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Thomas Kipps

Research Profile

Disorders

B-Cell Chronic Lymphocytic Leukemia

Anatomy

Genes & Molecular Sequences

Chemicals & Drugs

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Publications

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M Schwaederlé; M Obara; Laura Rassenti; M L Dell' Aquila; J F Fecteau; E Ghia; Thomas Kipps
Subclonal evolution involving SF3B1 mutations in chronic lymphocytic leukemia.
V Balatti; A Bottoni; L Cascione; M J Keating; Thomas Kipps; S Lerner; Alexey Palamarchuk; yuri pekarsky; Laura Rassenti; L Rizzotto; Hansjuerg Alder; Carlo M Croce
Trisomy 12 CLLs progress through NOTCH1 mutations.
M O'Hayre; J F Fecteau; Thomas Kipps; Davorka Messmer; A C Newton; V M Nguyen; M Niederst; Tracy M Handel
Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL).

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All Publications

2013: M Schwaederlé; M Obara; Laura Rassenti; M L Dell' Aquila; J F Fecteau; E Ghia; Thomas Kipps
Subclonal evolution involving SF3B1 mutations in chronic lymphocytic leukemia.
Leukemia 2013;27(5):1214-7.
2013: V Balatti; A Bottoni; L Cascione; M J Keating; Thomas Kipps; S Lerner; Alexey Palamarchuk; yuri pekarsky; Laura Rassenti; L Rizzotto; Hansjuerg Alder; Carlo M Croce
Trisomy 12 CLLs progress through NOTCH1 mutations.
Leukemia 2013;27(3):740-3.
2012: M O'Hayre; J F Fecteau; Thomas Kipps; Davorka Messmer; A C Newton; V M Nguyen; M Niederst; Tracy M Handel
Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL).
Leukemia 2012;26(7):1689-92.
2012: Christoph Steininger; Katrina Vanura; George F Widhopf; Christopher S Morello; Rebecca Sanders; Deborah Spector; Emanuela M Ghia; Don Guiney; Ulrich Jäger; Thomas Kipps
Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen.
Blood 2012;119(10):2293-301.
2012: Suping Zhang; Li Tang; Jessica Wang-Rodriguez; Jianqiang Yu; Grzegorz W Basak; George Chen; Liguang Chen; Han-Yu Chuang; Bing Cui; Thomas Kipps
ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth.
PloS one 2012;7(3):e31127.
2011: Violaine Havelange; Thomas Kipps; Tatsuya Nakamura; Alexey Palamarchuk; yuri pekarsky; Laura Rassenti; Hansjuerg Alder; Carlo M Croce
IRF4 mutations in chronic lymphocytic leukemia.
Blood 2011;118(10):2827-9.
2010: Weizhou Zhang; Arnon P Kater; George F Widhopf; Han-Yu Chuang; Thomas Enzler; Danelle F James; Maxim Poustovoitov; Ping-Hui Tseng; Siegfried Janz; Carl Hoh; Harvey Herschman; Michael Karin; Thomas Kipps
B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18956-60.
2010: William G Wierda; J E Castro; R Aguillon; D Sampath; A Jalayer; John McMannis; C E Prussak; Michael Keating; Thomas Kipps
A phase I study of immune gene therapy for patients with CLL using a membrane-stable, humanized CD154.
Leukemia 2010;24(11):1893-900.
2010: Urmila Santanam; nicola zanesi; Alexey Efanov; Stefan Costinean; Alexey Palamarchuk; John Patrick Hagan; Stefano Volinia; Hansjuerg Alder; Laura Rassenti; Thomas Kipps; Carlo M Croce; yuri pekarsky
Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12210-5.
2010: Alexey Palamarchuk; Alexey Efanov; Natalya Nazaryan; Urmila Santanam; Hansjuerg Alder; Laura Rassenti; Thomas Kipps; Carlo M Croce; yuri pekarsky
13q14 deletions in CLL involve cooperating tumor suppressors.
Blood 2010;115(19):3916-22.
2009: Rosa Visone; Laura Rassenti; Angelo Veronese; Cristian Taccioli; Stefan Costinean; Baltazar D Aguda; Stefano Volinia; Manuela Ferracin; Jeff Palatini; Veronica Balatti; Hansjuerg Alder; Massimo Negrini; Thomas Kipps; Carlo M Croce
Karyotype-specific microRNA signature in chronic lymphocytic leukemia.
Blood 2009;114(18):3872-9.
2009: Januario E Castro; D F James; J D Sandoval-Sus; S Jain; J Bole; Laura Rassenti; Thomas Kipps
Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia.
Leukemia 2009;23(10):1779-89.
2009: Wenbin Xiao; Hong Hong; Yuko Kawakami; Yuko Kato; Dianqing Wu; Hiroki Yasudo; Akiko Kimura; Hiromi Kubagawa; Luigi F Bertoli; Randall S Davis; Luan A Chau; Joaquin Madrenas; Cyrus C Hsia; Anargyros Xenocostas; Thomas Kipps; Lothar Hennighausen; Atsushi Iwama; Hiromitsu Nakauchi; Toshiaki Kawakami
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Cancer cell 2009;16(2):161-71.
2009: Christoph Steininger; L Z Rassenti; Katrina Vanura; K Eigenberger; Ulrich Jäger; Thomas Kipps; Christine Mannhalter; Stephan Stilgenbauer; T Popow-Kraupp
Relative seroprevalence of human herpes viruses in patients with chronic lymphocytic leukaemia.
European journal of clinical investigation 2009;39(6):497-506.
2009: A M Buhl; G W Novotny; P Josefsson; J E Nielsen; L B Pedersen; C Geisler; L Z Rassenti; Thomas Kipps; J Jurlander; H Leffers
The CLLU1 expression level is a stable and inherent feature of the chronic lymphocytic leukemia clone.
Leukemia 2009;23(6):1182-6.
2009: Katherine I Lin; Constantine S Tam; Michael J Keating; William G Wierda; Susan O'Brien; Susan Lerner; Kevin R Coombes; Ellen Schlette; Alessandra Ferrajoli; Lynn L Barron; Thomas Kipps; Laura Rassenti; Stefan Faderl; Andrew Lamb; Lynne V Abruzzo
Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens.
Blood 2009;113(14):3168-71.
