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Thomas Wisniewski

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Jerzy Wegiel; Jarek Wegiel; Shuang Yong Ma; Efrain C Azmitia; Probal Banerjee; Ira L Cohen; Michael Flory; Humi Imaki; Carolyn Komich Hare; Izabela Kuchna; Eric London; Krzysztof Nowicki; W Ted Brown; Thomas Wisniewski
Contribution of olivofloccular circuitry developmental defects to atypical gaze in autism.
Youssef Wadghiri; Andrew Wang; Jinhuan Wang; Allal Boutajangout; Mony J de Leon; Dung Minh Hoang; Jialin Li; Yongsheng Li; Yanjie Sun; Wai Tsui; Hong Xu; Thomas Wisniewski
Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer's disease transgenic mice using magnetic resonance microimaging.
Thomas Wisniewski; Kia Newman; Norman B Javitt
Alzheimer's disease: brain desmosterol levels.

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All Publications

2013: Jerzy Wegiel; Jarek Wegiel; Shuang Yong Ma; Efrain C Azmitia; Probal Banerjee; Ira L Cohen; Michael Flory; Humi Imaki; Carolyn Komich Hare; Izabela Kuchna; Eric London; Krzysztof Nowicki; W Ted Brown; Thomas Wisniewski
Contribution of olivofloccular circuitry developmental defects to atypical gaze in autism.
Brain research 2013;1512():106-22.
2013: Youssef Wadghiri; Andrew Wang; Jinhuan Wang; Allal Boutajangout; Mony J de Leon; Dung Minh Hoang; Jialin Li; Yongsheng Li; Yanjie Sun; Wai Tsui; Hong Xu; Thomas Wisniewski
Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer's disease transgenic mice using magnetic resonance microimaging.
PloS one 2013;8(2):e57097.
2013: Thomas Wisniewski; Kia Newman; Norman B Javitt
Alzheimer's disease: brain desmosterol levels.
Journal of Alzheimer's disease : JAD 2013;33(3):881-8.
2012: Thomas Wisniewski
Active immunotherapy for Alzheimer's disease.
Lancet neurology 2012;11(7):571-2.
2012: Jerzy Wegiel; Jarek Wegiel; Teresa Wierzba-Bobrowicz; W Ted Brown; Abha Chauhan; Ved Chauhan; Ira L Cohen; Edwin H Cook; Michael Flory; Humi Imaki; Izabela Kuchna; Boleslaw Lach; Eric London; Shuang Yong Ma; Elaine Marchi; Krzysztof Nowicki; N Carolyn Schanen; Marian Sigman; Thomas Wisniewski
Differences between the pattern of developmental abnormalities in autism associated with duplications 15q11.2-q13 and idiopathic autism.
Journal of neuropathology and experimental neurology 2012;71(5):382-97.
2012: Thomas Wisniewski; Fernando Goñi
Could immunomodulation be used to prevent prion diseases?
Expert review of anti-infective therapy 2012;10(3):307-17.
2012: María C Leal; Eduardo M Castaño; Carina C Ferrari; María P Holgado; Fernando J Pitossi; Ezequiel I Surace; Rodolfo Tarelli; Thomas Wisniewski; Laura Morelli
Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism.
Biochimica et biophysica acta 2012;1823(2):227-35.
2012: Jerzy Wegiel; W Ted Brown; Abha Chauhan; Ved Chauhan; Ira L Cohen; Edwin H Cook; Mony J de Leon; Michael Flory; Janusz Frackowiak; Humi Imaki; Izabela Kuchna; Eric London; Shuang Yong Ma; Bozena Mazur-Kolecka; Pankaj D Mehta; David L Miller; Krzysztof Nowicki; Barry Reisberg; N Carolyn Schanen; Marian Sigman; Jarek Wegiel; Thomas Wisniewski
Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders.
PloS one 2012;7(5):e35414.
2012: Youssef Wadghiri; Thomas Wisniewski; Dung Minh Hoang; Einar Sigurdsson
In vivo magnetic resonance imaging of amyloid-β plaques in mice.
Methods in molecular biology (Clifton, N.J.) 2012;849():435-51.
2011: Jing Yang; Youssef Wadghiri; Dung Minh Hoang; Wai Tsui; Yanjie Sun; Erika Chung; Yongsheng Li; Andrew Wang; Mony J de Leon; Thomas Wisniewski
Detection of amyloid plaques targeted by USPIO-Aβ1-42 in Alzheimer's disease transgenic mice using magnetic resonance microimaging.
NeuroImage 2011;55(4):1600-9.
2011: Suying Dang; Tao Hong; Thomas Wisniewski; Wei Zhang
Dissolution of pre-existing platelet thrombus by synergistic administration of low concentrations of bifunctional antibodies against β3 integrin.
PloS one 2011;6(10):e27012.
2011: Erika Chung; Stephen Dealler; Woo Sirl Lee; Frances Prelli; Young-Tae Chang; Thomas Wisniewski
Styryl-based and tricyclic compounds as potential anti-prion agents.
PloS one 2011;6(9):e24844.
2011: Ekambar R Kandimalla; Tao Lan; Melissa Precopio; Mary Struthers; Zhenhua Sun; Hao Wang; Thomas Wisniewski; Sudhir Agrawal; Andrew J Bett; Sheri A Dubey; Weiwen Jiang; Danilo R Casimiro
Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists.
Cellular immunology 2011;270(2):126-34.
2011: Jing Yang; Yong Ji; Pankaj Mehta; Kristyn Bates; Yanjie Sun; Thomas Wisniewski
Blocking the apolipoprotein E/amyloid-β interaction reduces fibrillar vascular amyloid deposition and cerebral microhemorrhages in TgSwDI mice.
Journal of Alzheimer's disease : JAD 2011;24(2):269-85.
2011: Jerzy Wegiel; Wojciech Kaczmarski; Madhabi Barua; Izabela Kuchna; Krzysztof Nowicki; Kuo-Chiang Wang; Jarek Wegiel; Shuang Ma Yang; Janusz Frackowiak; Bozena Mazur-Kolecka; WAYNE SILVERMAN; Barry Reisberg; Isabel Monteiro; Mony J de Leon; Thomas Wisniewski; Arthur Dalton; Florence Lai; Yu-Wen Hwang; Tatyana Adayev; Fei Liu; Khalid Iqbal; Inge-Grundke Iqbal; Cheng-Xin Gong
Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome.
