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Orazio Cantoni

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Catia Azzolini; Liana Cerioni; Mara Fiorani; Andrea Guidarelli; Orazio Cantoni
Sodium-dependent transport of ascorbic acid in U937 cell mitochondria.
Mara Fiorani; Andrea Guidarelli; Catia Azzolini; Liana Cerioni; Orazio Cantoni
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise nontoxic levels of reactive oxygen/nitrogen species.
Liana Cerioni; Mara Fiorani; Catia Azzolini; Orazio Cantoni
A moderate decline in U937 cell GSH levels triggers PI3 kinase/Akt-dependent Bad phosphorylation, thereby preventing an otherwise prompt apoptotic response.

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All Publications

2013: Catia Azzolini; Liana Cerioni; Mara Fiorani; Andrea Guidarelli; Orazio Cantoni
Sodium-dependent transport of ascorbic acid in U937 cell mitochondria.
IUBMB life 2013;65(2):149-53.
2013: Mara Fiorani; Andrea Guidarelli; Catia Azzolini; Liana Cerioni; Orazio Cantoni
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise nontoxic levels of reactive oxygen/nitrogen species.
The Journal of nutritional biochemistry 2013;24(2):467-74.
2012: Liana Cerioni; Mara Fiorani; Catia Azzolini; Orazio Cantoni
A moderate decline in U937 cell GSH levels triggers PI3 kinase/Akt-dependent Bad phosphorylation, thereby preventing an otherwise prompt apoptotic response.
Pharmacological research : the official journal of the Italian Pharmacological Society 2012;65(3):379-86.
2012: Catia Azzolini; Mara Fiorani; Andrea Guidarelli; Orazio Cantoni
Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells.
The British journal of nutrition 2012;107(5):691-6.
2010: Andrea Guidarelli; Mara Fiorani; Catia Azzolini; Orazio Cantoni
A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA.
Antioxidants & redox signaling 2010;13(6):745-56.
2010: Letizia Palomba; Liana Cerioni; Orazio Cantoni
Arachidonic acid inhibits neuronal nitric oxide synthase elicited by proinflammatory stimuli and promotes astrocyte survival with both exogenous and endogenous peroxynitrite via different mechanisms.
Journal of neuroscience research 2010;88(11):2459-68.
2010: Mara Fiorani; Andrea Guidarelli; Manuela Blasa; Catia Azzolini; Manila Candiracci; Elena Piatti; Orazio Cantoni
Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid.
The Journal of nutritional biochemistry 2010;21(5):397-404.
2010: Giovanni Airoldi; Andrea Guidarelli; Orazio Cantoni; Chris Panzeri; Chiara Vantaggiato; Sara Bonato; Maria Grazia D'Angelo; sestina Falcone; Clara De Palma; Alessandra Tonelli; Claudia Crimella; Sara Bondioni; Nereo Bresolin; Emilio Clementi; Maria Teresa Bassi
Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin.
Neurogenetics 2010;11(1):91-100.
2010: Liana Cerioni; Orazio Cantoni
Assessing Bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity.
Methods in molecular biology (Clifton, N.J.) 2010;648():291-301.
2009: Letizia Palomba; Liana Cerioni; Orazio Cantoni
Arachidonic acid: a key molecule for astrocyte survival to peroxynitrite.
Glia 2009;57(15):1672-9.
2008: Orazio Cantoni; Andrea Guidarelli
Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants.
IUBMB life 2008;60(11):753-6.
2008: Ilaria Tommasini; Liana Cerioni; Letizia Palomba; Orazio Cantoni
Prostaglandin E2 signals monocyte/macrophage survival to peroxynitrite via protein kinase A converging in bad phosphorylation with the protein kinase C alpha-dependent pathway driven by 5-hydroxyeicosatetraenoic acid.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5637-45.
2008: Andrea Guidarelli; Letizia Palomba; Mara Fiorani; Orazio Cantoni
Susceptibility of rat astrocytes to DNA strand scission induced by activation of NADPH oxidase and collateral resistance to the effects of peroxynitrite.
Free radical biology & medicine 2008;45(4):521-9.
2008: Liana Cerioni; Orazio Cantoni
Mitochondrial H2O2 limits U937 cell survival to peroxynitrite by promoting ERK1/2 dephosphorylation.
Biochimica et biophysica acta 2008;1783(3):492-502.
2008: Orazio Cantoni; Ilaria Tommasini; Liana Cerioni
The arachidonate-dependent survival signaling preventing toxicity in monocytes/macrophages exposed to peroxynitrite.
Methods in enzymology 2008;441():73-82.