2009: Bradley T Messmer; Benjamin J Raphael; Sarah J Aerni; George F Widhopf; Laura Z Rassenti; John G Gribben; Neil E Kay; Thomas Kipps
Computational identification of CDR3 sequence archetypes among immunoglobulin sequences in chronic lymphocytic leukemia.
Leukemia research 2009;33(3):368-76.
2009: R Rieger; D Whitacre; M J Cantwell; C Prussak; Thomas Kipps
Chimeric form of tumor necrosis factor-alpha has enhanced surface expression and antitumor activity.
Cancer gene therapy 2009;16(1):53-64.
2008: Lingzhi Zhang; Fiona Murray; Anja Zahno; Joan R Kanter; Daisy Chou; Ryan Suda; Michael Fenlon; Laura Rassenti; Howard B Cottam; Thomas Kipps; Paul Insel
Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19532-7.
2008: J E Castro; J D Sandoval-Sus; J Bole; L Rassenti; Thomas Kipps
Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia.
Leukemia 2008;22(11):2048-53.
2008: Thomas Kipps
Genomic complexity in chronic lymphocytic leukemia.
Blood 2008;112(5):1550.
2008: Laura Z Rassenti; Sonia Jain; Michael J Keating; William G Wierda; Michael R Grever; John C Byrd; Neil E Kay; Jennifer R Brown; John G Gribben; Donna S Neuberg; Feng He; Andrew W Greaves; Kanti Rai; Thomas Kipps
Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia.
Blood 2008;112(5):1923-30.
2008: Alexander Kohlmann; Thomas Kipps; Laura Z Rassenti; James R Downing; Sheila A Shurtleff; Ken Mills; Amanda F Gilkes; Wolf-Karsten Hofmann; Giuseppe Basso; Marta Campo Dell'orto; Robin Foà; Sabina Chiaretti; John De Vos; Sonja Rauhut; Peter R Papenhausen; Jesus M Hernández; Eva Lumbreras; Allen E Yeoh; Evelyn S Koay; Rachel Li; Wei-Min Liu; Paul M Williams; Lothar Wieczorek; Torsten Haferlach
An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase.
British journal of haematology 2008;142(5):802-7.
2008: Michael Hallek; Bruce D Cheson; Daniel Catovsky; Federico Caligaris-Cappio; Guillaume Dighiero; Hartmut Döhner; Peter Hillmen; Michael J Keating; Emili Montserrat; Kanti Rai; Thomas Kipps
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines.
Blood 2008;111(12):5446-56.
2008: Emanuela M Ghia; Sonia Jain; George F Widhopf; Laura Rassenti; Michael J Keating; William G Wierda; John G Gribben; Jennifer R Brown; Kanti Rai; John C Byrd; Neil E Kay; Andrew W Greaves; Thomas Kipps
Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection.
Blood 2008;111(10):5101-8.
2008: George A Calin; Amelia Cimmino; Muller Fabbri; Manuela Ferracin; Sylwia E Wojcik; Masayoshi Shimizu; Cristian Taccioli; nicola zanesi; Ramiro Garzon; Rami I Aqeilan; Hansjuerg Alder; Stefano Volinia; Laura Rassenti; Xiuping Liu; Chang-gong liu; Thomas Kipps; Massimo Negrini; Carlo M Croce
MiR-15a and miR-16-1 cluster functions in human leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5166-71.
2008: George F Widhopf; Craig J Goldberg; Traci L Toy; Laura Rassenti; William G Wierda; John C Byrd; Michael J Keating; John G Gribben; Kanti Rai; Thomas Kipps
Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3.
Blood 2008;111(6):3137-44.
2008: Liguang Chen; Lang Huynh; John R Apgar; Li Tang; Laura Rassenti; Arthur Weiss; Thomas Kipps
ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia.
Blood 2008;111(5):2685-92.
2008: Tetsuya Fukuda; Liguang Chen; Tomoyuki Endo; Li Tang; Desheng Lu; Januario E Castro; George F Widhopf; Laura Rassenti; Mark J Cantwell; Charles E Prussak; Dennis A Carson; Thomas Kipps
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):3047-52.
2008: Apostolia-Maria Tsimberidou; William G Wierda; William Plunkett; Razelle Kurzrock; Susan O'Brien; Sijin Wen; Alessandra Ferrajoli; Farhad Ravandi-Kashani; Guillermo Garcia-Manero; Zeev Estrov; Thomas Kipps; Jennifer R Brown; Albert Fiorentino; Susan Lerner; Hagop M Kantarjian; Michael J Keating
Phase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter's syndrome or fludarabine-refractory chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(2):196-203.
2007: Thomas Kipps
Value of computed tomography in the monitoring of patients with chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(35):5556.
2007: Milena S Nicoloso; Thomas Kipps; Carlo M Croce; George A Calin
MicroRNAs in the pathogeny of chronic lymphocytic leukaemia.
British journal of haematology 2007;139(5):709-16.
2007: Gabrielle Sellick; Lynn R Goldin; Ruth W Wild; Susan L Slager; Laura Ressenti; Sara S Strom; Martin J S Dyer; Francesca Romana Mauro; Gerald E Marti; Stephen Fuller; Matthew Lyttelton; Thomas Kipps; Michael J Keating; Timothy G Call; Daniel Catovsky; Neil Caporaso; richard Houlston
A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia.
Blood 2007;110(9):3326-33.
2007: Arnon P Kater; Marinus H J van Oers; Thomas Kipps
Cellular immune therapy for chronic lymphocytic leukemia.
Blood 2007;110(8):2811-8.
2007: George A Calin; Chang-gong liu; Manuela Ferracin; Terry Hyslop; Riccardo Spizzo; Cinzia Sevignani; Muller Fabbri; Amelia Cimmino; Eun Joo Lee; Sylwia E Wojcik; Masayoshi Shimizu; Esmerina Tili; Simona Rossi; Cristian Taccioli; Flavia Pichiorri; Xiuping Liu; Simona Zupo; Vlad Herlea; Laura Gramantieri; Roberta Gafà; Hansjuerg Alder; Laura Rassenti; Stefano Volinia; Thomas D Schmittgen; Thomas Kipps; Massimo Negrini; Carlo M Croce
Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.
Cancer cell 2007;12(3):215-29.
2007: William G Wierda; Thomas Kipps
Gene therapy and active immune therapy of hematologic malignancies.