Journal of neuropathology and experimental neurology 2011;70(1):36-50.
2010: Thomas Wisniewski; Fernando Goñi
Immunomodulation for prion and prion-related diseases.
Expert review of vaccines 2010;9(12):1441-52.
2010: Thomas Wisniewski; Einar Sigurdsson
Murine models of Alzheimer's disease and their use in developing immunotherapies.
Biochimica et biophysica acta 2010;1802(10):847-59.
2010: Wei Zhang; Yong-Sheng Li; Michael A Nardi; Suying Dang; Jing Yang; Yong Ji; Zongdong Li; Simon Karpatkin; Thomas Wisniewski
Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus.
Blood 2010;116(13):2336-44.
2010: Jerzy Wegiel; Izabela Kuchna; Krzysztof Nowicki; Humi Imaki; Jarek Wegiel; Elaine Marchi; Shuang Yong Ma; Abha Chauhan; Ved Chauhan; Teresa Wierzba Bobrowicz; Mony J de Leon; Leslie A Saint Louis; Ira L Cohen; Eric London; W Ted Brown; Thomas Wisniewski
The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes.
Acta neuropathologica 2010;119(6):755-70.
2010: Thomas Wisniewski; Allal Boutajangout
Immunotherapeutic approaches for Alzheimer's disease in transgenic mouse models.
Brain structure & function 2010;214(2-3):201-18.
2010: Fernando Goñi; Frances Prelli; Yong Ji; Henrieta Scholtzova; Jing Yang; Yanjie Sun; Feng-Xia Liang; Richard J Kascsak; Richard Kascsak; Pankaj Mehta; Thomas Wisniewski
Immunomodulation targeting abnormal protein conformation reduces pathology in a mouse model of Alzheimer's disease.
PloS one 2010;5(10):e13391.
2010: Erika Chung; Yong Ji; Yanjie Sun; Richard J Kascsak; Regina B Kascsak; Pankaj D Mehta; Stephen M Strittmatter; Thomas Wisniewski
Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse.
BMC neuroscience 2010;11():130.
2010: Mary Struthers; Andrew J Bett; Thomas Wisniewski; Sheri A Dubey; Melissa Precopio; Weiwen Jiang; Zhenhua Sun; Hao Wang; Ireneusz Nowak; Mallikarjuna R Putta; Dong Yu; Jimmy X Tang; Ekambar R Kandimalla; Sudhir Agrawal; Danilo R Casimiro
Synthesis and immunological activities of novel agonists of toll-like receptor 9.
Cellular immunology 2010;263(1):105-13.
2010: Thomas Wisniewski; Allal Boutajangout
Vaccination as a therapeutic approach to Alzheimer's disease.
The Mount Sinai journal of medicine, New York 2010;77(1):17-31.
2009: Martin Sadowski; Joanna Pankiewicz; Frances Prelli; Henrieta Scholtzova; Daryl Spinner; Regina B Kascsak; Richard J Kascsak; Thomas Wisniewski
Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo.
Neurobiology of disease 2009;34(2):267-78.
2009: Lisa Mosconi; Rachel Mistur; Remigiusz Switalski; Wai Hon Tsui; Lidia Glodzik; Yi Li; Elizabeth Pirraglia; Susan De Santi; Barry Reisberg; Thomas Wisniewski; Mony J de Leon
FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease.
European journal of nuclear medicine and molecular imaging 2009;36(5):811-22.
2009: Thomas Wisniewski
AD vaccines: conclusions and future directions.
CNS & neurological disorders drug targets 2009;8(2):160-6.
2009: Jiong Zhan; Miroslaw Brys; Lidia Glodzik; Wai Hon Tsui; Elizabeth Javier; Jerzy Wegiel; Izabela Kuchna; Elizabeth Pirraglia; Yi Li; Lisa Mosconi; LA Saint Louis; Remigiusz Switalski; Susan De Santi; Byeong C Kim; Thomas Wisniewski; Barry Reisberg; Matthew Bobinski; Mony J de Leon
An entorhinal cortex sulcal pattern is associated with Alzheimer's disease.
Human brain mapping 2009;30(3):874-82.
2009: Henrieta Scholtzova; Richard J Kascsak; Kristyn Bates; Allal Boutajangout; Daniel J Kerr; Harry C Meeker; Pankaj D Mehta; Daryl Spinner; Thomas Wisniewski
Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's disease-related pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(6):1846-54.
2009: Stéphanie G Trouche; Ayodeji Asuni; Sylvie Rouland; Thomas Wisniewski; Blas Frangione; Jean-Michel Verdier; Einar Sigurdsson; Nadine Mestre-Francés
Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives.
Vaccine 2009;27(7):957-64.
2009: Allal Boutajangout; Fernando Goni; Elin Knudsen; Fernanda Schreiber; Ayodeji Asuni; David Quartermain; Blas Frangione; Alejandro Chabalgoity; Thomas Wisniewski; Einar Sigurdsson
Diminished amyloid-beta burden in Tg2576 mice following a prophylactic oral immunization with a salmonella-based amyloid-beta derivative vaccine.
Journal of Alzheimer's disease : JAD 2009;18(4):961-72.
2008: Daryl Spinner; In Soo Cho; Seung Yong Park; Jae Il Kim; Harry C Meeker; Xuemin Ye; Giuseppe LaFauci; Daniel J Kerr; Michael J Flory; Bo Sook Kim; Regina B Kascsak; Thomas Wisniewski; William R Levis; Georgia B Schuller-Levis; Richard I Carp; Eunkyue Park; Richard J Kascsak
Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice.
Journal of virology 2008;82(21):10701-8.
2008: Jerzy Wegiel; Karol Dowjat; Wojciech Kaczmarski; Izabela Kuchna; Krzysztof Nowicki; Janusz Frackowiak; Bozena Mazur-Kolecka; Jarek Wegiel; WAYNE SILVERMAN; Barry Reisberg; Mony Deleon; Thomas Wisniewski; Cheng-Xin Gong; Fei Liu; Tatyana Adayev; Mo-Chou Chen-Hwang; Yu-Wen Hwang
The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome.
Acta neuropathologica 2008;116(4):391-407.
