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William M. Sugden

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Zachary L Pratt; Malika Kuzembayeva; Srikumar Sengupta; William M. Sugden
The microRNAs of Epstein-Barr Virus are expressed at dramatically differing levels among cell lines.
Lindsay R Dresang; David T Vereide; William M. Sugden
Identifying sites bound by Epstein-Barr virus nuclear antigen 1 (EBNA1) in the human genome: defining a position-weighted matrix to predict sites bound by EBNA1 in viral genomes.
Dong Yun Lee; Jisook Lee; William M. Sugden
The unfolded protein response and autophagy: herpesviruses rule!

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All Publications

2009: Zachary L Pratt; Malika Kuzembayeva; Srikumar Sengupta; William M. Sugden
The microRNAs of Epstein-Barr Virus are expressed at dramatically differing levels among cell lines.
Virology 2009;386(2):387-97.
2009: Lindsay R Dresang; David T Vereide; William M. Sugden
Identifying sites bound by Epstein-Barr virus nuclear antigen 1 (EBNA1) in the human genome: defining a position-weighted matrix to predict sites bound by EBNA1 in viral genomes.
Journal of virology 2009;83(7):2930-40.
2009: Dong Yun Lee; Jisook Lee; William M. Sugden
The unfolded protein response and autophagy: herpesviruses rule!
Journal of virology 2009;83(3):1168-72.
2008: Amanda A Mack; William M. Sugden
EBV is necessary for proliferation of dually infected primary effusion lymphoma cells.
Cancer research 2008;68(17):6963-8.
2008: Chen-Yu Wang; William M. Sugden
Identifying a property of origins of DNA synthesis required to support plasmids stably in human cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9639-44.
2008: Scott E Lindner; Krisztina Zeller; Aloys Schepers; William M. Sugden
The affinity of EBNA1 for its origin of DNA synthesis is a determinant of the origin's replicative efficiency.
Journal of virology 2008;82(12):5693-702.
2008: D Y Lee; William M. Sugden
The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy.
Oncogene 2008;27(20):2833-42.
2008: Srikumar Sengupta; Johan A den Boon; I-How Chen; Michael A Newton; Stephen A Stanhope; Yu-Juen Cheng; Chien-Jen Chen; Allan Hildesheim; William M. Sugden; Paul Ahlquist
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(15):5874-8.
2008: Dong Yun Lee; William M. Sugden
The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis.
Blood 2008;111(4):2280-9.
2007: Asuka Nanbo; Arthur Sugden; William M. Sugden
The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cells.
The EMBO journal 2007;26(19):4252-62.
2007: Jisook Lee; William M. Sugden
A membrane leucine heptad contributes to trafficking, signaling, and transformation by latent membrane protein 1.
Journal of virology 2007;81(17):9121-30.
2007: Scott E Lindner; William M. Sugden
The plasmid replicon of Epstein-Barr virus: mechanistic insights into efficient, licensed, extrachromosomal replication in human cells.
Plasmid 2007;58(1):1-12.
2006: Markus Altmann; Dagmar Pich; Romana Ruiss; Jindong Wang; William M. Sugden; Wolfgang Hammerschmidt
Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):14188-93.
2006: Srikumar Sengupta; Johan A den Boon; I-How Chen; Michael A Newton; David B Dahl; Meng Chen; Yu-Juen Cheng; William H Westra; Chien-Jen Chen; Allan Hildesheim; William M. Sugden; Paul Ahlquist
Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma.
Cancer research 2006;66(16):7999-8006.
2006: William M. Sugden
Virology: micro mystery solution.
Nature 2006;442(7098):33-4.
2006: Jindong Wang; Scott E Lindner; Elizabeth R Leight; William M. Sugden
Essential elements of a licensed, mammalian plasmid origin of DNA synthesis.
Molecular and cellular biology 2006;26(3):1124-34.
2005: Jacqueline G Perrigoue; Johan A den Boon; Andreas Friedl; Michael A Newton; Paul Ahlquist; William M. Sugden
Lack of association between EBV and breast carcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(4):809-14.
