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Frank carroll

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Hernán A Navarro; James L Howard; Gerald T Pollard; Frank carroll
Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter.
Lance McMahon; Jun-Xu Li; Frank carroll; Charles France
Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys.
Frank carroll
Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction.

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All Publications

2009: Hernán A Navarro; James L Howard; Gerald T Pollard; Frank carroll
Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter.
British journal of pharmacology 2009;156(7):1178-84.
2009: Lance McMahon; Jun-Xu Li; Frank carroll; Charles France
Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys.
Psychopharmacology 2009;203(2):411-20.
2008: Frank carroll
Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction.
Annals of the New York Academy of Sciences 2008;1141():221-32.
2008: Heather L Kimmel; S Stevens Negus; Kristin M Wilcox; Sarah B Ewing; Jeffrey Stehouwer; Mark M Goodman; John R Votaw; Nancy K Mello; Frank carroll; Leonard L Howell
Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys.
Pharmacology, biochemistry, and behavior 2008;90(3):453-62.
2008: Chunyang Jin; Hernán A Navarro; Kevin Page; Frank carroll
Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes.
Bioorganic & medicinal chemistry 2008;16(14):6682-8.
2008: Crystal C Walline; David E Nichols; Frank carroll; Eric L Barker
Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition.
The Journal of pharmacology and experimental therapeutics 2008;325(3):791-800.
2008: Chunyang Jin; Hernán A Navarro; Frank carroll
Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives.
Bioorganic & medicinal chemistry 2008;16(10):5529-35.
2008: Tingwei Bill Cai; Zhou Zou; James B Thomas; Larry Brieaddy; Hernán A Navarro; Frank carroll
Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).
Journal of medicinal chemistry 2008;51(6):1849-60.
2008: William L Woolverton; Zhixia Wang; Theresa Vasterling; Frank carroll; Ronald Tallarida
Self-administration of drug mixtures by monkeys: combining drugs with comparable mechanisms of action.
Psychopharmacology 2008;196(4):575-82.
2008: Emilie D Smith; N Ariane Vinson; Desong Zhong; Bertold D Berrang; Jennifer L Catanzaro; James B Thomas; Hernán A Navarro; Brian P Gilmour; Jeffrey Deschamps; Frank carroll
A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay.
Bioorganic & medicinal chemistry 2008;16(2):822-9.
2008: Bichoy Gabra; Forrest L Smith; Hernán A Navarro; Frank carroll; William L Dewey
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
Brain research 2008;1187():58-66.
2007: Frank carroll; T Philip Robinson; Lawrence E Brieaddy; Robert N Atkinson; Wayne Mascarella; M Imad Damaj; Billy R Martin; Hernán A Navarro
Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.
Journal of medicinal chemistry 2007;50(25):6383-91.
2007: Allison T Knoll; Edward G Meloni; James B Thomas; Frank carroll; William A Carlezon
Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats.
The Journal of pharmacology and experimental therapeutics 2007;323(3):838-45.
2007: Paul K Gong; Bruce E Blough; Lawrence E Brieaddy; Xiaodong Huang; Michael J Kuhar; Hernán A Navarro; Frank carroll
Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.
Journal of medicinal chemistry 2007;50(15):3686-95.
2007: Frank carroll; Sharadsrikar Kotturi; Hernán A Navarro; Wayne Mascarella; Brian P Gilmour; Forrest L Smith; Bichoy Gabra; William L Dewey
Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.
Journal of medicinal chemistry 2007;50(14):3388-91.
2007: Eric Peterson; Melinda G Gunnell; Yingni Che; Robyn L Goforth; Frank carroll; Ralph Henry; Huimin Liu; S Michael Owens
Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse.
The Journal of pharmacology and experimental therapeutics 2007;322(1):30-9.
2007: Leonard L Howell; Frank carroll; John R Votaw; Mark M Goodman; Heather L Kimmel
Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2007;320(2):757-65.
2007: Heather L Kimmel; Joann A O'Connor; Frank carroll; Leonard L Howell
Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys.
Pharmacology, biochemistry, and behavior 2007;86(1):45-54.
2006: Frank carroll; Barbara S Fox; Michael J Kuhar; James L Howard; Gerald T Pollard; Susan Schenk
Effects of dopamine transporter selective 3-phenyltropane analogs on locomotor activity, drug discrimination, and cocaine self-administration after oral administration.
European journal of pharmacology 2006;553(1-3):149-56.
2006: James B Thomas; Li Zhang; Hernán A Navarro; Frank carroll
Highly potent and selective phenylmorphan-based inverse agonists of the opioid delta receptor.
Journal of medicinal chemistry 2006;49(18):5597-609.
2006: Karla B Mihalak; Frank carroll; Charles W Luetje
Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.
Molecular pharmacology 2006;70(3):801-5.
2006: Frank carroll; Bruce E Blough; Xiaodong Huang; Zhe Nie; Wayne Mascarella; Jeffrey Deschamps; Hernán A Navarro
Synthesis and monoamine transporter binding properties of 2,3-cyclo analogues of 3beta-(4'-aminophenyl)-2beta-tropanemethanol.
Journal of medicinal chemistry 2006;49(15):4589-94.
2006: Frank carroll; Xingding Hu; Hernán A Navarro; Jeffrey Deschamps; Galya R Abdrakhmanova; M Imad Damaj; Billy R Martin
Synthesis and pharmacological characterization of nicotinic acetylcholine receptor properties of (+)- and (-)-pyrido-[3,4-b]homotropanes.
Journal of medicinal chemistry 2006;49(11):3244-50.
2006: Galya R Abdrakhmanova; M Imad Damaj; Frank carroll; Billy R Martin
2-Fluoro-3-(4-nitro-phenyl)deschloroepibatidine is a novel potent competitive antagonist of human neuronal alpha4beta2 nAChRs.
Molecular pharmacology 2006;69(6):1945-52.
2006: Jennifer M Kulak; Frank carroll; Jay S Schneider
[125I]Iodomethyllycaconitine binds to alpha7 nicotinic acetylcholine receptors in monkey brain.
The European journal of neuroscience 2006;23(10):2604-10.