2008: Steven Cercy; Martin Sadowski; Thomas Wisniewski
Prominent neuroleptic sensitivity in a case of early-onset Alzheimer disease due to presenilin-1 G206A mutation.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology 2008;21(3):190-5.
2008: Thomas Wisniewski; Uwe Konietzko
Amyloid-beta immunisation for Alzheimer's disease.
Lancet neurology 2008;7(9):805-11.
2008: Henrieta Scholtzova; Youssef Wadghiri; Moustafa Douadi; Einar Sigurdsson; Yong-Sheng Li; David Quartermain; Pradeep Banerjee; Thomas Wisniewski
Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging.
Journal of neuroscience research 2008;86(12):2784-91.
2008: Pierluigi Gambetti; Zhiqian Dong; Jue Yuan; Xiangzhu Xiao; Mengjie Zheng; Amer Alshekhlee; Rudy J Castellani; Mark Cohen; Marcelo A Barria; D Gonzalez-Romero; Ermias D Belay; Lawrence B Schonberger; Karen Marder; Carrie Harris; James R Burke; Thomas J Montine; Thomas Wisniewski; dennis dickson; Claudio Soto; Christine M Hulette; James A Mastrianni; Qingzhong Kong; Wen-Quan Zou
A novel human disease with abnormal prion protein sensitive to protease.
Annals of neurology 2008;63(6):697-708.
2008: Einar Sigurdsson; Youssef Wadghiri; Lisa Mosconi; Jeffrey A Blind; Elin Knudsen; Ayodeji A Asuni; Henrieta Scholtzova; Wai Hon Tsui; Yongsheng Li; Martin Sadowski; Daniel Turnbull; Mony J de Leon; Thomas Wisniewski
A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice.
Neurobiology of aging 2008;29(6):836-47.
2008: F Goñi; Frances Prelli; Fernanda Schreiber; Henrieta Scholtzova; E Chung; Richard J Kascsak; David Brown; Einar Sigurdsson; José A Chabalgoity; Thomas Wisniewski
High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice.
Neuroscience 2008;153(3):679-86.
2008: Igor Klyubin; Vicki Betts; Alfred T Welzel; Kaj Blennow; Henrik Zetterberg; Anders Wallin; Cynthia A Lemere; William K Cullen; Ying Peng; Thomas Wisniewski; Dennis J Selkoe; Roger Anwyl; Dominic M Walsh; Michael J Rowan
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(16):4231-7.
2008: Omidreza Firuzi; Jiamin Zhuo; Cinzia M Chinnici; Thomas Wisniewski; Domenico Pratico'
5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(4):1169-78.
2008: Thomas Wisniewski; Martin Sadowski
Preventing beta-amyloid fibrillization and deposition: beta-sheet breakers and pathological chaperone inhibitors.
BMC neuroscience 2008;9 Suppl 2():S5.
2007: Sarah Webb; Tamuna Lekishvili; Corinna Loeschner; Shane Sellarajah; Frances Prelli; Thomas Wisniewski; Ian H Gilbert; David Brown
Mechanistic insights into the cure of prion disease by novel antiprion compounds.
Journal of virology 2007;81(19):10729-41.
2007: Qian Li; Jaeki Min; Young-Hoon Ahn; Joshua Namm; Eun Min Kim; Rowena Lui; Hye Yun Kim; Yong Ji; Hueizhi Wu; Thomas Wisniewski; Young-Tae Chang
Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques.
Chembiochem : a European journal of chemical biology 2007;8(14):1679-87.
2007: Thomas Wisniewski; Einar Sigurdsson
Therapeutic approaches for prion and Alzheimer's diseases.
The FEBS journal 2007;274(15):3784-98.
2007: Claudia M Litterst; Anastasios Georgakopoulos; Junichi Shioi; Enrico Ghersi; Thomas Wisniewski; Rong Wang; Andreas Ludwig; Nikolaos K Robakis
Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.
The Journal of biological chemistry 2007;282(22):16155-63.
2007: Daryl Spinner; Regina B Kascsak; Giuseppe LaFauci; Harry C Meeker; Xuemin Ye; Michael J Flory; Jae Il Kim; Georgia B Schuller-Levis; William R Levis; Thomas Wisniewski; Richard I Carp; Richard J Kascsak
CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils.
Journal of leukocyte biology 2007;81(6):1374-85.
2007: Thomas Wisniewski; José A Chabalgoity; F Goni
Is vaccination against transmissible spongiform encephalopathy feasible?
Revue scientifique et technique (International Office of Epizootics) 2007;26(1):243-51.
2007: Jerzy Wegiel; Izabela Kuchna; Krzysztof Nowicki; Janusz Frackowiak; Bozena Mazur-Kolecka; Humi Imaki; Jarek Wegiel; Pankaj D Mehta; WAYNE SILVERMAN; Barry Reisberg; Mony Deleon; Thomas Wisniewski; Tuula Pirttilla; Harry Frey; Terho Lehtimäki; Tarmo Kivimäki; Frank E Visser; Wouter Kamphorst; Anna Potempska; David Bolton; Julia R Currie; David L Miller
Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration.
Acta neuropathologica 2007;113(4):389-402.
2007: Anthony B Pinkerton; Dehua Huang; Rowena V Cube; John H Hutchinson; Mary Struthers; Julia Ayala; Pasquale P Vicario; Sima R Patel; Thomas Wisniewski; Julie A DeMartino; Jean-Michel Vernier
Diaryl substituted pyrazoles as potent CCR2 receptor antagonists.
Bioorganic & medicinal chemistry letters 2007;17(3):807-13.
2007: Martin Sadowski; Thomas Wisniewski
Disease modifying approaches for Alzheimer's pathology.
Current pharmaceutical design 2007;13(19):1943-54.
2007: Binggong Chang; Xin Cheng; Shaoman Yin; Tao Pan; Hongtao Zhang; Poki Wong; Shin-Chung Kang; Fan Xiao; Huimin Yan; Chaoyang Li; Lisa L Wolfe; Michael W Miller; Thomas Wisniewski; Mark I Greene; Man-Sun Sy
Test for detection of disease-associated prion aggregate in the blood of infected but asymptomatic animals.
Clinical and vaccine immunology : CVI 2007;14(1):36-43.