2005: Ulrike Dirmeier; Reinhard Hoffmann; Ellen Kilger; Ute Schultheiss; Cinthia Briseño; Olivier Gires; Arnd Kieser; Dirk Eick; William M. Sugden; Wolfgang Hammerschmidt
Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis.
Oncogene 2005;24(10):1711-7.
2005: Jindong Wang; William M. Sugden
Origins of bidirectional replication of Epstein-Barr virus: models for understanding mammalian origins of DNA synthesis.
Journal of cellular biochemistry 2005;94(2):247-56.
2004: Wolfgang Hammerschmidt; William M. Sugden
Epstein-Barr virus sustains Burkitt's lymphomas and Hodgkin's disease.
Trends in molecular medicine 2004;10(7):331-6.
2004: Ngan Lam; Mark L Sandberg; William M. Sugden
High physiological levels of LMP1 result in phosphorylation of eIF2 alpha in Epstein-Barr virus-infected cells.
Journal of virology 2004;78(4):1657-64.
2004: Chen-Yu Wang; William M. Sugden
New viruses shake old paradigms.
The Journal of clinical investigation 2004;113(1):21-3.
2003: Gregory Kennedy; Jun Komano; William M. Sugden
Epstein-Barr virus provides a survival factor to Burkitt's lymphomas.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14269-74.
2003: Gregory Kennedy; William M. Sugden
EBNA-1, a bifunctional transcriptional activator.
Molecular and cellular biology 2003;23(19):6901-8.
2003: Ngan Lam; William M. Sugden
LMP1, a viral relative of the TNF receptor family, signals principally from intracellular compartments.
The EMBO journal 2003;22(12):3027-38.
2003: Ngan Lam; William M. Sugden
CD40 and its viral mimic, LMP1: similar means to different ends.
Cellular signalling 2003;15(1):9-16.
2002: Ajamete Kaykas; Kathleen Worringer; William M. Sugden
LMP-1's transmembrane domains encode multiple functions required for LMP-1's efficient signaling.
Journal of virology 2002;76(22):11551-60.
2002: William M. Sugden
In the beginning: a viral origin exploits the cell.
Trends in biochemical sciences 2002;27(1):1-3.
2001: William M. Sugden; K Takada
Epstein-Barr virus and human cancer: Hokkaido University, July 4-6, 2001.
Japanese journal of cancer research : Gann 2001;92(12):1352-4.
2001: Elizabeth R Leight; William M. Sugden; E R Light
The cis-acting family of repeats can inhibit as well as stimulate establishment of an oriP replicon.
Journal of virology 2001;75(22):10709-20.
2001: Elizabeth R Leight; William M. Sugden
Establishment of an oriP replicon is dependent upon an infrequent, epigenetic event.
Molecular and cellular biology 2001;21(13):4149-61.
2001: Ajamete Kaykas; K Worringer; William M. Sugden
CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complex.
The EMBO journal 2001;20(11):2641-54.
2001: William M. Sugden; Elizabeth R Leight
EBV's plasmid replicon: an enigma in cis and trans.
Current topics in microbiology and immunology 2001;258():3-11.
2000: M L Sandberg; Ajamete Kaykas; William M. Sugden
Latent membrane protein 1 of Epstein-Barr virus inhibits as well as stimulates gene expression.
Journal of virology 2000;74(20):9755-61.
2000: Ajamete Kaykas; William M. Sugden
The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferation.
Oncogene 2000;19(11):1400-10.
2000: Elizabeth R Leight; William M. Sugden
EBNA-1: a protein pivotal to latent infection by Epstein-Barr virus.
Reviews in medical virology 2000;10(2):83-100.
1999: T Bloss; Ajamete Kaykas; William M. Sugden
Dissociation of patching by latent membrane protein-1 of Epstein-Barr virus from its stimulation of NF-kappaB activity.
The Journal of general virology 1999;80 ( Pt 12)():3227-32.
1999: D Mackey; William M. Sugden
The linking regions of EBNA1 are essential for its support of replication and transcription.
Molecular and cellular biology 1999;19(5):3349-59.
