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Sakae Tanaka

Research Profile

Anatomy

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Rheumatoid Arthritis

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Hiroshi Inui; Kensuke Nakamura; Takaki Sanada; Shuji Taketomi; Sakae Tanaka; Takumi Nakagawa
An additional reference axis improves femoral rotation alignment in image-free computer navigation assisted total knee arthroplasty.
Takumi Matsumoto; Yuichi Nagase; Kozo Nakamura; Jun Hirose; Yuho Kadono; Takashi Kadowaki; Naoto Tokuyama; Kohjiro Ueki; Tetsuro Yasui; Sakae Tanaka
Regulation of bone resorption and sealing zone formation in osteoclasts occurs through protein kinase b-mediated microtubule stabilization.
Kumiko Ono; Satoru Ohashi; Sakae Tanaka
[Rheumatoid arthritis and bone -periarticular and systemic bone loss-].

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2013: Hiroshi Inui; Kensuke Nakamura; Takaki Sanada; Shuji Taketomi; Sakae Tanaka; Takumi Nakagawa
An additional reference axis improves femoral rotation alignment in image-free computer navigation assisted total knee arthroplasty.
The Journal of arthroplasty 2013;28(5):766-71.
2013: Takumi Matsumoto; Yuichi Nagase; Kozo Nakamura; Jun Hirose; Yuho Kadono; Takashi Kadowaki; Naoto Tokuyama; Kohjiro Ueki; Tetsuro Yasui; Sakae Tanaka
Regulation of bone resorption and sealing zone formation in osteoclasts occurs through protein kinase b-mediated microtubule stabilization.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(5):1191-202.
2013: Kumiko Ono; Satoru Ohashi; Sakae Tanaka
[Rheumatoid arthritis and bone -periarticular and systemic bone loss-].
Clinical calcium 2013;23(2):249-55.
2013: Sakae Tanaka
Regulation of bone destruction in rheumatoid arthritis through RANKL-RANK pathways.
World journal of orthopedics 2013;4(1):1-6.
2013: Kosuke Uehara; Toshiki Miura; Hideaki Miyamoto; Yutaka Morizaki; Takashi Ohe; Sakae Tanaka
Ultrasonographic evaluation of displaced neurovascular bundle in Dupuytren disease.
The Journal of hand surgery 2013;38(1):23-8.
2013: Shigeyuki Muraki; Keiji Nagata; Kozo Nakamura; Hiroyuki Oka; Sakae Tanaka; Munehito Yoshida; Toru Akune; Yuyu Ishimoto; Hiroshi Kawaguchi; Noriko Yoshimura
Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women: the ROAD Study.
Bone 2013;52(1):516-23.
2013: Yasuyuki Jujo; Yuho Kadono; Yuichi Nagase; Hiroyuki Oka; Tetsuro Yasui; Sakae Tanaka
Patellar fracture after total knee arthroplasty for rheumatoid arthritis.
The Journal of arthroplasty 2013;28(1):40-3.
2013: Teruhisa Kanazawa; Jinju Nishino; Shigeto Tohma; Sakae Tanaka
Analysis of the affected joints in rheumatoid arthritis patients in a large Japanese cohort.
Modern rheumatology / the Japan Rheumatism Association 2013;23(1):44-9.
2012: Masahiro Shinohara; Sakae Tanaka; Kohjiro Ueki; Jun Hirose; Mitsuyasu Iwasawa; Yuho Kadono; Takashi Kadowaki; Shigeaki Kato; Hironari Masuda; Yuuichi Nagase; Hiroaki Nakamura; Masaki Nakamura; Takehiko Sasaki; Hiroshi Takayanagi
Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(12):2464-75.
2012: Hideaki Miyamoto; Euan Morita; Yutaka Morizaki; Takashi Ohe; Toshiki Miura; Kosuke Uehara; Sakae Tanaka
Fungal arthritis of the wrist caused by Candida parapsilosis during infliximab therapy for rheumatoid arthritis.
Modern rheumatology / the Japan Rheumatism Association 2012;22(6):903-6.
2012: Yasushi Oshima; Atsushi Seichi; Katsushi Takeshita; Satoshi Baba; Hirotaka Chikuda; Hiroshi Kawaguchi; Jiro Morii; Kozo Nakamura; Hiroyuki Oka; Takashi Ono; Sakae Tanaka
Natural course and prognostic factors in patients with mild cervical spondylotic myelopathy with increased signal intensity on T2-weighted magnetic resonance imaging.
Spine 2012;37(22):1909-13.
