Frank carroll

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Navarro Hernán A; Howard James L; Pollard Gerald T; Carroll F Ivy
Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter.
McMahon Lance R; Li Jun-Xu; Carroll F Ivy; France Charles P
Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys.
Carroll F Ivy
Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction.

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All Publications

2009: Navarro Hernán A; Howard James L; Pollard Gerald T; Carroll F Ivy
Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter.
British journal of pharmacology 2009;156(7):1178-84.
2009: McMahon Lance R; Li Jun-Xu; Carroll F Ivy; France Charles P
Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys.
Psychopharmacology 2009;203(2):411-20.
2008: Carroll F Ivy
Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction.
Annals of the New York Academy of Sciences 2008;1141():221-32.
2008: Kimmel Heather L; Negus S Stevens; Wilcox Kristin M; Ewing Sarah B; Stehouwer Jeffrey; Goodman Mark M; Votaw John R; Mello Nancy K; Carroll F Ivy; Howell Leonard L
Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys.
Pharmacology, biochemistry, and behavior 2008;90(3):453-62.
2008: Jin Chunyang; Navarro Hernán A; Page Kevin; Carroll F Ivy
Synthesis and monoamine transporter binding properties of 2beta-[3'-(substituted benzyl)isoxazol-5-yl]- and 2beta-[3'-methyl-4'-(substituted phenyl)isoxazol-5-yl]-3beta-(substituted phenyl)tropanes.
Bioorganic & medicinal chemistry 2008;16(14):6682-8.
2008: Walline Crystal C; Nichols David E; Carroll F Ivy; Barker Eric L
Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition.
The Journal of pharmacology and experimental therapeutics 2008;325(3):791-800.
2008: Jin Chunyang; Navarro Hernán A; Carroll F Ivy
Synthesis and receptor binding properties of 2beta-alkynyl and 2beta-(1,2,3-triazol)substituted 3beta-(substituted phenyl)tropane derivatives.
Bioorganic & medicinal chemistry 2008;16(10):5529-35.
2008: Cai Tingwei Bill; Zou Zhou; Thomas James B; Brieaddy Larry; Navarro Hernán A; Carroll F Ivy
Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).
Journal of medicinal chemistry 2008;51(6):1849-60.
2008: Woolverton W L; Wang Zhixia; Vasterling Theresa; Carroll F Ivy; Tallarida Ronald
Self-administration of drug mixtures by monkeys: combining drugs with comparable mechanisms of action.
Psychopharmacology 2008;196(4):575-82.
2008: Gabra Bichoy H; Smith Forrest L; Navarro Hernán A; Carroll F Ivy; Dewey William L
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
Brain research 2008;1187():58-66.
2008: Smith Emilie D; Ariane Vinson N; Zhong Desong; Berrang Bertold D; Catanzaro Jennifer L; Thomas James B; Navarro Hernán A; Gilmour Brian P; Deschamps Jeffrey; Carroll F Ivy
A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay.
Bioorganic & medicinal chemistry 2008;16(2):822-9.
2007: Carroll F Ivy; Robinson T Philip; Brieaddy Lawrence E; Atkinson Robert N; Mascarella S Wayne; Damaj M Imad; Martin Billy R; Navarro Hernán A
Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.
Journal of medicinal chemistry 2007;50(25):6383-91.
2007: Knoll Allison T; Meloni Edward G; Thomas James B; Carroll F Ivy; Carlezon William A
Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats.
The Journal of pharmacology and experimental therapeutics 2007;323(3):838-45.
2007: Gong Paul K; Blough Bruce E; Brieaddy Lawrence E; Huang Xiaodong; Kuhar Michael J; Navarro Hernán A; Carroll F Ivy
Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.
Journal of medicinal chemistry 2007;50(15):3686-95.
2007: Carroll F Ivy; Kotturi Sharadsrikar V; Navarro Hernán A; Mascarella S Wayne; Gilmour Brian P; Smith Forrest L; Gabra Bichoy H; Dewey William L
Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.
Journal of medicinal chemistry 2007;50(14):3388-91.
2007: Peterson Eric C; Gunnell Melinda; Che Yingni; Goforth Robyn L; Carroll F Ivy; Henry Ralph; Liu Huimin; Owens S Michael
Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse.
The Journal of pharmacology and experimental therapeutics 2007;322(1):30-9.
2007: Howell Leonard L; Carroll F Ivy; Votaw John R; Goodman Mark M; Kimmel Heather L
Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2007;320(2):757-65.
2007: Kimmel Heather L; O'Connor Joann A; Carroll F Ivy; Howell Leonard L
Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys.
Pharmacology, biochemistry, and behavior 2007;86(1):45-54.
2006: Carroll F Ivy; Fox Barbara S; Kuhar Michael J; Howard James L; Pollard Gerald T; Schenk Susan
Effects of dopamine transporter selective 3-phenyltropane analogs on locomotor activity, drug discrimination, and cocaine self-administration after oral administration.
European journal of pharmacology 2006;553(1-3):149-56.
2006: Thomas James B; Zhang Li; Navarro Hernan A; Carroll F Ivy
Highly potent and selective phenylmorphan-based inverse agonists of the opioid delta receptor.
Journal of medicinal chemistry 2006;49(18):5597-609.
2006: Mihalak Karla B; Carroll F Ivy; Luetje Charles W
Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.
Molecular pharmacology 2006;70(3):801-5.
2006: Carroll F Ivy; Blough Bruce E; Huang Xiaodong; Nie Zhe; Mascarella S Wayne; Deschamps Jeffrey; Navarro Hernán A
Synthesis and monoamine transporter binding properties of 2,3-cyclo analogues of 3beta-(4'-aminophenyl)-2beta-tropanemethanol.
Journal of medicinal chemistry 2006;49(15):4589-94.
2006: Carroll F Ivy; Hu Xingding; Navarro Hernán A; Deschamps Jeffrey; Abdrakhmanova Galya R; Damaj M Imad; Martin Billy R
Synthesis and pharmacological characterization of nicotinic acetylcholine receptor properties of (+)- and (-)-pyrido-[3,4-b]homotropanes.
Journal of medicinal chemistry 2006;49(11):3244-50.
