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Charles H. Spruck

Research Profile

Physiology

Chemicals & Drugs

Disorders

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Sheep

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Molecular Sequence Data

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Publications

TOP 3
Vasco Liberal; Hanna-Stina Martinsson-Ahlzén; Clare H McGowan; Charles H. Spruck; Martin Widschwendter; Jennifer Liberal; Steven I Reed
Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins.
Ajay A Vashisht; Kimberly B Zumbrennen; Xinhua Huang; David N Powers; Armando Durazo; Dahui Sun; Nimesh Bhaskaran; Anja Persson; Mathias Uhlen; Olle Sangfelt; Charles H. Spruck; Elizabeth A Leibold; James Wohlschlegel
Control of iron homeostasis by an iron-regulated ubiquitin ligase.
Kathleen Klotz; Diana Cepeda; Yingmeei Tan; Dahui Sun; Olle Sangfelt; Charles H. Spruck
SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis.

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All Publications

2012: Vasco Liberal; Hanna-Stina Martinsson-Ahlzén; Clare H McGowan; Charles H. Spruck; Martin Widschwendter; Jennifer Liberal; Steven I Reed
Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2754-9.
2009: Ajay A Vashisht; Kimberly B Zumbrennen; Xinhua Huang; David N Powers; Armando Durazo; Dahui Sun; Nimesh Bhaskaran; Anja Persson; Mathias Uhlen; Olle Sangfelt; Charles H. Spruck; Elizabeth A Leibold; James Wohlschlegel
Control of iron homeostasis by an iron-regulated ubiquitin ligase.
Science (New York, N.Y.) 2009;326(5953):718-21.
2009: Kathleen Klotz; Diana Cepeda; Yingmeei Tan; Dahui Sun; Olle Sangfelt; Charles H. Spruck
SCF(Fbxw7/hCdc4) targets cyclin E2 for ubiquitin-dependent proteolysis.
Experimental cell research 2009;315(11):1832-9.
2008: YingMeei Tan; Olle Sangfelt; Charles H. Spruck
The Fbxw7/hCdc4 tumor suppressor in human cancer.
Cancer letters 2008;271(1):1-12.
2008: Hanna-Stina Martinsson-Ahlzén; Vasco Liberal; Björn Grünenfelder; Susana R Chaves; Charles H. Spruck; Steven I Reed
Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.
Molecular and cellular biology 2008;28(18):5698-709.
2007: Shahab Akhoondi; Dahui Sun; Natalie von der Lehr; Sophia Apostolidou; Kathleen Klotz; Alena Maljukova; Diana Cepeda; Heidi Fiegl; Dimitra Dafou; Dimitra Dofou; Christian Marth; Elisabeth Mueller-Holzner; Martin Corcoran; Markus Dagnell; Sepideh Zabihi Nejad; Babak Noori Nayer; Mohammad Reza Zali; Johan Hansson; Suzanne Egyhazi; Fredrik Petersson; Per Sangfelt; Hans Nordgren; Dan Grander; Steven I Reed; Martin Widschwendter; Olle Sangfelt; Charles H. Spruck
FBXW7/hCDC4 is a general tumor suppressor in human cancer.
Cancer research 2007;67(19):9006-12.
2007: Alena Malyukova; Takeaki Dohda; Natalie von der Lehr; Shahab Akhoondi; Shahab Akhondi; Martin Corcoran; Mats Heyman; Charles H. Spruck; Dan Grandér; Urban Lendahl; Olle Sangfelt
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.
Cancer research 2007;67(12):5611-6.
2007: Ulrich B Keller; Jennifer B Old; Frank C Dorsey; Jonas A Nilsson; Lisa Nilsson; Kirsteen H Maclean; Linda Chung; Chunying Yang; Charles H. Spruck; Kelli Boyd; Steven I Reed; John L Cleveland
Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis.
The EMBO journal 2007;26(10):2562-74.
2006: Charles H. Spruck; Dahui Sun; Heidi Fiegl; Christian Marth; Elisabeth Mueller-Holzner; Georg Goebel; Martin Widschwendter; Steven I Reed
Detection of low molecular weight derivatives of cyclin E1 is a function of cyclin E1 protein levels in breast cancer.
Cancer research 2006;66(14):7355-60.
2004: Michael Hubalek; Andreas Widschwendter; Martin Erdel; Andreas Gschwendtner; Heidi Fiegl; Hannes M Müller; Georg Goebel; Elisabeth Mueller-Holzner; Christian Marth; Charles H. Spruck; Steven I Reed; Martin Widschwendter