Best practice & research. Clinical haematology 2007;20(3):557-68.
2007: Thomas Kipps
The B-cell receptor and ZAP-70 in chronic lymphocytic leukemia.
Best practice & research. Clinical haematology 2007;20(3):415-24.
2007: John C Byrd; Susan O'Brien; Ian W Flinn; Thomas Kipps; Mark Weiss; Kanti Rai; Thomas S Lin; James Woodworth; Dee Wynne; Jennifer Reid; Arturo Molina; Bryan Leigh; Sarah Harris
Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 1):4448-55.
2007: Aparna Raval; Stephan M Tanner; John C Byrd; Elizabeth B Angerman; James D Perko; shih-shih chen; Björn Hackanson; Michael R Grever; David M Lucas; Jennifer J Matkovic; Thomas S Lin; Thomas Kipps; Fiona Murray; Dennis D Weisenburger; Warren G Sanger; Jane Lynch; Patrice Watson; Mary Jansen; Yuko Yoshinaga; Richard Rosenquist; Pieter J de Jong; Penny Coggill; Stephan Beck; Henry Lynch; Albert de La Chapelle; Christoph Plass
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia.
Cell 2007;129(5):879-90.
2007: Andy C Rawstron; N Villamor; Matthias Ritgen; Sebastian Böttcher; Paolo Ghia; J L Zehnder; G Lozanski; D Colomer; C Moreno; Massimo Geuna; P A S Evans; Yasodha Natkunam; S E Coutre; E D Avery; Laura Rassenti; Thomas Kipps; Federico Caligaris-Cappio; Michael Kneba; J C Byrd; Michael Hallek; E Montserrat; Peter Hillmen
International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia.
Leukemia 2007;21(5):956-64.
2007: Kazunori Kato; Peter Chu; Satoshi Takahashi; Hirofumi Hamada; Thomas Kipps
Metalloprotease inhibitors block release of soluble CD27 and enhance the immune stimulatory activity of chronic lymphocytic leukemia cells.
Experimental hematology 2007;35(3):434-42.
2007: Danelle F James; Thomas Kipps
Alemtuzumab in chronic lymphocytic leukemia.
Future oncology (London, England) 2007;3(1):29-42.
2007: Tomoyuki Endo; Mitsufumi Nishio; Thomas Enzler; Howard B Cottam; Tetsuya Fukuda; Danelle F James; Michael Karin; Thomas Kipps
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway.
Blood 2007;109(2):703-10.
2007: T Ise; Satoshi Nagata; Robert J Kreitman; Wyndham H Wilson; ALAN WAYNE; Maryalice Stetler-Stevenson; Michael Bishop; David A Scheinberg; Laura Rassenti; Thomas Kipps; R A Kyle; D F Jelinek; Ira Pastan
Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma.
Leukemia 2007;21(1):169-74.
2006: yuri pekarsky; Urmila Santanam; Amelia Cimmino; Alexey Palamarchuk; Alexey Efanov; Vadim Maximov; Stefano Volinia; Hansjuerg Alder; Chang-gong liu; Laura Rassenti; George A Calin; John Patrick Hagan; Thomas Kipps; Carlo M Croce
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181.
Cancer research 2006;66(24):11590-3.
2006: Frank Dicker; Arnon P Kater; Carlos E Prada; Tetsuya Fukuda; Januario E Castro; Guizhen Sun; Jean Y Wang; Thomas Kipps
CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53.
Blood 2006;108(10):3450-7.
2006: Laura Rassenti; Thomas Kipps
Clinical utility of assessing ZAP-70 and CD38 in chronic lymphocytic leukemia.
Cytometry. Part B, Clinical cytometry 2006;70(4):209-13.
2006: Januario E Castro; Carlos E Prada; R A Aguillon; S Kitada; Tetsuya Fukuda; M Motta; C Wu; Frank Dicker; G Sun; J Y J Wang; Dennis A Carson; J C Reed; Thomas Kipps
Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference.
Leukemia 2006;20(4):680-8.
2006: Jan A Burger; Thomas Kipps
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.
Blood 2006;107(5):1761-7.
2006: Jacques-Louis Binet; Federico Caligaris-Cappio; Daniel Catovsky; Bruce D Cheson; Tom Davis; Guillaume Dighiero; Hartmut Döhner; Michael Hallek; Peter Hillmen; Michael Keating; Emili Montserrat; Thomas Kipps; Kanti Rai
Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia.
Blood 2006;107(3):859-61.
2005: Davorka Messmer; Thomas Kipps
CD154 gene therapy for human B-cell malignancies.
Annals of the New York Academy of Sciences 2005;1062():51-60.
2005: Ian W Flinn; John C Byrd; Nancy Bartlett; Thomas Kipps; John Gribben; Deborah Thomas; Richard A Larson; Kanti Rai; Rosemary Petric; Jose Ramon-Suerez; Janice Gabrilove; Michael R Grever
Flavopiridol administered as a 24-hour continuous infusion in chronic lymphocytic leukemia lacks clinical activity.
Leukemia research 2005;29(11):1253-7.
2005: George A Calin; Manuela Ferracin; Amelia Cimmino; Gianpiero Di Leva; Masayoshi Shimizu; Sylwia E Wojcik; Marilena V Iorio; Rosa Visone; Nurettin Ilfer Sever; Muller Fabbri; Rodolfo Iuliano; Tiziana Palumbo; Flavia Pichiorri; Claudia Roldo; Ramiro Garzon; Cinzia Sevignani; Laura Rassenti; Hansjuerg Alder; Stefano Volinia; Chang-gong liu; Thomas Kipps; Massimo Negrini; Carlo M Croce
A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.
The New England journal of medicine 2005;353(17):1793-801.
2005: M Motta; Laura Rassenti; B J Shelvin; Susan Lerner; Thomas Kipps; M J Keating; William G Wierda
Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia.
Leukemia 2005;19(10):1788-93.
2005: Januario E Castro; Carlos E Prada; Olivier Loria; Mohammad Azhar Kamal; Liguang Chen; Francis J Burrows; Thomas Kipps
ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia.
Blood 2005;106(7):2506-12.
