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Christoph Neumann-Haefelin

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Christoph Neumann-Haefelin; Robert Thimme
Adaptive immune responses in hepatitis C virus infection.
Susanne Ziegler; Falko M Heinemann; Peter A Horn; Jacob Nattermann; Christoph Neumann-Haefelin; Marianne Ruhl; Ulrich Spengler; Hannelore Tenckhoff; Jörg Timm; Manfred Wiese
Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes.
Christoph Neumann-Haefelin; Hubert E Blum; Robert Thimme
[Direct antiviral treatment strategies in chronic hepatitis C].

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All Publications

2013: Christoph Neumann-Haefelin; Robert Thimme
Adaptive immune responses in hepatitis C virus infection.
Current topics in microbiology and immunology 2013;369():243-62.
2013: Susanne Ziegler; Falko M Heinemann; Peter A Horn; Jacob Nattermann; Christoph Neumann-Haefelin; Marianne Ruhl; Ulrich Spengler; Hannelore Tenckhoff; Jörg Timm; Manfred Wiese
Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes.
Journal of hepatology 2013;58(1):24-30.
2012: Christoph Neumann-Haefelin; Hubert E Blum; Robert Thimme
[Direct antiviral treatment strategies in chronic hepatitis C].
Deutsche medizinische Wochenschrift (1946) 2012;137(25-26):1360-5.
2012: Julia Schmidt; Stefan Tenzer; Hubert E Blum; Paul Bowness; Ute Distler; Emma Gostick; Astrid K N Iversen; Paul Klenerman; Volker Lohmann; Christoph Neumann-Haefelin; David A Price; Hansjörg Schild; Robert Thimme
Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.
PLoS pathogens 2012;8(11):e1003042.
2012: Nathalie Schmidt; Christoph Neumann-Haefelin; Robert Thimme
Cellular immune responses to hepatocellular carcinoma: lessons for immunotherapy.
Digestive diseases (Basel, Switzerland) 2012;30(5):483-91.
2011: Cesar Oniangue-Ndza; Karen A Power; Laura L Reyor; Robert Thimme; Yaoyu E Wang; Andrew Berical; Allyson K Bloom; Peter Kristian Foote; Adrianne D Gladden; Matthew R Henn; Kelsey Hills-Evans; Katherine Kane; Michael Kemper; Arthur Y Kim; Thomas Kuntzen; Georg M Lauer; Christoph Neumann-Haefelin; Todd M Allen
Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase.
Journal of virology 2011;85(22):11883-90.
2011: Mario Witkowski; Hubert E Blum; Ekaterina Breous; Nico Büttner; Oliver Drognitz; Ulrich T Hopt; Nadine Kersting; Christoph Neumann-Haefelin; Nasser Semmo; Hans Christian Spangenberg; Robert Thimme
Lack of ex vivo peripheral and intrahepatic α-fetoprotein-specific CD4+ responses in hepatocellular carcinoma.
International journal of cancer. Journal international du cancer 2011;129(9):2171-82.
2011: Christoph Neumann-Haefelin; Katja Nitschke; Cesar Oniangue-Ndza; Karen A Power; Laura L Reyor; Julia Schmidt; Alessandro Sette; John Sidney; Robert Thimme; Marco Binder; Stéphane Bressanelli; Célia Caillet-Saguy; Matthew R Henn; Kelsey Hills-Evans; Susan Ingber; Michael W Kemper; Nadine Kersting; Arthur Y Kim; Thomas Kuntzen; Georg M Lauer; Volker Lohmann; Todd M Allen
Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations.
Hepatology (Baltimore, Md.) 2011;54(4):1157-66.
2011: Bijan Raziorrouh; Winfried Schraut; Michael Spannagl; Robert Thimme; Axel Ulsenheimer; Martin Wächtler; Reinhart Zachoval; Jürgen Haas; Malte H J Heeg; Sophia Horster; Maria-Christina Jung; Peter Kurktschiev; Christoph Neumann-Haefelin; Helmut M Diepolder; Norbert Grüner
Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection.
Gastroenterology 2011;141(4):1422-31, 1431.e1-6.
2011: Marianne Ruhl; Torben Knuschke; Kevin Schewior; Lejla Glavinic; Christoph Neumann-Haefelin; Dae-In Chang; Marina Klein; Falko M Heinemann; Hannelore Tenckhoff; Manfred Wiese; Peter A Horn; Sergei Viazov; Ulrich Spengler; Michael Roggendorf; Norbert Scherbaum; Jacob Nattermann; Daniel Hoffmann; Jörg Timm
CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins.
Gastroenterology 2011;140(7):2064-73.
2011: Julia Schmidt; Christoph Neumann-Haefelin; Tayibe Altay; Emma Gostick; David A Price; Volker Lohmann; Hubert E Blum; Robert Thimme
Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency.
Journal of virology 2011;85(10):5232-6.