Cyclin E dysregulation and chromosomal instability in endometrial cancer.
Oncogene 2004;23(23):4187-92.
2004: Susanna Ekholm-Reed; Charles H. Spruck; Olle Sangfelt; Frank van Drogen; Elisabeth Mueller-Holzner; Martin Widschwendter; Anders Zetterberg; Steven I Reed; Susanna Ekholm Reed
Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer.
Cancer research 2004;64(3):795-800.
2003: Charles H. Spruck; Maria P de Miguel; Adrian P L Smith; Aimee Ryan; Paula Stein; Richard M Schultz; A Jeannine Lincoln; Peter J Donovan; Steven I Reed
Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis.
Science (New York, N.Y.) 2003;300(5619):647-50.
2002: Charles H. Spruck; Heimo M Strohmaier; Olle Sangfelt; Hannes M Müller; Michael Hubalek; Elisabeth Müller-Holzner; Christian Marth; Martin Widschwendter; Steven I Reed
hCDC4 gene mutations in endometrial cancer.
Cancer research 2002;62(16):4535-9.
2002: Charles H. Spruck; Heimo M Strohmaier
Seek and destroy: SCF ubiquitin ligases in mammalian cell cycle control.
Cell cycle (Georgetown, Tex.) 2002;1(4):250-4.
2001: Heimo M Strohmaier; Charles H. Spruck; Peter Kaiser; KA Won; Olle Sangfelt; Steven I Reed
Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.
Nature 2001;413(6853):316-22.
2001: Charles H. Spruck; Heimo M Strohmaier; M Watson; Adrian P L Smith; A Ryan; T W Krek; Steven I Reed
A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
Molecular cell 2001;7(3):639-50.
1999: Charles H. Spruck; KA Won; Steven I Reed
Deregulated cyclin E induces chromosome instability.
Nature 1999;401(6750):297-300.
1998: parkash Gill; Y C Tsai; A P Rao; Charles H. Spruck; T Zheng; W A Harrington; T Cheung; Bharat N Nathwani; Peter A Jones
Evidence for multiclonality in multicentric Kaposi's sarcoma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8257-61.
1997: Jan M. Van Tornout; Charles H. Spruck; A Shibata; C Schmutte; M Gonzalez-Zulueta; Peter W Nichols; P T Chandrasoma; Mimi C Yu; Peter A Jones
Presence of p53 mutations in primary nasopharyngeal carcinoma (NPC) in non-Asians of Los Angeles, California, a low-risk population for NPC.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1997;6(7):493-7.
1997: Mark L Gonzalgo; Gangning Liang; Charles H. Spruck; J M Zingg; W M Rideout; Peter A Jones
Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR.
Cancer research 1997;57(4):594-9.
1996: A R Simoneau; Charles H. Spruck; M Gonzalez-Zulueta; Mark L Gonzalgo; M F Chan; Yvonne C Tsai; M Dean; Kenneth Steven; T Horn; Peter A Jones
Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations.
Cancer research 1996;56(21):5039-43.
1995: M Gonzalez-Zulueta; A Shibata; P F Ohneseit; Charles H. Spruck; C Busch; M Shamaa; Mahmoud El-Baz; Peter W Nichols; Mark L Gonzalgo; M ] Elbaz M [corrected to El-Baz
High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder.
Journal of the National Cancer Institute 1995;87(18):1383-93.
1995: Yvonne C Tsai; A R Simoneau; Charles H. Spruck; Peter W Nichols; Kenneth Steven; J D Buckley; Peter A Jones
Mosaicism in human epithelium: macroscopic monoclonal patches cover the urothelium.
The Journal of urology 1995;153(5):1697-700.
1994: W M Rideout; P Eversole-Cire; Charles H. Spruck; C M Hustad; Gerhard A Coetzee; Felicidad A Gonzales; Peter A Jones
Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation.
Molecular and cellular biology 1994;14(9):6143-52.
1994: Charles H. Spruck; M Gonzalez-Zulueta; A Shibata; A R Simoneau; M F Lin; Felicidad A Gonzales; Yvonne C Tsai; Peter A Jones
p16 gene in uncultured tumours.
Nature 1994;370(6486):183-4.
1994: A Shibata; P F Ohneseit; Yvonne C Tsai; Charles H. Spruck; Peter W Nichols; H S Chiang; M K Lai; Peter A Jones
Mutational spectrum in the p53 gene in bladder tumors from the endemic area of black foot disease in Taiwan.
Carcinogenesis 1994;15(6):1085-7.