2005: Amelia Cimmino; George A Calin; Muller Fabbri; Marilena V Iorio; Manuela Ferracin; Masayoshi Shimizu; Sylwia E Wojcik; Rami I Aqeilan; Simona Zupo; Mariella Dono; Laura Rassenti; Hansjuerg Alder; Stefano Volinia; Chang-gong liu; Thomas Kipps; Massimo Negrini; Carlo M Croce
miR-15 and miR-16 induce apoptosis by targeting BCL2.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13944-9.
2005: William G Wierda; Thomas Kipps; Michael J Keating
Novel immune-based treatment strategies for chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(26):6325-32.
2005: Arnon P Kater; Frank Dicker; Massimo Mangiola; Kate Welsh; Richard A Houghten; John M Ostresh; Adel Nefzi; John C Reed; Clemencia Pinilla; Thomas Kipps
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis.
Blood 2005;106(5):1742-8.
2005: Meike Burger; Tanja Hartmann; Myriam Krome; Justyna Rawluk; Hirokazu Tamamura; Nobutaka Fujii; Thomas Kipps; Jan A Burger
Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.
Blood 2005;106(5):1824-30.
2005: Mitsufumi Nishio; Tomoyuki Endo; Nobuhiro Tsukada; Junko Ohata; Shinichi Kitada; John C Reed; Nathan J Zvaifler; Thomas Kipps
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha.
Blood 2005;106(3):1012-20.
2005: Aparna Raval; David M Lucas; Jennifer J Matkovic; Kristi L Bennett; Sandya Liyanarachchi; Donn C Young; Laura Rassenti; Thomas Kipps; Michael R Grever; John C Byrd; Christoph Plass
TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(17):3877-85.
2005: Frank Dicker; Arnon P Kater; Tetsuya Fukuda; Thomas Kipps
Fas-ligand (CD178) and TRAIL synergistically induce apoptosis of CD40-activated chronic lymphocytic leukemia B cells.
Blood 2005;105(8):3193-8.
2005: Wendelina J M Mackus; Arnon P Kater; Annette Grummels; Ludo M Evers; B Hooijbrink; Mark H H Kramer; Januario E Castro; Thomas Kipps; René A W van Lier; Marinus H J van Oers; Eric Eldering
Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation.
Leukemia 2005;19(3):427-34.
2005: Liguang Chen; John R Apgar; Lang Huynh; Frank Dicker; Teresa Giago-McGahan; Laura Rassenti; Arthur Weiss; Thomas Kipps
ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia.
Blood 2005;105(5):2036-41.
2005: Junko Ohata; Nathan J Zvaifler; Mitsufumi Nishio; David L Boyle; Susan L Kalled; Dennis A Carson; Thomas Kipps
Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):864-70.
2005: Davorka Messmer; Thomas Kipps
Treatment of solid tumors with immunotoxins.
Breast cancer research : BCR 2005;7(5):184-6.
2004: George F Widhopf; Laura Rassenti; Traci L Toy; John G Gribben; William G Wierda; Thomas Kipps
Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins.
Blood 2004;104(8):2499-504.
2004: Maher Albitar; Kim-Anh Do; Marcella M Johnson; Francis Giles; Iman Jilani; Susan O'Brien; Jorge Cortes; Deborah Thomas; Laura Rassenti; Thomas Kipps; Hagop M Kantarjian; Michael Keating
Free circulating soluble CD52 as a tumor marker in chronic lymphocytic leukemia and its implication in therapy with anti-CD52 antibodies.
Cancer 2004;101(5):999-1008.
2004: Laura Rassenti; Lang Huynh; Tracy L Toy; Liguang Chen; Michael J Keating; John G Gribben; Donna Neuberg; Ian W Flinn; Kanti Rai; John C Byrd; Neil E Kay; Andrew W Greaves; Arthur Weiss; Thomas Kipps
ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia.
The New England journal of medicine 2004;351(9):893-901.
2004: Irene M Pedersen; Juan M Zapata; Temesgen Samuel; Fiona L Scott; Guy S Salvesen; Tadashi Honda; Gordon W Gribble; Nanjoo Suh; Michael B. Sporn; Thomas Kipps; John C Reed
Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells.
Blood 2004;104(4):932.
2004: George A Calin; Chang-gong liu; Cinzia Sevignani; Manuela Ferracin; Nadia Felli; Calin Dan Dumitru; Masayoshi Shimizu; Amelia Cimmino; Simona Zupo; Mariella Dono; Marie L Dell'Aquila; Hansjuerg Alder; Laura Rassenti; Thomas Kipps; Florencia Bullrich; Massimo Negrini; Carlo M Croce
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(32):11755-60.
2004: Desheng Lu; Yandong Zhao; Rommel I Tawatao; Howard B Cottam; Malini Sen; Lorenzo Leoni; Thomas Kipps; Maripat Corr; Dennis A Carson
Activation of the Wnt signaling pathway in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3118-23.
2004: Barbara Becattini; Shinichi Kitada; Marilisa Leone; Edward Monosov; Sharon Chandler; Dayong Zhai; Thomas Kipps; John C Reed; Surya De
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).
Chemistry & biology 2004;11(3):389-95.
2004: George F Widhopf; Diana C Brinson; Thomas Kipps; Helen Tighe
Transgenic expression of a human polyreactive Ig expressed in chronic lymphocytic leukemia generates memory-type B cells that respond to nonspecific immune activation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2092-9.
2003: Meike Burger; Aleksandra Glodek; Tanja Hartmann; Annette Schmitt-Gräff; Leslie E Silberstein; Nobutaka Fujii; Thomas Kipps; Jan A Burger
Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.
Oncogene 2003;22(50):8093-101.
2003: Roman Rieger; Thomas Kipps
CpG oligodeoxynucleotides enhance the capacity of adenovirus-mediated CD154 gene transfer to generate effective B-cell lymphoma vaccines.
Cancer research 2003;63(14):4128-35.
2003: Thomas Kipps
Immunobiology of chronic lymphocytic leukemia.
Current opinion in hematology 2003;10(4):312-8.
2003: Christina C N Wu; Januario E Castro; Marina Motta; Howard B Cottam; Diego Kyburz; Thomas Kipps; Maripat Corr; Dennis A Carson
Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells.
Human gene therapy 2003;14(9):849-60.
2003: Traci E Battle; William G Wierda; Laura Rassenti; David Zahrieh; Donna Neuberg; Thomas Kipps; David A Frank
In vivo activation of signal transducer and activator of transcription 1 after CD154 gene therapy for chronic lymphocytic leukemia is associated with clinical and immunologic response.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(6):2166-72.
