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Angeline Bartholomeusz

Research Profile

Living Beings

Hepatitis B virus

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Physiology

Chemicals & Drugs

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Polymerase Chain Reaction

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Publications

TOP 3
Renae Walsh; Stewart Nuttall; Peter Revill; Danni Colledge; Liza Cabuang; Sally Soppe; Olan Dolezal; Kate Griffiths; Angeline Bartholomeusz; Stephen Locarnini
Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody.
J Audsley; N Arrifin; Lilly Yuen; A Ayres; S M Crowe; Angeline Bartholomeusz; S A Locarnini; Anne Mijch; S R Lewin; J Sasadeusz
Prolonged use of tenofovir in HIV/hepatitis B virus (HBV)-coinfected individuals does not lead to HBV polymerase mutations and is associated with persistence of lamivudine HBV polymerase mutations.
Joseph J Y Sung; Stephen K W Tsui; Chi-Hang Tse; Eddie Y T Ng; Kwok-Sui Leung; Kin-Hong Lee; Tony Shu Kam Mok; Angeline Bartholomeusz; Thomas C C Au; Kelvin K F Tsoi; Stephen Locarnini; Henry Lik-Yuen Chan
Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.

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All Publications

2011: Renae Walsh; Stewart Nuttall; Peter Revill; Danni Colledge; Liza Cabuang; Sally Soppe; Olan Dolezal; Kate Griffiths; Angeline Bartholomeusz; Stephen Locarnini
Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody.
Virology 2011;411(1):132-41.
2009: J Audsley; N Arrifin; Lilly Yuen; A Ayres; S M Crowe; Angeline Bartholomeusz; S A Locarnini; Anne Mijch; S R Lewin; J Sasadeusz
Prolonged use of tenofovir in HIV/hepatitis B virus (HBV)-coinfected individuals does not lead to HBV polymerase mutations and is associated with persistence of lamivudine HBV polymerase mutations.
HIV medicine 2009;10(4):229-35.
2008: Joseph J Y Sung; Stephen K W Tsui; Chi-Hang Tse; Eddie Y T Ng; Kwok-Sui Leung; Kin-Hong Lee; Tony Shu Kam Mok; Angeline Bartholomeusz; Thomas C C Au; Kelvin K F Tsoi; Stephen Locarnini; Henry Lik-Yuen Chan
Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.
Journal of virology 2008;82(7):3604-11.
2008: Christopher P Desmond; Angeline Bartholomeusz; Silvana Gaudieri; Peter Andrew Revill; Sharon R Lewin
A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics.
Antiviral therapy 2008;13(2):161-75.
2007: Julie Sheldon; Belen Ramos; Javier Garcia-Samaniego; Pilar Rios; Angeline Bartholomeusz; Miriam Romero; Stephen Locarnini; Fabien Zoulim; Vincent Soriano
Selection of hepatitis B virus (HBV) vaccine escape mutants in HBV-infected and HBV/HIV-coinfected patients failing antiretroviral drugs with anti-HBV activity.
Journal of acquired immune deficiency syndromes (1999) 2007;46(3):279-82.
2007: Peter Andrew Revill; Margaret Littlejohn; Anna Ayres; Lilly Yuen; Danni Colledge; Angeline Bartholomeusz; Joe Sasaduesz; Sharon R Lewin; Gregory J Dore; Gail V Matthews; Chloe L Thio; Stephen A Locarnini
Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individuals.
AIDS (London, England) 2007;21(13):1701-10.
2007: Alexander J V Thompson; Anna Ayres; Lilly Yuen; Angeline Bartholomeusz; D Scott Bowden; David M Iser; Robert Y M Chen; Barbara Demediuk; Gideon Shaw; Sally J Bell; Katrina J R Watson; Stephen A Locarnini; Paul V Desmond
Lamivudine resistance in patients with chronic hepatitis B: role of clinical and virological factors.
Journal of gastroenterology and hepatology 2007;22(7):1078-85.
2007: Anna S F Lok; Fabien Zoulim; Stephen Locarnini; Angeline Bartholomeusz; Marc G Ghany; Jean-Michel Pawlotsky; Yun-Fan Liaw; Masashi Mizokami; Carla Kuiken
Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management.
Hepatology (Baltimore, Md.) 2007;46(1):254-65.
2007: Nadia Warner; Stephen Locarnini; Michael Kuiper; Angeline Bartholomeusz; Anna Ayres; Lilly Yuen; Tim Shaw
The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro.
Antimicrobial agents and chemotherapy 2007;51(7):2285-92.
2007: Lilly Yuen; Anna Ayres; Margaret Littlejohn; Danni Colledge; Andrew Edgely; William J Maskill; Stephen A Locarnini; Angeline Bartholomeusz
SeqHepB: a sequence analysis program and relational database system for chronic hepatitis B.
Antiviral research 2007;75(1):64-74.
