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Lewis Cantley

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Alfredo Csibi; Jamie M Dempsey; Sarah-Maria Fendt; Marcia Haigis; Elizabeth P Henske; Seung Min Jeong; Chenggang Li; Tasha Morrison; Andrey Parkhitko; George Poulogiannis; Gregory Stephanopoulos; Jane Yu; Lewis C Cantley; Douglas J Chapski; Andrew Y Choo; John Blenis
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4.
Anguraj Sadanandam; Bertram Wiedenmann; Stephan Wullschleger; Lewis C Cantley; Eric A Collisson; Maguy Del Rio; William J Gibb; Joe W Gray; Carsten Grotzinger; Krisztian Homicsko; William A Lannon; Benoit Lhermitte; Costas A Lyssiotis; Adam B Olshen; Liliane C Gonzalez Ostos; Douglas Hanahan
A colorectal cancer classification system that associates cellular phenotype and responses to therapy.
Jennifer L Gallop; Lewis C Cantley; Astrid Walrant; Marc W Kirschner
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.

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All Publications

2013: Alfredo Csibi; Jamie M Dempsey; Sarah-Maria Fendt; Marcia Haigis; Elizabeth P Henske; Seung Min Jeong; Chenggang Li; Tasha Morrison; Andrey Parkhitko; George Poulogiannis; Gregory Stephanopoulos; Jane Yu; Lewis C Cantley; Douglas J Chapski; Andrew Y Choo; John Blenis
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4.
Cell 2013;153(4):840-54.
2013: Anguraj Sadanandam; Bertram Wiedenmann; Stephan Wullschleger; Lewis C Cantley; Eric A Collisson; Maguy Del Rio; William J Gibb; Joe W Gray; Carsten Grotzinger; Krisztian Homicsko; William A Lannon; Benoit Lhermitte; Costas A Lyssiotis; Adam B Olshen; Liliane C Gonzalez Ostos; Douglas Hanahan
A colorectal cancer classification system that associates cellular phenotype and responses to therapy.
Nature medicine 2013;19(5):619-25.
2013: Jennifer L Gallop; Lewis C Cantley; Astrid Walrant; Marc W Kirschner
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):7193-8.
2013: Jaekyoung Son; Xiaoxu Wang; Haoqiang Ying; Matteo Ligorio; Costas A Lyssiotis; Edouard Mullarky; Rushika M Perera; Ng Shyh-Chang; John M Asara; Nabeel Bardeesy; Lewis C Cantley; Ronald A DePinho; Cristina R Ferrone; Jason B Fleming; Marcia C Haigis; Sujun Hua; Ya'an Kang; Alec C Kimmelman
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
Nature 2013;496(7443):101-5.
2013: Arkaitz Carracedo; Lewis C Cantley; Pier Paolo Pandolfi
Cancer metabolism: fatty acid oxidation in the limelight.
Nature reviews. Cancer 2013;13(4):227-32.
2013: Ning Wu; Bin Zheng; John Asara; Gary Bellinger; Yossi Dagon; Barbara B Kahn; Timothy E McGraw; Adam Shaywitz; Che-Hung Shen; Christine Tower; Jennifer Wen; Lewis C Cantley
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.
Molecular cell 2013;49(6):1167-75.
2013: Brooke M Emerling; Hui Liu; George Poulogiannis; Sabina Signoretti; Stephen Soltoff; Kazumi S Tsukazawa; Eric L Bell; Gary Bellinger; Cyril H Benes; Victoria Brown; Rayman Choo-Wing; Kevin Courtney; Lewis C Cantley
Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(9):3483-8.
2013: Ng Shyh-Chang; Ren Yi Teo; Juli J Unternaehrer; Jin Zhang; Yuxiang Zheng; Hao Zhu; George Q Daley; Jason W Locasale; Costas A Lyssiotis; Tamer Onder; Sutheera Ratanasirintrawoot; John M Asara; Lewis C Cantley
Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
Science (New York, N.Y.) 2013;339(6116):222-6.
2013: Sang Gyun Kim; Ki Won Lee; George Poulogiannis; Gwen R Buel; Lewis C Cantley; Andrew Y Choo; Raymond L Erikson; Gregory R Hoffman; Young Jin Jang; Bo-Yeon Kim; John Blenis
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
Molecular cell 2013;49(1):172-85.
2013: Mindy I Davis; Brooke M Emerling; Zhuyin Li; Sam Michael; Rajan Pragani; Atsuo T Sasaki; Min Shen; Douglas S Auld; Matthew Boxer; Lewis C Cantley; Kazutaka Sumita; Koh Takeuchi; Natasha Thorne; Anton Simeonov
A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.
PloS one 2013;8(1):e54127.
2013: Rachael Baker; Lewis C Cantley; Henrik G Dohlman; Brian Kuhlman; Steven M Lewis; Jason W Locasale; Atsuo T Sasaki; Emily M Wilkerson; Sharon L Campbell
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
Nature structural & molecular biology 2013;20(1):46-52.
2012: Costas A Lyssiotis; Lewis C Cantley
SIRT6 puts cancer metabolism in the driver's seat.
Cell 2012;151(6):1155-6.
2012: Weiwei Yang; Yanhua Zheng; Costas A Lyssiotis; Yan Xia; Kenneth Aldape; Lewis C Cantley; Xiaomin Chen; Fang Guo; Haitao Ji; Zhimin Lu
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Nature cell biology 2012;14(12):1295-304.
2012: Ashish Juvekar; Elaine P Lunsford; Costas A Lyssiotis; Caterina Nardella; Pier Paolo Pandolfi; Antonella Papa; Anbazhagan Rajendran; Ralph Scully; Katherine Spencer; John M Asara; Judith Balmañà; José Baselga; Laura N Burga; Lewis C Cantley; Hai Hu; Yasir H Ibrahim; Gerburg M Wulf
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer.
Cancer discovery 2012;2(11):1048-63.
2012: Saumya Das; Federica del Monte; Patrick T Ellinor; Evan L Graham; Katherine Hessler; Ashley C Knight; Michael R Morissette; Filomena G Ottaviano; Pablo A Quintero; Michael Rosenberg; Takeshi Aiba; Michael J Begley; Pontus Boström; Lewis C Cantley; Gordon F Tomaselli; Chunyang Xiao; Anthony Rosenzweig
Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling.
Circulation 2012;126(18):2208-19.
2012: Andrea P Myers; Lewis C Cantley
Sugar free, cancer free?
Nutrition (Burbank, Los Angeles County, Calif.) 2012;28(10):1036.
2012: Yossi Dagon; Elizabeth Hur; Kerry Wellenstein; Bin Zheng; Lewis C Cantley; Barbara B Kahn
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.
Cell metabolism 2012;16(1):104-12.
2012: Jill M Marinis; Christine McDonald; Lewis C Cantley; Brian A Cobb; Craig R Homer; Jessica E Hutti; Derek W Abbott
IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.
Molecular and cellular biology 2012;32(13):2479-89.
2012: Jason W Locasale; Tamar Melman; Susan Song; Kenneth D Swanson; Eric T Wong; Xuemei Yang; Lewis C Cantley; John M Asara
Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma.
Molecular & cellular proteomics : MCP 2012;11(6):M111.014688.
2012: Reuben J Shaw; Lewis C Cantley
Cell biology. Ancient sensor for ancient drug.
Science (New York, N.Y.) 2012;336(6083):813-4.
2012: Zhenxun Wang; Matthew G Vander Heiden; Martin Akerman; Lewis C Cantley; Deblina Chatterjee; Hyun Yong Jeon; Adrian R Krainer
Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons.
Journal of molecular cell biology 2012;4(2):79-87.
2012: Isabel Garcia-Cao; Carlotta Giorgi; Marcia C Haigis; Robin M Hobbs; Keisuke Ito; Gaelle Laurent; Dimitrios Anastasiou; Lewis C Cantley; Arkaitz Carracedo; Vincent C J de Boer; Paolo Pinton; Lucia Rameh; Atsuo T Sasaki; Min Sup Song; Matthew G Vander Heiden; Pier Paolo Pandolfi
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Cell 2012;149(1):49-62.
2012: William C Comb; Jessica E Hutti; Lewis C Cantley; Patricia C Cogswell; Albert S Baldwin
p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.
Molecular cell 2012;45(6):719-30.
2012: Dimitrios Anastasiou; Lewis C Cantley
Breathless cancer cells get fat on glutamine.
Cell research 2012;22(3):443-6.
2012: C H Benes; Lewis C Cantley; G Poulogiannis; Stephen Soltoff
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility.
Oncogene 2012;31(5):653-63.
2012: Steven N Quayle; Ruprecht Wiedemeyer; Richard K Wilson; Li Zhuang; Robert W Dewan; Li Ding; Emmet Huang-Hobbs; Jennifer Y Lee; Keith L Ligon; Gordon B Mills; Lewis C Cantley; Lydia W T Cheung; Lynda Chin
Somatic mutations of PIK3R1 promote gliomagenesis.
PloS one 2012;7(11):e49466.
2012: Jessica E Hutti; Albert S Baldwin; Lewis C Cantley; Adam W Cheely; Dmitri Kireev; Melissa A Porter; Xiaodong Wang; William P Janzen
Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.
PloS one 2012;7(7):e41494.
2012: Lewis C Cantley; José Baselga
Cancer Discovery at one year: the editors' interim analysis.
Cancer discovery 2012;2(1):vi.
2011: Dimitrios Anastasiou; John M Asara; Douglas S Auld; Gary Bellinger; Matthew B Boxer; Jian-kang Jiang; Jason W Locasale; George Poulogiannis; Atsuo T Sasaki; Min Shen; Craig J Thomas; Matthew G Vander Heiden; Lewis C Cantley
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Science (New York, N.Y.) 2011;334(6060):1278-83.
