William R. Jacobs Jr.

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Banaei Niaz; Kincaid Eleanor Z; Lin S-Y Grace; Desmond Edward; Jacobs William R; Ernst Joel D
Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green.
Venkataswamy Manjunatha M; Baena Andres; Goldberg Michael F; Bricard Gabriel; Im Jin S; Chan John; Reddington Faye; Besra Gurdyal S; Jacobs William R; Porcelli Steven A
Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin.
Capinos Scherer Charles F; Endsley Janice J; de Aguiar Juliana B; Jacobs William R; Larsen Michelle H; Palmer Mitchell V; Nonnecke Brian J; Ray Waters W; Mark Estes D
Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovisDeltaRD1.

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All Publications

2009: Banaei Niaz; Kincaid Eleanor Z; Lin S-Y Grace; Desmond Edward; Jacobs William R; Ernst Joel D
Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green.
Antimicrobial agents and chemotherapy 2009;53(9):3799-802.
2009: Venkataswamy Manjunatha M; Baena Andres; Goldberg Michael F; Bricard Gabriel; Im Jin S; Chan John; Reddington Faye; Besra Gurdyal S; Jacobs William R; Porcelli Steven A
Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1644-56.
2009: Capinos Scherer Charles F; Endsley Janice J; de Aguiar Juliana B; Jacobs William R; Larsen Michelle H; Palmer Mitchell V; Nonnecke Brian J; Ray Waters W; Mark Estes D
Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovisDeltaRD1.
Transboundary and emerging diseases 2009;56(6-7):228-39.
2009: Larsen Michelle H; Biermann Karolin; Chen Bing; Hsu Tsungda; Sambandamurthy Vasan K; Lackner Andrew A; Aye Pyone Pyone; Didier Peter; Huang Dan; Shao Linyun; Wei Huiyong; Letvin Norman L; Frothingham Richard; Haynes Barton F; Chen Zheng W; Jacobs William R
Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates.
Vaccine 2009;27(34):4709-17.
2009: Parra Marcela; Yang Amy L; Lim JaeHyun; Kolibab Kristopher; Derrick Steven; Cadieux Nathalie; Perera Liyanage P; Jacobs William R; Brennan Michael; Morris Sheldon L
Development of a murine mycobacterial growth inhibition assay for evaluating vaccines against Mycobacterium tuberculosis.
Clinical and vaccine immunology : CVI 2009;16(7):1025-32.
2009: Cirillo Suat L G; Subbian Selvakumar; Chen Bing; Weisbrod Torin R; Jacobs William R; Cirillo Jeffrey D
Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination.
Infection and immunity 2009;77(6):2557-67.
2009: Gopalaswamy Radha; Narayanan Sujatha; Chen Bing; Jacobs William R; Av-Gay Yossef
The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection.
FEMS microbiology letters 2009;295(1):23-9.
2009: Cayabyab Mark J; Korioth-Schmitz Birgit; Sun Yue; Carville Angela; Balachandran Harikrishnan; Miura Ayako; Carlson Kevin R; Buzby Adam P; Haynes Barton F; Jacobs William R; Letvin Norman L
Recombinant Mycobacterium bovis BCG prime-recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus-specific T-cell responses.
Journal of virology 2009;83(11):5505-13.
2009: Chen Crystal Y; Huang Dan; Wang Richard C; Shen Ling; Zeng Gucheng; Yao Shuyun; Shen Yun; Halliday Lisa; Fortman Jeff; McAllister Milton; Estep Jim; Hunt Robert; Vasconcelos Daphne; Du George; Porcelli Steven A; Larsen Michelle H; Jacobs William R; Haynes Barton F; Letvin Norman L; Chen Zheng W
A critical role for CD8 T cells in a nonhuman primate model of tuberculosis.
PLoS pathogens 2009;5(4):e1000392.
2009: Yam Katherine C; D'Angelo Igor; Kalscheuer Rainer; Zhu Haizhong; Wang Jian-Xin; Snieckus Victor; Ly Lan H; Converse Paul J; Jacobs William R; Strynadka Natalie; Eltis Lindsay D
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
PLoS pathogens 2009;5(3):e1000344.
2009: Colangeli R; Haq A; Arcus V L; Summers E; Magliozzo R S; McBride A; Mitra A K; Radjainia M; Khajo A; Jacobs W R; Salgame P; Alland D
The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4414-8.
2009: Zimmerman Dawn M; Waters W Ray; Lyashchenko Konstantin P; Nonnecke Brian J; Armstrong Douglas L; Jacobs William R; Larsen Michelle H; Egan Erin; Dean Gregg A
Safety and immunogenicity of the Mycobacterium tuberculosis DeltalysA DeltapanCD vaccine in domestic cats infected with feline immunodeficiency virus.
Clinical and vaccine immunology : CVI 2009;16(3):427-9.
2009: Endsley Janice J; Waters W Ray; Palmer Mitchell V; Nonnecke Brian J; Thacker Tyler C; Jacobs William R; Larsen Michelle H; Hogg Alison; Shell Elisabeth; McAlauy Martin; Scherer Charles F Capinosh; Coffey Tracey; Howard Chris J; Villareal-Ramos Bernardo; Estes D Mark
The calf model of immunity for development of a vaccine against tuberculosis.
Veterinary immunology and immunopathology 2009;128(1-3):199-204.
2009: Waters W Ray; Palmer Mitchell V; Nonnecke Brian J; Thacker Tyler C; Scherer Charles F Capinos; Estes D Mark; Hewinson R Glyn; Vordermeier H Martin; Barnes S Whitney; Federe Glenn C; Walker John R; Glynne Richard J; Hsu Tsungda; Weinrick Brian; Biermann Karolin; Larsen Michelle H; Jacobs William R
Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves.
Vaccine 2009;27(8):1201-9.
2009: Freundlich Joel S; Wang Feng; Vilchèze Catherine; Gulten Gulcin; Langley Robert; Schiehser Guy A; Jacobus David P; Jacobs William R; Sacchettini James C
Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis.
ChemMedChem 2009;4(2):241-8.
2009: Lee Warren L; Gold Benjamin; Darby Crystal; Brot Nathan; Jiang Xiuju; de Carvalho Luiz Pedro S; Wellner Daniel; St John Gregory; Jacobs William R; Nathan Carl
Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite.
Molecular microbiology 2009;71(3):583-93.
2009: Lim JaeHyun; Derrick Steven C; Kolibab Kristopher; Yang Amy Li; Porcelli Steven; Jacobs William R; Morris Sheldon L
Early pulmonary cytokine and chemokine responses in mice immunized with three different vaccines against Mycobacterium tuberculosis determined by PCR array.
Clinical and vaccine immunology : CVI 2009;16(1):122-6.
2009: Gratraud Paul; Huws Enlli; Falkard Brie; Adjalley Sophie; Fidock David A; Berry Laurence; Jacobs William R; Baird Mark S; Vial Henri; Kremer Laurent
Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.
PloS one 2009;4(9):e6889.
2009: Waters W Ray; Palmer Mitchell V; Nonnecke Brian J; Thacker Tyler C; Estes D Mark; Larsen Michelle H; Jacobs William R; Andersen Peter; McNair James; Minion F C; Lyashchenko Konstantin P; Hewinson R Glyn; Vordermeier H Martin; Sacco Randy E
Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria.
PloS one 2009;4(7):e6414.
2009: Piuri Mariana; Jacobs William R; Hatfull Graham F
Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis.
PloS one 2009;4(3):e4870.
2008: Bueno Susan M; González Pablo A; Cautivo Kelly M; Mora Jorge E; Leiva Eduardo D; Tobar Hugo E; Fennelly Glenn J; Eugenin Eliseo A; Jacobs William R; Riedel Claudia A; Kalergis Alexis M
Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(52):20822-7.
