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Guoqing Cao

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Yanqun Chen; maryam ehsani; Xian-Cheng Jiang; Robert J Konrad; Ming-Shang Kuo; Yue-Wei Qian; He Wang; Lan Yu; David A Yurek; Guoqing Cao; Jian Wang
Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometry.
Jason S Troutt; Bo Angelin; Anthony M Butterfield; Guoqing Cao; Lena Persson; Mats Rudling; Andrew E Schade; Lars Ståhle; Robert J Konrad
Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administration.
Zhiqiang Li; Jing Liu; Tae-Sik Park; Ming-Shang Kuo; Yan Li; Hai H Bui; Guoqing Cao; Yifan Fan; Chongmin Huan; Xian-Cheng Jiang
Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice.

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All Publications

2013: Yanqun Chen; maryam ehsani; Xian-Cheng Jiang; Robert J Konrad; Ming-Shang Kuo; Yue-Wei Qian; He Wang; Lan Yu; David A Yurek; Guoqing Cao; Jian Wang
Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometry.
Analytical biochemistry 2013;438(1):61-6.
2012: Jason S Troutt; Bo Angelin; Anthony M Butterfield; Guoqing Cao; Lena Persson; Mats Rudling; Andrew E Schade; Lars Ståhle; Robert J Konrad
Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administration.
Clinical chemistry 2012;58(8):1225-32.
2012: Zhiqiang Li; Jing Liu; Tae-Sik Park; Ming-Shang Kuo; Yan Li; Hai H Bui; Guoqing Cao; Yifan Fan; Chongmin Huan; Xian-Cheng Jiang
Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(7):1577-84.
2012: Ana Escribano; Timothy M Jones; Thomas P Beyer; Anthony G Borel; Ellen A Cannady; Guoqing Cao; Sandra L Cockerham; Eva M Martin de la Nava; Ana I Mateo; Daniel R Mayhugh; Robert J Schmidt; Stephanie A Sweetana; Youyan Zhang; Nathan Mantlo
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(11):3671-5.
2012: Maria-Carmen Fernandez; Scott Frank; Timothy M Jones; Thomas P Beyer; Anthony Borel; Ellen A Cannady; Guoqing Cao; Sandra L Cockerham; Ana Escribano; Eva M Martin de la Nava; Ana I Mateo; Saravanan Parthasarathy; Robert J Schmidt; Gregory Stephenson; Stephanie A Sweetana; Xiaodong Wang; Youyan Zhang; Nathan Mantlo
Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(9):3056-62.
2011: Guoqing Cao; Yan Q Chen; Sandra L Cockerham; Todd Fields; Sotirios Karathanasis; Thomas P Beyer; Ellen A Cannady; Robert J Schmidt; Youyan Zhang; Karen M Zimmerman; Nathan Mantlo
Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure.
Journal of lipid research 2011;52(12):2169-76.
2011: Yanqun Chen; Yue-Wei Qian; He Wang; Lan Yu; Xiaohong Yu; Guoqing Cao; Jian Wang
Role of ubiquitination in PCSK9-mediated low-density lipoprotein receptor degradation.
Biochemical and biophysical research communications 2011;415(3):515-8.
2011: Zhiqiang Li; Chien-Ping Liang; Jing Liu; Tae-Sik Park; David A Peake; Phillip E Sanders; Gladys Teitelman; Hongqi Zhang; Youyan Zhang; Thomas Beyer; Hai H Bui; Guoqing Cao; Ming-Shang Kuo; Yan Li; Yue Li; Xian-Cheng Jiang
Reducing plasma membrane sphingomyelin increases insulin sensitivity.
Molecular and cellular biology 2011;31(20):4205-18.
2011: Jason S Troutt; Robert W Siegel; Jinbiao Chen; John H Sloan; Mark A Deeg; Guoqing Cao; Robert J Konrad
Dual-monoclonal, sandwich immunoassay specific for glucose-dependent insulinotropic peptide1-42, the active form of the incretin hormone.