1999: D Mackey; William M. Sugden
Applications of oriP plasmids and their mode of replication.
Methods in enzymology 1999;306():308-28.
1998: Ashok Aiyar; William M. Sugden
Fusions between Epstein-Barr viral nuclear antigen-1 of Epstein-Barr virus and the large T-antigen of simian virus 40 replicate their cognate origins.
The Journal of biological chemistry 1998;273(49):33073-81.
1998: Ashok Aiyar; Curtis Tyree; William M. Sugden
The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a viral maintenance element.
The EMBO journal 1998;17(21):6394-403.
1998: Ann L Kirchmaier; William M. Sugden
Rep*: a viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus.
Journal of virology 1998;72(6):4657-66.
1997: D Mackey; William M. Sugden
Studies on the mechanism of DNA linking by Epstein-Barr virus nuclear antigen 1.
The Journal of biological chemistry 1997;272(47):29873-9.
1997: M Sandberg; Wolfgang Hammerschmidt; William M. Sugden
Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.
Journal of virology 1997;71(6):4649-56.
1997: Ann L Kirchmaier; William M. Sugden
Dominant-negative inhibitors of EBNA-1 of Epstein-Barr virus.
Journal of virology 1997;71(3):1766-75.
1995: D Mackey; T Middleton; William M. Sugden
Multiple regions within EBNA1 can link DNAs.
Journal of virology 1995;69(10):6199-208.
1995: T Mitchell; William M. Sugden
Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus.
Journal of virology 1995;69(5):2968-76.
1995: T A Gahn; William M. Sugden
An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene.
Journal of virology 1995;69(4):2633-6.
1995: Ann L Kirchmaier; William M. Sugden
Plasmid maintenance of derivatives of oriP of Epstein-Barr virus.
Journal of virology 1995;69(2):1280-3.
1995: Bettina Kempkes; Dagmar Pich; Reinhard Zeidler; William M. Sugden; Wolfgang Hammerschmidt
Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA.
Journal of virology 1995;69(1):231-8.
1994: T A Bloss; William M. Sugden
Optimal lengths for DNAs encapsidated by Epstein-Barr virus.
Journal of virology 1994;68(12):8217-22.
1994: T Middleton; William M. Sugden
Retention of plasmid DNA in mammalian cells is enhanced by binding of the Epstein-Barr virus replication protein EBNA1.
Journal of virology 1994;68(6):4067-71.
1993: T A Gahn; William M. Sugden
Marked, transient inhibition of expression of the Epstein-Barr virus latent membrane protein gene in Burkitt's lymphoma cell lines by electroporation.
Journal of virology 1993;67(11):6379-86.
1993: J M Martin; D Veis; S J Korsmeyer; William M. Sugden
Latent membrane protein of Epstein-Barr virus induces cellular phenotypes independently of expression of Bcl-2.
Journal of virology 1993;67(9):5269-78.
1993: William M. Sugden
How some retroviruses got their oncogenes.
Trends in biochemical sciences 1993;18(7):233-5.
1992: William M. Sugden
EBV's open sesame.
Trends in biochemical sciences 1992;17(7):239-40.
1992: T Middleton; William M. Sugden
A chimera of EBNA1 and the estrogen receptor activates transcription but not replication.
Journal of virology 1992;66(3):1795-8.
1992: T Middleton; William M. Sugden
EBNA1 can link the enhancer element to the initiator element of the Epstein-Barr virus plasmid origin of DNA replication.
Journal of virology 1992;66(1):489-95.
1991: J Martin; William M. Sugden
The latent membrane protein oncoprotein resembles growth factor receptors in the properties of its turnover.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(12):653-600.
1991: W Su; T Middleton; William M. Sugden; H Echols
DNA looping between the origin of replication of Epstein-Barr virus and its enhancer site: stabilization of an origin complex with Epstein-Barr nuclear antigen 1.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10870-4.
1991: J Martin; William M. Sugden
Transformation by the oncogenic latent membrane protein correlates with its rapid turnover, membrane localization, and cytoskeletal association.
Journal of virology 1991;65(6):3246-58.