2006: Frank carroll; Matt S Melvin; Michel C Nuckols; Wayne Mascarella; Hernán A Navarro; James B Thomas
N-substituted 4beta-methyl-5-(3-hydroxyphenyl)-7alpha-amidomorphans are potent, selective kappa opioid receptor antagonists.
Journal of medicinal chemistry 2006;49(5):1781-91.
2006: Sunmee Wee; Frank carroll; William L Woolverton
A reduced rate of in vivo dopamine transporter binding is associated with lower relative reinforcing efficacy of stimulants.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(2):351-62.
2006: Scott P Runyon; Frank carroll
Dopamine transporter ligands: recent developments and therapeutic potential.
Current topics in medicinal chemistry 2006;6(17):1825-43.
2006: Frank carroll; James L Howard; Leonard L Howell; Barbara S Fox; Michael J Kuhar
Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse.
The AAPS journal 2006;8(1):E196-203.
2005: Frank carroll; Sachin Chaudhari; James B Thomas; Wayne Mascarella; Kenneth M Gigstad; Jeffrey Deschamps; Hernán A Navarro
N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonists.
Journal of medicinal chemistry 2005;48(26):8182-93.
2005: Frank carroll; Lawrence E Brieaddy; Hernán A Navarro; M Imad Damaj; Billy R Martin
Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.
Journal of medicinal chemistry 2005;48(23):7491-5.
2005: Sharadsrikar Kotturi; Songchun Jiang; An-Chih Chang; Philip Abraham; Hernán A Navarro; Michael J Kuhar; Frank carroll
Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes.
Journal of medicinal chemistry 2005;48(23):7437-44.
2005: Frank carroll; Louis S Harris; Mario D Aceto
Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model.
European journal of pharmacology 2005;524(1-3):89-94.
2005: Patrick M Beardsley; James L Howard; Keith L Shelton; Frank carroll
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats.
Psychopharmacology 2005;183(1):118-26.
2005: Kristi S Rau; Elisabeth Birdsall; Jarom E Hanson; Kamisha L Johnson-Davis; Frank carroll; Diana G Wilkins; James W Gibb; Glen R Hanson; Annette E Fleckenstein
Bupropion increases striatal vesicular monoamine transport.
Neuropharmacology 2005;49(6):820-30.
2005: Dalit E Dar; M Thiruvazhi; P Abraham; S Kitayama; Theresa A Kopajtic; A Gamliel; Barbara Slusher; Frank carroll; George R. Uhl
Structure-activity relationship of trihexyphenidyl analogs with respect to the dopamine transporter in the on going search for a cocaine inhibitor.
European journal of medicinal chemistry 2005;40(10):1013-21.
2005: Colin N Haile; Xiang Yang Zhang; Frank carroll; Therese A Kosten
Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter.
Brain research 2005;1055(1-2):186-95.
2005: Frank carroll; Sameer Tyagi; Bruce E Blough; Michael J Kuhar; Hernán A Navarro
Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.
Journal of medicinal chemistry 2005;48(11):3852-7.
2005: Frank carroll; Bruce E Blough; Zhe Nie; Michael J Kuhar; Leonard L Howell; Hernán A Navarro
Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters.
Journal of medicinal chemistry 2005;48(8):2767-71.
2005: Scott P Runyon; Jason P Burgess; Philip Abraham; Kathryn I Keverline-Frantz; Judith L Flippen-Anderson; Jeffrey Deschamps; Anita H Lewin; Hernán A Navarro; John W Boja; Michael J Kuhar; Frank carroll
Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product.
Bioorganic & medicinal chemistry 2005;13(7):2439-49.
2005: Brett Ginsburg; Heather L Kimmel; Frank carroll; Mark M Goodman; Leonard L Howell
Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys.
Pharmacology, biochemistry, and behavior 2005;80(3):481-91.
2005: Frank carroll; Wei Ma; Yasuno Yokota; Jeffrey R Lee; Lawrence E Brieaddy; Hernán A Navarro; M Imad Damaj; Billy R Martin
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists.
Journal of medicinal chemistry 2005;48(4):1221-8.
2004: Frank carroll; Scott P Runyon; Philip Abraham; Hernán A Navarro; Michael J Kuhar; Gerald T Pollard; James L Howard
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
Journal of medicinal chemistry 2004;47(25):6401-9.
2004: M Imad Damaj; Frank carroll; J Brek Eaton; Hernán A Navarro; Bruce E Blough; Sadiq Mirza; Ronald J. Lukas; Billy R Martin
Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors.
Molecular pharmacology 2004;66(3):675-82.
2004: Frank carroll; Roy Ware; Lawrence E Brieaddy; Hernán A Navarro; M Imad Damaj; Billy R Martin
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues. Novel nicotinic antagonist.
Journal of medicinal chemistry 2004;47(18):4588-94.
2004: Donald E McMillan; WC Hardwick; Mi Li; Melinda G Gunnell; Frank carroll; Philip Abraham; S Michael Owens
Effects of murine-derived anti-methamphetamine monoclonal antibodies on (+)-methamphetamine self-administration in the rat.
The Journal of pharmacology and experimental therapeutics 2004;309(3):1248-55.
2004: Kimberly P Lindsey; Kristin M Wilcox; John R Votaw; Mark M Goodman; Christophe Plisson; Frank carroll; Kenner C Rice; Leonard L Howell
Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging.
The Journal of pharmacology and experimental therapeutics 2004;309(3):959-69.
2004: Frank carroll
Epibatidine structure-activity relationships.
Bioorganic & medicinal chemistry letters 2004;14(8):1889-96.
2004: Shridhar Narayanan; Hoa Lam; Frank carroll; Kabirullah Lutfy
Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats.
Journal of psychiatry & neuroscience : JPN 2004;29(2):116-23.
2004: James B Thomas; Scott E Fix; Richard B Rothman; Wayne Mascarella; Christina M Dersch; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Importance of phenolic address groups in opioid kappa receptor selective antagonists.
Journal of medicinal chemistry 2004;47(4):1070-3.
2004: David Roman; Shannon N Saldaña; David E Nichols; Frank carroll; Eric L Barker
Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters.
