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Ernst Hafen

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Isabel Almudi; Ernst Hafen; Ingrid Poernbacher; Hugo Stocker
The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction.
Benjamin Schlager; Anna Straessle; Ernst Hafen
Use of anionic denaturing detergents to purify insoluble proteins after overexpression.
Julia M I Barth; Ernst Hafen; Katja Köhler
The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis.

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All Publications

2013: Isabel Almudi; Ernst Hafen; Ingrid Poernbacher; Hugo Stocker
The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction.
Cell communication and signaling : CCS 2013;11(1):26.
2012: Benjamin Schlager; Anna Straessle; Ernst Hafen
Use of anionic denaturing detergents to purify insoluble proteins after overexpression.
BMC biotechnology 2012;12():95.
2012: Julia M I Barth; Ernst Hafen; Katja Köhler
The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis.
BMC developmental biology 2012;12():35.
2011: Gerhard Seisenbacher; Ernst Hafen; Hugo Stocker
MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress.
PLoS genetics 2011;7(8):e1002168.
2011: J M I Barth; J Szabad; Ernst Hafen; K Köhler
Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis.
Cell death and differentiation 2011;18(6):915-24.
2011: Timo Glatter; Ruedi Aebersold; Hyungwon Choi; Ernst Hafen; Irena Jevtov; Martin A Jünger; Katja Köhler; Alexey I Nesvizhskii; Oliver Rinner; Katarzyna Roguska; Ralf B Schittenhelm; Alexander Schmidt; Hugo Stocker; Alexander Wepf; Matthias Gstaiger
Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome.
Molecular systems biology 2011;7():547.
2010: Jacques Montagne; Caroline Lecerf; Jean-Philippe Parvy; Janis M Bennion; Thomas Radimerski; Marie-Laure Ruhf; Frederic Zilbermann; nicole vouilloz; Hugo Stocker; Ernst Hafen; Sara C Kozma; George Thomas
The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila.
PLoS genetics 2010;6(5):e1000937.
2010: Cathy Slack; Christian Werz; Daniela Wieser; Nazif Alic; Andrea Foley; Hugo Stocker; Dominic J Withers; Janet M Thornton; Ernst Hafen; Linda Partridge
Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.
PLoS genetics 2010;6(3):e1000881.
2010: Roland Baumgartner; Ingrid Poernbacher; Nathalie Buser; Ernst Hafen; Hugo Stocker
The WW domain protein Kibra acts upstream of Hippo in Drosophila.
Developmental cell 2010;18(2):309-16.
2010: Tinri Aegerter-Wilmsen; Alister C Smith; Alix J Christen; Christof M Aegerter; Ernst Hafen; Konrad Basler
Exploring the effects of mechanical feedback on epithelial topology.
Development (Cambridge, England) 2010;137(3):499-506.
2010: Silvia Gluderer; Erich Brunner; Markus Germann; Virginija Jovaisaite; Changqing Li; Cyrill Rentsch; Ernst Hafen; Hugo Stocker
Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila.
Journal of biology 2010;9(1):9.
2009: Sandra Goetze; Ermir Qeli; Christian Mosimann; An Staes; Bertran Gerrits; Bernd Roschitzki; Sonali Mohanty; Eva M Niederer; Endre Laczko; Evy Timmerman; Vinzenz Lange; Ernst Hafen; Ruedi Aebersold; Joël Vandekerckhove; Konrad Basler; Christian H Ahrens; Kris Gevaert; Erich Brunner
Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster.
PLoS biology 2009;7(11):e1000236.
2009: Katja Köhler; Erich Brunner; Xue Li Guan; Karin Boucke; Urs F Greber; Sonali Mohanty; Julia M I Barth; Markus R Wenk; Ernst Hafen
A combined proteomic and genetic analysis identifies a role for the lipid desaturase Desat1 in starvation-induced autophagy in Drosophila.
Autophagy 2009;5(7):980-90.
2009: Christian Werz; Katja Köhler; Ernst Hafen; Hugo Stocker
The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway.
PLoS genetics 2009;5(8):e1000596.
2009: Ernst Hafen
Pushing single-gene genetic analysis up a Notch.
Developmental cell 2009;16(5):623-4.