Clinical chemistry 2011;57(6):849-55.
2011: Yong Gang Yue; Yan Qun Chen; Youyan Zhang; He Wang; Yue-Wei Qian; Jeffrey S Arnold; John N Calley; Shuyu D Li; William L Perry; Hong Y Zhang; Robert J Konrad; Guoqing Cao
The acyl coenzymeA:monoacylglycerol acyltransferase 3 (MGAT3) gene is a pseudogene in mice but encodes a functional enzyme in rats.
Lipids 2011;46(6):513-20.
2011: Robert J Konrad; Jason S Troutt; Guoqing Cao
Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents.
Lipids in health and disease 2011;10():38.
2010: Yifan Fan; Fujun Shi; Jing Liu; Jibin Dong; Hai H Bui; David A Peake; Ming-Shang Kuo; Guoqing Cao; Xian-Cheng Jiang
Selective reduction in the sphingomyelin content of atherogenic lipoproteins inhibits their retention in murine aortas and the subsequent development of atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(11):2114-20.
2010: Jason S Troutt; William E Alborn; Melissa A Bellinger; Karen L Cox; Mariam E Ehsani; Xiliang Wang; Yue-Wei Qian; John H Sloan; Mark B Willey; Guoqing Cao; Robert J Konrad
Development of a novel sandwich ELISA for measuring cell lysate ABCA1 protein levels.
Lipids 2010;45(8):757-64.
2010: Jason S Troutt; William E Alborn; Guoqing Cao; Robert J Konrad
Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levels.
Journal of lipid research 2010;51(2):345-51.
2009: Jing Liu; Chongmin Huan; Mahua Chakraborty; Hongqi Zhang; Da Lu; Ming-Shang Kuo; Guoqing Cao; Xian-Cheng Jiang
Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice.
Circulation research 2009;105(3):295-303.
2009: Jing Liu; Hongqi Zhang; Zhiqiang Li; Tiruneh K Hailemariam; Mahua Chakraborty; Kailiu Jiang; Daniel Qiu; Hai H Bui; David A Peake; Ming-Shang Kuo; Raj Wadgaonkar; Guoqing Cao; Xian-Cheng Jiang
Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):850-6.
2009: Yang Zhao; Yan-Qun Chen; Shuyu Li; Robert J Konrad; Guoqing Cao
The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.
Journal of lipid research 2009;50(5):945-56.
2008: Thomas P Beyer; Yanqun Chen; Regina K Porter; Deshun Lu; Robert J Schmidt; Nathan Mantlo; Robert J Konrad; Guoqing Cao
Peroxisome proliferator-activated receptor alpha agonists regulate cholesterol ester transfer protein.
Lipids 2008;43(7):611-8.
2008: Robert J Schmidt; Thomas P Beyer; William R Bensch; Yue-Wei Qian; Aiming Lin; Mark Kowala; William E Alborn; Robert J Konrad; Guoqing Cao
Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo.
Biochemical and biophysical research communications 2008;370(4):634-40.
2008: Yan Qun Chen; Ming-Shang Kuo; Shuyu Li; Hai H Bui; David A Peake; Philip E Sanders; Stefan J Thibodeaux; Shaoyou Chu; Yue-Wei Qian; Yang Zhao; David S Bredt; David E Moller; Robert J Konrad; Anne P Beigneux; Stephen G Young; Guoqing Cao
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.
The Journal of biological chemistry 2008;283(15):10048-57.
2008: Robert J Schmidt; Youyan Zhang; Yang Zhao; Yue-Wei Qian; He Wang; Aimin Lin; Mariam E Ehsani; Xiaohong Yu; Guoming Wang; Jaipal Singh; Eric W Su; Shuyu Li; Robert J Konrad; Guoqing Cao
A novel splicing variant of proprotein convertase subtilisin/kexin type 9.
DNA and cell biology 2008;27(4):183-9.