2011: Julia Schmidt; Robert Thimme; Christoph Neumann-Haefelin
Host genetics in immune-mediated hepatitis C virus clearance.
Biomarkers in medicine 2011;5(2):155-69.
2011: Christoph Neumann-Haefelin
[Protective role of HLA-B27 in HIV and hepatitis C virus infection].
Deutsche medizinische Wochenschrift (1946) 2011;136(7):320-4.
2011: Christoph Neumann-Haefelin; Robert Thimme
Success and failure of virus-specific T cell responses in hepatitis C virus infection.
Digestive diseases (Basel, Switzerland) 2011;29(4):416-22.
2010: Sergei Viazov; Stefan S Ross; Karen K Kyuregyan; Joerg Timm; Christoph Neumann-Haefelin; Olga V Isaeva; Oksana E Popova; Petr N Dmitriev; Fathia El Sharkawi; Robert Thimme; Michail I Michailov; Michael Roggendorf
Hepatitis C virus recombinants are rare even among intravenous drug users.
Journal of medical virology 2010;82(2):232-8.
2010: Christoph Neumann-Haefelin; Jörg Timm; Julia Schmidt; Nadine Kersting; Karen Fitzmaurice; Cesar Oniangue-Ndza; Michael N Kemper; Isla Humphreys; Susan McKiernan; Dermot Kelleher; Volker Lohmann; paul BOWNESS; Daniela Huzly; Hugo R Rosen; Arthur Y Kim; Georg M Lauer; Todd M Allen; Eleanor Barnes; Michael Roggendorf; Hubert E Blum; Robert Thimme
Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope.
Hepatology (Baltimore, Md.) 2010;51(1):54-62.
2009: Lukas Weseslindtner; Christoph Neumann-Haefelin; Sergei Viazov; Anita Haberstroh; Josef Kletzmayr; Judith H Aberle; Joerg Timm; Stefan R Ross; Renate Klauser-Braun; Thomas F Baumert; Michael Roggendorf; Robert Thimme; Heidemarie Holzmann
Acute infection with a single hepatitis C virus strain in dialysis patients: Analysis of adaptive immune response and viral variability.
Journal of hepatology 2009;50(4):693-704.
2009: Eva Dazert; Christoph Neumann-Haefelin; Stéphane Bressanelli; Karen Fitzmaurice; Julia Kort; Jörg Timm; Susan McKiernan; Dermot Kelleher; Norbert Gruener; John E Tavis; Hugo R Rosen; Jaqueline Shaw; paul BOWNESS; Hubert E Blum; Paul Klenerman; Ralf Bartenschlager; Robert Thimme
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.
The Journal of clinical investigation 2009;119(2):376-86.
2008: Robert Thimme; Michaela Neagu; Tobias Boettler; Christoph Neumann-Haefelin; Nadine Kersting; Michael Geissler; Frank Makowiec; Robert Obermaier; Ulrich T Hopt; Hubert E Blum; Hans Christian Spangenberg
Comprehensive analysis of the alpha-fetoprotein-specific CD8+ T cell responses in patients with hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2008;48(6):1821-33.
2008: Shadi Salloum; Cesar Oniangue-Ndza; Christoph Neumann-Haefelin; Laura Hudson; Silvia Giugliano; Marc Aus dem Siepen; Jacob Nattermann; Ulrich Spengler; Georg M Lauer; Manfred Wiese; Paul Klenerman; Helen Bright; Norbert Scherbaum; Robert Thimme; Michael Roggendorf; Sergei Viazov; Joerg Timm
Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs.
Journal of virology 2008;82(23):11803-12.
2008: Christoph Neumann-Haefelin; Hubert E Blum; Robert Thimme
[RNA interference as antiviral strategy].
Deutsche medizinische Wochenschrift (1946) 2008;133(46):2407-9.
2008: Christoph Neumann-Haefelin; Jörg Timm; Hans Christian Spangenberg; Natalie Wischniowski; Natalja Nazarova; Nadine Kersting; Michael Roggendorf; Todd M Allen; Hubert E Blum; Robert Thimme
Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection.
Hepatology (Baltimore, Md.) 2008;47(6):1824-36.
2008: Robert Thimme; Christoph Neumann-Haefelin; Tobias Boettler; Hubert E Blum
Adaptive immune responses to hepatitis C virus: from viral immunobiology to a vaccine.
Biological chemistry 2008;389(5):457-67.
2008: Christoph Neumann-Haefelin; David N Frick; Jing Jing Wang; Oliver G Pybus; Shadi Salloum; Gagandeep S Narula; Anna Eckart; Andrea Biezynski; Thomas Eiermann; Paul Klenerman; Sergei Viazov; Michael Roggendorf; Robert Thimme; Markus Reiser; Jörg Timm
Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level.
Journal of virology 2008;82(7):3438-51.
2008: Heidi Barth; Eva K Schnober; Christoph Neumann-Haefelin; Christine Thumann; Mirjam B Zeisel; Helmut M Diepolder; Zongyi Hu; TSANYANG LIANG; Hubert E Blum; Robert Thimme; Mélanie Lambotin; Thomas F Baumert
Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells.