2006: Abdrakhmanova Galya R; Damaj M Imad; Carroll F Ivy; Martin Billy R
2-Fluoro-3-(4-nitro-phenyl)deschloroepibatidine is a novel potent competitive antagonist of human neuronal alpha4beta2 nAChRs.
Molecular pharmacology 2006;69(6):1945-52.
2006: Kulak Jennifer M; Carroll F Ivy; Schneider Jay S
[125I]Iodomethyllycaconitine binds to alpha7 nicotinic acetylcholine receptors in monkey brain.
The European journal of neuroscience 2006;23(10):2604-10.
2006: Carroll F Ivy; Melvin Matt S; Nuckols Michel C; Mascarella S Wayne; Navarro Hernán A; Thomas James B
N-substituted 4beta-methyl-5-(3-hydroxyphenyl)-7alpha-amidomorphans are potent, selective kappa opioid receptor antagonists.
Journal of medicinal chemistry 2006;49(5):1781-91.
2006: Wee Sunmee; Carroll F Ivy; Woolverton William L
A reduced rate of in vivo dopamine transporter binding is associated with lower relative reinforcing efficacy of stimulants.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(2):351-62.
2006: Runyon Scott P; Carroll F Ivy
Dopamine transporter ligands: recent developments and therapeutic potential.
Current topics in medicinal chemistry 2006;6(17):1825-43.
2006: Carroll F Ivy; Howard James L; Howell Leonard L; Fox Barbara S; Kuhar Michael J
Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse.
The AAPS journal 2006;8(1):E196-203.
2005: Carroll F Ivy; Chaudhari Sachin; Thomas James B; Mascarella S Wayne; Gigstad Kenneth M; Deschamps Jeffrey; Navarro Hernán A
N-substituted cis-4a-(3-hydroxyphenyl)-8a-methyloctahydroisoquinolines are opioid receptor pure antagonists.
Journal of medicinal chemistry 2005;48(26):8182-93.
2005: Carroll F Ivy; Brieaddy Lawrence E; Navarro Hernán A; Damaj M I; Martin Billy R
Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.
Journal of medicinal chemistry 2005;48(23):7491-5.
2005: Kotturi Sharadsrikar V; Jiang Songchun; Chang An-Chih; Abraham Philip; Navarro Hernán A; Kuhar Michael J; Carroll F Ivy
Synthesis and monoamine transporter binding properties of 2,3-diaryltropanes.
Journal of medicinal chemistry 2005;48(23):7437-44.
2005: Carroll F Ivy; Harris Louis S; Aceto Mario D
Effects of JDTic, a selective kappa-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model.
European journal of pharmacology 2005;524(1-3):89-94.
2005: Beardsley Patrick M; Howard James L; Shelton Keith L; Carroll F Ivy
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats.
Psychopharmacology 2005;183(1):118-26.
2005: Rau Kristi S; Birdsall Elisabeth; Hanson Jarom E; Johnson-Davis Kamisha L; Carroll F Ivy; Wilkins Diana G; Gibb James W; Hanson Glen R; Fleckenstein Annette E
Bupropion increases striatal vesicular monoamine transport.
Neuropharmacology 2005;49(6):820-30.
2005: Dar D E; Thiruvazhi M; Abraham P; Kitayama S; Kopajtic T A; Gamliel A; Slusher B S; Carroll F I; Uhl G R
Structure-activity relationship of trihexyphenidyl analogs with respect to the dopamine transporter in the on going search for a cocaine inhibitor.
European journal of medicinal chemistry 2005;40(10):1013-21.
2005: Haile Colin N; Zhang Xiang Yang; Carroll F Ivy; Kosten Therese A
Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter.
Brain research 2005;1055(1-2):186-95.
2005: Carroll F Ivy; Tyagi Sameer; Blough Bruce E; Kuhar Michael J; Navarro Hernn A
Synthesis and monoamine transporter binding properties of 3alpha-(substituted phenyl)nortropane-2beta-carboxylic acid methyl esters. Norepinephrine transporter selective compounds.
Journal of medicinal chemistry 2005;48(11):3852-7.
2005: Carroll F Ivy; Blough Bruce E; Nie Zhe; Kuhar Michael J; Howell Leonard L; Navarro Hernan A
Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters.
Journal of medicinal chemistry 2005;48(8):2767-71.
2005: Runyon Scott P; Burgess Jason P; Abraham Philip; Keverline-Frantz Kathryn I; Flippen-Anderson Judy; Deschamps Jeffrey; Lewin Anita H; Navarro Hernán A; Boja John W; Kuhar Michael J; Carroll F Ivy
Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product.
Bioorganic & medicinal chemistry 2005;13(7):2439-49.
2005: Ginsburg Brett C; Kimmel Heather L; Carroll F Ivy; Goodman Mark M; Howell Leonard L
Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys.
Pharmacology, biochemistry, and behavior 2005;80(3):481-91.
2005: Carroll F Ivy; Ma Wei; Yokota Yasuno; Lee Jeffrey R; Brieaddy Lawrence E; Navarro Hernán A; Damaj M I; Martin Billy R
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists.
Journal of medicinal chemistry 2005;48(4):1221-8.
2004: Carroll F Ivy; Runyon Scott P; Abraham Philip; Navarro Hernan; Kuhar Michael J; Pollard Gerald T; Howard James L
Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers.
Journal of medicinal chemistry 2004;47(25):6401-9.
2004: Damaj M Imad; Carroll F Ivy; Eaton J Brek; Navarro Hernan A; Blough Bruce E; Mirza Sadiq; Lukas Ronald J; Martin Billy R
Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors.
Molecular pharmacology 2004;66(3):675-82.
2004: Carroll F Ivy; Ware Roy; Brieaddy Lawrence E; Navarro Hernán A; Damaj M I; Martin Billy R
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues. Novel nicotinic antagonist.
Journal of medicinal chemistry 2004;47(18):4588-94.
2004: McMillan D E; Hardwick W C; Li M; Gunnell M G; Carroll F I; Abraham P; Owens S M
Effects of murine-derived anti-methamphetamine monoclonal antibodies on (+)-methamphetamine self-administration in the rat.
The Journal of pharmacology and experimental therapeutics 2004;309(3):1248-55.
2004: Lindsey Kimberly P; Wilcox Kristin M; Votaw John R; Goodman Mark M; Plisson Christophe; Carroll F Ivy; Rice Kenner C; Howell Leonard L
Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging.
