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Nicholas H. Oberlies

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TOP 3
Kathleen Köck; Nicholas H. Oberlies; Ying Xie; Roy L Hawke; Kim L R Brouwer
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
José G Napolitano; Nicholas H. Oberlies; Shao-Nong Chen; J Brent Friesen; Tyler N Graf; David C Lankin; James B McAlpine; Guido F Pauli
HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case.
Tamam El-Elimat; Mario Figueroa; Tyler N Graf; David J Kroll; Audrey F Adcock; Cynthia S Day; Cedric J Pearce; Huzefa A Raja; Mansukh C Wani; Nicholas H. Oberlies
Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).

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All Publications

2013: Kathleen Köck; Nicholas H. Oberlies; Ying Xie; Roy L Hawke; Kim L R Brouwer
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(5):958-65.
2013: José G Napolitano; Nicholas H. Oberlies; Shao-Nong Chen; J Brent Friesen; Tyler N Graf; David C Lankin; James B McAlpine; Guido F Pauli
HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case.
The Journal of organic chemistry 2013;78(7):2827-39.
2013: Tamam El-Elimat; Mario Figueroa; Tyler N Graf; David J Kroll; Audrey F Adcock; Cynthia S Day; Cedric J Pearce; Huzefa A Raja; Mansukh C Wani; Nicholas H. Oberlies
Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).
Journal of natural products 2013;76(3):382-7.
2013: Jessica R Bame; R Owen Bussey; Richard A Cech; Tamam El-Elimat; Joseph O Falkinham; Tyler N Graf; Scott A Jarmusch; Hiyas A Junio; Nicholas H. Oberlies; Nadja B Cech
Sarothrin from Alkanna orientalis is an antimicrobial agent and efflux pump inhibitor.
Planta medica 2013;79(5):327-9.
2013: Arlene A Sy-Cordero; Mansukh C Wani; Mary F Paine; Stephen J Polyak; Scott P Runyon; Rajesh Agarwal; Scott J Brantley; Tyler N Graf; David J Kroll; Nicholas H. Oberlies
Enhanced bioactivity of silybin B methylation products.
Bioorganic & medicinal chemistry 2013;21(3):742-7.
2013: Stephen J Polyak; Eve-Isabelle Pécheur; Harel Dahari; Peter Ferenci; Nicholas H. Oberlies; Jean-Michel Pawlotsky
Silymarin for HCV infection.
Antiviral therapy 2013;18(2):141-7.
2012: Arlene A Sy-Cordero; Cedric J Pearce; Nicholas H. Oberlies
Revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities.
The Journal of antibiotics 2012;65(11):541-9.
2012: Mario Figueroa; Tyler N Graf; David J Kroll; Ulyana Munoz-Acuna; Audrey F Adcock; Rajesh Agrawal; Sloan Ayers; Esperanza J Carcache de Blanco; Blaise A Darveaux; Cedric J Pearce; Steven M Swanson; Mansukh C Wani; Jilai Yang; Nicholas H. Oberlies
Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae.
The Journal of antibiotics 2012;65(11):559-64.
2012: Christina S Won; Nicholas H. Oberlies; Mary F Paine
Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.
Pharmacology & therapeutics 2012;136(2):186-201.
2012: Sloan Ayers; Esperanza J Carcache de Blanco; Brandie M Ehrmann; Joseph O Falkinham; David J Kroll; Sheila M Mitchell; Cedric J Pearce; Qi Shen; Steven M Swanson; Mansukh C Wani; Audrey F Adcock; Nicholas H. Oberlies
Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities.
Journal of peptide science : an official publication of the European Peptide Society 2012;18(8):500-10.
2012: Ulyana Muñoz Acuña; Sloan Ayers; Nicholas H. Oberlies; Cedric J Pearce; Jennifer Wittwer; Esperanza J Carcache DE Blanco
Effects of (5Z)-7-oxozeaenol on the oxidative pathway of cancer cells.