2012: Satoru Ohashi; Sakae Tanaka
[Etiology of osteoporosis -decrease of bone mineral density and deterioration of bone quality-].
Clinical calcium 2012;22(6):805-11.
2012: Yasunori Omata; Sakae Tanaka
[Epigenetic regulation of osteoclastogenesis by histone modification].
Clinical calcium 2012;22(5):619-28.
2012: Noriko Yoshimura; Hiroshi Kawaguchi; Shigeyuki Muraki; Kozo Nakamura; Hiroyuki Oka; Sakae Tanaka; Toru Akune
Does mild cognitive impairment affect the occurrence of radiographic knee osteoarthritis? A 3-year follow-up in the ROAD study.
BMJ open 2012;2(6):.
2012: Ayako Mochizuki; Tsuyoshi Nakamaki; Masamichi Takami; Sakae Tanaka; Shigeru Tomoyasu; Tomio Inoue; Yuho Kadono; Yoichi Miyamoto; Ryutaro Kamijo
Cell adhesion signaling regulates RANK expression in osteoclast precursors.
PloS one 2012;7(11):e48795.
2012: Naoko Shoda; Hideo Yasunaga; Hiromasa Horiguchi; Yuho Kadono; Shinya Matsuda; Kazuhiko Ohe; Sakae Tanaka
Risk factors affecting inhospital mortality after hip fracture: retrospective analysis using the Japanese Diagnosis Procedure Combination Database.
BMJ open 2012;2(3):.
2011: Yuichi Nagase; Kozo Nakamura; Naoko Shoda; Hideki Hashimoto; Hiromasa Horiguchi; Yuho Kadono; Shinya Matsuda; Hideo Yasunaga; Sakae Tanaka
Risk factors for pulmonary embolism and the effects of fondaparinux after total hip and knee arthroplasty: a retrospective observational study with use of a national database in Japan.
The Journal of bone and joint surgery. American volume 2011;93(24):e146.
2011: Koji Yamada; Fumiaki Tokimura; Kunihiro Matsumoto; Hiroshi Okazaki; Sakae Tanaka
Are bone and serum cefazolin concentrations adequate for antimicrobial prophylaxis?
Clinical orthopaedics and related research 2011;469(12):3486-94.
2011: Takumi Matsumoto; Yuichi Nagase; Kozo Nakamura; Mitsuyasu Iwasawa; Yuho Kadono; Hironari Masuda; Tetsuro Yasui; Sakae Tanaka
Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: role of the Akt pathway and the ERK/Bim axis.
Arthritis and rheumatism 2011;63(12):3908-17.
2011: Tetsuro Yasui; Shuichi Tsutsumi; Hiroyuki Aburatani; Jun Hirose; Kozo Nakamura; Sakae Tanaka
Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(11):2665-71.
2011: Yasunori Omata; Sakae Tanaka
[RANKL/RANK signaling in rheumatoid arthritis].
Clinical calcium 2011;21(8):1175-80.
2011: Tetsuro Yasui; Hisataka Yasuda; Jun Hirose; Takeshi Imamura; Yuho Kadono; Hironari Masuda; Takumi Matsumoto; Kozo Nakamura; Masaki Nakamura; Yasunori Omata; Yasushi Oshima; Sakae Tanaka
Regulation of RANKL-induced osteoclastogenesis by TGF-β through molecular interaction between Smad3 and Traf6.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(7):1447-56.
2011: T Ueno; Y Ohori; J Ito; S Hoshikawa; Shigeru Yamamoto; Kozo Nakamura; Sakae Tanaka; Masami Akai; Y Tobimatsu; T Ogata
Hyperphosphorylated neurofilament NF-H as a biomarker of the efficacy of minocycline therapy for spinal cord injury.
Spinal cord 2011;49(3):333-6.
2011: Yuichi Nagase; Sakae Tanaka
[Odanacatib (MK-0822)].
Clinical calcium 2011;21(1):59-62.
2010: Toru Doi; Tsuyoshi Miyazaki; Jinju Nishino; Sakae Tanaka; Toshihiro Matsui; Akiko Komiya; Seizo Yamamoto; Fumiaki Tokimura; Toshihito Mori; Keita Nishimura; Narutaka Katoh; Jun Hasegawa; Yasunori Omata; Takashi Matsushita; Shigeto Tohma
Neutrophil CD64 expression as a diagnostic marker for local infection and crystal-induced arthritis.
Modern rheumatology / the Japan Rheumatism Association 2010;20(6):573-9.
