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You-Wen He

Research Profile

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Physiology

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T-Lymphocyte Subsets

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Publications

TOP 3
Ming-Xiao He; You-Wen He
CFLAR/c-FLIPL: A star in the autophagy, apoptosis and necroptosis alliance.
Alexis Dunkle; Ivan Dzhagalov; Claire Gordy; You-Wen He
Transfer of CD8+ T cell memory using Bcl-2 as a marker.
M-X He; You-Wen He
A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes.

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All Publications

2013: Ming-Xiao He; You-Wen He
CFLAR/c-FLIPL: A star in the autophagy, apoptosis and necroptosis alliance.
Autophagy 2013;9(5):791-3.
2013: Alexis Dunkle; Ivan Dzhagalov; Claire Gordy; You-Wen He
Transfer of CD8+ T cell memory using Bcl-2 as a marker.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):940-7.
2013: M-X He; You-Wen He
A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes.
Cell death and differentiation 2013;20(2):188-97.
2012: Ian X McLeod; You-Wen He
Editorial: TRPV1: how thymocytes sense stress and respond with autophagy.
Journal of leukocyte biology 2012;92(3):409-11.
2012: Ian X McLeod; Wei Jia; You-Wen He
The contribution of autophagy to lymphocyte survival and homeostasis.
Immunological reviews 2012;249(1):195-204.
2012: Suman Paul; You-Wen He; Wei Jia; Anuj K Kashyap; Brian C Schaefer
Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.
Immunity 2012;36(6):947-58.
2012: Ming-Xiao He; Wei Jia; Ian X McLeod; You-Wen He
Macroautophagy in T lymphocyte development and function.
Frontiers in immunology 2012;3():22.
2012: Claire Gordy; You-Wen He
The crosstalk between autophagy and apoptosis: where does this lead?
Protein & cell 2012;3(1):17-27.
2011: Ian X McLeod; Fan Wang; Xiang Zhou; Qi-Jing Li; You-Wen He
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5051-61.
2011: Thomas F O'Brien; Sruti Srivatsan; Danli Xie; Balachandra K Gorentla; You-Wen He; Ian X McLeod; Xiaoping Zhong
Regulation of T-cell survival and mitochondrial homeostasis by TSC1.
European journal of immunology 2011;41(11):3361-70.
2011: Sarah Frush; Stavros Garantziotis; You-Wen He; Wanglei Du; Jerry P Eu; W Michael Foster; Zhuowei Li; Erin N Potts; John W Hollingsworth
The role of the extracellular matrix protein mindin in airway response to environmental airways injury.
Environmental health perspectives 2011;119(10):1403-8.
2011: Wei Jia; You-Wen He
Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(9):5313-22.
2011: B J Altman; S R Jacobs; E F Mason; Ryan Michalek; A N MacIntyre; Jonathan L Coloff; Olga Ilkayeva; W Jia; You-Wen He; Jeffrey C Rathmell
Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis.
Oncogene 2011;30(16):1855-67.
2011: Alexis Dunkle; You-Wen He
Apoptosis and autophagy in the regulation of T lymphocyte function.
Immunologic research 2011;49(1-3):70-86.
2011: Wei Jia; Heather H Pua; Qi-Jing Li; You-Wen He
Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1564-74.
2011: Claire Gordy; Heather Pua; Gregory D Sempowski; You-Wen He
Regulation of steady-state neutrophil homeostasis by macrophages.
Blood 2011;117(2):618-29.
2011: A Dunkle; Ivan Dzhagalov; You-Wen He
Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes.
Cell death & disease 2011;2():e214.
2010: A Dunkle; Ivan Dzhagalov; You-Wen He
Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2.
Cell death and differentiation 2010;17(6):994-1002.
2009: Heather H Pua; You-Wen He
Mitophagy in the little lymphocytes: an essential role for autophagy in mitochondrial clearance in T lymphocytes.
Autophagy 2009;5(5):745-6.
2009: Alexis Dunkle; You-Wen He
