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Masaharu Seno

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Guoliang Jin; Tomonari Kasai; Takayuki Kudoh; Akifumi Mizutani; Hiroshi Murakami; Takayuki Otani; Marta Prieto Vila; David S Salomon; Takayuki Fukuda; Satoshi Hirohata; Ting Yan; Masaharu Seno
Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Hideki Hashimoto; Yasunori Ikeda; Atsushi Itadani; Takayuki Kudoh; Yasushige Kuroda; Yoshihiro Kusano; Makoto Nakanishi; Masaharu Seno; Tatsuo Fujii; Jun Takada
Acidic amorphous silica prepared from iron oxide of bacterial origin.
Guoliang Jin; Tomonari Kasai; Takayuki Kudoh; Akifumi Mizutani; Hiroshi Murakami; Keisuke Nakanishi; David S Salomon; Ling Chen; Takayuki Fukuda; Satoshi Hirohata; Ting Yan; Masaharu Seno
Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway.

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2013: Guoliang Jin; Tomonari Kasai; Takayuki Kudoh; Akifumi Mizutani; Hiroshi Murakami; Takayuki Otani; Marta Prieto Vila; David S Salomon; Takayuki Fukuda; Satoshi Hirohata; Ting Yan; Masaharu Seno
Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Molecular biology reports 2013;40(4):3165-71.
2013: Hideki Hashimoto; Yasunori Ikeda; Atsushi Itadani; Takayuki Kudoh; Yasushige Kuroda; Yoshihiro Kusano; Makoto Nakanishi; Masaharu Seno; Tatsuo Fujii; Jun Takada
Acidic amorphous silica prepared from iron oxide of bacterial origin.
ACS applied materials & interfaces 2013;5(3):518-23.
2012: Guoliang Jin; Tomonari Kasai; Takayuki Kudoh; Akifumi Mizutani; Hiroshi Murakami; Keisuke Nakanishi; David S Salomon; Ling Chen; Takayuki Fukuda; Satoshi Hirohata; Ting Yan; Masaharu Seno
Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway.
Growth factors (Chur, Switzerland) 2012;30(5):344-55.
2012: Tomonari Kasai; Takayuki Kudoh; Akifumi Mizutani; Hiroshi Murakami; Keisuke Nakamura; Masashi Okada; Sreeja Sekhar; Ling Chen; Samah El-Ghlban; Arun Vaidyanath; Masaharu Seno
Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma Cell Motility via Receptor-Mediated Endocytosis.
Journal of drug delivery 2012;2012():975763.
2012: Ling Chen; Li Fu; Mary J C Hendrix; Guoliang Jin; Tomonari Kasai; Takayuki Kudoh; Yueguang Li; Akifumi Mizutani; Masashi Okada; David S Salomon; Ayano Satoh; Yuh Sugii; Arun Vaidyanath; Masaharu Seno
A model of cancer stem cells derived from mouse induced pluripotent stem cells.
PloS one 2012;7(4):e33544.
2011: Arun Vaidyanath; Jiyou Wang; Nao Takeyasu; Ling Chen; Li Fu; Toshihiro Hashizume; Tomonari Kasai; Takayuki Kudoh; Tadahiro Nagaoka; Ayano Satoh; Hitomi Satoh; Masaharu Seno
Enhanced internalization of ErbB2 in SK-BR-3 cells with multivalent forms of an artificial ligand.
Journal of cellular and molecular medicine 2011;15(11):2525-38.
2011: Kohei Hamamoto; Satoko Yamada; Akemi Hara; Tsutomu Kodera; Masaharu Seno; Itaru Kojima
Extracellular matrix modulates insulin production during differentiation of AR42J cells: functional role of Pax6 transcription factor.
Journal of cellular biochemistry 2011;112(1):318-29.
2010: Takayuki Otani; Toshihiro Hashizume; Tadahiro Nagaoka; Tomoko Fukuda; Careen K Tang; David S Salomon; Masaharu Seno
Production of biologically active IgG hinge-tag soluble epidermal growth factor receptors (ErbB).
Biotechnology letters 2010;32(3):361-6.
2009: Takayuki Fukuda; Miki Iwata; Midori Kitazoe; Takashi Maeda; David Salomon; Satoshi Hirohata; Katsuyuki Tanizawa; Shun'ichi Kuroda; Masaharu Seno
Human eosinophil cationic protein enhances stress fiber formation in Balb/c 3T3 fibroblasts and differentiation of rat neonatal cardiomyocytes.