2003: Philip Payne; Andrew W Greaves; Thomas Kipps
CRC Clinical Trials Management System (CTMS): an integrated information management solution for collaborative clinical research.
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium 2003;():967.
2003: Andrew W Greaves; Philip Payne; Laura Rassenti; Thomas Kipps
CRC Tissue Core Management System (TCMS): integration of basic science and clinical data for translational research.
AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium 2003;():853.
2003: Michael J Keating; Nicholas Chiorazzi; Bradley T Messmer; Rajendra N Damle; Steven Allen; Kanti Rai; Manlio Ferrarini; Thomas Kipps
Biology and treatment of chronic lymphocytic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():153-75.
2002: Liguang Chen; George F Widhopf; Lang Huynh; Laura Rassenti; Kanti Rai; Arthur Weiss; Thomas Kipps
Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia.
Blood 2002;100(13):4609-14.
2002: George A Calin; Calin Dan Dumitru; Masayoshi Shimizu; Roberta Bichi; Simona Zupo; Evan Noch; Hansjuerg Aldler; Shashi Rattan; Michael Keating; Kanti Rai; Laura Rassenti; Thomas Kipps; Massimo Negrini; Florencia Bullrich; Carlo M Croce
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15524-9.
2002: Irene M Pedersen; Shinichi Kitada; Aaron D Schimmer; Youngsoo Kim; Juan M Zapata; Lula Charboneau; Laura Rassenti; Michael Andreeff; Frank Bennett; Michael B. Sporn; Lance D Liotta; Thomas Kipps; John C Reed
The triterpenoid CDDO induces apoptosis in refractory CLL B cells.
Blood 2002;100(8):2965-72.
2002: Khaled A Tolba; William J Bowers; David J Eling; Ann E Casey; Thomas Kipps; Howard Federoff; Joseph D Rosenblatt
HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(4):455-63.
2002: Irene M Pedersen; Shinichi Kitada; Lorenzo Leoni; Juan M Zapata; James G Karras; Nobuhiro Tsukada; Thomas Kipps; Yong Sung Choi; Frank Bennett; John C Reed
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.
Blood 2002;100(5):1795-801.
2002: Thomas Kipps
Immune and cell therapy of hematologic malignancies.
International journal of hematology 2002;76 Suppl 1():269-73.
2002: Asad Bashey; Mark J Cantwell; Thomas Kipps
Adenovirus transduction to effect CD40 signalling improves the immune stimulatory activity of myeloma cells.
British journal of haematology 2002;118(2):506-13.
2002: Peter Chu; Dieter Deforce; Irene M Pedersen; Youngsoo Kim; Shinichi Kitada; John C Reed; Thomas Kipps
Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3854-9.
2002: Jan A Burger; Thomas Kipps
Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells.
Leukemia & lymphoma 2002;43(3):461-6.
2002: Thomas Kipps
Advances in classification and therapy of indolent B-cell malignancies.
Seminars in oncology 2002;29(1 Suppl 2):98-104.
2002: Nobuhiro Tsukada; Jan A Burger; Nathan J Zvaifler; Thomas Kipps
Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia.
Blood 2002;99(3):1030-7.
2002: Rui-Kun Zhong; Laura Rassenti; Thomas Kipps; Jian Chen; Ping Law; Ji-Feng Yu; Edward D Ball
Sequential modulation of growth factors: a novel strategy for adoptive immunotherapy of acute myeloid leukemia.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2002;8(10):557-68.
2001: Andreas Rosenwald; A A Alizadeh; George F Widhopf; R Simon; R Eric Davis; X Yu; L Yang; Oxana Pickeral; Laura Rassenti; J Powell; D Botstein; J C Byrd; M R Grever; B D Cheson; Nicholas Chiorazzi; Wyndham H Wilson; Thomas Kipps; P O Brown; Louis M Staudt
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia.
The Journal of experimental medicine 2001;194(11):1639-47.
2001: Naoto Tamura; Shigeto Kobayashi; K Kato; H Bando; Kazuhiko Haruta; M Oyanagi; M Kuriyama; Thomas Kipps; Hiroshi Hashimoto
Soluble CD154 in rheumatoid arthritis: elevated plasma levels in cases with vasculitis.
The Journal of rheumatology 2001;28(12):2583-90.
2001: XH Hua; Davide Genini; R Gussio; Rommel I Tawatao; Hsiencheng Shih; Thomas Kipps; Dennis A Carson; Lorenzo Leoni
Biochemical genetic analysis of indanocine resistance in human leukemia.
Cancer research 2001;61(19):7248-54.
2001: Florencia Bullrich; H Fujii; George A Calin; H Mabuchi; Massimo Negrini; yuri pekarsky; Laura Rassenti; Hansjuerg Alder; J C Reed; M J Keating; Thomas Kipps; Carlo M Croce
Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene.
Cancer research 2001;61(18):6640-8.
2001: MJ Cantwell; William G Wierda; Izidore S Lossos; Ronald Levy; Thomas Kipps
T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154.
Leukemia 2001;15(9):1451-7.
2001: H Mabuchi; H Fujii; George A Calin; Hansjuerg Alder; Massimo Negrini; Laura Rassenti; Thomas Kipps; Florencia Bullrich; Carlo M Croce
Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.
Cancer research 2001;61(7):2870-7.
2001: Jan A Burger; R B Mendoza; Thomas Kipps
Plasmids encoding granulocyte-macrophage colony-stimulating factor and CD154 enhance the immune response to genetic vaccines.
Vaccine 2001;19(15-16):2181-9.
2001: Jan A Burger; Nathan J Zvaifler; Nobuhiro Tsukada; Gary S Firestein; Thomas Kipps
Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism.
The Journal of clinical investigation 2001;107(3):305-15.
2001: George F Widhopf; Thomas Kipps
Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):95-102.
2000: Thomas Kipps; P Chu; W G Wierda
Immunogenetic therapy for B-cell malignancies.
Seminars in oncology 2000;27(6 Suppl 12):104-9.
2000: William G Wierda; MJ Cantwell; S J Woods; Laura Rassenti; C E Prussak; Thomas Kipps
CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia.
Blood 2000;96(9):2917-24.