Identification of a tumor associated antigen that can induce tumor specific cytotoxicity.
Cancer biology & therapy 2009;8(9):844-5.
2009: Heather H Pua; Jian Guo; Masaaki Komatsu; You-Wen He
Autophagy is essential for mitochondrial clearance in mature T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4046-55.
2009: Yili Li; Chunzhang Cao; Wei Jia; Lily Yu; Min Mo; Qian Wang; Yuping Huang; Jae-Min Lim; Mayumi Ishihara; Robert Lance Wells; Parastoo Azadi; Howard Robinson; You-Wen He; Li Zhang; Roy A Mariuzza
Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule.
The EMBO journal 2009;28(3):286-97.
2009: Claire Gordy; Ivan Dzhagalov; You-Wen He
Regulation of CD8(+) T cell functions by RARgamma.
Seminars in immunology 2009;21(1):2-7.
2009: Heather H Pua; You-Wen He
Autophagy and lymphocyte homeostasis.
Current topics in microbiology and immunology 2009;335():85-105.
2009: Haibing Zhang; Stephen Rosenberg; Francis J Coffey; You-Wen He; Timothy Manser; Richard R Hardy; Jianke Zhang
A role for cFLIP in B cell proliferation and stress MAPK regulation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):207-15.
2009: Zhuowei Li; Stavros Garantziotis; Wei Jia; Erin N Potts; Sikander Lalani; Zhi Liu; You-Wen He; W Michael Foster; John W Hollingsworth
The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace.
Journal of leukocyte biology 2009;85(1):124-31.
2008: Nu Zhang; Kaycie Hopkins; You-Wen He
c-FLIP protects mature T lymphocytes from TCR-mediated killing.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5368-73.
2008: Ivan Dzhagalov; Alexis Dunkle; You-Wen He
The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):521-8.
2008: Wei Jia; Hong Li; You-Wen He
Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6255-61.
2008: Nu Zhang; Kaycie Hopkins; You-Wen He
The long isoform of cellular FLIP is essential for T lymphocyte proliferation through an NF-kappaB-independent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5506-11.
2008: Brian C Miller; Zijiang Zhao; Linda M Stephenson; Ken Cadwell; Heather H Pua; Heung Kyu Lee; Noboru N Mizushima; Akiko Iwasaki; You-Wen He; Wojciech Swat; Herbert W Virgin
The autophagy gene ATG5 plays an essential role in B lymphocyte development.
Autophagy 2008;4(3):309-14.
2008: Qing-Qing Wang; Hong Li; Timothy Oliver; Glogauer Michael; Jian Guo; You-Wen He
Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2419-28.
2008: Daniel J Klionsky; Hagai Abeliovich; Patrizia Agostinis; Devendra K Agrawal; Gjumrakch Aliev; David S Askew; Misuzu Baba; Eric H Baehrecke; Ben A Bahr; Andrea Ballabio; Bruce A Bamber; Diane C Bassham; Ettore Bergamini; Xiaoning Bi; Martine Biard-Piechaczyk; Janice S Blum; Dale E Bredesen; Jeffrey L Brodsky; John H Brumell; Ulf T Brunk; Wilfried Bursch; Nadine Camougrand; Eduardo Cebollero; Francesco Cecconi; Yingyu Chen; Lih-Shen Chin; Augustine Choi; Charleen T Chu; Jongkyeong Chung; Peter G H Clarke; Robert S B Clark; Steven G Clarke; Corinne Clavé; John L Cleveland; Patrice Codogno; María I Colombo; Ana Coto-Montes; James M Cregg; Ana Maria Cuervo; Jayanta Debnath; Francesca Demarchi; Patrick B Dennis; Phillip A Dennis; Vojo Deretic; Rodney J Devenish; Federica Di Sano; J Fred Dice; Marian DiFiglia; Savithramma Dinesh-Kumar; Clark W Distelhorst; Mojgan Djavaheri-Mergny; Frank C Dorsey; Wulf Dröge; Michel Dron; William A Dunn; Michael Duszenko; N Tony Eissa; Zvulun Elazar; Audrey Esclatine; Eeva-Liisa Eskelinen; László Fésüs; Kim D Finley; Jose M. Fuentes; Juan Fueyo; Kozo Fujisaki; Brigitte Galliot; Fen-Biao Gao; David Gewirtz; Spencer B Gibson; Antje Gohla; Alfred L Goldberg; Ramon Gonzalez; Cristina González-Estévez; Sharon Gorski; Roberta Anne Gottlieb; Dieter Häussinger; You-Wen He; Kim Heidenreich; Joseph A Hill; Maria Høyer-Hansen; Xun Hu; Wei-Pang Huang; Akiko Iwasaki; Marja