2008: Yu Min; Kumar T R Santha; Nkrumah Louis J; Coppi Alida; Retzlaff Silke; Li Celeste D; Kelly Brendan J; Moura Pedro A; Lakshmanan Viswanathan; Freundlich Joel S; Valderramos Juan-Carlos; Vilcheze Catherine; Siedner Mark; Tsai Jennifer H-C; Falkard Brie; Sidhu Amar Bir Singh; Purcell Lisa A; Gratraud Paul; Kremer Laurent; Waters Andrew P; Schiehser Guy; Jacobus David P; Janse Chris J; Ager Arba; Jacobs William R; Sacchettini James C; Heussler Volker; Sinnis Photini; Fidock David A
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Cell host & microbe 2008;4(6):567-78.
2008: Qiu Liyou; Huang Dan; Chen Cystal Y; Wang Richard; Shen Ling; Shen Yun; Hunt Robert; Estep James; Haynes Barton F; Jacobs William R; Letvin Norman; Du George; Chen Zheng W
Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses.
The Journal of infectious diseases 2008;198(10):1514-9.
2008: Kumar Vanaja; Loganathan Prabakaran; Sivaramakrishnan Gomathi; Kriakov Jordan; Dusthakeer Azger; Subramanyam Balaji; Chan John; Jacobs William R; Paranji Rama Narayanan
Characterization of temperate phage Che12 and construction of a new tool for diagnosis of tuberculosis.
Tuberculosis (Edinburgh, Scotland) 2008;88(6):616-23.
2008: Porcelli Steven A; Jacobs William R
Tuberculosis: unsealing the apoptotic envelope.
Nature immunology 2008;9(10):1101-2.
2008: Vilchèze Catherine; Av-Gay Yossef; Attarian Rodgoun; Liu Zhen; Hazbón Manzour H; Colangeli Roberto; Chen Bing; Liu Weijun; Alland David; Sacchettini James C; Jacobs William R
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.
Molecular microbiology 2008;69(5):1316-29.
2008: Arai Masayoshi; Sobou Mari; Vilchéze Catherine; Baughn Anthony; Hashizume Hiroyuki; Pruksakorn Patamaporn; Ishida Shunsuke; Matsumoto Makoto; Jacobs William R; Kobayashi Motomasa
Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent.
Bioorganic & medicinal chemistry 2008;16(14):6732-6.
2008: Ojha Anil K; Baughn Anthony D; Sambandan Dhinakaran; Hsu Tsungda; Trivelli Xavier; Guerardel Yann; Alahari Anuradha; Kremer Laurent; Jacobs William R; Hatfull Graham F
Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
Molecular microbiology 2008;69(1):164-74.
2008: Dao Dee N; Sweeney Kari; Hsu Tsungda; Gurcha Sudagar S; Nascimento Ivan P; Roshevsky Dan; Besra Gurdyal S; Chan John; Porcelli Steven A; Jacobs William R
Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.
PLoS pathogens 2008;4(6):e1000081.
2008: Mohamedmohaideen Nilofar N; Palaninathan Satheesh K; Morin Paul M; Williams Brad J; Braunstein Miriam; Tichy Shane E; Locker Joseph; Russell David H; Jacobs William R; Sacchettini James C
Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis.
Biochemistry 2008;47(23):6092-102.
2008: Mishra Arun K; Alderwick Luke J; Rittmann Doris; Wang Cindy; Bhatt Apoorva; Jacobs William R; Takayama Kuni; Eggeling Lothar; Besra Gurdyal S
Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.
Molecular microbiology 2008;68(6):1595-613.
2008: Im Jin S; Kang Tae-Jin; Lee Seong-Beom; Kim Chi-Hong; Lee Sang-Haak; Venkataswamy Manjunatha M; Serfass Evan R; Chen Bing; Illarionov Petr A; Besra Gurdyal S; Jacobs William R; Chae Gue-Tae; Porcelli Steven A
Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections.
Clinical immunology (Orlando, Fla.) 2008;127(2):214-24.
2008: Jayakumar Deepak; Jacobs William R; Narayanan Sujatha
Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection.
Cellular microbiology 2008;10(2):365-74.
2008: Reddy Manchi C M; Gokulan Kuppan; Jacobs William R; Ioerger Thomas R; Sacchettini James C
Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response.
Protein science : a publication of the Protein Society 2008;17(1):159-70.
2008: Gopalaswamy Radha; Narayanan Sujatha; Jacobs William R; Av-Gay Yossef
Mycobacterium smegmatis biofilm formation and sliding motility are affected by the serine/threonine protein kinase PknF.
FEMS microbiology letters 2008;278(1):121-7.
2008: Banaiee Niaz; January Vanessa; Barthus Charmaine; Lambrick Maureen; Roditi Denise; Behr Marcel A; Jacobs William R; Steyn Lafras M
Evaluation of a semi-automated reporter phage assay for susceptibility testing of Mycobacterium tuberculosis isolates in South Africa.
Tuberculosis (Edinburgh, Scotland) 2008;88(1):64-8.
2008: Huang Dan; Shen Yun; Qiu Liyou; Chen Crystal Y; Shen Ling; Estep Jim; Hunt Robert; Vasconcelos Daphne; Du George; Aye Pyone; Lackner Andrew A; Larsen Michelle H; Jacobs William R; Haynes Barton F; Letvin Norman L; Chen Zheng W
Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection.
Infection and immunity 2008;76(1):426-36.
2007: Waters W Ray; Palmer Mitchell V; Nonnecke Brian J; Thacker Tyler C; Scherer Charles F Capinos; Estes D Mark; Jacobs William R; Glatman-Freedman Aharona; Larsen Michelle H
Failure of a Mycobacterium tuberculosis DeltaRD1 DeltapanCD double deletion mutant in a neonatal calf aerosol M. bovis challenge model: comparisons to responses elicited by M. bovis bacille Calmette Guerin.
Vaccine 2007;25(45):7832-40.
2007: Al-Sayyed Ban; Piperdi Sajida; Yuan Xinni; Li Anping; Besra Gurdyal S; Jacobs William R; Casadevall Arturo; Glatman-Freedman Aharona
Monoclonal antibodies to Mycobacterium tuberculosis CDC 1551 reveal subcellular localization of MPT51.
Tuberculosis (Edinburgh, Scotland) 2007;87(6):489-97.
2007: Mo Yongkai; Quanquin Natalie M; Vecino William H; Ranganathan Uma Devi; Tesfa Lydia; Bourn William; Derbyshire Keith M; Letvin Norman L; Jacobs William R; Fennelly Glenn J
Genetic alteration of Mycobacterium smegmatis to improve mycobacterium-mediated transfer of plasmid DNA into mammalian cells and DNA immunization.
Infection and immunity 2007;75(10):4804-16.
2007: Pinto Rachel; Harrison Joseph S; Hsu Tsungda; Jacobs William R; Leyh Thomas S
Sulfite reduction in mycobacteria.
Journal of bacteriology 2007;189(18):6714-22.
2007: Larsen Michelle H; Biermann Karolin; Jacobs William R
Analyses of Mycobacterium tuberculosis proteins.
Current protocols in microbiology 2007;Chapter 10():Unit 10A.4.
2007: Larsen Michelle H; Biermann Karolin; Tandberg Steven; Hsu Tsugunda; Jacobs William R
Genetic Manipulation of Mycobacterium tuberculosis.
Current protocols in microbiology 2007;Chapter 10():Unit 10A.2.
2007: Larsen Michelle H; Biermann Karolin; Jacobs William R
Laboratory maintenance of Mycobacterium tuberculosis.
Current protocols in microbiology 2007;Chapter 10():Unit 10A.1.
2007: Hinchey Joseph; Lee Sunhee; Jeon Bo Y; Basaraba Randall J; Venkataswamy Manjunatha M; Chen Bing; Chan John; Braunstein Miriam; Orme Ian M; Derrick Steven C; Morris Sheldon L; Jacobs William R; Porcelli Steven A
Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis.
