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Susan B. Horwitz

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Huang Gloria S; Arend Rebecca C; Li Maomi; Gunter Marc J; Chiu Lydia G; Horwitz Susan Band; Goldberg Gary L
Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma.
Verdier-Pinard Pascal; Pasquier Eddy; Xiao Hui; Burd Berta; Villard Claude; Lafitte Daniel; Miller Leah M; Angeletti Ruth H; Horwitz Susan Band; Braguer Diane
Tubulin proteomics: towards breaking the code.
Sun Liang; Geng Xudong; Geney Raphaël; Li Yuan; Simmerling Carlos; Li Zhong; Lauher Joseph W; Xia Shujun; Horwitz Susan B; Veith Jean M; Pera Paula; Bernacki Ralph J; Ojima Iwao
Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids.

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All Publications

2009: Huang Gloria S; Arend Rebecca C; Li Maomi; Gunter Marc J; Chiu Lydia G; Horwitz Susan Band; Goldberg Gary L
Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma.
American journal of obstetrics and gynecology 2009;200(4):457.e1-5.
2009: Verdier-Pinard Pascal; Pasquier Eddy; Xiao Hui; Burd Berta; Villard Claude; Lafitte Daniel; Miller Leah M; Angeletti Ruth H; Horwitz Susan Band; Braguer Diane
Tubulin proteomics: towards breaking the code.
Analytical biochemistry 2009;384(2):197-206.
2008: Sun Liang; Geng Xudong; Geney Raphaël; Li Yuan; Simmerling Carlos; Li Zhong; Lauher Joseph W; Xia Shujun; Horwitz Susan B; Veith Jean M; Pera Paula; Bernacki Ralph J; Ojima Iwao
Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids.
The Journal of organic chemistry 2008;73(24):9584-93.
2008: Devred Francois; Tsvetkov Philipp O; Barbier Pascale; Allegro Diane; Horwitz Susan Band; Makarov Alexander A; Peyrot Vincent
Stathmin/Op18 is a novel mediator of vinblastine activity.
FEBS letters 2008;582(17):2484-8.
2008: Miller Leah M; Menthena Anuradha; Chatterjee Champak; Verdier-Pinard Pascal; Novikoff Phyllis M; Horwitz Susan Band; Angeletti Ruth Hogue
Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer.
Biochemistry 2008;47(28):7572-82.
2008: Jordan Mary Ann; Horwitz Susan Band; Lobert Sharon; Correia John J
Exploring the mechanisms of action of the novel microtubule inhibitor vinflunine.
Seminars in oncology 2008;35(3 Suppl 3):S6-S12.
2008: Horwitz Susan Band
Introduction. The novel microtubule inhibitor vinflunine.
Seminars in oncology 2008;35(3 Suppl 3):S1-2.
2008: Ojima Iwao; Chen Jin; Sun Liang; Borella Christopher P; Wang Tao; Miller Michael L; Lin Songnian; Geng Xudong; Kuznetsova Larisa; Qu Chuanxing; Gallager David; Zhao Xianrui; Zanardi Ilaria; Xia Shujun; Horwitz Susan B; Mallen-St Clair Jon; Guerriero Jennifer L; Bar-Sagi Dafna; Veith Jean M; Pera Paula; Bernacki Ralph J
Design, synthesis, and biological evaluation of new-generation taxoids.
Journal of medicinal chemistry 2008;51(11):3203-21.
2008: Goel Sanjay; Cohen Marvin; Cömezoglu S Nilgün; Perrin Lionel; André François; Jayabalan David; Iacono Lisa; Comprelli Adriana; Ly Van T; Zhang Donglu; Xu Carrie; Humphreys W Griffith; McDaid Hayley; Goldberg Gary; Horwitz Susan B; Mani Sridhar
The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2701-9.
2007: Legrier Marie-Emmanuelle; Yang Chia-Ping Huang; Yan Han-Guang; Lopez-Barcons Lluis; Keller Steven M; Pérez-Soler Roman; Horwitz Susan Band; McDaid Hayley M
Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression.
Cancer research 2007;67(23):11300-8.
2007: Wiesen Kenneth M; Xia Shujun; Yang Chia-Ping Huang; Horwitz Susan Band
Wild-type class I beta-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a beta-tubulin mutation.
Cancer letters 2007;257(2):227-35.
2007: Mani S; McDaid H M; Grossman A; Muggia F; Goel S; Griffin T; Colevas D; Horwitz S B; Egorin M J
Peripheral blood mononuclear and tumor cell pharmacodynamics of the novel epothilone B analogue, ixabepilone.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(1):190-5.
2006: Xia Shujun; Kenesky Craig S; Rucker Paul V; Smith Amos B; Orr George A; Horwitz Susan Band
A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin.
Biochemistry 2006;45(39):11762-75.
2006: Xiao Hui; Verdier-Pinard Pascal; Fernandez-Fuentes Narcis; Burd Berta; Angeletti Ruth; Fiser Andras; Horwitz Susan Band; Orr George A
Insights into the mechanism of microtubule stabilization by Taxol.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10166-73.