2010: Naoto Tokuyama; Sakae Tanaka
[Cytokines in bone diseases. Genetic disorders of RANKL-RANK-OPG system].
Clinical calcium 2010;20(10):1532-8.
2010: Jinju Nishino; Sakae Tanaka; Yuho Kadono; Toshihiro Matsui; Akiko Komiya; Keita Nishimura; Shigeto Tohma
The usefulness of neutrophil CD64 expression in the diagnosis of local infection in patients with rheumatoid arthritis in daily practice.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2010;15(4):547-52.
2010: Shigeki Arii; Sakae Tanaka; Y Mitsunori; Noriaki Nakamura; A Kudo; Norio Noguchi; T Irie
Surgical strategies for hepatocellular carcinoma with special reference to anatomical hepatic resection and intraoperative contrast-enhanced ultrasonography.
Oncology 2010;78 Suppl 1():125-30.
2010: Tetsuro Yasui; Jinju Nishino; Yuho Kadono; T Matsui; Kozo Nakamura; Sakae Tanaka; Shigeto Tohma
Impact of biologics on the prevalence of orthopedic surgery in the National Database of Rheumatic Diseases in Japan.
Modern rheumatology / the Japan Rheumatism Association 2010;20(3):233-7.
2010: Yuichi Nagase; Mitsuyasu Iwasawa; Toru Akiyama; Naoshi Ogata; Yuho Kadono; Masaki Nakamura; Yasushi Oshima; Tetsuro Yasui; Takumi Matsumoto; Hironari Masuda; Philippe Bouillet; Kozo Nakamura; Sakae Tanaka
Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of parathyroid hormone in bone.
Annals of the New York Academy of Sciences 2010;1192():330-7.
2010: Yuho Kadono; Hideo Yasunaga; Hiromasa Horiguchi; Hideki Hashimoto; Shinya Matsuda; Sakae Tanaka; Kozo Nakamura
Statistics for orthopedic surgery 2006-2007: data from the Japanese Diagnosis Procedure Combination database.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2010;15(2):162-70.
2010: Sakae Tanaka; Hidetoshi Wakeyama; Toru Akiyama; Katsuhiko Takahashi; Hitoshi Amano; Keiichi I Nakayama; Kozo Nakamura
Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3.
Advances in experimental medicine and biology 2010;658():111-6.
2009: Yuichi Nagase; Mitsuyasu Iwasawa; Toru Akiyama; Yuho Kadono; Masaki Nakamura; Yasushi Oshima; Tetsuro Yasui; Takumi Matsumoto; Jun Hirose; Hiroaki Nakamura; Takeshi Miyamoto; Philippe Bouillet; Kozo Nakamura; Sakae Tanaka
Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts.
The Journal of biological chemistry 2009;284(52):36659-69.
2009: Sakae Tanaka; Hiroyasu Nakano
NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis.
The Journal of clinical investigation 2009;119(10):2879-81.
2009: Mitsuyasu Iwasawa; Tsuyoshi Miyazaki; Yuichi Nagase; Toru Akiyama; Yuho Kadono; Masaki Nakamura; Yasushi Oshima; Tetsuro Yasui; Takumi Matsumoto; Takashi Nakamura; Shigeaki Kato; Lothar Hennighausen; Kozo Nakamura; Sakae Tanaka
The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice.
The Journal of clinical investigation 2009;119(10):3149-59.
2009: Sakae Tanaka; Jo Nishino; T Matsui; A Komiya; K Nishimura; Shigeto Tohma
Neutrophil CD64 expression in the diagnosis of local musculoskeletal infection and the impact of antibiotics.
The Journal of bone and joint surgery. British volume 2009;91(9):1237-42.
2009: Atsuhiko Hikita; Nobuho Tanaka; Shoji Yamane; Yasuko Ikeda; Hiroshi Furukawa; Shigeto Tohma; Ryuji Suzuki; Sakae Tanaka; Hiroyuki Mitomi; Naoshi Fukui
Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2009;87(4):581-93.
2009: Hironari Masuda; Sakae Tanaka
[Drugs under development for osteoporosis ].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(5):980-4.
2009: Yuho Kadono; Sakae Tanaka
[Prevention of joint destruction by osteoclast-targeting therapy in search of new tools, such as OPG or cathepsin K inhibitor].
Clinical calcium 2009;19(3):387-93.
2009: Yuho Kadono; Sakae Tanaka; Jinju Nishino; Keita Nishimura; Ichiro Nakamura; Tsuyoshi Miyazaki; Hiroshi Takayanagi; Kozo Nakamura
Rheumatoid arthritis associated with osteopetrosis.