Growth factors (Chur, Switzerland) 2009;27(4):228-36.
2009: Bin Feng; Kazuhito Tomizawa; Hiroyuki Michiue; Shin-ichi Miyatake; Xiao-Jian Han; Atsushi Fujimura; Masaharu Seno; Mitsunori Kirihata; Hideki Matsui
Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His.
Biomaterials 2009;30(9):1746-55.
2009: Tsutomu Kodera; Satoko Yamada; Yoritsuna Yamamoto; Akemi Hara; Yuji Tanaka; Masaharu Seno; Kazuo Umezawa; Izumi Takei; Itaru Kojima
Administration of conophylline and betacellulin-delta4 increases the beta-cell mass in neonatal streptozotocin-treated rats.
Endocrine journal 2009;56(6):799-806.
2008: Yuh Sugii; Hitomi Satoh; Dongwei Yu; Yasaburo Matsuura; Heizo Tokutaka; Masaharu Seno
Spherical self-organizing map as a helpful tool to identify category-specific cell surface markers.
Biochemical and biophysical research communications 2008;376(2):414-8.
2008: Hitoshi Murata; Junichiro Futami; Midori Kitazoe; Takayuki Yonehara; Hidetaka Nakanishi; Megumi Kosaka; Hiroko Tada; Masakiyo Sakaguchi; Yasuyuki Yagi; Masaharu Seno; Nam-ho Huh; Hidenori Yamada
Intracellular delivery of glutathione S-transferase-fused proteins into mammalian cells by polyethylenimine-glutathione conjugates.
Journal of biochemistry 2008;144(4):447-55.
2008: Morihisa Hirota; Kazuhide Watanabe; Shin Hamada; Youping Sun; Luigi Strizzi; Mario Mancino; Tadahiro Nagaoka; Monica Gonzales; Masaharu Seno; Caterina Bianco; David S Salomon
Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300.
Cellular signalling 2008;20(9):1632-41.
2008: Yoritsuna Yamamoto; Satoko Yamada; Tsutomu Kodera; Akemi Hara; Kazuo Motoyoshi; Yuji Tanaka; Tadahiro Nagaoka; Masaharu Seno; Itaru Kojima
Reversal of streptozotocin-induced hyperglycemia by continuous supply of betacellulin in mice.
Growth factors (Chur, Switzerland) 2008;26(4):173-9.
2008: Etsuko Hisanaga; Kee-Yong Park; Satoko Yamada; Hiromi Hashimoto; Toshiyuki Takeuchi; Masatomo Mori; Masaharu Seno; Kazuo Umezawa; Izumi Takei; Itaru Kojima
A simple method to induce differentiation of murine bone marrow mesenchymal cells to insulin-producing cells using conophylline and betacellulin-delta4.
Endocrine journal 2008;55(3):535-43.
2008: Toshihiro Hashizume; Takayuki Fukuda; Tadahiro Nagaoka; Hiroko Tada; Hidenori Yamada; Kazuhide Watanabe; David S Salomon; Masaharu Seno
Cell type dependent endocytic internalization of ErbB2 with an artificial peptide ligand that binds to ErbB2.
Cell biology international 2008;32(7):814-26.
2008: Tadahiro Nagaoka; Takayuki Fukuda; Toshihiro Hashizume; Tomoko Nishiyama; Hiroko Tada; Hidenori Yamada; David S Salomon; Satoko Yamada; Itaru Kojima; Masaharu Seno
A betacellulin mutant promotes differentiation of pancreatic acinar AR42J cells into insulin-producing cells with low affinity of binding to ErbB1.
Journal of molecular biology 2008;380(1):83-94.
2008: Nobuyuki Bokui; Takayuki Otani; Koichi Igarashi; Junichiro Kaku; Mitsuo Oda; Tadahiro Nagaoka; Masaharu Seno; Kenji Tatematsu; Toshihide Okajima; Takashi Matsuzaki; Kang Ting; Katsuyuki Tanizawa; Shun'ichi Kuroda
Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation.
FEBS letters 2008;582(2):365-71.