The Journal of pharmacology and experimental therapeutics 2004;308(2):679-87.
2004: Frank carroll; Neil Pawlush; Michael J Kuhar; Gerald T Pollard; James L Howard
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.
Journal of medicinal chemistry 2004;47(2):296-302.
2004: Frank carroll; Li Zhang; Wayne Mascarella; Hernán A Navarro; Richard B Rothman; Buddy E Cantrell; Dennis M Zimmerman; James B Thomas
Discovery of the first N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid delta receptor antagonist activity.
Journal of medicinal chemistry 2004;47(2):281-4.
2003: Kabirullah Lutfy; Shoshana Eitan; Camron D Bryant; Yu C Yang; Nazli Saliminejad; Wendy Walwyn; Jerome Becker; Hiroshi Takeshima; Frank carroll; Nigel T Maidment; Christopher J Evans
Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(32):10331-7.
2003: Søren G F Rasmussen; Erika Adkins Scholl; Frank carroll; Martin J Maresch; Ulrik Gether
Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy.
European journal of pharmacology 2003;479(1-3):13-22.
2003: James B Thomas; Robert N Atkinson; N Ariane Vinson; Jennifer L Catanzaro; Carin L Perretta; Scott E Fix; Wayne Mascarella; Richard B Rothman; Heng Xu; Christina M Dersch; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.
Journal of medicinal chemistry 2003;46(14):3127-37.
2003: George P Hess; Armanda Gameiro; Ryan C Schoenfeld; Yongli Chen; Henning Ulrich; Jeffrey A Nye; Barbara Sit; Frank carroll; Bruce Ganem
Reversing the action of noncompetitive inhibitors (MK-801 and cocaine) on a protein (nicotinic acetylcholine receptor)-mediated reaction.
Biochemistry 2003;42(20):6106-14.
2003: Frank carroll
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Journal of medicinal chemistry 2003;46(10):1775-94.
2003: Kelly A Byrnes-Blake; Elizabeth M Laurenzana; Frank carroll; Philip Abraham; W Brooks Gentry; Reid D Landes; S Michael Owens
Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats.
European journal of pharmacology 2003;461(2-3):119-28.
2003: Heather L Kimmel; Frank carroll; Michael J Kuhar
Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum.
The Journal of pharmacology and experimental therapeutics 2003;304(1):15-21.
2002: Kabirullah Lutfy; Imran Khaliq; Frank carroll; Nigel T Maidment
Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats.
Psychopharmacology 2002;164(2):168-76.
2002: Frank carroll; Jeffrey R Lee; Hernán A Navarro; Wei Ma; Lawrence E Brieaddy; Philip Abraham; M Imad Damaj; Billy R Martin
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2',3'-disubstituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes: epibatidine analogues.
Journal of medicinal chemistry 2002;45(21):4755-61.
2002: Melva Avalos; Michael J Parker; Floyd N Maddox; Frank carroll; Charles W Luetje
Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1246-52.
2002: Stephanie L Collins; Paul M Kunko; Bruce Ladenheim; Jean Lud Cadet; Frank carroll; Sari Izenwasser
Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors.
Synapse (New York, N.Y.) 2002;45(3):153-8.
2002: Bruce E Blough; Kathryn I Keverline; Zhe Nie; Hernán A Navarro; Michael J Kuhar; Frank carroll
Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.
Journal of medicinal chemistry 2002;45(18):4029-37.
2002: James B Thomas; Robert N Atkinson; Nivedita Namdev; Richard B Rothman; Kenneth M Gigstad; Scott E Fix; Wayne Mascarella; Jason P Burgess; N Ariane Vinson; Heng Xu; Christina M Dersch; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.
Journal of medicinal chemistry 2002;45(16):3524-30.
2002: Qun Wu; Maarten E A Reith; Q David Walker; Cynthia M Kuhn; Frank carroll; Paul Garris
Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(14):6272-81.
2002: Hernán A Navarro; H Xu; D Zhong; P Abraham; Frank carroll
In vitro and in vivo characterization of [125I]iodomethyllycaconitine in the rat.
Synapse (New York, N.Y.) 2002;44(3):117-23.
2002: charlie cook; Frank carroll; Patrick M Beardsley
RTI 113, a 3-phenyltropane analog, produces long-lasting cocaine-like discriminative stimulus effects in rats and squirrel monkeys.
European journal of pharmacology 2002;442(1-2):93-8.
2002: Richard B Rothman; Frank carroll; Marisela Morales; Daniel L Rowley; Kenner C Rice; Christina M Dersch; David M Donovan
Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice.
Synapse (New York, N.Y.) 2002;44(2):94-105.
2002: Richard B Rothman; Christina M Dersch; Frank carroll; Subramaniam Ananthan
Studies of the biogenic amine transporters. VIII: identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding.
Synapse (New York, N.Y.) 2002;43(4):268-74.
2002: Kristin M Wilcox; Kimberly P Lindsey; John R Votaw; Mark M Goodman; Laurent Martarello; Frank carroll; Leonard L Howell
Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys.
Synapse (New York, N.Y.) 2002;43(1):78-85.
2001: Heather L Kimmel; Frank carroll; Michael J Kuhar
Locomotor stimulant effects of novel phenyltropanes in the mouse.
Drug and alcohol dependence 2001;65(1):25-36.
2001: Frank carroll; Jeffrey R Lee; Hernán A Navarro; Lawrence E Brieaddy; Philip Abraham; M Imad Damaj; Billy R Martin
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted-3'-phenyl-5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel nicotinic antagonist.
Journal of medicinal chemistry 2001;44(24):4039-41.
2001: PA Zaki; Duane Keith; J B Thomas; Frank carroll; Christopher J Evans
Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation.
The Journal of pharmacology and experimental therapeutics 2001;298(3):1015-20.
2001: Hernán A Navarro; H Xu; D Zhong; Bruce E Blough; W P Ross; Michael J Kuhar; Frank carroll
[(125)I]3beta-(4-ethyl-3-iodophenyl)nortropane-2beta-carboxylic acid methyl ester ([(125)I]EINT): a potent and selective radioligand for the brain serotonin transporter.