Jäättelä; William T Jackson; Xuejun Jiang; Shengkan Jin; Terje Johansen; Jae U. Jung; Motoni Kadowaki; Chanhee Kang; Ameeta Kelekar; David Kessel; Jan A K W Kiel; hong pyo kim; Adi Kimchi; Timothy J Kinsella; Kirill Kiselyov; Katsuhiko Kitamoto; Erwin Knecht; Masaaki Komatsu; Eiki Kominami; Seiji Kondo; Attila L Kovács; Guido Kroemer; Chia-Yi Kuan; Rakesh Kumar; Mondira Kundu; Jacques Landry; Marianne Laporte; Weidong Le; Huan-Yao Lei; Michael J Lenardo; Beth Levine; Andrew P Lieberman; Kah-Leong Lim; Fu-Cheng Lin; Willisa Liou; Leroy F Liu; Gabriel Lopez-Berestein; Carlos López-Otín; Bo Lu; Kay F Macleod; Walter Malorni; Wim Martinet; Ken Matsuoka; Josef Mautner; Alfred J Meijer; Alicia Meléndez; Paul Michels; Giovanni Miotto; wilhelm mistiaen; Noboru Mizushima; Baharia Mograbi; Iryna Monastyrska; Michael N Moore; Paula I Moreira; Yuji Moriyasu; Tomasz Motyl; Christian Münz; Leon O Murphy; Naweed I Naqvi; Thomas P Neufeld; Ichizo Nishino; Ralph A. Nixon; takeshi noda; Bernd Nürnberg; Michinaga Ogawa; Nancy L Oleinick; Laura J Olsen; Bulent Ozpolat; Shoshana Paglin; Glen E Palmer; Issidora Papassideri; Miles Parkes; David H Perlmutter; George Perry; Mauro Piacentini; Ronit Pinkas-Kramarski; Mark Prescott; Tassula Proikas-Cezanne; Nina Raben; Abdelhaq Rami; Fulvio Reggiori; Bärbel Rohrer; David C Rubinsztein; Kevin M Ryan; Junichi Sadoshima; Hiroshi Sakagami; Yasuyoshi Sakai; Marco Sandri; Chihiro Sasakawa; Miklós Sass; Claudio Schneider; Per O Seglen; Oleksandr Seleverstov; Jeffrey Settleman; John J Shacka; Irving M Shapiro; Andrei Sibirny; Elaine C M Silva-Zacarin; Hans-Uwe Simon; Cristiano Simone; Anne Simonsen; Mark A. Smith; Katharina Spanel-Borowski; Vickram Srinivas; Meredith Steeves; Harald Stenmark; Per E Stromhaug; Carlos S Subauste; Seiichiro Sugimoto; David Sulzer; Toshihiko Suzuki; Michele S Swanson; Ira Tabas; Fumihiko Takeshita; Nicholas J Talbot; Zsolt Tallóczy; Keiji Tanaka; Kozo Tanaka; Isei Tanida; Graham S Taylor; J. Paul Taylor; Alexei Terman; Gianluca Tettamanti; Craig Thompson; Michael Thumm; Aviva M Tolkovsky; Sharon A Tooze; Ray Truant; Lesya V Tumanovska; Yasuo Uchiyama; Takashi Ueno; Néstor L Uzcátegui; Ida van der Klei; Eva C Vaquero; Tibor Vellai; Michael W Vogel; Hong-Gang Wang; Paul Webster; John W Wiley; Zhijun Xi; Gutian Xiao; Joachim Yahalom; Jin-Ming Yang; George Yap; Xiao-Ming Yin; Tamotsu Yoshimori; Li Yu; Zhenyu Yue; Michisuke Yuzaki; Olga Zabirnyk; Xiaoxiang Zheng; Xiongwei Zhu; Russell L Deter
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy 2008;4(2):151-75.
2007: Jing-Jin Gu; Nu Zhang; You-Wen He; Anthony J Koleske; Ann Marie Pendergast
Defective T cell development and function in the absence of Abelson kinases.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7334-43.
2007: Heather H Pua; You-Wen He
Maintaining T lymphocyte homeostasis: another duty of autophagy.
Autophagy 2007;3(3):266-7.
2007: Ivan Dzhagalov; Pierre Chambon; You-Wen He
Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2113-21.
2007: Ivan Dzhagalov; Ashley St John; You-Wen He
The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages.
Blood 2007;109(4):1620-6.
2007: Heather H Pua; Ivan Dzhagalov; Mariana Chuck; Noboru Mizushima; You-Wen He
A critical role for the autophagy gene Atg5 in T cell survival and proliferation.
The Journal of experimental medicine 2007;204(1):25-31.
2006: Hong Li; Timothy Oliver; Wei Jia; You-Wen He
Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin.
The EMBO journal 2006;25(17):4097-107.
2006: David W Draper; Heather N Bethea; You-Wen He
Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci.
Immunology letters 2006;102(2):202-14.
2005: Wei Jia; Hong Li; You-Wen He
The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment.
Blood 2005;106(12):3854-9.