2011: Edouard Mullarky; Matthew G Vander Heiden; Lewis C Cantley; Katherine R Mattaini; Jason W Locasale
PHGDH amplification and altered glucose metabolism in human melanoma.
Pigment cell & melanoma research 2011;24(6):1112-5.
2011: Helen I Woodroof; Joe H Pogson; Daan M F van Aalten; Alexander J Whitworth; Dario R Alessi; Mike Begley; David G Campbell; Lewis C Cantley; Maria Deak; Miratul M K Muqit
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.
Open biology 2011;1(3):110012.
2011: Hiromichi Ebi; Cyril Benes; Lewis C Cantley; Zhao Chen; Ryan B Corcoran; Eugene Lifshits; Jeffrey A Meyerhardt; David P Ryan; Jeffrey Settleman; Anurag Singh; Youngchul Song; Kwok-Kin Wong; Jeffrey A Engelman
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.
The Journal of clinical investigation 2011;121(11):4311-21.
2011: Martin J Walsh; Douglas S Auld; James M Bougie; Kyle R Brimacombe; Lewis C Cantley; Thomas Daniel; William J Israelsen; William Leister; Min Shen; Craig J Thomas; Matthew G Vander Heiden; Henrike Veith; Matthew B Boxer
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorganic & medicinal chemistry letters 2011;21(21):6322-7.
2011: Daming Gao; Steven P Gygi; J Wade Harper; Hiroyuki Inuzuka; Pengda Liu; Jason W Locasale; Costas A Lyssiotis; Shavali Shaik; Meng-Kwang Marcus Tan; Alex Toker; Lixin Wan; John M Asara; Lewis C Cantley; Y Rebecca Chin; Hidefumi Fukushima; Bo Zhai; Wenyi Wei
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
Molecular cell 2011;44(2):290-303.
2011: Jason W Locasale; Lewis C Cantley
Metabolic flux and the regulation of mammalian cell growth.
Cell metabolism 2011;14(4):443-51.
2011: Xuemei Yang; Carlos L Arteaga; Lewis C Cantley; Jeffrey A Engelman; Pasi A Janne; Todd W Miller; Jie Qi; Brent N Rexer; Youngchul Song; Alexa B Turke; John M Asara
Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer.
Cancer research 2011;71(18):5965-75.
2011: Heather R Christofk; Ning Wu; Lewis C Cantley; John M Asara
Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries.
Journal of proteome research 2011;10(9):4158-64.
2011: Jason W Locasale; Costas A Lyssiotis; Katherine R Mattaini; Tamar Melman; Christian M Metallo; Matthew Meyerson; Edouard Mullarky; Taru Muranen; Andrea L Richardson; Atsuo T Sasaki; Mika Sasaki; Hadar Sharfi; Gregory Stephanopoulos; Dimitrios Anastasiou; John M Asara; Adam J Bass; Rameen Beroukhim; Joan S Brugge; Lewis C Cantley; Lynda Chin; Alexandra R Grassian; Gregory Heffron; Azra H Ligon; Natalie I Vokes; Gerhard Wagner; Matthew G Vander Heiden
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Nature genetics 2011;43(9):869-74.
2011: Jennifer Y Lee; Yu-Hsin Chiu; John Asara; Lewis C Cantley
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14157-62.
2011: Caroline H Yi; Bo Zhai; John M Asara; Lewis C Cantley; George Q Daley; Steven P Gygi; Gregory J Heffron; Sven G Hyberts; Il-Ho Jang; Fupeng Li; Chuan-Fa Liu; Jason W Locasale; Harry Luithardt; Heling Pan; Ricard Rodriguez-Mias; Jan Seebacher; Hadar Sharfi; Matthew G Vander Heiden; Gerhard Wagner; Renliang Yang; Junying Yuan
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.
Cell 2011;146(4):607-20.
2011: Caterina Nardella; Lewis C Cantley; Andrea Lunardi; Akash Patnaik; Pier Paolo Pandolfi
The APL paradigm and the "co-clinical trial" project.
Cancer discovery 2011;1(2):108-16.
2011: Lydia W T Cheung; Bojana Djordjevic; Mary D Dyer; Bryan T Hennessy; Zhenlin Ju; Jie Li; Han Liang; Karen H Lu; Yiling Lu; Andrea P Myers; Steven E Scherer; Katherine Stemke-Hale; Shuangxing Yu; Fan Zhang; Russell R Broaddus; Lewis C Cantley; Gordon B Mills
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
Cancer discovery 2011;1(2):170-85.
2011: Michale Bouskila; Lewis C Cantley; Maria Deak; Noor Esoof; Emily H Fang; Laurie Gay; Alan Prescott; Kate G Storey; Michael J Begley; Dario R Alessi
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.
The Biochemical journal 2011;437(1):157-67.
2011: Yonghao Yu; Lewis C Cantley; Steven P Gygi; Gregory R Hoffman; Neil Kubica; Xiaoju Max Ma; George Poulogiannis; Judit Villén; Qian Yang; Sang-Oh Yoon; John Blenis
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Science (New York, N.Y.) 2011;332(6035):1322-6.
2011: Lewis C Cantley; José Baselga
The era of cancer discovery.
Cancer discovery 2011;1(1):1.
2011: Xiao-Song Wang; Anastasia K Yocum; Irfan A Asangani; Bushra Ateeq; Lewis C Cantley; Qi Cao; Xuhong Cao; Saravana M Dhanasekaran; Daniel F Fries; Anuradha Gopalan; Bo Han; Xiaojun Jing; Emily Rose Kahoud; Yong Li; Gilbert S Omenn; Nallasivam Palanisamy; Dorothee Pflueger; John R Prensner; Victor E Reuter; Daniel Robinson; Mark A Rubin; Atsuo T Sasaki; Sunita Shankar; Sooryanarayana Lnu; Rui Wang; Arul M Chinnaiyan
Characterization of KRAS rearrangements in metastatic prostate cancer.
Cancer discovery 2011;1(1):35-43.
2011: Abdelhafid Saci; Lewis C Cantley; Christopher L Carpenter
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.
Molecular cell 2011;42(1):50-61.
2011: Peiling Tsou; Bin Zheng; Chia-Hsien Hsu; Atsuo Sasaki; Lewis C Cantley
A fluorescent reporter of AMPK activity and cellular energy stress.
Cell metabolism 2011;13(4):476-86.
2011: Tina L Yuan; Gerburg Wulf; Laura Burga; Lewis C Cantley
Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations.
Current biology : CB 2011;21(3):173-83.
2011: Atsuo Sasaki; Arkaitz Carracedo; Jason W Locasale; Dimitrios Anastasiou; Koh Takeuchi; Emily Rose Kahoud; Sasson Haviv; John M Asara; Pier Paolo Pandolfi; Lewis C Cantley
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
Science signaling 2011;4(163):ra13.
2010: Kazuma Kaneko; Kohjiro Ueki; Noriko Takahashi; Shinji Hashimoto; Masayuki Okamoto; Motoharu Awazawa; Yukiko Okazaki; Miho Ohsugi; Kazunori Inabe; Toshihiro Umehara; Masashi Yoshida; Masafumi Kakei; Tadahiro Kitamura; Ji Luo; Rohit N Kulkarni; C Ronald Kahn; Haruo Kasai; Lewis C Cantley; Takashi Kadowaki
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.
Cell metabolism 2010;12(6):619-32.
2010: Jason W Locasale; Matthew G Vander Heiden; Lewis C Cantley
Rewiring of glycolysis in cancer cell metabolism.
Cell cycle (Georgetown, Tex.) 2010;9(21):4253.
2010: Y Baba; Katsuhiko Nosho; K Shima; Jeffrey A Meyerhardt; A T Chan; Jeffrey A Engelman; Lewis C Cantley; Massimo Loda; E Giovannucci; Charlie S Fuchs; Shuji Ogino
Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.
British journal of cancer 2010;103(7):1025-33.
2010: Matthew G Vander Heiden; Jason W Locasale; Kenneth D Swanson; Hadar Sharfi; Greg J Heffron; Daniel Amador-Noguez; Heather R Christofk; Gerhard Wagner; Joshua D Rabinowitz; John M Asara; Lewis C Cantley
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Science (New York, N.Y.) 2010;329(5998):1492-9.
2010: Andrea P Myers; Lewis C Cantley
Targeting a common collaborator in cancer development.
Science translational medicine 2010;2(48):48ps45.
2010: Jeffrey A Engelman; Lewis C Cantley
Chemoprevention meets glucose control.
Cancer prevention research (Philadelphia, Pa.) 2010;3(9):1049-52.
2010: George Poulogiannis; Rebecca E McIntyre; Maria Dimitriadi; John R Apps; Catherine H Wilson; Koichi Ichimura; Feijun Luo; Lewis C Cantley; Andrew H Wyllie; David J Adams; Mark J Arends
PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(34):15145-50.
2010: Cullen M Taniguchi; Jonathon Winnay; Tatsuya Kondo; Roderick T Bronson; Alexander R Guimaraes; José O Alemán; Ji Luo; Gregory Stephanopoulos; Ralph Weissleder; Lewis C Cantley; C Ronald Kahn
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.
Cancer research 2010;70(13):5305-15.
2010: Lenny Dang; David W White; Stefan Gross; Bryson D Bennett; Mark A Bittinger; Edward M Driggers; Valeria R Fantin; Hyun Gyung Jang; Shengfang Jin; Marie C Keenan; Kevin M Marks; Robert M Prins; Patrick S Ward; Katharine E Yen; Linda M Liau; Joshua D Rabinowitz; Lewis C Cantley; Craig Thompson; Matthew G Vander Heiden; Shinsan M Su
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature 2010;465(7300):966.
2010: Jian-kang Jiang; Matthew B Boxer; Matthew G Vander Heiden; Min Shen; Amanda P Skoumbourdis; Noel Southall; Henrike Veith; William Leister; Christopher P Austin; Hee Won Park; James Inglese; Lewis C Cantley; Douglas S Auld; Craig J Thomas
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorganic & medicinal chemistry letters 2010;20(11):3387-93.