Synapse (New York, N.Y.) 2001;41(3):241-7.
2001: James B Thomas; Robert N Atkinson; Richard B Rothman; Scott E Fix; Wayne Mascarella; N Ariane Vinson; Heng Xu; Christina M Dersch; Y Lu; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.
Journal of medicinal chemistry 2001;44(17):2687-90.
2001: Qun Wu; Maarten E A Reith; Michael J Kuhar; Frank carroll; Paul Garris
Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(16):6338-47.
2001: Michael J Kuhar; Frank carroll; Narine Bharat; Donald W Landry
Anticocaine catalytic antibodies have no affinity for RTI compounds: implications for treatment.
Synapse (New York, N.Y.) 2001;41(2):176-8.
2001: Heather L Kimmel; AR Joyce; Frank carroll; Michael J Kuhar
Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat.
The Journal of pharmacology and experimental therapeutics 2001;298(1):129-40.
2001: Frank carroll; F Liang; Hernán A Navarro; Lawrence E Brieaddy; Philip Abraham; M Imad Damaj; Billy R Martin
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues.
Journal of medicinal chemistry 2001;44(13):2229-37.
2001: Heng Xu; Yi-Feng Lu; J B Thomas; Frank carroll; Kenner C Rice; Richard B Rothman
Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor.
Synapse (New York, N.Y.) 2001;40(4):269-74.
2001: Heather L Kimmel; Frank carroll; Michael J Kuhar
RTI-76, an irreversible inhibitor of dopamine transporter binding, increases locomotor activity in the rat at high doses.
Brain research 2001;897(1-2):157-63.
2001: James B Thomas; XM Herault; Richard B Rothman; Robert N Atkinson; Jason P Burgess; Wayne Mascarella; Christina M Dersch; Heng Xu; Judith L Flippen-Anderson; CF George; Frank carroll
Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.
Journal of medicinal chemistry 2001;44(6):972-87.
2001: Søren G F Rasmussen; Frank carroll; M J Maresch; Anne D Jensen; C G Tate; Ulrik Gether
Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter.
The Journal of biological chemistry 2001;276(7):4717-23.
2001: Kelly A Byrnes-Blake; Frank carroll; Philip Abraham; S Michael Owens
Generation of anti-(+)methamphetamine antibodies is not impeded by (+)methamphetamine administration during active immunization of rats.
International immunopharmacology 2001;1(2):329-38.
2001: Heng Xu; A Hashimoto; Kenner C Rice; Arthur E Jacobson; J B Thomas; Frank carroll; J Lai; Richard B Rothman
Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay.
Synapse (New York, N.Y.) 2001;39(1):64-9.
2001: Richard B Rothman; Michael H Baumann; Christina M Dersch; D V Romero; Kenner C Rice; Frank carroll; John S Partilla
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.
Synapse (New York, N.Y.) 2001;39(1):32-41.
2000: Robert Ranaldi; Karen G Anderson; Frank carroll; William L Woolverton
Reinforcing and discriminative stimulus effects of RTI 111, a 3-phenyltropane analog, in rhesus monkeys: interaction with methamphetamine.
Psychopharmacology 2000;153(1):103-10.
2000: Bruce E Blough; C R Holmquist; Philip Abraham; Michael J Kuhar; Frank carroll
3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.
Bioorganic & medicinal chemistry letters 2000;10(21):2445-7.
2000: Richard B Rothman; John S Partilla; Christina M Dersch; Frank carroll; Kenner C Rice; Michael H Baumann
Methamphetamine dependence: medication development efforts based on the dual deficit model of stimulant addiction.
Annals of the New York Academy of Sciences 2000;914():71-81.
2000: James B Thomas; Robert N Atkinson; Richard B Rothman; Jason P Burgess; Wayne Mascarella; Christina M Dersch; Heng Xu; Frank carroll
4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.
Bioorganic & medicinal chemistry letters 2000;10(11):1281-4.
2000: PA Zaki; Duane Keith; G A Brine; Frank carroll; Christopher J Evans
Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation?
The Journal of pharmacology and experimental therapeutics 2000;292(3):1127-34.
2000: Richard B Rothman; John S Partilla; Michael H Baumann; Christina M Dersch; Frank carroll; Kenner C Rice
Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse.
Synapse (New York, N.Y.) 2000;35(3):222-7.
2000: Heather L Kimmel; Frank carroll; Michael J Kuhar
Dopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76.
Neuropharmacology 2000;39(4):578-85.
1999: James B Thomas; Robert N Atkinson; XM Herault; Richard B Rothman; Wayne Mascarella; Christina M Dersch; Heng Xu; Robert Horel; Frank carroll
Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.
Bioorganic & medicinal chemistry letters 1999;9(23):3347-50.
1999: Frank carroll; X Bai; A Dehghani; Wayne Mascarella; Wanda Williams; W D Bowen
Asymmetric synthesis of 9-alkyl-2-benzyl-6,7-benzomorphans: characterization as novel sigma receptor ligands.
Journal of medicinal chemistry 1999;42(22):4621-9.
1999: James B Thomas; XM Herault; Richard B Rothman; Jason P Burgess; Wayne Mascarella; Heng Xu; Robert Horel; Christina M Dersch; Frank carroll
(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.
Bioorganic & medicinal chemistry letters 1999;9(20):3053-6.
1999: Michael J Kuhar; KM McGirr; Richard Hunter; PD Lambert; B E Garrett; Frank carroll
Studies of selected phenyltropanes at monoamine transporters.
Drug and alcohol dependence 1999;56(1):9-15.
1999: Frank carroll; Leonard L Howell; Michael J Kuhar
Pharmacotherapies for treatment of cocaine abuse: preclinical aspects.
Journal of medicinal chemistry 1999;42(15):2721-36.
1999: M Imad Damaj; JE Slemmer; Frank carroll; Billy R Martin
Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.
The Journal of pharmacology and experimental therapeutics 1999;289(3):1229-36.
