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Hui Zheng

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Chemicals & Drugs

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Alzheimer's Disease

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Publications

TOP 3
Qinxi Guo; Hui Zheng; Nicholas John Justice
Central CRF system perturbation in an Alzheimer's disease knockin mouse model.
Hong Lian; Robia G Pautler; Claudia S Robertson; Jennifer Rodriguez-Rivera; David J Shim; Brittany R Bitner; Samson S K Gaddam; Hui Zheng
IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery.
Mary Wiese; Adam Antebi; Hui Zheng
Regulation of neuronal APL-1 expression by cholesterol starvation.

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All Publications

2012: Qinxi Guo; Hui Zheng; Nicholas John Justice
Central CRF system perturbation in an Alzheimer's disease knockin mouse model.
Neurobiology of aging 2012;33(11):2678-91.
2012: Hong Lian; Robia G Pautler; Claudia S Robertson; Jennifer Rodriguez-Rivera; David J Shim; Brittany R Bitner; Samson S K Gaddam; Hui Zheng
IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery.
Molecular neurodegeneration 2012;7():47.
2012: Mary Wiese; Adam Antebi; Hui Zheng
Regulation of neuronal APL-1 expression by cholesterol starvation.
PloS one 2012;7(2):e32038.
2011: Baiping Wang; Wilbur Harrison; Paul A Overbeek; Hui Zheng
Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.
Development (Cambridge, England) 2011;138(20):4487-97.
2011: David J Shim; Li Yang; Paul J Chiao; Jeffrey L Noebels; J Graham Reed; Hui Zheng
Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons.
Molecular neurodegeneration 2011;6():42.
2011: Hui Zheng; Edward H Koo
Biology and pathophysiology of the amyloid precursor protein.
Molecular neurodegeneration 2011;6(1):27.
2010: Hongmei Li; Baiping Wang; Zilai Wang; Qinxi Guo; Katsuhiko Tabuchi; Robert E Hammer; Thomas C Südhof; Hui Zheng
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17362-7.
2010: Mary Wiese; Adam Antebi; Hui Zheng
Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans.
PloS one 2010;5(9):.
2009: Li Yang; Zilai Wang; Baiping Wang; Nicholas J Justice; Hui Zheng
Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(50):15660-8.
2009: Christopher C Shelton; Lei Zhu; Deming Chau; Li Yang; Rong Wang; Hakim Djaballah; Hui Zheng; Yueming Li
Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20228-33.
2009: Zilai Wang; Baiping Wang; Li Yang; Qinxi Guo; Nadia Aithmitti; Zhou Songyang; Hui Zheng
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(35):10788-801.
2009: Lisa Placanica; Leonid Tarassishin; Guangli Yang; Erica Peethumnongsin; Seong-Hun Kim; Hui Zheng; Sangram S Sisodia; Yueming Li
Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.
The Journal of biological chemistry 2009;284(5):2967-77.
2008: Verena Kallhoff-Munoz; Lingyun Hu; Xiaoli Chen; Robia Pautler; Hui Zheng
Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(44):11421-31.
2008: Feyza Engin; Zhenqiang Yao; Tao Yang; Guang Zhou; Terry Bertin; Ming Ming Jiang; Yuqing Chen; Lisa Wang; Hui Zheng; Richard E Sutton; Brendan F Boyce; Brendan Lee
Dimorphic effects of Notch signaling in bone homeostasis.
Nature medicine 2008;14(3):299-305.
2008: Tomohito Yagi; Cosmas Giallourakis; Subhasis Mohanty; Christina Scheidig; Jie Shen; Hui Zheng; Ramnik Xavier; Tomohito Yagi
Defective signal transduction in B lymphocytes lacking presenilin proteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(3):979-84.
2007: L Yang; B Wang; C Long; G Wu; Hui Zheng
Increased asynchronous release and aberrant calcium channel activation in amyloid precursor protein deficient neuromuscular synapses.
Neuroscience 2007;149(4):768-78.
2007: Baiping Wang; Li Yang; Zilai Wang; Hui Zheng
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14140-5.
2007: Karen Dell Brown Smith; Verena Kallhoff; Hui Zheng; Robia Pautler
In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease.
NeuroImage 2007;35(4):1401-8.
2007: Verena Kallhoff; Erica Peethumnongsin; Hui Zheng
Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease.
Molecular neurodegeneration 2007;2():6.
2006: Guangjin Pan; Jun Li; Yali Zhou; Hui Zheng; Duanqing Pei
A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(10):1730-2.
