diffuse plaques in Alzheimer's disease brain.
Neuroscience letters 1994;167(1-2):73-6.
1994: Wisniewski T; Lalowski M; Levy E; Marques M R; Frangione B
The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient.
Annals of neurology 1994;35(2):245-6.
1994: Ghiso J; Wisniewski T; Frangione B
Unifying features of systemic and cerebral amyloidosis.
Molecular neurobiology 1994;8(1):49-64.
1994: Frangione B; Wisniewski T; Ghiso J
Chaperoning Alzheimer's amyloids.
Neurobiology of aging 1994;15 Suppl 2():S97-9.
1993: Wisniewski T; Castano E; Ghiso J; Frangione B
Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.
Annals of neurology 1993;34(4):631-3.
1993: Ghiso J; Matsubara E; Koudinov A; Choi-Miura N H; Tomita M; Wisniewski T; Frangione B
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
The Biochemical journal 1993;293 ( Pt 1)():27-30.
1993: Rodrigues M M; Rajagopalan S; Jones K; Nirankari V; Wisniewski T; Frangione B; Gorevic P D
Gelsolin immunoreactivity in corneal amyloid, wound healing, and macular and granular dystrophies.
American journal of ophthalmology 1993;115(5):644-52.
1993: Wisniewski T; Golabek A; Matsubara E; Ghiso J; Frangione B
Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid.
Biochemical and biophysical research communications 1993;192(2):359-65.
1992: Ghiso J; Wisniewski T; Vidal R; Rostagno A; Frangione B
Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease.
The Biochemical journal 1992;282 ( Pt 2)():517-22.
1992: Iwaki T; Wisniewski T; Iwaki A; Corbin E; Tomokane N; Tateishi J; Goldman J E
Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions.
The American journal of pathology 1992;140(2):345-56.
1992: Wisniewski T; Frangione B
Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid.
Neuroscience letters 1992;135(2):235-8.
1992: Constantinidis J; Wisniewski K E; Wisniewski T M
The adult and a new late adult forms of neuronal ceroid lipofuscinosis.
Acta neuropathologica 1992;83(5):461-8.
1992: Wisniewski T; Frangione B
Molecular biology of Alzheimer's amyloid--Dutch variant.
Molecular neurobiology 1992;6(1):75-86.
1991: Wisniewski T; Ghiso J; Frangione B
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications 1991;180(3):1528.
1991: Castaño E M; Wisniewski T; Frangione B
Inherited amyloids of the nervous system.
Current opinion in neurobiology 1991;1(3):448-54.
1991: Wisniewski T; Ghiso J; Frangione B
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications 1991;179(3):1247-54.
1991: Haltia M; Ghiso J; Wisniewski T; Kiuru S; Miller D; Frangione B
Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies.
Neurobiology of aging 1991;12(4):313-6.
1991: Wisniewski T; Haltia M; Ghiso J; Frangione B
Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type.
The American journal of pathology 1991;138(5):1077-83.
1991: Constantinidis J; Wisniewski T M
The dominant form of the pigmentary orthochromatic leukodystrophy.
Acta neuropathologica 1991;82(6):483-7.
1990: Wisniewski T; Sisti M; Inhirami G; Knowles D M; Powers J M
Intracerebral solitary plasmacytoma.
Neurosurgery 1990;27(5):826-9; discussion 829.
1990: Onesti S T; Wisniewski T; Post K D
Pituitary hemorrhage into a Rathke's cleft cyst.
Neurosurgery 1990;27(4):644-6.
1990: Onesti S T; Wisniewski T; Post K D
Clinical versus subclinical pituitary apoplexy: presentation, surgical management, and outcome in 21 patients.
Neurosurgery 1990;26(6):980-6.
1990: Kitaguchi T; Wisniewski K E; Maslinski S; Maslinska D; Wisniewski T M; Kim K S
Beta-protein immunoreactivity in brains of patients with neuronal ceroid lipofuscinosis: ultrastructural and biochemical demonstration.
Neuroscience letters 1990;112(2-3):155-60.
1981: Moon H M; Wisniewski T; Merz P; De Martini J; Wisniewski H M
Partial purification of neurofilament subunits from bovine brains and studies on neurofilament assembly.
The Journal of cell biology 1981;89(3):560-7.

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