2005: Nu Zhang; Heather Hartig; Ivan Dzhagalov; David Draper; You-Wen He
The role of apoptosis in the development and function of T lymphocytes.
Cell research 2005;15(10):749-69.
2005: Jun Zhang; Jian Guo; Ivan Dzhagalov; You-Wen He
An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.
Nature immunology 2005;6(9):911-9.
2005: Nu Zhang; You-Wen He
An essential role for c-FLIP in the efficient development of mature T lymphocytes.
The Journal of experimental medicine 2005;202(3):395-404.
2005: Nu Zhang; You-Wen He
The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6967-73.
2004: Ivan Dzhagalov; Nu Zhang; You-Wen He
The roles of orphan nuclear receptors in the development and function of the immune system.
Cellular & molecular immunology 2004;1(6):401-7.
2004: Ivan Dzhagalov; Vincent Giguère; You-Wen He
Lymphocyte development and function in the absence of retinoic acid-related orphan receptor alpha.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):2952-9.
2004: You-Wen He; Hong Li; Jun Zhang; Chia-Lin Hsu; Emily Lin; Nu Zhang; Jian Guo; Katherine Forbush; Michael J Bevan
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.
Nature immunology 2004;5(1):88-97.
2003: Nu Zhang; Jian Guo; You-Wen He
Lymphocyte accumulation in the spleen of retinoic acid receptor-related orphan receptor gamma-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1667-75.
2002: You-Wen He
Orphan nuclear receptors in T lymphocyte development.
Journal of leukocyte biology 2002;72(3):440-6.
2002: Jian Guo; Abbas Hawwari; Hong Li; Zuoming Sun; Sanjeev K Mahanta; Dan R Littman; Michael S Krangel; You-Wen He
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.
Nature immunology 2002;3(5):469-76.
2000: You-Wen He; Courtney Beers; ML Deftos; Ethan W Ojala; Katherine Forbush; Michael J Bevan
Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5668-74.
2000: You-Wen He
The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development.
Immunologic research 2000;22(2-3):71-82.
1999: You-Wen He; Michael J Bevan
High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis.
The Journal of experimental medicine 1999;190(12):1903-8.
1999: Thomas R Malek; BO Porter; You-Wen He
Multiple gamma c-dependent cytokines regulate T-cell development.
Immunology today 1999;20(2):71-6.
1998: You-Wen He; ML Deftos; Ethan W Ojala; Michael J Bevan
RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.
Immunity 1998;9(6):797-806.
1998: ML Deftos; You-Wen He; Ethan W Ojala; Michael J Bevan
Correlating notch signaling with thymocyte maturation.
Immunity 1998;9(6):777-86.
1998: Thomas R Malek; Robert B Levy; Rebecca Adkins; You-Wen He
Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development.
Journal of leukocyte biology 1998;63(6):643-9.
1998: You-Wen He; Thomas R Malek
The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis.
Critical reviews in immunology 1998;18(6):503-24.
1997: You-Wen He; H Nakajima; Warren J Leonard; Rebecca Adkins; Thomas R Malek
The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2592-9.
1996: You-Wen He; Thomas R Malek
Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.
The Journal of experimental medicine 1996;184(1):289-93.
1995: You-Wen He; Thomas R Malek
The IL-2 receptor gamma c chain does not function as a subunit shared by the IL-4 and IL-13 receptors. Implication for the structure of the IL-4 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):9-12.
1995: You-Wen He; Robert B Levy; Thomas R Malek
Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5689-93.
1995: Thomas R Malek; R K Furse; M L Fleming; A J Fadell; You-Wen He
Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(5):447-54.
1995: You-Wen He; Rebecca Adkins; R K Furse; Thomas R Malek
Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1596-605.