2008: Hitoshi Murata; Junichiro Futami; Midori Kitazoe; Megumi Kosaka; Hiroko Tada; Masaharu Seno; Hidenori Yamada
Transient cell proliferation with polyethylenimine-cationized N-terminal domain of simian virus 40 large T-antigen.
Journal of bioscience and bioengineering 2008;105(1):34-8.
2007: Kazuhide Watanabe; Caterina Bianco; Luigi Strizzi; Shin Hamada; Mario Mancino; Veronique Bailly; Wenjun Mo; Dingyi Wen; Konrad Miatkowski; Monica Gonzales; Michele Sanicola; Masaharu Seno; David S Salomon
Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
The Journal of biological chemistry 2007;282(43):31643-55.
2007: Yumi Tsutsui; Kazuhito Tomizawa; Mana Nagita; Hiroyuki Michiue; Tei-ichi Nishiki; Iori Ohmori; Masaharu Seno; Hideki Matsui
Development of bionanocapsules targeting brain tumors.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(2):159-64.
2007: Hidenori Yamada; Taro Tamada; Megumi Kosaka; Kohei Miyata; Shinya Fujiki; Masaru Tano; Masayuki Moriya; Mamoru Yamanishi; Eijiro Honjo; Hiroko Tada; Takeshi Ino; Hiroshi Yamaguchi; Junichiro Futami; Masaharu Seno; Takashi Nomoto; Tomoko Hirata; Motonobu Yoshimura; Ryota Kuroki
'Crystal lattice engineering,' an approach to engineer protein crystal contacts by creating intermolecular symmetry: crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines.
Protein science : a publication of the Protein Society 2007;16(7):1389-97.
2007: Tadahiro Nagaoka; Takayuki Fukuda; Shinnosuke Yoshida; Hirohito Nishimura; Dongwei Yu; Shun'ichi Kuroda; Katsuyuki Tanizawa; Akihiko Kondo; Masakazu Ueda; Hidenori Yamada; Hiroko Tada; Masaharu Seno
Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification.
Journal of controlled release : official journal of the Controlled Release Society 2007;118(3):348-56.
2007: Ryu-Ichi Kitamura; Takeki Ogata; Yuji Tanaka; Kazuo Motoyoshi; Masaharu Seno; Izumi Takei; Kazuo Umezawa; Itaru Kojima
Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
Endocrine journal 2007;54(2):255-64.
2007: Y Iwasaki; M Ueda; T Yamada; A Kondo; Masaharu Seno; K Tanizawa; S Kuroda; M Sakamoto; Masaki Kitajima
Gene therapy of liver tumors with human liver-specific nanoparticles.
Cancer gene therapy 2007;14(1):74-81.
2006: Hiroshi Yagi; Masakazu Ueda; Hiromitsu Jinno; Koichi Aiura; Shuji Mikami; Hiroko Tada; Masaharu Seno; Hidenori Yamada; Masaki Kitajima
Anti-tumor effect in an in vivo model by human-derived pancreatic RNase with basic fibroblast growth factor insertional fusion protein through antiangiogenic properties.
Cancer science 2006;97(12):1315-20.
2006: Takuya Shishido; Masaru Muraoka; Masakazu Ueda; Masaharu Seno; Katsuyuki Tanizawa; Shun'ichi Kuroda; Hideki Fukuda; Akihiko Kondo
Secretory production system of bionanocapsules using a stably transfected insect cell line.
Applied microbiology and biotechnology 2006;73(3):505-11.
2006: Michael P Sanderson; Catherine A Abbott; Hiroko Tada; Masaharu Seno; Peter J Dempsey; Andrew J Dunbar
Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding.
Journal of cellular biochemistry 2006;99(2):609-23.
2006: Hitoshi Murata; Masakiyo Sakaguchi; Junichiro Futami; Midori Kitazoe; Takashi Maeda; Hideki Doura; Megumi Kosaka; Hiroko Tada; Masaharu Seno; Nam-ho Huh; Hidenori Yamada
Denatured and reversibly cationized p53 readily enters cells and simultaneously folds to the functional protein in the cells.
Biochemistry 2006;45(19):6124-32.
2006: Sojun Hoshimoto; Masakazu Ueda; Hiromitsu Jinno; Masaki Kitajima; Junichiro Futami; Masaharu Seno
Mechanisms of the growth-inhibitory effect of the RNase-EGF fused protein against EGFR-overexpressing cells.