2000: Juan M Zapata; Maryla Krajewska; Stan Krajewski; Shinichi Kitada; Kate Welsh; Anne Monks; N McCloskey; J Gordon; Thomas Kipps; Randy D Gascoyne; Ahmed Shabaik; John C Reed
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5084-96.
2000: Jan A Burger; Nobuhiro Tsukada; Meike Burger; Nathan J Zvaifler; M Dell'Aquila; Thomas Kipps
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.
Blood 2000;96(8):2655-63.
2000: W G Wierda; Thomas Kipps
Gene therapy of hematologic malignancies.
Seminars in oncology 2000;27(5):502-11.
2000: David J Eling; P A Johnson; S Sharma; F Tufaro; Thomas Kipps
Chronic lymphocytic leukemia B cells are highly sensitive to infection by herpes simplex virus-1 via herpesvirus-entry-mediator A.
Gene therapy 2000;7(14):1210-6.
2000: M A Spear; F Sun; David J Eling; E Gilpin; Thomas Kipps; E A Chiocca; Michael Bouvet
Cytotoxicity, apoptosis, and viral replication in tumor cells treated with oncolytic ribonucleotide reductase-defective herpes simplex type 1 virus (hrR3) combined with ionizing radiation.
Cancer gene therapy 2000;7(7):1051-9.
2000: Thomas Kipps
Chronic lymphocytic leukemia.
Current opinion in hematology 2000;7(4):223-34.
2000: P Chu; W G Wierda; Thomas Kipps
CD40 activation does not protect chronic lymphocytic leukemia B cells from apoptosis induced by cytotoxic T lymphocytes.
Blood 2000;95(12):3853-8.
2000: Thomas Kipps
Genetics of chronic lymphocytic leukaemia.
Hematology and cell therapy 2000;42(1):5-14.
2000: Laura Rassenti; Thomas Kipps
Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion.
Blood 2000;95(8):2725-7.
2000: Jan A Burger; S M Baird; H C Powell; S Sharma; David J Eling; Thomas Kipps
Local and systemic effects after adenoviral transfer of the murine granulocyte-macrophage colony-stimulating factor gene into mice.
British journal of haematology 2000;108(3):641-52.
2000: Jiri Kovarik; Xavier Martinez; Maria Pihlgren; Paola Bozzotti; M H Tao; Thomas Kipps; T F Wild; Paul-Henri Lambert; Claire-Anne Siegrist
Limitations of in vivo IL-12 supplementation strategies to induce Th1 early life responses to model viral and bacterial vaccine antigens.
Virology 2000;268(1):122-31.
2000: Thomas Kipps
Genetic engineering strategies for hematologic malignancies.
Genetic engineering 2000;22():197-207.
1999: Jan A Burger; M Burger; Thomas Kipps
Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.
Blood 1999;94(11):3658-67.
1999: Thomas Kipps
Future strategies toward the cure of indolent B-cell malignancies. Molecular genetic approaches.
Seminars in hematology 1999;36(4 Suppl 5):3-8.
1999: K Kato; E Santana-Sahagún; L Z Rassenti; M H Weisman; N Tamura; S Kobayashi; H Hashimoto; Thomas Kipps
The soluble CD40 ligand sCD154 in systemic lupus erythematosus.
The Journal of clinical investigation 1999;104(7):947-55.
1999: D Hu; Thomas Kipps
Reduction in mitochondrial membrane potential is an early event in Fas-independent CTL-mediated apoptosis.
Cellular immunology 1999;195(1):43-52.
1999: W G Wierda; Thomas Kipps
Chronic lymphocytic leukemia.
Current opinion in hematology 1999;6(4):253-61.
1999: Florencia Bullrich; D Rasio; Shinichi Kitada; P Starostik; Thomas Kipps; M Keating; M Albitar; J C Reed; Carlo M Croce
ATM mutations in B-cell chronic lymphocytic leukemia.
Cancer research 1999;59(1):24-7.
1998: Franco Fais; Fabio Ghiotto; S Hashimoto; B Sellars; Angelo Valetto; Steven Allen; Philip Schulman; Vincent P Vinciguerra; Kanti Rai; Laura Rassenti; Thomas Kipps; Guillaume Dighiero; Harry Schroeder; Manlio Ferrarini; Nicholas Chiorazzi
Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.
The Journal of clinical investigation 1998;102(8):1515-25.
1998: A Bessudo; Laura Rassenti; Diane V Havlir; Douglas Richman; E Feigal; Thomas Kipps
Aberrant and unstable expression of immunoglobulin genes in persons infected with human immunodeficiency virus.
Blood 1998;92(4):1317-23.
1998: Thomas Kipps
Chronic lymphocytic leukemia.
Current opinion in hematology 1998;5(4):244-53.
1998: Y Chen; D Hu; David J Eling; J Robbins; Thomas Kipps
DNA vaccines encoding full-length or truncated Neu induce protective immunity against Neu-expressing mammary tumors.
Cancer research 1998;58(9):1965-71.
1998: K Kato; MJ Cantwell; S Sharma; Thomas Kipps
Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells.
The Journal of clinical investigation 1998;101(5):1133-41.
1997: Y Wu; Thomas Kipps
Deoxyribonucleic acid vaccines encoding antigens with rapid proteasome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6037-43.
1997: R B Mendoza; M J Cantwell; Thomas Kipps
Immunostimulatory effects of a plasmid expressing CD40 ligand (CD154) on gene immunization.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5777-81.
1997: Thomas Kipps
Signal transduction pathways and mechanisms of apoptosis in CLL B-lymphocytes: their role in CLL pathogenesis.
Hematology and cell therapy 1997;39 Suppl 1():S17-27.
1997: M J Cantwell; T Hua; N J Zvaifler; Thomas Kipps
Deficient Fas ligand expression by synovial lymphocytes from patients with rheumatoid arthritis.
Arthritis and rheumatism 1997;40(9):1644-52.
1997: M Cantwell; T Hua; J Pappas; Thomas Kipps
Acquired CD40-ligand deficiency in chronic lymphocytic leukemia.
Nature medicine 1997;3(9):984-9.
1997: Thomas Kipps
Chronic lymphocytic leukemia.
Current opinion in hematology 1997;4(4):268-76.
1997: Laura Rassenti; Thomas Kipps
Lack of allelic exclusion in B cell chronic lymphocytic leukemia.
The Journal of experimental medicine 1997;185(8):1435-45.