2010: Andrew Y Choo; Sang Gyun Kim; Matthew G Vander Heiden; Sarah J Mahoney; Hieu Vu; Sang-Oh Yoon; Lewis C Cantley; John Blenis
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.
Molecular cell 2010;38(4):487-99.
2010: Matthew G Vander Heiden; Heather R Christofk; Eli Schuman; Alexander O Subtelny; Hadar Sharfi; Edward E Harlow; Jun Xian; Lewis C Cantley
Identification of small molecule inhibitors of pyruvate kinase M2.
Biochemical pharmacology 2010;79(8):1118-24.
2010: Hiroshi Takeuchi; Takako Takeuchi; Jing Gao; Lewis C Cantley; Masato Hirata
Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking.
Molecular and cellular biology 2010;30(7):1689-702.
2010: Matthew B Boxer; Jian-kang Jiang; Matthew G Vander Heiden; Min Shen; Amanda P Skoumbourdis; Noel Southall; Henrike Veith; William Leister; Christopher P Austin; Hee Won Park; James Inglese; Lewis C Cantley; Douglas S Auld; Craig J Thomas
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Journal of medicinal chemistry 2010;53(3):1048-55.
2010: Cynthia V Clower; Deblina Chatterjee; Zhenxun Wang; Lewis C Cantley; Matthew G Vander Heiden; Adrian R Krainer
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):1894-9.
2010: Kwok-Kin Wong; Jeffrey A Engelman; Lewis C Cantley
Targeting the PI3K signaling pathway in cancer.
Current opinion in genetics & development 2010;20(1):87-90.
2010: Kazuhiro Shiga; Kentaro Takayama; Shiroh Futaki; Jessica E Hutti; Lewis C Cantley; Katsuko Ueki; Yoshitaka Ono; Hideyuki Mukai
Development of an intracellularly acting inhibitory peptide selective for PKN.
The Biochemical journal 2010;425(2):445-543.
2010: Albrecht Moritz; Yu Li; Ailan Guo; Judit Villén; Yi Wang; Joan MacNeill; Jon Kornhauser; Kam Sprott; Jing Zhou; Anthony Possemato; Jian Min Ren; Peter Hornbeck; Lewis C Cantley; Steven P Gygi; John Rush; Michael J Comb
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.
Science signaling 2010;3(136):ra64.
2010: Jason W Locasale; Lewis C Cantley
Altered metabolism in cancer.
BMC biology 2010;8():88.
2010: Tina L Yuan; Lewis C Cantley
Introduction.
Current topics in microbiology and immunology 2010;346():1-7.
2010: Malcolm Leissring; Enrico Malito; Sabrine Hedouin; Lael Reinstatler; Tomoko Sahara; Samer Abdul-Hay; Shakeel Choudhry; Ghulam M Maharvi; Abdul Fauq; Malwina Huzarska; Philip S May; Sungwoon Choi; Todd P Logan; Benjamin E Turk; Lewis C Cantley; Marika Manolopoulou; Wei-Jen Tang; Ross L Stein; Gregory D Cuny; Dennis J Selkoe
Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
PloS one 2010;5(5):e10504.
2009: Lenny Dang; David W White; Stefan Gross; Bryson D Bennett; Mark A Bittinger; Edward M Driggers; Valeria R Fantin; Hyun Gyung Jang; Shengfang Jin; Marie C Keenan; Kevin M Marks; Robert M Prins; Patrick S Ward; Katharine E Yen; Linda M Liau; Joshua D Rabinowitz; Lewis C Cantley; Craig Thompson; Matthew G Vander Heiden; Shinsan M Su
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature 2009;462(7274):739-44.
2009: Andrea P Myers; Jeffrey A Meyerhardt; Lewis C Cantley
Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy?
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):6748-50.
2009: R Jeremy Nichols; Nicolas Dzamko; Jessica E Hutti; Lewis C Cantley; Maria Deak; Jennifer Moran; Paul Bamborough; Alastair D Reith; Dario R Alessi
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
The Biochemical journal 2009;424(1):47-60.
2009: R Adam Smith; Hushan Yuan; Ralph Weissleder; Lewis C Cantley; Lee Josephson
A wortmannin-cetuximab as a double drug.
Bioconjugate chemistry 2009;20(11):2185-9.
2009: Jennifer W Hill; Yong Xu; Frederic Preitner; Makota Fukuda; You-Ree Cho; Ji Luo; Nina Balthasar; Roberto Coppari; Lewis C Cantley; Barbara B Kahn; Jean J Zhao; Joel K Elmquist
Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.
Endocrinology 2009;150(11):4874-82.
2009: Jason W Locasale; Lewis C Cantley; Matthew G Vander Heiden
Cancer's insatiable appetite.
Nature biotechnology 2009;27(10):916-7.
2009: Carla Mouta-Bellum; Aleksander Kirov; Laura Miceli-Libby; Maria L Mancini; Tatiana V Petrova; Lucy Liaw; Igor Prudovsky; Philip E Thorpe; Naoyuki Miura; Lewis C Cantley; Kari Alitalo; David A Fruman; Calvin P H Vary
Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(10):2670-9.
2009: Christina Gewinner; Zhigang C Wang; Andrea Richardson; Julie T Feldstein; Dariush Etemadmoghadam; David D L Bowtell; Jordi Barretina; William M Lin; Lucia Rameh; Leonardo Salmena; Pier Paolo Pandolfi; Lewis C Cantley
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
Cancer cell 2009;16(2):115-25.
2009: Lewis C Cantley
Lewis C. Cantley.
Current biology : CB 2009;19(14):R540-1.
2009: Adam Smith; Joe Blois; Hushan Yuan; Elena Aikawa; Christian Ellson; Jose-Luiz Figueiredo; Ralph Weissleder; Rainer Kohler; Michael B Yaffe; Lewis C Cantley; Lee Josephson
The antiproliferative cytostatic effects of a self-activating viridin prodrug.
Molecular cancer therapeutics 2009;8(6):1666-75.
2009: Matthew G Vander Heiden; Lewis C Cantley; Craig Thompson
Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Science (New York, N.Y.) 2009;324(5930):1029-33.
2009: Jessica E Hutti; Rhine R Shen; Derek W Abbott; Alicia Y Zhou; Kam M Sprott; John M Asara; William C Hahn; Lewis C Cantley
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.
Molecular cell 2009;34(4):461-72.
2009: Mary Higby Schweitzer; Wenxia Zheng; Chris L Organ; Recep Avci; Zhiyong Suo; Lisa M Freimark; Valerie S Lebleu; Michael B Duncan; Matthew G Vander Heiden; John Neveu; William Stratton Lane; John S Cottrell; John R Horner; Lewis C Cantley; Raghu Kalluri; John M Asara
Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis.
Science (New York, N.Y.) 2009;324(5927):626-31.
2009: Shuji Ogino; Katsuhiko Nosho; Gregory J Kirkner; Kaori Shima; Natsumi Irahara; Shoko Kure; Andrew T Chan; Jeffrey A Engelman; Peter Kraft; Lewis C Cantley; Edward L Giovannucci; Charles S Fuchs
PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(9):1477-84.
2009: Paul Nicklin; Philip Bergman; Bailin Zhang; Ellen Triantafellow; Henry Wang; Beat Nyfeler; Haidi Yang; Marc Hild; Charles Kung; Christopher Wilson; Vic E Myer; Jeffrey P MacKeigan; Jeffrey A Porter; Y Karen Wang; Lewis C Cantley; Peter M Finan; Leon O Murphy
Bidirectional transport of amino acids regulates mTOR and autophagy.
Cell 2009;136(3):521-34.
2009: Bin Zheng; Joseph H Jeong; John M Asara; Yuan-Ying Yuan; Scott R Granter; Lynda Chin; Lewis C Cantley
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.
Molecular cell 2009;33(2):237-47.
2009: Taro Hitosugi; Sumin Kang; Matthew G Vander Heiden; Tae-Wook Chung; Shannon Elf; Katherine Lythgoe; Shaozhong Dong; Sagar Lonial; Xu Wang; Georgia Z Chen; Jianxin Xie; Ting-Lei Gu; Roberto D Polakiewicz; Johannes L Roesel; Titus Boggon; Fadlo R Khuri; D Gary Gilliland; Lewis C Cantley; Jonathan Kaufman; Jing Chen
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Science signaling 2009;2(97):ra73.
2008: Jeffrey A Engelman; Liang Chen; Xiaohong Tan; Katherine Crosby; Alexander R Guimaraes; Rabi Upadhyay; Michel Maira; Kate McNamara; Samanthi A Perera; Youngchul Song; Lucian R Chirieac; Ramneet Kaur; Angela Lightbown; Jessica Simendinger; Timothy Li; Robert F Padera; Carlos García-Echeverría; Ralph Weissleder; Umar Mahmood; Lewis C Cantley; Kwok-Kin Wong
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Nature medicine 2008;14(12):1351-6.
2008: T L Yuan; Lewis C Cantley
PI3K pathway alterations in cancer: variations on a theme.
Oncogene 2008;27(41):5497-510.
2008: Adam J Shaywitz; Kevin D Courtney; Akash Patnaik; Lewis C Cantley
PI3K enters beta-testing.
Cell metabolism 2008;8(3):179-81.
2008: Arkaitz Carracedo; Li Ma; Julie T Feldstein; Federico Rojo; Leonardo Salmena; Andrea Alimonti; Ainara Egia; Atsuo Sasaki; George Thomas; Sara C Kozma; Antonella Papa; Caterina Nardella; Lewis C Cantley; Jose Baselga; Pier Paolo Pandolfi
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.
The Journal of clinical investigation 2008;118(9):3065-74.
2008: Joe Blois; Hushan Yuan; Adam Smith; Michael E Pacold; Ralph Weissleder; Lewis C Cantley; Lee Josephson
Slow self-activation enhances the potency of viridin prodrugs.