The Journal of clinical investigation 2007;117(8):2279-88.
2007: Banaiee Niaz; Jacobs William R; Ernst Joel D
LspA-independent action of globomycin on Mycobacterium tuberculosis.
The Journal of antimicrobial chemotherapy 2007;60(2):414-6.
2007: Freundlich Joel S; Wang Feng; Tsai Han-Chun; Kuo Mack; Shieh Hong-Ming; Anderson John W; Nkrumah Louis J; Valderramos Juan-Carlos; Yu Min; Kumar T R Santha; Valderramos Stephanie G; Jacobs William R; Schiehser Guy A; Jacobus David P; Fidock David A; Sacchettini James C
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.
The Journal of biological chemistry 2007;282(35):25436-44.
2007: Glover Robert T; Kriakov Jordan; Garforth Scott J; Baughn Anthony D; Jacobs William R
The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
Journal of bacteriology 2007;189(15):5495-503.
2007: Velmurugan Kamalakannan; Chen Bing; Miller Jessica L; Azogue Sharon; Gurses Serdar; Hsu Tsungda; Glickman Michael; Jacobs William R; Porcelli Steven A; Briken Volker
Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells.
PLoS pathogens 2007;3(7):e110.
2007: Yu Jae-Sung; Peacock James W; Jacobs William R; Frothingham Richard; Letvin Norman L; Liao Hua-Xin; Haynes Barton F
Recombinant Mycobacterium bovis bacillus Calmette-Guerin elicits human immunodeficiency virus type 1 envelope-specific T lymphocytes at mucosal sites.
Clinical and vaccine immunology : CVI 2007;14(7):886-93.
2007: Ngo Silvana C; Zimhony Oren; Chung Woo Jin; Sayahi Halimah; Jacobs William R; Welch John T
Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.
Antimicrobial agents and chemotherapy 2007;51(7):2430-5.
2007: Vilchèze Catherine; Jacobs William R
Isolation and analysis of Mycobacterium tuberculosis mycolic acids.
Current protocols in microbiology 2007;Chapter 10():Unit 10A.3.
2007: Murillo A C; Li H Y; Alber T; Baker E N; Berger J M; Cherney L T; Cherney M M; Cho Yoon Song; Eisenberg D; Garen C R; Goulding C W; Hung L W; Ioerger T R; Jacobs W R; James M N G; Kim C; Krieger I; Lott J S; Sankaranarayanan R; Segelke B W; Terwilliger T C; Wang F; Wang S; Sacchettini J C
High throughput crystallography of TB drug targets.
Infectious disorders drug targets 2007;7(2):127-39.
2007: Colangeli Roberto; Helb Danica; Vilchèze Catherine; Hazbón Manzour Hernando; Lee Chee-Gun; Safi Hassan; Sayers Brendan; Sardone Irene; Jones Marcus B; Fleischmann Robert D; Peterson Scott N; Jacobs William R; Alland David
Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis.
PLoS pathogens 2007;3(6):e87.
2007: Bhatt Apoorva; Molle Virginie; Besra Gurdyal S; Jacobs William R; Kremer Laurent
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development.
Molecular microbiology 2007;64(6):1442-54.
2007: Bhatt Apoorva; Fujiwara Nagatoshi; Bhatt Kiranmai; Gurcha Sudagar S; Kremer Laurent; Chen Bing; Chan John; Porcelli Steven A; Kobayashi Kazuo; Besra Gurdyal S; Jacobs William R
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5157-62.
2007: Bhatt Kiranmai; Gurcha Sudagar S; Bhatt Apoorva; Besra Gurdyal S; Jacobs William R
Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
Microbiology (Reading, England) 2007;153(Pt 2):513-20.
2007: Zimhony Oren; Vilchèze Catherine; Arai Masayoshi; Welch John T; Jacobs William R
Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.
Antimicrobial agents and chemotherapy 2007;51(2):752-4.
2007: Derrick Steven C; Evering Teresa H; Sambandamurthy Vasan K; Jalapathy Kripa V; Hsu Tsungda; Chen Bing; Chen Mei; Russell Robert G; Junqueira-Kipnis Ana Paula; Orme Ian M; Porcelli Steven A; Jacobs William R; Morris Sheldon L
Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine.
Immunology 2007;120(2):192-206.
2007: Wang Feng; Langley Robert; Gulten Gulcin; Dover Lynn G; Besra Gurdyal S; Jacobs William R; Sacchettini James C
Mechanism of thioamide drug action against tuberculosis and leprosy.
The Journal of experimental medicine 2007;204(1):73-8.
2007: Hovav Avi-Hai; Cayabyab Mark J; Panas Michael W; Santra Sampa; Greenland John; Geiben Ralf; Haynes Barton F; Jacobs William R; Letvin Norman L
Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis.
Journal of virology 2007;81(1):74-83.
2007: Vilchèze Catherine; Jacobs William R
The mechanism of isoniazid killing: clarity through the scope of genetics.
Annual review of microbiology 2007;61():35-50.
2006: Lee Sunhee; Jeon Bo-Young; Bardarov Svetoslav; Chen Mei; Morris Sheldon L; Jacobs William R
Protection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine model.
Infection and immunity 2006;74(11):6491-5.
2006: Yu Jae-Sung; Peacock James W; Vanleeuwen Stacie; Hsu Tsungda; Jacobs William R; Cayabyab Mark J; Letvin Norman L; Frothingham Richard; Staats Herman F; Liao Hua-Xin; Haynes Barton F
Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis.
Clinical and vaccine immunology : CVI 2006;13(11):1204-11.
2006: Banaiee N; Jacobs W R; Ernst J D
Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages.
Infection and immunity 2006;74(11):6449-57.
2006: Junqueira-Kipnis Ana Paula; Basaraba Randall J; Gruppo Veronica; Palanisamy Gopinath; Turner Oliver C; Hsu Tsungda; Jacobs William R; Fulton Scott A; Reba Scott M; Boom W Henry; Orme Ian M
Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma.
Immunology 2006;119(2):224-31.
2006: Vilchèze Catherine; Wang Feng; Arai Masayoshi; Hazbón Manzour Hernando; Colangeli Roberto; Kremer Laurent; Weisbrod Torin R; Alland David; Sacchettini James C; Jacobs William R
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.
Nature medicine 2006;12(9):1027-9.
2006: Pérez Jacqueline; Garcia Rósula; Bach Horacio; de Waard Jacobus H; Jacobs William R; Av-Gay Yossef; Bubis Jose; Takiff Howard E
Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD.
Biochemical and biophysical research communications 2006;348(1):6-12.
2006: Sambandamurthy Vasan K; Derrick Steven C; Hsu Tsungda; Chen Bing; Larsen Michelle H; Jalapathy Kripa V; Chen Mei; Kim John; Porcelli Steven A; Chan John; Morris Sheldon L; Jacobs William R
Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis.
Vaccine 2006;24(37-39):6309-20.
2006: Nkrumah Louis J; Muhle Rebecca A; Moura Pedro A; Ghosh Pallavi; Hatfull Graham F; Jacobs William R; Fidock David A
Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase.
Nature methods 2006;3(8):615-21.
2006: Hatfull Graham F; Pedulla Marisa L; Jacobs-Sera Deborah; Cichon Pauline M; Foley Amy; Ford Michael E; Gonda Rebecca M; Houtz Jennifer M; Hryckowian Andrew J; Kelchner Vanessa A; Namburi Swathi; Pajcini Kostandin V; Popovich Mark G; Schleicher Donald T; Simanek Brian Z; Smith Alexis L; Zdanowicz Gina M; Kumar Vanaja; Peebles Craig L; Jacobs William R; Lawrence Jeffrey G; Hendrix Roger W
Exploring the mycobacteriophage metaproteome: phage genomics as an educational platform.