2006: Huang Gloria S; Lopez-Barcons Lluis; Freeze B Scott; Smith Amos B; Goldberg Gary L; Horwitz Susan Band; McDaid Hayley M
Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):298-304.
2005: Verdier-Pinard Pascal; Shahabi Shohreh; Wang Fang; Burd Berta; Xiao Hui; Goldberg Gary L; Orr George A; Horwitz Susan Band
Detection of human betaV-tubulin expression in epithelial cancer cell lines by tubulin proteomics.
Biochemistry 2005;44(48):15858-70.
2005: Smith Amos B; Rucker Paul V; Brouard Ignacio; Freeze B Scott; Xia Shujun; Horwitz Susan Band
Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes.
Organic letters 2005;7(23):5199-202.
2005: Ikui Amy E; Yang Chia-Ping Huang; Matsumoto Tomohiro; Horwitz Susan Band
Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy.
Cell cycle (Georgetown, Tex.) 2005;4(10):1385-8.
2005: Mani Sridhar; Huang Haiyan; Sundarababu Sumathy; Liu Wenjing; Kalpana Ganjam; Smith Amos B; Horwitz Susan B
Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6359-69.
2005: Yang Chia-Ping Huang; Verdier-Pinard Pascal; Wang Fang; Lippaine-Horvath Eva; He Lifeng; Li Dansu; Höfle Gerhard; Ojima Iwao; Orr George A; Horwitz Susan Band
A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.
Molecular cancer therapeutics 2005;4(6):987-95.
2005: McDaid Hayley M; Lopez-Barcons Lluis; Grossman Aaron; Lia Marie; Keller Steven; Pérez-Soler Román; Horwitz Susan Band
Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants.
Cancer research 2005;65(7):2854-60.
2005: Geney Raphaël; Sun Liang; Pera Paula; Bernacki Ralph J; Xia Shujun; Horwitz Susan B; Simmerling Carlos L; Ojima Iwao
Use of the tubulin bound paclitaxel conformation for structure-based rational drug design.
Chemistry & biology 2005;12(3):339-48.
2005: Klein Laura E; Freeze B Scott; Smith Amos B; Horwitz Susan Band
The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence.
Cell cycle (Georgetown, Tex.) 2005;4(3):501-7.
2005: Smith Amos B; Freeze B Scott; Lamarche Matthew J; Hirose Tomoyasu; Brouard Ignacio; Xian Ming; Sundermann Kurt F; Shaw Simon J; Burlingame Mark A; Horwitz Susan Band; Myles David C
Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide.
Organic letters 2005;7(2):315-8.
2005: Smith Amos B; Freeze B Scott; Lamarche Matthew J; Hirose Tomoyasu; Brouard Ignacio; Rucker Paul V; Xian Ming; Sundermann Kurt F; Shaw Simon J; Burlingame Mark A; Horwitz Susan Band; Myles David C
Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide.
Organic letters 2005;7(2):311-4.
2004: Honore Stéphane; Kamath Kathy; Braguer Diane; Horwitz Susan Band; Wilson Leslie; Briand Claudette; Jordan Mary Ann
Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells.
Cancer research 2004;64(14):4957-64.
2004: Horwitz Susan Band
Personal recollections on the early development of taxol.
Journal of natural products 2004;67(2):136-8.
2004: Mani Sridhar; McDaid Hayley; Hamilton Anne; Hochster Howard; Cohen Marvin B; Khabelle Dineo; Griffin Tom; Lebwohl David E; Liebes Leonard; Muggia Franco; Horwitz Susan Band
Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(4):1289-98.
2003: Chen Jie-Guang; Yang Chia-Ping Huang; Cammer Michael; Horwitz Susan Band
Gene expression and mitotic exit induced by microtubule-stabilizing drugs.
Cancer research 2003;63(22):7891-9.
2003: Orr George A; Verdier-Pinard Pascal; McDaid Hayley; Horwitz Susan Band
Mechanisms of Taxol resistance related to microtubules.
Oncogene 2003;22(47):7280-95.
2003: Verdier-Pinard Pascal; Wang Fang; Burd Berta; Angeletti Ruth Hogue; Horwitz Susan Band; Orr George A
Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry.
Biochemistry 2003;42(41):12019-27.
2003: Verdier-Pinard Pascal; Wang Fang; Martello Laura; Burd Berta; Orr George A; Horwitz Susan Band
Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry.
Biochemistry 2003;42(18):5349-57.
2003: Martello Laura A; Verdier-Pinard Pascal; Shen Heng-Jia; He Lifeng; Torres Keila; Orr George A; Horwitz Susan Band
Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation.
Cancer research 2003;63(6):1207-13.
2002: Biswas Kaustav; Lin Hong; Njardarson Jon T; Chappell Mark D; Chou Ting-Chao; Guan Yongbiao; Tong William P; He Lifeng; Horwitz Susan B; Danishefsky Samuel J
Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.
Journal of the American Chemical Society 2002;124(33):9825-32.
2002: McDaid Hayley M; Mani Sridhar; Shen Heng-Jia; Muggia Franco; Sonnichsen Daryl; Horwitz Susan Band
Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2035-43.