2008: Orazio Cantoni; Letizia Palomba; Tiziana Persichini; Sofia Mariotto; Hisanori Suzuki; Marco Colasanti
Pivotal role of arachidonic acid in the regulation of neuronal nitric oxide synthase activity and inducible nitric oxide synthase expression in activated astrocytes.
Methods in enzymology 2008;440():243-52.
2008: Orazio Cantoni; Andrea Guidarelli
Indirect mechanisms of DNA strand scission by peroxynitrite.
Methods in enzymology 2008;440():111-20.
2007: Letizia Palomba; Alessandra Amadori; Orazio Cantoni
Early release of arachidonic acid prevents an otherwise immediate formation of toxic levels of peroxynitrite in astrocytes stimulated with lipopolysaccharide/interferon-gamma.
Journal of neurochemistry 2007;103(3):904-13.
2007: Andrea Guidarelli; Liana Cerioni; Orazio Cantoni
Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite.
Journal of cell science 2007;120(Pt 11):1908-14.
2007: Sofia Mariotto; Ylenia Suzuki; Tiziana Persichini; Marco Colasanti; Hisanori Suzuki; Orazio Cantoni
Cross-talk between NO and arachidonic acid in inflammation.
Current medicinal chemistry 2007;14(18):1940-4.
2007: Liana Cerioni; Orazio Cantoni
ERK1/2 regulates two sequential steps promoting monocyte survival to peroxynitrite.
Journal of cellular physiology 2007;210(1):177-82.
2006: Alessandra Valerio; Annalisa Cardile; Valeria Cozzi; Renata Bracale; Laura Tedesco; Addolorata Pisconti; Letizia Palomba; Orazio Cantoni; Emilio Clementi; Salvador Moncada; Michele O Carruba; Enzo Nisoli
TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents.
The Journal of clinical investigation 2006;116(10):2791-8.
2006: Ilaria Tommasini; Andrea Guidarelli; Letizia Palomba; Liana Cerioni; Orazio Cantoni
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite.
Journal of leukocyte biology 2006;80(4):929-38.
2006: Andrea Guidarelli; Clara Sciorati; Emilio Clementi; Orazio Cantoni
Peroxynitrite mobilizes calcium ions from ryanodine-sensitive stores, a process associated with the mitochondrial accumulation of the cation and the enforced formation of species mediating cleavage of genomic DNA.
Free radical biology & medicine 2006;41(1):154-64.
2006: Tiziana Persichini; Orazio Cantoni; Hisanori Suzuki; Marco Colasanti
Cross-talk between constitutive and inducible NO synthase: an update.
Antioxidants & redox signaling 2006;8(5-6):949-54.
2006: Liana Cerioni; Letizia Palomba; Bernhard Brüne; Orazio Cantoni
Peroxynitrite-induced mitochondrial translocation of PKCalpha causes U937 cell survival.
Biochemical and biophysical research communications 2006;339(1):126-31.
2006: Andrea Guidarelli; Mara Fiorani; Ilaria Tommasini; Liana Cerioni; Orazio Cantoni
Reduced mitochondrial formation of H(2)O(2) is responsible for resistance of dimethyl sulfoxide differentiated U937 cells to peroxynitrite.
The international journal of biochemistry & cell biology 2006;38(1):56-68.
2005: Andrea Guidarelli; Liana Cerioni; Ilaria Tommasini; Mara Fiorani; Bernhard Brüne; Orazio Cantoni
Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite.
Free radical biology & medicine 2005;39(12):1638-49.
2005: Enzo Nisoli; Cristina Tonello; Annalisa Cardile; Valeria Cozzi; Renata Bracale; Laura Tedesco; sestina Falcone; Alessandra Valerio; Orazio Cantoni; Emilio Clementi; Salvador Moncada; Michele O Carruba
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.
Science (New York, N.Y.) 2005;310(5746):314-7.
2005: Orazio Cantoni; Ilaria Tommasini; Liana Cerioni; Letizia Palomba; Elisa Carloni; Andrea Guidarelli
Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2005;142(2):118-23.
2005: Orazio Cantoni; Andrea Guidarelli; Letizia Palomba; Mara Fiorani
U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism.
Molecular pharmacology 2005;67(5):1399-405.
2005: Ilaria Tommasini; Liana Cerioni; Andrea Guidarelli; Orazio Cantoni
ERK1/2-dependent regulation of U937 cell survival after exposure to peroxynitrite.
Biochemical and biophysical research communications 2005;329(4):1282-7.
2005: Andrea Guidarelli; Liana Cerioni; Ilaria Tommasini; Bernhard Brüne; Orazio Cantoni
A downstream role for protein kinase Calpha in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells.
Biochemical pharmacology 2005;69(8):1275-86.