Modern rheumatology / the Japan Rheumatism Association 2009;19(6):687-90.
2009: Jinju Nishino; Sakae Tanaka; Toshihiro Matsui; Toshihito Mori; Keita Nishimura; Yoshito Eto; Atsushi Kaneko; Koichiro Saisho; Masayuki Yasuda; Noriyuki Chiba; Yasuhiko Yoshinaga; Yukihiko Saeki; Atsuhito Seki; Shigeto Tohma
Prevalence of joint replacement surgery in rheumatoid arthritis patients: cross-sectional analysis in a large observational cohort in Japan.
Modern rheumatology / the Japan Rheumatism Association 2009;19(3):260-4.
2008: Yasushi Oshima; Toru Akiyama; Atsuhiko Hikita; Mitsuyasu Iwasawa; Yuichi Nagase; Masaki Nakamura; Hidetoshi Wakeyama; Naohiro Kawamura; Toshiyuki Ikeda; Ung-il Chung; Lothar Hennighausen; Hiroshi Kawaguchi; Kozo Nakamura; Sakae Tanaka
Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.
The Journal of biological chemistry 2008;283(39):26499-508.
2008: Eun-Ju Chang; Jeongim Ha; Frank Oerlemans; You Jin Lee; Soo Woong Lee; Jiyoon Ryu; Hyung Joon Kim; Youngkyun Lee; Hyun-Man Kim; Je-Yong Choi; Jin Young Kim; Chan Soo Shin; Youngmi Kim Pak; Sakae Tanaka; Bé Wieringa; Zang Hee Lee; Hong-Hee Kim
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption.
Nature medicine 2008;14(9):966-72.
2008: Rieko Ajima; Toru Akiyama; Michihiko Usui; Mitsuhiro Yoneda; Yutaka Yoshida; Takahisa Nakamura; Osamu Minowa; Masaki Noda; Sakae Tanaka; Tetsuo Noda; Tadashi Yamamoto
Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation.
FEBS letters 2008;582(9):1313-8.
2008: Chiaki Okuma; Takefumi Kaketa; Atsuhiko Hikita; Koichi Matsuda; Masaki Nakamura; Yuichi Nagase; Yasushi Oshima; Mitsuyasu Iwasawa; Yusuke Nakamura; Hisashi Kurosawa; Kozo Nakamura; Sakae Tanaka
Potential involvement of p53 in ischemia/reperfusion-induced osteonecrosis.
Journal of bone and mineral metabolism 2008;26(6):576-85.
2008: Shinya Hoshikawa; Toru Ogata; Sayaka Fujiwara; Kozo Nakamura; Sakae Tanaka
A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.
PloS one 2008;3(10):e3464.
2008: Chiaki Okuma-Yoshioka; Hiroaki Seto; Yuho Kadono; Atsuhiko Hikita; Yasushi Oshima; Hisashi Kurosawa; Kozo Nakamura; Sakae Tanaka
Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways.
Modern rheumatology / the Japan Rheumatism Association 2008;18(4):366-78.
2007: Hidetoshi Wakeyama; Toru Akiyama; Yuho Kadono; Masaki Nakamura; Yasushi Oshima; Kozo Nakamura; Sakae Tanaka
Posttranslational regulation of Bim by caspase-3.
Annals of the New York Academy of Sciences 2007;1116():271-80.
2007: Hidetoshi Wakeyama; Toru Akiyama; Katsuhiko Takahashi; Hitoshi Amano; Yuho Kadono; Masaki Nakamura; Yasushi Oshima; Hiroyuki Itabe; Keiichi I Nakayama; Keiko Nakayama; Kozo Nakamura; Sakae Tanaka
Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(10):1631-9.
2007: Sakae Tanaka
[RANKL as a target molecule for treatment of joint destruction].
Clinical calcium 2007;17(4):586-92.
2007: Naohiro Kawamura; Fumitaka Kugimiya; Yasushi Oshima; Shinsuke Ohba; Toshiyuki Ikeda; Taku Saito; Yusuke Shinoda; Yosuke Kawasaki; Naoshi Ogata; Kazuto Hoshi; Toru Akiyama; William S Chen; Nissim Hay; Kazuyuki Tobe; Takashi Kadowaki; Yoshiaki Azuma; Sakae Tanaka; Kozo Nakamura; Ung-il Chung; Hiroshi Kawaguchi
Akt1 in osteoblasts and osteoclasts controls bone remodeling.