Anticancer research 2006;26(2A):857-63.
2006: Dongwei Yu; Takayuki Fukuda; Shun'ichi Kuroda; Katsuyuki Tanizawa; Akihiko Kondo; Masakazu Ueda; Tadanori Yamada; Hiroko Tada; Masaharu Seno
Engineered bio-nanocapsules, the selective vector for drug delivery system.
IUBMB life 2006;58(1):1-6.
2005: Takeki Ogata; Andrew J Dunbar; Yoritsuna Yamamoto; Yuji Tanaka; Masaharu Seno; Itaru Kojima
Betacellulin-delta4, a novel differentiation factor for pancreatic beta-cells, ameliorates glucose intolerance in streptozotocin-treated rats.
Endocrinology 2005;146(11):4673-81.
2005: Koichi Hirayama; Tadahiro Nagaoka; Dongwei Yu; Takayuki Fukuda; Hiroko Tada; Hidenori Yamada; Masaharu Seno
Identification of cell surface marker candidates on SV-T2 cells using DNA microarray on DLC-coated glass.
Biochemical and biophysical research communications 2005;334(1):263-8.
2005: Dongwei Yu; Chie Amano; Takayuki Fukuda; Tadanori Yamada; Shun'ichi Kuroda; Katsuyuki Tanizawa; Akihiko Kondo; Masakazu Ueda; Hidenori Yamada; Hiroko Tada; Masaharu Seno
The specific delivery of proteins to human liver cells by engineered bio-nanocapsules.
The FEBS journal 2005;272(14):3651-60.
2005: Tetsu Hayashida; Masakazu Ueda; Koichi Aiura; Hiroko Tada; Masayuki Onizuka; Masaharu Seno; Hidenori Yamada; Masaki Kitajima
Anti-angiogenic effect of an insertional fusion protein of human basic fibroblast growth factor and ribonuclease-1.
Protein engineering, design & selection : PEDS 2005;18(7):321-7.
2005: Midori Kitazoe; Hitoshi Murata; Junichiro Futami; Takashi Maeda; Masakiyo Sakaguchi; Masahiro Miyazaki; Megumi Kosaka; Hiroko Tada; Masaharu Seno; Nam-ho Huh; Masayoshi Namba; Mitsuo Nishikawa; Yoshitake Maeda; Hidenori Yamada
Protein transduction assisted by polyethylenimine-cationized carrier proteins.
Journal of biochemistry 2005;137(6):693-701.
2005: Junichiro Futami; Midori Kitazoe; Takashi Maeda; Emiko Nukui; Masakiyo Sakaguchi; Jun Kosaka; Masahiro Miyazaki; Megumi Kosaka; Hiroko Tada; Masaharu Seno; Junzo Sasaki; Nam-ho Huh; Masayoshi Namba; Hidenori Yamada
Intracellular delivery of proteins into mammalian living cells by polyethylenimine-cationization.
Journal of bioscience and bioengineering 2005;99(2):95-103.
2005: Satoko Yamada; Kunihiko Terada; Yasuharu Ueno; Toshihiro Sugiyama; Masaharu Seno; Itaru Kojima
Differentiation of adult hepatic stem-like cells into pancreatic endocrine cells.
Cell transplantation 2005;14(9):647-53.
2004: Luigi Strizzi; Caterina Bianco; Nicola Normanno; Masaharu Seno; Christian Wechselberger; Brenda Wallace-Jones; Nadia I Khan; Morihisa Hirota; Youping Sun; Michele Sanicola; David S Salomon
Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice.
Journal of cellular physiology 2004;201(2):266-76.
2004: Hiroko Tada; Masayuki Onizuka; Kazuko Muraki; Wataru Masuzawa; Junichiro Futami; Megumi Kosaka; Masaharu Seno; Hidenori Yamada
Insertional-fusion of basic fibroblast growth factor endowed ribonuclease 1 with enhanced cytotoxicity by steric blockade of inhibitor interaction.
FEBS letters 2004;568(1-3):39-43.
2004: Takeki Ogata; Kee Young Park; Masaharu Seno; Itaru Kojima
Reversal of streptozotocin-induced hyperglycemia by transplantation of pseudoislets consisting of beta cells derived from ductal cells.
Endocrine journal 2004;51(3):381-6.