2009: Isabel Almudi; Hugo Stocker; Ernst Hafen; Montserrat Corominas; Florenci Serras
SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development.
Developmental biology 2009;326(1):212-23.
2009: Sandra N Loevenich; Erich Brunner; Nichole L King; Eric W Deutsch; Stephen E Stein; Ruedi Aebersold; Ernst Hafen
The Drosophila melanogaster PeptideAtlas facilitates the use of peptide data for improved fly proteomics and genome annotation.
BMC bioinformatics 2009;10():59.
2008: Xiaodong Wu; Megumu Yamada-Mabuchi; Erick Morris; Pradeep Singh Tanwar; Leonard Dobens; Silvia Gluderer; Sabina Khan; Jing Cao; Hugo Stocker; Ernst Hafen; Nicholas J Dyson; Laurel A. Raftery
The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5414-9.
2008: Chung-Hui Yang; Priyanka Belawat; Ernst Hafen; Lily Yeh Jan; Yuh Nung Jan
Drosophila egg-laying site selection as a system to study simple decision-making processes.
Science (New York, N.Y.) 2008;319(5870):1679-83.
2008: Susan Broughton; Nazif Alic; Cathy Slack; Timothy M Bass; Tomoatsu Ikeya; Giovanna Vinti; Anna Maria Tommasi; Yasmine Driege; Ernst Hafen; Linda Partridge
Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs.
PloS one 2008;3(11):e3721.
2008: Basil Honegger; Milos Galic; Katja Köhler; franz wittwer; Walter Brogiolo; Ernst Hafen; Hugo Stocker
Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance.
Journal of biology 2008;7(3):10.
2008: Silvia Gluderer; Sean Oldham; Felix Rintelen; Andrea Sulzer; Corina Schütt; Xiaodong Wu; Laurel A. Raftery; Ernst Hafen; Hugo Stocker
Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth.
BMC developmental biology 2008;8():10.
2008: Yuan Wang; Christian Werz; Dongbin Xu; Zhihong Chen; Ying Li; Ernst Hafen; Andreas Bergmann
Drosophila cbl is essential for control of cell death and cell differentiation during eye development.
PloS one 2008;3(1):e1447.
2007: Edward Ryder; Michael Ashburner; Rosa Bautista-Llacer; Jenny Drummond; Jane Webster; Glynnis Johnson; Terri Morley; Yuk Sang Chan; Fiona Blows; Darin Coulson; Gunter Reuter; Heiko Baisch; Christian Apelt; Andreas Kauk; Thomas Rudolph; Maria Kube; Melanie Klimm; Claudia Nickel; Janos Szidonya; Peter Maróy; Margit Pal; Asa Rasmuson-Lestander; Karin Ekström; Hugo Stocker; Christoph Hugentobler; Ernst Hafen; David Gubb; Gert Pflugfelder; Christian Dorner; Bernard Mechler; Heide Schenkel; Joachim Marhold; Florenci Serras; Montserrat Corominas; Adrià Punset; John Roote; Steven Russell
The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource.
Genetics 2007;177(1):615-29.
2007: Christian H Ahrens; Erich Brunner; Ernst Hafen; Ruedi Aebersold; Konrad Basler
A proteome catalog of Drosophila melanogaster: an essential resource for targeted quantitative proteomics.
Fly 2007;1(3):182-6.
2007: Erich Brunner; Christian H Ahrens; Sonali Mohanty; Hansruedi Baetschmann; Sandra Loevenich; Frank Potthast; Eric Deutsch; Christian Panse; Ulrik de Lichtenberg; Oliver Rinner; Hookeun Lee; Patrick G A Pedrioli; Johan Malmstrom; Katja Koehler; Sabine Schrimpf; Jeroen Krijgsveld; Floyd Kregenow; albert heck; Ernst Hafen; Ralph Schlapbach; Ruedi Aebersold
A high-quality catalog of the Drosophila melanogaster proteome.
Nature biotechnology 2007;25(5):576-83.
2007: Tinri Aegerter-Wilmsen; Christof M Aegerter; Ernst Hafen; Konrad Basler
Model for the regulation of size in the wing imaginal disc of Drosophila.
Mechanisms of development 2007;124(4):318-26.
2006: Marta Sesé; Montserrat Corominas; Hugo Stocker; Tapio I Heino; Ernst Hafen; Florenci Serras
The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye.