PLoS genetics 2006;2(6):e92.
2006: Rao Vivek; Gao Feng; Chen Bing; Jacobs William R; Glickman Michael S
Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence.
The Journal of clinical investigation 2006;116(6):1660-7.
2006: Aravindhan Vivekanandhan; Narayanan Sujatha; Gautham Namasivayam; Prasad Vinayaka; Kannan P; Jacobs William R; Narayanan Paranjir
T-h-2 immunity and CD3+CD45RBlow-activated T cells in mice immunized with recombinant bacillus Calmette-Guérin expressing HIV-1 principal neutralizing determinant epitope.
FEMS immunology and medical microbiology 2006;47(1):45-55.
2006: Tufariello JoAnn M; Mi Kaixia; Xu Jiayong; Manabe Yukari C; Kesavan Anup K; Drumm Joshua; Tanaka Kathryn; Jacobs William R; Chan John
Deletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosis.
Infection and immunity 2006;74(5):2985-95.
2006: Freundlich Joel S; Yu Min; Lucumi Edinson; Kuo Mack; Tsai Han-Chun; Valderramos Juan-Carlos; Karagyozov Luchezar; Jacobs William R; Schiehser Guy A; Fidock David A; Jacobus David P; Sacchettini James C
Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.
Bioorganic & medicinal chemistry letters 2006;16(8):2163-9.
2006: Morbidoni Hector R; Vilchèze Catherine; Kremer Laurent; Bittman Robert; Sacchettini James C; Jacobs William R
Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids.
Chemistry & biology 2006;13(3):297-307.
2006: Banaiee Niaz; Kincaid Eleanor Z; Buchwald Ulrike; Jacobs William R; Ernst Joel D
Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3019-27.
2006: Govan V A; Christensen N D; Berkower C; Jacobs W R; Williamson A-L
Immunisation with recombinant BCG expressing the cottontail rabbit papillomavirus (CRPV) L1 gene provides protection from CRPV challenge.
Vaccine 2006;24(12):2087-93.
2006: Roy Eleanor; De Silva A Dharshan; Sambandamurthy Vasan K; Clark Simon O; Stavropoulos Evangelos; Jacobs William R; Brennan John; Chan John; Williams Ann; Colston M Joseph; Tascon Ricardo E
Induction of high levels of protective immunity in mice after vaccination using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis.
Immunology letters 2006;103(2):196-9.
2006: Cayabyab Mark J; Hovav Avi-Hai; Hsu Tsungda; Krivulka Georgia R; Lifton Michelle A; Gorgone Darci A; Fennelly Glenn J; Haynes Barton F; Jacobs William R; Letvin Norman L
Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env.
Journal of virology 2006;80(4):1645-52.
2005: Ojha Anil; Anand Mridula; Bhatt Apoorva; Kremer Laurent; Jacobs William R; Hatfull Graham F
GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria.
Cell 2005;123(5):861-73.
2005: Freundlich Joel S; Anderson John W; Sarantakis Dimitri; Shieh Hong-Ming; Yu Min; Valderramos Juan-Carlos; Lucumi Edinson; Kuo Mack; Jacobs William R; Fidock David A; Schiehser Guy A; Jacobus David P; Sacchettini James C
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.
Bioorganic & medicinal chemistry letters 2005;15(23):5247-52.
2005: Bhatt Apoorva; Kremer Laurent; Dai Annie Z; Sacchettini James C; Jacobs William R
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.
Journal of bacteriology 2005;187(22):7596-606.
2005: Sambandamurthy Vasan K; Jacobs William R
Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis.
Microbes and infection / Institut Pasteur 2005;7(5-6):955-61.
2005: Colangeli Roberto; Helb Danica; Sridharan Sudharsan; Sun Jingchuan; Varma-Basil Mandira; Hazbón Manzour Hernando; Harbacheuski Ryhor; Megjugorac Nicholas J; Jacobs William R; Holzenburg Andreas; Sacchettini James C; Alland David
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.
Molecular microbiology 2005;55(6):1829-40.
2005: Vilchèze Catherine; Weisbrod Torin R; Chen Bing; Kremer Laurent; Hazbón Manzour H; Wang Feng; Alland David; Sacchettini James C; Jacobs William R
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.
Antimicrobial agents and chemotherapy 2005;49(2):708-20.
2005: Sambandamurthy Vasan K; Derrick Steven C; Jalapathy Kripa V; Chen Bing; Russell Robert G; Morris Sheldon L; Jacobs William R
Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.
Infection and immunity 2005;73(2):1196-203.
2004: Matsunaga Isamu; Bhatt Apoorva; Young David C; Cheng Tan-Yun; Eyles Stephen J; Besra Gurdyal S; Briken Volker; Porcelli Steven A; Costello Catherine E; Jacobs William R; Moody D Branch
Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells.
The Journal of experimental medicine 2004;200(12):1559-69.
2004: Lee Sunhee; Kriakov Jordan; Vilcheze Catherine; Dai Zhiyan; Hatfull Graham F; Jacobs William R
Bxz1, a new generalized transducing phage for mycobacteria.
FEMS microbiology letters 2004;241(2):271-6.
2004: Hisert Katherine B; Kirksey Meghan A; Gomez James E; Sousa Alexandra O; Cox Jeffery S; Jacobs William R; Nathan Carl F; McKinney John D
Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening.
Infection and immunity 2004;72(9):5315-21.
2004: Vecino William H; Quanquin Natalie M; Martinez-Sobrido Luis; Fernandez-Sesma Ana; García-Sastre Adolfo; Jacobs William R; Fennelly Glenn J
Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge.
Virology 2004;325(2):192-9.
2004: Glatman-Freedman Aharona; Casadevall Arturo; Dai Zongdong; Jacobs William R; Li Anping; Morris Sheldon L; Navoa Josepine Anne D; Piperdi Sajida; Robbins John B; Schneerson Rachel; Schwebach J Reid; Shapiro Michael
Antigenic evidence of prevalence and diversity of Mycobacterium tuberculosis arabinomannan.
Journal of clinical microbiology 2004;42(7):3225-31.
2004: Zimhony Oren; Vilchèze Catherine; Jacobs William R
Characterization of Mycobacterium smegmatis expressing the Mycobacterium tuberculosis fatty acid synthase I (fas1) gene.
Journal of bacteriology 2004;186(13):4051-5.
2004: Sampson Samantha L; Dascher Christopher C; Sambandamurthy Vasan K; Russell Robert G; Jacobs William R; Bloom Barry R; Hondalus Mary K
Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs.
Infection and immunity 2004;72(5):3031-7.
2004: Dao D N; Kremer L; Guérardel Y; Molano A; Jacobs W R; Porcelli S A; Briken V
Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages.
Infection and immunity 2004;72(4):2067-74.
2004: Tufariello JoAnn M; Jacobs William R; Chan John
Individual Mycobacterium tuberculosis resuscitation-promoting factor homologues are dispensable for growth in vitro and in vivo.
Infection and immunity 2004;72(1):515-26.
2003: Hsu Tsungda; Hingley-Wilson Suzanne M; Chen Bing; Chen Mei; Dai Annie Z; Morin Paul M; Marks Carolyn B; Padiyar Jeevan; Goulding Celia; Gingery Mari; Eisenberg David; Russell Robert G; Derrick Steven C; Collins Frank M; Morris Sheldon L; King C Harold; Jacobs William R
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12420-5.
2003: Hazbón Manzour Hernando; Guarín Nora; Ferro Beatriz Eugenia; Rodríguez Ana Lucía; Labrada Luz Angela; Tovar Rafael; Riska Paul F; Jacobs William R
Photographic and luminometric detection of luciferase reporter phages for drug susceptibility testing of clinical Mycobacterium tuberculosis isolates.
Journal of clinical microbiology 2003;41(10):4865-9.