Anticancer research 2012;32(7):2665-71.
2012: Ulyana Muñoz Acuña; Sloan Ayers; Nicholas H. Oberlies; Cedric J Pearce; Jennifer Wittwer; Esperanza J Carcache DE Blanco
Effects of (5Z)-7-oxozeaenol on MDA-MB-231 breast cancer cells.
Anticancer research 2012;32(7):2415-21.
2012: Cedric J Pearce; Qi Shen; Djaja D Soejarto; Mansukh C Wani; Xiaoli Zhang; Esperanza J Carcache de Blanco; Norman R Farnsworth; James R Fuchs; David Jarjoura; A Douglas Kinghorn; David J Kroll; Daniel D Lantvit; Nicholas H. Oberlies; Jimmy Orjala; Steven M Swanson
Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi.
Methods in molecular biology (Clifton, N.J.) 2012;944():267-77.
2012: Gagan Deep; Subhash Chander Gangar; Mallikarjuna Gu; Nicholas H. Oberlies; Komal Raina; Subapriya Rajamanickam; Chapla Agarwal; Rajesh Agarwal
Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.
PloS one 2012;7(4):e34630.
2012: Sloan Ayers; Esperanza J Carcache de Blanco; Blaise A Darveaux; Tyler N Graf; David J Kroll; Susan Matthew; Cedric J Pearce; Qi Shen; Steven M Swanson; Mansukh C Wani; Audrey F Adcock; Nicholas H. Oberlies
Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022).
The Journal of antibiotics 2012;65(1):3-8.
2011: Arlene A Sy-Cordero; Mansukh C Wani; Cedric J Pearce; Qi Shen; Steven M Swanson; Audrey F Adcock; Tyler N Graf; David J Kroll; Nicholas H. Oberlies
Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).
Journal of natural products 2011;74(10):2137-42.
2011: Karen M VanderMolen; Cedric J Pearce; William McCulloch; Nicholas H. Oberlies
Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma.
The Journal of antibiotics 2011;64(8):525-31.
2011: Hiyas A Junio; Kathryn T Micko; Nicholas H. Oberlies; Scott J Richter; Arlene A Sy-Cordero; Johnna T Burns; Robert E Cannon; Keivan A Ettefagh; Tyler N Graf; Nadja B Cech
Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis).
Journal of natural products 2011;74(7):1621-9.
2011: Eunkyung Kim; Arlene Sy-Cordero; Tyler N Graf; Scott J Brantley; Mary F Paine; Nicholas H. Oberlies
Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes.
Planta medica 2011;77(3):265-70.
2010: Christina S Won; Nicholas H. Oberlies; Mary F Paine
Influence of dietary substances on intestinal drug metabolism and transport.
Current drug metabolism 2010;11(9):778-92.
2010: Arlene Sy-Cordero; Tyler N Graf; Yuka Nakanishi; Mansukh C Wani; Rajesh Agarwal; David Kroll; Nicholas H. Oberlies
Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.
Planta medica 2010;76(6):644-7.
2010: Feras Q Alali; Ahmad A Gharaibeh; Abdullah Ghawanmeh; Khaled Tawaha; Amjad Qandil; Jason P Burgess; Arlene Sy; Yuka Nakanishi; David Kroll; Nicholas H. Oberlies
Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae).
Natural product research 2010;24(2):152-9.
2009: Chen Li; Dongho Lee; Tyler N Graf; Sharnelle S Phifer; Yuka Nakanishi; Soedarsono Riswan; Fransisca M Setyowati; Achmad M Saribi; D Doel Soejarto; Norman R Farnsworth; Joseph O Falkinham; David Kroll; A Douglas Kinghorn; Mansukh C Wani; Nicholas H. Oberlies
Bioactive constituents of the stem bark of Mitrephora glabra.
Journal of natural products 2009;72(11):1949-53.