2006: Martin Sadowski; Joanna Pankiewicz; Henrieta Scholtzova; Pankaj D Mehta; Frances Prelli; David Quartermain; Thomas Wisniewski
Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18787-92.
2006: Ayodeji A Asuni; Allal Boutajangout; Henrieta Scholtzova; Elin Knudsen; Yong Sheng Li; David Quartermain; Blas Frangione; Thomas Wisniewski; Einar Sigurdsson
Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages.
The European journal of neuroscience 2006;24(9):2530-42.
2006: María C Leal; Verónica B Dorfman; Agata Fernández Gamba; Blas Frangione; Thomas Wisniewski; Eduardo M Castaño; Einar Sigurdsson; Laura Morelli
Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology.
Journal of neuropathology and experimental neurology 2006;65(10):976-87.
2006: Joanna Pankiewicz; Frances Prelli; Man-Sun Sy; Richard J Kascsak; Regina B Kascsak; Daryl Spinner; Richard I Carp; Harry C Meeker; Martin Sadowski; Thomas Wisniewski
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.
The European journal of neuroscience 2006;23(10):2635-47.
2005: Einar Sigurdsson; Thomas Wisniewski
Promising developments in prion immunotherapy.
Expert review of vaccines 2005;4(5):607-10.
2005: Tao Pan; Binggong Chang; Poki Wong; Chaoyang Li; Ruliang Li; Shin-Chung Kang; John D Robinson; Andrew R Thompsett; Po Tein; Shaoman Yin; Geoff Barnard; Irene McConnell; David Brown; Thomas Wisniewski; Man-Sun Sy
An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates.
Journal of virology 2005;79(19):12355-64.
2005: Judyth Sassoon; Martin Sadowski; Thomas Wisniewski; David Brown
Therapeutics and prion disease: can immunisation or drugs be effective?
Mini reviews in medicinal chemistry 2005;5(4):361-6.
2005: Youssef Wadghiri; Einar Sigurdsson; Thomas Wisniewski; Daniel Turnbull
Magnetic resonance imaging of amyloid plaques in transgenic mice.
Methods in molecular biology (Clifton, N.J.) 2005;299():365-79.
2005: F Goñi; Elin Knudsen; Fernanda Schreiber; Henrieta Scholtzova; Joanna Pankiewicz; Richard I Carp; Harry C Meeker; Richard Rubenstein; David Brown; Man-Sun Sy; José A Chabalgoity; Einar Sigurdsson; Thomas Wisniewski
Mucosal vaccination delays or prevents prion infection via an oral route.
Neuroscience 2005;133(2):413-21.
2005: Thomas Wisniewski; Blas Frangione
Immunological and anti-chaperone therapeutic approaches for Alzheimer disease.
Brain pathology (Zurich, Switzerland) 2005;15(1):72-7.
2005: Tao Pan; Poki Wong; Binggong Chang; Chaoyang Li; Ruliang Li; Shin-Chung Kang; Thomas Wisniewski; Man-Sun Sy
Biochemical fingerprints of prion infection: accumulations of aberrant full-length and N-terminally truncated PrP species are common features in mouse prion disease.
Journal of virology 2005;79(2):934-43.
2004: Jorge Ghiso; Thomas Wisniewski
An animal model of vascular amyloidosis.
Nature neuroscience 2004;7(9):902-4.
2004: Martin Sadowski; Joanna Pankiewicz; Henrieta Scholtzova; James A Ripellino; Yongsheng Li; Stephen D Schmidt; Paul Mathews; John D Fryer; David M Holtzman; Einar Sigurdsson; Thomas Wisniewski
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.
The American journal of pathology 2004;165(3):937-48.
2004: Tao Pan; Ruliang Li; Shin-Chung Kang; Boon-Seng Wong; Thomas Wisniewski; Man-Sun Sy
Epitope scanning reveals gain and loss of strain specific antibody binding epitopes associated with the conversion of normal cellular prion to scrapie prion.
Journal of neurochemistry 2004;90(5):1205-17.
2004: Einar Sigurdsson; Elin Knudsen; Ayodeji A Asuni; Cheryl Fitzer-Attas; Daniel Sage; David Quartermain; Fernando Goni; Blas Frangione; Thomas Wisniewski
An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(28):6277-82.
2004: Martin Sadowski; Joanna Pankiewicz; Henrieta Scholtzova; Julia Tsai; Yongsheng Li; Richard I Carp; Harry C Meeker; Pierluigi Gambetti; Manik L Debnath; Chester A Mathis; Li Shao; Wen-Biao Gan; William E Klunk; Thomas Wisniewski
Targeting prion amyloid deposits in vivo.
Journal of neuropathology and experimental neurology 2004;63(7):775-84.
2004: Jerzy Wegiel; Izabela Kuchna; Krzysztof Nowicki; Janusz Frackowiak; Karol Dowjat; WAYNE SILVERMAN; Barry Reisberg; Mony DeLeon; Thomas Wisniewski; Tatyana Adayev; Mo-Chou Chen-Hwang; Yu-Wen Hwang
Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain.
Brain research 2004;1010(1-2):69-80.
2004: Martin Sadowski; Thomas Wisniewski
Vaccines for conformational disorders.
Expert review of vaccines 2004;3(3):279-90.
2004: Martin Sadowski; Joanna Pankiewicz; Henrieta Scholtzova; Yong-sheng Li; David Quartermain; karen duff; Thomas Wisniewski
Links between the pathology of Alzheimer's disease and vascular dementia.
Neurochemical research 2004;29(6):1257-66.
2004: Martin Sadowski; Joanna Pankiewicz; Henrieta Scholtzova; Yong Ji; David Quartermain; Catrin H Jensen; karen duff; Ralph A. Nixon; Rand J Gruen; Thomas Wisniewski
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.
Journal of neuropathology and experimental neurology 2004;63(5):418-28.
2004: Shin-Chung Kang; David Brown; Matthew Whiteman; Ruliang Li; Tao Pan; George Perry; Thomas Wisniewski; Man-Sun Sy; Boon-Seng Wong
Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice.
The Journal of pathology 2004;203(1):603-8.