2006: Camille Szmaragd; G R Foster; Andrea Manica; Angeline Bartholomeusz; Richard A Nichols; François Balloux
Genome-wide characterisation of hepatitis B mutations involved in clinical outcome.
Heredity 2006;97(6):389-97.
2006: Julie Sheldon; B Rodès; Fabien Zoulim; Angeline Bartholomeusz; Vincent Soriano
Mutations affecting the replication capacity of the hepatitis B virus.
Journal of viral hepatitis 2006;13(7):427-34.
2006: Angeline Bartholomeusz; Stephen A Locarnini
Antiviral drug resistance: clinical consequences and molecular aspects.
Seminars in liver disease 2006;26(2):162-70.
2006: Gail V Matthews; Angeline Bartholomeusz; Stephen Locarnini; Anna Ayres; Joe Sasaduesz; Eric C Seaberg; David A Cooper; Sharon Lewin; Gregory J Dore; Chloe L Thio
Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy.
AIDS (London, England) 2006;20(6):863-70.
2006: Tim Shaw; Angeline Bartholomeusz; Stephen Locarnini
HBV drug resistance: mechanisms, detection and interpretation.
Journal of hepatology 2006;44(3):593-606.
2006: Angeline Bartholomeusz; S Locarnini
Hepatitis B virus mutations associated with antiviral therapy.
Journal of medical virology 2006;78 Suppl 1():S52-5.
2005: Henry Lik-Yuen Chan; Stephen Kwok-Wing Tsui; Chi-Hang Tse; Eddie Y T Ng; Thomas C C Au; Lilly Yuen; Angeline Bartholomeusz; Kwok-Sui Leung; Kin-Hong Lee; Stephen Locarnini; Joseph J Y Sung
Epidemiological and virological characteristics of 2 subgroups of hepatitis B virus genotype C.
The Journal of infectious diseases 2005;191(12):2022-32.
2005: P T K Vietheer; H J Netter; T Sozzi; Angeline Bartholomeusz
Failure of the lamivudine-resistant rtM204I hepatitis B virus mutants to efficiently support hepatitis delta virus secretion.
Journal of virology 2005;79(10):6570-3.
2005: varsha thakur; Syed N Kazim; Rajkumar C Guptan; Seyed E Hasnain; Angeline Bartholomeusz; Veena Malhotra; Shiv K Sarin
Transmission of G145R mutant of HBV to an unrelated contact.
Journal of medical virology 2005;76(1):40-6.
2005: J Judy Chang; Fiona Wightman; Angeline Bartholomeusz; Anna Ayres; Stephen J Kent; Joseph Sasadeusz; Sharon R Lewin
Reduced hepatitis B virus (HBV)-specific CD4+ T-cell responses in human immunodeficiency virus type 1-HBV-coinfected individuals receiving HBV-active antiretroviral therapy.
Journal of virology 2005;79(5):3038-51.
2005: Chee-Kin Hui; John Yu; Wing Y Au; Hai-ying Zhang; Angeline Bartholomeusz; Stephen Locarnini; Yok-Lam Kwong; Raymond Liang; George K K Lau
Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2005;32(2):173-8.
2005: Sally J Bell; A Lau; A Thompson; Katrina J R Watson; B Demediuk; G Shaw; Robert Y M Chen; Anna Ayres; Lilly Yuen; Angeline Bartholomeusz; Stephen A Locarnini; Paul V Desmond
Chronic hepatitis B: recommendations for therapy based on the natural history of disease in Australian patients.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2005;32(2):122-7.
2005: Julie Sheldon; Nuria Camino; Berta Rodés; Angeline Bartholomeusz; Michael Kuiper; Frank Tacke; Marina Núñez; Stefan Mauss; Thomas Lutz; Gerd Klausen; Stephen Locarnini; Vincent Soriano
Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir.
Antiviral therapy 2005;10(6):727-34.
2004: Daniel J Tenney; Steven M Levine; Ronald E Rose; Ann W Walsh; Steve Weinheimer; Linda F Discotto; Mary Jane Plym; Kevin A Pokornowski; Cheng-Fang Yu; Peter W Angus; Anna Ayres; Angeline Bartholomeusz; William Sievert; G Thompson; Nadia Warner; Stephen Locarnini; Richard J Colonno
Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.
Antimicrobial agents and chemotherapy 2004;48(9):3498-507.
2004: Fiona Wightman; Tomos Walters; Anna Ayres; Scott Bowden; Angeline Bartholomeusz; Daryl Lau; Stephen Locarnini; Sharon R Lewin
Comparison of sequence analysis and a novel discriminatory real-time PCR assay for detection and quantification of Lamivudine-resistant hepatitis B virus strains.
Journal of clinical microbiology 2004;42(8):3809-12.
2004: Angeline Bartholomeusz; Benjamin G Tehan; David K Chalmers
Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations.
Antiviral therapy 2004;9(2):149-60.
2004: Anna Ayres; Stephen Locarnini; Angeline Bartholomeusz
HBV genotyping and analysis for unique mutations.
Methods in molecular medicine 2004;95():125-49.