The Journal of pharmacology and experimental therapeutics 2004;309(3):959-69.
2004: Carroll F Ivy
Epibatidine structure-activity relationships.
Bioorganic & medicinal chemistry letters 2004;14(8):1889-96.
2004: Narayanan Shridhar; Lam Hoa; Carroll F Ivy; Lutfy Kabirullah
Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats.
Journal of psychiatry & neuroscience : JPN 2004;29(2):116-23.
2004: Thomas James B; Fix Scott E; Rothman Richard B; Mascarella S Wayne; Dersch Christina M; Cantrell Buddy E; Zimmerman Dennis M; Carroll F Ivy
Importance of phenolic address groups in opioid kappa receptor selective antagonists.
Journal of medicinal chemistry 2004;47(4):1070-3.
2004: Roman David L; Saldaña Shannon N; Nichols David E; Carroll F Ivy; Barker Eric L
Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters.
The Journal of pharmacology and experimental therapeutics 2004;308(2):679-87.
2004: Carroll F Ivy; Pawlush Neil; Kuhar Michael J; Pollard Gerald T; Howard James L
Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes.
Journal of medicinal chemistry 2004;47(2):296-302.
2004: Carroll F Ivy; Zhang Li; Mascarella S Wayne; Navarro Hernán A; Rothman Richard B; Cantrell Buddy E; Zimmerman Dennis M; Thomas James B
Discovery of the first N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid delta receptor antagonist activity.
Journal of medicinal chemistry 2004;47(2):281-4.
2003: Lutfy Kabirullah; Eitan Shoshana; Bryant Camron D; Yang Yu C; Saliminejad Nazli; Walwyn Wendy; Kieffer Brigitte L; Takeshima Hiroshi; Carroll F Ivy; Maidment Nigel T; Evans Christopher J
Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(32):10331-7.
2003: Rasmussen Søren G F; Adkins Erika M; Carroll F Ivy; Maresch Martin J; Gether Ulrik
Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy.
European journal of pharmacology 2003;479(1-3):13-22.
2003: Thomas James B; Atkinson Robert N; Vinson N Ariane; Catanzaro Jennifer L; Perretta Carin L; Fix Scott E; Mascarella S Wayne; Rothman Richard B; Xu Heng; Dersch Christina M; Cantrell Buddy E; Zimmerman Dennis M; Carroll F Ivy
Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.
Journal of medicinal chemistry 2003;46(14):3127-37.
2003: Hess George P; Gameiro Armanda M; Schoenfeld Ryan C; Chen Yongli; Ulrich Henning; Nye Jeffrey A; Sit Barbara; Carroll F Ivy; Ganem Bruce
Reversing the action of noncompetitive inhibitors (MK-801 and cocaine) on a protein (nicotinic acetylcholine receptor)-mediated reaction.
Biochemistry 2003;42(20):6106-14.
2003: Carroll F Ivy
2002 Medicinal Chemistry Division Award address: monoamine transporters and opioid receptors. Targets for addiction therapy.
Journal of medicinal chemistry 2003;46(10):1775-94.
2003: Byrnes-Blake Kelly A; Laurenzana Elizabeth M; Carroll F Ivy; Abraham Philip; Gentry W Brooks; Landes Reid D; Owens S Michael
Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats.
European journal of pharmacology 2003;461(2-3):119-28.
2003: Kimmel Heather L; Carroll F Ivy; Kuhar Michael J
Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum.
The Journal of pharmacology and experimental therapeutics 2003;304(1):15-21.
2002: Lutfy Kabirullah; Khaliq Imran; Carroll F Ivy; Maidment Nigel T
Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats.
Psychopharmacology 2002;164(2):168-76.
2002: Carroll F Ivy; Lee Jeffrey R; Navarro Hernán A; Ma Wei; Brieaddy Lawrence E; Abraham Philip; Damaj M I; Martin Billy R
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2',3'-disubstituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes: epibatidine analogues.
Journal of medicinal chemistry 2002;45(21):4755-61.
2002: Avalos Melva; Parker Michael J; Maddox Floyd N; Carroll F Ivy; Luetje Charles W
Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1246-52.
2002: Collins Stephanie L; Kunko Paul M; Ladenheim Bruce; Cadet Jean-Lud; Carroll F Ivy; Izenwasser Sari
Chronic cocaine increases kappa-opioid receptor density: lack of effect by selective dopamine uptake inhibitors.
Synapse (New York, N.Y.) 2002;45(3):153-8.
2002: Blough Bruce E; Keverline Kathryn I; Nie Zhe; Navarro Hernán; Kuhar Michael J; Carroll F Ivy
Synthesis and transporter binding properties of 3beta-[4'-(phenylalkyl, -phenylalkenyl, and -phenylalkynyl)phenyl]tropane-2beta-carboxylic acid methyl esters: evidence of a remote phenyl binding domain on the dopamine transporter.
Journal of medicinal chemistry 2002;45(18):4029-37.
2002: Thomas James B; Atkinson Robert N; Namdev Nivedita; Rothman Richard B; Gigstad Kenneth M; Fix Scott E; Mascarella S Wayne; Burgess Jason P; Vinson N Ariane; Xu Heng; Dersch Christina M; Cantrell Buddy E; Zimmerman Dennis M; Carroll F Ivy
Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.
Journal of medicinal chemistry 2002;45(16):3524-30.
2002: Wu Qun; Reith Maarten E A; Walker Q David; Kuhn Cynthia M; Carroll F Ivy; Garris Paul A
Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(14):6272-81.
2002: Navarro H A; Xu H; Zhong D; Abraham P; Carroll F I
In vitro and in vivo characterization of [125I]iodomethyllycaconitine in the rat.
Synapse (New York, N.Y.) 2002;44(3):117-23.
2002: Cook Charles D; Carroll F Ivy; Beardsley Patrick M
RTI 113, a 3-phenyltropane analog, produces long-lasting cocaine-like discriminative stimulus effects in rats and squirrel monkeys.
European journal of pharmacology 2002;442(1-2):93-8.
2002: Rothman Richard B; Carroll F Ivy; Morales Marisela; Rowley Daniel L; Rice Kenner C; Dersch Christina M; Donovan David M
Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice.
Synapse (New York, N.Y.) 2002;44(2):94-105.