2004: Joseph A Helpern; Sang-Pil Lee; Maria F Falangola; Victor V Dyakin; Adam Bogart; Babak A Ardekani; karen duff; Craig A Branch; Thomas Wisniewski; Mony J de Leon; Oliver T Wolf; Jacqueline O'Shea; Ralph A. Nixon
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(4):794-8.
2004: Wieslaw K Dowjat; Izabela Kuchna; Thomas Wisniewski; Jerzy Wegiel
A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations.
Journal of Alzheimer's disease : JAD 2004;6(1):31-43.
2003: Einar Sigurdsson; David Brown; Muhammad A Alim; Henrieta Scholtzova; Richard I Carp; Harry C Meeker; Frances Prelli; Blas Frangione; Thomas Wisniewski
Copper chelation delays the onset of prion disease.
The Journal of biological chemistry 2003;278(47):46199-202.
2003: Youssef Wadghiri; Einar Sigurdsson; Martin Sadowski; James I Elliott; Yongsheng Li; Henrieta Scholtzova; Cheuk Tang; Gilbert Aguinaldo; Miguel Pappolla; karen duff; Thomas Wisniewski; Daniel Turnbull
Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;50(2):293-302.
2003: Martin Sadowski; Cheuk Tang; Juan Gilberto S Aguinaldo; Richard I Carp; Harry C Meeker; Thomas Wisniewski
In vivo micro magnetic resonance imaging signal changes in scrapie infected mice.
Neuroscience letters 2003;345(1):1-4.
2003: Boon-Seng Wong; Ruliang Li; Judyth Sassoon; Shin-Chung Kang; Tong Liu; Tao Pan; Neil S Greenspan; Thomas Wisniewski; David Brown; Man-Sun Sy
Mapping the antigenicity of copper-treated cellular prion protein with the scrapie isoform.
Cellular and molecular life sciences : CMLS 2003;60(6):1224-34.
2003: Einar Sigurdsson; Man-Sun Sy; Ruliang Li; Henrieta Scholtzova; Richard J Kascsak; Regina Kascsak; Richard I Carp; Harry C Meeker; Blas Frangione; Thomas Wisniewski
Anti-prion antibodies for prophylaxis following prion exposure in mice.
Neuroscience letters 2003;336(3):185-7.
2003: Y Ji; Y Gong; Wen-Biao Gan; Thomas Beach; David M Holtzman; Thomas Wisniewski
Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients.
Neuroscience 2003;122(2):305-15.
2002: Mony J de Leon; S Segal; Chaim Y Tarshish; Susan Desanti; Raymond Zinkowski; Pankaj D Mehta; Antonio Convit; Conrado Caraos; Henry Rusinek; Wai Hon Tsui; LA Saint Louis; John DeBernardis; Daniel Kerkman; F Qadri; A Gary; P Lesbre; Thomas Wisniewski; J Poirier; Peter Davies
Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment.
Neuroscience letters 2002;333(3):183-6.
2002: Joseph F. Poduslo; Thomas M Wengenack; Geoffry L Curran; Thomas Wisniewski; Einar Sigurdsson; Slobodon I Macura; Bret J Borowski; Clifford R Jack
Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.
Neurobiology of disease 2002;11(2):315-29.
2002: Einar Sigurdsson; Thomas Wisniewski; Blas Frangione
A safer vaccine for Alzheimer's disease?
Neurobiology of aging 2002;23(6):1001-8.
2002: Einar Sigurdsson; Thomas Wisniewski; Blas Frangione
Infectivity of amyloid diseases.
Trends in molecular medicine 2002;8(9):411-3.
2002: Thomas Wisniewski; Einar Sigurdsson
Immunization treatment approaches in Alzheimer's and prion diseases.
Current neurology and neuroscience reports 2002;2(5):400-4.
2002: Thomas Wisniewski; David Brown; Einar Sigurdsson
Therapeutics in Alzheimer's and prion diseases.
Biochemical Society transactions 2002;30(4):574-8.
2002: Einar Sigurdsson; David Brown; Maki Daniels; Richard J Kascsak; Regina Kascsak; Richard I Carp; Harry C Meeker; Blas Frangione; Thomas Wisniewski
Immunization delays the onset of prion disease in mice.
The American journal of pathology 2002;161(1):13-7.
2002: Jasmina B Mackic; James R Bading; Jorge Ghiso; Larry Walker; Thomas Wisniewski; Blas Frangione; Berislav V Zlokovic
Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions.
Vascular pharmacology 2002;38(6):303-13.
2002: Chica Mori; Edward T Spooner; Krystyna E Wisniewsk; Thomas Wisniewski; Haruyasu Yamaguch; Takaom C Saido; Dean R Tolan; Dennis J Selkoe; Cynthia A Lemere
Intraneuronal Abeta42 accumulation in Down syndrome brain.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2002;9(2):88-102.
2002: Paul H Wen; Xiang Shao; Zhiping Shao; Patrick R Hof; Thomas Wisniewski; Kevin Kelley; Victor L Friedrich; Lap Ho; Giulio Maria Pasinetti; Junichi Shioi; Nikolaos K Robakis; Gregory A Elder
Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice.
Neurobiology of disease 2002;10(1):8-19.
2002: Philippe Marambaud; Junichi Shioi; Geo Serban; Anastasios Georgakopoulos; Shula Sarner; Vanja Nagy; Lia Baki; Paul Wen; Spiros Efthimiopoulos; Zhiping Shao; Thomas Wisniewski; Nikolaos K Robakis
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.
The EMBO journal 2002;21(8):1948-56.
2002: Jerzy Wegiel; Izabela Kuchna; Thomas Wisniewski; Mony J de Leon; Barry Reisberg; T Pirttila; T Kivimaki; T Lehtimaki
Vascular fibrosis and calcification in the hippocampus in aging, Alzheimer disease, and Down syndrome.
Acta neuropathologica 2002;103(4):333-43.
2002: Zhao-Hui Wang; Y Ji; W Shan; B Zeng; N Raksadawan; Gregory M Pastores; Thomas Wisniewski; Edwin H Kolodny
Therapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease.
Neuroscience 2002;113(3):629-40.
2001: Burkhard Poeggeler; Leticia Miravalle; Michael G Zagorski; Thomas Wisniewski; Yau-Jan Chyan; Yanbin Zhang; H Shao; Tara Bryant-Thomas; Ruben Vidal; Blas Frangione; Jorge Ghiso; Miguel Pappolla
Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.
