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David Cane

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Publications

TOP 3
L Sangeetha Vedula; Jiaoyang Jiang; Tatiana Zakharian; David E Cane; David W Christianson
Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif.
L Sangeetha Vedula; Yuxin Zhao; Robert M Coates; Tanetoshi Koyama; David E Cane; David W Christianson
Exploring biosynthetic diversity with trichodiene synthase.
Ekaterina Y Shishova; Luigi Di Costanzo; David E Cane; David W Christianson
X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.

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All Publications

2008: L Sangeetha Vedula; Jiaoyang Jiang; Tatiana Zakharian; David E Cane; David W Christianson
Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233-Mg2+B motif.
Archives of biochemistry and biophysics 2008;469(2):184-94.
2007: L Sangeetha Vedula; Yuxin Zhao; Robert M Coates; Tanetoshi Koyama; David E Cane; David W Christianson
Exploring biosynthetic diversity with trichodiene synthase.
Archives of biochemistry and biophysics 2007;466(2):260-6.
2007: Ekaterina Y Shishova; Luigi Di Costanzo; David E Cane; David W Christianson
X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate.
Biochemistry 2007;46(7):1941-51.
2005: L Sangeetha Vedula; David E Cane; David W Christianson
Role of arginine-304 in the diphosphate-triggered active site closure mechanism of trichodiene synthase.
Biochemistry 2005;44(38):12719-27.
2005: L Sangeetha Vedula; Michael J Rynkiewicz; Hyung-Jung Pyun; Robert M Coates; David E Cane; David W Christianson
Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants.
Biochemistry 2005;44(16):6153-63.
2002: Michael J Rynkiewicz; David E Cane; David W Christianson
X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity.
Biochemistry 2002;41(6):1732-41.
2001: Michael J Rynkiewicz; David E Cane; David W Christianson
Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13543-8.
2000: J M Caruthers; I Kang; Michael J Rynkiewicz; David E Cane; David W Christianson
Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti.
The Journal of biological chemistry 2000;275(33):25533-9.
1997: CA Lesburg; G Zhai; David E Cane; David W Christianson
Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology.
Science (New York, N.Y.) 1997;277(5333):1820-4.