2002: Yang Chia-Ping Huang; Horwitz Susan Band
Distinct mechanisms of taxol-induced serine phosphorylation of the 66-kDa Shc isoform in A549 and RAW 264.7 cells.
Biochimica et biophysica acta 2002;1590(1-3):76-83.
2002: Chen Jie-Guang; Horwitz Susan Band
Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs.
Cancer research 2002;62(7):1935-8.
2001: He L; Yang C P; Horwitz S B
Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.
Molecular cancer therapeutics 2001;1(1):3-10.
2001: Bradley M O; Webb N L; Anthony F H; Devanesan P; Witman P A; Hemamalini S; Chander M C; Baker S D; He L; Horwitz S B; Swindell C S
Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(10):3229-38.
2001: Martello L A; LaMarche M J; He L; Beauchamp T J; Smith A B; Horwitz S B
The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies.
Chemistry & biology 2001;8(9):843-55.
2001: Gonçalves A; Braguer D; Kamath K; Martello L; Briand C; Horwitz S; Wilson L; Jordan M A
Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11737-42.
2001: Kavallaris M; Tait A S; Walsh B J; He L; Horwitz S B; Norris M D; Haber M
Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells.
Cancer research 2001;61(15):5803-9.
2001: Seidman R; Gitelman I; Sagi O; Horwitz S B; Wolfson M
The role of ERK 1/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells.
Experimental cell research 2001;268(1):84-92.
2001: McDaid H M; Horwitz S B
Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines.
Molecular pharmacology 2001;60(2):290-301.
2000: Yang C P; Horwitz S B
Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.
Cancer research 2000;60(18):5171-8.
2000: Stachel S J; Chappell M D; Lee C B; Danishefsky S J; Chou T C; He L; Horwitz S B
On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments.
Organic letters 2000;2(11):1637-9.
2000: Martello L A; McDaid H M; Regl D L; Yang C P; Meng D; Pettus T R; Kaufman M D; Arimoto H; Danishefsky S J; Smith A B; Horwitz S B
Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1978-87.
2000: He L; Jagtap P G; Kingston D G; Shen H J; Orr G A; Horwitz S B
A common pharmacophore for Taxol and the epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain.
Biochemistry 2000;39(14):3972-8.
1999: Rao S; He L; Chakravarty S; Ojima I; Orr G A; Horwitz S B
Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol.
The Journal of biological chemistry 1999;274(53):37990-4.
1999: Kavallaris M; Burkhart C A; Horwitz S B
Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol.
British journal of cancer 1999;80(7):1020-5.
1999: Ojima I; Chakravarty S; Inoue T; Lin S; He L; Horwitz S B; Kuduk S D; Danishefsky S J
A common pharmacophore for cytotoxic natural products that stabilize microtubules.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4256-61.
1999: McDaid H M; Bhattacharya S K; Chen X T; He L; Shen H J; Gutteridge C E; Horwitz S B; Danishefsky S J
Structure-activity profiles of eleutherobin analogs and their cross-resistance in Taxol-resistant cell lines.
Cancer chemotherapy and pharmacology 1999;44(2):131-7.
1998: Yang C P; Galbiati F; Volonte D; Horwitz S B; Lisanti M P
Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells.
FEBS letters 1998;439(3):368-72.
1998: Torres K; Horwitz S B
Mechanisms of Taxol-induced cell death are concentration dependent.
Cancer research 1998;58(16):3620-6.
1998: Wu Q; Bounaud P Y; Kuduk S D; Yang C P; Ojima I; Horwitz S B; Orr G A
Identification of the domains of photoincorporation of the 3'- and 7-benzophenone analogues of taxol in the carboxyl-terminal half of murine mdr1b P-glycoprotein.
Biochemistry 1998;37(32):11272-9.
1998: Orr G A; Rao S; Swindell C S; Kingston D G; Horwitz S B
Photoaffinity labeling approach to map the Taxol-binding site on the microtubule.
Methods in enzymology 1998;298():238-52.
1998: Glavy J S; Wolfson M; Nieves E; Han E K; Yang C P; Horwitz S B; Orr G A
Identification of in vivo phosphorylation sites for basic-directed kinases in murine mdr1b P-glycoprotein by combination of mass spectrometry and site-directed mutagenesis.
Methods in enzymology 1998;292():342-58.
1997: Kavallaris M; Kuo D Y; Burkhart C A; Regl D L; Norris M D; Haber M; Horwitz S B
Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.
The Journal of clinical investigation 1997;100(5):1282-93.
1997: Mallick S; Horwitz S B
Transcriptional regulation of the murine multidrug resistance gene mdr1b by progesterone occurs via an indirect mechanism.
DNA and cell biology 1997;16(7):807-18.
1997: Horwitz S B; Shen H J; He L; Dittmar P; Neef R; Chen J; Schubart U K
The microtubule-destabilizing activity of metablastin (p19) is controlled by phosphorylation.
The Journal of biological chemistry 1997;272(13):8129-32.
1997: O'Boyle K P; Wang Y; Schwartz E L; Regl D L; Einzig A; Dutcher J P; Wiernik P H; Horwitz S B
Development of two radioimmunoassays to detect paclitaxel in sera and in cerebrospinal, ascitic, and pleural fluids.
