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Barton A. Kamen

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TOP 3
Barton A. Kamen; A K Smith
Farletuzumab, an anti-folate receptor α antibody, does not block binding of folate or anti-folates to receptor nor does it alter the potency of anti-folates in vitro.
Barton A. Kamen
What I did on my summer vacation!
Barton A. Kamen; John S Holcenberg; Joseph R Bertino; W Archie Bleyer
Are we getting closer to using methotrexate in an optimal manner?

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All Publications

2012: Barton A. Kamen; A K Smith
Farletuzumab, an anti-folate receptor α antibody, does not block binding of folate or anti-folates to receptor nor does it alter the potency of anti-folates in vitro.
Cancer chemotherapy and pharmacology 2012;70(1):113-20.
2011: Barton A. Kamen
What I did on my summer vacation!
Journal of pediatric hematology/oncology 2011;33(7):483.
2011: Barton A. Kamen; John S Holcenberg; Joseph R Bertino; W Archie Bleyer
Are we getting closer to using methotrexate in an optimal manner?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(25):3493-4; author reply 3494-5.
2010: Barton A. Kamen
Clinical aspects of pharmacogenetics of pain and co-morbidities of emotional distress.
Asian Pacific journal of cancer prevention : APJCP 2010;11 Suppl 1():27-30.
2009: Hala Elnakat; Mesfin Gonit; Marcela D'Alincourt Salazar; Juan Zhang; venkatesha basrur; William Gunning; Barton A. Kamen; Manohar Ratnam
Regulation of folate receptor internalization by protein kinase C alpha.
Biochemistry 2009;48(34):8249-60.
2009: Robert S Chapkin; Barton A. Kamen; Evelyn S Callaway; Laurie A Davidson; Nysia I George; Naisyin Wang; Joanne R Lupton; Richard H Finnell
Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer.
The Journal of nutritional biochemistry 2009;20(8):649-55.
2009: Barton A. Kamen
Serendipity-methotrexate and 6-mercaptopurine for continuation therapy for patients with acute lymphoblastic leukemia: the leukemic stem cell and beyond?
Journal of pediatric hematology/oncology 2009;31(6):383-4.
2009: Eati Basal; Guiti Z Eghbali-Fatourechi; Kimberly R Kalli; Lynn C Hartmann; Karin M Goodman; Ellen L Goode; Barton A. Kamen; Philip S Low; Keith L Knutson
Functional folate receptor alpha is elevated in the blood of ovarian cancer patients.
PloS one 2009;4(7):e6292.
2009: Peter Cole; Katherine A Beckwith; Veena Vijayanathan; Sudipta Roychowdhury; Angela K Smith; Barton A. Kamen
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia.
Pediatric neurology 2009;40(1):34-41.
2008: Barton A. Kamen
The 3 ts of therapy: typing, tailoring, and targeting.
Journal of pediatric hematology/oncology 2008;30(11):789-90.
2008: Siang-Yo Lin; Jun-Ming Yang; Allen Everett; Charles V Clevenger; Mythili Koneru; Prasun Mishra; Barton A. Kamen; Debabrata Banerjee; John Glod
The isolation of novel mesenchymal stromal cell chemotactic factors from the conditioned medium of tumor cells.
Experimental cell research 2008;314(17):3107-17.
2008: Barton A. Kamen
High-dose methotrexate: insecure rationale: take 2.
Journal of pediatric hematology/oncology 2008;30(9):639-40.
2008: Barton A. Kamen
"The odds are all or none!" An account of one family's Odyssey more than a half century ago.
Journal of pediatric hematology/oncology 2008;30(7):505-6.
2008: Peter Cole; Richard A Drachtman; Margaret Masterson; Angela K Smith; John Glod; John A Zebala; Stacey Lisi; Drew-Anne Drapala; Barton A. Kamen
Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia.
Cancer chemotherapy and pharmacology 2008;62(1):65-75.
2008: Barton A. Kamen
On maintaining the honor and sanctity of our profession: reflections and personal trials and a book review: sustaining the dignity and nobility of medical care.
Journal of pediatric hematology/oncology 2008;30(3):187-8.
2008: Jan B Wollack; Benedette Makori; Stuti Ahlawat; Rajeth Koneru; Sonia C Picinich; Angela Smith; I David Goldman; Andong Qiu; Peter Cole; John Glod; Barton A. Kamen
Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model.
Journal of neurochemistry 2008;104(6):1494-503.
2007: Bruce N Cronstein; Barton A. Kamen
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting agent for therapy of patients with acute lymphoblastic leukemia: are we there and are there pitfalls?
Journal of pediatric hematology/oncology 2007;29(12):805-7.
2007: Veena Vijayanathan; Angela K Smith; John A Zebala; Barton A. Kamen; Peter Cole
High-performance liquid chromatography separation of aminopterin-polyglutamates within red blood cells of children treated for acute lymphoblastic leukemia.
Translational research : the journal of laboratory and clinical medicine 2007;150(6):367-73.
2007: Robert C Cho; Peter Cole; Kyoung-Jin Sohn; Gregory Gaisano; Ruth Croxford; Barton A. Kamen; Young-In Kim
Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells.
Molecular cancer therapeutics 2007;6(11):2909-20.
2007: Stewart P Johnson; Barton A. Kamen; Darell D Bigner; Henry S Friedman
O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines.
Cancer chemotherapy and pharmacology 2007;60(6):883-9.