Biochemistry 2001;40(49):14995-5001.
2001: Pierre Aucouturier; Frederic Geissmann; Diane Damotte; G P Saborio; Harry C Meeker; Richard J Kascsak; R Kascsak; Richard I Carp; Thomas Wisniewski
Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie.
The Journal of clinical investigation 2001;108(5):703-8.
2001: Einar Sigurdsson; Henrieta Scholtzova; Pankaj D Mehta; Blas Frangione; Thomas Wisniewski
Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.
The American journal of pathology 2001;159(2):439-47.
2001: Jerzy Wegiel; Matthew Bobinski; M Tarnawski; J Dziewiatkowski; E Popovitch; DC Miller; Thomas Wisniewski; James Golomb; Mony J de Leon; Barry Reisberg
Fibrillar amyloid-beta affects neurofibrillary changes but only in neurons already involved in neurofibrillary degeneration.
Acta neuropathologica 2001;101(6):585-90.
2001: Jerzy Kulczycki; E Bertrand; W Łojkowska; Wieslaw K Dowjat; Thomas Wisniewski; M Łyczywek-Zwierz
[Familial Alzheimer's disease connected with mutation in presenilin gene 1 (P117L)].
Neurologia i neurochirurgia polska 2001;35(2):213-24.
2001: Thomas Wisniewski; Einar Sigurdsson; P Aucouturier; Blas Frangione
Conformation as therapeutic target in the prionoses and other neurodegenerative conditions.
Methods in molecular medicine 2001;59():223-36.
2001: Wieslaw K Dowjat; Henryk M Wisniewski; Thomas Wisniewski
Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments.
Neuroscience 2001;103(1):1-8.
2000: Adam A Golabek; Elizabeth Kida; Marius Walus; C Perez; Thomas Wisniewski; Claudio Soto
Sodium dodecyl sulfate-resistant complexes of Alzheimer's amyloid beta-peptide with the N-terminal, receptor binding domain of apolipoprotein E.
Biophysical journal 2000;79(2):1008-15.
2000: Pierre Aucouturier; Richard I Carp; Claude Carnaud; Thomas Wisniewski
Prion diseases and the immune system.
Clinical immunology (Orlando, Fla.) 2000;96(2):79-85.
2000: HJ Kayden; Thomas Wisniewski
On the biological activity of vitamin E.
The American journal of clinical nutrition 2000;72(1):201-3.
2000: S E Stoltzner; TJ Grenfell; Chica Mori; K E Wisniewski; Thomas Wisniewski; Dennis J Selkoe; Cynthia A Lemere
Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease.
The American journal of pathology 2000;156(2):489-99.
2000: Claudio Soto; R J Kascsak; GP Saborío; Pierre Aucouturier; Thomas Wisniewski; Frances Prelli; Richard J Kascsak; E Mendez; D A Harris; James Ironside; Fabrizio Tagliavini; Richard I Carp; Blas Frangione
Reversion of prion protein conformational changes by synthetic beta-sheet breaker peptides.
Lancet 2000;355(9199):192-7.
2000: Einar Sigurdsson; Bruno Permanne; Claudio Soto; Thomas Wisniewski; Blas Frangione
In vivo reversal of amyloid-beta lesions in rat brain.
Journal of neuropathology and experimental neurology 2000;59(1):11-7.
1999: Pierre Aucouturier; Richard J Kascsak; Blas Frangione; Thomas Wisniewski
Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt-Jakob disease.
Neuroscience letters 1999;274(1):33-6.
1999: Wieslaw K Dowjat; Thomas Wisniewski; Spiros Efthimiopoulos; Henryk M Wisniewski
Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations.
Neuroscience letters 1999;267(2):141-4.
1999: R P Copp; Thomas Wisniewski; Faycal Hentati; Abdelmajid Larnaout; Mongi Ben Hamida; HJ Kayden
Localization of alpha-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders.
Brain research 1999;822(1-2):80-7.
1999: P Aucouturier; Blas Frangione; Thomas Wisniewski
Prion diseases and the immune system.
Annales de médecine interne 1999;150(2):75-8.
1998: Spiros Efthimiopoulos; E Floor; Anastasios Georgakopoulos; Junichi Shioi; W Cui; Sukkid Yasothornsrikul; Vivian Y H Hook; Thomas Wisniewski; Luc BUEE; Nikolaos K Robakis
Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles.
Journal of neurochemistry 1998;71(6):2365-72.
1998: Nunzio Pomara; B Shao; Thomas Wisniewski; Pankaj D Mehta
Decreases in plasma A beta 1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 allele.
Neurochemical research 1998;23(12):1563-6.
1998: Thomas Wisniewski; Pierre Aucouturier; Claudio Soto; Blas Frangione
The prionoses and other conformational disorders.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1998;5(3):212-24.
1998: Jerzy Wegiel; Henryk M Wisniewski; Izabela Kuchna; M Tarnawski; E Badmajew; E Popovitch; Jerzy Kulczycki; Wieslaw K Dowjat; Thomas Wisniewski
Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L).
Journal of neuropathology and experimental neurology 1998;57(9):831-8.
1998: Valerie Askanas; W King Engel; CC Yang; RB Alvarez; Virginia M-Y Lee; Thomas Wisniewski
Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy.
The American journal of pathology 1998;152(4):889-95.
1998: Thomas Wisniewski; J E Goldman
Alpha B-crystallin is associated with intermediate filaments in astrocytoma cells.
Neurochemical research 1998;23(3):385-92.
1998: Thomas Wisniewski; Wieslaw K Dowjat; Joseph Buxbaum; OE Khorkova; Spiros Efthimiopoulos; Jerzy Kulczycki; Wanda Lojkowska; Jerzy Wegiel; Henryk M Wisniewski; Blas Frangione
A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years.
Neuroreport 1998;9(2):217-21.
1998: Krystyna E Wisniewski; Nanbert Zhong; Wojciech Kaczmarski; AL Kaczmarski; Elizabeth Kida; W Ted Brown; K O Schwarz; Alice Lazzarini; A J Rubin; Edward S Stenroos; William G Johnson; Thomas Wisniewski
Compound heterozygous genotype is associated with protracted juvenile neuronal ceroid lipofuscinosis.