Journal of cell science 2006;119(Pt 24):5047-56.
2006: Alana M O'Reilly; Anna C Ballew; Byron Miyazawa; Hugo Stocker; Ernst Hafen; Michael A Simon
Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells.
Development (Cambridge, England) 2006;133(14):2627-38.
2006: Knud Nairz; Carmen Rottig; Felix Rintelen; Evgeny M Zdobnov; Martin Moser; Ernst Hafen
Overgrowth caused by misexpression of a microRNA with dispensable wild-type function.
Developmental biology 2006;291(2):314-24.
2005: Anne-Claude Gingras; Michael Caballero; Marcel Zarske; Amy Sanchez; Tony R Hazbun; Stanley Fields; Nahum Sonenberg; Ernst Hafen; Brian Raught; Ruedi Aebersold
A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity.
Molecular & cellular proteomics : MCP 2005;4(11):1725-40.
2005: franz wittwer; Malika Jaquenoud; Walter Brogiolo; Marcel Zarske; Philipp Wüstemann; Rafael Fernandez; Hugo Stocker; Matthias P Wymann; Ernst Hafen
Susi, a negative regulator of Drosophila PI3-kinase.
Developmental cell 2005;8(6):817-27.
2005: Susan J Broughton; Matthew D W Piper; Tomoatsu Ikeya; Timothy M Bass; Jake Jacobson; Yasmine Driege; Pedro Martinez; Ernst Hafen; Dominic J Withers; Sally J Leevers; Linda Partridge
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3105-10.
2005: Christian Frei; Mireille Galloni; Ernst Hafen; Bruce A Edgar
The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth.
The EMBO journal 2005;24(3):623-34.
2005: Jan H Reiling; Kathrin T Doepfner; Ernst Hafen; Hugo Stocker
Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E.
Current biology : CB 2005;15(1):24-30.
2005: Peder Zipperlen; Knud Nairz; Ivo Rimann; Konrad Basler; Ernst Hafen; Michael O. Hengartner; Alex Hajnal
A universal method for automated gene mapping.
Genome biology 2005;6(2):R19.
2005: Frank Desiere; Eric W Deutsch; Alexey I Nesvizhskii; Parag Mallick; Nichole L King; Jimmy K Eng; Alan Aderem; Rose Boyle; Erich Brunner; Samuel Donohoe; Nelson Fausto; Ernst Hafen; Lee Hood; Michael G Katze; Kathleen A Kennedy; Floyd Kregenow; Hookeun Lee; Lin Biao; Dan Martin; Jeffrey A Ranish; David J Rawlings; Lawrence E Samelson; Yuzuru Shiio; Julian D Watts; Bernd Wollscheid; Michael E Wright; Wei Yan; Lihong Yang; Eugene C Yi; HUI ZHANG; Ruedi Aebersold
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
Genome biology 2005;6(1):R9.
2004: Ernst Hafen
Cancer, type 2 diabetes, and ageing: news from flies and worms.
Swiss medical weekly 2004;134(49-50):711-9.
2004: Jan H Reiling; Ernst Hafen
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila.
Genes & development 2004;18(23):2879-92.
2004: James Brugarolas; Kui Lei; Rebecca L Hurley; Brendan D Manning; Jan H Reiling; Ernst Hafen; Lee A Witters; Leif W Ellisen; William G Kaelin
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.
Genes & development 2004;18(23):2893-904.
2004: Maria E Giannakou; Martin Goss; Martin A Jünger; Ernst Hafen; Sally J Leevers; Linda Partridge
Long-lived Drosophila with overexpressed dFOXO in adult fat body.
Science (New York, N.Y.) 2004;305(5682):361.
2004: Dieter Egli; Ernst Hafen; Walter Schaffner
An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster.
Genome research 2004;14(7):1382-93.