2003: Hingley-Wilson Suzanne M; Sambandamurthy Vasan K; Jacobs William R
Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis.
Nature immunology 2003;4(10):949-55.
2003: Otero Joel; Jacobs William R; Glickman Michael S
Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction.
Applied and environmental microbiology 2003;69(9):5039-44.
2003: Ohno Hideaki; Zhu Guofeng; Mohan Vellore P; Chu Darien; Kohno Shigeru; Jacobs William R; Chan John
The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis.
Cellular microbiology 2003;5(9):637-48.
2003: Consaul Sandra A; Jacobs William R; Pavelka Martin S
Extragenic suppression of the requirement for diaminopimelate in diaminopimelate auxotrophs of Mycobacterium smegmatis.
FEMS microbiology letters 2003;225(1):131-5.
2003: Kriakov Jordan; Lee Sun hee; Jacobs William R
Identification of a regulated alkaline phosphatase, a cell surface-associated lipoprotein, in Mycobacterium smegmatis.
Journal of bacteriology 2003;185(16):4983-91.
2003: Banaiee Niaz; Bobadilla-del-Valle Miriam; Riska Paul F; Bardarov Svetoslav; Small Peter M; Ponce-de-Leon Alfredo; Jacobs William R; Hatfull Graham F; Sifuentes-Osornio Jose
Rapid identification and susceptibility testing of Mycobacterium tuberculosis from MGIT cultures with luciferase reporter mycobacteriophages.
Journal of medical microbiology 2003;52(Pt 7):557-61.
2003: Kremer Laurent; Dover Lynn G; Morbidoni Hector R; Vilchèze Catherine; Maughan William N; Baulard Alain; Tu Shiao-Chun; Honoré Nadine; Deretic Vojo; Sacchettini James C; Locht Camille; Jacobs William R; Besra Gurdyal S
Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
The Journal of biological chemistry 2003;278(23):20547-54.
2003: Kuo Mack R; Morbidoni Hector R; Alland David; Sneddon Scott F; Gourlie Brian B; Staveski Mark M; Leonard Marina; Gregory Jill S; Janjigian Andrew D; Yee Christopher; Musser James M; Kreiswirth Barry; Iwamoto Hiroyuki; Perozzo Remo; Jacobs William R; Sacchettini James C; Fidock David A
Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.
The Journal of biological chemistry 2003;278(23):20851-9.
2003: Bhatt Apoorva; Jacobs William R
Conjugal rites of mycobacteria.
Nature genetics 2003;34(1):3-4.
2003: Gokulan Kuppan; Rupp Bernhard; Pavelka Martin S; Jacobs William R; Sacchettini James C
Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis.
The Journal of biological chemistry 2003;278(20):18588-96.
2003: Pedulla Marisa L; Ford Michael E; Houtz Jennifer M; Karthikeyan Tharun; Wadsworth Curtis; Lewis John A; Jacobs-Sera Debbie; Falbo Jacob; Gross Joseph; Pannunzio Nicholas R; Brucker William; Kumar Vanaja; Kandasamy Jayasankar; Keenan Lauren; Bardarov Svetsoslav; Kriakov Jordan; Lawrence Jeffrey G; Jacobs William R; Hendrix Roger W; Hatfull Graham F
Origins of highly mosaic mycobacteriophage genomes.
Cell 2003;113(2):171-82.
2003: Braunstein Miriam; Espinosa Benjamin J; Chan John; Belisle John T; Jacobs William R
SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis.
Molecular microbiology 2003;48(2):453-64.
2003: Sharma Vivek; Arockiasamy Arulandu; Ronning Donald R; Savva Christos G; Holzenburg Andreas; Braunstein Miriam; Jacobs William R; Sacchettini James C
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2243-8.
2003: Bardarov Svetoslav; Dou Horng; Eisenach Katherine; Banaiee Niaz; Ya S u; Chan John; Jacobs William R; Riska Paul F
Detection and drug-susceptibility testing of M. tuberculosis from sputum samples using luciferase reporter phage: comparison with the Mycobacteria Growth Indicator Tube (MGIT) system.
Diagnostic microbiology and infectious disease 2003;45(1):53-61.
2003: Terwilliger T C; Park M S; Waldo G S; Berendzen J; Hung L-W; Kim C-Y; Smith C V; Sacchettini J C; Bellinzoni M; Bossi R; De Rossi E; Mattevi A; Milano A; Riccardi G; Rizzi M; Roberts M M; Coker A R; Fossati G; Mascagni P; Coates A R M; Wood S P; Goulding C W; Apostol M I; Anderson D H; Gill H S; Eisenberg D S; Taneja B; Mande S; Pohl E; Lamzin V; Tucker P; Wilmanns M; Colovos C; Meyer-Klaucke W; Munro A W; McLean K J; Marshall K R; Leys D; Yang J K; Yoon H-J; Lee B I; Lee M G; Kwak J E; Han B W; Lee J Y; Baek S-H; Suh S W; Komen M M; Arcus V L; Baker E N; Lott J S; Jacobs W; Alber T; Rupp B
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.
Tuberculosis (Edinburgh, Scotland) 2003;83(4):223-49.
2002: Larsen Michelle H; Vilchèze Catherine; Kremer Laurent; Besra Gurdyal S; Parsons Linda; Salfinger Max; Heifets Leonid; Hazbon Manzour H; Alland David; Sacchettini James C; Jacobs William R
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
Molecular microbiology 2002;46(2):453-66.
2002: Sambandamurthy Vasan K; Wang Xiaojuan; Chen Bing; Russell Robert G; Derrick Steven; Collins Frank M; Morris Sheldon L; Jacobs William R
A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis.
Nature medicine 2002;8(10):1171-4.
2002: Schwebach J Reid; Chen Bing; Glatman-Freedman Aharona; Casadevall Arturo; McKinney John D; Harb John L; McGuire Patrick J; Barkley W Emmett; Bloom Barry R; Jacobs William R
Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility.
Applied and environmental microbiology 2002;68(9):4646-9.
2002: Vecino William H; Morin Paul M; Agha Rabia; Jacobs William R; Fennelly Glenn J
Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV.
Immunology letters 2002;82(3):197-204.
2002: Goulding Celia W; Apostol Marcin; Anderson Daniel H; Gill Harindarpal S; Smith Clare V; Kuo Mack R; Yang Jin Kuk; Waldo Geoffrey S; Suh Se Won; Chauhan Radha; Kale Avinash; Bachhawat Nandita; Mande Shekhar C; Johnston Jodie M; Lott J Shaun; Baker Edward N; Arcus Vickery L; Leys David; McLean Kirsty J; Munro Andrew W; Berendzen Joel; Sharma Vivek; Park Min S; Eisenberg David; Sacchettini James; Alber Tom; Rupp Bernhard; Jacobs William; Terwilliger Thomas C
The TB structural genomics consortium: providing a structural foundation for drug discovery.
Current drug targets. Infectious disorders 2002;2(2):121-41.
2002: Perozzo Remo; Kuo Mack; Sidhu Amar bir Singh; Valiyaveettil Jacob T; Bittman Robert; Jacobs William R; Fidock David A; Sacchettini James C
Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase.
The Journal of biological chemistry 2002;277(15):13106-14.
2002: Steyn Adrie J C; Collins Desmond M; Hondalus Mary K; Jacobs William R; Kawakami R Pamela; Bloom Barry R
Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3147-52.
2002: Huang Chih-chin; Smith Clare V; Glickman Michael S; Jacobs William R; Sacchettini James C
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.
The Journal of biological chemistry 2002;277(13):11559-69.
2002: Wooff Esen; Michell Stephen L I; Gordon Stephen V; Chambers Mark A; Bardarov Stoyan; Jacobs William R; Hewinson R Glyn; Wheeler Paul R
Functional genomics reveals the sole sulphate transporter of the Mycobacterium tuberculosis complex and its relevance to the acquisition of sulphur in vivo.