2007: Barton A. Kamen
L'asparaginase and methotrexate combinations: clashes of empiric success and laboratory models?
Journal of pediatric hematology/oncology 2007;29(9):587-8.
2007: Barton A. Kamen; Roger K Strair
What is learned from an acronym? Convergence of treatments and/or diseases?
Journal of pediatric hematology/oncology 2007;29(5):277-8.
2007: Barton A. Kamen
Megadose methylprednisolone therapy: 2 decades of experience and empiric success in need of explanation, validation, and exploitation.
Journal of pediatric hematology/oncology 2007;29(4):211-2.
2006: Darlene G Gibbon; Dale Schaar; Barton A. Kamen
A call to action: Cancer in adolescents and young adults: An unrecognized healthcare disparity.
Journal of pediatric hematology/oncology 2006;28(9):549-51.
2006: Barton A. Kamen; John Glod; Peter Cole
Metronomic therapy from a pharmacologist's view.
Journal of pediatric hematology/oncology 2006;28(6):325-7.
2006: Peter Cole; John A Zebala; María José Alcaraz; Angela K Smith; John Tan; Barton A. Kamen
Pharmacodynamic properties of methotrexate and Aminotrexate during weekly therapy.
Cancer chemotherapy and pharmacology 2006;57(6):826-34.
2006: Barton A. Kamen
Marker turned target? A case to review neprilysin in ALL (or lessons learned at the American Association for Cancer Research Meetings, 2006).
Journal of pediatric hematology/oncology 2006;28(4):201-2.
2006: Peter Cole; Barton A. Kamen
Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia.
Mental retardation and developmental disabilities research reviews 2006;12(3):174-83.
2005: Carl J Hochhauser; Michael Lewis; Barton A. Kamen; Peter Cole
Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2005;13(12):967-74.
2005: Peter Cole; Richard A Drachtman; Angela K Smith; Sarah Cate; Richard A Larson; Douglas S Hawkins; John Holcenberg; Kara Kelly; Barton A. Kamen
Phase II trial of oral aminopterin for adults and children with refractory acute leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(22):8089-96.
2005: Barton A. Kamen
Metronomic therapy: it makes sense and is patient friendly.
Journal of pediatric hematology/oncology 2005;27(11):571-2.
2005: Barton A. Kamen
Food for thought: homage to a versatile vitamin: lessons learned from nature and your mother "eat your spinach!".
Journal of pediatric hematology/oncology 2005;27(7):347-8.
2005: Elpis Mantadakis; Peter Cole; Barton A. Kamen
High-dose methotrexate in acute lymphoblastic leukemia: where is the evidence for its continued use?
Pharmacotherapy 2005;25(5):748-55.
2005: Barton A. Kamen
L-asparaginase: old dog, more tricks and leukemia: not simply a liquid tumor.
Journal of pediatric hematology/oncology 2005;27(5):243.
2005: Terzah M Horton; Susan M Blaney; Anne-Marie Langevin; John Kuhn; Barton A. Kamen; Stacey L Berg; Mark Bernstein; Steven D Weitman
Phase I trial and pharmacokinetic study of raltitrexed in children with recurrent or refractory leukemia: a pediatric oncology group study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1884-9.
2005: Barton A. Kamen
Prologue to Ignorance is the Greatest Risk.
Journal of pediatric hematology/oncology 2005;27(3):121.
2005: Barton A. Kamen; Mark Kieran
Don't throw out the baby with the bathwater!
Journal of pediatric hematology/oncology 2005;27(2):59-60.
2005: Barton A. Kamen
In the future: when is a rose is a rose is a rose?
Journal of pediatric hematology/oncology 2005;27(1):1-2.
2004: Barton A. Kamen; John Glod
What is the price of an erythrocyte and neutrophil?
Journal of pediatric hematology/oncology 2004;26(11):699-700.
2004: Robert S Kerbel; Barton A. Kamen
The anti-angiogenic basis of metronomic chemotherapy.
Nature reviews. Cancer 2004;4(6):423-36.
2004: Barton A. Kamen
High-dose methotrexate and asparaginase for the treatment of children with acute lymphoblastic leukemia: why and how?
Journal of pediatric hematology/oncology 2004;26(6):333-5.
2004: Barton A. Kamen; Angel K Smith
A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro.
Advanced drug delivery reviews 2004;56(8):1085-97.
2004: Barton A. Kamen
A tribute to and celebration of life.
Journal of pediatric hematology/oncology 2004;26(4):215-6.
2004: Yotam Kaufman; Stavit Drori; Peter Cole; Barton A. Kamen; Jenny Sirota; Ilan Ifergan; Myriam Weyl Ben Arush; Ronit Elhasid; Dvora Sahar; G J L Kaspers; Gerrit Jansen; Larry H Matherly; Gideon Rechavi; Amos Toren; Yehuda G Assaraf
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
Cancer 2004;100(4):773-82.
2004: Barton A. Kamen
The solutions for one generation may become the problems of the next.
Journal of pediatric hematology/oncology 2004;26(2):79-80.
2003: Peter Cole; Barton A. Kamen
"Beriberi" interesting!
Journal of pediatric hematology/oncology 2003;25(12):924-6.
2003: Robert S DiPaola; Henry J Durivage; Barton A. Kamen
High time for low-dose prospective clinical trials.
Cancer 2003;98(8):1559-61.