2004: Edward Ryder; Fiona Blows; Michael Ashburner; Rosa Bautista-Llacer; Darin Coulson; Jenny Drummond; Jane Webster; David Gubb; Nicola Gunton; Glynnis Johnson; Cahir J O'Kane; David Huen; Punita Sharma; Zoltan Asztalos; Heiko Baisch; Janet Schulze; Maria Kube; Kathrin Kittlaus; Gunter Reuter; Peter Maroy; Janos Szidonya; Asa Rasmuson-Lestander; Karin Ekström; Barry Dickson; Christoph Hugentobler; Hugo Stocker; Ernst Hafen; JEAN-ANTOINE LEPESANT; Gert Pflugfelder; Martin Heisenberg; Bernard Mechler; Florenci Serras; Montserrat Corominas; Stephan Schneuwly; Thomas Preat; John Roote; Steven Russell
The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster.
Genetics 2004;167(2):797-813.
2004: Knud Nairz; Peder Zipperlen; Charles R Dearolf; Konrad Basler; Ernst Hafen
A reverse genetic screen in Drosophila using a deletion-inducing mutagen.
Genome biology 2004;5(10):R83.
2004: Lindsay K MacDougall; Mary Elizabeth Gagou; Sally J Leevers; Ernst Hafen; Michael D Waterfield
Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways.
Molecular and cellular biology 2004;24(2):796-808.
2004: Ernst Hafen
Interplay between growth factor and nutrient signaling: lessons from Drosophila TOR.
Current topics in microbiology and immunology 2004;279():153-67.
2003: Ernst Hafen; Hugo Stocker
How are the sizes of cells, organs, and bodies controlled?
PLoS biology 2003;1(3):E86.
2003: Felix Rintelen; Ernst Hafen; Knud Nairz
The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER.
Development (Cambridge, England) 2003;130(15):3479-90.
2003: Attila Garami; Fried J T Zwartkruis; Takahiro Nobukuni; Manel Joaquin; Marta Roccio; Hugo Stocker; Sara C Kozma; Ernst Hafen; Johannes L Bos; George Thomas
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
Molecular cell 2003;11(6):1457-66.
2003: Hugo Stocker; Thomas Radimerski; Benno Schindelholz; franz wittwer; Priyanka Belawat; Pierre Daram; Sebastian Breuer; George Thomas; Ernst Hafen
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
Nature cell biology 2003;5(6):559-65.
2003: Sean Oldham; Ernst Hafen
Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control.
Trends in cell biology 2003;13(2):79-85.
2003: Dieter Egli; Anand Selvaraj; Hasmik Yepiskoposyan; Bo Zhang; Ernst Hafen; Oleg Georgiev; Walter Schaffner
Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis.
The EMBO journal 2003;22(1):100-8.
2003: Martin A Jünger; Felix Rintelen; Hugo Stocker; Jonathan Wasserman; Mátyás Végh; Thomas Radimerski; Michael E Greenberg; Ernst Hafen
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.
Journal of biology 2003;2(3):20.
2002: Sean Oldham; Hugo Stocker; Muriel Laffargue; franz wittwer; Matthias P Wymann; Ernst Hafen
The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels.
Development (Cambridge, England) 2002;129(17):4103-9.
2002: Tomoatsu Ikeya; Milos Galic; Priyanka Belawat; Knud Nairz; Ernst Hafen
Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila.
Current biology : CB 2002;12(15):1293-300.
2002: Knud Nairz; Hugo Stocker; Benno Schindelholz; Ernst Hafen
High-resolution SNP mapping by denaturing HPLC.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10575-80.
2002: David Clancy; David Gems; Ernst Hafen; Sally J Leevers; Linda Partridge
Dietary restriction in long-lived dwarf flies.
Science (New York, N.Y.) 2002;296(5566):319.
2002: Hugo Stocker; Mirjana Andjelkovic; Sean Oldham; Muriel Laffargue; Matthias P Wymann; Brian A Hemmings; Ernst Hafen
Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.
Science (New York, N.Y.) 2002;295(5562):2088-91.
2002: Thomas Radimerski; Jacques Montagne; Felix Rintelen; Hugo Stocker; Jeroen van der Kaay; C Peter Downes; Ernst Hafen; George Thomas
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.
Nature cell biology 2002;4(3):251-5.
2002: Manolo Bellotto; Daniel Bopp; Kirsten-André Senti; Richard Burke; Peter Deak; Peter Maroy; Barry J Dickson; Konrad Basler; Ernst Hafen
Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome.
The International journal of developmental biology 2002;46(1):149-57.