1999: Heng Xu; Yi-Feng Lu; John S Partilla; Q X Zheng; Jia Bei Wang; G A Brine; Frank carroll; Kenner C Rice; Kai-Xian Chen; Zhi-Qiang Chi; Richard B Rothman
Opioid peptide receptor studies, 11: involvement of Tyr148, Trp318 and His319 of the rat mu-opioid receptor in binding of mu-selective ligands.
Synapse (New York, N.Y.) 1999;32(1):23-8.
1999: Sari Izenwasser; Dawn French; Frank carroll; Paul M Kunko
Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity.
Behavioural brain research 1999;99(2):201-8.
1998: James B Thomas; M J Fall; J B Cooper; Richard B Rothman; Wayne Mascarella; Heng Xu; John S Partilla; Christina M Dersch; KB McCullough; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.
Journal of medicinal chemistry 1998;41(26):5188-97.
1998: S Jiang; A C Chang; Philip Abraham; Michael J Kuhar; Frank carroll
Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes.
Bioorganic & medicinal chemistry letters 1998;8(24):3689-92.
1998: James B Thomas; Wayne Mascarella; Jason P Burgess; Heng Xu; KB McCullough; Richard B Rothman; Judith L Flippen-Anderson; CF George; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.
Bioorganic & medicinal chemistry letters 1998;8(22):3149-52.
1998: James B Thomas; X Zheng; Wayne Mascarella; Richard B Rothman; Christina M Dersch; John S Partilla; Judith L Flippen-Anderson; CF George; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.
Journal of medicinal chemistry 1998;41(21):4143-9.
1998: J W Boja; Frank carroll; R A Vaughan; Theresa A Kopajtic; Michael J Kuhar
Multiple binding sites for [125I]RTI-121 and other cocaine analogs in rat frontal cerebral cortex.
Synapse (New York, N.Y.) 1998;30(1):9-17.
1998: James B Thomas; Wayne Mascarella; Richard B Rothman; John S Partilla; Heng Xu; KB McCullough; Christina M Dersch; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.
Journal of medicinal chemistry 1998;41(11):1980-90.
1998: Richard B Rothman; M L Silverthorn; John R Glowa; Dorota Matecka; Kenner C Rice; Frank carroll; John S Partilla; George R. Uhl; David J Vandenbergh; Christina M Dersch
Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate.
Synapse (New York, N.Y.) 1998;28(4):322-38.
1998: Yi-Feng Lu; Heng Xu; L Y Liu-Chen; C Chen; John S Partilla; G A Brine; Frank carroll; Kenner C Rice; J Lai; Frank Porreca; W Sadee; Richard B Rothman
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Synapse (New York, N.Y.) 1998;28(2):117-24.
1998: K I Keverline-Frantz; John W Boja; Michael J Kuhar; Philip Abraham; Jason P Burgess; Anita H Lewin; Frank carroll
Synthesis and ligand binding of tropane ring analogues of paroxetine.
Journal of medicinal chemistry 1998;41(2):247-57.
1997: B E Blough; Philip Abraham; A C Mills; Anita H Lewin; John W Boja; U Scheffel; Michael J Kuhar; Frank carroll
3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter.
Journal of medicinal chemistry 1997;40(24):3861-4.
1997: F Liang; H A Navarro; Philip Abraham; P Kotian; Y S Ding; Joanna S Fowler; Nora D Volkow; Michael J Kuhar; Frank carroll
Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2'-fluoro-5'-pyridinyl)-7-azabicyclo-[2.2.1]heptane: a new positron emission tomography ligand for nicotinic receptors.
Journal of medicinal chemistry 1997;40(15):2293-5.
1997: A C Chang; Jason P Burgess; Wayne Mascarella; Philip Abraham; Michael J Kuhar; Frank carroll
Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.
Journal of medicinal chemistry 1997;40(8):1247-51.
1996: C R Holmquist; K I Keverline-Frantz; Philip Abraham; J W Boja; Michael J Kuhar; Frank carroll
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
Journal of medicinal chemistry 1996;39(21):4139-41.
1996: A E Fleckenstein; S Pögün; Frank carroll; Michael J Kuhar
Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 [3 beta-(3p-chlorophenyl) tropan-2 beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride].
The Journal of pharmacology and experimental therapeutics 1996;279(1):200-6.
1996: B E Blough; Philip Abraham; Anita H Lewin; Michael J Kuhar; J W Boja; Frank carroll
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.
Journal of medicinal chemistry 1996;39(20):4027-35.
1996: A E Fleckenstein; Theresa A Kopajtic; J W Boja; Frank carroll; Michael J Kuhar
Highly potent cocaine analogs cause long-lasting increases in locomotor activity.
European journal of pharmacology 1996;311(2-3):109-14.
1996: C W Sachs; L M Ballas; Wayne Mascarella; A R Safa; Anita H Lewin; C Loomis; Frank carroll; R M Bell; R L Fine
Effects of sphingosine stereoisomers on P-glycoprotein phosphorylation and vinblastine accumulation in multidrug-resistant MCF-7 cells.
Biochemical pharmacology 1996;52(4):603-12.
1996: P Kotian; Wayne Mascarella; Philip Abraham; Anita H Lewin; J W Boja; Michael J Kuhar; Frank carroll
Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.
Journal of medicinal chemistry 1996;39(14):2753-63.
1996: John R Lever; Ursula Scheffel; M Stathis; Herbert H Seltzman; C D Wyrick; Philip Abraham; K Parham; Brian Thomas; J W Boja; Michael J Kuhar; Frank carroll
Synthesis and in vivo studies of a selective ligand for the dopamine transporter: 3 beta-(4-[125I]iodophenyl) tropan-2 beta-carboxylic acid isopropyl ester ([125I]RTI-121).
Nuclear medicine and biology 1996;23(3):277-84.
1996: John L Musachio; K I Keverline; Frank carroll; Robert F Dannals
3 Beta-(p-trimethylsilylphenyl)tropane-2 beta-carboxylic acid methyl ester: a new precursor for the preparation of [123I]RTI-55.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1996;47(1):79-81.
1995: Ursula Scheffel; G F Taylor; J A Kepler; Frank carroll; Michael J Kuhar
In vivo labeling of neuronal nicotinic acetylcholine receptors with radiolabeled isomers of norchloroepibatidine.