Molecular microbiology 2002;43(3):653-63.
2002: Braunstein Miriam; Bardarov Stoyan S; Jacobs William R
Genetic methods for deciphering virulence determinants of Mycobacterium tuberculosis.
Methods in enzymology 2002;358():67-99.
2001: Braunstein M; Brown A M; Kurtz S; Jacobs W R
Two nonredundant SecA homologues function in mycobacteria.
Journal of bacteriology 2001;183(24):6979-90.
2001: Brennan M J; Delogu G; Chen Y; Bardarov S; Kriakov J; Alavi M; Jacobs W R
Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells.
Infection and immunity 2001;69(12):7326-33.
2001: Banaiee N; Bobadilla-Del-Valle M; Bardarov S; Riska P F; Small P M; Ponce-De-Leon A; Jacobs W R; Hatfull G F; Sifuentes-Osornio J
Luciferase reporter mycobacteriophages for detection, identification, and antibiotic susceptibility testing of Mycobacterium tuberculosis in Mexico.
Journal of clinical microbiology 2001;39(11):3883-8.
2001: Raman S; Song T; Puyang X; Bardarov S; Jacobs W R; Husson R N
The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis.
Journal of bacteriology 2001;183(20):6119-25.
2001: Glickman M S; Jacobs W R
Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline.
Cell 2001;104(4):477-85.
2001: Schwebach J R; Jacobs W R; Casadevall A
Sterilization of Mycobacterium tuberculosis Erdman samples by antimicrobial fixation in a biosafety level 3 laboratory.
Journal of clinical microbiology 2001;39(2):769-71.
2001: Glickman M S; Cahill S M; Jacobs W R
The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase.
The Journal of biological chemistry 2001;276(3):2228-33.
2000: Mediavilla J; Jain S; Kriakov J; Ford M E; Duda R L; Jacobs W R; Hendrix R W; Hatfull G F
Genome organization and characterization of mycobacteriophage Bxb1.
Molecular microbiology 2000;38(5):955-70.
2000: Chambers M A; Williams A; Gavier-Widén D; Whelan A; Hall G; Marsh P D; Bloom B R; Jacobs W R; Hewinson R G
Identification of a Mycobacterium bovis BCG auxotrophic mutant that protects guinea pigs against M. bovis and hematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin.
Infection and immunity 2000;68(12):7094-9.
2000: Zimhony O; Cox J S; Welch J T; Vilchèze C; Jacobs W R
Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis.
Nature medicine 2000;6(9):1043-7.
2000: McKinney J D; Höner zu Bentrup K; Muñoz-Elías E J; Miczak A; Chen B; Chan W T; Swenson D; Sacchettini J C; Jacobs W R; Russell D G
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
Nature 2000;406(6797):735-8.
2000: Sharma V; Sharma S; Hoener zu Bentrup K; McKinney J D; Russell D G; Jacobs W R; Sacchettini J C
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.
Nature structural biology 2000;7(8):663-8.
2000: Vilchèze C; Morbidoni H R; Weisbrod T R; Iwamoto H; Kuo M; Sacchettini J C; Jacobs W R
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.
Journal of bacteriology 2000;182(14):4059-67.
2000: Kremer L; Douglas J D; Baulard A R; Morehouse C; Guy M R; Alland D; Dover L G; Lakey J H; Jacobs W R; Brennan P J; Minnikin D E; Besra G S
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.
The Journal of biological chemistry 2000;275(22):16857-64.
2000: Braunstein M; Griffin TJ I V; Kriakov J I; Friedman S T; Grindley N D; Jacobs W R
Identification of genes encoding exported Mycobacterium tuberculosis proteins using a Tn552'phoA in vitro transposition system.
Journal of bacteriology 2000;182(10):2732-40.
2000: Hondalus M K; Bardarov S; Russell R; Chan J; Jacobs W R; Bloom B R
Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis.
Infection and immunity 2000;68(5):2888-98.
2000: Glickman M S; Cox J S; Jacobs W R
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.
Molecular cell 2000;5(4):717-27.
2000: Alland D; Steyn A J; Weisbrod T; Aldrich K; Jacobs W R
Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition.
Journal of bacteriology 2000;182(7):1802-11.
2000: Riska P F; Jacobs W R; Alland D
Molecular determinants of drug resistance in tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2000;4(2 Suppl 1):S4-10.
2000: Piatek A S; Telenti A; Murray M R; El-Hajj H; Jacobs W R; Kramer F R; Alland D
Genotypic analysis of Mycobacterium tuberculosis in two distinct populations using molecular beacons: implications for rapid susceptibility testing.
Antimicrobial agents and chemotherapy 2000;44(1):103-10.
1999: Cox J S; Chen B; McNeil M; Jacobs W R
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice.
Nature 1999;402(6757):79-83.
1999: Pavelka M S; Jacobs W R
Comparison of the construction of unmarked deletion mutations in Mycobacterium smegmatis, Mycobacterium bovis bacillus Calmette-Guérin, and Mycobacterium tuberculosis H37Rv by allelic exchange.
Journal of bacteriology 1999;181(16):4780-9.
1999: Dussurget O; Timm J; Gomez M; Gold B; Yu S; Sabol S Z; Holmes R K; Jacobs W R; Smith I
Transcriptional control of the iron-responsive fxbA gene by the mycobacterial regulator IdeR.
Journal of bacteriology 1999;181(11):3402-8.
1999: Riska P F; Su Y; Bardarov S; Freundlich L; Sarkis G; Hatfull G; Carrière C; Kumar V; Chan J; Jacobs W R
Rapid film-based determination of antibiotic susceptibilities of Mycobacterium tuberculosis strains by using a luciferase reporter phage and the Bronx Box.
Journal of clinical microbiology 1999;37(4):1144-9.
1999: Daugelat S; Jacobs W R
The Mycobacterium tuberculosis recA intein can be used in an ORFTRAP to select for open reading frames.
Protein science : a publication of the Protein Society 1999;8(3):644-53.
1999: Bange F C; Collins F M; Jacobs W R
Survival of mice infected with Mycobacterium smegmatis containing large DNA fragments from Mycobacterium tuberculosis.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 1999;79(3):171-80.
1998: Banerjee A; Sugantino M; Sacchettini J C; Jacobs W R
The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.
Microbiology (Reading, England) 1998;144 ( Pt 10)():2697-704.
1998: Alland D; Kramnik I; Weisbrod T R; Otsubo L; Cerny R; Miller L P; Jacobs W R; Bloom B R
Identification of differentially expressed mRNA in prokaryotic organisms by customized amplification libraries (DECAL): the effect of isoniazid on gene expression in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13227-32.
1998: Basso L A; Zheng R; Musser J M; Jacobs W R; Blanchard J S
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
The Journal of infectious diseases 1998;178(3):769-75.
1998: Yu S; Fiss E; Jacobs W R
Analysis of the exochelin locus in Mycobacterium smegmatis: biosynthesis genes have homology with genes of the peptide synthetase family.
Journal of bacteriology 1998;180(17):4676-85.
1998: Miesel L; Weisbrod T R; Marcinkeviciene J A; Bittman R; Jacobs W R
NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis.
Journal of bacteriology 1998;180(9):2459-67.
1998: Klabunde T; Sharma S; Telenti A; Jacobs W R; Sacchettini J C
Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing.
Nature structural biology 1998;5(1):31-6.
1998: Rozwarski D A; Grant G A; Barton D H; Jacobs W R; Sacchettini J C
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
Science (New York, N.Y.) 1998;279(5347):98-102.
1998: Miesel L; Rozwarski D A; Sacchettini J C; Jacobs W R
Mechanisms for isoniazid action and resistance.
Novartis Foundation symposium 1998;217():209-20; discussion 220-1.