2003: Philip Frost; Barton A. Kamen
The bullseye of cancer therapy: a moving target.
Current opinion in pharmacology 2003;3(4):335-7.
2003: Ann M Winter-Vann; Barton A. Kamen; Martin O Bergo; Stephen G Young; Stepan Melnyk; S Jill James; Patrick J Casey
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6529-34.
2003: Bruce C Bostrom; Gary R Erdmann; Barton A. Kamen
Systemic methotrexate exposure is greater after intrathecal than after oral administration.
Journal of pediatric hematology/oncology 2003;25(2):114-7.
2002: Elpis Mantadakis; Angela K Smith; Linda Hynan; Naomi J Winick; Barton A. Kamen
Methotrexate polyglutamation may lack prognostic significance in children with B-cell precursor acute lymphoblastic leukemia treated with intensive oral methotrexate.
Journal of pediatric hematology/oncology 2002;24(8):636-42.
2002: Peter Cole; Angela K Smith; Barton A. Kamen
Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.
Cancer chemotherapy and pharmacology 2002;50(2):111-6.
2002: Richard A Drachtman; Peter Cole; Carla B Golden; S Jill James; Stepan Melnyk; Joseph Aisner; Barton A. Kamen
Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity.
Pediatric hematology and oncology 2002;19(5):319-27.
2002: R S Kerbel; Giannoula Klement; K I Pritchard; Barton A. Kamen
Continuous low-dose anti-angiogenic/ metronomic chemotherapy: from the research laboratory into the oncology clinic.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(1):12-5.
2001: Peter Cole; Barton A. Kamen; Richard Gorlick; D Banerjee; Angela K Smith; E Magill; J R Bertino
Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance.
Cancer research 2001;61(11):4599-604.
2000: Peter Cole; Barton A. Kamen
High-dose methotrexate is lethal to rats. Why give it to children?
Pediatric hematology and oncology 2000;17(8):609-13.
2000: E Magill; A K Smith; Barton A. Kamen
Effects of food supplementation and education on folate stores.
Pediatric hematology and oncology 2000;17(7):605-6.
2000: Barton A. Kamen; E Rubin; Joseph Aisner; E Glatstein
High-time chemotherapy or high time for low dose.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(16):2935-7.
2000: Elpis Mantadakis; L Herrera; Patrick J Leavey; Robert O Bash; Naomi J Winick; Barton A. Kamen
Fractionated cyclophosphamide and etoposide for children with advanced or refractory solid tumors: a phase II window study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(13):2576-81.
2000: Elpis Mantadakis; Angela K Smith; Barton A. Kamen
Ratio of methotrexate to folate uptake by lymphoblasts in children with B-lineage acute lymphoblastic leukemia: a pilot study.
Journal of pediatric hematology/oncology 2000;22(3):221-6.
2000: Barton A. Kamen; R Saletsky
Pain: above all, do no harm, or make sure the result is worthy of the suffering.
Pediatric hematology and oncology 2000;17(3):195-7.
2000: Michael H Woo; Jonathan J Shuster; C Chen; Robert O Bash; Frederick G. Behm; Bruce M Camitta; C A Felix; Barton A. Kamen; Ching-Hon Pui; Susana C Raimondi; Naomi J Winick; Michael D Amylon; Mary Relling
Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignancies.
Leukemia 2000;14(2):232-7.
2000: Barton A. Kamen; Richard A Drachtman
"To the heart of the matter...".
Pediatric hematology and oncology 2000;17(1):5-7.
1999: Jorge A Piedrahita; BK Oetama; Gregory D Bennett; J van Waes; Barton A. Kamen; J Richardson; S W Lacey; R G Anderson; Richard Finnell
Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development.
Nature genetics 1999;23(2):228-32.
1999: R A Farah; Barton A. Kamen
Parameningeal alveolar rhabdomyosarcoma with an isolated pancreatic metastasis.
Pediatric hematology and oncology 1999;16(5):463-7.
1999: H M Rodriguez-Cortes; James C Griener; K Hyland; Teodoro Bottiglieri; M J Bennett; Barton A. Kamen; George R Buchanan
Plasma homocysteine levels and folate status in children with sickle cell anemia.
Journal of pediatric hematology/oncology 1999;21(3):219-23.
1999: Elpis Mantadakis; Zora R Rogers; Angela K Smith; R Quigley; AF Ratliff; Barton A. Kamen
Delayed methotrexate clearance in a patient with sickle cell anemia and osteosarcoma.
Journal of pediatric hematology/oncology 1999;21(2):165-9.
1999: E Mantadakis; Barton A. Kamen
Liposomal anthracyclines for brain tumors.
Pediatric hematology and oncology 1999;16(2):89-91.
1999: Victor M Aquino; D W Fort; Barton A. Kamen
Carboplatin for the treatment of children with newly diagnosed optic chiasm gliomas: a phase II study.
Journal of neuro-oncology 1999;41(3):255-9.
1999: Charles T Quinn; Barton A. Kamen
Acute lymphoblastic leukemia complicated by choroid plexus carcinoma.
Pediatric hematology and oncology 1999;16(1):75-7.
1998: MC Hum; John Holcenberg; I Tkaczewski; J W Weaver; J Wilson; Barton A. Kamen
High-dose trimetrexate and minimal-dose leucovorin: a case for selective protection?
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):2981-4.