Neuroreport 1995;6(18):2483-8.
1995: J K Staley; J W Boja; Frank carroll; Herbert H Seltzman; C D Wyrick; Anita H Lewin; Philip Abraham; Deborah C Mash
Mapping dopamine transporters in the human brain with novel selective cocaine analog [125I]RTI-121.
Synapse (New York, N.Y.) 1995;21(4):364-72.
1995: Frank carroll; U Scheffel; Robert F Dannals; J W Boja; Michael J Kuhar
Development of imaging agents for the dopamine transporter.
Medicinal research reviews 1995;15(5):419-44.
1995: P Kotian; Philip Abraham; Anita H Lewin; Wayne Mascarella; J W Boja; Michael J Kuhar; Frank carroll
Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.
Journal of medicinal chemistry 1995;38(18):3451-3.
1995: R Danso-Danquah; X Bai; X Zhang; Wayne Mascarella; Wanda Williams; B Sine; Wayne D Bowen; Frank carroll
Synthesis and sigma binding properties of 1'- and 3'-halo- and 1',3'-dihalo-N-normetazocine analogues.
Journal of medicinal chemistry 1995;38(15):2986-9.
1995: R Danso-Danquah; X Bai; X Zhang; Wayne Mascarella; Wanda Williams; B Sine; Wayne D Bowen; Frank carroll
Synthesis and sigma binding properties of 2'-substituted 5,9 alpha-dimethyl-6,7-benzomorphans.
Journal of medicinal chemistry 1995;38(15):2978-85.
1995: Richard B Rothman; M L Silverthorn; Michael H Baumann; Carl B Goodman; Jean Lud Cadet; Dorota Matecka; Kenner C Rice; Frank carroll; Jia Bei Wang; George R. Uhl
Studies of the biogenic amine transporters. VI. Characterization of a novel cocaine binding site, identified with [125I]RTI-55, in membranes prepared from whole rat brain minus caudate.
The Journal of pharmacology and experimental therapeutics 1995;274(1):385-95.
1995: Anita H Lewin; S L Black; M E Bos; R R Goehring; X Nair; G Whiting; P Bouquin; G Tetrault; Frank carroll
Evaluation of retinoid lactones as topical therapeutic agents in dermatology.
Pharmaceutical research 1995;12(7):983-92.
1995: M Stathis; Ursula Scheffel; SZ Lever; J W Boja; Frank carroll; Michael J Kuhar
Rate of binding of various inhibitors at the dopamine transporter in vivo.
Psychopharmacology 1995;119(4):376-84.
1995: G A Brine; P A Stark; Y Liu; Frank carroll; P Singh; H Xu; Richard B Rothman
Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.
Journal of medicinal chemistry 1995;38(9):1547-57.
1995: J W Boja; Jean Lud Cadet; Theresa A Kopajtic; John R Lever; Herbert H Seltzman; C D Wyrick; Anita H Lewin; Philip Abraham; Frank carroll
Selective labeling of the dopamine transporter by the high affinity ligand 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester.
Molecular pharmacology 1995;47(4):779-86.
1995: M L Silverthorn; Christina M Dersch; Michael H Baumann; Jean Lud Cadet; John S Partilla; Kenner C Rice; Frank carroll; K M Becketts; A Brockington; Richard B Rothman
Studies of the biogenic amine transporters. V. Demonstration of two binding sites for the cocaine analog [125I]RTI-55 associated with the 5-HT transporter in rat brain membranes.
The Journal of pharmacology and experimental therapeutics 1995;273(1):213-22.
1995: S D Weiser; S L Patrick; Wayne Mascarella; J Downing-Park; X Bai; Frank carroll; J Michael Walker; R L Patrick
Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of sigma receptor ligands.
European journal of pharmacology 1995;275(1):1-7.
1995: Wayne Mascarella; X Bai; Wanda Williams; B Sine; Wayne D Bowen; Frank carroll
(+)-cis-N-(para-, meta-, and ortho-substituted benzyl)-N-normetazocines: synthesis and binding affinity at the [3H]-(+)-pentazocine-labeled (sigma 1) site and quantitative structure-affinity relationship studies.
Journal of medicinal chemistry 1995;38(3):565-9.
1995: Frank carroll; P Kotian; A Dehghani; J L Gray; M A Kuzemko; K A Parham; Philip Abraham; Anita H Lewin; J W Boja; Michael J Kuhar
Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.
Journal of medicinal chemistry 1995;38(2):379-88.
1994: Frank carroll; Wayne Mascarella; M A Kuzemko; Y Gao; Philip Abraham; Anita H Lewin; J W Boja; Michael J Kuhar
Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters.
Journal of medicinal chemistry 1994;37(18):2865-73.
1994: Richard B Rothman; Jean Lud Cadet; H C Akunne; M L Silverthorn; Michael H Baumann; Frank carroll; Kenner C Rice; B R de Costa; John S Partilla; Jia Bei Wang
Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate membranes for the cocaine analog [125I]RTI-55.
The Journal of pharmacology and experimental therapeutics 1994;270(1):296-309.
1994: Anita H Lewin; R R Goehring; F C Zusi; G J Gendimenico; X Nair; G Whitting; P Bouquin; G Tetrault; Frank carroll
The requirement for a retinoic acid lactone of 11-cis, 13-cis-stereochemistry for topical dermatologic activity.
Pharmaceutical research 1994;11(7):1065-7.
1994: J W Boja; Michael J Kuhar; Theresa A Kopajtic; Emily Boja; Philip Abraham; Anita H Lewin; Frank carroll
Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.
Journal of medicinal chemistry 1994;37(8):1220-3.
1994: H C Akunne; Christina M Dersch; Jean Lud Cadet; Michael H Baumann; G U Char; John S Partilla; B R de Costa; Kenner C Rice; Frank carroll; Richard B Rothman
Studies of the biogenic amine transporters. III. Demonstration of two binding sites for [3H]GBR12935 and [3H]BTCP in rat caudate membranes.
The Journal of pharmacology and experimental therapeutics 1994;268(3):1462-75.