2001: Felix Rintelen; Hugo Stocker; George Thomas; Ernst Hafen
PDK1 regulates growth through Akt and S6K in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15020-5.
2001: Marta Morey; Florenci Serras; Jaume Baguñà; Ernst Hafen; Montserrat Corominas
Modulation of the Ras/MAPK signalling pathway by the redox function of selenoproteins in Drosophila melanogaster.
Developmental biology 2001;238(1):145-56.
2001: K Halfar; C Rommel; Hugo Stocker; Ernst Hafen
Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity.
Development (Cambridge, England) 2001;128(9):1687-96.
2001: David Clancy; David Gems; L G Harshman; Sean Oldham; Hugo Stocker; Ernst Hafen; Sally J Leevers; Linda Partridge
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
Science (New York, N.Y.) 2001;292(5514):104-6.
2001: franz wittwer; A van der Straten; Krystyna Keleman; Barry J Dickson; Ernst Hafen
Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth.
Development (Cambridge, England) 2001;128(5):791-800.
2001: Walter Brogiolo; Hugo Stocker; Tomoatsu Ikeya; Felix Rintelen; R Fernandez; Ernst Hafen
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control.
Current biology : CB 2001;11(4):213-21.
2000: Sean Oldham; Jacques Montagne; Thomas Radimerski; George Thomas; Ernst Hafen
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin.
Genes & development 2000;14(21):2689-94.
2000: Hugo Stocker; Ernst Hafen
Genetic control of cell size.
Current opinion in genetics & development 2000;10(5):529-35.
2000: Sean Oldham; R Böhni; Hugo Stocker; Walter Brogiolo; Ernst Hafen
Genetic control of size in Drosophila.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1399):945-52.
1999: Richard Burke; Denise Nellen; Manolo Bellotto; Ernst Hafen; Kirsten-André Senti; Barry J Dickson; Konrad Basler
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.
Cell 1999;99(7):803-15.
1999: H Huang; Christopher J Potter; W Tao; DM Li; Walter Brogiolo; Ernst Hafen; Hong Sun; Tian Xu
PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development.
Development (Cambridge, England) 1999;126(23):5365-72.
1999: Jacques Montagne; M J Stewart; Hugo Stocker; Ernst Hafen; Sara C Kozma; George Thomas
Drosophila S6 kinase: a regulator of cell size.
Science (New York, N.Y.) 1999;285(5436):2126-9.
1999: R Böhni; JR Riesgo-Escovar; Sean Oldham; Walter Brogiolo; Hugo Stocker; Bernard F Andruss; Kathleen M Beckingham; Ernst Hafen
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.
Cell 1999;97(7):865-75.
1999: Pascale Feldmann; E N Eicher; Sally J Leevers; Ernst Hafen; David A Hughes
Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein.
Molecular and cellular biology 1999;19(3):1928-37.
1999: E Brunner; D Brunner; W Fu; Ernst Hafen; Konrad Basler
The dominant mutation Glazed is a gain-of-function allele of wingless that, similar to loss of APC, interferes with normal eye development.
Developmental biology 1999;206(2):178-88.
1998: K K Eberle; K E Zinsmaier; Sigrid Buchner; M Gruhn; M Jenni; C Arnold; Christian Leibold; D Reisch; N Walter; Ernst Hafen; A Hofbauer; G O Pflugfelder; Erich Buchner
Wide distribution of the cysteine string proteins in Drosophila tissues revealed by targeted mutagenesis.
Cell and tissue research 1998;294(2):203-17.
1998: C Rommel; Ernst Hafen
Ras--a versatile cellular switch.
Current opinion in genetics & development 1998;8(4):412-8.
1998: Ernst Hafen
Kinases and phosphatases--a marriage is consummated.
Science (New York, N.Y.) 1998;280(5367):1212-3.
1997: M Domínguez; Ernst Hafen
Hedgehog directly controls initiation and propagation of retinal differentiation in the Drosophila eye.
Genes & development 1997;11(23):3254-64.
1997: JR Riesgo-Escovar; Ernst Hafen; XS Hou; E S Goldstein; N Perrimon; B Glise; Stéphane Noselli; Lutz Kockel; J Zeitlinger; L M Staszewski; M Mlodzik; Dirk Bohmann
Connecting up the pathways in Drosophila development.