2008: Yang Zhao; Yan-Qun Chen; Tabetha M Bonacci; David S Bredt; Shuyu Li; William R Bensch; David E Moller; Mark Kowala; Robert J Konrad; Guoqing Cao
Identification and characterization of a major liver lysophosphatidylcholine acyltransferase.
The Journal of biological chemistry 2008;283(13):8258-65.
2008: Jian Wang; Lan Yu; He Wang; Yunling Gao; James P Schrementi; Regina K Porter; David A Yurek; Mingshang Kuo; Chen-Shian Suen; Guoqing Cao; James S Bean; Raymond F Kauffman; Yuewei Qian
Identification and characterization of hamster stearoyl-CoA desaturase isoforms.
Lipids 2008;43(3):197-205.
2008: Jason S Troutt; William E Alborn; Marian K Mosior; Jiannong Dai; Anthony T Murphy; Thomas P Beyer; Youyan Zhang; Guoqing Cao; Robert J Konrad
An apolipoprotein A-I mimetic dose-dependently increases the formation of prebeta1 HDL in human plasma.
Journal of lipid research 2008;49(3):581-7.
2008: Holly E Careskey; R Aleks Davis; William E Alborn; Jason S Troutt; Guoqing Cao; Robert J Konrad
Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9.
Journal of lipid research 2008;49(2):394-8.
2007: William E Alborn; Guoqing Cao; Holly E Careskey; Yue-Wei Qian; Danise R Subramaniam; Julian Davies; Elaine M Conner; Robert J Konrad
Serum proprotein convertase subtilisin kexin type 9 is correlated directly with serum LDL cholesterol.
Clinical chemistry 2007;53(10):1814-9.
2007: Zhiqiang Li; Tiruneh K Hailemariam; Hongwen Zhou; Yan Li; Dale C Duckworth; David A Peake; Youyan Zhang; Ming-Shang Kuo; Guoqing Cao; Xian-Cheng Jiang
Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.
Biochimica et biophysica acta 2007;1771(9):1186-94.
2007: Yue-Wei Qian; Robert J Schmidt; Youyan Zhang; Shaoyou Chu; Aimin Lin; He Wang; Xiliang Wang; Thomas P Beyer; William R Bensch; Weiming Li; maryam ehsani; Deshun Lu; Robert J Konrad; Patrick I Eacho; David E Moller; Sotirios Karathanasis; Guoqing Cao
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis.
Journal of lipid research 2007;48(7):1488-98.
2007: Guoqing Cao; Kelly R Bales; Ronald B DeMattos; Steven M Paul
Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics.
Current Alzheimer research 2007;4(2):179-84.
2006: Hongwen Zhou; Zhiqiang Li; Mohammad Reza Hojjati; David Jang; Thomas P Beyer; Guoqing Cao; Alan R Tall; Xian-Cheng Jiang
Adipose tissue-specific CETP expression in mice: impact on plasma lipoprotein metabolism.
Journal of lipid research 2006;47(9):2011-9.
2006: Robert J Schmidt; James V Ficorilli; Youyan Zhang; Kelli S Bramlett; Thomas P Beyer; Kristen Borchert; Michele S Dowless; Keith A Houck; Burris thomas; Patrick I Eacho; Guosheng Liang; Li-Wei Guo; William K Wilson; Laura F Michael; Guoqing Cao
A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity.
Journal of lipid research 2006;47(5):1037-44.
2005: Tonghuan Hu; Patricia Foxworthy; Angela Siesky; James V Ficorilli; Hong Gao; Shuyu Li; Michael Christe; Timothy Ryan; Guoqing Cao; Patrick I Eacho; M Dodson Michael; Laura F Michael
Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha.
Endocrinology 2005;146(12):5380-7.
2005: Youyan Zhang; Robert J Schmidt; Patricia Foxworthy; Renee Emkey; Jennifer K Oler; Thomas H Large; He Wang; Eric W Su; Marion K Mosior; Patrick I Eacho; Guoqing Cao
Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A.
Biochemical and biophysical research communications 2005;334(2):729-32.