PloS one 2007;2(10):e1058.
2007: Sakae Tanaka
Signaling axis in osteoclast biology and therapeutic targeting in the RANKL/RANK/OPG system.
American journal of nephrology 2007;27(5):466-78.
2007: Ayako Suematsu; Yasuhito Tajiri; Tomoki Nakashima; Junko Taka; Sae Ochi; Hiromi Oda; Kozo Nakamura; Sakae Tanaka; Hiroshi Takayanagi
Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis.
Modern rheumatology / the Japan Rheumatism Association 2007;17(1):17-23.
2007: Shin-jiro Kono; Yasushi Oshima; Kazuto Hoshi; Lynda F Bonewald; Hiromi Oda; Kozo Nakamura; Hiroshi Kawaguchi; Sakae Tanaka
Erk pathways negatively regulate matrix mineralization.
Bone 2007;40(1):68-74.
2006: Yasuhiro Sawada; Masako Tamada; Benjamin J Dubin-Thaler; Oksana Cherniavskaya; Ryuichi Sakai; Sakae Tanaka; Michael P Sheetz
Force sensing by mechanical extension of the Src family kinase substrate p130Cas.
Cell 2006;127(5):1015-26.
2006: Atsuhiko Hikita; Ikuo Yana; Hidetoshi Wakeyama; Masaki Nakamura; Yuho Kadono; Yasushi Oshima; Kozo Nakamura; Motoharu Seiki; Sakae Tanaka
Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand.
The Journal of biological chemistry 2006;281(48):36846-55.
2006: kojiro sato; Ayako Suematsu; Kazuo Okamoto; Akira Yamaguchi; Yasuyuki Morishita; Yuho Kadono; Sakae Tanaka; Tatsuhiko Kodama; Shizuo Akira; Yoichiro Iwakura; Daniel J Cua; Hiroshi Takayanagi
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.
The Journal of experimental medicine 2006;203(12):2673-82.
2006: Naoshi Fukui; Yasuko Ikeda; Toshiyuki Ohnuki; Atsuhiko Hikita; Sakae Tanaka; Shoji Yamane; Ryuji Suzuki; Linda J Sandell; Takahiro Ochi
Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation.
The Journal of biological chemistry 2006;281(37):27229-41.
2006: Sakae Tanaka
[Bone disease related to rheumatoid arthritis].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(9):1712-7.
2006: Tetsuro Yasui; Sakae Tanaka
[Current topics in drug therapy aiming at bone resorption].
Clinical calcium 2006;16(9):1475-79.
2006: Yuichi Nagase; Sakae Tanaka
[Osteopetrosis].
Nihon rinsho. Japanese journal of clinical medicine 2006;Suppl 2():152-5.
2006: Sakae Tanaka; Tsuyoshi Miyazaki; Akira Fukuda; Toru Akiyama; Yuho Kadono; Hidetoshi Wakeyama; Shinjiro Kono; Shinya Hoshikawa; Masaki Nakamura; Yasushi Ohshima; Atsuhiko Hikita; Ichiro Nakamura; Kozo Nakamura
Molecular mechanism of the life and death of the osteoclast.
Annals of the New York Academy of Sciences 2006;1068():180-6.
2006: Kenji Minemura; Miyuki Nagahara; Toshikatsu Kaburaki; Masahiko Sakurai; Makoto Araie; Sakae Tanaka; Takako Doi; Shu Okugawa; Kunihisa Tsukada
[Case of recurrent fungal endophthalmitis with suspected Munchausen syndrome].
Nippon Ganka Gakkai zasshi 2006;110(3):188-92.
2006: Toru Ogata; Shin-ichi Yamamoto; Kozo Nakamura; Sakae Tanaka
Signaling axis in schwann cell proliferation and differentiation.
Molecular neurobiology 2006;33(1):51-62.
2006: Sakae Tanaka; H Suzuki; H Yamauchi; I Nakamura; K Nakamura
Signal transduction pathways of calcitonin/calcitonin receptor regulating cytoskeletal organization and bone-resorbing activity of osteoclasts.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(3):19-23.
2006: Tsuyoshi Miyazaki; Sakae Tanaka; Archana Sanjay; Roland Baron
The role of c-Src kinase in the regulation of osteoclast function.
Modern rheumatology / the Japan Rheumatism Association 2006;16(2):68-74.
2005: Atsuhiko Hikita; Yuho Kadono; Hirotaka Chikuda; Akira Fukuda; Hidetoshi Wakeyama; Hisataka Yasuda; Kozo Nakamura; Hiromi Oda; Tsuyoshi Miyazaki; Sakae Tanaka
Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.