1994: Christina M Dersch; H C Akunne; John S Partilla; G U Char; B R de Costa; Kenner C Rice; Frank carroll; Richard B Rothman
Studies of the biogenic amine transporters. 1. Dopamine reuptake blockers inhibit [3H]mazindol binding to the dopamine transporter by a competitive mechanism: preliminary evidence for different binding domains.
Neurochemical research 1994;19(2):201-8.
1994: Anita H Lewin; M E Bos; F C Zusi; X Nair; G Whiting; P Bouquin; G Tetrault; Frank carroll
Evaluation of retinoids as therapeutic agents in dermatology.
Pharmaceutical research 1994;11(2):192-200.
1994: Carl B Goodman; D N Thomas; A Pert; B Emilien; Jean Lud Cadet; Frank carroll; B E Blough; Wayne Mascarella; Michael A Rogawski; S Subramaniam
RTI-4793-14, a new ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brain.
Synapse (New York, N.Y.) 1994;16(1):59-65.
1994: U Scheffel; Robert F Dannals; M Suehiro; George A Ricaurte; Frank carroll; Michael J Kuhar; Henry N Wagner
Development of PET/SPECT ligands for the serotonin transporter.
NIDA research monograph 1994;138():111-30.
1993: Q Ni; Heng Xu; John S Partilla; P A Stark; Frank carroll; G A Brine; Richard B Rothman
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains.
Synapse (New York, N.Y.) 1993;15(4):296-306.
1993: Frank carroll; J L Gray; Philip Abraham; M A Kuzemko; Anita H Lewin; J W Boja; Michael J Kuhar
3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters.
Journal of medicinal chemistry 1993;36(20):2886-90.
1993: J Michael Walker; Wayne D Bowen; S L Patrick; Wanda Williams; Wayne Mascarella; X Bai; Frank carroll
A comparison of (-)-deoxybenzomorphans devoid of opiate activity with their dextrorotatory phenolic counterparts suggests role of sigma 2 receptors in motor function.
European journal of pharmacology 1993;231(1):61-8.
1993: Richard B Rothman; K M Becketts; L R Radesca; B R de Costa; Kenner C Rice; Frank carroll; Christina M Dersch
Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists.
Life sciences 1993;53(17):PL267-72.
1993: Frank carroll; Anita H Lewin; Michael J Kuhar; J W Boja
Cocaine receptor: a structure-activity relationship study.
NIDA research monograph 1993;134():229-37.
1992: Richard B Rothman; N Grieg; A Kim; B R De Costa; Kenner C Rice; Frank carroll; A Pert
Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter.
Pharmacology, biochemistry, and behavior 1992;43(4):1135-42.
1992: J W Boja; R M McNeill; Anita H Lewin; Philip Abraham; Frank carroll; Michael J Kuhar
Selective dopamine transporter inhibition by cocaine analogs.
Neuroreport 1992;3(11):984-6.
1992: Ursula Scheffel; Robert F Dannals; Dean F Wong; Fuji Yokoi; Frank carroll; Michael J Kuhar
Dopamine transporter imaging with novel, selective cocaine analogs.
Neuroreport 1992;3(11):969-72.
1992: E J Cline; Ursula Scheffel; J W Boja; W M Mitchell; Frank carroll; Philip Abraham; Anita H Lewin; Michael J Kuhar
In vivo binding of [125I]RTI-55 to dopamine transporters: pharmacology and regional distribution with autoradiography.
Synapse (New York, N.Y.) 1992;12(1):37-46.
1992: J W Boja; W M Mitchell; A Patel; Theresa A Kopajtic; Frank carroll; Anita H Lewin; Philip Abraham; Michael J Kuhar
High-affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain.
Synapse (New York, N.Y.) 1992;12(1):27-36.
1992: Frank carroll; Philip Abraham; K Parham; X Bai; X Zhang; G A Brine; Wayne Mascarella; B R Martin; Everette L May; C Sauss
Enantiomeric N-substituted N-normetazocines: a comparative study of affinities at sigma, PCP, and mu opioid receptors.
Journal of medicinal chemistry 1992;35(15):2812-8.
1992: J W Boja; E J Cline; Frank carroll; Anita H Lewin; A Philip; Robert F Dannals; Dean F Wong; Ursula Scheffel; Michael J Kuhar
High potency cocaine analogs: neurochemical, imaging, and behavioral studies.
Annals of the New York Academy of Sciences 1992;654():282-91.
1992: Frank carroll; Philip Abraham; Anita H Lewin; K A Parham; J W Boja; Michael J Kuhar
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
Journal of medicinal chemistry 1992;35(13):2497-500.
1992: Frank carroll; Philip Abraham; S Chemburkar; X C He; Wayne Mascarella; Y W Kwon; D J Triggle
Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol.
Journal of medicinal chemistry 1992;35(12):2184-91.
1992: Ursula Scheffel; Robert F Dannals; E J Cline; George A Ricaurte; Frank carroll; Philip Abraham; Anita H Lewin; Michael J Kuhar
[123/125I]RTI-55, an in vivo label for the serotonin transporter.
Synapse (New York, N.Y.) 1992;11(2):134-9.
1992: Frank carroll; Y Gao; Philip Abraham; Anita H Lewin; R Lew; A Patel; J W Boja; Michael J Kuhar
Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter.
Journal of medicinal chemistry 1992;35(10):1813-7.
1992: A Patel; J W Boja; John R Lever; R Lew; R Simantov; Frank carroll; Anita H Lewin; A Philip; Y Gao; Michael J Kuhar
A cocaine analog and a GBR analog label the same protein in rat striatal membranes.
Brain research 1992;576(1):173-4.
1992: Frank carroll; Anita H Lewin; J W Boja; Michael J Kuhar
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Journal of medicinal chemistry 1992;35(6):969-81.
1992: E J Cline; Ursula Scheffel; J W Boja; Frank carroll; Jonathan L Katz; Michael J Kuhar
Behavioral effects of novel cocaine analogs: a comparison with in vivo receptor binding potency.
The Journal of pharmacology and experimental therapeutics 1992;260(3):1174-9.