1997: Eric H Sasso; T Johnson; Thomas Kipps
Expression of an Ig VH gene, 51p1, is proportional to its germline gene copy number.
Annals of the New York Academy of Sciences 1997;815():478-80.
1997: Thomas Kipps
Human B cell biology.
International reviews of immunology 1997;15(3-4):243-64.
1997: T A Johnson; Laura Rassenti; Thomas Kipps
Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):235-46.
1996: H Kohsaka; Dennis A Carson; Laura Rassenti; W E Ollier; Pojen P Chen; Thomas Kipps; N Miyasaka
The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation.
The Journal of clinical investigation 1996;98(12):2794-800.
1996: M J Cantwell; S Sharma; T Friedmann; Thomas Kipps
Adenovirus vector infection of chronic lymphocytic leukemia B cells.
Blood 1996;88(12):4676-83.
1996: T C Fong; Y Wu; Thomas Kipps
Identification of a promoter element that regulates tissue-specific expression of the human CD80 (B7.1) gene.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(10):4442-50.
1996: S Sharma; M Cantwell; Thomas Kipps; Theodore Friedmann
Efficient infection of a human T-cell line and of human primary peripheral blood leukocytes with a pseudotyped retrovirus vector.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11842-7.
1996: A Bessudo; V Cherepakhin; T A Johnson; Laura Rassenti; E Feigal; Thomas Kipps
Favored use of immunoglobulin V(H)4 Genes in AIDS-associated B-cell lymphoma.
Blood 1996;88(1):252-60.
1995: Laura Rassenti; H Kohsaka; Thomas Kipps
Analysis of immunoglobulin VH gene repertoire by an anchored PCR-ELISA.
Annals of the New York Academy of Sciences 1995;764():463-73.
1995: A Bessudo; Thomas Kipps
Origin of high-grade lymphomas in Richter syndrome.
Leukemia & lymphoma 1995;18(5-6):367-72.
1995: E A Ranheim; M J Cantwell; Thomas Kipps
Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells.
Blood 1995;85(12):3556-65.
1995: E A Ranheim; Thomas Kipps
Tumor necrosis factor-alpha facilitates induction of CD80 (B7-1) and CD54 on human B cells by activated T cells: complex regulation by IL-4, IL-10, and CD40L.
Cellular immunology 1995;161(2):226-35.
1994: T B Parr; T A Johnson; L E Silberstein; Thomas Kipps
Anti-B cell autoantibodies encoded by VH 4-21 genes in human fetal spleen do not require in vivo somatic selection.
European journal of immunology 1994;24(12):2941-9.
1994: E A Ranheim; Thomas Kipps
Elevated expression of CD80 (B7/BB1) and other accessory molecules on synovial fluid mononuclear cell subsets in rheumatoid arthritis.
Arthritis and rheumatism 1994;37(11):1637-46.
1994: M Lotz; E Ranheim; Thomas Kipps
Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells.
The Journal of experimental medicine 1994;179(3):999-1004.
1993: R Kobayashi; Laura Rassenti; Grant Meisenholder; Dennis A Carson; Thomas Kipps
Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):7273-83.
1993: V Cherepakhin; S M Baird; Grant Meisenholder; Thomas Kipps
Common clonal origin of chronic lymphocytic leukemia and high-grade lymphoma of Richter's syndrome.
Blood 1993;82(10):3141-7.
1993: A Watanabe; Eyal Raz; H Kohsaka; Helen Tighe; S M Baird; Thomas Kipps; Dennis A Carson
Induction of antibodies to a kappa V region by gene immunization.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2871-6.
1993: Eyal Raz; A Watanabe; S M Baird; R A Eisenberg; T B Parr; Martin Lotz; Thomas Kipps; Dennis A Carson
Systemic immunological effects of cytokine genes injected into skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4523-7.
1993: Thomas Kipps; Dennis A Carson
Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases.
Blood 1993;81(10):2475-87.
1993: E A Ranheim; Thomas Kipps
Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.
The Journal of experimental medicine 1993;177(4):925-35.
1993: Laura Rassenti; Thomas Kipps
Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia.
The Journal of experimental medicine 1993;177(4):1039-46.
1993: H Kawasaki; CJ Carrera; Lawrence D Piro; Alan Saven; Thomas Kipps; Dennis A Carson
Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine.
Blood 1993;81(3):597-601.
1993: Helen Tighe; Pojen P Chen; R Tucker; Thomas Kipps; Jean Roudier; F R Jirik; Dennis A Carson
Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice.
The Journal of experimental medicine 1993;177(1):109-18.
1993: Thomas Kipps
Immunoglobulin genes in chronic lymphocytic leukemia.
Blood cells 1993;19(3):615-25; discussion 631-2.
1992: R Kobayashi; Gastón R Picchio; M Kirven; Grant Meisenholder; S Baird; Dennis A Carson; Donald E Mosier; Thomas Kipps
Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency.
Leukemia research 1992;16(10):1013-23.
1992: Donald E Mosier; Gastón R Picchio; S M Baird; R Kobayashi; Thomas Kipps
Epstein-Barr virus-induced human B-cell lymphomas in SCID mice reconstituted with human peripheral blood leukocytes.
Cancer research 1992;52(19 Suppl):5552s-5553s.
1992: C Grillot-Courvalin; Jean-Claude Brouet; F Piller; Laura Rassenti; Sylvaine Labaume; G J Silverman; L Silberstein; Thomas Kipps
An anti-B cell autoantibody from Wiskott-Aldrich syndrome which recognizes i blood group specificity on normal human B cells.
European journal of immunology 1992;22(7):1781-8.
1992: Thomas Kipps; Grant Meisenholder; B A Robbins
New developments in flow cytometric analyses of lymphocyte markers.
Clinics in laboratory medicine 1992;12(2):237-75.
1992: Thomas Kipps; Laura Rassenti; S Duffy; T Johnson; R Kobayashi; Dennis A Carson
Immunoglobulin V gene expression in CD5 B-cell malignancies.
Annals of the New York Academy of Sciences 1992;651():373-83.
1992: Donald E Mosier; Gastón R Picchio; M B Kirven; J L Garnier; Bruce E Torbett; S M Baird; R Kobayashi; Thomas Kipps
EBV-induced human B cell lymphomas in hu-PBL-SCID mice.
AIDS research and human retroviruses 1992;8(5):735-40.