2004: Tadanori Yamada; Masakazu Ueda; Masaharu Seno; Akihiko Kondo; Katsuyuki Tanizawa; Shun'ichi Kuroda
Novel tissue and cell type-specific gene/drug delivery system using surface engineered hepatitis B virus nano-particles.
Current drug targets. Infectious disorders 2004;4(2):163-7.
2004: Lei Li; Zhaohong Yi; Masaharu Seno; Itaru Kojima
Activin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats.
Diabetes 2004;53(3):608-15.
2003: Lei Li; Masaharu Seno; Hidenori Yamada; Itaru Kojima
Betacellulin improves glucose metabolism by promoting conversion of intraislet precursor cells to beta-cells in streptozotocin-treated mice.
American journal of physiology. Endocrinology and metabolism 2003;285(3):E577-83.
2003: Tadanori Yamada; Yasushi Iwasaki; Hiroko Tada; Hidehiko Iwabuki; Marinee K L Chuah; Thierry VandenDriessche; Hideki Fukuda; Akihiko Kondo; Masakazu Ueda; Masaharu Seno; Katsuyuki Tanizawa; Shun'ichi Kuroda
Nanoparticles for the delivery of genes and drugs to human hepatocytes.
Nature biotechnology 2003;21(8):885-90.
2002: Hiromitsu Jinno; Masakazu Ueda; Soji Ozawa; Tadashi Ikeda; Masaki Kitajima; Takashi Maeda; Masaharu Seno
The cytotoxicity of a conjugate composed of human epidermal growth factor and eosinophil cationic protein.
Anticancer research 2002;22(6C):4141-5.
2002: Takashi Maeda; Kazutoshi Mahara; Midori Kitazoe; Junichiro Futami; Aiko Takidani; Megumi Kosaka; Hiroko Tada; Masaharu Seno; Hidenori Yamada
RNase 3 (ECP) is an extraordinarily stable protein among human pancreatic-type RNases.
Journal of biochemistry 2002;132(5):737-42.
2002: Junichiro Futami; Emiko Nukui; Takashi Maeda; Megumi Kosaka; Hiroko Tada; Masaharu Seno; Hidenori Yamada
Optimum modification for the highest cytotoxicity of cationized ribonuclease.
Journal of biochemistry 2002;132(2):223-8.
2002: Kazunori Miura; Hideki Doura; Tomoyasu Aizawa; Hiroko Tada; Masaharu Seno; Hidenori Yamada; Keiichi Kawano
Solution structure of betacellulin, a new member of EGF-family ligands.
Biochemical and biophysical research communications 2002;294(5):1040-6.
2002: Hideto Kojima; Takaaki Nakamura; Yukihiro Fujita; Akio Kishi; Mineko Fujimiya; Syu Yamada; Motoi Kudo; Yoshihiko Nishio; Hiroshi Maegawa; Masakazu Haneda; Hitoshi Yasuda; Itaru Kojima; Masaharu Seno; Norman C W Wong; Ryuichi Kikkawa; Atsunori Kashiwagi
Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin.
Diabetes 2002;51(5):1398-408.
2002: Inés López-Torrejón; Enrique Querol; Francesc X Avilés; Masaharu Seno; Rafael de Llorens; baldomero oliva
Human betacellulin structure modeled from other members of EGF family.
Journal of molecular modeling 2002;8(4):131-44.
2002: Caterina Bianco; Heather B Adkins; Christian Wechselberger; Masaharu Seno; Nicola Normanno; Antonella De Luca; Youping Sun; Nadia Khan; Nicholas Kenney; Andreas Ebert; Kevin P Williams; Michele Sanicola; David S Salomon
Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells.
Molecular and cellular biology 2002;22(8):2586-97.
2002: Caterina Bianco; Nicola Normanno; Antonella De Luca; Monica R Maiello; Christian Wechselberger; Youping Sun; Nadia Khan; Heather B Adkins; Michele Sanicola; Barbara K Vonderhaar; Bruce Cohen; Masaharu Seno; David Salomon
Detection and localization of Cripto-1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin-cripto-1 fusion protein.
Journal of cellular physiology 2002;190(1):74-82.
2002: Takashi Maeda; Midori Kitazoe; Hiroko Tada; Rafael de Llorens; David S Salomon; Masakazu Ueda; Hidenori Yamada; Masaharu Seno
Growth inhibition of mammalian cells by eosinophil cationic protein.