2009: Joseph O Falkinham; Thomas E Wall; Justin R Tanner; Khaled Tawaha; Feras Q Alali; Chen Li; Nicholas H. Oberlies
Proliferation of antibiotic-producing bacteria and concomitant antibiotic production as the basis for the antibiotic activity of Jordan's red soils.
Applied and environmental microbiology 2009;75(9):2735-41.
2009: Ngoc Ngo; Zhixia Yan; Tyler N Graf; Daniel R Carrizosa; Angela D M Kashuba; Elizabeth Dees; Nicholas H. Oberlies; Mary F Paine
Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):514-22.
2008: Gagan Deep; Komal Raina; Rana P Singh; Nicholas H. Oberlies; David J Kroll; Rajesh Agarwal
Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin.
International journal of cancer. Journal international du cancer 2008;123(12):2750-8.
2008: Feras Q Alali; Yahya R Tahboub; Eyad S Ibrahim; Amjad M Qandil; Khaled Tawaha; Jason P Burgess; arlene sy-cordero; Yuka Nakanishi; David J Kroll; Nicholas H. Oberlies
Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae).
Phytochemistry 2008;69(12):2341-6.
2008: Feras Q Alali; Ahmad Gharaibeh; Abdullah Ghawanmeh; Khaled Tawaha; Nicholas H. Oberlies
Colchicinoids from Colchicum crocifolium Boiss.: a case study in dereplication strategies for (-)-colchicine and related analogues using LC-MS and LC-PDA techniques.
Phytochemical analysis : PCA 2008;19(5):385-94.
2008: Gagan Deep; Nicholas H. Oberlies; David Kroll; Rajesh Agarwal
Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
International journal of cancer. Journal international du cancer 2008;123(1):41-50.
2008: Gagan Deep; Nicholas H. Oberlies; D J Kroll; Rajesh Agarwal
Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway.
Oncogene 2008;27(28):3986-98.
2008: Nicholas H. Oberlies; Chen Li; R J McGivney; Feras Q Alali; J R Tanner; Joseph O Falkinham
Microbial-mediated release of bisphenol A from polycarbonate vessels.
Letters in applied microbiology 2008;46(2):271-5.
2007: Tyler N Graf; Mansukh C Wani; Rajesh Agarwal; David Kroll; Nicholas H. Oberlies
Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention.
Planta medica 2007;73(14):1495-501.
2007: Feras Q Alali; Khaled Tawaha; Tamam El-Elimat; Maha Syouf; Mosa El-Fayad; Khaled Abulaila; Samara Joy Nielsen; William D Wheaton; Joseph O Falkinham; Nicholas H. Oberlies
Antioxidant activity and total phenolic content of aqueous and methanolic extracts of Jordanian plants: an ICBG project.
Natural product research 2007;21(12):1121-31.
2007: Tamara K Nun; David Kroll; Nicholas H. Oberlies; D Doel Soejarto; Ryan J Case; Pius Piskaut; Teatulohi Matainaho; Chelsey Hilscher; Ling Wang; Dirk P Dittmer; Shou-Jiang Gao; Blossom Damania
Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus.
Molecular cancer therapeutics 2007;6(8):2360-70.
2007: Gagan Deep; Nicholas H. Oberlies; David Kroll; Rajesh Agarwal
Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.
Carcinogenesis 2007;28(7):1533-42.
2007: Sharnelle S Phifer; Dongho Lee; Eun-Kyoung Seo; Nam-Cheol Kim; Tyler N Graf; David Kroll; Hernán A Navarro; Robert A Izydore; Francisco Jiménez; Ricardo Garcia; William C Rose; Craig R Fairchild; Robert Wild; D Doel Soejarto; Norman R Farnsworth; A Douglas Kinghorn; Nicholas H. Oberlies; Monroe E Wall; Mansukh C Wani
Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.
Journal of natural products 2007;70(6):954-61.