2004: Yu Liang; Xian-Cheng Jiang; Ruijie Liu; Guosheng Liang; Thomas P Beyer; Hong Gao; Timothy P Ryan; Shuyu Dan Li; Patrick I Eacho; Guoqing Cao
Liver X receptors (LXRs) regulate apolipoprotein AIV-implications of the antiatherosclerotic effect of LXR agonists.
Molecular endocrinology (Baltimore, Md.) 2004;18(8):2000-10.
2004: Thomas P Beyer; Robert J Schmidt; Patricia Foxworthy; Youyan Zhang; Jiannong Dai; William R Bensch; Raymond F Kauffman; Hong Gao; Timothy P Ryan; Xian-Cheng Jiang; Sotirios Karathanasis; Patrick I Eacho; Guoqing Cao
Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo.
The Journal of pharmacology and experimental therapeutics 2004;309(3):861-8.
2004: Yu Liang; Suizhen Lin; Thomas P Beyer; Youyan Zhang; Xin Wu; Kelly R Bales; Ronald B DeMattos; Patrick May; Shuyu Dan Li; Xian-Cheng Jiang; Patrick I Eacho; Guoqing Cao; Steven M Paul
A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.
Journal of neurochemistry 2004;88(3):623-34.
2003: Xian-Cheng Jiang; Thomas P Beyer; Zhiqiang Li; Jin Liu; Wei Quan; Robert J Schmidt; Youyan Zhang; William R Bensch; Patrick I Eacho; Guoqing Cao
Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression.
The Journal of biological chemistry 2003;278(49):49072-8.
2003: Kelli S Bramlett; Keith A Houck; Kristen M Borchert; Michele S Dowless; Palaniappan Kulanthaivel; Youyan Zhang; Thomas P Beyer; Robert Schmidt; Jeffrey S Thomas; Laura F Michael; Robert Barr; Chahrzad Montrose; Patrick I Eacho; Guoqing Cao; Burris thomas
A natural product ligand of the oxysterol receptor, liver X receptor.
The Journal of pharmacology and experimental therapeutics 2003;307(1):291-6.
2003: Jeffrey Thomas; Kelli S Bramlett; Chahrzad Montrose; Patricia Foxworthy; Patrick I Eacho; Denis McCann; Guoqing Cao; Anton Kiefer; Jeff McCowan; Kuo-Long Yu; Timothy Grese; William W Chin; Burris thomas; Laura F Michael
A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.
The Journal of biological chemistry 2003;278(4):2403-10.
2003: Guoqing Cao; Yu Liang; Carol L Broderick; Brian A Oldham; Thomas P Beyer; Robert J Schmidt; Youyan Zhang; Keith R Stayrook; Chen S Suen; Keith A Otto; Anne R Miller; Jiannong Dai; Patricia Foxworthy; Hong Gao; Timothy P Ryan; Xian-Cheng Jiang; Burris thomas; Patrick I Eacho; Garret J Etgen
Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.
The Journal of biological chemistry 2003;278(2):1131-6.
2002: Guoqing Cao; Thomas P Beyer; Xiao Ping Yang; Robert J Schmidt; Youyan Zhang; William R Bensch; Raymond F Kauffman; Hong Gao; Timothy P Ryan; Yu Liang; Patrick I Eacho; Xian-Cheng Jiang
Phospholipid transfer protein is regulated by liver X receptors in vivo.
The Journal of biological chemistry 2002;277(42):39561-5.
2002: Youyan Zhang; Thomas P Beyer; Kelli S Bramlett; Sufang Yao; Burris thomas; Robert J Schmidt; Patrick I Eacho; Guoqing Cao
Liver X receptor and retinoic X receptor mediated ABCA1 regulation and cholesterol efflux in macrophage cells-messenger RNA measured by branched DNA technology.
Molecular genetics and metabolism 2002;77(1-2):150-8.
2002: Burris thomas; Patrick I Eacho; Guoqing Cao
Genetic disorders associated with ATP binding cassette cholesterol transporters.
Molecular genetics and metabolism 2002;77(1-2):13-20.