Journal of medicinal chemistry 2008;51(15):4699-707.
2008: Tina L Yuan; Hak Soo Choi; Aya Matsui; Cyril Benes; Eugene Lifshits; Ji Luo; John V Frangioni; Lewis C Cantley
Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(28):9739-44.
2008: Jeffrey A Engelman; Lewis C Cantley
A sweet new role for EGFR in cancer.
Cancer cell 2008;13(5):375-6.
2008: Jennifer W Hill; Kevin W Williams; Chianping Ye; Ji Luo; Nina Balthasar; Roberto Coppari; Michael Alexander cowley; Lewis C Cantley; Bradford B Lowell; Joel K Elmquist
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
The Journal of clinical investigation 2008;118(5):1796-805.
2008: Chris L Organ; Mary H Schweitzer; Wenxia Zheng; Lisa M Freimark; Lewis C Cantley; John M Asara
Molecular phylogenetics of mastodon and Tyrannosaurus rex.
Science (New York, N.Y.) 2008;320(5875):499.
2008: Heather R Christofk; Matthew G Vander Heiden; Marian H Harris; Arvind Ramanathan; Robert E Gerszten; Ru Wei; Mark D Fleming; Stuart L Schreiber; Lewis C Cantley
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Nature 2008;452(7184):230-3.
2008: Heather R Christofk; Matthew G Vander Heiden; Ning Wu; John M Asara; Lewis C Cantley
Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Nature 2008;452(7184):181-6.
2008: John M Asara; Heather R Christofk; Lisa M Freimark; Lewis C Cantley
A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.
Proteomics 2008;8(5):994-9.
2008: Katie R Barnes; Joe Blois; Adam Smith; Hushan Yuan; Fred Reynolds; Ralph Weissleder; Lewis C Cantley; Lee Josephson
Fate of a bioactive fluorescent wortmannin derivative in cells.
Bioconjugate chemistry 2008;19(1):130-7.
2007: Jessica E Hutti; Benjamin E Turk; John M Asara; Averil Ma; Lewis C Cantley; Derek W Abbott
IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.
Molecular and cellular biology 2007;27(21):7451-61.
2007: John M Asara; John S Garavelli; David A Slatter; Mary Higby Schweitzer; Lisa M Freimark; Matthew Phillips; Lewis C Cantley
Interpreting sequences from mastodon and T. rex.
Science (New York, N.Y.) 2007;317(5843):1324-5.
2007: Derek W Abbott; Yibin Yang; Jessica E Hutti; Swetha Madhavarapu; Michelle A Kelliher; Lewis C Cantley
Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.
Molecular and cellular biology 2007;27(17):6012-25.
2007: Jennifer Y Lee; Jeffrey A Engelman; Lewis C Cantley
Biochemistry. PI3K charges ahead.
Science (New York, N.Y.) 2007;317(5835):206-7.
2007: Brendan D Manning; Lewis C Cantley
AKT/PKB signaling: navigating downstream.
Cell 2007;129(7):1261-74.
2007: Jeffrey A Engelman; Kreshnik Zejnullahu; Tetsuya Mitsudomi; Youngchul Song; Courtney Hyland; Joon Oh Park; Neal Lindeman; Christopher-Michael Gale; Xiaojun Zhao; James Christensen; Takayuki Kosaka; Alison J Holmes; Andrew M Rogers; Federico Cappuzzo; Tony Shu Kam Mok; Charles Lee; Bruce E Johnson; Lewis C Cantley; Pasi A Janne
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Science (New York, N.Y.) 2007;316(5827):1039-43.
2007: James D Chang; Galina K Sukhova; Peter Libby; Eugenia Schvartz; Alice H Lichtenstein; Seth J Field; Caitlin Kennedy; Swetha Madhavarapu; Ji Luo; Dianqing Wu; Lewis C Cantley
Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8077-82.
2007: John M Asara; Mary Higby Schweitzer; Lisa M Freimark; Matthew Phillips; Lewis C Cantley
Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry.
Science (New York, N.Y.) 2007;316(5822):280-5.
2007: Betsy Perry; Jacqueline Banyard; Elizabeth R McLaughlin; Randy Watnick; Allie Sohn; David N Brindley; Toshiyuki Obata; Lewis C Cantley; Cynthia Cohen; Jack L Arbiser
AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.
Archives of dermatology 2007;143(4):504-6.
2007: Cullen M Taniguchi; José O Aleman; Kohjiro Ueki; Ji Luo; Tomoichiro Asano; Hideaki Kaneto; Gregory Stephanopoulos; Lewis C Cantley; C Ronald Kahn
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Molecular and cellular biology 2007;27(8):2830-40.
2007: Jonathan Deane; Michael G Kharas; Jean S Oak; Linda N Stiles; Ji Luo; Travis I Moore; Hong Ji; Christian Rommel; Lewis C Cantley; Thomas E Lane; David A Fruman
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.
Blood 2007;109(7):2894-902.
2007: Jonathan B Hurov; Mei Huang; Lynn S White; Jochen Lennerz; Cheol Soo Choi; You-Ree Cho; Hyo-Jeong Kim; Julie L Prior; David Piwnica-Worms; Lewis C Cantley; Jason K Kim; Gerald I Shulman; Helen Piwnica-Worms
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5680-5.
2007: Liam J Holt; Jessica E Hutti; Lewis C Cantley; David O Morgan
Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis.
Molecular cell 2007;25(5):689-702.
2007: Bin Zheng; Lewis C Cantley
Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):819-22.
2006: Jean S Oak; Jonathan Deane; Michael G Kharas; Ji Luo; Thomas E Lane; Lewis C Cantley; David A Fruman
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16882-7.
2006: Jeffrey A Engelman; Toru Mukohara; Kreshnik Zejnullahu; Eugene Lifshits; Ana M Borrás; Christopher-Michael Gale; George N Naumov; Beow Y Yeap; Emily Jarrell; Jason Sun; Sean Tracy; Xiaojun Zhao; John V Heymach; Bruce E Johnson; Lewis C Cantley; Pasi A Janne
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.
The Journal of clinical investigation 2006;116(10):2695-706.
2006: Cullen M Taniguchi; Thien Tran; Tatsuya Kondo; Ji Luo; Kohjiro Ueki; Lewis C Cantley; C Ronald Kahn
Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):12093-7.
2006: Jeffrey A Engelman; Ji Luo; Lewis C Cantley
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Nature reviews. Genetics 2006;7(8):606-19.
2006: Jeffrey A Engelman; Lewis C Cantley
The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4372s-4376s.
2006: Reuben J. Shaw; Lewis C Cantley
Ras, PI(3)K and mTOR signalling controls tumour cell growth.
Nature 2006;441(7092):424-30.
2006: Harald Schulze; Manav Korpal; Jonathan Hurov; Sang-We Kim; Jinghang Zhang; Lewis C Cantley; Thomas Graf; Ramesh A Shivdasani
Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.
Blood 2006;107(10):3868-75.
2006: Ji Luo; Cassandra L Sobkiw; Michael F Hirshman; M Nicole Logsdon; Timothy Q Li; Laurie J Goodyear; Lewis C Cantley
Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.
Cell metabolism 2006;3(5):355-66.
2006: Cullen M Taniguchi; Tatsuya Kondo; Mini P Sajan; Ji Luo; Roderick Bronson; Tomoichiro Asano; Robert Farese; Lewis C Cantley; C Ronald Kahn
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.
Cell metabolism 2006;3(5):343-53.
2006: Benjamin E Turk; Daniel H Lee; Yasuo Yamakoshi; Andreas Klingenhoff; Ernst Reichenberger; John Wright; James P Simmer; Justin A Komisarof; Lewis C Cantley; John D Bartlett
MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen.
Biochemistry 2006;45(12):3863-74.
2006: Orion D Weiner; Maike C Rentel; Alex Ott; Glenn E Brown; Mark Jedrychowski; Michael B Yaffe; Steven P Gygi; Lewis C Cantley; Henry R Bourne; Marc W Kirschner
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
PLoS biology 2006;4(2):e38.
2006: Benjamin E Turk; Jessica E Hutti; Lewis C Cantley
Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates.
Nature protocols 2006;1(1):375-9.
2006: John M Asara; Xiang Zhang; Bin Zheng; Lisa A Maroney; Heather R Christofk; Ning Wu; Lewis C Cantley
In-gel stable isotope labeling for relative quantification using mass spectrometry.
Nature protocols 2006;1(1):46-51.
2006: John M Asara; Xiang Zhang; Bin Zheng; Heather H Christofk; Ning Wu; Lewis C Cantley
In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification.
Journal of proteome research 2006;5(1):155-63.
2005: Reuben J. Shaw; Katja A Lamia; Debbie Vasquez; Seung-Hoi Koo; Nabeel Bardeesy; Ronald A DePinho; Marc Montminy; Lewis C Cantley
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Science (New York, N.Y.) 2005;310(5754):1642-6.
2005: Steven J Isakoff; Jeffrey A Engelman; Hanna Yoko Irie; Ji Luo; Saskia M Brachmann; Rachel V Pearline; Lewis C Cantley; Joan S Brugge
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells.
Cancer research 2005;65(23):10992-1000.
2005: Linda A Barbour; Shaikh Mizanoor Rahman; Inga Gurevich; J Wayne Leitner; Stephanie J Fischer; Michael D Roper; Trina A Knotts; Yen Vo; Carrie E McCurdy; Shoshana Yakar; Derek LeRoith; C Ronald Kahn; Lewis C Cantley; Jacob E Friedman; Boris Draznin
Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
The Journal of biological chemistry 2005;280(45):37489-94.
2005: Ji Luo; Julie R McMullen; Cassandra L Sobkiw; Li Zhang; Adam L Dorfman; Megan C Sherwood; M Nicole Logsdon; James W Horner; Ronald A DePinho; Seigo Izumo; Lewis C Cantley
Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.