1992: Gastón R Picchio; R Kobayashi; M Kirven; S M Baird; Thomas Kipps; Donald E Mosier
Heterogeneity among Epstein-Barr virus-seropositive donors in the generation of immunoblastic B-cell lymphomas in SCID mice receiving human peripheral blood leukocyte grafts.
Cancer research 1992;52(9):2468-77.
1992: Dennis A Carson; D B Wasson; L M Esparza; CJ Carrera; Thomas Kipps; Howard B Cottam
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2970-4.
1991: L F Pratt; R Szubin; Dennis A Carson; Thomas Kipps
Molecular characterization of a supratypic cross-reactive idiotype associated with IgM autoantibodies.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):2041-6.
1991: Laura Rassenti; L F Pratt; Pojen P Chen; Dennis A Carson; Thomas Kipps
Autoantibody-encoding kappa L chain genes frequently rearranged in lambda L chain-expressing chronic lymphocytic leukemia.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):1060-6.
1991: Thomas Kipps; S F Duffy
Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypes.
The Journal of clinical investigation 1991;87(6):2087-96.
1991: O Axelrod; Gregg J Silverman; V Dev; R Kyle; Dennis A Carson; Thomas Kipps
Idiotypic cross-reactivity of immunoglobulins expressed in Waldenström's macroglobulinemia, chronic lymphocytic leukemia, and mantle zone lymphocytes of secondary B-cell follicles.
Blood 1991;77(7):1484-90.
1991: Dennis A Carson; Pojen P Chen; Thomas Kipps
New roles for rheumatoid factor.
The Journal of clinical investigation 1991;87(2):379-83.
1991: Dennis A Carson; Pojen P Chen; Gregg J Silverman; Thomas Kipps
Immunoglobulin gene expression in systemic rheumatic diseases.
British journal of rheumatology 1991;30 Suppl 1():43-6.
1990: Thomas Kipps; B A Robbins; A Tefferi; Grant Meisenholder; P M Banks; Dennis A Carson
CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies.
The American journal of pathology 1990;136(4):809-16.
1990: Jean Roudier; Gregg J Silverman; Pojen P Chen; Dennis A Carson; Thomas Kipps
Intraclonal diversity in the VH genes expressed by CD5- chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1526-30.
1990: Thomas Kipps
Immunoglobulin idiotypes in human B cell neoplasia. Implications for pathogenesis and therapy.
Chemical immunology 1990;48():167-84.
1990: Donald E Mosier; S M Baird; M B Kirven; Rick gulizia; D B Wilson; R Kubayashi; Gastón R Picchio; J L Garnier; J L Sullivan; Thomas Kipps
EBV-associated B-cell lymphomas following transfer of human peripheral blood lymphocytes to mice with severe combined immune deficiency.
Current topics in microbiology and immunology 1990;166():317-23.
1990: Thomas Kipps; B A Robbins; Dennis A Carson
Uniform high frequency expression of autoantibody-associated crossreactive idiotypes in the primary B cell follicles of human fetal spleen.
The Journal of experimental medicine 1990;171(1):189-96.
1989: Dennis A Carson; Pojen P Chen; Thomas Kipps; Jean Roudier; Gregg J Silverman; Helen Tighe
Regulation of rheumatoid factor synthesis.
Clinical and experimental rheumatology 1989;7 Suppl 3():S69-73.
1989: Thomas Kipps; E Tomhave; L F Pratt; S Duffy; Pojen P Chen; Dennis A Carson
Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5913-7.
1989: L F Pratt; Laura Rassenti; J Larrick; B Robbins; P M Banks; Thomas Kipps
Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):699-705.
1989: Thomas Kipps; E Tomhave; Pojen P Chen; R I Fox
Molecular characterization of a major autoantibody-associated cross-reactive idiotype in Sjogren's syndrome.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4261-8.
1989: M F Liu; D L Robbins; J J Crowley; S Sinha; F Kozin; Thomas Kipps; Dennis A Carson; Pojen P Chen
Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):688-94.
1989: Donald E Mosier; Rick gulizia; S M Baird; S Spector; D Spector; Thomas Kipps; R I Fox; D A Carson; N Cooper; D D Richman
Studies of HIV infection and the development of Epstein-Barr virus-related B cell lymphomas following transfer of human lymphocytes to mice with severe combined immunodeficiency.
Current topics in microbiology and immunology 1989;152():195-9.
1989: Thomas Kipps
The CD5 B cell.
Advances in immunology 1989;47():117-85.
1988: Thomas Kipps; E Tomhave; Pojen P Chen; Dennis A Carson
Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.
The Journal of experimental medicine 1988;167(3):840-52.
1988: Thomas Kipps
Immunoglobulin V gene utilization in chronic lymphocytic leukemia and non-Hodgkin's B cell lymphomas.
Nouvelle revue française d'hématologie 1988;30(5-6):293-8.
1987: Dennis A Carson; Pojen P Chen; Thomas Kipps; V Radoux; F R Jirik; R D Goldfien; R I Fox; Gregg J Silverman; S Fong
Idiotypic and genetic studies of human rheumatoid factors.
Arthritis and rheumatism 1987;30(12):1321-5.
1987: Pojen P Chen; K Albrandt; Thomas Kipps; V Radoux; Fu-Tong Liu; Dennis A Carson
Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(5):1727-33.
1987: Thomas Kipps; S Fong; E Tomhave; Pojen P Chen; R D Goldfien; Dennis A Carson
High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(9):2916-20.
1987: R D Goldfien; P J Chen; Thomas Kipps; G Starkebaum; J G Heitzmann; V Radoux; S Fong; Dennis A Carson
Genetic analysis of human B cell hybridomas expressing a cross-reactive idiotype.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(3):940-4.
1987: Dennis A Carson; Pojen P Chen; Thomas Kipps; V Radoux; F Jirik; R D Goldfien; R I Fox; Gregg J Silverman; S Fong
Molecular basis for the cross-reactive idiotypes on human anti-IgG autoantibodies (rheumatoid factors).
Ciba Foundation symposium 1987;129():123-34.
1987: Dennis A Carson; Pojen P Chen; R I Fox; Thomas Kipps; F Jirik; R D Goldfien; G Silverman; V Radoux; S Fong
Rheumatoid factor and immune networks.
Annual review of immunology 1987;5():109-26.