2007: David Kroll; Heather S Shaw; Nicholas H. Oberlies
Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies.
Integrative cancer therapies 2007;6(2):110-9.
2007: Tyler N Graf; Keith E Levine; Margaret E Andrews; Jason M Perlmutter; Samara Joy Nielsen; Jeanine M Davis; Mansukh C Wani; Nicholas H. Oberlies
Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).
Journal of agricultural and food chemistry 2007;55(4):1205-11.
2007: Mary F Paine; Nicholas H. Oberlies
Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions.
Expert opinion on drug metabolism & toxicology 2007;3(1):67-80.
2007: Dimitri Trembath; Anita Lal; David Kroll; Nicholas H. Oberlies; Gregory J Riggins
A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII.
Molecular cancer 2007;6():30.
2006: Meredith T Morgan; Yuka Nakanishi; David Kroll; Aaron P Griset; Michael A Carnahan; Michel Wathier; Nicholas H. Oberlies; Govindarajan Manikumar; Mansukh C Wani; Mark W Grinstaff
Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.
Cancer research 2006;66(24):11913-21.
2006: Feras Q Alali; Khaled Tawaha; Tamam El-Elimat; Rana M Qasaymeh; Chen Li; Jason Burgess; Yuka Nakanishi; David Kroll; Mansukh C Wani; Nicholas H. Oberlies
Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons.
Natural product research 2006;20(6):558-66.
2005: Chen Li; Nicholas H. Oberlies
The most widely recognized mushroom: chemistry of the genus Amanita.
Life sciences 2005;78(5):532-8.
2005: Chen Li; Dongho Lee; Tyler N Graf; Sharnelle S Phifer; Yuka Nakanishi; Jason P Burgess; Soedarsono Riswan; Fransisca M Setyowati; Achmad M Saribi; D Doel Soejarto; Norman R Farnsworth; Joseph O Falkinham; David Kroll; A Douglas Kinghorn; Mansukh C Wani; Nicholas H. Oberlies
A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.
Organic letters 2005;7(25):5709-12.
2005: Dongho Lee; Chen Li; Tyler N Graf; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Norman R Farnsworth; Patrick Jonas; A Douglas Kinghorn; David Kroll; Mansukh C Wani; Nicholas H. Oberlies
Diterpene glycosides from Egletes viscosa.
Planta medica 2005;71(8):792-4.
2005: Paula R Davis-Searles; Yuka Nakanishi; Nam-Cheol Kim; Tyler N Graf; Nicholas H. Oberlies; Mansukh C Wani; Monroe E Wall; Rajesh Agarwal; David Kroll
Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.
Cancer research 2005;65(10):4448-57.
2005: Feras Q Alali; Tamam El-Elimat; Chen Li; Amjad Qandil; Ahmad S Alkofahi; Khaled Tawaha; Jason P Burgess; Yuka Nakanishi; David Kroll; Hernán A Navarro; Joseph O Falkinham; Mansukh C Wani; Nicholas H. Oberlies
New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.
Journal of natural products 2005;68(2):173-8.
2004: Nicholas H. Oberlies; Nam-Cheol Kim; Dolores R Brine; Bradley J Collins; Robert W Handy; Charles M Sparacino; Mansukh C Wani; Monroe E Wall
Analysis of herbal teas made from the leaves of comfrey (Symphytum officinale): reduction of N-oxides results in order of magnitude increases in the measurable concentration of pyrrolizidine alkaloids.
Public health nutrition 2004;7(7):919-24.
2004: Jian-Qiao Gu; Tyler N Graf; Dongho Lee; Hee-Byung Chai; Qiuwen Mi; Leonardus B S Kardono; Fransisca M Setyowati; Rachman Ismail; Soedarsono Riswan; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; Steven M Swanson; David Kroll; Joseph O Falkinham; Monroe E Wall; Mansukh C Wani; A Douglas Kinghorn; Nicholas H. Oberlies
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
Journal of natural products 2004;67(7):1156-61.