2002: Rothman Richard B; Dersch Christina M; Carroll F Ivy; Ananthan Subramaniam
Studies of the biogenic amine transporters. VIII: identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding.
Synapse (New York, N.Y.) 2002;43(4):268-74.
2002: Wilcox K M; Lindsey K P; Votaw J R; Goodman M M; Martarello L; Carroll F I; Howell L L
Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys.
Synapse (New York, N.Y.) 2002;43(1):78-85.
2001: Kimmel H L; Carroll F I; Kuhar M J
Locomotor stimulant effects of novel phenyltropanes in the mouse.
Drug and alcohol dependence 2001;65(1):25-36.
2001: Carroll F I; Lee J R; Navarro H A; Brieaddy L E; Abraham P; Damaj M I; Martin B R
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted-3'-phenyl-5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel nicotinic antagonist.
Journal of medicinal chemistry 2001;44(24):4039-41.
2001: Zaki P A; Keith D E; Thomas J B; Carroll F I; Evans C J
Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation.
The Journal of pharmacology and experimental therapeutics 2001;298(3):1015-20.
2001: Navarro H A; Xu H; Zhong D; Blough B E; Ross W P; Kuhar M J; Carroll F I
[(125)I]3beta-(4-ethyl-3-iodophenyl)nortropane-2beta-carboxylic acid methyl ester ([(125)I]EINT): a potent and selective radioligand for the brain serotonin transporter.
Synapse (New York, N.Y.) 2001;41(3):241-7.
2001: Thomas J B; Atkinson R N; Rothman R B; Fix S E; Mascarella S W; Vinson N A; Xu H; Dersch C M; Lu Y; Cantrell B E; Zimmerman D M; Carroll F I
Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.
Journal of medicinal chemistry 2001;44(17):2687-90.
2001: Wu Q; Reith M E; Kuhar M J; Carroll F I; Garris P A
Preferential increases in nucleus accumbens dopamine after systemic cocaine administration are caused by unique characteristics of dopamine neurotransmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(16):6338-47.
2001: Kuhar M J; Carroll F I; Bharat N; Landry D W
Anticocaine catalytic antibodies have no affinity for RTI compounds: implications for treatment.
Synapse (New York, N.Y.) 2001;41(2):176-8.
2001: Kimmel H L; Joyce A R; Carroll F I; Kuhar M J
Dopamine D1 and D2 receptors influence dopamine transporter synthesis and degradation in the rat.
The Journal of pharmacology and experimental therapeutics 2001;298(1):129-40.
2001: Carroll F I; Liang F; Navarro H A; Brieaddy L E; Abraham P; Damaj M I; Martin B R
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues.
Journal of medicinal chemistry 2001;44(13):2229-37.
2001: Xu H; Lu Y F; Thomas J B; Carroll F I; Rice K C; Rothman R B
Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor.
Synapse (New York, N.Y.) 2001;40(4):269-74.
2001: Kimmel H L; Carroll F I; Kuhar M J
RTI-76, an irreversible inhibitor of dopamine transporter binding, increases locomotor activity in the rat at high doses.
Brain research 2001;897(1-2):157-63.
2001: Thomas J B; Herault X M; Rothman R B; Atkinson R N; Burgess J P; Mascarella S W; Dersch C M; Xu H; Flippen-Anderson J L; George C F; Carroll F I
Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.
Journal of medicinal chemistry 2001;44(6):972-87.
2001: Byrnes-Blake K A; Carroll F I; Abraham P; Owens S M
Generation of anti-(+)methamphetamine antibodies is not impeded by (+)methamphetamine administration during active immunization of rats.
International immunopharmacology 2001;1(2):329-38.
2001: Rasmussen S G; Carroll F I; Maresch M J; Jensen A D; Tate C G; Gether U
Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter.
The Journal of biological chemistry 2001;276(7):4717-23.
2001: Xu H; Hashimoto A; Rice K C; Jacobson A E; Thomas J B; Carroll F I; Lai J; Rothman R B
Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay.
Synapse (New York, N.Y.) 2001;39(1):64-9.
2001: Rothman R B; Baumann M H; Dersch C M; Romero D V; Rice K C; Carroll F I; Partilla J S
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.
Synapse (New York, N.Y.) 2001;39(1):32-41.
2000: Ranaldi R; Anderson K G; Carroll F I; Woolverton W L
Reinforcing and discriminative stimulus effects of RTI 111, a 3-phenyltropane analog, in rhesus monkeys: interaction with methamphetamine.
Psychopharmacology 2000;153(1):103-10.
2000: Blough B E; Holmquist C R; Abraham P; Kuhar M J; Carroll F I
3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter.
Bioorganic & medicinal chemistry letters 2000;10(21):2445-7.
2000: Rothman R B; Partilla J S; Dersch C M; Carroll F I; Rice K C; Baumann M H
Methamphetamine dependence: medication development efforts based on the dual deficit model of stimulant addiction.
Annals of the New York Academy of Sciences 2000;914():71-81.
2000: Thomas J B; Atkinson R N; Rothman R B; Burgess J P; Mascarella S W; Dersch C M; Xu H; Carroll F I
4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.
Bioorganic & medicinal chemistry letters 2000;10(11):1281-4.
2000: Zaki P A; Keith D E; Brine G A; Carroll F I; Evans C J
Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation?
The Journal of pharmacology and experimental therapeutics 2000;292(3):1127-34.
2000: Rothman R B; Partilla J S; Baumann M H; Dersch C M; Carroll F I; Rice K C
Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse.
Synapse (New York, N.Y.) 2000;35(3):222-7.
2000: Kimmel H L; Carroll F I; Kuhar M J
Dopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76.
Neuropharmacology 2000;39(4):578-85.
1999: Thomas J B; Atkinson R N; Herault X M; Rothman R B; Mascarella S W; Dersch C M; Xu H; Horel R B; Carroll F I
Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.
Bioorganic & medicinal chemistry letters 1999;9(23):3347-50.
1999: Carroll F I; Bai X; Dehghani A; Mascarella S W; Williams W; Bowen W D
Asymmetric synthesis of 9-alkyl-2-benzyl-6,7-benzomorphans: characterization as novel sigma receptor ligands.
Journal of medicinal chemistry 1999;42(22):4621-9.