The Journal of biological chemistry 2005;280(50):41700-6.
2005: Sakae Tanaka; Kozo Nakamura; Naoyuki Takahasi; Tatsuo Suda
Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system.
Immunological reviews 2005;208():30-49.
2005: Akira Fukuda; Atsuhiko Hikita; Hidetoshi Wakeyama; Toru Akiyama; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(12):2245-53.
2005: Masaki Nakamura; Sakae Tanaka
[Mechanism of the bone destruction in rheumatoid arthritis].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(9):1571-3.
2005: Sakae Tanaka
[A novel therapeutic vaccine approach against RANKL that prevents pathological bone destruction].
Clinical calcium 2005;15(7):62-6.
2005: Sakae Tanaka
[Disorder of bone quality in osteopetrosis].
Clinical calcium 2005;15(6):993-9.
2005: Han Bok Kwak; Soo Woong Lee; Hye Mi Jin; Hyunil Ha; Sang Ho Lee; Sunao Takeshita; Sakae Tanaka; Hyun-Man Kim; Hong-Hee Kim; Zang Hee Lee
Monokine induced by interferon-gamma is induced by receptor activator of nuclear factor kappa B ligand and is involved in osteoclast adhesion and migration.
Blood 2005;105(7):2963-9.
2005: Jin Gohda; Toru Akiyama; Takako Koga; Hiroshi Takayanagi; Sakae Tanaka; Jun-Ichiro Inoue
RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis.
The EMBO journal 2005;24(4):790-9.
2005: Sakae Tanaka
Intracellular signal transduction pathways: good therapeutic targets for joint destruction in rheumatoid arthritis.
Modern rheumatology / the Japan Rheumatism Association 2005;15(1):19-27.
2005: Toru Akiyama; Tsuyoshi Miyazaki; Phillippe Bouillet; Kozo Nakamura; Andreas Strasser; Sakae Tanaka
In vitro and in vivo assays for osteoclast apoptosis.
Biological procedures online 2005;7():48-59.
2005: Atsuhiko Hikita; Sakae Tanaka
[Involvement of osteoclasts in cartilage and bone destruction in rheumatoid arthritis].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 1():84-6.
2004: Toru Ogata; Satoru Iijima; Shinya Hoshikawa; Toshiki Miura; Shin-ichi Yamamoto; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(30):6724-32.
2004: Hiroaki Seto; Sakae Tanaka; Hiroaki Seto; Hisashi Kurosawa
[Relationship between gene transfer and cartilage tissue engineering].
Clinical calcium 2004;14(7):72-5.
2004: Toru Ogasawara; Mika Katagiri; Aiichiro Yamamoto; Kazuto Hoshi; Tsuyoshi Takato; Kozo Nakamura; Sakae Tanaka; Hiroto Okayama; Hiroshi Kawaguchi
Osteoclast differentiation by RANKL requires NF-kappaB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(7):1128-36.
2004: Kiyoshi Setoguchi; Yoshikata Misaki; Kimito Kawahata; Kota Shimada; Takeo Juji; Sakae Tanaka; Hiromi Oda; Chisa Shukunami; Yuriko Nishizaki; Yuji Hiraki; Kazuhiko Yamamoto
Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis.
Arthritis and rheumatism 2004;50(3):828-39.
2004: Hiroaki Seto; Satoru Kamekura; Toshiki Miura; Aiichiro Yamamoto; Hirotaka Chikuda; Toru Ogata; Hisatada Hiraoka; Hiromi Oda; Kozo Nakamura; Hisashi Kurosawa; Ung-Il Chug; Hiroshi Kawaguchi; Sakae Tanaka
Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts.
The Journal of clinical investigation 2004;113(5):718-26.
2004: Tsuyoshi Miyazaki; Sakae Tanaka
[TNF-alpha].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 2():112-5.
2003: Toru Akiyama; Phillippe Bouillet; Tsuyoshi Miyazaki; Yuho Kadono; Hirotaka Chikuda; Ung-il Chung; Akira Fukuda; Atsuhiko Hikita; Hiroaki Seto; Takashi Okada; Toshiya Inaba; Archana Sanjay; Roland Baron; Hiroshi Kawaguchi; Hiromi Oda; Kozo Nakamura; Andreas Strasser; Sakae Tanaka
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.
The EMBO journal 2003;22(24):6653-64.