European journal of biochemistry / FEBS 2002;269(1):307-16.
2001: Lei Li; Masaharu Seno; Hidenori Yamada; Itaru Kojima
Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats.
Endocrinology 2001;142(12):5379-85.
2001: Junichiro Futami; Takashi Maeda; Midori Kitazoe; Emiko Nukui; Hiroko Tada; Masaharu Seno; Megumi Kosaka; Hidenori Yamada
Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups.
Biochemistry 2001;40(25):7518-24.
2001: Tadanori Yamada; Hidehiko Iwabuki; T Kanno; H Tanaka; T Kawai; H Fukuda; Akihiko Kondo; Masaharu Seno; Katsuyuki Tanizawa; Shun'ichi Kuroda
Physicochemical and immunological characterization of hepatitis B virus envelope particles exclusively consisting of the entire L (pre-S1 + pre-S2 + S) protein.
Vaccine 2001;19(23-24):3154-63.
2001: joan pous; Goretti Mallorquí-Fernández; Rosa Peracaula; SS Terzyan; Junichiro Futami; H Tada; Hidenori Yamada; Masaharu Seno; Rafael de Llorens; F Xavier Gomis-Rüth; Miquel Coll
Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 4):498-505.
2000: D S Saloman; Caterina Bianco; Andreas Ebert; Nadia I Khan; ML De Santis; Nicola Normanno; Christian Wechselberger; Masaharu Seno; K Williams; Michele Sanicola; S Foley; W J Gullick; G Persico
The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.
Endocrine-related cancer 2000;7(4):199-226.
2000: Junichiro Futami; Hiroko Tada; Masaharu Seno; S Ishikami; Hidenori Yamada
Stabilization of human RNase 1 by introduction of a disulfide bond between residues 4 and 118.
Journal of biochemistry 2000;128(2):245-50.
2000: Goretti Mallorquí-Fernández; joan pous; Rosa Peracaula; Joan Aymamí; T Maeda; H Tada; Hidenori Yamada; Masaharu Seno; Rafael de Llorens; F Xavier Gomis-Rüth; Miquel Coll
Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution.
Journal of molecular biology 2000;300(5):1297-307.
2000: Hiroko Tada; Masaharu Seno; Hidenori Yamada; R Sasada; K Igarashi
Molecular cloning and expression of rat betacellulin cDNA.
Biochimica et biophysica acta 2000;1492(1):285-8.
2000: Kyriakos PSARRAS ; Masakazu Ueda; M Tanabe; Masaki Kitajima; S Aiso; S Komatsu; Masaharu Seno
Targeting activated lymphocytes with an entirely human immunotoxin analogue: human pancreatic RNase1-human IL-2 fusion.
Cytokine 2000;12(6):786-90.
2000: Junichiro Futami; Y Tsushima; Hiroko Tada; Masaharu Seno; Hidenori Yamada
Convenient and efficient in vitro folding of disulfide-containing globular protein from crude bacterial inclusion bodies.
Journal of biochemistry 2000;127(3):435-41.
2000: M L De Santis; I Martinez-Lacaci; C Bianco; Masaharu Seno; Brenda Wallace-Jones; N Kim; Andreas Ebert; Christian Wechselberger; D S Salomon
Cripto-1 induces apoptosis in HC-11 mouse mammary epithelial cells.
Cell death and differentiation 2000;7(2):189-96.
1999: Jun-ichiro Miyagawa; O Hanafusa; R Sasada; Kazuhiro Yamamoto; K Igarashi; Katsumi Yamamori; Masaharu Seno; Hisato Tada; Takao Nammo; Ming Li; Kazuya Yamagata; Hiromu Nakajima; Mitsuyoshi Namba; Masamichi Kuwajima; Yuji Matsuzawa
Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells.
Endocrine journal 1999;46(6):755-64.
1999: Junichiro Futami; Masaharu Seno; Masakazu Ueda; Hiroko Tada; Hidenori Yamada
Inhibition of cell growth by a fused protein of human ribonuclease 1 and human basic fibroblast growth factor.
Protein engineering 1999;12(11):1013-9.