Molecular and cellular biology 2005;25(21):9491-502.
2005: Ji Luo; Lewis C Cantley
The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer.
Cell cycle (Georgetown, Tex.) 2005;4(10):1309-12.
2005: Heike Keilhack; Frank S David; Malcolm McGregor; Lewis C Cantley; Benjamin G Neel
Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.
The Journal of biological chemistry 2005;280(35):30984-93.
2005: Toru Mukohara; Jeffrey A Engelman; Nasser H Hanna; Beow Y Yeap; Susumu Kobayashi; Neal Lindeman; Balazs Halmos; Joseph Pearlberg; Zenta Tsuchihashi; Lewis C Cantley; Daniel G Tenen; Bruce E Johnson; Pasi A Janne
Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations.
Journal of the National Cancer Institute 2005;97(16):1185-94.
2005: Seth J Field; Nikki Madson; Monica L Kerr; Kenneth A A Galbraith; Caitlin E Kennedy; Mamta Tahiliani; Andrew Wilkins; Lewis C Cantley
PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis.
Current biology : CB 2005;15(15):1407-12.
2005: Ji Luo; Seth J Field; Jennifer Y Lee; Jeffrey A Engelman; Lewis C Cantley
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.
The Journal of cell biology 2005;170(3):455-64.
2005: Brendan D Manning; M Nicole Logsdon; Alex I Lipovsky; Derek Abbott; David J Kwiatkowski; Lewis C Cantley
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.
Genes & development 2005;19(15):1773-8.
2005: Ji Luo; Cassandra L Sobkiw; Nicole M Logsdon; John M Watt; Sabina Signoretti; Fionnuala O'Connell; Eyoung Shin; Youngju Shim; Lily Pao; Benjamin G Neel; Ronald A DePinho; Massimo Loda; Lewis C Cantley
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10238-43.
2005: Choong-Min Kang; Derek W Abbott; Sang Tae Park; Christopher Dascher; Lewis C Cantley; Robert N Husson
The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.
Genes & development 2005;19(14):1692-704.
2005: Jaehong Park; Yanhui Hu; T V S Murthy; Fredrik Vannberg; Binghua Shen; Andreas Rolfs; Jessica E Hutti; Lewis C Cantley; Joshua LaBaer; Ed Harlow; leonardo brizuela
Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8114-9.
2005: Cyril H Benes; Ning Wu; Andrew E H Elia; Tejal Dharia; Lewis C Cantley; Stephen Soltoff
The C2 domain of PKCdelta is a phosphotyrosine binding domain.
Cell 2005;121(2):271-80.
2005: Norvin Fernandes; Yingli Sun; Shujuan Chen; Proma Paul; Reuben J. Shaw; Lewis C Cantley; Brendan Price
DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.
The Journal of biological chemistry 2005;280(15):15158-64.
2005: Saskia M Brachmann; Claudine M Yballe; Metello Innocenti; Jonathan Deane; David A Fruman; Sheila M Thomas; Lewis C Cantley
Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.
Molecular and cellular biology 2005;25(7):2593-606.
2005: Jeffrey A Engelman; Pasi A Janne; Craig Mermel; Joseph Pearlberg; Toru Mukohara; Christina Fleet; Karen Cichowski; Bruce E Johnson; Lewis C Cantley
ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3788-93.
2005: Saskia M Brachmann; Kohjiro Ueki; Jeffrey A Engelman; Ronald C Kahn; Lewis C Cantley
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.
Molecular and cellular biology 2005;25(5):1596-607.
2005: Or Gozani; Seth J Field; Colin G Ferguson; Mark Ewalt; Christopher Mahlke; Lewis C Cantley; Glenn D Prestwich; Junying Yuan
Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms.
Advances in enzyme regulation 2005;45():171-85.
2004: Derek W Abbott; Andrew Wilkins; John M Asara; Lewis C Cantley
The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.
Current biology : CB 2004;14(24):2217-27.
2004: Jessica E Hutti; Emily T Jarrell; James D Chang; Derek W Abbott; Peter Storz; Alex Toker; Lewis C Cantley; Benjamin E Turk
A rapid method for determining protein kinase phosphorylation specificity.
Nature methods 2004;1(1):27-9.
2004: Angela L Williamson; Paolo Lecchi; Benjamin E Turk; Youngchool Choe; Peter J Hotez; James H McKerrow; Lewis C Cantley; Mohammed Sajid; Charles S Craik; Alex Loukas
A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.
The Journal of biological chemistry 2004;279(34):35950-7.
2004: Sean A Beausoleil; Mark Jedrychowski; Daniel Schwartz; Josh Elias; Judit Villén; Jiaxu Li; Martin A Cohn; Lewis C Cantley; Steven P Gygi
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12130-5.
2004: Partha Mitra; Yingjie Zhang; Lucia E Rameh; Maria Ivshina; Dannel McCollum; John J Nunnari; Gregory M Hendricks; Monica L Kerr; Seth J Field; Lewis C Cantley; Alonzo H Ross
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
The Journal of cell biology 2004;166(2):205-11.
2004: Reuben J. Shaw; Nabeel Bardeesy; Brendan D Manning; Lyle Lopez; Monica Kosmatka; Ronald A DePinho; Lewis C Cantley
The LKB1 tumor suppressor negatively regulates mTOR signaling.
Cancer cell 2004;6(1):91-9.
2004: Orna Halevy; Lewis C Cantley
Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells.
Experimental cell research 2004;297(1):224-34.
2004: Katja A Lamia; Odile D Peroni; Young-Bum Kim; Lucia E Rameh; Barbara B Kahn; Lewis C Cantley
Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.
Molecular and cellular biology 2004;24(11):5080-7.
2004: Benjamin E Turk; Lewis C Cantley
Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes.
Methods (San Diego, Calif.) 2004;32(4):398-405.
2004: James D Chang; Seth J Field; Lucia E Rameh; Christopher L Carpenter; Lewis C Cantley
Identification and characterization of a phosphoinositide phosphate kinase homolog.
The Journal of biological chemistry 2004;279(12):11672-9.
2004: Reuben J. Shaw; Monica Kosmatka; Nabeel Bardeesy; Rebecca L Hurley; Lee A Witters; Ronald A DePinho; Lewis C Cantley
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3329-35.
2004: Zhou Songyang; Lewis C Cantley
ZIP codes for delivering SH2 domains.
Cell 2004;116(2 Suppl):S41-3, 2 p following S48.
2004: Benjamin E Turk; Lewis C Cantley
Peptide libraries: at the crossroads of proteomics and bioinformatics.
Drug discovery today 2004;9(2 Suppl):S47-52.
2004: Lewis C Cantley
The role of phosphoinositide 3-kinase in human disease.
Harvey lectures 2004;100():103-22.
2004: Rekha G Panchal; Ann R Hermone; Tam L Nguyen; Thiang Yian Wong; Robert Schwarzenbacher; James Schmidt; Douglas Lane; Connor McGrath; Benjamin E Turk; James Burnett; M Javad Aman; Stephen Little; Edward A Sausville; Daniel W Zaharevitz; Lewis C Cantley; Robert C Liddington; Rick Gussio; Sina Bavari
Identification of small molecule inhibitors of anthrax lethal factor.
Nature structural & molecular biology 2004;11(1):67-72.
2004: Benjamin E Turk; Thiang Yian Wong; Robert Schwarzenbacher; Emily T Jarrell; Stephen H Leppla; R. John Collier; Robert C Liddington; Lewis C Cantley
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Nature structural & molecular biology 2004;11(1):60-6.
2003: L Miguel Martins; Benjamin E Turk; Victoria Cowling; Annabel Borg; Emily T Jarrell; Lewis C Cantley; Julian Downward
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
The Journal of biological chemistry 2003;278(49):49417-27.
2003: Kohjiro Ueki; David A Fruman; Claudine M Yballe; Mathias Fasshauer; Johannes Klein; Tomoichiro Asano; Lewis C Cantley; C Ronald Kahn
Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
The Journal of biological chemistry 2003;278(48):48453-66.
2003: Brendan D Manning; Lewis C Cantley
Rheb fills a GAP between TSC and TOR.
Trends in biochemical sciences 2003;28(11):573-6.
2003: Andrew E H Elia; Peter Rellos; Lesley F Haire; Jerry W Chao; Frank J Ivins; Katja Höpker; Duaa Mohammad; Lewis C Cantley; Stephen John Smerdon; Michael B Yaffe
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
Cell 2003;115(1):83-95.
2003: Ji Luo; Brendan D Manning; Lewis C Cantley
Targeting the PI3K-Akt pathway in human cancer: rationale and promise.
Cancer cell 2003;4(4):257-62.
2003: Aaron M Woolsey; Lisa Sunwoo; Christine Petersen; Saskia M Brachmann; Lewis C Cantley; Barbara A Burleigh
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation.
Journal of cell science 2003;116(Pt 17):3611-22.
2003: Valerie Carricaburu; Katja A Lamia; Elizabeth Lo; Laetitia Favereaux; Bernard Payrastre; Lewis C Cantley; Lucia E Rameh
The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9867-72.
2003: Andrew R Tee; Brendan D Manning; Philippe Roux; Lewis C Cantley; John Blenis
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Current biology : CB 2003;13(15):1259-68.
2003: Takashi Katome; Toshiyuki Obata; Rie Matsushima; Norihisa Masuyama; Lewis C Cantley; Yukiko Gotoh; Kazuhiro Kishi; Hiroshi Shiota; Yousuke Ebina
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions.
The Journal of biological chemistry 2003;278(30):28312-23.