1992: ELIAS SHAYA; Ursula Scheffel; Robert F Dannals; George A Ricaurte; Frank carroll; Henry N Wagner; Michael J Kuhar; Dean F Wong
In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine-123 labeled RTI-55.
Synapse (New York, N.Y.) 1992;10(2):169-72.
1992: Philip Abraham; J B Pitner; Anita H Lewin; J W Boja; Michael J Kuhar; Frank carroll
N-modified analogues of cocaine: synthesis and inhibition of binding to the cocaine receptor.
Journal of medicinal chemistry 1992;35(1):141-4.
1992: Anita H Lewin; Y G Gao; Philip Abraham; J W Boja; Michael J Kuhar; Frank carroll
2 beta-substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor.
Journal of medicinal chemistry 1992;35(1):135-40.
1991: Robert L Balster; Frank carroll; J H Graham; R S Mansbach; M A Rahman; A Philip; Anita H Lewin; V M Showalter
Potent substituted-3 beta-phenyltropane analogs of cocaine have cocaine-like discriminative stimulus effects.
Drug and alcohol dependence 1991;29(2):145-51.
1991: D J Triggle; Y W Kwon; Philip Abraham; J B Pitner; Wayne Mascarella; Frank carroll
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Journal of medicinal chemistry 1991;34(11):3164-71.
1991: W A Khan; Wayne Mascarella; Anita H Lewin; C D Wyrick; Frank carroll; Yusuf A Hannun
Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets.
The Biochemical journal 1991;278 ( Pt 2)():387-92.
1991: Frank carroll; Y G Gao; M A Rahman; Philip Abraham; K Parham; Anita H Lewin; J W Boja; Michael J Kuhar
Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters.
Journal of medicinal chemistry 1991;34(9):2719-25.
1991: John J Woodward; R Mansbach; Frank carroll; Robert L Balster
Cocaethylene inhibits dopamine uptake and produces cocaine-like actions in drug discrimination studies.
European journal of pharmacology 1991;197(2-3):235-6.
1991: Frank carroll; Philip Abraham; Wayne Mascarella; P Singh; C G Moreland; S S Sankar; Y W Kwon; D J Triggle
Crystal, solution, and molecular modeling structural properties and muscarinic antagonist activity of azaprophen.
Journal of medicinal chemistry 1991;34(4):1436-40.
1991: Frank carroll; Anita H Lewin; Philip Abraham; K Parham; J W Boja; Michael J Kuhar
Synthesis and ligand binding of cocaine isomers at the cocaine receptor.
Journal of medicinal chemistry 1991;34(3):883-6.
1991: J W Boja; M A Rahman; A Philip; Anita H Lewin; Frank carroll; Michael J Kuhar
Isothiocyanate derivatives of cocaine: irreversible inhibition of ligand binding at the dopamine transporter.
Molecular pharmacology 1991;39(3):339-45.
1991: J W Boja; A Patel; Frank carroll; M A Rahman; A Philip; Anita H Lewin; Theresa A Kopajtic; Michael J Kuhar
[125I]RTI-55: a potent ligand for dopamine transporters.
European journal of pharmacology 1991;194(1):133-4.
1991: X Nair; J Quigley; KM Tramposch; Frank carroll; Anita H Lewin; I Kiss
BMY 30047: a novel topically active retinoid with low local and systemic toxicity.
The Journal of pharmacology and experimental therapeutics 1991;256(1):365-70.
1991: Frank carroll; Anita H Lewin
Important compounds in the cocaine class: a synthesis overview.
NIDA research monograph 1991;112():284-99.
1990: M C Ritz; J W Boja; D Grigoriadis; Robert Zaczek; Frank carroll; A H Lewis; Michael J Kuhar
[3H]WIN 35,065-2: a ligand for cocaine receptors in striatum.
Journal of neurochemistry 1990;55(5):1556-62.
1990: Frank carroll; M B Gopinathan; A Philip
S-[2-[(2'-carbamoylethyl)amino]ethyl] phosphorothioate and related compounds as potential antiradiation agents.
Journal of medicinal chemistry 1990;33(9):2501-8.
1990: J W Boja; Frank carroll; M A Rahman; A Philip; Anita H Lewin; Michael J Kuhar
New, potent cocaine analogs: ligand binding and transport studies in rat striatum.
European journal of pharmacology 1990;184(2-3):329-32.
1990: Frank carroll; A Philip; Anita H Lewin
Cocaine receptor--design of ligands.
NIDA research monograph 1990;96():112-21.
1990: Frank carroll; M A Rahman; A Philip; Anita H Lewin; J W Boja; Michael J Kuhar
Synthesis and receptor binding of cocaine analogs.
NIDA research monograph 1990;105():147-53.
1989: Frank carroll; K G Boldt; P T Huang; D K Sawyer; G A Brine
Synthesis of fentanyl analogs.
NIDA research monograph 1989;95():497-8.
1988: A Thurkauf; P C Zenk; R L Balster; Everette L May; C George; Frank carroll; Wayne Mascarella; K C Rice; A E Jacobson; M V Mattson
Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist.
Journal of medicinal chemistry 1988;31(12):2257-63.
1988: A Philip; J A Kepler; B H Johnson; Frank carroll
Peptide derivatives of primaquine as potential antimalarial agents.
Journal of medicinal chemistry 1988;31(4):870-4.
1988: J A Kepler; A Philip; Y W Lee; M C Morey; Frank carroll
1,2,4-Trioxanes as potential antimalarial agents.
Journal of medicinal chemistry 1988;31(4):713-6.
1987: J A Kepler; A Philip; Y W Lee; H A Musallam; Frank carroll
Endoperoxides as potential antimalarial agents.
Journal of medicinal chemistry 1987;30(8):1505-9.
1981: Frank carroll; G A Brine; K G Boldt; Edward J Cone; D Yousefnejad; D B Vaupel; W F Buchwald
Phencyclidine metabolism: resolution, structure, and biological activity of the isomers of the hydroxy metabolite, 4-phenyl-4-(1-piperidinyl)cyclohexanol.
Journal of medicinal chemistry 1981;24(9):1047-51.