1998: Victor Whitehead; MJ Vuchich; Linda D Cooley; Stephen J Lauer; Donald H Mahoney; Jonathan J Shuster; C Payment; P A Koch; J J Akabutu; T Bowen; Barton A. Kamen; Yaddanapudi Ravindranath; A Emami; AT Look; G P Beardsley; D Jeanette Pullen; Bruce M Camitta
Accumulation of methotrexate polyglutamates, ploidy and trisomies of both chromosomes 4 and 10 in lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group Study.
Leukemia & lymphoma 1998;31(5-6):507-19.
1998: Cheryl M Lewis; A K Smith; Barton A. Kamen
Receptor-mediated folate uptake is positively regulated by disruption of the actin cytoskeleton.
Cancer research 1998;58(14):2952-6.
1998: Barton A. Kamen; Naomi J Winick; John Holcenberg
Oral versus intravenous methotrexate: another opinion.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(6):2283-5.
1998: Stephen J Lauer; Bruce M Camitta; B G Leventhal; D Mahoney; Jonathan J Shuster; G Kiefer; Jeanette Pullen; C Philip Steuber; Andrew J Carroll; Barton A. Kamen
Intensive alternating drug pairs after remission induction for treatment of infants with acute lymphoblastic leukemia: A Pediatric Oncology Group Pilot Study.
Journal of pediatric hematology/oncology 1998;20(3):229-33.
1998: AF Ratliff; J Wilson; MC Hum; M Marling-Cason; K Rose; Naomi J Winick; Barton A. Kamen
Phase I and pharmacokinetic trial of aminopterin in patients with refractory malignancies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(4):1458-64.
1998: C M Lewis; A K Smith; C Nguyen; Barton A. Kamen
PMA alters folate receptor distribution in the plasma membrane and increases the rate of 5-methyltetrahydrofolate delivery in mature MA104 cells.
Biochimica et biophysica acta 1998;1401(2):157-69.
1998: Victor Whitehead; MJ Vuchich; Linda D Cooley; Stephen J Lauer; Donald H Mahoney; Jonathan J Shuster; C Payment; Mark L Bernstein; J J Akabutu; T Bowen; Barton A. Kamen; Michael S Watson; AT Look; D Jeanette Pullen; Bruce M Camitta
Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(1):183-8.
1998: L Carlson; Marshall P Goren; Dorothy A Bush; James C Griener; Raymond Quigley; I Tkaczewski; Barton A. Kamen; Steven D Weitman
Toxicity, pharmacokinetics, and in vitro hemodialysis clearance of ifosfamide and metabolites in an anephric pediatric patient with Wilms' tumor.
Cancer chemotherapy and pharmacology 1998;41(2):140-6.
1998: Charles T Quinn; James C Griener; Teodoro Bottiglieri; Barton A. Kamen
Methotrexate, homocysteine, and seizures.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(1):393-4.
1997: Archie Bleyer; J A Nelson; Barton A. Kamen
Accumulation of methotrexate in systemic tissues after intrathecal administration.
Journal of pediatric hematology/oncology 1997;19(6):530-2.
1997: MC Hum; Angela K Smith; R H Lark; Naomi J Winick; Barton A. Kamen
Evidence for negative feedback of extracellular methotrexate on blasts of acute lymphoblastic leukemia in vitro.
Pharmacotherapy 1997;17(6):1260-6.
1997: Barton A. Kamen
Folate and antifolate pharmacology.
Seminars in oncology 1997;24(5 Suppl 18):S18-30-S18-39.
1997: Charles T Quinn; James C Griener; Teodoro Bottiglieri; K Hyland; A Farrow; Barton A. Kamen
Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(8):2800-6.
1996: Charles T Quinn; Barton A. Kamen
A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate rescue modalities.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 1996;44(9):522-30.
1996: Naomi J Winick; Jonathan J Shuster; W Paul Bowman; Michael J Borowitz; A Farrow; D Jacaruso; George R Buchanan; Barton A. Kamen
Intensive oral methotrexate protects against lymphoid marrow relapse in childhood B-precursor acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(10):2803-11.
1996: M L Graham; Jonathan J Shuster; Barton A. Kamen; Vita J Land; Michael J Borowitz; Bruce M Camitta; D L Cheo; M P Harrison; B G Leventhal; D P Pinkel; D Jeanette Pullen; P Steuber; Victor Whitehead
Changes in red blood cell methotrexate pharmacology and their impact on outcome when cytarabine is infused with methotrexate in the treatment of acute lymphocytic leukemia in children: a pediatric oncology group study.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(2):331-7.
1996: A Smith; M Hum; Naomi J Winick; Barton A. Kamen
A case for the use of aminopterin in treatment of patients with leukemia based on metabolic studies of blasts in vitro.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(1):69-73.
1996: M C Hum; Barton A. Kamen
Folate, antifolates, and folate analogs in pediatric oncology.
Investigational new drugs 1996;14(1):101-11.
1995: M Hum; Barton A. Kamen
Successful carboxypeptidase G2 rescue in delayed MTX-elimination due to renal failure.
Pediatric hematology and oncology 1995;12(6):521-4.
1995: David I Rosenthal; L G Close; Joseph Lucci; S C Schold; John M Truelson; H Fathallah-Skaykh; Barton A. Kamen; F Vuitch; Adi F Gazdar; James C Griener
Phase I studies of continuous-infusion paclitaxel given with standard aggressive radiation therapy for locally advanced solid tumors.
Seminars in oncology 1995;22(4 Suppl 9):13-7.