2003: Or Gozani; philip karuman; David R Jones; Dmitri N. Ivanov; James Cha; Alexey A Lugovskoy; Cheryl L Baird; zhu hongwen; Seth J Field; Stephen L Lessnick; Jennifer Villasenor; Bharat Mehrotra; Jian Chen; Vikram R Rao; Joan S Brugge; Colin G Ferguson; Bernard Payrastre; David G Myszka; Lewis C Cantley; Gerhard Wagner; Nullin Divecha; Glenn D Prestwich; Junying Yuan
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
Cell 2003;114(1):99-111.
2003: John C Obenauer; Lewis C Cantley; Michael B Yaffe
Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs.
Nucleic acids research 2003;31(13):3635-41.
2003: Brendan D Manning; Lewis C Cantley
United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling.
Biochemical Society transactions 2003;31(Pt 3):573-8.
2003: Andrew E H Elia; Lewis C Cantley; Michael B Yaffe
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
Science (New York, N.Y.) 2003;299(5610):1228-31.
2003: Daniel Hallmann; Katja Trümper; Heidi Trusheim; Kohjiro Ueki; C Ronald Kahn; Lewis C Cantley; David A Fruman; Dieter Hörsch
Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.
The Journal of biological chemistry 2003;278(7):5099-108.
2003: Benjamin E Turk; Lewis C Cantley
Peptide libraries: at the crossroads of proteomics and bioinformatics.
Current opinion in chemical biology 2003;7(1):84-90.
2002: Brendan D Manning; Lewis C Cantley
Hitting the target: emerging technologies in the search for kinase substrates.
Science's STKE : signal transduction knowledge environment 2002;2002(162):pe49.
2002: Andrew R Tee; Diane C Fingar; Brendan D Manning; David J Kwiatkowski; Lewis C Cantley; John Blenis
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13571-6.
2002: Hyun I Park; Benjamin E Turk; Ferry E Gerkema; Lewis C Cantley; Qing-Xiang Amy Sang
Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26.
The Journal of biological chemistry 2002;277(38):35168-75.
2002: Stephan D Voss; Alec M DeGrand; Giulio Romeo; Lewis C Cantley; John V Frangioni
An integrated vector system for cellular studies of phage display-derived peptides.
Analytical biochemistry 2002;308(2):364-72.
2002: Brendan D Manning; Andrew R Tee; M Nicole Logsdon; John Blenis; Lewis C Cantley
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
Molecular cell 2002;10(1):151-62.
2002: Orion D Weiner; Paul O Neilsen; Glenn D Prestwich; Marc W Kirschner; Lewis C Cantley; Henry R Bourne
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.
Nature cell biology 2002;4(7):509-13.
2002: Lewis C Cantley
The phosphoinositide 3-kinase pathway.
Science (New York, N.Y.) 2002;296(5573):1655-7.
2002: Seth J Field; Katja A Lamia; Lucia E Rameh; Lewis C Cantley
Lipid research picks up speed on the slopes of Taos.
Developmental cell 2002;2(4):407-10.
2002: Tetsuo Shioi; Julie R McMullen; Peter M Kang; Pamela S Douglas; Toshiyuki Obata; Thomas F Franke; Lewis C Cantley; Seigo Izumo
Akt/protein kinase B promotes organ growth in transgenic mice.
Molecular and cellular biology 2002;22(8):2799-809.
2002: Alla Y Karpova; Maren Trost; John M Murray; Lewis C Cantley; Peter M Howley
Interferon regulatory factor-3 is an in vivo target of DNA-PK.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2818-23.
2002: David A Fruman; Lewis C Cantley
Phosphoinositide 3-kinase in immunological systems.
Seminars in immunology 2002;14(1):7-18.
2002: Kohjiro Ueki; David A Fruman; Saskia M Brachmann; Yu-Hua Tseng; Lewis C Cantley; C Ronald Kahn
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
Molecular and cellular biology 2002;22(3):965-77.
2002: Kohjiro Ueki; Claudine M Yballe; Saskia M Brachmann; David Vicent; John M Watt; C Ronald Kahn; Lewis C Cantley
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):419-24.
2002: Franck Mauvais-Jarvis; Kohjiro Ueki; David A Fruman; Michael F Hirshman; Kei Sakamoto; Laurie J Goodyear; Matteo Iannacone; Domenico Accili; Lewis C Cantley; C Ronald Kahn
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.
The Journal of clinical investigation 2002;109(1):141-9.
2001: Atif Zaheer; Robert E Lenkinski; A Mahmood; A G Jones; Lewis C Cantley; John V Frangioni
In vivo near-infrared fluorescence imaging of osteoblastic activity.
Nature biotechnology 2001;19(12):1148-54.
2001: Otilia V Vieira; Roberto J Botelho; Lucia E Rameh; S M Brachmann; Tsuyoshi Matsuo; H W Davidson; A Schreiber; Jonathan M Backer; Lewis C Cantley; Sergio Grinstein
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation.
The Journal of cell biology 2001;155(1):19-25.
2001: F Kanai; H Liu; S J Field; H Akbary; T Matsuo; Glenn E Brown; Lewis C Cantley; Michael B Yaffe
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.
Nature cell biology 2001;3(7):675-8.
2001: B E Turk; L L Huang; E T Piro; Lewis C Cantley
Determination of protease cleavage site motifs using mixture-based oriented peptide libraries.
Nature biotechnology 2001;19(7):661-7.
2001: Colleen Sweeney; D Fambrough; C Huard; A John Diamonti; E S Lander; Lewis C Cantley; Kermit L Carraway
Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors.
The Journal of biological chemistry 2001;276(25):22685-98.
2001: Lewis C Cantley
Transcription. Translocating tubby.
Science (New York, N.Y.) 2001;292(5524):2019-21.
2001: philip karuman; Or Gozani; Robert D Odze; X C Zhou; zhu hongwen; Reuben J. Shaw; Tom P Brien; C D Bozzuto; D Ooi; Lewis C Cantley; Junying Yuan
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
Molecular cell 2001;7(6):1307-19.
2001: Greg P Bertenshaw; Boris Turk; Simon Hubbard; Gail L Matters; John E Bylander; Jacqueline M Crisman; Lewis C Cantley; Judith S Bond
Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.
The Journal of biological chemistry 2001;276(16):13248-55.
2001: Michael B Yaffe; GG Leparc; J Lai; T Obata; Stefano Volinia; Lewis C Cantley
A motif-based profile scanning approach for genome-wide prediction of signaling pathways.
Nature biotechnology 2001;19(4):348-53.
2000: Fumihiko Kanai; Paola Marignani; Dilara Sarbassova; R Yagi; R A Hall; Mark Donowitz; A Hisaminato; T Fujiwara; Y Ito; Lewis C Cantley; Michael B Yaffe
TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
The EMBO journal 2000;19(24):6778-91.
2000: T Obata; Michael B Yaffe; GG Leparc; E T Piro; H Maegawa; A Kashiwagi; R Kikkawa; Lewis C Cantley
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.
The Journal of biological chemistry 2000;275(46):36108-15.
2000: David A Fruman; Franck Mauvais-Jarvis; D A Pollard; Claudine M Yballe; Derek Brazil; R T Bronson; C Ronald Kahn; Lewis C Cantley
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha.
Nature genetics 2000;26(3):379-82.
2000: K Nishikawa; Sansana Sawasdikosol; David A Fruman; J Lai; Zhou Songyang; Steven J Burakoff; Michael B Yaffe; Lewis C Cantley
A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase.
Molecular cell 2000;6(4):969-74.
2000: John V Frangioni; L M LaRiccia; Lewis C Cantley; M R Montminy
Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening.
Nature biotechnology 2000;18(10):1080-5.
2000: Colleen Sweeney; C Lai; D J Riese; A John Diamonti; Lewis C Cantley; Kermit L Carraway
Ligand discrimination in signaling through an ErbB4 receptor homodimer.
The Journal of biological chemistry 2000;275(26):19803-7.
2000: Tetsuo Shioi; Peter M Kang; Pamela S Douglas; J Hampe; C M Yballe; Joel Lawitts; Lewis C Cantley; Seigo Izumo
The conserved phosphoinositide 3-kinase pathway determines heart size in mice.
The EMBO journal 2000;19(11):2537-48.
2000: JM Lu-Kuo; David A Fruman; D M Joyal; Lewis C Cantley; Howard Katz
Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.
The Journal of biological chemistry 2000;275(8):6022-9.
2000: Kimberley F Tolias; John H Hartwig; H Ishihara; Y Shibasaki; Lewis C Cantley; Christopher L Carpenter
Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.
Current biology : CB 2000;10(3):153-6.
2000: SC Bunnell; M Diehn; M B Yaffe; P R Findell; Lewis C Cantley; Leslie J Berg
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.
The Journal of biological chemistry 2000;275(3):2219-30.
1999: Laurie O Beitz; David A Fruman; T Kurosaki; Lewis C Cantley; Andrew M Scharenberg
SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.
The Journal of biological chemistry 1999;274(46):32662-6.
1999: Florence Poy; M B Yaffe; Joan Sayos; K Saxena; Massimo Morra; Janos Sumegi; Lewis C Cantley; Cox Terhorst; Michael J Eck
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Molecular cell 1999;4(4):555-61.
1999: José Aramburu; Michael B Yaffe; Cristina López-Rodríguez; Lewis C Cantley; Patrick G Hogan; Anjana Rao
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
Science (New York, N.Y.) 1999;285(5436):2129-33.
1999: David A Fruman; S B Snapper; Claudine M Yballe; F W Alt; Lewis C Cantley
Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation.
Biochemical Society transactions 1999;27(4):624-9.
1999: Katrin Rittinger; J Budman; J Xu; Stefano Volinia; Lewis C Cantley; Stephen John Smerdon; Steven J Gamblin; Michael B Yaffe
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
Molecular cell 1999;4(2):153-66.
1999: David A Fruman; Lucia E Rameh; Lewis C Cantley
Phosphoinositide binding domains: embracing 3-phosphate.
Cell 1999;97(7):817-20.
1999: Lewis C Cantley; Benjamin G Neel
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4240-5.