1999: Thomas J B; Herault X M; Rothman R B; Burgess J P; Mascarella S W; Xu H; Horel R B; Dersch C M; Carroll F I
(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.
Bioorganic & medicinal chemistry letters 1999;9(20):3053-6.
1999: Kuhar M J; McGirr K M; Hunter R G; Lambert P D; Garrett B E; Carroll F I
Studies of selected phenyltropanes at monoamine transporters.
Drug and alcohol dependence 1999;56(1):9-15.
1999: Carroll F I; Howell L L; Kuhar M J
Pharmacotherapies for treatment of cocaine abuse: preclinical aspects.
Journal of medicinal chemistry 1999;42(15):2721-36.
1999: Damaj M I; Slemmer J E; Carroll F I; Martin B R
Pharmacological characterization of nicotine's interaction with cocaine and cocaine analogs.
The Journal of pharmacology and experimental therapeutics 1999;289(3):1229-36.
1999: Xu H; Lu Y F; Partilla J S; Zheng Q X; Wang J B; Brine G A; Carroll F I; Rice K C; Chen K X; Chi Z Q; Rothman R B
Opioid peptide receptor studies, 11: involvement of Tyr148, Trp318 and His319 of the rat mu-opioid receptor in binding of mu-selective ligands.
Synapse (New York, N.Y.) 1999;32(1):23-8.
1999: Izenwasser S; French D; Carroll F I; Kunko P M
Continuous infusion of selective dopamine uptake inhibitors or cocaine produces time-dependent changes in rat locomotor activity.
Behavioural brain research 1999;99(2):201-8.
1998: Jiang S; Chang A C; Abraham P; Kuhar M J; Carroll F I
Synthesis and transporter binding properties of (R)-2 beta, 3 beta- and (R)-2 alpha, 3 alpha-diaryltropanes.
Bioorganic & medicinal chemistry letters 1998;8(24):3689-92.
1998: Thomas J B; Fall M J; Cooper J B; Rothman R B; Mascarella S W; Xu H; Partilla J S; Dersch C M; McCullough K B; Cantrell B E; Zimmerman D M; Carroll F I
Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.
Journal of medicinal chemistry 1998;41(26):5188-97.
1998: Thomas J B; Mascarella S W; Burgess J P; Xu H; McCullough K B; Rothman R B; Flippen-Anderson J L; George C F; Cantrell B E; Zimmerman D M; Carroll F I
N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.
Bioorganic & medicinal chemistry letters 1998;8(22):3149-52.
1998: Thomas J B; Zheng X; Mascarella S W; Rothman R B; Dersch C M; Partilla J S; Flippen-Anderson J L; George C F; Cantrell B E; Zimmerman D M; Carroll F I
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.
Journal of medicinal chemistry 1998;41(21):4143-9.
1998: Boja J W; Carroll F I; Vaughan R A; Kopajtic T; Kuhar M J
Multiple binding sites for [125I]RTI-121 and other cocaine analogs in rat frontal cerebral cortex.
Synapse (New York, N.Y.) 1998;30(1):9-17.
1998: Thomas J B; Mascarella S W; Rothman R B; Partilla J S; Xu H; McCullough K B; Dersch C M; Cantrell B E; Zimmerman D M; Carroll F I
Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.
Journal of medicinal chemistry 1998;41(11):1980-90.
1998: Rothman R B; Silverthorn M L; Glowa J R; Matecka D; Rice K C; Carroll F I; Partilla J S; Uhl G R; Vandenbergh D J; Dersch C M
Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate.
Synapse (New York, N.Y.) 1998;28(4):322-38.
1998: Lu Y F; Xu H; Liu-Chen L Y; Chen C; Partilla J S; Brine G A; Carroll F I; Rice K C; Lai J; Porreca F; Sadee W; Rothman R B
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Synapse (New York, N.Y.) 1998;28(2):117-24.
1998: Keverline-Frantz K I; Boja J W; Kuhar M J; Abraham P; Burgess J P; Lewin A H; Carroll F I
Synthesis and ligand binding of tropane ring analogues of paroxetine.
Journal of medicinal chemistry 1998;41(2):247-57.
1997: Blough B E; Abraham P; Mills A C; Lewin A H; Boja J W; Scheffel U; Kuhar M J; Carroll F I
3 Beta-(4-ethyl-3-iodophenyl)nortropane-2 beta-carboxylic acid methyl ester as a high-affinity selective ligand for the serotonin transporter.
Journal of medicinal chemistry 1997;40(24):3861-4.
1997: Liang F; Navarro H A; Abraham P; Kotian P; Ding Y S; Fowler J; Volkow N; Kuhar M J; Carroll F I
Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2'-fluoro-5'-pyridinyl)-7-azabicyclo-[2.2.1]heptane: a new positron emission tomography ligand for nicotinic receptors.
Journal of medicinal chemistry 1997;40(15):2293-5.
1997: Chang A C; Burgess J P; Mascarella S W; Abraham P; Kuhar M J; Carroll F I
Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.
Journal of medicinal chemistry 1997;40(8):1247-51.
1996: Holmquist C R; Keverline-Frantz K I; Abraham P; Boja J W; Kuhar M J; Carroll F I
3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.
Journal of medicinal chemistry 1996;39(21):4139-41.
1996: Fleckenstein A E; Pögün S; Carroll F I; Kuhar M J
Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 [3 beta-(3p-chlorophenyl) tropan-2 beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride].
The Journal of pharmacology and experimental therapeutics 1996;279(1):200-6.
1996: Fleckenstein A E; Kopajtic T A; Boja J W; Carroll F I; Kuhar M J
Highly potent cocaine analogs cause long-lasting increases in locomotor activity.
European journal of pharmacology 1996;311(2-3):109-14.
1996: Blough B E; Abraham P; Lewin A H; Kuhar M J; Boja J W; Carroll F I
Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.
Journal of medicinal chemistry 1996;39(20):4027-35.
1996: Sachs C W; Ballas L M; Mascarella S W; Safa A R; Lewin A H; Loomis C; Carroll F I; Bell R M; Fine R L
Effects of sphingosine stereoisomers on P-glycoprotein phosphorylation and vinblastine accumulation in multidrug-resistant MCF-7 cells.
Biochemical pharmacology 1996;52(4):603-12.