1995: Donald H Mahoney; Bruce M Camitta; B G Leventhal; Jonathan J Shuster; Curt I Civin; D J Ganick; Stephen J Lauer; C Philip Steuber; Barton A. Kamen
Repetitive low dose oral methotrexate and intravenous mercaptopurine treatment for patients with lower risk B-lineage acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study.
Cancer 1995;75(10):2623-31.
1995: J C Bernini; D W Fort; James C Griener; B J Kane; W B Chappell; Barton A. Kamen
Aminophylline for methotrexate-induced neurotoxicity.
Lancet 1995;345(8949):544-7.
1995: R B Orr; Barton A. Kamen
Identification of a point mutation in the folate receptor gene that confers a dominant negative phenotype.
Cancer research 1995;55(4):847-52.
1995: R B Orr; A R Kreisler; Barton A. Kamen
Similarity of folate receptor expression in UMSCC 38 cells to squamous cell carcinoma differentiation markers.
Journal of the National Cancer Institute 1995;87(4):299-303.
1995: Barton A. Kamen; E Frenkel; O M Colvin
Ifosfamide: should the honeymoon be over?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(2):307-9.
1994: Ning Li; D S Rosenblatt; Barton A. Kamen; Shakuntla Seetharam; Bellur Seetharam
Identification of two mutant alleles of transcobalamin II in an affected family.
Human molecular genetics 1994;3(10):1835-40.
1994: R B Orr; Barton A. Kamen
UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a mutant nonfunctional folate receptor.
Cancer research 1994;54(14):3905-11.
1994: T L Schlichtemeier; Gail Tomlinson; Barton A. Kamen; L J Waber; Golder N Wilson
Multiple coagulation defects and the Cohen syndrome.
Clinical genetics 1994;45(4):212-6.
1994: Steven D Weitman; Naomi J Winick; Barton A. Kamen
"Above all do no harm:" horizons in pediatric oncology.
Current opinion in pediatrics 1994;6(2):219-23.
1994: Barton A. Kamen; Steven D Weitman
High-dose methotrexate: is it warranted?
Pediatric hematology and oncology 1994;11(2):135-7.
1994: Eric J Smart; D C Foster; Y S Ying; Barton A. Kamen; Richard G W Anderson
Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae.
The Journal of cell biology 1994;124(3):307-13.
1994: D J Schifeling; T George; F McGuirt; R L Capizzi; Barton A. Kamen
Methotrexate content in squamous cell carcinoma of the head and neck after low-dose methotrexate.
Medical and pediatric oncology 1994;22(2):88-90.
1994: Steven D Weitman; K M Frazier; Barton A. Kamen
The folate receptor in central nervous system malignancies of childhood.
Journal of neuro-oncology 1994;21(2):107-12.
1993: D W Fort; R H Lark; A K Smith; M Marling-Cason; Steven D Weitman; B Shane; Barton A. Kamen
Accumulation of 5-methyltetrahydrofolic acid and folylpolyglutamate synthetase expression by mitogen stimulated human lymphocytes.
British journal of haematology 1993;84(4):595-601.
1993: N Winick; G R Buchanan; Barton A. Kamen
Secondary acute myeloid leukemia in Hispanic children.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(7):1433.
1993: Steven D Weitman; E Glatstein; Barton A. Kamen
Back to the basics: the importance of concentration x time in oncology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(5):820-1.
1993: Naomi J Winick; R W McKenna; Jonathan J Shuster; Nancy R Schneider; Michael J Borowitz; W Paul Bowman; D Jacaruso; Barton A. Kamen; George R Buchanan
Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(2):209-17.
1993: Giuseppe Pizzorno; A R Cashmore; B A Moroson; A D Cross; A K Smith; M Marling-Cason; Barton A. Kamen; G Peter Beardsley
5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines.
The Journal of biological chemistry 1993;268(2):1017-23.
1993: A S Pappo; T Vats; T E Williams; M Bernstein; Barton A. Kamen
Phase I trial of trimetrexate in pediatric solid tumors: a Pediatric Oncology Group study.
Medical and pediatric oncology 1993;21(4):280-2.
1992: Steven D Weitman; Arthur G Weinberg; L R Coney; V R Zurawski; D S Jennings; Barton A. Kamen
Cellular localization of the folate receptor: potential role in drug toxicity and folate homeostasis.
Cancer research 1992;52(23):6708-11.
1992: H Matsue; K G Rothberg; Akira Takashima; Barton A. Kamen; Richard G W Anderson; S W Lacey
Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6006-9.
1992: W J Chang; K G Rothberg; Barton A. Kamen; Richard G W Anderson
Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate.
The Journal of cell biology 1992;118(1):63-9.
1992: Steven D Weitman; R H Lark; L R Coney; D W Fort; Verna Frasca; V R Zurawski; Barton A. Kamen
Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues.
Cancer research 1992;52(12):3396-401.
1992: Naomi J Winick; W Paul Bowman; Barton A. Kamen; E Steve Roach; N Rollins; D Jacaruso; George R Buchanan
Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia.
Journal of the National Cancer Institute 1992;84(4):252-6.
1992: Richard G W Anderson; Barton A. Kamen; K G Rothberg; S W Lacey
Potocytosis: sequestration and transport of small molecules by caveolae.
Science (New York, N.Y.) 1992;255(5043):410-1.