1999: Kimberley F Tolias; Lewis C Cantley
Pathways for phosphoinositide synthesis.
Chemistry and physics of lipids 1999;98(1-2):69-77.
1999: Lucia E Rameh; Lewis C Cantley
The role of phosphoinositide 3-kinase lipid products in cell function.
The Journal of biological chemistry 1999;274(13):8347-50.
1999: David A Fruman; S B Snapper; Claudine M Yballe; L Davidson; J Y Yu; F W Alt; Lewis C Cantley
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.
Science (New York, N.Y.) 1999;283(5400):393-7.
1998: C S Crovello; C Lai; Lewis C Cantley; Kermit L Carraway
Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2.
The Journal of biological chemistry 1998;273(41):26954-61.
1998: Lucia E Rameh; S G Rhee; Katherine C Spokes; Andrius Kazlauskas; Lewis C Cantley; Lloyd G Cantley
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling.
The Journal of biological chemistry 1998;273(37):23750-7.
1998: K Nishikawa; A Toker; K Wong; Paola Marignani; F J Johannes; Lewis C Cantley
Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase.
The Journal of biological chemistry 1998;273(36):23126-33.
1998: Kimberley F Tolias; Lucia E Rameh; H Ishihara; Y Shibasaki; J Chen; G D Prestwich; Lewis C Cantley; Christopher L Carpenter
Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate.
The Journal of biological chemistry 1998;273(29):18040-6.
1998: Andrew M Scharenberg; O El-Hillal; David A Fruman; Laurie O Beitz; Z Li; S Lin; I Gout; Lewis C Cantley; David J Rawlings; Jean-Pierre Kinet
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.
The EMBO journal 1998;17(7):1961-72.
1998: Le Ma; Lewis C Cantley; Paul A Janmey; Marc W Kirschner
Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts.
The Journal of cell biology 1998;140(5):1125-36.
1998: Kimberley F Tolias; A D Couvillon; Lewis C Cantley; Christopher L Carpenter
Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex.
Molecular and cellular biology 1998;18(2):762-70.
1998: Stephen Soltoff; Hava Karsenty Avraham; Shalom Avraham; Lewis C Cantley
Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.
The Journal of biological chemistry 1998;273(5):2653-60.
1998: Jes K Klarlund; Lucia E Rameh; Lewis C Cantley; JM Buxton; John Holik; C Sakelis; V Patki; Silvia Corvera; Michael P Czech
Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate.
The Journal of biological chemistry 1998;273(4):1859-62.
1998: R E Meyers; Lewis C Cantley
Phosphatidylinositol 4-kinases. Assays and product analysis.
Methods in molecular biology (Clifton, N.J.) 1998;105():99-108.
1998: David A Fruman; R E Meyers; Lewis C Cantley
Phosphoinositide kinases.
Annual review of biochemistry 1998;67():481-507.
1998: Zhou Songyang; Lewis C Cantley
The use of peptide library for the determination of kinase peptide substrates.
Methods in molecular biology (Clifton, N.J.) 1998;87():87-98.
1997: Michael B Yaffe; Katrin Rittinger; Stefano Volinia; Paul Caron; Alastair Aitken; H Leffers; Steven J Gamblin; Stephen John Smerdon; Lewis C Cantley
The structural basis for 14-3-3:phosphopeptide binding specificity.
Cell 1997;91(7):961-71.
1997: ML Lupher; Zhou Songyang; Steven E Shoelson; Lewis C Cantley; Hamid Band
The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.
The Journal of biological chemistry 1997;272(52):33140-4.
1997: Michael B Yaffe; Mike Schutkowski; M Shen; Xiao Zhen Zhou; P Todd Stukenberg; JU Rahfeld; J Xu; Jian Kuang; Marc W Kirschner; Gunter Fischer; Lewis C Cantley; Kun Ping Lu
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.
Science (New York, N.Y.) 1997;278(5345):1957-60.
1997: Lucia E Rameh; Kimberley F Tolias; Brian Duckworth; Lewis C Cantley
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
Nature 1997;390(6656):192-6.
1997: Brian Duckworth; Lewis C Cantley
Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength.
The Journal of biological chemistry 1997;272(44):27665-70.
1997: Zhou Songyang; David Baltimore; Lewis C Cantley; D R Kaplan; T F Franke
Interleukin 3-dependent survival by the Akt protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11345-50.
1997: Lucia E Rameh; Kermit L Carraway; A D Couvillon; G Rathbun; A Crompton; B VanRenterghem; Michael P Czech; Kodi S Ravichandran; Steven J Burakoff; D S Wang; C S Chen; A k Arvidsson; Lewis C Cantley
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.
The Journal of biological chemistry 1997;272(35):22059-66.
1997: D Grabs; Vladimir Slepnev; Zhou Songyang; C David; M Lynch; Lewis C Cantley; Pietro De Camilli
The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.
The Journal of biological chemistry 1997;272(20):13419-25.
1997: K Wong; Lewis C Cantley
Subcellular locations of phosphatidylinositol 4-kinase isoforms.
The Journal of biological chemistry 1997;272(20):13236-41.
1997: Iris Rapoport; M Miyazaki; Werner Boll; Brian Duckworth; Lewis C Cantley; Steven E Shoelson; Tomas Kirchhausen
Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.
The EMBO journal 1997;16(9):2240-50.
1997: M P Derman; Alex Toker; John H Hartwig; Katherine C Spokes; J R Falck; C S Chen; Lewis C Cantley; Lloyd G Cantley
The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.
The Journal of biological chemistry 1997;272(10):6465-70.
1997: R Meyers; Lewis C Cantley
Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase.
The Journal of biological chemistry 1997;272(7):4384-90.
1997: K Nishikawa; A Toker; F J Johannes; Zhou Songyang; Lewis C Cantley
Determination of the specific substrate sequence motifs of protein kinase C isozymes.
The Journal of biological chemistry 1997;272(2):952-60.
1997: Zhou Songyang; Alan S Fanning; C Fu; J Xu; Shirin Marfatia; Athar H Chishti; A Crompton; A C Chan; James M Anderson; Lewis C Cantley
Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.
Science (New York, N.Y.) 1997;275(5296):73-7.
1997: Lewis C Cantley; Zhou Songyang
Specificity in protein-tyrosine kinase signaling.
Advances in second messenger and phosphoprotein research 1997;31():41-8.
1996: Miikka Vikkula; L M Boon; Kermit L Carraway; J T Calvert; A J Diamonti; B Goumnerov; K A Pasyk; Douglas A Marchuk; Matthew L Warman; Lewis C Cantley; J B Mulliken; Bjorn R Olsen
Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.
Cell 1996;87(7):1181-90.
1996: John H Hartwig; S Kung; Tibor J Kovacsovics; P A Janmey; Lewis C Cantley; Thomas P Stossel; A Toker
D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate.
The Journal of biological chemistry 1996;271(51):32986-93.
1996: Werner Boll; H Ohno; Zhou Songyang; Iris Rapoport; Lewis C Cantley; Juan Bonifacino; Tomas Kirchhausen
Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.
The EMBO journal 1996;15(21):5789-95.
1996: Zhou Songyang; K P Lu; Yong Tae Kwon; Li-Huei Tsai; O Filhol; C Cochet; D A Brickey; Thomas R Soderling; Cheryl Bartleson; Donald J Graves; AJ DeMaggio; MF Hoekstra; J Blenis; Tony Hunter; Lewis C Cantley
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.
Molecular and cellular biology 1996;16(11):6486-93.
1996: David A Fruman; Lewis C Cantley; Christopher L Carpenter
Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene.
Genomics 1996;37(1):113-21.
1996: Christopher L Carpenter; Lewis C Cantley
Phosphoinositide 3-kinase and the regulation of cell growth.
Biochimica et biophysica acta 1996;1288(1):M11-6.
1996: Christopher L Carpenter; Lewis C Cantley
Phosphoinositide kinases.
Current opinion in cell biology 1996;8(2):153-8.
1996: C Bachelot; Lucia E Rameh; T Parsons; Lewis C Cantley
Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts.
Biochimica et biophysica acta 1996;1311(1):45-52.
1996: Stephen Soltoff; Lewis C Cantley
p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells.
The Journal of biological chemistry 1996;271(1):563-7.
1995: A Toker; C Bachelot; C S Chen; J R Falck; John H Hartwig; Lewis C Cantley; Tibor J Kovacsovics
Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase.
The Journal of biological chemistry 1995;270(49):29525-31.
1995: Lucia E Rameh; C S Chen; Lewis C Cantley
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
Cell 1995;83(5):821-30.
1995: Zhou Songyang; Gerald Gish; Geraldine Mbamalu; Tony Pawson; Lewis C Cantley
A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains.
The Journal of biological chemistry 1995;270(44):26029-32.
1995: Zhou Songyang; Lewis C Cantley
Recognition and specificity in protein tyrosine kinase-mediated signalling.
Trends in biochemical sciences 1995;20(11):470-5.
1995: R Kapeller; A Toker; Lewis C Cantley; Christopher L Carpenter
Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.
The Journal of biological chemistry 1995;270(43):25985-91.
1995: Kimberley F Tolias; Lewis C Cantley; Christopher L Carpenter
Rho family GTPases bind to phosphoinositide kinases.
The Journal of biological chemistry 1995;270(30):17656-9.
1995: Zhou Songyang; Benjamin L Margolis; M Chaudhuri; Steven E Shoelson; Lewis C Cantley
The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif.
The Journal of biological chemistry 1995;270(25):14863-6.
1995: Mordechai Liscovitch; Lewis C Cantley
Signal transduction and membrane traffic: the PITP/phosphoinositide connection.
Cell 1995;81(5):659-62.
1995: Tibor J Kovacsovics; C Bachelot; A Toker; C J Vlahos; B Duckworth; Lewis C Cantley; John H Hartwig
Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation.
The Journal of biological chemistry 1995;270(19):11358-66.