Cancer 1997;79(5):1022-30.
1997: Glavy J S; Horwitz S B; Orr G A
Identification of the in vivo phosphorylation sites for acidic-directed kinases in murine mdr1b P-glycoprotein.
The Journal of biological chemistry 1997;272(9):5909-14.
1997: Juvvadi S R; Glavy J S; Horwitz S B; Orr G A
Domain organization of murine mdr1b P-glycoprotein: the cytoplasmic linker region is a potential dimerization domain.
Biochemical and biophysical research communications 1997;230(2):442-7.
1997: Wolfson M; Yang C P; Horwitz S B
Taxol induces tyrosine phosphorylation of Shc and its association with Grb2 in murine RAW 264.7 cells.
International journal of cancer. Journal international du cancer 1997;70(2):248-52.
1996: Kuo D Y; Mallick S; Shen H J; DeVictoria C; Jones J; Fields A L; Goldberg G L; Runowicz C D; Horwitz S B
Analysis of MDR1 expression in normal and malignant endometrium by reverse transcription-polymerase chain reaction and immunohistochemistry.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(12):1981-92.
1996: Yang C P; Kirschner L S; Yu L; Horwitz S B
Localization of sequences that influence basal and cell type-specific activity of the murine mdr2 promoter.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(9):1227-37.
1995: Yu L; Wu Q; Yang C P; Horwitz S B
Coordination of transcription factors, NF-Y and C/EBP beta, in the regulation of the mdr1b promoter.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(12):1505-12.
1995: Haber M; Burkhart C A; Regl D L; Madafiglio J; Norris M D; Horwitz S B
Altered expression of M beta 2, the class II beta-tubulin isotype, in a murine J774.2 cell line with a high level of taxol resistance.
The Journal of biological chemistry 1995;270(52):31269-75.
1995: Rao S; Orr G A; Chaudhary A G; Kingston D G; Horwitz S B
Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin.
The Journal of biological chemistry 1995;270(35):20235-8.
1995: Ojima I; Duclos O; Dormán G; Simonot B; Prestwich G D; Rao S; Lerro K A; Horwitz S B
A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein.
Journal of medicinal chemistry 1995;38(20):3891-4.
1995: Castillo G; Shen H J; Horwitz S B
A homologue of the mammalian multidrug resistance gene (mdr) is functionally expressed in the intestine of Xenopus laevis.
Biochimica et biophysica acta 1995;1262(2-3):113-23.
1994: Burkhart C A; Berman J W; Swindell C S; Horwitz S B
Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-alpha gene expression and cytotoxicity.
Cancer research 1994;54(22):5779-82.
1994: Cohen D; Yu L; Rzepka R; Horwitz S B
Identification of two nuclear protein binding sites and their role in the regulation of the murine multidrug resistance mdr1a promoter.
DNA and cell biology 1994;13(6):641-9.
1994: Swindell C S; Heerding J M; Krauss N E; Horwitz S B; Rao S; Ringel I
Characterization of two taxol photoaffinity analogues bearing azide and benzophenone-related photoreactive substituents in the A-ring side chain.
Journal of medicinal chemistry 1994;37(10):1446-9.
1994: Yang C P; Shen H J; Horwitz S B
Modulation of the function of P-glycoprotein by estramustine.
Journal of the National Cancer Institute 1994;86(9):723-5.
1994: Horwitz S B
How to make taxol from scratch.
Nature 1994;367(6464):593-4.
1994: Rao S; Krauss N E; Heerding J M; Swindell C S; Ringel I; Orr G A; Horwitz S B
3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin.
The Journal of biological chemistry 1994;269(5):3132-4.
1994: Wang L; Yang C P; Horwitz S B; Trail P A; Casazza A M
Reversal of the human and murine multidrug-resistance phenotype with megestrol acetate.
Cancer chemotherapy and pharmacology 1994;34(2):96-102.
1994: Horwitz S B
Taxol (paclitaxel): mechanisms of action.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5 Suppl 6():S3-6.
1994: Greenberger L M; Cohen D; Horwitz S B
In vitro models of multiple drug resistance.
Cancer treatment and research 1994;73():69-106.
1993: Orr G A; Han E K; Browne P C; Nieves E; O'Connor B M; Yang C P; Horwitz S B
Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites.
The Journal of biological chemistry 1993;268(33):25054-62.
1993: Cao C; Steinberg T H; Neu H C; Cohen D; Horwitz S B; Hickman S; Silverstein S C
Probenecid-resistant J774 cell expression of enhanced organic anion transport by a mechanism distinct from multidrug resistance.
Infectious agents and disease 1993;2(4):193-200.
1993: Piekarz R L; Cohen D; Horwitz S B
Progesterone regulates the murine multidrug resistance mdr1b gene.
The Journal of biological chemistry 1993;268(11):7613-6.
1993: Yu L; Cohen D; Piekarz R L; Horwitz S B
Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene.
The Journal of biological chemistry 1993;268(10):7520-6.
1993: Carboni J M; Farina V; Rao S; Hauck S I; Horwitz S B; Ringel I
Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules.