1998: Riska P F; Jacobs W R
The use of luciferase-reporter phage for antibiotic-susceptibility testing of mycobacteria.
Methods in molecular biology (Clifton, N.J.) 1998;101():431-55.
1997: Carrière C; Riska P F; Zimhony O; Kriakov J; Bardarov S; Burns J; Chan J; Jacobs W R
Conditionally replicating luciferase reporter phages: improved sensitivity for rapid detection and assessment of drug susceptibility of Mycobacterium tuberculosis.
Journal of clinical microbiology 1997;35(12):3232-9.
1997: Riska P F; Jacobs W R; Bloom B R; McKitrick J; Chan J
Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: use of p-nitro-alpha-acetylamino-beta-hydroxy propiophenone.
Journal of clinical microbiology 1997;35(12):3225-31.
1997: Telenti A; Southworth M; Alcaide F; Daugelat S; Jacobs W R; Perler F B
The Mycobacterium xenopi GyrA protein splicing element: characterization of a minimal intein.
Journal of bacteriology 1997;179(20):6378-82.
1997: Bardarov S; Kriakov J; Carriere C; Yu S; Vaamonde C; McAdam R A; Bloom B R; Hatfull G F; Jacobs W R
Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10961-6.
1997: Pelicic V; Jackson M; Reyrat J M; Jacobs W R; Gicquel B; Guilhot C
Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10955-60.
1997: Sreevatsan S; Stockbauer K E; Pan X; Kreiswirth B N; Moghazeh S L; Jacobs W R; Telenti A; Musser J M
Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.
Antimicrobial agents and chemotherapy 1997;41(8):1677-81.
1997: Telenti A; Philipp W J; Sreevatsan S; Bernasconi C; Stockbauer K E; Wieles B; Musser J M; Jacobs W R
The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol.
Nature medicine 1997;3(5):567-70.
1997: Cirillo J D; Weisbrod T R; Banerjee A; Bloom B R; Jacobs W R
Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria.
Journal of bacteriology 1997;179(8):2792.
1997: Pavelka M S; Weisbrod T R; Jacobs W R
Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis.
Journal of bacteriology 1997;179(8):2777-82.
1997: Tuckman D; Donnelly R J; Zhao F X; Jacobs W R; Connell N D
Interruption of the phosphoglucose isomerase gene results in glucose auxotrophy in Mycobacterium smegmatis.
Journal of bacteriology 1997;179(8):2724-30.
1996: Pearson R E; Jurgensen S; Sarkis G J; Hatfull G F; Jacobs W R
Construction of D29 shuttle phasmids and luciferase reporter phages for detection of mycobacteria.
Gene 1996;183(1-2):129-36.
1996: Pavelka M S; Jacobs W R
Biosynthesis of diaminopimelate, the precursor of lysine and a component of peptidoglycan, is an essential function of Mycobacterium smegmatis.
Journal of bacteriology 1996;178(22):6496-507.
1996: Jacobs W; Brennan P; Curlin G; Ginsberg A; Adams M; Fleischmann R; Fraser C; Venter J C; Shinnick T; Bishai W; Smith H; Stover K; Hatfull G
Comparative sequencing.
Science (New York, N.Y.) 1996;274(5284):17-8.
1996: Hewinson R G; Michell S L; Russell W P; McAdam R A; Jacobs W R
Molecular characterization of MPT83: a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70.
Scandinavian journal of immunology 1996;43(5):490-9.
1996: Bange F C; Brown A M; Jacobs W R
Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages.
Infection and immunity 1996;64(5):1794-9.
1996: Dubnau E; Soares S; Huang T J; Jacobs W R
Overproduction of mycobacterial ribosomal protein S13 induces catalase/peroxidase activity and hypersensitivity to isoniazid in Mycobacterium smegmatis.
Gene 1996;170(1):17-22.
1996: Philipp W J; Poulet S; Eiglmeier K; Pascopella L; Balasubramanian V; Heym B; Bergh S; Bloom B R; Jacobs W R; Cole S T
An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):3132-7.
1996: Guleria I; Teitelbaum R; McAdam R A; Kalpana G; Jacobs W R; Bloom B R
Auxotrophic vaccines for tuberculosis.
Nature medicine 1996;2(3):334-7.
1996: Takiff H E; Cimino M; Musso M C; Weisbrod T; Martinez R; Delgado M B; Salazar L; Bloom B R; Jacobs W R
Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):362-6.
1996: Balasubramanian V; Pavelka M S; Bardarov S S; Martin J; Weisbrod T R; McAdam R A; Bloom B R; Jacobs W R
Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates.
Journal of bacteriology 1996;178(1):273-9.
1996: Jacobs W R
Science for combatting tuberculosis.
Bulletin of the New York Academy of Medicine 1996;73(1):46-52.
1995: Collins D M; Kawakami R P; de Lisle G W; Pascopella L; Bloom B R; Jacobs W R
Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):8036-40.
1995: Quémard A; Sacchettini J C; Dessen A; Vilcheze C; Bittman R; Jacobs W R; Blanchard J S
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.
Biochemistry 1995;34(26):8235-41.
1995: Falcone V; Bassey E; Jacobs W; Collins F
The immunogenicity of recombinant Mycobacterium smegmatis bearing BCG genes.
Microbiology (Reading, England) 1995;141 ( Pt 5)():1239-45.
1995: Cirillo J D; Stover C K; Bloom B R; Jacobs W R; Barletta R G
Bacterial vaccine vectors and bacillus Calmette-Guérin.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1995;20(4):1001-9.
1995: Dessen A; Quémard A; Blanchard J S; Jacobs W R; Sacchettini J C
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science (New York, N.Y.) 1995;267(5204):1638-41.
1995: McAdam R A; Weisbrod T R; Martin J; Scuderi J D; Brown A M; Cirillo J D; Bloom B R; Jacobs W R
In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis.
Infection and immunity 1995;63(3):1004-12.
1995: Sarkis G J; Jacobs W R; Hatfull G F
L5 luciferase reporter mycobacteriophages: a sensitive tool for the detection and assay of live mycobacteria.
Molecular microbiology 1995;15(6):1055-67.
1995: Kapur V; Li L L; Hamrick M R; Plikaytis B B; Shinnick T M; Telenti A; Jacobs W R; Banerjee A; Cole S; Yuen K Y
Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing.
Archives of pathology & laboratory medicine 1995;119(2):131-8.
1994: Fiss E H; Yu S; Jacobs W R
Identification of genes involved in the sequestration of iron in mycobacteria: the ferric exochelin biosynthetic and uptake pathways.
Molecular microbiology 1994;14(3):557-69.
1994: Mills J A; McNeil M R; Belisle J T; Jacobs W R; Brennan P J
Loci of Mycobacterium avium ser2 gene cluster and their functions.
Journal of bacteriology 1994;176(16):4803-8.
1994: Cirillo J D; Weisbrod T R; Banerjee A; Bloom B R; Jacobs W R
Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria.
Journal of bacteriology 1994;176(14):4424-9.
1994: Heym B; Honoré N; Truffot-Pernot C; Banerjee A; Schurra C; Jacobs W R; van Embden J D; Grosset J H; Cole S T
Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study.
Lancet 1994;344(8918):293-8.
1994: Brunhuber N M; Banerjee A; Jacobs W R; Blanchard J S
Cloning, sequencing, and expression of Rhodococcus L-phenylalanine dehydrogenase. Sequence comparisons to amino-acid dehydrogenases.
The Journal of biological chemistry 1994;269(23):16203-11.
1994: Pascopella L; Collins F M; Martin J M; Lee M H; Hatfull G F; Stover C K; Bloom B R; Jacobs W R
Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence.
Infection and immunity 1994;62(4):1313-9.
1994: Takiff H E; Salazar L; Guerrero C; Philipp W; Huang W M; Kreiswirth B; Cole S T; Jacobs W R; Telenti A
Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations.