2004: Nicholas H. Oberlies; David Kroll
Camptothecin and taxol: historic achievements in natural products research.
Journal of natural products 2004;67(2):129-35.
2003: Cody C Cain; Dongho Lee; Robert H Waldo; Alexis T Henry; Earl J Casida; Mansukh C Wani; Monroe E Wall; Nicholas H. Oberlies; Joseph O Falkinham
Synergistic antimicrobial activity of metabolites produced by a nonobligate bacterial predator.
Antimicrobial agents and chemotherapy 2003;47(7):2113-7.
2002: Nicholas H. Oberlies; Jason P Burgess; Hernán A Navarro; Rosa Elena Pinos; Craig R Fairchild; Russell W Peterson; D Doel Soejarto; Norman R Farnsworth; A Douglas Kinghorn; Mansukh C Wani; Monroe E Wall
Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.
Journal of natural products 2002;65(2):95-9.
2001: David Kroll; Heather S Shaw; M E Wall; Nicholas H. Oberlies
Variability in St. John's wort formulations is an important consideration.
Alternative therapies in health and medicine 2001;7(6):21-2.
2001: Nicholas H. Oberlies; Jason P Burgess; Hernán A Navarro; Rosa Elena Pinos; D Doel Soejarto; Norman R Farnsworth; A Douglas Kinghorn; Mansukh C Wani; Monroe E Wall
Bioactive constituents of the roots of Licania intrapetiolaris.
Journal of natural products 2001;64(4):497-501.
2001: Nam-Cheol Kim; Nicholas H. Oberlies; Dolores R Brine; R W Handy; Mansukh C Wani; Monroe E Wall
Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography.
Journal of natural products 2001;64(2):251-3.
1998: Nicholas H. Oberlies; LL Rogers; J M Martin; JL McLaughlin
Cytotoxic and insecticidal constituents of the unripe fruit of Persea americana.
Journal of natural products 1998;61(6):781-5.
1998: C S Packer; J E Roepke; Nicholas H. Oberlies; R A Rhoades
Myosin isoform shifts and decreased reactivity in hypoxia-induced hypertensive pulmonary arterial muscle.
The American journal of physiology 1998;274(5 Pt 1):L775-85.
1997: Nicholas H. Oberlies; C J Chang; JL McLaughlin
Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.
Journal of medicinal chemistry 1997;40(13):2102-6.
1997: Nicholas H. Oberlies; Vicki L Croy; Marietta L Harrison; JL McLaughlin
The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells.
Cancer letters 1997;115(1):73-9.
1996: L Zeng; F E Wu; Nicholas H. Oberlies; J L McLaughlin; S Sastrodihadjo
Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata.
Journal of natural products 1996;59(11):1035-42.
1996: L Zeng; Q Ye; Nicholas H. Oberlies; G Shi; Zhe-Ming Gu; K He; JL McLaughlin
Recent advances in Annonaceous acetogenins.
Natural product reports 1996;13(4):275-306.
1996: Q Ye; K He; Nicholas H. Oberlies; L Zeng; G Shi; D Evert; JL McLaughlin
Longimicins A-D: novel bioactive acetogenins from Asimina longifolia (annonaceae) and structure-activity relationships of asimicin type of annonaceous acetogenins.
Journal of medicinal chemistry 1996;39(9):1790-6.
1995: Nicholas H. Oberlies; J L Jones; Thomas H Corbett; S S Fotopoulos; JL McLaughlin
Tumor cell growth inhibition by several Annonaceous acetogenins in an in vitro disk diffusion assay.
Cancer letters 1995;96(1):55-62.
1995: D James Morré; Rafael de Cabo; C Farley; Nicholas H. Oberlies; JL McLaughlin
Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes.
Life sciences 1995;56(5):343-8.