1999: Caterina Bianco; S Kannan; ML De Santis; Masaharu Seno; Careen K Tang; I Martinez-Lacaci; Norma Kim; Brenda Wallace-Jones; Marc Lippman; Andreas Ebert; Christian Wechselberger; David S Salomon
Cripto-1 indirectly stimulates the tyrosine phosphorylation of erb B-4 through a novel receptor.
The Journal of biological chemistry 1999;274(13):8624-9.
1999: Hiroko Tada; R Sasada; Y Kawaguchi; I Kojima; W J Gullick; David S Salomon; K Igarashi; Masaharu Seno; Hidenori Yamada
Processing and juxtacrine activity of membrane-anchored betacellulin.
Journal of cellular biochemistry 1999;72(3):423-34.
1999: H Mashima; Satoko Yamada; T Tajima; Masaharu Seno; Hidenori Yamada; Jun Takeda; Itaru Kojima
Genes expressed during the differentiation of pancreatic AR42J cells into insulin-secreting cells.
Diabetes 1999;48(2):304-9.
1999: SS Terzyan; Rosa Peracaula; Rafael de Llorens; Y Tsushima; Hidenori Yamada; Masaharu Seno; F Xavier Gomis-Rüth; Miquel Coll
The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity.
Journal of molecular biology 1999;285(1):205-14.
1998: Kyriakos PSARRAS ; Masakazu Ueda; T Yamamura; S Ozawa; M Kitajima; S Aiso; S Komatsu; Masaharu Seno
Human pancreatic RNase1-human epidermal growth factor fusion: an entirely human 'immunotoxin analog' with cytotoxic properties against squamous cell carcinomas.
Protein engineering 1998;11(12):1285-92.
1998: N Ishiyama; M Kanzaki; Masaharu Seno; Hidenori Yamada; I Kobayashi; Itaru Kojima
Studies on the betacellulin receptor in pancreatic AR42J cells.
Diabetologia 1998;41(6):623-8.
1998: Masaharu Seno; A Masago; A Nishimura; Hiroko Tada; M Kosaka; R Sasada; K Igarashi; S Seno; Hidenori Yamada
BALB/c 3T3 cells co-expressing FGF-2 and soluble FGF receptor acquire tumorigenicity.
Cytokine 1998;10(4):290-4.
1998: Masaharu Seno; M DeSantis; S Kannan; C Bianco; H Tada; N Kim; M Kosaka; W J Gullick; H Yamada; David S Salomon
Purification and characterization of a recombinant human cripto-1 protein.
Growth factors (Chur, Switzerland) 1998;15(3):215-29.
1997: ML De Santis; S Kannan; Gilbert H Smith; Masaharu Seno; Caterina Bianco; Norma Kim; I Martinez-Lacaci; Brenda Wallace-Jones; David S Salomon
Cripto-1 inhibits beta-casein expression in mammary epithelial cells through a p21ras-and phosphatidylinositol 3'-kinase-dependent pathway.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(12):1257-66.
1997: Junichiro Futami; Y Tsushima; Y Murato; Hiroko Tada; J Sasaki; Masaharu Seno; Hidenori Yamada
Tissue-specific expression of pancreatic-type RNases and RNase inhibitor in humans.
DNA and cell biology 1997;16(4):413-9.
1997: S Kannan; ML De Santis; M Lohmeyer; DJ Riese; Gilbert H Smith; N Hynes; Masaharu Seno; R Brandt; Caterina Bianco; G Persico; Nicholas Kenney; Nicola Normanno; I Martinez-Lacaci; F Ciardiello; David F Stern; W J Gullick; David S Salomon
Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.
The Journal of biological chemistry 1997;272(6):3330-5.
1996: H Mashima; H Ohnishi; K Wakabayashi; Tetsuya Mine; J Miyagawa; T Hanafusa; Masaharu Seno; Hidenori Yamada; Itaru Kojima
Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells.
The Journal of clinical investigation 1996;97(7):1647-54.
1996: Masaharu Seno; Hiroko Tada; M Kosaka; R Sasada; K Igarashi; Yuen Shing; J Folkman; M Ueda; Hidenori Yamada
Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form.
Growth factors (Chur, Switzerland) 1996;13(3-4):181-91.