1994: Charles H. Spruck; P F Ohneseit; M Gonzalez-Zulueta; D Esrig; N Miyao; Yvonne C Tsai; S P Lerner; C Schmütte; A S Yang; Richard J Cote
Two molecular pathways to transitional cell carcinoma of the bladder.
Cancer research 1994;54(3):784-8.
1993: M Gonzalez-Zulueta; J M Ruppert; K Tokino; Yvonne C Tsai; Charles H. Spruck; N Miyao; Peter W Nichols; G G Hermann; T Horn; Kenneth Steven
Microsatellite instability in bladder cancer.
Cancer research 1993;53(23):5620-3.
1993: D Esrig; Charles H. Spruck; Peter W Nichols; Benjaporn Chaiwun; Kenneth Steven; Susan Groshen; S C Chen; Donald G Skinner; Peter A Jones; Richard J Cote
p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer.
The American journal of pathology 1993;143(5):1389-97.
1993: N Miyao; Yvonne C Tsai; S P Lerner; A F Olumi; Charles H. Spruck; M Gonzalez-Zulueta; Peter W Nichols; Donald G Skinner; Peter A Jones
Role of chromosome 9 in human bladder cancer.
Cancer research 1993;53(17):4066-70.
1993: Charles H. Spruck; W M Rideout; A F Olumi; P F Ohneseit; A S Yang; Yvonne C Tsai; Peter W Nichols; T Horn; G G Hermann; Kenneth Steven
Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage.
Cancer research 1993;53(5):1162-6.
1993: Charles H. Spruck; W M Rideout; Peter A Jones
DNA methylation and cancer.
EXS 1993;64():487-509.
1992: Charles H. Spruck; Yvonne C Tsai; D P Huang; A S Yang; W M Rideout; M Gonzalez-Zulueta; P Choi; K W Lo; Mimi C Yu; Peter A Jones
Absence of p53 gene mutations in primary nasopharyngeal carcinomas.
Cancer research 1992;52(17):4787-90.
1992: Darryl Shibata; Debra Hawes; Z H Li; Antonio M Hernandez; Charles H. Spruck; Peter W Nichols
Specific genetic analysis of microscopic tissue after selective ultraviolet radiation fractionation and the polymerase chain reaction.
The American journal of pathology 1992;141(3):539-43.
1992: Peter A Jones; W M Rideout; J C Shen; Charles H. Spruck; Yvonne C Tsai
Methylation, mutation and cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(1):33-6.
1991: W M Rideout; Gerhard A Coetzee; A F Olumi; Charles H. Spruck; Peter A Jones
5-Methylcytosine as an endogenous mutagen in the p53 tumor suppressor gene.
Princess Takamatsu symposia 1991;22():207-19.
1990: T C Moore; Charles H. Spruck; J L Lami; A Ghaly; M Totz; S I Said
Depression of peripheral lymph node lymphocyte traffic in sheep following central venous allogeneic whole-blood transfusion.
Transplantation 1990;49(4):838-43.
1989: T C Moore; J L Lami; Charles H. Spruck
Substance P increases lymphocyte traffic and lymph flow through peripheral lymph nodes of sheep.
Immunology 1989;67(1):109-14.
1989: T C Moore; Charles H. Spruck; J L Lami; S I Said
Prompt elevations of PGE2 and thromboxane A2 metabolites in peripheral node efferent lymph of sheep following drainage area immunization.
Immunopharmacology 1989;17(2):73-80.
1988: Charles H. Spruck; T C Moore
Anesthesia-associated depression of peripheral node lymphocyte traffic and antibody production in sheep accompanied by elevations in arachidonic acid metabolites in efferent lymph.
Transplantation proceedings 1988;20(6):1169-74.
1988: T C Moore; Charles H. Spruck; S I Said
In vivo depression of lymphocyte traffic in sheep by VIP and HIV (AIDS)-related peptides.
Immunopharmacology 1988;16(3):181-9.
1988: T C Moore; Charles H. Spruck; S I Said
Depression of lymphocyte traffic in sheep by vasoactive intestinal peptide (VIP).
Immunology 1988;64(3):475-8.
1988: T C Moore; Charles H. Spruck; L E Leduc
Depression of lymphocyte traffic in sheep by anaesthesia and associated changes in efferent-lymph PGE2 and antibody levels.
Immunology 1988;63(1):139-43.
1987: T C Moore; M Lippmann; Charles H. Spruck; R Gamal
Increased outputs of lymphocytes in lymph efferent from the lymph nodes of sheep during systemic arterial hypertension induced by phenylephrine or dopamine.
Immunopharmacology 1987;14(3):151-7.