2004: Enzo Nisoli; sestina Falcone; Cristina Tonello; Valeria Cozzi; Letizia Palomba; Mara Fiorani; Addolorata Pisconti; Silvia Brunelli; Annalisa Cardile; Maura Francolini; Orazio Cantoni; Michele O Carruba; Salvador Moncada; Emilio Clementi
Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16507-12.
2004: Ilaria Tommasini; Piero Sestili; Andrea Guidarelli; Orazio Cantoni
Hydrogen peroxide generated at the level of mitochondria in response to peroxynitrite promotes U937 cell death via inhibition of the cytoprotective signalling mediated by cytosolic phospholipase A2.
Cell death and differentiation 2004;11(9):974-84.
2004: Letizia Palomba; Tiziana Persichini; Valeria Mazzone; Marco Colasanti; Orazio Cantoni
Inhibition of nitric-oxide synthase-I (NOS-I)-dependent nitric oxide production by lipopolysaccharide plus interferon-gamma is mediated by arachidonic acid. Effects on NFkappaB activation and late inducible NOS expression.
The Journal of biological chemistry 2004;279(29):29895-901.
2004: Ilaria Tommasini; Andrea Guidarelli; Liana Cerioni; Orazio Cantoni
The arachidonate-dependent cytoprotective signaling evoked by peroxynitrite is a general response of the monocyte/macrophage lineage.
Biochemical and biophysical research communications 2004;316(4):1191-5.
2004: Ilaria Tommasini; Orazio Cantoni
Dexamethasone promotes toxicity in U937 cells exposed to otherwise nontoxic concentrations of peroxynitrite: pivotal role for lipocortin 1-mediated inhibition of cytosolic phospholipase A2.
Molecular pharmacology 2004;65(4):964-72.
2004: Ilaria Tommasini; Andrea Guidarelli; Orazio Cantoni
Non-toxic concentrations of peroxynitrite commit U937 cells to mitochondrial permeability transition-dependent necrosis that is however prevented by endogenous arachidonic acid.
Biochemical pharmacology 2004;67(6):1077-87.
2004: Andrea Guidarelli; Mara Fiorani; Orazio Cantoni
Enhancing effects of intracellular ascorbic acid on peroxynitrite-induced U937 cell death are mediated by mitochondrial events resulting in enhanced sensitivity to peroxynitrite-dependent inhibition of complex III and formation of hydrogen peroxide.
The Biochemical journal 2004;378(Pt 3):959-66.
2004: Letizia Palomba; Marzia Bianchi; Tiziana Persichini; Mauro Magnani; Marco Colasanti; Orazio Cantoni
Downregulation of nitric oxide formation by cytosolic phospholipase A2-released arachidonic acid.
Free radical biology & medicine 2004;36(3):319-29.
2003: Mara Fiorani; Augusto Accorsi; Orazio Cantoni
Human red blood cells as a natural flavonoid reservoir.
Free radical research 2003;37(12):1331-8.
2003: Liana Cerioni; Letizia Palomba; Orazio Cantoni
The Raf/MEK inhibitor PD98059 enhances ERK1/2 phosphorylation mediated by peroxynitrite via enforced mitochondrial formation of reactive oxygen species.
FEBS letters 2003;547(1-3):92-6.
2002: Ilaria Tommasini; Piero Sestili; Andrea Guidarelli; Orazio Cantoni
Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death.
Cell death and differentiation 2002;9(12):1368-76.
2002: Giorgio Venturini; Marco Colasanti; Tiziana Persichini; Emanuela Fioravanti; Paolo Ascenzi; Letizia Palomba; Orazio Cantoni; Giovanni Musci
Beta-amyloid inhibits NOS activity by subtracting NADPH availability.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1970-2.
2002: Rico Barsacchi; Cristiana Perrotta; Piero Sestili; Orazio Cantoni; Salvador Moncada; Emilio Clementi
Cyclic GMP-dependent inhibition of acid sphingomyelinase by nitric oxide: an early step in protection against apoptosis.
Cell death and differentiation 2002;9(11):1248-55.
2002: Orazio Cantoni; Letizia Palomba; Andrea Guidarelli; Ilaria Tommasini; Liana Cerioni; Piero Sestili
Cell signaling and cytotoxicity by peroxynitrite.
Environmental health perspectives 2002;110 Suppl 5():823-5.
2002: Andrea Guidarelli; Orazio Cantoni
Pivotal role of superoxides generated in the mitochondrial respiratory chain in peroxynitrite-dependent activation of phospholipase A2.
The Biochemical journal 2002;366(Pt 1):307-14.
2002: Piero Sestili; Giuseppe Diamantini; Annalida Bedini; Liana Cerioni; Ilaria Tommasini; Giorgio Tarzia; Orazio Cantoni
Plant-derived phenolic compounds prevent the DNA single-strand breakage and cytotoxicity induced by tert-butylhydroperoxide via an iron-chelating mechanism.