Journal of medicinal chemistry 1993;36(4):513-5.
1993: Runowicz C D; Wiernik P H; Einzig A I; Goldberg G L; Horwitz S B
Taxol in ovarian cancer.
Cancer 1993;71(4 Suppl):1591-6.
1993: Horwitz S B; Cohen D; Rao S; Ringel I; Shen H J; Yang C P
Taxol: mechanisms of action and resistance.
Journal of the National Cancer Institute. Monographs 1993;(15):55-61.
1992: Cohen D; Higman S M; Hsu S I; Horwitz S B
The involvement of a LINE-1 element in a DNA rearrangement upstream of the mdr1a gene in a taxol multidrug-resistant murine cell line.
The Journal of biological chemistry 1992;267(28):20248-54.
1992: Wolf D C; Horwitz S B
P-glycoprotein transports corticosterone and is photoaffinity-labeled by the steroid.
International journal of cancer. Journal international du cancer 1992;52(1):141-6.
1992: Rao S; Horwitz S B; Ringel I
Direct photoaffinity labeling of tubulin with taxol.
Journal of the National Cancer Institute 1992;84(10):785-8.
1992: Horwitz S B
Mechanism of action of taxol.
Trends in pharmacological sciences 1992;13(4):134-6.
1992: Meese E U; Horwitz S B; Trent J M
Evidence for linear extrachromosomal elements mediating gene amplification in the multidrug-resistant J774.2 murine cell line.
Cancer genetics and cytogenetics 1992;59(1):20-5.
1992: Kirschner L S; Greenberger L M; Hsu S I; Yang C P; Cohen D; Piekarz R L; Castillo G; Han E K; Yu L J; Horwitz S B
Biochemical and genetic characterization of the multidrug resistance phenotype in murine macrophage-like J774.2 cells.
Biochemical pharmacology 1992;43(1):77-87.
1991: Ringel I; Horwitz S B
Effect of alkaline pH on taxol-microtubule interactions.
The Journal of pharmacology and experimental therapeutics 1991;259(2):855-60.
1991: Greenberger L M; Lisanti C J; Silva J T; Horwitz S B
Domain mapping of the photoaffinity drug-binding sites in P-glycoprotein encoded by mouse mdr1b.
The Journal of biological chemistry 1991;266(31):20744-51.
1991: Swindell C S; Krauss N E; Horwitz S B; Ringel I
Biologically active taxol analogues with deleted A-ring side chain substituents and variable C-2' configurations.
Journal of medicinal chemistry 1991;34(3):1176-84.
1991: Ringel I; Horwitz S B
Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol.
Journal of the National Cancer Institute 1991;83(4):288-91.
1991: Cohen D; Piekarz R L; Hsu S I; DePinho R A; Carrasco N; Horwitz S B
Structural and functional analysis of the mouse mdr1b gene promoter.
The Journal of biological chemistry 1991;266(4):2239-44.
1991: Chabner B A; Horwitz S B; Clendennin N J; Purvis J D
Vinca alkaloids.
Cancer chemotherapy and biological response modifiers 1991;12():67-73.
1990: Hsu S I; Cohen D; Kirschner L S; Lothstein L; Hartstein M; Horwitz S B
Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.
Molecular and cellular biology 1990;10(7):3596-606.
1990: Yang C P; Cohen D; Greenberger L M; Hsu S I; Horwitz S B
Differential transport properties of two mdr gene products are distinguished by progesterone.
The Journal of biological chemistry 1990;265(18):10282-8.
1990: Castillo G; Vera J C; Yang C P; Horwitz S B; Rosen O M
Functional expression of murine multidrug resistance in Xenopus laevis oocytes.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(12):4737-41.
1990: Greenberger L M; Yang C P; Gindin E; Horwitz S B
Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.
The Journal of biological chemistry 1990;265(8):4394-401.
1990: Arceci R J; Baas F; Raponi R; Horwitz S B; Housman D; Croop J M
Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus.
Molecular reproduction and development 1990;25(2):101-9.
1990: Cohen D; Yang C P; Horwitz S B
The products of the mdr1a and mdr1b genes from multidrug resistant murine cells have similar degradation rates.
Life sciences 1990;46(7):489-95.
1990: Chabner B A; Horwitz S B
Plant alkaloids.
Cancer chemotherapy and biological response modifiers 1990;11():74-81.
1989: Greenberger L M; Croop J M; Horwitz S B; Arceci R J
P-glycoproteins encoded by mdr 1b in murine gravid uterus and multidrug resistant tumor cell lines are differentially glycosylated.
FEBS letters 1989;257(2):419-21.
1989: Lothstein L; Hsu S I; Horwitz S B; Greenberger L M
Alternate overexpression of two P-glycoprotein [corrected] genes is associated with changes in multidrug resistance in a J774.2 cell line.
The Journal of biological chemistry 1989;264(27):16054-8.
1989: Hsu S I; Lothstein L; Horwitz S B
Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes.
The Journal of biological chemistry 1989;264(20):12053-62.
1989: Yang C P; DePinho S G; Greenberger L M; Arceci R J; Horwitz S B
Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus.