1996: H Jinno; Masakazu Ueda; Soji Ozawa; T Ikeda; K Enomoto; Kyriakos PSARRAS ; Masaki Kitajima; Hidenori Yamada; Masaharu Seno
Epidermal growth factor receptor-dependent cytotoxicity for human squamous carcinoma cell lines of a conjugate composed of human EGF and RNase 1.
Life sciences 1996;58(21):1901-8.
1995: Junichiro Futami; Masaharu Seno; M Kosaka; Hiroko Tada; S Seno; Hidenori Yamada
Recombinant human pancreatic ribonuclease produced in E. coli: importance of the amino-terminal sequence.
Biochemical and biophysical research communications 1995;216(1):406-13.
1995: Masaharu Seno; Junichiro Futami; Y Tsushima; K Akutagawa; M Kosaka; Hiroko Tada; Hidenori Yamada
Molecular cloning and expression of human ribonuclease 4 cDNA.
Biochimica et biophysica acta 1995;1261(3):424-6.
1994: Hidenori Yamada; Masaharu Seno; A Kobayashi; T Moriyama; M Kosaka; Y Ito; T Imoto
An S-alkylating reagent with positive charges as an efficient solubilizer of denatured disulfide-containing proteins.
Journal of biochemistry 1994;116(4):852-7.
1994: Masaharu Seno; Junichiro Futami; M Kosaka; S Seno; Hidenori Yamada
Nucleotide sequence encoding human pancreatic ribonuclease.
Biochimica et biophysica acta 1994;1218(3):466-8.
1991: M Miyake; M Koyama; Masaharu Seno; S Ikeyama
Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility.
The Journal of experimental medicine 1991;174(6):1347-54.
1991: Masaharu Seno; R Sasada; T Watanabe; K Ishimaru; K Igarashi
Two cDNAs encoding novel human FGF receptor.
Biochimica et biophysica acta 1991;1089(2):244-6.
1991: H Watanabe; A Hori; Masaharu Seno; Y Kozai; K Igarashi; Y Ichimori; K Kondo
A sensitive enzyme immunoassay for human basic fibroblast growth factor.
Biochemical and biophysical research communications 1991;175(1):229-35.
1991: Y Ichimori; Y Kinoshita; T Watanabe; Masaharu Seno; K Kondo
Establishment of monoclonal antibodies against human acidic fibroblast growth factor.
Biochemical and biophysical research communications 1991;175(1):291-7.
1991: R Sasada; Masaharu Seno; T Watanabe; K Igarashi
Expression of modified bFGF cDNAs in mammalian cells.
Annals of the New York Academy of Sciences 1991;638():149-60.
1990: T Watanabe; Masaharu Seno; R Sasada; K Igarashi
Molecular characterization of recombinant human acidic fibroblast growth factor produced in E. coli: comparative studies with human basic fibroblast growth factor.
Molecular endocrinology (Baltimore, Md.) 1990;4(6):869-79.
1990: Masaharu Seno; R Sasada; T Kurokawa; K Igarashi
Carboxyl-terminal structure of basic fibroblast growth factor significantly contributes to its affinity for heparin.
European journal of biochemistry / FEBS 1990;188(2):239-45.
1989: Masaharu Seno; M Iwane; R Sasada; N Moriya; T Kurokawa; K Igarashi
Monoclonal antibodies against human basic fibroblast growth factor.
Hybridoma 1989;8(2):209-21.
1988: Masaharu Seno; R Sasada; M Iwane; K Sudo; T Kurokawa; K Ito; K Igarashi
Stabilizing basic fibroblast growth factor using protein engineering.
Biochemical and biophysical research communications 1988;151(2):701-8.
1987: M Iwane; T Kurokawa; R Sasada; Masaharu Seno; S Nakagawa; K Igarashi
Expression of cDNA encoding human basic fibroblast growth factor in E. coli.
Biochemical and biophysical research communications 1987;146(2):470-7.
1983: T Kurokawa; Masaharu Seno; R Sasada; Y Ono; H Onda; K Igarashi; M Kikuchi; Y Sugino; T Honjo
Expression of human immunoglobulin E epsilon chain cDNA in E. coli.
Nucleic acids research 1983;11(10):3077-85.
1983: Masaharu Seno; T Kurokawa; Y Ono; H Onda; R Sasada; K Igarashi; M Kikuchi; Y Sugino; Y Nishida; T Honjo
Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA.
Nucleic acids research 1983;11(3):719-26.