Antimicrobial agents and chemotherapy 1994;38(4):773-80.
1994: Bloom B R; Jacobs W R; Clark-Curtiss J E
Leprosy vaccine.
Nature 1994;368(6472):579.
1994: Cirillo J D; Weisbrod T R; Pascopella L; Bloom B R; Jacobs W R
Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria.
Molecular microbiology 1994;11(4):629-39.
1994: Banerjee A; Dubnau E; Quemard A; Balasubramanian V; Um K S; Wilson T; Collins D; de Lisle G; Jacobs W R
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.
Science (New York, N.Y.) 1994;263(5144):227-30.
1993: Ellner J J; Hinman A R; Dooley S W; Fischl M A; Sepkowitz K A; Goldberger M J; Shinnick T M; Iseman M D; Jacobs W R
Tuberculosis symposium: emerging problems and promise.
The Journal of infectious diseases 1993;168(3):537-51.
1993: Pascopella L; Collins F M; Martin J M; Jacobs W R; Bloom B R
Identification of a genomic fragment of Mycobacterium tuberculosis responsible for in vivo growth advantage.
Infectious agents and disease 1993;2(4):282-4.
1993: Cooksey R C; Crawford J T; Jacobs W R; Shinnick T M
A rapid method for screening antimicrobial agents for activities against a strain of Mycobacterium tuberculosis expressing firefly luciferase.
Antimicrobial agents and chemotherapy 1993;37(6):1348-52.
1993: Averill L E; Cavallo U; Wallis R S; Boom W H; Bona M; Mincek M; Pascopella L; Jacobs W R; Ellner J J
Screening of a cosmid library of Mycobacterium bovis BCG in Mycobacterium smegmatis for novel T-cell stimulatory antigens.
Research in microbiology 1993;144(5):349-62.
1993: Belisle J T; Klaczkiewicz K; Brennan P J; Jacobs W R; Inamine J M
Rough morphological variants of Mycobacterium avium. Characterization of genomic deletions resulting in the loss of glycopeptidolipid expression.
The Journal of biological chemistry 1993;268(14):10517-23.
1993: Jacobs W R; Barletta R G; Udani R; Chan J; Kalkut G; Sosne G; Kieser T; Sarkis G J; Hatfull G F; Bloom B R
Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages.
Science (New York, N.Y.) 1993;260(5109):819-22.
1993: Donnelly-Wu M K; Jacobs W R; Hatfull G F
Superinfection immunity of mycobacteriophage L5: applications for genetic transformation of mycobacteria.
Molecular microbiology 1993;7(3):407-17.
1992: Connell N; Stover C K; Jacobs W R
Old microbes with new faces: molecular biology and the design of new vaccines.
Current opinion in immunology 1992;4(4):442-8.
1992: Jacobs W R
Advances in mycobacterial genetics: new promises for old diseases.
Immunobiology 1992;184(2-3):147-56.
1992: Barletta R G; Kim D D; Snapper S B; Bloom B R; Jacobs W R
Identification of expression signals of the mycobacteriophages Bxb1, L1 and TM4 using the Escherichia-Mycobacterium shuttle plasmids pYUB75 and pYUB76 designed to create translational fusions to the lacZ gene.
Journal of general microbiology 1992;138(1):23-30.
1992: Stover C K; de la Cruz V F; Bansal G P; Hanson M S; Fuerst T R; Jacobs W R; Bloom B R
Use of recombinant BCG as a vaccine delivery vehicle.
Advances in experimental medicine and biology 1992;327():175-82.
1991: Cirillo J D; Barletta R G; Bloom B R; Jacobs W R
A novel transposon trap for mycobacteria: isolation and characterization of IS1096.
Journal of bacteriology 1991;173(24):7772-80.
1991: Belisle J T; Pascopella L; Inamine J M; Brennan P J; Jacobs W R
Isolation and expression of a gene cluster responsible for biosynthesis of the glycopeptidolipid antigens of Mycobacterium avium.
Journal of bacteriology 1991;173(21):6991-7.
1991: Kalpana G V; Bloom B R; Jacobs W R
Insertional mutagenesis and illegitimate recombination in mycobacteria.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5433-7.
1991: Lee M H; Pascopella L; Jacobs W R; Hatfull G F
Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guérin.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3111-5.
1991: Sirawaraporn W; Sirawaraporn R; Chanpongsri A; Jacobs W R; Santi D V
Purification and characterization of dihydrofolate reductase from wild-type and trimethoprim-resistant Mycobacterium smegmatis.
Experimental parasitology 1991;72(2):184-90.
1991: Jacobs W R; Kalpana G V; Cirillo J D; Pascopella L; Snapper S B; Udani R A; Jones W; Barletta R G; Bloom B R
Genetic systems for mycobacteria.
Methods in enzymology 1991;204():537-55.
1990: Snapper S B; Melton R E; Mustafa S; Kieser T; Jacobs W R
Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis.
Molecular microbiology 1990;4(11):1911-9.
1990: Barletta R G; Snapper B; Cirillo J D; Connell N D; Kim D D; Jacobs W R; Bloom B R
Recombinant BCG as a candidate oral vaccine vector.
Research in microbiology 1990;141(7-8):931-9.
1990: Jacobs W R; Snapper S B; Lugosi L; Bloom B R
Development of BCG as a recombinant vaccine vehicle.
Current topics in microbiology and immunology 1990;155():153-60.
1989: Lugosi L; Jacobs W R; Bloom B R
Genetic transformation of BCG.
Tubercle 1989;70(3):159-70.
1989: Grosskinsky C M; Jacobs W R; Clark-Curtiss J E; Bloom B R
Genetic relationships among Mycobacterium leprae, Mycobacterium tuberculosis, and candidate leprosy vaccine strains determined by DNA hybridization: identification of an M. leprae-specific repetitive sequence.
Infection and immunity 1989;57(5):1535-41.
1989: Jacobs W R; Snapper S B; Tuckman M; Bloom B R
Mycobacteriophage vector systems.
Reviews of infectious diseases 1989;11 Suppl 2():S404-10.
1989: Bloom B R; Jacobs W R
New strategies for leprosy and tuberculosis and for development of bacillus Calmette-Guérin into a multivaccine vehicle.
Annals of the New York Academy of Sciences 1989;569():155-73.
1989: Lugosi L; Jacobs W; Bloom B R
Transformation of BCG with plasmid DNA.
Acta leprologica 1989;7 Suppl 1():256-7.
1989: Jacobs W R; Snapper S B; Lugosi L; Jekkel A; Melton R E; Kieser T; Bloom B R
Development of genetic systems for the mycobacteria.
Acta leprologica 1989;7 Suppl 1():203-7.
1988: Snapper S B; Lugosi L; Jekkel A; Melton R E; Kieser T; Bloom B R; Jacobs W R
Lysogeny and transformation in mycobacteria: stable expression of foreign genes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):6987-91.
1987: Jacobs W R; Tuckman M; Bloom B R
Introduction of foreign DNA into mycobacteria using a shuttle phasmid.
Nature 1987;327(6122):532-5.
1986: Jacobs W R; Barrett J F; Clark-Curtiss J E; Curtiss R
In vivo repackaging of recombinant cosmid molecules for analyses of Salmonella typhimurium, Streptococcus mutans, and mycobacterial genomic libraries.
Infection and immunity 1986;52(1):101-9.
1986: Jacobs W R; Docherty M A; Curtiss R; Clark-Curtiss J E
Expression of Mycobacterium leprae genes from a Streptococcus mutans promoter in Escherichia coli K-12.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1926-30.
1985: Clark-Curtiss J E; Jacobs W R; Docherty M A; Ritchie L R; Curtiss R
Molecular analysis of DNA and construction of genomic libraries of Mycobacterium leprae.
Journal of bacteriology 1985;161(3):1093-102.

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