1995: P Pertile; Lewis C Cantley
Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking.
Biochimica et biophysica acta 1995;1248(2):129-34.
1995: Kermit L Carraway; Stephen Soltoff; A J Diamonti; Lewis C Cantley
Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.
The Journal of biological chemistry 1995;270(13):7111-6.
1995: P Pertile; Mordechai Liscovitch; V Chalifa; Lewis C Cantley
Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells.
The Journal of biological chemistry 1995;270(10):5130-5.
1995: Zhou Songyang; Lewis C Cantley
SH2 domain specificity determination using oriented phosphopeptide library.
Methods in enzymology 1995;254():523-35.
1994: K Wong; Lewis C Cantley
Cloning and characterization of a human phosphatidylinositol 4-kinase.
The Journal of biological chemistry 1994;269(46):28878-84.
1994: Zhou Songyang; S Blechner; N Hoagland; MF Hoekstra; H Piwnica-Worms; Lewis C Cantley
Use of an oriented peptide library to determine the optimal substrates of protein kinases.
Current biology : CB 1994;4(11):973-82.
1994: Mordechai Liscovitch; V Chalifa; P Pertile; C S Chen; Lewis C Cantley
Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.
The Journal of biological chemistry 1994;269(34):21403-6.
1994: P M Guy; J V Platko; Lewis C Cantley; Richard A Cerione; Kermit L Carraway
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(17):8132-6.
1994: R Kapeller; Lewis C Cantley
Phosphatidylinositol 3-kinase.
BioEssays : news and reviews in molecular, cellular and developmental biology 1994;16(8):565-76.
1994: Kermit L Carraway; Lewis C Cantley
A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling.
Cell 1994;78(1):5-8.
1994: Stephen Soltoff; Kermit L Carraway; S A Prigent; W G Gullick; Lewis C Cantley
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.
Molecular and cellular biology 1994;14(6):3550-8.
1994: Kermit L Carraway; Mark X Sliwkowski; Robert W Akita; J V Platko; P M Guy; A Nuijens; A J Diamonti; R L Vandlen; Lewis C Cantley; Richard A Cerione
The erbB3 gene product is a receptor for heregulin.
The Journal of biological chemistry 1994;269(19):14303-6.
1994: Mordechai Liscovitch; Lewis C Cantley
Lipid second messengers.
Cell 1994;77(3):329-34.
1994: R Kapeller; Kanteti V Prasad; Ottmar Janssen; W Hou; Brian Schaffhausen; Christopher E Rudd; Lewis C Cantley
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1994;269(3):1927-33.
1994: Lewis C Cantley; Zhou Songyang
Specificity in recognition of phosphopeptides by src-homology 2 domains.
Journal of cell science. Supplement 1994;18():121-6.
1993: Kanteti V Prasad; R Kapeller; Ottmar Janssen; H Repke; J S Duke-Cohan; Lewis C Cantley; Christopher E Rudd
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.
Molecular and cellular biology 1993;13(12):7708-17.
1993: Kodi S Ravichandran; K K Lee; Zhou Songyang; Lewis C Cantley; P Burn; Steven J Burakoff
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
Science (New York, N.Y.) 1993;262(5135):902-5.
1993: Kanteti V Prasad; R Kapeller; Ottmar Janssen; J S Duke-Cohan; H Repke; Lewis C Cantley; Christopher E Rudd
Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase).
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;342(1299):35-42.
1993: Kanteti V Prasad; Ottmar Janssen; R Kapeller; M Raab; Lewis C Cantley; Christopher E Rudd
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7366-70.
1993: Stephen Soltoff; M K McMillian; Barbara R Talamo; Lewis C Cantley
Blockade of ATP binding site of P2 purinoceptors in rat parotid acinar cells by isothiocyanate compounds.
Biochemical pharmacology 1993;45(9):1936-40.
1993: Christopher L Carpenter; K R Auger; M Chanudhuri; M Yoakim; Brian Schaffhausen; Steven E Shoelson; Lewis C Cantley
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.
The Journal of biological chemistry 1993;268(13):9478-83.
1993: Christopher L Carpenter; K R Auger; Brian Duckworth; W M Hou; Brian Schaffhausen; Lewis C Cantley
A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.
Molecular and cellular biology 1993;13(3):1657-65.
1993: X M Zhou; M J Cunha; J Epstein; R Levenson; Lewis C Cantley; Lloyd G Cantley
A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance.
The Journal of biological chemistry 1993;268(6):4126-33.
1993: M K McMillian; Stephen Soltoff; Lewis C Cantley; R Rudel; Barbara R Talamo
Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells.
British journal of pharmacology 1993;108(2):453-61.
1992: Stephen Soltoff; S L Rabin; Lewis C Cantley; D R Kaplan
Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.
The Journal of biological chemistry 1992;267(24):17472-7.
1992: Lloyd G Cantley; X M Zhou; M J Cunha; J Epstein; Lewis C Cantley
Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase.
The Journal of biological chemistry 1992;267(24):17271-8.
1992: Andrea Graziani; L E Ling; G Endemann; Christopher L Carpenter; Lewis C Cantley
Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes.
The Biochemical journal 1992;284 ( Pt 1)():39-45.
1992: K R Auger; Christopher L Carpenter; Steven E Shoelson; Helen Piwnica-Worms; Lewis C Cantley
Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro.
The Journal of biological chemistry 1992;267(8):5408-15.
1992: Stephen Soltoff; Christopher L Carpenter; K R Auger; R Kapeller; Brian Schaffhausen; Lewis C Cantley
Phosphatidylinositol-3 kinase and growth regulation.
Cold Spring Harbor symposia on quantitative biology 1992;57():75-80.
1991: R Kapeller; K S Chen; M Yoakim; Brian Schaffhausen; Jonathan M Backer; Morris F White; Lewis C Cantley; N B Ruderman
Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin.
Molecular endocrinology (Baltimore, Md.) 1991;5(6):769-77.
1991: Lyuba Varticovski; G Q Daley; P Jackson; David Baltimore; Lewis C Cantley
Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.
Molecular and cellular biology 1991;11(2):1107-13.
1991: Lewis C Cantley; K R Auger; C Carpenter; B Duckworth; Andrea Graziani; R Kapeller; S Soltoff
Oncogenes and signal transduction.
Cell 1991;64(2):281-302.
1991: G C Endemann; Andrea Graziani; Lewis C Cantley
A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase.
The Biochemical journal 1991;273(Pt 1)():63-6.
1991: L A Serunian; K R Auger; Lewis C Cantley
Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation.
Methods in enzymology 1991;198():78-87.
1990: Christopher L Carpenter; Lewis C Cantley
Phosphoinositide kinases.
Biochemistry 1990;29(51):11147-56.
1990: K Yamamoto; Andrea Graziani; C Carpenter; Lewis C Cantley; E G Lapetina
A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase.
The Journal of biological chemistry 1990;265(36):22086-9.
1990: Christopher L Carpenter; Brian Duckworth; K R Auger; B Cohen; Brian Schaffhausen; Lewis C Cantley
Purification and characterization of phosphoinositide 3-kinase from rat liver.
The Journal of biological chemistry 1990;265(32):19704-11.
1990: L A Serunian; K R Auger; Thomas M Roberts; Lewis C Cantley
Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen.
Journal of virology 1990;64(10):4718-25.
1990: N B Ruderman; R Kapeller; Morris F White; Lewis C Cantley
Activation of phosphatidylinositol 3-kinase by insulin.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(4):1411-5.
1990: Stephen Soltoff; M K McMillian; E J Cragoe; Lewis C Cantley; Barbara R Talamo
Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol.
The Journal of general physiology 1990;95(2):319-46.
1990: Stephen Soltoff; M K McMillian; James D Lechleiter; Lewis C Cantley; Barbara R Talamo
Elevation of [Ca2+]i and the activation of ion channels and fluxes by extracellular ATP and phospholipase C-linked agonists in rat parotid acinar cells.
Annals of the New York Academy of Sciences 1990;603():76-90; discussion 91-2.
1989: K R Auger; Christopher L Carpenter; Lewis C Cantley; Lyuba Varticovski
Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae.
The Journal of biological chemistry 1989;264(34):20181-4.
1989: L A Serunian; M T Haber; T Fukui; J W Kim; S G Rhee; J M Lowenstein; Lewis C Cantley
Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain.
The Journal of biological chemistry 1989;264(30):17809-15.
1989: K R Auger; L A Serunian; Stephen Soltoff; P Libby; Lewis C Cantley
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells.
Cell 1989;57(1):167-75.
1989: L E Ling; J T Schulz; Lewis C Cantley
Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells.
The Journal of biological chemistry 1989;264(9):5080-8.
1989: Stephen Soltoff; M K McMillian; Lewis C Cantley; E J Cragoe; Barbara R Talamo
Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium.
The Journal of general physiology 1989;93(2):285-319.
1988: M K McMillian; Stephen Soltoff; James D Lechleiter; Lewis C Cantley; Barbara R Talamo
Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists.
The Biochemical journal 1988;255(1):291-300.
1988: J T Schulz; Lewis C Cantley
CV-1 cell recipients of the mouse ouabain resistance gene express a ouabain-insensitive Na,K-ATPase after growth in cardioactive steroids.
The Journal of biological chemistry 1988;263(2):624-32.
1988: L A Serunian; Lewis C Cantley
Growth factor and oncogene influences on cell growth regulation.
Annals of the New York Academy of Sciences 1988;551():309-19.
1987: M K McMillian; Stephen Soltoff; Lewis C Cantley; Barbara R Talamo
Extracellular ATP elevates intracellular free calcium in rat parotid acinar cells.
Biochemical and biophysical research communications 1987;149(2):523-30.
1987: G Endemann; S N Dunn; Lewis C Cantley
Bovine brain contains two types of phosphatidylinositol kinase.
Biochemistry 1987;26(21):6845-52.