1992: Peter Charles Adamson; S Zimm; A H Ragab; FRANK BALIS; Seth M Steinberg; Barton A. Kamen; Teresa J Vietti; A Gillespie; David G Poplack
A phase II trial of continuous-infusion 6-mercaptopurine for childhood leukemia.
Cancer chemotherapy and pharmacology 1992;30(2):155-7.
1992: M L Graham; Jonathan J Shuster; Barton A. Kamen; D L Cheo; M P Harrison; B G Leventhal; D Jeanette Pullen; Victor Whitehead
Red blood cell methotrexate and folate levels in children with acute lymphoblastic leukemia undergoing therapy: a Pediatric Oncology Group pilot study.
Cancer chemotherapy and pharmacology 1992;31(3):217-22.
1991: Steven D Weitman; G R Buchanan; Barton A. Kamen
Pulmonary toxicity of deferoxamine in children with advanced cancer.
Journal of the National Cancer Institute 1991;83(24):1834-5.
1991: L R Coney; Antonella Tomassetti; L Carayannopoulos; Verna Frasca; Barton A. Kamen; MI Colnaghi; V R Zurawski
Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein.
Cancer research 1991;51(22):6125-32.
1991: T Vats; Barton A. Kamen; J P Krischer
Phase II trial of ICRF-187 in children with solid tumors and acute leukemia.
Investigational new drugs 1991;9(4):333-7.
1991: Barton A. Kamen
Why more 6-mercaptopurine?
Seminars in hematology 1991;28(3 Suppl 4):12-4.
1991: Steven D Weitman; Barton A. Kamen
Fosfomycin--friend or foe?
Pediatric hematology and oncology 1991;8(3):vii-viii.
1991: Barton A. Kamen; A K Smith; Richard G W Anderson
The folate receptor works in tandem with a probenecid-sensitive carrier in MA104 cells in vitro.
The Journal of clinical investigation 1991;87(4):1442-9.
1991: O G Jonsson; Barton A. Kamen
Methotrexate and childhood leukemia.
Cancer investigation 1991;9(1):53-60.
1991: Steven D Weitman; Gregory Kato ; J L Barbosa; Barton A. Kamen
Low-dose methotrexate therapy for hepatoblastoma.
Cancer chemotherapy and pharmacology 1991;28(3):233-4.
1990: M A Gratton; Barton A. Kamen
Potentiation of cisplatin ototoxicity by noise.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(12):2091-2.
1990: K G Rothberg; Y S Ying; Barton A. Kamen; Richard G W Anderson
Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate.
The Journal of cell biology 1990;111(6 Pt 2):2931-8.
1990: M A Gratton; Richard J Salvi; Barton A. Kamen; S S Saunders
Interaction of cisplatin and noise on the peripheral auditory system.
Hearing research 1990;50(1-2):211-23.
1990: R P Castleberry; A H Ragab; C Philip Steuber; Barton A. Kamen; Stuart Toledano; K Starling; D Norris; Peter C Burger; J P Krischer
Aziridinylbenzoquinone (AZQ) in the treatment of recurrent pediatric brain and other malignant solid tumors. A Pediatric Oncology Group phase II study.
Investigational new drugs 1990;8(4):401-6.
1990: A Pappo; Ronald L Dubowy; Yaddanapudi Ravindranath; C Alvarado; S Rao; Victor Whitehead; Roger Vega; Barton A. Kamen; Teresa J Vietti
Phase II trial of trimetrexate in the treatment of recurrent childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Journal of the National Cancer Institute 1990;82(20):1641-2.
1990: K G Rothberg; Y S Ying; J F Kolhouse; Barton A. Kamen; Richard G W Anderson
The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway.
The Journal of cell biology 1990;110(3):637-49.
1990: Peter Charles Adamson; S Zimm; A H Ragab; Seth M Steinberg; FRANK BALIS; Barton A. Kamen; Teresa J Vietti; A Gillespie; David G Poplack
A phase II trial of continuous-infusion 6-mercaptopurine for childhood solid tumors.
Cancer chemotherapy and pharmacology 1990;26(5):343-4.
1989: H Arkin; T Ohnuma; Barton A. Kamen; James F Holland; S Vallabhajosula
Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
Cancer research 1989;49(23):6556-61.
1989: Barton A. Kamen; T Vietti
Evidence for CSF accumulation of 5-methyltetrahydrofolate during repeated courses of methotrexate plus folinic acid rescue.
British journal of cancer 1989;60(5):799.
1989: Barton A. Kamen; C A Johnson; M T Wang; Richard G W Anderson
Regulation of the cytoplasmic accumulation of 5-methyltetrahydrofolate in MA104 cells is independent of folate receptor regulation.
The Journal of clinical investigation 1989;84(5):1379-86.
1989: W L Furman; C B Pratt; G K Rivera; J P Krischer; Barton A. Kamen; T J Vietti
Mortality in pediatric phase I clinical trials.
Journal of the National Cancer Institute 1989;81(15):1193-4.
1989: S W Lacey; John M Sanders; K G Rothberg; Richard G W Anderson; Barton A. Kamen
Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol.
The Journal of clinical investigation 1989;84(2):715-20.
1988: Barton A. Kamen; M T Wang; A J Streckfuss; X Peryea; Richard G W Anderson
Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles.
The Journal of biological chemistry 1988;263(27):13602-9.
1988: Barton A. Kamen; Naomi J Winick
High dose methotrexate therapy: insecure rationale?