2004: Angeline Bartholomeusz; Stephan Schaefer
Hepatitis B virus genotypes: comparison of genotyping methods.
Reviews in medical virology 2004;14(1):3-16.
2003: Peter W Angus; Rhys Vaughan; Shelly Xiong; Huiling Yang; William E Delaney; Craig Gibbs; Carol L Brosgart; Danni Colledge; Rosalind Edwards; Anna Ayres; Angeline Bartholomeusz; Stephen Locarnini
Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase.
Gastroenterology 2003;125(2):292-7.
2003: Louise Cooley; Anna Ayres; Angeline Bartholomeusz; Sharon Lewin; Suzanne Crowe; Anne Mijch; Stephen Locarnini; Joseph Sasadeusz
Prevalence and characterization of lamivudine-resistant hepatitis B virus mutations in HIV-HBV co-infected individuals.
AIDS (London, England) 2003;17(11):1649-57.
2003: Anna Ayres; Angeline Bartholomeusz; George Lau; Kui-Chan Lam; Jia-Yee Lee; Stephen Locarnini
Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2003;27(1):111-6.
2003: Scott Bowden; Angeline Bartholomeusz; Stephen Locarnini
Lamivudine resistant occult HBV: implications for public health?
Journal of hepatology 2003;38(4):526-8.
2003: Stephen Locarnini; Janine McMillan; Angeline Bartholomeusz
The hepatitis B virus and common mutants.
Seminars in liver disease 2003;23(1):5-20.
2002: George K K Lau; Ming-Liang He; Daniel Y T Fong; Angeline Bartholomeusz; Wing Y Au; A K W Lie; Stephen Locarnini; Raymond Liang
Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation.
Hepatology (Baltimore, Md.) 2002;36(3):702-9.
2002: Stephen A Locarnini; Angeline Bartholomeusz
Advances in hepatitis C: what is coming in the next 5 years?
Journal of gastroenterology and hepatology 2002;17(4):442-7.
2002: William E Delaney; Angeline Bartholomeusz; Stephen A Locarnini
Evolving therapies for the treatment of chronic hepatitis B virus infection.
Expert opinion on investigational drugs 2002;11(2):169-87.
2001: Angeline Bartholomeusz; S Locarnini
Hepatitis B virus mutants and fulminant hepatitis B: fitness plus phenotype.
Hepatology (Baltimore, Md.) 2001;34(2):432-5.
1999: Geoffrey W McCaughan; J Spencer; David Koorey; Scott Bowden; Angeline Bartholomeusz; Margaret Littlejohn; Deborah Verran; A K K Chui; A G R Sheil; R M Jones; Stephen A Locarnini; Peter W Angus
Lamivudine therapy in patients undergoing liver transplantation for hepatitis B virus precore mutant-associated infection: high resistance rates in treatment of recurrence but universal prevention if used as prophylaxis with very low dose hepatitis B immune globulin.
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 1999;5(6):512-9.
1999: Angeline Bartholomeusz; P Thompson
Flaviviridae polymerase and RNA replication.
Journal of viral hepatitis 1999;6(4):261-70.
1998: Robert A de Man; Angeline Bartholomeusz; Hubert G M Niesters; pieter zondervan; S A Locarnini
The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss.
Journal of hepatology 1998;29(4):669-75.
1998: Margaret Littlejohn; Stephen Locarnini; Angeline Bartholomeusz
Targets for inhibition of hepatitis C virus replication.
Antiviral therapy 1998;3(Suppl 3):83-91.
1997: T T Aye; Angeline Bartholomeusz; Tim Shaw; Scott Bowden; Alan M Breschkin; J McMillan; Peter W Angus; Stephen Locarnini
Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation.
Journal of hepatology 1997;26(5):1148-53.
1997: Angeline Bartholomeusz; L C Groenen; Stephen A Locarnini
Clinical experience with famciclovir against hepatitis B virus.
Intervirology 1997;40(5-6):337-42.
1994: Angeline Bartholomeusz; E Tomlinson; Peter J Wright; C Birch; S Locarnini; H Weigold; S Marcuccio; George Holan
Use of a flavivirus RNA-dependent RNA polymerase assay to investigate the antiviral activity of selected compounds.
Antiviral research 1994;24(4):341-50.
1993: Angeline Bartholomeusz; Peter J Wright
Synthesis of dengue virus RNA in vitro: initiation and the involvement of proteins NS3 and NS5.
Archives of virology 1993;128(1-2):111-21.
1987: A Biedrzycka; M R Cauchi; Angeline Bartholomeusz; J J Gorman; Peter J Wright
Characterization of protease cleavage sites involved in the formation of the envelope glycoprotein and three non-structural proteins of dengue virus type 2, New Guinea C strain.
The Journal of general virology 1987;68 ( Pt 5)():1317-26.