Annals of neurology 1998;43(1):106-10.
1997: Bruno Permanne; C Perez; Claudio Soto; Blas Frangione; Thomas Wisniewski
Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.
Biochemical and biophysical research communications 1997;240(3):715-20.
1997: Thomas Wisniewski; Wieslaw K Dowjat; Bruno Permanne; J Palha; Asok Kumar; Gloria Gallo; Blas Frangione
Presenilin-1 is associated with Alzheimer's disease amyloid.
The American journal of pathology 1997;151(2):601-10.
1997: Jorge Ghiso; Miguel Calero; E Matsubara; S Governale; J Chuba; Ronald C Beavis; Thomas Wisniewski; Blas Frangione
Alzheimer's soluble amyloid beta is a normal component of human urine.
FEBS letters 1997;408(1):105-8.
1997: Thomas Wisniewski; Jorge Ghiso; Blas Frangione
Biology of A beta amyloid in Alzheimer's disease.
Neurobiology of disease 1997;4(5):313-28.
1996: M Lalowski; Adam A Golabek; Cynthia A Lemere; Dennis J Selkoe; Henryk M Wisniewski; Ronald C Beavis; Blas Frangione; Thomas Wisniewski
The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.
The Journal of biological chemistry 1996;271(52):33623-31.
1996: F Garzuly; Ruben Vidal; Thomas Wisniewski; F Brittig; Herbert Budka
Familial meningocerebrovascular amyloidosis, Hungarian type, with mutant transthyretin (TTR Asp18Gly)
Neurology 1996;47(6):1562-7.
1996: Ruben Vidal; Jorge Ghiso; Thomas Wisniewski; Blas Frangione
Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant.
FEBS letters 1996;393(1):19-23.
1996: Adam A Golabek; C Soto; T Vogel; Thomas Wisniewski
The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation.
The Journal of biological chemistry 1996;271(18):10602-6.
1996: M Baumann; Adam A Golabek; M Lalowski; Thomas Wisniewski
Micropreparative gel electrophoresis of low-molecular-weight peptides: purification of highly insoluble amyloid peptide fragments.
Analytical biochemistry 1996;236(2):191-8.
1996: C Soto; Adam A Golabek; Thomas Wisniewski; Eduardo M Castaño
Alzheimer's beta-amyloid peptide is conformationally modified by apolipoprotein E in vitro.
Neuroreport 1996;7(3):721-5.
1996: Joana Almeida Palha; Paula I Moreira; Thomas Wisniewski; Blas Frangione; Maria João Saraiva
Transthyretin gene in Alzheimer's disease patients.
Neuroscience letters 1996;204(3):212-4.
1996: M H Baumann; Thomas Wisniewski; Efrat Levy; G T Plant; Jorge Ghiso
C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type.
Biochemical and biophysical research communications 1996;219(1):238-42.
1996: Cynthia A Lemere; J K Blusztajn; Haruyasu Yamaguchi; Thomas Wisniewski; Takaomi C Saido; Dennis J Selkoe
Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.
Neurobiology of disease 1996;3(1):16-32.
1996: Ruben Vidal; F Garzuly; Herbert Budka; M Lalowski; R P Linke; F Brittig; Blas Frangione; Thomas Wisniewski
Meningocerebrovascular amyloidosis associated with a novel transthyretin mis-sense mutation at codon 18 (TTRD 18G)
The American journal of pathology 1996;148(2):361-6.
1996: Thomas Wisniewski; M Lalowski; M Baumann; Heikki Rauvala; Erkki Raulo; R Nolo; Blas Frangione
HB-GAM is a cytokine present in Alzheimer's and Down's syndrome lesions.
Neuroreport 1996;7(2):667-71.
1996: Thomas Wisniewski; M Lalowski; M Bobik; M Russell; J Strosznajder; Blas Frangione
Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs.
The Biochemical journal 1996;313 ( Pt 2)():575-80.
1996: Blas Frangione; Eduardo M Castaño; Thomas Wisniewski; Jorge Ghiso; F Prelli; Ruben Vidal
Apolipoprotein E and amyloidogenesis.
Ciba Foundation symposium 1996;199():132-41; discussion 141-5.
1996: Thomas Wisniewski; Blas Frangione
Molecular biology of brain aging and neurodegenerative disorders.
Acta neurobiologiae experimentalis 1996;56(1):267-79.
1995: Thomas Wisniewski; Joana Almeida Palha; Jorge Ghiso; Blas Frangione
S182 protein in Alzheimer's disease neuritic plaques.
Lancet 1995;346(8986):1366.
1995: Thomas Wisniewski; Blas Frangione
Amyloidosis in Alzheimer's disease.
Lancet 1995;346(8972):441.
1995: Thomas Wisniewski; Adam A Golabek; Elizabeth Kida; Krystyna E Wisniewski; Blas Frangione
Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis.
The American journal of pathology 1995;147(2):238-44.
1995: Adam A Golabek; M A Marques; M Lalowski; Thomas Wisniewski
Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid.
Neuroscience letters 1995;191(1-2):79-82.
1995: Thomas Wisniewski; M Lalowski; Adam A Golabek; T Vogel; Blas Frangione
Is Alzheimer's disease an apolipoprotein E amyloidosis?
Lancet 1995;345(8955):956-8.
1995: Jorge Ghiso; G T Plant; T Révész; Thomas Wisniewski; Blas Frangione
Familial cerebral amyloid angiopathy (British type) with nonneuritic amyloid plaque formation may be due to a novel amyloid protein.
Journal of the neurological sciences 1995;129(1):74-5.
1995: E M Castano; F Prelli; Thomas Wisniewski; Adam A Golabek; R A Kumar; C Soto; Blas Frangione
Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.
The Biochemical journal 1995;306 ( Pt 2)():599-604.
1995: Thomas Wisniewski; L Morelli; J Wegiel; Efrat Levy; Henryk M Wisniewski; Blas Frangione
The influence of apolipoprotein E isotypes on Alzheimer's disease pathology in 40 cases of Down's syndrome.
Annals of neurology 1995;37(1):136-8.
1995: Carlos A Mangone; Eduardo M Castaño; Efrat Levy; G Abiusi; Thomas Wisniewski; M R Marques; E Faccio; Philip B Gorelick; Blas Frangione; Roberto E P Sica
Early onset Alzheimer's disease in a South American pedigree from Argentina.