1996: Kotian P; Mascarella S W; Abraham P; Lewin A H; Boja J W; Kuhar M J; Carroll F I
Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.
Journal of medicinal chemistry 1996;39(14):2753-63.
1996: Lever J R; Scheffel U; Stathis M; Seltzman H H; Wyrick C D; Abraham P; Parham K; Thomas B F; Boja J W; Kuhar M J; Carroll F I
Synthesis and in vivo studies of a selective ligand for the dopamine transporter: 3 beta-(4-[125I]iodophenyl) tropan-2 beta-carboxylic acid isopropyl ester ([125I]RTI-121).
Nuclear medicine and biology 1996;23(3):277-84.
1996: Musachio J L; Keverline K I; Carroll F I; Dannals R F
3 Beta-(p-trimethylsilylphenyl)tropane-2 beta-carboxylic acid methyl ester: a new precursor for the preparation of [123I]RTI-55.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1996;47(1):79-81.
1995: Staley J K; Boja J W; Carroll F I; Seltzman H H; Wyrick C D; Lewin A H; Abraham P; Mash D C
Mapping dopamine transporters in the human brain with novel selective cocaine analog [125I]RTI-121.
Synapse (New York, N.Y.) 1995;21(4):364-72.
1995: Scheffel U; Taylor G F; Kepler J A; Carroll F I; Kuhar M J
In vivo labeling of neuronal nicotinic acetylcholine receptors with radiolabeled isomers of norchloroepibatidine.
Neuroreport 1995;6(18):2483-8.
1995: Carroll F I; Scheffel U; Dannals R F; Boja J W; Kuhar M J
Development of imaging agents for the dopamine transporter.
Medicinal research reviews 1995;15(5):419-44.
1995: Kotian P; Abraham P; Lewin A H; Mascarella S W; Boja J W; Kuhar M J; Carroll F I
Synthesis and ligand binding study of 3 beta-(4'-substituted phenyl)-2 beta-(heterocyclic)tropanes.
Journal of medicinal chemistry 1995;38(18):3451-3.
1995: Danso-Danquah R; Bai X; Zhang X; Mascarella S W; Williams W; Sine B; Bowen W D; Carroll F I
Synthesis and sigma binding properties of 1'- and 3'-halo- and 1',3'-dihalo-N-normetazocine analogues.
Journal of medicinal chemistry 1995;38(15):2986-9.
1995: Danso-Danquah R; Bai X; Zhang X; Mascarella S W; Williams W; Sine B; Bowen W D; Carroll F I
Synthesis and sigma binding properties of 2'-substituted 5,9 alpha-dimethyl-6,7-benzomorphans.
Journal of medicinal chemistry 1995;38(15):2978-85.
1995: Rothman R B; Silverthorn M L; Baumann M H; Goodman C B; Cadet J L; Matecka D; Rice K C; Carroll F I; Wang J B; Uhl G R
Studies of the biogenic amine transporters. VI. Characterization of a novel cocaine binding site, identified with [125I]RTI-55, in membranes prepared from whole rat brain minus caudate.
The Journal of pharmacology and experimental therapeutics 1995;274(1):385-95.
1995: Lewin A H; Black S L; Bos M E; Goehring R R; Nair X; Whiting G; Bouquin P; Tetrault G; Carroll F I
Evaluation of retinoid lactones as topical therapeutic agents in dermatology.
Pharmaceutical research 1995;12(7):983-92.
1995: Stathis M; Scheffel U; Lever S Z; Boja J W; Carroll F I; Kuhar M J
Rate of binding of various inhibitors at the dopamine transporter in vivo.
Psychopharmacology 1995;119(4):376-84.
1995: Brine G A; Stark P A; Liu Y; Carroll F I; Singh P; Xu H; Rothman R B
Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.
Journal of medicinal chemistry 1995;38(9):1547-57.
1995: Boja J W; Cadet J L; Kopajtic T A; Lever J; Seltzman H H; Wyrick C D; Lewin A H; Abraham P; Carroll F I
Selective labeling of the dopamine transporter by the high affinity ligand 3 beta-(4-[125I]iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester.
Molecular pharmacology 1995;47(4):779-86.
1995: Silverthorn M L; Dersch C M; Baumann M H; Cadet J L; Partilla J S; Rice K C; Carroll F I; Becketts K M; Brockington A; Rothman R B
Studies of the biogenic amine transporters. V. Demonstration of two binding sites for the cocaine analog [125I]RTI-55 associated with the 5-HT transporter in rat brain membranes.
The Journal of pharmacology and experimental therapeutics 1995;273(1):213-22.
1995: Mascarella S W; Bai X; Williams W; Sine B; Bowen W D; Carroll F I
(+)-cis-N-(para-, meta-, and ortho-substituted benzyl)-N-normetazocines: synthesis and binding affinity at the [3H]-(+)-pentazocine-labeled (sigma 1) site and quantitative structure-affinity relationship studies.
Journal of medicinal chemistry 1995;38(3):565-9.
1995: Weiser S D; Patrick S L; Mascarella S W; Downing-Park J; Bai X; Carroll F I; Walker J M; Patrick R L
Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of sigma receptor ligands.
European journal of pharmacology 1995;275(1):1-7.
1995: Carroll F I; Kotian P; Dehghani A; Gray J L; Kuzemko M A; Parham K A; Abraham P; Lewin A H; Boja J W; Kuhar M J
Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter.
Journal of medicinal chemistry 1995;38(2):379-88.
1994: Carroll F I; Mascarella S W; Kuzemko M A; Gao Y; Abraham P; Lewin A H; Boja J W; Kuhar M J
Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters.
Journal of medicinal chemistry 1994;37(18):2865-73.
1994: Rothman R B; Cadet J L; Akunne H C; Silverthorn M L; Baumann M H; Carroll F I; Rice K C; de Costa B R; Partilla J S; Wang J B
Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate membranes for the cocaine analog [125I]RTI-55.
The Journal of pharmacology and experimental therapeutics 1994;270(1):296-309.
1994: Lewin A H; Goehring R R; Zusi F C; Gendimenico G J; Nair X; Whitting G; Bouquin P; Tetrault G; Carroll F I
The requirement for a retinoic acid lactone of 11-cis, 13-cis-stereochemistry for topical dermatologic activity.