2003: Hong-Hee Kim; Woon Jae Chung; Soo Woong Lee; Pah-Jin Chung; Jae Won You; Ho Jeong Kwon; Sakae Tanaka; Zang Hee Lee
Association of sustained ERK activity with integrin beta3 induction during receptor activator of nuclear factor kappaB ligand (RANKL)-directed osteoclast differentiation.
Experimental cell research 2003;289(2):368-77.
2003: Aiichiro Yamamoto; Akira Fukuda; Hiroaki Seto; Tsuyoshi Miyazaki; Yuho Kadono; Yasuhiro Sawada; Ichiro Nakamura; Hideki Katagiri; Tomoichiro Asano; Yoshiya Tanaka; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts.
Arthritis and rheumatism 2003;48(9):2682-92.
2003: Reimi Kawaida; Toshiaki Ohtsuka; Junichi Okutsu; Tohru Takahashi; Yuho Kadono; Hiromi Oda; Atsuhiko Hikita; Kozo Nakamura; Sakae Tanaka; Hidehiko Furukawa
Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL.
The Journal of experimental medicine 2003;197(8):1029-35.
2003: Naoyuki Takahashi; Nobuyuki Udagawa; Sakae Tanaka; Tatsuo Suda
Generating murine osteoclasts from bone marrow.
Methods in molecular medicine 2003;80():129-44.
2003: Sakae Tanaka; Ichiro Nakamura; Jun-Ichiro Inoue; Hiromi Oda; Kozo Nakamura
Signal transduction pathways regulating osteoclast differentiation and function.
Journal of bone and mineral metabolism 2003;21(3):123-33.
2002: Sakae Tanaka
[Therapeutic vaccination approach against pathological bone disease].
Clinical calcium 2002;12(7):932-4.
2002: Ichiro Nakamura; Yuho Kadono; Hiroshi Takayanagi; Eijiro Jimi; Tsuyoshi Miyazaki; Hiromi Oda; Kozo Nakamura; Sakae Tanaka; Gideon A Rodan; Le T Duong
IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5103-9.
2002: Aiichiro Yamamoto; Tsuyoshi Miyazaki; Yuho Kadono; Hiroshi Takayanagi; Toshiki Miura; Hiroshi Nishina; Toshiaki Katada; Kenji Wakabayashi; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(4):612-21.
2002: Toshihiro Mochizuki; Akio Asai; Nobuhito Saito; Sakae Tanaka; Hideki Katagiri; Tomoichiro Asano; Makoto Nakane; Akira Tamura; Yoshiyuki Kuchino; Chifumi Kitanaka; Takaaki Kirino
Akt protein kinase inhibits non-apoptotic programmed cell death induced by ceramide.
The Journal of biological chemistry 2002;277(4):2790-7.
2002: Takeo Juji; Marc Hertz; Kazuhiro Aoki; Daisuke Horie; Keiichi Ohya; Anand Gautam; Søren Mouritsen; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders.
Journal of bone and mineral metabolism 2002;20(5):266-8.
2001: Sakae Tanaka; M Oda; Yoko Y Toyoshima; Teruhiko Wakayama; M Tanaka; N Yoshida; Naka Hattori; Jun Ohgane; Ryuzo Yanagimachi; Kunio Shiota
Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer.
Biology of reproduction 2001;65(6):1813-21.
2001: Takeo Saneyoshi; K S Min; X Jing Ma; Y Nambo; T Hiyama; Sakae Tanaka; Kunio Shiota
Equine follicle-stimulating hormone: molecular cloning of beta subunit and biological role of the asparagine-linked oligosaccharide at asparagine(56) of alpha subunit.
Biology of reproduction 2001;65(6):1686-90.
2001: Takamasa Uekita; Sakae Tanaka; Hiroshi Sato; Motoharu Seiki; Hideaki Tojo; Chikashi Tachi
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) mRNA in trophoblast and endometrial epithelial cell populations of the synepitheliochorial placenta of goats (Capra hircus).
Archives of histology and cytology 2001;64(4):411-24.
2001: Mayumi Oda; Weiyong Sun; Naka Hattori; Sakae Tanaka; Kunio Shiota
PAL31 expression in rat trophoblast giant cells.
Biochemical and biophysical research communications 2001;287(3):721-6.
2001: J H Cho; Hiroshi Kimura; Takashi Minami; Jun Ohgane; Naka Hattori; Sakae Tanaka; Kunio Shiota
DNA methylation regulates placental lactogen I gene expression.
Endocrinology 2001;142(8):3389-96.