The Biochemical journal 2002;364(Pt 1):121-8.
2002: Ilaria Tommasini; Piero Sestili; Orazio Cantoni
Delayed formation of hydrogen peroxide mediates the lethal response evoked by peroxynitrite in U937 cells.
Molecular pharmacology 2002;61(4):870-8.
2001: Andrea Guidarelli; Emilio Clementi; C De Nadai; R Bersacchi; Orazio Cantoni
TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation.
Experimental cell research 2001;270(1):56-65.
2001: Letizia Palomba; Andrea Guidarelli; Anna Scovassi; Orazio Cantoni
Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity.
European journal of biochemistry / FEBS 2001;268(20):5223-8.
2001: Letizia Palomba; Piero Sestili; Orazio Cantoni
tert-Butylhydroperoxide induces peroxynitrite-dependent mitochondrial permeability transition leading PC12 cells to necrosis.
Journal of neuroscience research 2001;65(5):387-95.
2001: Andrea Guidarelli; Roberta De Sanctis; B Cellini; Mara Fiorani; Marina Dachà; Orazio Cantoni
Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells.
The Biochemical journal 2001;356(Pt 2):509-13.
2001: Piero Sestili; Ilaria Tommasini; Orazio Cantoni
Peroxynitrite promotes mitochondrial permeability transition-dependent rapid U937 cell necrosis: survivors proliferate with kinetics superimposable on those of untreated cells.
Free radical research 2001;34(5):513-27.
2000: Andrea Guidarelli; Mara Fiorani; Orazio Cantoni
Calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA in U937 cells exposed to tert-butylhydroperoxide: the role of arachidonic acid.
Free radical research 2000;33(5):477-87.
2000: Letizia Palomba; Piero Sestili; Andrea Guidarelli; Clara Sciorati; Emilio Clementi; Mara Fiorani; Orazio Cantoni
Products of the phospholipase A(2) pathway mediate the dihydrorhodamine fluorescence response evoked by endogenous and exogenous peroxynitrite in PC12 cells.
Free radical biology & medicine 2000;29(8):783-9.
2000: Andrea Guidarelli; Ilaria Tommasini; Mara Fiorani; Orazio Cantoni
Essential role of the mitochondrial respiratory chain in peroxynitrite-induced strand scission of genomic DNA.
IUBMB life 2000;50(3):195-201.
2000: Andrea Guidarelli; Piero Sestili; Mara Fiorani; Orazio Cantoni
Arachidonic acid induces calcium-dependent mitochondrial formation of species promoting strand scission of genomic DNA.
Free radical biology & medicine 2000;28(11):1619-27.
2000: C De Nadai; Piero Sestili; Orazio Cantoni; JP Lièvremont; Clara Sciorati; Rico Barsacchi; Salvador Moncada; Jacopo Meldolesi; Emilio Clementi
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5480-5.
2000: Andrea Guidarelli; Letizia Palomba; Orazio Cantoni
Peroxynitrite-mediated release of arachidonic acid from PC12 cells.
British journal of pharmacology 2000;129(8):1539-41.
2000: Piero Sestili; Emilio Clementi; Andrea Guidarelli; Clara Sciorati; Orazio Cantoni
Endogenous and exogenous nitric oxide enhance the DNA strand scission induced by tert-butylhydroperoxide in PC12 cells via peroxynitrite-dependent and independent mechanisms, respectively.
The European journal of neuroscience 2000;12(1):145-54.
1999: Letizia Palomba; Piero Sestili; Marta Columbaro; Elisabetta Falcieri; Orazio Cantoni
Apoptosis and necrosis following exposure of U937 cells to increasing concentrations of hydrogen peroxide: the effect of the poly(ADP-ribose)polymerase inhibitor 3-aminobenzamide.
Biochemical pharmacology 1999;58(11):1743-50.
1999: Andrea Guidarelli; Emilio Clementi; Clara Sciorati; Orazio Cantoni
Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells.
Journal of neurochemistry 1999;73(4):1667-73.
1999: Piero Sestili; L Brambilla; Orazio Cantoni
Rotenone and pyruvate prevent the tert-butylhydroperoxide-induced necrosis of U937 cells and allow them to proliferate.
FEBS letters 1999;457(1):139-43.
1999: Letizia Palomba; Piero Sestili; Orazio Cantoni
The antioxidant butylated hydroxytoluene induces apoptosis in human U937 cells: the role of hydrogen peroxide and altered redox state.
Free radical research 1999;31(2):93-101.