Pharmaceutical research 1994;11(7):1065-7.
1994: Boja J W; Kuhar M J; Kopajtic T; Yang E; Abraham P; Lewin A H; Carroll F I
Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.
Journal of medicinal chemistry 1994;37(8):1220-3.
1994: Akunne H C; Dersch C M; Cadet J L; Baumann M H; Char G U; Partilla J S; de Costa B R; Rice K C; Carroll F I; Rothman R B
Studies of the biogenic amine transporters. III. Demonstration of two binding sites for [3H]GBR12935 and [3H]BTCP in rat caudate membranes.
The Journal of pharmacology and experimental therapeutics 1994;268(3):1462-75.
1994: Dersch C M; Akunne H C; Partilla J S; Char G U; de Costa B R; Rice K C; Carroll F I; Rothman R B
Studies of the biogenic amine transporters. 1. Dopamine reuptake blockers inhibit [3H]mazindol binding to the dopamine transporter by a competitive mechanism: preliminary evidence for different binding domains.
Neurochemical research 1994;19(2):201-8.
1994: Lewin A H; Bos M E; Zusi F C; Nair X; Whiting G; Bouquin P; Tetrault G; Carroll F I
Evaluation of retinoids as therapeutic agents in dermatology.
Pharmaceutical research 1994;11(2):192-200.
1994: Goodman C B; Thomas D N; Pert A; Emilien B; Cadet J L; Carroll F I; Blough B E; Mascarella S W; Rogawski M A; Subramaniam S
RTI-4793-14, a new ligand with high affinity and selectivity for the (+)-MK801-insensitive [3H]1-]1-(2-thienyl)cyclohexyl]piperidine binding site (PCP site 2) of guinea pig brain.
Synapse (New York, N.Y.) 1994;16(1):59-65.
1994: Scheffel U; Dannals R F; Suehiro M; Ricaurte G A; Carroll F I; Kuhar M J; Wagner H N
Development of PET/SPECT ligands for the serotonin transporter.
NIDA research monograph 1994;138():111-30.
1993: Ni Q; Xu H; Partilla J S; Stark P A; Carroll F I; Brine G A; Rothman R B
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains.
Synapse (New York, N.Y.) 1993;15(4):296-306.
1993: Carroll F I; Gray J L; Abraham P; Kuzemko M A; Lewin A H; Boja J W; Kuhar M J
3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters.
Journal of medicinal chemistry 1993;36(20):2886-90.
1993: Walker J M; Bowen W D; Patrick S L; Williams W E; Mascarella S W; Bai X; Carroll F I
A comparison of (-)-deoxybenzomorphans devoid of opiate activity with their dextrorotatory phenolic counterparts suggests role of sigma 2 receptors in motor function.
European journal of pharmacology 1993;231(1):61-8.
1993: Rothman R B; Becketts K M; Radesca L R; de Costa B R; Rice K C; Carroll F I; Dersch C M
Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists.
Life sciences 1993;53(17):PL267-72.
1993: Carroll F I; Lewin A H; Kuhar M J; Boja J W
Cocaine receptor: a structure-activity relationship study.
NIDA research monograph 1993;134():229-37.
1992: Rothman R B; Grieg N; Kim A; De Costa B R; Rice K C; Carroll F I; Pert A
Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter.
Pharmacology, biochemistry, and behavior 1992;43(4):1135-42.
1992: Boja J W; McNeill R M; Lewin A H; Abraham P; Carroll F I; Kuhar M J
Selective dopamine transporter inhibition by cocaine analogs.
Neuroreport 1992;3(11):984-6.
1992: Scheffel U; Dannals R F; Wong D F; Yokoi F; Carroll F I; Kuhar M J
Dopamine transporter imaging with novel, selective cocaine analogs.
Neuroreport 1992;3(11):969-72.
1992: Cline E J; Scheffel U; Boja J W; Mitchell W M; Carroll F I; Abraham P; Lewin A H; Kuhar M J
In vivo binding of [125I]RTI-55 to dopamine transporters: pharmacology and regional distribution with autoradiography.
Synapse (New York, N.Y.) 1992;12(1):37-46.
1992: Boja J W; Mitchell W M; Patel A; Kopajtic T A; Carroll F I; Lewin A H; Abraham P; Kuhar M J
High-affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain.
Synapse (New York, N.Y.) 1992;12(1):27-36.
1992: Carroll F I; Abraham P; Parham K; Bai X; Zhang X; Brine G A; Mascarella S W; Martin B R; May E L; Sauss C
Enantiomeric N-substituted N-normetazocines: a comparative study of affinities at sigma, PCP, and mu opioid receptors.
Journal of medicinal chemistry 1992;35(15):2812-8.
1992: Boja J W; Cline E J; Carroll F I; Lewin A H; Philip A; Dannals R; Wong D; Scheffel U; Kuhar M J
High potency cocaine analogs: neurochemical, imaging, and behavioral studies.
Annals of the New York Academy of Sciences 1992;654():282-91.
1992: Carroll F I; Abraham P; Lewin A H; Parham K A; Boja J W; Kuhar M
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
Journal of medicinal chemistry 1992;35(13):2497-500.
1992: Carroll F I; Abraham P; Chemburkar S; He X C; Mascarella S W; Kwon Y W; Triggle D J
Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol.
Journal of medicinal chemistry 1992;35(12):2184-91.
1992: Scheffel U; Dannals R F; Cline E J; Ricaurte G A; Carroll F I; Abraham P; Lewin A H; Kuhar M J
[123/125I]RTI-55, an in vivo label for the serotonin transporter.
Synapse (New York, N.Y.) 1992;11(2):134-9.
1992: Carroll F I; Gao Y; Abraham P; Lewin A H; Lew R; Patel A; Boja J W; Kuhar M J
Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter.
Journal of medicinal chemistry 1992;35(10):1813-7.
1992: Carroll F I; Lewin A H; Boja J W; Kuhar M J
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Journal of medicinal chemistry 1992;35(6):969-81.
1992: Cline E J; Scheffel U; Boja J W; Carroll F I; Katz J L; Kuhar M J
Behavioral effects of novel cocaine analogs: a comparison with in vivo receptor binding potency.
The Journal of pharmacology and experimental therapeutics 1992;260(3):1174-9.