1991: William M. Sugden
Herpes viruses: human transducing viruses.
Trends in biochemical sciences 1991;16(2):45-6.
1991: T Middleton; T A Gahn; J M Martin; William M. Sugden
Immortalizing genes of Epstein-Barr virus.
Advances in virus research 1991;40():19-55.
1990: L Sternås; T Middleton; William M. Sugden
The average number of molecules of Epstein-Barr nuclear antigen 1 per cell does not correlate with the average number of Epstein-Barr virus (EBV) DNA molecules per cell among different clones of EBV-immortalized cells.
Journal of virology 1990;64(5):2407-10.
1990: Wolfgang Hammerschmidt; William M. Sugden
DNA replication of herpesviruses during the lytic phase of their life-cycles.
Molecular biology & medicine 1990;7(1):45-57.
1989: Wolfgang Hammerschmidt; William M. Sugden
Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes.
Nature 1989;340(6232):393-7.
1989: William M. Sugden; N Warren
A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection.
Journal of virology 1989;63(6):2644-9.
1989: Wolfgang Hammerschmidt; William M. Sugden; V R Baichwal
The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels.
Journal of virology 1989;63(6):2469-75.
1989: William M. Sugden
Epstein-Barr virus. Synthesis for a complex role.
Nature 1989;339(6221):179-80.
1989: William M. Sugden
An intricate route to immortality.
Cell 1989;57(1):5-7.
1989: V R Baichwal; Wolfgang Hammerschmidt; William M. Sugden
Characterization of the BNLF-1 oncogene of Epstein-Barr virus.
Current topics in microbiology and immunology 1989;144():233-9.
1989: V R Baichwal; William M. Sugden
The multiple membrane-spanning segments of the BNLF-1 oncogene from Epstein-Barr virus are required for transformation.
Oncogene 1989;4(1):67-74.
1988: Wolfgang Hammerschmidt; William M. Sugden
Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus.
Cell 1988;55(3):427-33.
1988: V R Baichwal; William M. Sugden
Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.
Oncogene 1988;2(5):461-7.
1988: William M. Sugden; N Warren
Plasmid origin of replication of Epstein-Barr virus, oriP, does not limit replication in cis.
Molecular biology & medicine 1988;5(2):85-94.
1988: V R Baichwal; William M. Sugden
Latency comes of age for herpesviruses.
Cell 1988;52(6):787-9.
1987: V R Baichwal; William M. Sugden
Posttranslational processing of an Epstein-Barr virus-encoded membrane protein expressed in cells transformed by Epstein-Barr virus.
Journal of virology 1987;61(3):866-75.
1987: J Mecsas; William M. Sugden
Replication of plasmids derived from bovine papilloma virus type 1 and Epstein-Barr virus in cells in culture.
Annual review of cell biology 1987;3():87-108.
1986: D Reisman; William M. Sugden
trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.
Molecular and cellular biology 1986;6(11):3838-46.
1985: D Reisman; J Yates; William M. Sugden
A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.
Molecular and cellular biology 1985;5(8):1822-32.
1985: I G Miller; William M. Sugden
An identification of a transforming region of Epstein-Barr viral DNA cannot be confirmed.
Virology 1985;143(2):478-84.
1985: J L Yates; N Warren; William M. Sugden
Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells.
Nature 1985;313(6005):812-5.
1985: William M. Sugden; K Marsh; J Yates
A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus.
Molecular and cellular biology 1985;5(2):410-3.
1984: D Reisman; William M. Sugden
An EBNA-negative, EBV-genome-positive human lymphoblast cell line in which superinfecting EBV DNA is not maintained.
Virology 1984;137(1):113-26.
1984: William M. Sugden; J Yates; W Mark
Transforming functions associated with Epstein-Barr virus.
The Journal of investigative dermatology 1984;83(1 Suppl):82s-87s.
1984: J Yates; N Warren; D Reisman; William M. Sugden
A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(12):3806-10.
1983: William M. Sugden; S Metzenberg
Characterization of an antigen whose cell surface expression is induced by infection with Epstein-Barr virus.