1999: Andrea Guidarelli; Emilio Clementi; L Brambilla; Orazio Cantoni
NADH-Linked substrate-mediated enhancement of mitochondrial calcium accumulation and DNA single-strand breakage elicited by tert-butylhydroperoxide: the source of the cation is a ryanodine-sensitive calcium store.
Experimental cell research 1999;249(1):65-9.
1999: Piero Sestili; Orazio Cantoni
Osmotically driven radial diffusion of single-stranded DNA fragments on an agarose bed as a convenient measure of DNA strand scission.
Free radical biology & medicine 1999;26(7-8):1019-26.
1998: Andrea Guidarelli; Emilio Clementi; Clara Sciorati; Orazio Cantoni
The mechanism of the nitric oxide-mediated enhancement of tert-butylhydroperoxide-induced DNA single strand breakage.
British journal of pharmacology 1998;125(5):1074-80.
1998: Roberta Ricciarelli; Letizia Palomba; Orazio Cantoni; Angelo Azzi
3-Aminobenzamide inhibition of protein kinase C at a cellular level.
FEBS letters 1998;431(3):465-7.
1998: L Brambilla; Orazio Cantoni
Mitochondrial formation of hydrogen peroxide is causally linked to the antimycin A-mediated prevention of tert-butylhydroperoxide-induced U937 cell death.
FEBS letters 1998;431(2):245-9.
1998: Piero Sestili; Andrea Guidarelli; Marina Dachà; Orazio Cantoni
Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism.
Free radical biology & medicine 1998;25(2):196-200.
1998: Andrea Guidarelli; Piero Sestili; Orazio Cantoni
Opposite effects of nitric oxide donors on DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide.
British journal of pharmacology 1998;123(7):1311-6.
1998: L Brambilla; Piero Sestili; Andrea Guidarelli; Letizia Palomba; Orazio Cantoni
Electron transport-mediated wasteful consumption of NADH promotes the lethal response of U937 cells to tert-butylhydroperoxide.
The Journal of pharmacology and experimental therapeutics 1998;284(3):1112-21.
1998: Emilio Clementi; Andrea Guidarelli; Orazio Cantoni
The inositol 1,4,5-trisphosphate-generating agonist ATP enhances DNA cleavage induced by tert-butylhydroperoxide.
Experimental cell research 1998;239(1):175-8.
1997: Andrea Guidarelli; Emilio Clementi; L Brambilla; Orazio Cantoni
Mechanism of the antimycin A-mediated enhancement of t-butylhydroperoxide-induced single-strand breakage in DNA.
The Biochemical journal 1997;328 ( Pt 3)():801-6.
1997: L Brambilla; G Cairo; Piero Sestili; V O'Donnel; Angelo Azzi; Orazio Cantoni
Mitochondrial respiratory chain deficiency leads to overexpression of antioxidant enzymes.
FEBS letters 1997;418(3):247-50.
1997: Andrea Guidarelli; L Brambilla; Emilio Clementi; Clara Sciorati; Orazio Cantoni
Stimulation of oxygen consumption promotes mitochondrial calcium accumulation, a process associated with, and causally linked to, enhanced formation of tert-butylhydroperoxide-induced DNA single-strand breaks.
Experimental cell research 1997;237(1):176-85.
1997: Orazio Cantoni; P Giacomoni
The role of DNA damage in the cytotoxic response to hydrogen peroxide/histidine.
General pharmacology 1997;29(4):513-6.
1997: Andrea Guidarelli; Emilio Clementi; Clara Sciorati; Flaminio Nicola Cattabeni; Orazio Cantoni
Calcium-dependent mitochondrial formation of species mediating DNA single strand breakage in U937 cells exposed to sublethal concentrations of tert-butylhydroperoxide.
The Journal of pharmacology and experimental therapeutics 1997;283(1):66-74.
1997: Andrea Guidarelli; Flaminio Nicola Cattabeni; Orazio Cantoni
Alternative mechanisms for hydroperoxide-induced DNA single strand breakage.
Free radical research 1997;26(6):537-47.
1996: Letizia Palomba; L Brambilla; G Brandi; Piero Sestili; Flaminio Nicola Cattabeni; Orazio Cantoni
Low levels of hydrogen peroxide and L-histidine induce DNA double-strand breakage and apoptosis.
European journal of pharmacology 1996;318(1):167-73.
1996: Piero Sestili; Flaminio Nicola Cattabeni; Orazio Cantoni
Direct excision of 50 kb pair DNA fragments from megabase-sized fragments produced during apoptotic cleavage of genomic DNA.
FEBS letters 1996;396(2-3):337-42.
1996: Andrea Guidarelli; L Brambilla; Flaminio Nicola Cattabeni; Orazio Cantoni
Pyruvate enhances DNA single-strand break formation while abolishing cytotoxicity in U937 cells exposed to tert-butylhydroperoxide.