1992: Patel A; Boja J W; Lever J; Lew R; Simantov R; Carroll F I; Lewin A H; Philip A; Gao Y; Kuhar M J
A cocaine analog and a GBR analog label the same protein in rat striatal membranes.
Brain research 1992;576(1):173-4.
1992: Shaya E K; Scheffel U; Dannals R F; Ricaurte G A; Carroll F I; Wagner H N; Kuhar M J; Wong D F
In vivo imaging of dopamine reuptake sites in the primate brain using single photon emission computed tomography (SPECT) and iodine-123 labeled RTI-55.
Synapse (New York, N.Y.) 1992;10(2):169-72.
1992: Abraham P; Pitner J B; Lewin A H; Boja J W; Kuhar M J; Carroll F I
N-modified analogues of cocaine: synthesis and inhibition of binding to the cocaine receptor.
Journal of medicinal chemistry 1992;35(1):141-4.
1992: Lewin A H; Gao Y G; Abraham P; Boja J W; Kuhar M J; Carroll F I
2 beta-substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor.
Journal of medicinal chemistry 1992;35(1):135-40.
1991: Balster R L; Carroll F I; Graham J H; Mansbach R S; Rahman M A; Philip A; Lewin A H; Showalter V M
Potent substituted-3 beta-phenyltropane analogs of cocaine have cocaine-like discriminative stimulus effects.
Drug and alcohol dependence 1991;29(2):145-51.
1991: Triggle D J; Kwon Y W; Abraham P; Pitner J B; Mascarella S W; Carroll F I
Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.
Journal of medicinal chemistry 1991;34(11):3164-71.
1991: Khan W A; Mascarella S W; Lewin A H; Wyrick C D; Carroll F I; Hannun Y A
Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets.
The Biochemical journal 1991;278 ( Pt 2)():387-92.
1991: Carroll F I; Gao Y G; Rahman M A; Abraham P; Parham K; Lewin A H; Boja J W; Kuhar M J
Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters.
Journal of medicinal chemistry 1991;34(9):2719-25.
1991: Woodward J J; Mansbach R; Carroll F I; Balster R L
Cocaethylene inhibits dopamine uptake and produces cocaine-like actions in drug discrimination studies.
European journal of pharmacology 1991;197(2-3):235-6.
1991: Carroll F I; Abraham P; Mascarella S W; Singh P; Moreland C G; Sankar S S; Kwon Y W; Triggle D J
Crystal, solution, and molecular modeling structural properties and muscarinic antagonist activity of azaprophen.
Journal of medicinal chemistry 1991;34(4):1436-40.
1991: Carroll F I; Lewin A H; Abraham P; Parham K; Boja J W; Kuhar M J
Synthesis and ligand binding of cocaine isomers at the cocaine receptor.
Journal of medicinal chemistry 1991;34(3):883-6.
1991: Boja J W; Rahman M A; Philip A; Lewin A H; Carroll F I; Kuhar M J
Isothiocyanate derivatives of cocaine: irreversible inhibition of ligand binding at the dopamine transporter.
Molecular pharmacology 1991;39(3):339-45.
1991: Boja J W; Patel A; Carroll F I; Rahman M A; Philip A; Lewin A H; Kopajtic T A; Kuhar M J
[125I]RTI-55: a potent ligand for dopamine transporters.
European journal of pharmacology 1991;194(1):133-4.
1991: Nair X; Quigley J; Tramposch K M; Carroll F I; Lewin A H; Kiss I
BMY 30047: a novel topically active retinoid with low local and systemic toxicity.
The Journal of pharmacology and experimental therapeutics 1991;256(1):365-70.
1991: Carroll F I; Lewin A H
Important compounds in the cocaine class: a synthesis overview.
NIDA research monograph 1991;112():284-99.
1990: Ritz M C; Boja J W; Grigoriadis D; Zaczek R; Carroll F I; Lewis A H; Kuhar M J
[3H]WIN 35,065-2: a ligand for cocaine receptors in striatum.
Journal of neurochemistry 1990;55(5):1556-62.
1990: Carroll F I; Gopinathan M B; Philip A
S-[2-[(2'-carbamoylethyl)amino]ethyl] phosphorothioate and related compounds as potential antiradiation agents.
Journal of medicinal chemistry 1990;33(9):2501-8.
1990: Boja J W; Carroll F I; Rahman M A; Philip A; Lewin A H; Kuhar M J
New, potent cocaine analogs: ligand binding and transport studies in rat striatum.
European journal of pharmacology 1990;184(2-3):329-32.
1990: Carroll F I; Philip A; Lewin A H
Cocaine receptor--design of ligands.
NIDA research monograph 1990;96():112-21.
1990: Carroll F I; Rahman M A; Philip A; Lewin A H; Boja J W; Kuhar M J
Synthesis and receptor binding of cocaine analogs.
NIDA research monograph 1990;105():147-53.
1989: Carroll F I; Boldt K G; Huang P T; Sawyer D K; Brine G A
Synthesis of fentanyl analogs.
NIDA research monograph 1989;95():497-8.
1988: Thurkauf A; Zenk P C; Balster R L; May E L; George C; Carroll F I; Mascarella S W; Rice K C; Jacobson A E; Mattson M V
Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist.
Journal of medicinal chemistry 1988;31(12):2257-63.
1988: Philip A; Kepler J A; Johnson B H; Carroll F I
Peptide derivatives of primaquine as potential antimalarial agents.
Journal of medicinal chemistry 1988;31(4):870-4.
1988: Kepler J A; Philip A; Lee Y W; Morey M C; Carroll F I
1,2,4-Trioxanes as potential antimalarial agents.
Journal of medicinal chemistry 1988;31(4):713-6.
1987: Kepler J A; Philip A; Lee Y W; Musallam H A; Carroll F I
Endoperoxides as potential antimalarial agents.
Journal of medicinal chemistry 1987;30(8):1505-9.
1981: Carroll F I; Brine G A; Boldt K G; Cone E J; Yousefnejad D; Vaupel D B; Buchwald W F
Phencyclidine metabolism: resolution, structure, and biological activity of the isomers of the hydroxy metabolite, 4-phenyl-4-(1-piperidinyl)cyclohexanol.
Journal of medicinal chemistry 1981;24(9):1047-51.

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