2006: Runsheng Wang; Baiping Wang; Wanxia He; Hui Zheng
Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology.
The Journal of biological chemistry 2006;281(22):15330-6.
2006: Yu Deng; Leonid Tarassishin; Verena Kallhoff; Erica Peethumnongsin; Ling Wu; Yueming Li; Hui Zheng
Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(14):3845-54.
2006: Dongming Cai; Minghao Zhong; Runsheng Wang; William Netzer; Dennis Shields; Hui Zheng; Sangram S Sisodia; David A Foster; Fred S Gorelick; Huaxi Xu; Paul Greengard
Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1936-40.
2006: Runsheng Wang; Phuong Tang; Pei Wang; Raymond E Boissy; Hui Zheng
Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(2):353-8.
2006: Hui Zheng; Edward H Koo
The amyloid precursor protein: beyond amyloid.
Molecular neurodegeneration 2006;1():5.
2005: Ping Han; Fei Dou; Feng Li; Xue Zhang; Yun-Wu Zhang; Hui Zheng; Stuart A Lipton; Huaxi Xu; Francesca-Fang Liao
Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(50):11542-52.
2005: Guang Yang; Yan-Dao Gong; Kai Gong; Wu-Ling Jiang; Elaine Kwon; Pei Wang; Hui Zheng; Xiu-Fang Zhang; Wen-Biao Gan; Nan-Ming Zhao
Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2.
Neuroscience letters 2005;384(1-2):66-71.
2005: Pei Wang; Guang Yang; Dennis R Mosier; Paul Chang; Tahire Zaidi; Yan-Dao Gong; Nan-Ming Zhao; Bertha Dominguez; Kuo-Fen Lee; Wen-Biao Gan; Hui Zheng
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(5):1219-25.
2004: Cary Esselens; Viola Oorschot; Veerle Baert; Tim Raemaekers; Kurt Spittaels; Lutgarde Serneels; Hui Zheng; Paul Saftig; Bart De Strooper; Judith Klumperman; Willem ANNAERT
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
The Journal of cell biology 2004;166(7):1041-54.
2004: Yibing Qyang; Stuart M Chambers; Pei Wang; Xuefeng Xia; Xiaoli Chen; Margaret A Goodell; Hui Zheng
Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage.
Biochemistry 2004;43(18):5352-9.
2004: Yuxiang Sun; Pei Wang; Hui Zheng; Roy G Smith
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4679-84.
2004: Runsheng Wang; Kelly T Dineley; J David Sweatt; Hui Zheng
Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis.
Neuroscience 2004;126(2):305-12.
2003: Pei Wang; Fred A Pereira; Duane Beasley; Hui Zheng
Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis.
Development (Cambridge, England) 2003;130(20):5019-29.
2003: Dongming Cai; Jae Yoon Leem; Jeffrey P Greenfield; Pei Wang; Benny S Kim; Runsheng Wang; Kryslaine O Lopes; Seong-Hun Kim; Hui Zheng; Paul Greengard; Sangram S Sisodia; Gopal Thinakaran; Huaxi Xu
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
The Journal of biological chemistry 2003;278(5):3446-54.
2002: Christina A Wilson; Robert W Doms; Hui Zheng; Virginia M-Y Lee
Presenilins are not required for A beta 42 production in the early secretory pathway.
Nature neuroscience 2002;5(9):849-55.
2002: Xuefeng Xia; Pei Wang; Xiaoyan Sun; Salvador Soriano; Wan-Kyng Shum; Haruyasu Yamaguchi; Myrna E Trumbauer; Akihiko Takashima; Edward H Koo; Hui Zheng
The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8760-5.
2002: Kelly T Dineley; Xuefeng Xia; Duy Bui; J David Sweatt; Hui Zheng
Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.
The Journal of biological chemistry 2002;277(25):22768-80.
2002: Tobias Moehlmann; Edith Winkler; Xuefeng Xia; Dieter Edbauer; Jill Murrell; Anja Capell; Christoph Kaether; Hui Zheng; Bernardino Ghetti; Christian Haass; Harald Steiner
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8025-30.
2002: Robin A Morton; Frederick M Kuenzi; Stephen Fitzjohn; Thomas W Rosahl; David Smith; Hui Zheng; Mark S Shearman; Graham Collingridge; Guy R Seabrook
Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1.
Neuroscience letters 2002;319(1):37-40.
2002: Hui Zheng; H Xu; S N Uljon; R Gross; K Hardy; J Gaynor; John LaFrancois; J Simpkins; Lorenzo M Refolo; Suzana Petanceska; Runsheng Wang; karen duff
Modulation of A(beta) peptides by estrogen in mouse models.
Journal of neurochemistry 2002;80(1):191-6.
2001: Xuefeng Xia; S Qian; Salvador Soriano; Yuejin Wu; A M Fletcher; Xiao-Jing Wang; Edward H Koo; X Wu; Hui Zheng
Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10863-8.