Biochemical and biophysical research communications 1996;226(1):70-4.
1996: Andrea Guidarelli; L Brambilla; Cristina Rota; Aldo Tomasi; Flaminio Nicola Cattabeni; Orazio Cantoni
The respiratory-chain poison antimycin A promotes the formation of DNA single-strand breaks and reduces toxicity in U937 cells exposed to t-butylhydroperoxide.
The Biochemical journal 1996;317 ( Pt 2)():371-5.
1996: Letizia Palomba; Piero Sestili; Flaminio Nicola Cattabeni; Angelo Azzi; Orazio Cantoni
Prevention of necrosis and activation of apoptosis in oxidatively injured human myeloid leukemia U937 cells.
FEBS letters 1996;390(1):91-4.
1996: Piero Sestili; G Brandi; L Brambilla; Flaminio Nicola Cattabeni; Orazio Cantoni
Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1719-25.
1996: Orazio Cantoni; Piero Sestili; Letizia Palomba; Andrea Guidarelli; Flaminio Nicola Cattabeni; D Murray
Isolation and preliminary characterization of a Chinese hamster ovary cell line with high-degree resistance to hydrogen peroxide.
Biochemical pharmacology 1996;51(8):1021-9.
1996: Piero Sestili; Andrea Guidarelli; Flaminio Nicola Cattabeni; D Murray; Orazio Cantoni
AG8 cells, which are highly resistant to hydrogen peroxide, display collateral sensitivity to the combination of hydrogen peroxide and L-histidine.
Carcinogenesis 1996;17(4):885-8.
1996: Orazio Cantoni; Piero Sestili; Andrea Guidarelli; Letizia Palomba; L Brambilla; Flaminio Nicola Cattabeni
Cytotoxic impact of DNA single vs double strand breaks in oxidatively injured cells.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1996;18():223-35.
1995: Andrea Guidarelli; Piero Sestili; A Cossarizza; C Franceschi; Flaminio Nicola Cattabeni; Orazio Cantoni
Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1575-82.
1995: Piero Sestili; Flaminio Nicola Cattabeni; Orazio Cantoni
The L-histidine-mediated enhancement of hydrogen peroxide-induced DNA double strand breakage and cytotoxicity does not involve metabolic processes.
Biochemical pharmacology 1995;50(11):1823-30.
1995: Letizia Palomba; Andrea Guidarelli; Flaminio Nicola Cattabeni; Orazio Cantoni
The effect of hydrogen peroxide/L-histidine-induced DNA single- vs. double-strand breaks on poly(ADP-ribose)polymerase.
European journal of pharmacology 1995;291(2):167-73.
1995: P Sestili; Orazio Cantoni; Flaminio Nicola Cattabeni; D Murray
Evidence for separate mechanisms of cytotoxicity in mammalian cells treated with hydrogen peroxide in the absence or presence of L-histidine.
Biochimica et biophysica acta 1995;1268(2):130-6.
1995: Piero Sestili; Flaminio Nicola Cattabeni; Orazio Cantoni
Simultaneous determination of DNA double strand breaks and DNA fragment size in cultured mammalian cells exposed to hydrogen peroxide/histidine or etoposide with CHEF electrophoresis.
Carcinogenesis 1995;16(4):703-6.
1995: Orazio Cantoni; Giorgio Brandi; A Albano; Flaminio Nicola Cattabeni
Action of cystine in the cytotoxic response of Escherichia coli cells exposed to hydrogen peroxide.
Free radical research 1995;22(3):275-83.
1994: Piero Sestili; Flaminio Nicola Cattabeni; Orazio Cantoni
The induction/loss of the oxidant-resistant phenotype of Chinese hamster ovary (CHO) cell variants does not correlate with sensitivity to DNA single strand breakage by hydrogen peroxide.
Biochemical pharmacology 1994;48(9):1701-6.
1994: Orazio Cantoni; Piero Sestili; G Brandi; Flaminio Nicola Cattabeni
The L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity is a general response in cultured mammalian cell lines and is always associated with the formation of DNA double strand breaks.
FEBS letters 1994;353(1):75-8.
1994: Orazio Cantoni; Andrea Guidarelli; Piero Sestili; Ferdinando Mannello; Giancarlo Gazzanelli; Flaminio Nicola Cattabeni
Hydrogen peroxide cytotoxicity under conditions of normal or reduced catalase activity in H2O2-sensitive and -resistant Chinese hamster ovary (CHO) cell variants.
Toxicology letters 1994;73(3):193-9.
1994: Orazio Cantoni; S Hussain; A Guidarelli; Flaminio Nicola Cattabeni
Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell variants.
Mutation research 1994;324(1-2):1-6.