The Journal of biological chemistry 1989;264(2):782-8.
1988: Slovak M L; Lothstein L; Horwitz S B; Trent J M
Molecular/cytogenetic alterations accompanying the development of multidrug resistance in the J774.2 murine cell line.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(7):453-8.
1988: Arceci R J; Croop J M; Horwitz S B; Housman D
The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4350-4.
1988: Greenberger L M; Lothstein L; Williams S S; Horwitz S B
Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3762-6.
1988: Greenberger L M; Williams S S; Georges E; Ling V; Horwitz S B
Electrophoretic analysis of P-glycoproteins produced by mouse J774.2 and Chinese hamster ovary multidrug-resistant cells.
Journal of the National Cancer Institute 1988;80(7):506-10.
1988: Yang C P; Mellado W; Horwitz S B
Azidopine photoaffinity labeling of multidrug resistance-associated glycoproteins.
Biochemical pharmacology 1988;37(7):1417-21.
1987: Mellado W; Horwitz S B
Phosphorylation of the multidrug resistance associated glycoprotein.
Biochemistry 1987;26(22):6900-4.
1987: Greenberger L M; Williams S S; Horwitz S B
Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.
The Journal of biological chemistry 1987;262(28):13685-9.
1987: Ringel I; Horwitz S B
Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium.
The Journal of pharmacology and experimental therapeutics 1987;242(2):692-8.
1987: Zeheb R; Beittenmiller H F; Horwitz S B
Use of antibodies to probe membrane glycoproteins associated with drug-resistant J774.2 cells.
Biochemical and biophysical research communications 1987;143(2):732-9.
1986: Burger R M; Projan S J; Horwitz S B; Peisach J
The DNA cleavage mechanism of iron-bleomycin. Kinetic resolution of strand scission from base propenal release.
The Journal of biological chemistry 1986;261(34):15955-9.
1986: Manfredi J J; Fant J; Horwitz S B
Taxol induces the formation of unusual arrays of cellular microtubules in colchicine-pretreated J774.2 cells.
European journal of cell biology 1986;42(1):126-34.
1986: Lothstein L; Horwitz S B
Expression of phenotypic traits following modulation of colchicine resistance in J774.2 cells.
Journal of cellular physiology 1986;127(2):253-60.
1986: Horwitz S B; Lothstein L; Manfredi J J; Mellado W; Parness J; Roy S N; Schiff P B; Sorbara L; Zeheb R
Taxol: mechanisms of action and resistance.
Annals of the New York Academy of Sciences 1986;466():733-44.
1985: Burger R M; Blanchard J S; Horwitz S B; Peisach J
The redox state of activated bleomycin.
The Journal of biological chemistry 1985;260(29):15406-9.
1985: Roy S N; Horwitz S B
A phosphoglycoprotein associated with taxol resistance in J774.2 cells.
Cancer research 1985;45(8):3856-63.
1985: Burger R M; Horwitz S B; Peisach J
Stimulation of iron(II) bleomycin activity by phosphate-containing compounds.
Biochemistry 1985;24(14):3623-9.
1985: Masurovsky E B; Peterson E R; Crain S M; Horwitz S B
Taxol effects on glia in organotypic mouse spinal cord-DRG cultures.
Cell biology international reports 1985;9(6):539-46.
1984: Mellado W; Magri N F; Kingston D G; Garcia-Arenas R; Orr G A; Horwitz S B
Preparation and biological activity of taxol acetates.
Biochemical and biophysical research communications 1984;124(2):329-36.
1984: Röyttä M; Horwitz S B; Raine C S
Taxol-induced neuropathy: short-term effects of local injection.
Journal of neurocytology 1984;13(5):685-701.
1984: Roy S N; Horwitz S B
Characterization of the association of radiolabeled bleomycin A2 with HeLa cells.
Cancer research 1984;44(4):1541-6.
1984: Manfredi J J; Horwitz S B
Vinblastine paracrystals from cultured cells are calcium-stable.
Experimental cell research 1984;150(1):205-12.
1984: Manfredi J J; Horwitz S B
Taxol: an antimitotic agent with a new mechanism of action.
Pharmacology & therapeutics 1984;25(1):83-125.
1983: Masurovsky E B; Peterson E R; Crain S M; Horwitz S B
Morphological alterations in dorsal root ganglion neurons and supporting cells of organotypic mouse spinal cord-ganglion cultures exposed to taxol.
Neuroscience 1983;10(2):491-509.
1983: Burger R M; Kent T A; Horwitz S B; Münck E; Peisach J
Mössbauer study of iron bleomycin and its activation intermediates.
The Journal of biological chemistry 1983;258(3):1559-64.
1983: Parness J; Asnes C F; Horwitz S B
Taxol binds differentially to flagellar outer doublets and their reassembled microtubules.
Cell motility 1983;3(2):123-30.
1982: Manfredi J J; Parness J; Horwitz S B
Taxol binds to cellular microtubules.
The Journal of cell biology 1982;94(3):688-96.
1982: Burger R M; Peisach J; Horwitz S B
Stoichiometry of DNA strand scission and aldehyde formation by bleomycin.