2001: Robert A Cherny; Craig S Atwood; Michel E Xilinas; D N Gray; Walton D Jones; Catriona A McLean; Kevin J Barnham; Irene Volitakis; Fiona Fraser; Y Kim; Xudong Huang; Lee E Goldstein; Robert D. Moir; JT Lim; Konrad Beyreuther; Hui Zheng; Rudolph E Tanzi; Colin L Masters; Ashley I Bush
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Neuron 2001;30(3):665-76.
2000: Cécile Viollet; Cyrille Vaillend; Catherine Videau; Marie-Thérèse Bluet-Pajot; A Ungerer; A L'Héritier; C Kopp; Brigitte Potier; Jean-Marie Billard; J Schaeffer; R G Smith; Susan P Rohrer; H Wilkinson; Hui Zheng; Jacques Epelbaum
Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice.
The European journal of neuroscience 2000;12(10):3761-70.
1999: Anthony R White; Gerd Multhaup; Fran Maher; Shayne A Bellingham; James Camakaris; Hui Zheng; Ashley I Bush; Konrad Beyreuther; Colin L Masters; Roberto Cappai
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(21):9170-9.
1999: Anthony R White; R Reyes; Julian F B Mercer; James Camakaris; Hui Zheng; Ashley I Bush; Gerd Multhaup; Konrad Beyreuther; Colin L Masters; Roberto Cappai
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice.
Brain research 1999;842(2):439-44.
1999: François G Gervais; D Xu; George S Robertson; John P Vaillancourt; Y Zhu; J Huang; A LeBlanc; D Smith; M Rigby; Mark S Shearman; E E Clarke; Hui Zheng; L H Van Der Ploeg; Salvatore C Ruffolo; Nancy A Thornberry; Steven Xanthoudakis; Robert Zamboni; Sophie Roy; Donald W Nicholson
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
Cell 1999;97(3):395-406.
1999: Gerard R Dawson; Guy R Seabrook; Hui Zheng; D W Smith; S Graham; G O'Dowd; BJ Bowery; Susan Boyce; Myrna E Trumbauer; H Y Chen; Lex H T Van Der Ploeg; DJ Sirinathsinghji
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein.
Neuroscience 1999;90(1):1-13.
1999: Guy R Seabrook; D W Smith; BJ Bowery; A Easter; T Reynolds; Stephen Fitzjohn; Robin A Morton; Hui Zheng; Gerard R Dawson; DJ Sirinathsinghji; Ceri H Davies; Graham Collingridge; Raymond G Hill
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein.
Neuropharmacology 1999;38(3):349-59.
1999: Amie L Phinney; Michael E Calhoun; D P Wolfer; H P Lipp; Hui Zheng; Mathias Jucker
No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice.
Neuroscience 1999;90(4):1207-16.
1998: Sarah J Harper; James Bilsland; M S Shearman; Hui Zheng; Lex H T Van Der Ploeg; DJ Sirinathsinghji
Mouse cortical neurones lacking APP show normal neurite outgrowth and survival responses in vitro.
Neuroreport 1998;9(13):3053-8.
1998: Anthony R White; Hui Zheng; Denise Galatis; Fran Maher; L Hesse; Gerd Multhaup; Konrad Beyreuther; Colin L Masters; Roberto Cappai
Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(16):6207-17.
1998: S Qian; P Jiang; Xiao-Ming Guan; G Singh; Myrna E Trumbauer; H Yu; H Y Chen; L H Van de Ploeg; Hui Zheng
Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.
Neuron 1998;20(3):611-7.
1997: Ruth G Perez; Hui Zheng; L H Van der Ploeg; Edward H Koo
The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(24):9407-14.
1997: C S von Koch; Hui Zheng; H Chen; Myrna E Trumbauer; Gopal Thinakaran; Lex H T Van Der Ploeg; Donald L Price; Sangram S Sisodia
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice.
Neurobiology of aging 1997;18(6):661-9.
1997: Hui Zheng; A Bailey; M H Jiang; K Honda; H Y Chen; Myrna E Trumbauer; Lex H T Van Der Ploeg; James M Schaeffer; G Leng; Roy G Smith
Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons.
Molecular endocrinology (Baltimore, Md.) 1997;11(11):1709-17.
1997: Philip C Wong; Hui Zheng; Honglin Chen; Mark W Becher; DJ Sirinathsinghji; Myrna E Trumbauer; H Y Chen; Donald L Price; Lex H T Van Der Ploeg; Sangram S Sisodia
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm.
Nature 1997;387(6630):288-92.
1996: Hui Zheng; M Jiang; M E Trumbauer; R Hopkins; DJ Sirinathsinghji; K A Stevens; M W Conner; H H Slunt; Sangram S Sisodia; H Y Chen; Lex H T Van Der Ploeg
Mice deficient for the amyloid precursor protein gene.
Annals of the New York Academy of Sciences 1996;777():421-6.
1995: Hui Zheng; M Jiang; M E Trumbauer; DJ Sirinathsinghji; R Hopkins; D W Smith; R P Heavens; Gerard R Dawson; Susan Boyce; M W Conner; K A Stevens; H H Slunt; S S Sisoda; H Y Chen; Lex H T Van Der Ploeg
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.
Cell 1995;81(4):525-31.