Journal of virology 1983;46(3):800-7.
1982: W Mark; William M. Sugden
Transformation of lymphocytes by Epstein-Barr virus requires only one-fourth of the viral genome.
Virology 1982;122(2):431-43.
1982: William M. Sugden
Epstein-Barr virus: a human pathogen inducing lymphoproliferation in vivo and in vitro.
Reviews of infectious diseases 1982;4(5):1048-61.
1982: D J Grunwald; B Dale; J Dudley; W Lamph; William M. Sugden; B Ozanne; R Risser
Loss of viral gene expression and retention of tumorigenicity by Abelson lymphoma cells.
Journal of virology 1982;43(1):92-103.
1981: C Kintner; William M. Sugden
Identification of antigenic determinants unique to the surfaces of cells transformed by Epstein-Barr virus.
Nature 1981;294(5840):458-60.
1981: G N Buell; D Reisman; C Kintner; G Crouse; William M. Sugden
Cloning overlapping DNA fragments from the B95-8 strain of Epstein-Barr virus reveals a site of homology to the internal repetition.
Journal of virology 1981;40(3):977-82.
1981: C Kintner; William M. Sugden
Conservation and progressive methylation of Epstein-Barr viral DNA sequences in transformed cells.
Journal of virology 1981;38(1):305-16.
1979: William M. Sugden; M Phelps; J Domoradzki
Epstein-Barr virus DNA is amplified in transformed lymphocytes.
Journal of virology 1979;31(3):590-5.
1979: C R Kintner; William M. Sugden
The structure of the termini of the DNA of Epstein-Barr virus.
Cell 1979;17(3):661-71.
1979: William M. Sugden; C R Kintner; W Mark
The molecular biology of lymphotropic herpesviruses.
Advances in cancer research 1979;30():239-78.
1977: William M. Sugden
Comparison of Epstein-Barr viral DNAs in Burkitt lymphoma biopsy cells and in cells clonally transformed in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(10):4651-5.
1977: William M. Sugden; W Mark
Clonal transformation of adult human leukocytes by Epstein-Barr virus.
Journal of virology 1977;23(3):503-8.
1976: William M. Sugden; W C Summers; G Klein
Nucleic acid renaturation and restriction endonuclease cleavage analyses show that the DNAs of a transforming and a nontransforming strain of Epstein-Barr virus share approximately 90% of their nucleotide sequences.
Journal of virology 1976;18(2):765-75.
1975: William M. Sugden; B De Troy; R J Roberts; J Sambrook
Agarose slab-gel electrophoresis equipment.
Analytical biochemistry 1975;68(1):36-46.
1975: William M. Sugden
Viral RNA in cells carring Epstein-Barr virus.
IARC scientific publications 1975;(11 Pt 1):171-6.
1974: M Botchan; B Ozanne; William M. Sugden; Phillip A Sharp; J Sambrook
Viral DNA in transformed cells. III. The amounts of different regions of the SV40 genome present in a line of transformed mouse cells.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(10):4183-7.
1974: G Klein; William M. Sugden; W Leibold; J Menezes
Infection of EBV-genome-negative and -positive human lymphoblastoid cell lines with biologically different preparations of EBV.
Intervirology 1974;3(4):232-44.
1973: J Sambrook; William M. Sugden; W Keller; Phillip A Sharp
Transcription of simian virus 40. 3. Mapping of "early" and "late" species of RNA.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(12):3711-5.
1973: Phillip A Sharp; William M. Sugden; J Sambrook
Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis.
Biochemistry 1973;12(16):3055-63.
1973: William M. Sugden; W Keller
Mammalian deoxyribonucleic acid-dependent ribonucleic acid polymerases. I. Purification and properties of an -amanitin-sensitive ribonucleic acid polymerase and stimulatory factors from HeLa and KB cells.
The Journal of biological chemistry 1973;248(11):3777-88.
1972: A H Jackson; William M. Sugden
Inhibition by -amanitin of simian virus 40-specific ribonucleic acid synthesis in nuclei of infected monkey cells.
Journal of virology 1972;10(5):1086-9.