The Journal of biological chemistry 1982;257(15):8612-4.
1982: Freedman J H; Horwitz S B; Peisach J
Reduction of copper(II)-bleomycin: a model for in vivo drug activity.
Biochemistry 1982;21(9):2203-10.
1982: Burger R M; Peisach J; Horwitz S B
Effects of O2 on the reactions of activated bleomycin.
The Journal of biological chemistry 1982;257(7):3372-5.
1982: Parness J; Kingston D G; Powell R G; Harracksingh C; Horwitz S B
Structure-activity study of cytotoxicity and microtubule assembly in vitro by taxol and related taxanes.
Biochemical and biophysical research communications 1982;105(3):1082-9.
1982: Horwitz S B; Parness J; Schiff P B; Manfredi J J
Taxol: a new probe for studying the structure and function of microtubules.
Cold Spring Harbor symposia on quantitative biology 1982;46 Pt 1():219-26.
1981: Horwitz S B; Chia G H; Harracksingh C; Orlow S; Pifko-Hirst S; Schneck J; Sorbara L; Speaker M; Wilk E W; Rosen O M
Trifluoperazine inhibits phagocytosis in a macrophagelike cultured cell line.
The Journal of cell biology 1981;91(3 Pt 1):798-802.
1981: Roy S N; Orr G A; Brewer C F; Horwitz S B
Chemical synthesis of radiolabeled bleomycin A2 and its binding to DNA.
Cancer research 1981;41(11 Pt 1):4471-7.
1981: Burger R M; Peisach J; Horwitz S B
Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.
The Journal of biological chemistry 1981;256(22):11636-44.
1981: Parness J; Horwitz S B
Taxol binds to polymerized tubulin in vitro.
The Journal of cell biology 1981;91(2 Pt 1):479-87.
1981: Melnyk D L; Horwitz S B; Peisach J
Redox potential of iron-bleomycin.
Biochemistry 1981;20(18):5327-31.
1981: Masurovsky E B; Peterson E R; Crain S M; Horwitz S B
Microtubule arrays in taxol-treated mouse dorsal root ganglion-spinal cord cultures.
Brain research 1981;217(2):392-8.
1981: Baum S G; Wittner M; Nadler J P; Horwitz S B; Dennis J E; Schiff P B; Tanowitz H B
Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(7):4571-5.
1981: Schiff P B; Horwitz S B
Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins.
Biochemistry 1981;20(11):3247-52.
1981: Burger R M; Adler A D; Horwitz S B; Mims W B; Peisach J
Demonstration of nitrogen coordination in metal--bleomycin complexes by electron spin--echo envelope spectroscopy.
Biochemistry 1981;20(6):1701-4.
1981: Burger R M; Peisach J; Horwitz S B
Mechanism of bleomycin action: in vitro studies.
Life sciences 1981;28(7):715-27.
1980: Burger R M; Berkowitz A R; Peisach J; Horwitz S B
Origin of malondialdehyde from DNA degraded by Fe(II) x bleomycin.
The Journal of biological chemistry 1980;255(24):11832-8.
1980: Schiff P B; Horwitz S B
Taxol stabilizes microtubules in mouse fibroblast cells.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1561-5.
1979: Burger R M; Horwitz S B; Peisach J; Wittenberg J B
Oxygenated iron bleomycin. A short-lived intermediate in the reaction of ferrous bleomycin with O2.
The Journal of biological chemistry 1979;254(24):12999-302.
1979: Burger R M; Peisach J; Blumberg W E; Horwitz S B
Iron-bleomycin interactions with oxygen and oxygen analogues. Effects on spectra and drug activity.
The Journal of biological chemistry 1979;254(21):10906-12.
1979: Longiaru M; Ikeda J E; Jarkovsky Z; Horwitz S B; Horwitz M S
The effect of aphidicolin on adenovirus DNA synthesis.
Nucleic acids research 1979;6(10):3369-86.
1979: Brewer C F; Loike J D; Horwitz S B; Sternlicht H; Gensler W J
Conformational analysis of podophyllotoxin and its congeners. Structure--activity relationship in microtubule assembly.
Journal of medicinal chemistry 1979;22(3):215-21.
1979: Schiff P B; Fant J; Horwitz S B
Promotion of microtubule assembly in vitro by taxol.
Nature 1979;277(5698):665-7.
1978: Schiff P B; Kende A S; Horwitz S B
Steganacin: an inhibitor of HeLa cell growth and microtubule assembly in vitro.
Biochemical and biophysical research communications 1978;85(2):737-46.
1978: Sausville E A; Horwitz S B
Inhibition of SV40 DNA synthesis by camptothecin and neocarzinostatin.
Molecular pharmacology 1978;14(6):1156-66.
1978: Loike J D; Brewer C F; Sternlicht H; Gensler W J; Horwitz S B
Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congeners.
Cancer research 1978;38(9):2688-93.
1978: Burger R M; Peisach J; Horwitz S B
Effect of light and oxygen on neocarzinostatin stability and DNA-cleaving activity.
The Journal of biological chemistry 1978;253(14):4830-2.
1978: Sausville E A; Stein R W; Peisach J; Horwitz S B
Properties and products of the degradation of DNA by bleomycin and iron(II).