1994: Orazio Cantoni; Piero Sestili; Andrea Guidarelli; Flaminio Nicola Cattabeni
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary (CHO) cell variants--II. Relationships between non-protein sulfhydryl levels and the induction/stability of the oxidant-resistant phenotype.
Biochemical pharmacology 1994;47(7):1258-61.
1994: Orazio Cantoni; Andrea Guidarelli; Piero Sestili; P U Giacomoni; Flaminio Nicola Cattabeni
L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity: relationships between DNA single/double strand breakage and cell killing.
Pharmacological research : the official journal of the Italian Pharmacological Society 1994;29(2):169-78.
1993: Orazio Cantoni; Andrea Guidarelli; Piero Sestili; Ferdinando Mannello; Giancarlo Gazzanelli; Flaminio Nicola Cattabeni
Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary cell variants--I. Relationship between catalase activity and the induction/stability of the oxidant-resistant phenotype.
Biochemical pharmacology 1993;45(11):2251-7.
1992: Piero Sestili; P U Giacomoni; Flaminio Nicola Cattabeni; Orazio Cantoni
L-glutamine prevents the L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity.
Biochemical pharmacology 1992;44(12):2418-21.
1992: Orazio Cantoni
Intra- and extracellular modifiers of the cytotoxic response to oxidative stress.
Annals of the New York Academy of Sciences 1992;663():71-3.
1992: Piero Sestili; P U Giacomoni; Andrea Guidarelli; Flaminio Nicola Cattabeni; Orazio Cantoni
Modulation of the oxidative response of cultured mammalian cells by L-histidine.
Annals of the New York Academy of Sciences 1992;663():456-7.
1992: Orazio Cantoni; Piero Sestili; Andrea Guidarelli; P U Giacomoni; Flaminio Nicola Cattabeni
Effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured mammalian cells.
Molecular pharmacology 1992;41(5):969-74.
1992: Orazio Cantoni; M Fiorani; M Mugnaini; Flaminio Nicola Cattabeni
Induction/repair of strand breakage in mature and nascent DNA of cultured Chinese hamster ovary cells exposed to hydrogen peroxide.
Journal of cancer research and clinical oncology 1992;118(8):587-90.
1992: Giorgio Brandi; L Marrot; P U Giacomoni; Piero Sestili; S Hussain; Flaminio Nicola Cattabeni; Orazio Cantoni
The role of extracellular medium components and specific amino acids in the cytotoxic response of Escherichia coli and Chinese hamster ovary cells to hydrogen peroxide.
Free radical research communications 1992;16(1):41-9.
1991: Orazio Cantoni; M Fiorani; Flaminio Nicola Cattabeni; G Bellomo
DNA breakage caused by hydrogen peroxide produced during the metabolism of 2-methyl-1,4-naphthoquinone (menadione) does not contribute to the cytotoxic action of the quinone.
Biochemical pharmacology 1991;42 Suppl():S220-2.
1991: Giorgio Brandi; L Salvaggio; Flaminio Nicola Cattabeni; Orazio Cantoni
Cytocidal and filamentous response of Escherichia coli cells exposed to low concentrations of hydrogen peroxide and hydroxyl radical scavengers.
Environmental and molecular mutagenesis 1991;18(1):22-7.
1990: Giorgio Brandi; Giuditta F Schiavano; A Albano; Flaminio Nicola Cattabeni; Orazio Cantoni
Growth delay and filamentation of Escherichia coli wild-type and Rec A cells in response to hexavalent chromium and other metal compounds.
Mutation research 1990;245(3):201-4.
1990: Piero Sestili; Giorgio Brandi; A Albano; Flaminio Nicola Cattabeni; Orazio Cantoni
The effect of histidine on the cytotoxicity of hydrogen peroxide in cultured mammalian and bacterial cells.
Pharmacological research : the official journal of the Italian Pharmacological Society 1990;22 Suppl 3():111-2.
1990: Giuditta F Schiavano; Giorgio Brandi; L Salvaggio; F C Cattabeni; Orazio Cantoni
Role of free radicals produced during the metabolism of mitomycin C in Escherichia coli inactivation.
Xenobiotica; the fate of foreign compounds in biological systems 1990;20(5):549-54.
1990: Piero Sestili; Gilberto Spadoni; C Balsamini; Anna Scovassi; Flaminio Nicola Cattabeni; E Duranti; Orazio Cantoni; D Higgins; C Thomson
Structural requirements for inhibitors of poly(ADP-ribose) polymerase.
Journal of cancer research and clinical oncology 1990;116(6):615-22.
1990: Orazio Cantoni; Piero Sestili; Flaminio Nicola Cattabeni; Cristina Geroni; FC Giuliani
Comparative effects of doxorubicin and 4'-epi-doxorubicin on nucleic acid metabolism and cytotoxicity in a human tumor cell line.