Journal of virology 2008;82(7):3466-79.
2007: Christoph Eisenbach; Christoph Neumann-Haefelin; A Freyse; T Korsukéwitz; Birgit Hoyler; Wolfgang Stremmel; R Thimme; Jens Encke
Immune responses against HCV-NS3 after accidental infection with HCV-NS3 recombinant vaccinia virus.
Journal of viral hepatitis 2007;14(11):817-9.
2007: Christoph Neumann-Haefelin; Hans Christian Spangenberg; Hubert E Blum; Robert Thimme
Host and viral factors contributing to CD8+ T cell failure in hepatitis C virus infection.
World journal of gastroenterology : WJG 2007;13(36):4839-47.
2007: Christoph Neumann-Haefelin; Thomas Killinger; Jörg Timm; Scott Southwood; Denise McKinney; Hubert E Blum; Robert Thimme
Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site.
The Journal of general virology 2007;88(Pt 7):1986-91.
2007: Christoph Neumann-Haefelin; Robert Thimme
[Immunopathogenesis of viral hepatitis].
Praxis 2007;96(14):545-51.
2007: Christoph Neumann-Haefelin; Robert Thimme
Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection.
Genes and immunity 2007;8(3):181-92.
2007: Bertram Bengsch; Hans Christian Spangenberg; Nadine Kersting; Christoph Neumann-Haefelin; Elisabeth Panther; Fritz von Weizsäcker; Hubert E Blum; Hanspeter Pircher; Robert Thimme
Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver.
Journal of virology 2007;81(2):945-53.
2006: Christoph Neumann-Haefelin; Hubert E Blum; Robert Thimme
[Immunological T cell analyses -- current state and clinical relevance].
Deutsche medizinische Wochenschrift (1946) 2006;131(22):1273-8.
2006: Christoph Neumann-Haefelin; Susan McKiernan; Scott Ward; Sergei Viazov; Hans Christian Spangenberg; Thomas Killinger; Thomas F Baumert; Natalja Nazarova; Isabelle Sheridan; Oliver G Pybus; Fritz von Weizsäcker; Michael Roggendorf; Dermot Kelleher; Paul Klenerman; Hubert E Blum; Robert Thimme
Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution.
Hepatology (Baltimore, Md.) 2006;43(3):563-72.
2005: Hans Christian Spangenberg; Sergei Viazov; Nadine Kersting; Christoph Neumann-Haefelin; Denise McKinney; Michael Roggendorf; Fritz von Weizsäcker; Hubert E Blum; Robert Thimme
Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection.
Hepatology (Baltimore, Md.) 2005;42(4):828-37.
2005: Tobias Boettler; Hans Christian Spangenberg; Christoph Neumann-Haefelin; Elisabeth Panther; Simonetta Urbani; Carlo Ferrari; Hubert E Blum; Fritz von Weizsäcker; Robert Thimme
T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection.
Journal of virology 2005;79(12):7860-7.
2005: Heidi Barth; Axel Ulsenheimer; Gerd R Pape; Helmut M Diepolder; Marco Hoffmann; Christoph Neumann-Haefelin; Robert Thimme; Philipp Henneke; Reinhild Klein; Glaucia Paranhos-Baccalà; Erik Depla; TSANYANG LIANG; Hubert E Blum; Thomas F Baumert
Uptake and presentation of hepatitis C virus-like particles by human dendritic cells.
Blood 2005;105(9):3605-14.
2005: Christoph Neumann-Haefelin; H E Blum; F V Chisari; Robert Thimme
T cell response in hepatitis C virus infection.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2005;32(2):75-85.
2004: Christoph Neumann-Haefelin; Hans Christian Spangenberg; Robert Thimme; Hubert E Blum
[Suppressor T-cells: immunologic regulator cells and clinical perspectives].
Deutsche medizinische Wochenschrift (1946) 2004;129(30):1627-30.
2004: Elisabeth Panther; Hans Christian Spangenberg; Christoph Neumann-Haefelin; Kai M Rösler; Hubert E Blum; Fritz von Weizsäcker; Robert Thimme
[The role of the virus specific T-cell response in acute and chronic HBV and HCV infection].
Zeitschrift für Gastroenterologie 2004;42(1):39-46.
2000: Christoph Neumann-Haefelin; Ute Schäfer; Matthias Müller; Hans-Georg Koch
SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein.
The EMBO journal 2000;19(23):6419-26.
1999: Hans-Georg Koch; T Hengelage; Christoph Neumann-Haefelin; J MacFarlane; HK Hoffschulte; Karl-Ludwig Schimz; B Mechler; Matthias Müller
In vitro studies with purified components reveal signal recognition particle (SRP) and SecA/SecB as constituents of two independent protein-targeting pathways of Escherichia coli.
Molecular biology of the cell 1999;10(7):2163-73.