Biochemistry 1978;17(14):2746-54.
1978: Sausville E A; Peisach J; Horwitz S B
Effect of chelating agents and metal ions on the degradation of DNA by bleomycin.
Biochemistry 1978;17(14):2740-6.
1977: Chien M; Grollman A P; Horwitz S B
Bleomycin-DNA interactions: fluorescence and proton magnetic resonance studies.
Biochemistry 1977;16(16):2641-7.
1977: Takeshita M; Horwitz S B; Grollman A P
Mechanism of the antiviral action of bleomycin.
Annals of the New York Academy of Sciences 1977;284():367-74.
1977: Horwitz S B; Loike J D
A comparison of the mechanisms of action of VP-16-213 and podophyllotoxin.
Lloydia 1977;40(1):82-9.
1976: Liao L L; Grollman A P; Horwitz S B
Mechanism of action of the 12,13-epoxytrichothecene, anguidine, an inhibitor of protein synthesis.
Biochimica et biophysica acta 1976;454(2):273-84.
1976: Loike J D; Horwitz S B
Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells.
Biochemistry 1976;15(25):5443-8.
1976: Loike J D; Horwitz S B
Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells.
Biochemistry 1976;15(25):5435-43.
1976: Sausville E A; Peisach J; Horwitz S B
A role for ferrous ion and oxygen in the degradation of DNA by bleomycin.
Biochemical and biophysical research communications 1976;73(3):814-22.
1976: Takeshita M; Grollman A P; Horwitz S B
Effect of ATP and other nucleotides on the bleomycin-induced degradation of vaccinia virus DNA.
Virology 1976;69(2):453-63.
1976: Liao L L; Kupchan S M; Horwitz S B
Mode of action of the antitumor compound bruceantin, an inhibitor of protein synthesis.
Molecular pharmacology 1976;12(1):167-76.
1975: Horwitz S B; Bristol J A; Comins D L; Davenport R W; Kane M J; Lyle R E; Maloney J R; Portlock D E
Analogs of camptothecin.
Journal of medicinal chemistry 1975;18(5):535-7.
1975: Liao L L; Horwitz S B; Huang M T; Grollman A P; Steward D; Martin J
Triphenylmethane dyes as inhibitors of reverse transcriptase, ribonucleic acid polymerase, and protein synthesis. Structure-activity relationships.
Journal of medicinal chemistry 1975;18(1):117-20.
1974: Horwitz S B
Novel inhibitors of RNA synthesis.
Federation proceedings 1974;33(11):2281-7.
1974: Takeshita M; Horwitz S B; Grollman A P
Bleomycin, an inhibitor of vaccinia virus replication.
Virology 1974;60(2):455-65.
1974: Liebeskind D; Horwitz S B; Horwitz M S; Hsu K C
Immunoreactivity to antinucleoside antibodies in camptothecin treated HeLa cells.
Experimental cell research 1974;86(1):174-8.
1973: Horwitz S B; Horwitz M S
Effects of camptothecin on the breakage and repair of DNA during the cell cycle.
Cancer research 1973;33(11):2834-6.
1972: Horwitz S B; Chang C K; Grollman A P
Antiviral action of camptothecin.
Antimicrobial agents and chemotherapy 1972;2(5):395-401.
1971: Horwitz M S; Horwitz S B
Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin.
Biochemical and biophysical research communications 1971;45(3):723-7.
1971: Horwitz S B; Chang C K; Grollman A P
Studies on camptothecin. I. Effects of nucleic acid and protein synthesis.
Molecular pharmacology 1971;7(6):632-44.
1971: Horwitz S B; Chang S C; Grollman A P; Borkovec A B
Chemosterilant action of anthramycin: a proposed mechanism.
Science (New York, N.Y.) 1971;174(5):159-61.
1971: Borkovec A B; Chang S C; Horwitz S B
Chemosterilization of house flies with anthramycin methyl ether.
Journal of economic entomology 1971;64(4):983-4.
1969: Vogler W R; Horwitz S; Groth D P
Studies on the effects of hydroxyurea and other anticancer drugs upon pyrimidine metabolism.
Cancer research 1969;29(7):1371-8.
1969: Horwitz S B; Kwok G; Wilson L; Kisliuk R L
Diastereoisomers of formaldehyde derivatives of tetrahydrofolic acid and tetrahydroaminopterin.
Journal of medicinal chemistry 1969;12(1):49-51.
1968: Horwitz S B; Kisliuk R L
Reduced derivatives of methotrexate.
Journal of medicinal chemistry 1968;11(4):907-8.
1968: Horwitz S B; Grollman A P
Interactions of small molecules with nucleic acids. I. Mode of action of anthramycin.
Antimicrobial agents and chemotherapy 1968;8():21-4.
1964: HORWITZ S B; KAPLAN N O
HEXITOL DEHYDROGENASES OF BACILLUS SUBTILIS.
The Journal of biological chemistry 1964;239():830-8.
1962: LISS M; HORWITZ S B; KAPLAN N O
D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes.
The Journal of biological chemistry 1962;237():1342-50.

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