Biochemical pharmacology 1988;37(14):2713-5.
1988: G R Buchanan; Barton A. Kamen
Childhood acute leukemia as a prototype of curable cancer.
Texas medicine 1988;84(5):7-8.
1987: C B Pratt; Barton A. Kamen; N Winick; P Sartain; J E Champion; A H Ragab; M P Goren
Phase I study of iproplatin in pediatric patients: a Pediatric Oncology Group Study.
Cancer treatment reports 1987;71(1):87-8.
1987: Victor Whitehead; Barton A. Kamen; D Beaulieu
Levels of dihydrofolate reductase in livers of birds, animals, primates, and man.
Cancer drug delivery 1987;4(3):185-9.
1987: Marshall P Goren; Arlene A Forastiere; R K Wright; M E Horowitz; R K Dodge; Barton A. Kamen; M J Viar; C B Pratt
Carboplatin (CBDCA), iproplatin (CHIP), and high dose cisplatin in hypertonic saline evaluated for tubular nephrotoxicity.
Cancer chemotherapy and pharmacology 1987;19(1):57-60.
1987: Barton A. Kamen
Folate and antifolate cell binding and accumulation at physiologic folate concentrations.
NCI monographs : a publication of the National Cancer Institute 1987;(5):37-9.
1987: N J Winick; Barton A. Kamen; A Streckfuss; J Craig; F McGuirt; R L Capizzi; F Sklar; D Coln
Methotrexate (MTX) concentration in tumors following low-dose MTX.
Cancer chemotherapy and pharmacology 1987;20(1):78-80.
1987: N J Winick; Barton A. Kamen; FRANK BALIS; J Holcenberg; C M Lester; David G Poplack
Folate and methotrexate polyglutamate tissue levels in rhesus monkeys following chronic low-dose methotrexate.
Cancer drug delivery 1987;4(1):25-31.
1986: John E Moulder; J S Holcenberg; Barton A. Kamen; M Cheng; Brian L Fish
Renal irradiation and the pharmacology and toxicity of methotrexate and cisplatinum.
International journal of radiation oncology, biology, physics 1986;12(8):1415-8.
1986: T R Kinney; J P Krischer; K A Starling; C Alvarado; Barton A. Kamen
Phase II trial of mitoguazone in children with leukemia and lymphoma: a Pediatric Oncology Group Study.
Cancer treatment reports 1986;70(8):1041-2.
1986: Barton A. Kamen; A Capdevila
Receptor-mediated folate accumulation is regulated by the cellular folate content.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(16):5983-7.
1986: Barton A. Kamen; J D Caston
Properties of a folate binding protein (FBP) isolated from porcine kidney.
Biochemical pharmacology 1986;35(14):2323-9.
1986: Barton A. Kamen; James T Casper; Stephen J Lauer; Bruce M Camitta; J S Holcenberg
Treatment of refractory acute lymphoblastic leukemia with teniposide and cytarabine.
Cancer treatment reports 1986;70(7):935-6.
1986: J M Kremer; J Galivan; A Streckfuss; Barton A. Kamen
Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates.
Arthritis and rheumatism 1986;29(7):832-5.
1986: J S Holcenberg; Kendra Tutsch; R H Earhart; R S Ungerleider; Barton A. Kamen; C B Pratt; T J Gribble; D L Glaubiger
Phase I study of ICRF-187 in pediatric cancer patients and comparison of its pharmacokinetics in children and adults.
Cancer treatment reports 1986;70(6):703-9.
1986: Barton A. Kamen
Methotrexate, folate and the brain.
Neurotoxicology 1986;7(2):209-16.
1986: Barton A. Kamen; N Winick
Analysis of methotrexate polyglutamate derivatives in vivo.
Methods in enzymology 1986;122():339-46.
1985: Barton A. Kamen; N Gunther
Administering a 24-hour supply of antibiotics with a programmable, automated syringe pump.
American journal of hospital pharmacy 1985;42(12):2715-6.
1985: Barton A. Kamen; N Gunther; N Sowinsky; J Rizzo; F Marsik
Analysis of antibiotic stability in a parenteral nutrition solution.
Pediatric infectious disease 1985;4(4):387-9.
1985: S Zimm; L J Ettinger; J S Holcenberg; Barton A. Kamen; Teresa J Vietti; J Belasco; N Cogliano-Shutta; FRANK BALIS; L E Lavi; J M Collins
Phase I and clinical pharmacological study of mercaptopurine administered as a prolonged intravenous infusion.
Cancer research 1985;45(4):1869-73.
1985: R S Ungerleider; C B Pratt; T J Vietti; J S Holcenberg; Barton A. Kamen; D L Glaubiger; L F Cohen
Phase I trial of mitoxantrone in children.
Cancer treatment reports 1985;69(4):403-7.
1985: T Ohnuma; R J Lo; K J Scanlon; Barton A. Kamen; T Ohnoshi; Sandra R Wolman; J F Holland
Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro.
Cancer research 1985;45(4):1815-22.
1985: Curt I Civin; J P Krischer; Vita J Land; R Nitschke; Barton A. Kamen; T Vats
Pediatric oncology group phase II trial of amsacrine in children with solid tumors.
Cancer treatment reports 1985;69(3):335-6.
1985: Barton A. Kamen; P A Nylen; V M Whitehead; H T Abelson; B J Dolnick; D W Peterson
Lack of dihydrofolate reductase in human tumor and leukemia cells in vivo.