Acta neurologica Scandinavica 1995;91(1):6-13.
1994: Berislav V Zlokovic; C L Martel; Jasmina B Mackic; E Matsubara; Thomas Wisniewski; J Gordon McComb; Blas Frangione; Jorge Ghiso
Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta.
Biochemical and biophysical research communications 1994;205(2):1431-7.
1994: Thomas Wisniewski; Eduardo M Castaño; Adam A Golabek; T Vogel; Blas Frangione
Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.
The American journal of pathology 1994;145(5):1030-5.
1994: Gloria Gallo; Thomas Wisniewski; N H Choi-Miura; Jorge Ghiso; Blas Frangione
Potential role of apolipoprotein-E in fibrillogenesis.
The American journal of pathology 1994;145(3):526-30.
1994: David A Sanan; Karl H Weisgraber; S J Russell; Robert W Mahley; D Huang; Ann M Saunders; Donald E Schmechel; Thomas Wisniewski; Blas Frangione; Allen D Roses
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.
The Journal of clinical investigation 1994;94(2):860-9.
1994: Thomas Wisniewski; Jorge Ghiso; Blas Frangione
Alzheimer's disease and soluble A beta.
Neurobiology of aging 1994;15(2):143-52.
1994: Elizabeth Kida; Adam A Golabek; Thomas Wisniewski; Krystyna E Wisniewski
Regional differences in apolipoprotein E immunoreactivity in diffuse plaques in Alzheimer's disease brain.
Neuroscience letters 1994;167(1-2):73-6.
1994: Thomas Wisniewski; M Lalowski; Efrat Levy; M R Marques; Blas Frangione
The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient.
Annals of neurology 1994;35(2):245-6.
1994: Jorge Ghiso; Thomas Wisniewski; Blas Frangione
Unifying features of systemic and cerebral amyloidosis.
Molecular neurobiology 1994;8(1):49-64.
1994: Blas Frangione; Thomas Wisniewski; Jorge Ghiso
Chaperoning Alzheimer's amyloids.
Neurobiology of aging 1994;15 Suppl 2():S97-9.
1993: Thomas Wisniewski; E Castano; Jorge Ghiso; Blas Frangione
Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.
Annals of neurology 1993;34(4):631-3.
1993: Jorge Ghiso; E Matsubara; Alexei R Koudinov; N H Choi-Miura; M Tomita; Thomas Wisniewski; Blas Frangione
The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex.
The Biochemical journal 1993;293 ( Pt 1)():27-30.
1993: M M Rodrigues; S Rajagopalan; K Jones; V Nirankari; Thomas Wisniewski; Blas Frangione; P D Gorevic
Gelsolin immunoreactivity in corneal amyloid, wound healing, and macular and granular dystrophies.
American journal of ophthalmology 1993;115(5):644-52.
1993: Thomas Wisniewski; Adam A Golabek; E Matsubara; Jorge Ghiso; Blas Frangione
Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid.
Biochemical and biophysical research communications 1993;192(2):359-65.
1992: Jorge Ghiso; Thomas Wisniewski; Ruben Vidal; Agueda Rostagno; Blas Frangione
Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease.
The Biochemical journal 1992;282 ( Pt 2)():517-22.
1992: Thomas Wisniewski; Blas Frangione
Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid.
Neuroscience letters 1992;135(2):235-8.
1992: Toru Iwaki; Thomas Wisniewski; Akiko Iwaki; E Corbin; N Tomokane; Jun Tateishi; James E Goldman
Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions.
The American journal of pathology 1992;140(2):345-56.
1992: J Constantinidis; Krystyna E Wisniewski; Thomas Wisniewski
The adult and a new late adult forms of neuronal ceroid lipofuscinosis.
Acta neuropathologica 1992;83(5):461-8.
1992: Thomas Wisniewski; Blas Frangione
Molecular biology of Alzheimer's amyloid--Dutch variant.
Molecular neurobiology 1992;6(1):75-86.
1991: Thomas Wisniewski; Jorge Ghiso; Blas Frangione
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications 1991;180(3):1528.
1991: Eduardo M Castaño; Thomas Wisniewski; Blas Frangione
Inherited amyloids of the nervous system.
Current opinion in neurobiology 1991;1(3):448-54.
1991: Thomas Wisniewski; Jorge Ghiso; Blas Frangione
Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.
Biochemical and biophysical research communications 1991;179(3):1247-54.
1991: Matti Haltia; Jorge Ghiso; Thomas Wisniewski; S Kiuru; D Miller; Blas Frangione
Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies.
Neurobiology of aging 1991;12(4):313-6.
1991: Thomas Wisniewski; Matti Haltia; Jorge Ghiso; Blas Frangione
Lewy bodies are immunoreactive with antibodies raised to gelsolin related amyloid-Finnish type.
The American journal of pathology 1991;138(5):1077-83.
1991: J Constantinidis; Thomas Wisniewski
The dominant form of the pigmentary orthochromatic leukodystrophy.
Acta neuropathologica 1991;82(6):483-7.
1990: Thomas Wisniewski; Michael B Sisti; G Inhirami; Daniel M Knowles; J M Powers
Intracerebral solitary plasmacytoma.
Neurosurgery 1990;27(5):826-9; discussion 829.
1990: ST Onesti; Thomas Wisniewski; Kalmon D Post
Pituitary hemorrhage into a Rathke's cleft cyst.
Neurosurgery 1990;27(4):644-6.
1990: ST Onesti; Thomas Wisniewski; Kalmon D Post
Clinical versus subclinical pituitary apoplexy: presentation, surgical management, and outcome in 21 patients.
Neurosurgery 1990;26(6):980-6.
1990: T Kitaguchi; Krystyna E Wisniewski; S Maslinski; D Maslinska; Thomas Wisniewski; K S Kim
Beta-protein immunoreactivity in brains of patients with neuronal ceroid lipofuscinosis: ultrastructural and biochemical demonstration.
Neuroscience letters 1990;112(2-3):155-60.
1981: H M Moon; Thomas Wisniewski; P Merz; J De Martini; Henryk M Wisniewski
Partial purification of neurofilament subunits from bovine brains and studies on neurofilament assembly.
The Journal of cell biology 1981;89(3):560-7.