Trends in cell biology 1997;7(11):421-2.
1997: JR Riesgo-Escovar; Ernst Hafen
Common and distinct roles of DFos and DJun during Drosophila development.
Science (New York, N.Y.) 1997;278(5338):669-72.
1997: JR Riesgo-Escovar; Ernst Hafen
Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure.
Genes & development 1997;11(13):1717-27.
1997: C Rommel; Gerald Radziwill; Karin Moelling; Ernst Hafen
Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo.
Mechanisms of development 1997;64(1-2):95-104.
1997: A van der Straten; C Rommel; Barry J Dickson; Ernst Hafen
The heat shock protein 83 (Hsp83) is required for Raf-mediated signalling in Drosophila.
The EMBO journal 1997;16(8):1961-9.
1996: Sally J Leevers; David Weinkove; Lindsay K MacDougall; Ernst Hafen; Michael D Waterfield
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.
The EMBO journal 1996;15(23):6584-94.
1996: JR Riesgo-Escovar; M Jenni; A Fritz; Ernst Hafen
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.
Genes & development 1996;10(21):2759-68.
1996: N Oellers; Ernst Hafen
Biochemical characterization of rolledSem, an activated form of Drosophila mitogen-activated protein kinase.
The Journal of biological chemistry 1996;271(40):24939-44.
1996: Thomas Raabe; JR Riesgo-Escovar; Xiangdong Liu; B S Bausenwein; P Deak; P Maröy; Ernst Hafen
DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.
Cell 1996;85(6):911-20.
1996: M Domínguez; M Brunner; Ernst Hafen; Konrad Basler
Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus.
Science (New York, N.Y.) 1996;272(5268):1621-5.
1996: Karen Guillemin; J Groppe; K Ducker; R Treisman; Ernst Hafen; Markus Affolter; Mark A Krasnow
The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system.
Development (Cambridge, England) 1996;122(5):1353-62.
1996: Barry J Dickson; A van der Straten; M Dominguez; Ernst Hafen
Mutations Modulating Raf signaling in Drosophila eye development.
Genetics 1996;142(1):163-71.
1995: Thomas Raabe; Jean Paul olivier; Barry J Dickson; Xiangdong Liu; Gerald Gish; Tony Pawson; Ernst Hafen
Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.
The EMBO journal 1995;14(11):2509-18.
1995: Barry J Dickson; M Domínguez; A van der Straten; Ernst Hafen
Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase.
Cell 1995;80(3):453-62.
1994: D Brunner; K Dücker; N Oellers; Ernst Hafen; H Scholz; C Klämbt
The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway.
Nature 1994;370(6488):386-9.
1994: W H Biggs; KH Zavitz; Barry J Dickson; A van der Straten; D Brunner; Ernst Hafen; S Lawrence Zipursky
The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.
The EMBO journal 1994;13(7):1628-35.
1994: D Brunner; N Oellers; J Szabad; W H Biggs; S Lawrence Zipursky; Ernst Hafen
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.
Cell 1994;76(5):875-88.
1994: Fernando Diaz-Benjumea; Ernst Hafen
The sevenless signalling cassette mediates Drosophila EGF receptor function during epidermal development.
Development (Cambridge, England) 1994;120(3):569-78.
1994: M Reichman-Fried; Barry J Dickson; Ernst Hafen; Ben-Zion Shilo
Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration.
Genes & development 1994;8(4):428-39.
1994: Barry J Dickson; Ernst Hafen
Genetics of signal transduction in invertebrates.
Current opinion in genetics & development 1994;4(1):64-70.
1994: Ernst Hafen; Barry J Dickson; D Brunner; Thomas Raabe
Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.
Progress in neurobiology 1994;42(2):287-92.
1993: Ernst Hafen; Barry J Dickson; T Brunner; Thomas Raabe
Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;340(1293):273-8.
1993: Jean Paul olivier; Thomas Raabe; Mark Henkemeyer; Barry J Dickson; Geraldine Mbamalu; Benjamin L Margolis; J Schlessinger; Ernst Hafen; Tony Pawson
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.
Cell 1993;73(1):179-91.
1993: Ernst Hafen; Barry J Dickson; Thomas Raabe; D Brunner; N Oellers; A van der Straten
Genetic analysis of the sevenless signal transduction pathway of Drosophila.