Cancer drug delivery 1985;2(2):133-8.
1984: Barton A. Kamen; John Moulder; L E Kun; B J Ring; S M Adams; B L Fish; J S Holcenberg
Effects of single-dose and fractionated cranial irradiation on rat brain accumulation of methotrexate.
Cancer research 1984;44(11):5092-4.
1984: G R Krakower; Barton A. Kamen
The reticulocytic rat: a model for analysis of methotrexate polyglutamate dynamics in situ.
The Journal of pharmacology and experimental therapeutics 1984;231(1):43-7.
1984: Barton A. Kamen; B Eibl; A Cashmore; J Bertino
Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro.
Biochemical pharmacology 1984;33(10):1697-9.
1984: L E Kun; B M Camitta; R K Mulhern; Stephen J Lauer; R W Kline; James T Casper; Barton A. Kamen; B M Kaplan; S W Barber
Treatment of meningeal relapse in childhood acute lymphoblastic leukemia. I. Results of craniospinal irradiation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1984;2(5):359-64.
1984: Barton A. Kamen; J S Holcenberg; K Turo; V M Whitehead
Methotrexate and folate content of erythrocytes in patients receiving oral vs intramuscular therapy with methotrexate.
The Journal of pediatrics 1984;104(1):131-3.
1983: G R Krakower; Barton A. Kamen
In situ methotrexate polyglutamate formation in rat tissues.
The Journal of pharmacology and experimental therapeutics 1983;227(3):633-8.
1983: Barton A. Kamen; W Whyte-Bauer; J R Bertino
A mechanism of resistance to methotrexate. NADPH but not NADH stimulation of methotrexate binding to dihydrofolate reductase.
Biochemical pharmacology 1983;32(12):1837-41.
1983: G R Krakower; Barton A. Kamen
Methotrexate metabolism.
Cancer chemotherapy and pharmacology 1983;10(3):230-1.
1982: Barton A. Kamen; J S Holcenberg; S E Siegel
Aziridinylbenzoquinone (AZQ) treatment of central nervous system leukemia.
Cancer treatment reports 1982;66(12):2105-6.
1982: G R Krakower; P A Nylen; Barton A. Kamen
Separation and identification of subpicomole amounts of methotrexate polyglutamates in animal and human biopsy material.
Analytical biochemistry 1982;122(2):412-6.
1982: T Ohnoshi; T Ohnuma; I Takahashi; K Scanlon; Barton A. Kamen; J F Holland
Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
Cancer research 1982;42(5):1655-60.
1981: Barton A. Kamen; P A Nylen; B M Camitta; J R Bertino
Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug.
British journal of haematology 1981;49(3):355-60.
1981: D I Scheer; S Srimatkandada; Barton A. Kamen; S Dube; Joseph R Bertino
Organization of the methotrexate resistant mouse L5178YR dihydrofolate reductase gene and transformation of human HCT-8 cells by this gene.
Haematology and blood transfusion 1981;26():171-4.
1981: D L Glaubiger; Daniel Von Hoff; J S Holcenberg; Barton A. Kamen; C Pratt; R S Ungerleider
The relative tolerance of children and adults to anticancer drugs.
Frontiers of radiation therapy and oncology 1981;16():42-9.
1980: Barton A. Kamen; C P Summers; H A Pearson
Exchange transfusion as a treatment for hyperleukocytosis, anemia, and metabolic abnormalities in a patient with leukemia.
The Journal of pediatrics 1980;96(6):1045-6.
1980: S Gross; Barton A. Kamen; A Fanaroff; D Caston
Folate compartments during gestational maturation.
The Journal of pediatrics 1980;96(5):842-4.
1980: Barton A. Kamen; A R Cashmore; R N Dreyer; B A Moroson; P Hsieh; J R Bertino
Effect of [3H]methotrexate impurities on apparent transport of methotrexate by a sensitive and resistant L1210 cell line.
The Journal of biological chemistry 1980;255(8):3254-7.
1980: Barton A. Kamen; J D Caston
Purification of folate binding factors.
Methods in enzymology 1980;66():678-86.
1980: Barton A. Kamen; J R Bertino
Folate and anti-folate transport in mammalian cells.
Antibiotics and chemotherapy 1980;28():62-7.
1976: Barton A. Kamen; P L Takach; R Vatev; J D Caston
A rapid, radiochemical-ligand binding assay for methotrexate.
Analytical biochemistry 1976;70(1):54-63.
1975: Barton A. Kamen; J D Caston
Purification of folate binding factor in normal umbilical cord serum.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(11):4261-4.
1975: Barton A. Kamen; J D Caston
Identification of a folate binder in hog kidney.
The Journal of biological chemistry 1975;250(6):2203-5.
1974: Barton A. Kamen; J D Caston
Direct radiochemical assay for serum folate: competition between 3H-folic acid and 5-methyltetrahydrofolic acid for a folate binder.
The Journal of laboratory and clinical medicine 1974;83(1):164-74.
1972: M DaCosta; S P Rothenberg; Barton A. Kamen
DNA synthesis in chronic myelogenous leukemia cells: comparison of results in cells containing folate binding factor to replicating cells without binder.
Blood 1972;39(5):621-7.
1969: S P Rothenberg; F Gizis; Barton A. Kamen
Antibodies against folic acid. I. In vitro biophysical effect.
The Journal of laboratory and clinical medicine 1969;74(4):662-71.