Cancer chemotherapy and pharmacology 1990;27(1):47-51.
1989: Piero Sestili; C Balsamini; Gilberto Spadoni; E Duranti; Flaminio Nicola Cattabeni; D Higgins; C Thomson; Orazio Cantoni
Substituted benzamides as poly(ADP-ribose) transferase inhibitors: development of new derivatives by using computer graphics techniques.
Pharmacological research : the official journal of the Italian Pharmacological Society 1989;21 Suppl 1():123-4.
1989: Orazio Cantoni; Flaminio Nicola Cattabeni; V Stocchi; R E Meyn; P Cerutti; D Murray
Hydrogen peroxide insult in cultured mammalian cells: relationships between DNA single-strand breakage, poly(ADP-ribose) metabolism and cell killing.
Biochimica et biophysica acta 1989;1014(1):1-7.
1989: Orazio Cantoni; Piero Sestili; M Fiorilli; M P Santoro; M C Tannoia; G Novelli; Flaminio Nicola Cattabeni; B Dallapiccola
Identification of 4 ataxia telangiectasia cell lines hypersensitive to gamma-irradiation but not to hydrogen peroxide.
Mutation research 1989;218(2):143-8.
1989: Orazio Cantoni; M Fumo; Flaminio Nicola Cattabeni
Role of metal ions in oxidant cell injury.
Biological trace element research 1989;21():277-81.
1989: Giorgio Brandi; Giuditta F Schiavano; A Albano; Flaminio Nicola Cattabeni; Orazio Cantoni
The effect of K2Cr2O7 on the growth and morphology of Escherichia coli.
Biological trace element research 1989;21():271-5.
1989: Orazio Cantoni; Piero Sestili; Flaminio Nicola Cattabeni; G Bellomo; Sovitj Pou; M Cohen; P Cerutti
Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity.
European journal of biochemistry / FEBS 1989;182(2):209-12.
1989: Orazio Cantoni; Piero Sestili; Flaminio Nicola Cattabeni; Cristina Geroni; M Grandi; FC Giuliani
Cellular and molecular pharmacology of 4'-epidoxorubicin in HeLa cells. Comparison with its parent drug, doxorubicin.
Journal of cancer research and clinical oncology 1989;115(4):373-8.
1989: Giorgio Brandi; M Fiorani; C Pierotti; A Albano; Flaminio Nicola Cattabeni; Orazio Cantoni
Morphological changes in Escherichia coli cells exposed to low or high concentrations of hydrogen peroxide.
Microbiology and immunology 1989;33(12):991-1000.
1989: Orazio Cantoni; Giorgio Brandi; Giuditta F Schiavano; A Albano; Flaminio Nicola Cattabeni
Lethality of hydrogen peroxide in wild type and superoxide dismutase mutants of Escherichia coli. (A hypothesis on the mechanism of H2O2-induced inactivation of Escherichia coli).
Chemico-biological interactions 1989;70(3-4):281-8.
1989: Orazio Cantoni; Giorgio Brandi; L Salvaggio; Flaminio Nicola Cattabeni
Molecular mechanisms of hydrogen peroxide cytotoxicity.
Annali dell'Istituto superiore di sanità 1989;25(1):69-73.
1989: Giorgio Brandi; Flaminio Nicola Cattabeni; A Albano; Orazio Cantoni
Role of hydroxyl radicals in Escherichia coli killing induced by hydrogen peroxide.
Free radical research communications 1989;6(1):47-55.
1988: Orazio Cantoni; P Sestili; Flaminio Nicola Cattabeni
Randomly distributed DNA single strand breaks are not lethal for mammalian cells.
Xenobiotica; the fate of foreign compounds in biological systems 1988;18(12):1481-7.
1988: Piero Sestili; C Balsamini; Gilberto Spadoni; Flaminio Nicola Cattabeni; Orazio Cantoni
Analogues of benzamide as poly(ADP-ribose)transferase inhibitors: a study on structure activity relationships.
Pharmacological research communications 1988;20(7):613-4.
1987: Orazio Cantoni; Piero Sestili; Gilberto Spadoni; C Balsamini; L Cucchiarini; Flaminio Nicola Cattabeni
Analogues of benzamide containing a sulfur atom as poly(ADP-ribose) transferase inhibitors.
Biochemistry international 1987;15(2):329-37.
1987: Giorgio Brandi; P Sestili; M A Pedrini; L Salvaggio; Flaminio Nicola Cattabeni; Orazio Cantoni
The effect of temperature or anoxia on Escherichia coli killing induced by hydrogen peroxide.
Mutation research 1987;190(4):237-40.