Development (Cambridge, England). Supplement 1993;():41-6.
1992: Barry J Dickson; F Sprenger; D Morrison; Ernst Hafen
Raf functions downstream of Ras1 in the Sevenless signal transduction pathway.
Nature 1992;360(6404):600-3.
1992: Barry J Dickson; F Sprenger; Ernst Hafen
Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor.
Genes & development 1992;6(12A):2327-39.
1992: Christine Dambly-Chaudière; Elisabeth JAMET; M Burri; D Bopp; Konrad Basler; Ernst Hafen; N Dumont; Patrick Spielmann; Alain Ghysen; Markus Noll
The paired box gene pox neuro: a determinant of poly-innervated sense organs in Drosophila.
Cell 1992;69(1):159-72.
1991: Konrad Basler; Ernst Hafen
Specification of cell fate in the developing eye of Drosophila.
BioEssays : news and reviews in molecular, cellular and developmental biology 1991;13(12):621-31.
1991: Ernst Hafen
Patterning by cell recruitment in the Drosophila eye.
Current opinion in genetics & development 1991;1(2):268-74.
1991: Konrad Basler; B Christen; Ernst Hafen
Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye.
Cell 1991;64(6):1069-81.
1991: Ernst Hafen; Konrad Basler
Specification of cell fate in the developing eye of Drosophila.
Development (Cambridge, England). Supplement 1991;1():123-30.
1990: Konrad Basler; D Yen; A Tomlinson; Ernst Hafen
Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough.
Genes & development 1990;4(5):728-39.
1990: Ernst Hafen; Konrad Basler
Role of receptor tyrosine kinases during Drosophila development.
Ciba Foundation symposium 1990;150():191-204; discussion 204-11.
1990: Ernst Hafen; Konrad Basler
Mechanisms of positional signalling in the developing eye of Drosophila studied by ectopic expression of sevenless and rough.
Journal of cell science. Supplement 1990;13():157-68.
1990: Konrad Basler; Ernst Hafen
Receptor tyrosine kinases mediate cell-cell interactions during Drosophila development.
Progress in growth factor research 1990;2(1):15-27.
1989: Konrad Basler; Ernst Hafen
Dynamics of Drosophila eye development and temporal requirements of sevenless expression.
Development (Cambridge, England) 1989;107(4):723-31.
1989: Konrad Basler; P Siegrist; Ernst Hafen
The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements.
The EMBO journal 1989;8(8):2381-6.
1989: Konrad Basler; Ernst Hafen
Ubiquitous expression of sevenless: position-dependent specification of cell fate.
Science (New York, N.Y.) 1989;243(4893):931-4.
1988: Konrad Basler; Ernst Hafen
Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain.
Cell 1988;54(3):299-311.
1988: Konrad Basler; Ernst Hafen
Sevenless and Drosophila eye development: a tyrosine kinase controls cell fate.
Trends in genetics : TIG 1988;4(3):74-9.
1987: A Tomlinson; D D Bowtell; Ernst Hafen; Gerald M Rubin
Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila.
Cell 1987;51(1):143-50.
1987: Ernst Hafen; Konrad Basler; J E Edstroem; G M Rubin
Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain.
Science (New York, N.Y.) 1987;236(4797):55-63.
1985: Craig Montell; K Jones; Ernst Hafen; G Rubin
Rescue of the Drosophila phototransduction mutation trp by germline transformation.
Science (New York, N.Y.) 1985;230(4729):1040-3.
1984: Ernst Hafen; A Kuroiwa; W J Gehring
Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development.
Cell 1984;37(3):833-41.
1984: A Kuroiwa; Ernst Hafen; W J Gehring
Cloning and transcriptional analysis of the segmentation gene fushi tarazu of Drosophila.
Cell 1984;37(3):825-31.
1984: W McGinnis; M S Levine; Ernst Hafen; A Kuroiwa; W J Gehring
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes.
Nature 1984;308(5958):428-33.
1984: Ernst Hafen; M Levine; W J Gehring
Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila.
Nature 1984;307(5948):287-9.
1983: M Levine; Ernst Hafen; R L Garber; W J Gehring
Spatial distribution of Antennapedia transcripts during Drosophila development.
The EMBO journal 1983;2(11):2037-46.