2001: J Yan; Sakae Tanaka; M Oda; T Makino; Jun Ohgane; Kunio Shiota
Retinoic acid promotes differentiation of trophoblast stem cells to a giant cell fate.
Developmental biology 2001;235(2):422-32.
2001: Jun Ohgane; Teruhiko Wakayama; Yasushi Kogo; Sho Senda; Naka Hattori; Sakae Tanaka; Ryuzo Yanagimachi; Kunio Shiota
DNA methylation variation in cloned mice.
Genesis (New York, N.Y. : 2000) 2001;30(2):45-50.
2001: Sakae Tanaka
[Osteoporosis in rheumatoid arthritis: role of osteoclast differentiation and cytokines].
Clinical calcium 2001;11(5):598-601.
2001: Weiyong Sun; Naka Hattori; Hideki Mutai; Yoko Y Toyoshima; Hiroshi Kimura; Sakae Tanaka; Kunio Shiota
PAL31, a nuclear protein required for progression to the S phase.
Biochemical and biophysical research communications 2001;280(4):1048-54.
2000: Yutaka Yoshida; Sakae Tanaka; Hisashi Umemori; Osamu Minowa; Michihiko Usui; Naoko Ikematsu; E Hosoda; Takeshi Imamura; Junko Kuno; T Yamashita; Kohei Miyazono; Masaki Noda; Tetsuo Noda; Tadashi Yamamoto
Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
Cell 2000;103(7):1085-97.
2000: H Takayanagi; T Juji; T Miyazaki; H Iizuka; Sakae Tanaka; H Oda; K Nakamura
[Amelioration of adjuvant arthritis by gene therapy suppressing Src activity].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2000;23(6):547-9.
2000: T Nakagawa; Sakae Tanaka; H Suzuki; H Takayanagi; T Miyazaki; K Nakamura; Takashi Tsuruo
Overexpression of the csk gene suppresses tumor metastasis in vivo.
International journal of cancer. Journal international du cancer 2000;88(3):384-91.
2000: Toshiki Miura; Sakae Tanaka; Atsushi Seichi; Makoto Arai; Takahiro Goto; Hideki Katagiri; Tomoichiro Asano; Hiromi Oda; Kozo Nakamura
Partial functional recovery of paraplegic rat by adenovirus-mediated gene delivery of constitutively active MEK1.
Experimental neurology 2000;166(1):115-26.
2000: Hideki Mutai; Yoko Y Toyoshima; Weiyong Sun; Naka Hattori; Sakae Tanaka; Kunio Shiota
PAL31, a novel nuclear protein, expressed in the developing brain.
Biochemical and biophysical research communications 2000;274(2):427-33.
2000: K Iwatsuki; M Shinozaki; W Sun; S Yagi; Sakae Tanaka; Kunio Shiota
A novel secretory protein produced by rat spongiotrophoblast.
Biology of reproduction 2000;62(5):1352-9.
2000: Hiroshi Takayanagi; H Iizuka; Takeo Juji; Takumi Nakagawa; Aiichiro Yamamoto; Tsuyoshi Miyazaki; Y Koshihara; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(2):259-69.
2000: Tsuyoshi Miyazaki; H Katagiri; Yumi Kanegae; Hiroshi Takayanagi; Y Sawada; Aiichiro Yamamoto; Matthew Pando; Tomoichiro Asano; Inder M Verma; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts.
The Journal of cell biology 2000;148(2):333-42.
2000: Tsuyoshi Miyazaki; Hiroshi Takayanagi; Masashi Isshiki; T Takahashi; M Okada; Y Fukui; Hiromi Oda; Kozo Nakamura; H Hirai; T Kurokawa; Sakae Tanaka
In vitro and in vivo suppression of osteoclast function by adenovirus vector-induced csk gene.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(1):41-51.
1999: Michiyo Higashi; Suguru Yonezawa; J J Ho; Sakae Tanaka; Tatsuro Irimura; Y S Kim; Eiichi Sato
Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: its relationship with a new morphological classification of cholangiocarcinoma.
Hepatology (Baltimore, Md.) 1999;30(6):1347-55.
1999: Hiroshi Takayanagi; Takeo Juji; Tsuyoshi Miyazaki; H Iizuka; T Takahashi; Masashi Isshiki; M Okada; Yoshiya Tanaka; Y Koshihara; Hiromi Oda; T Kurokawa; Kozo Nakamura; Sakae Tanaka
Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts.
The Journal of clinical investigation 1999;104(2):137-46.
1999: Asuka Naito; Sakura Azuma; Sakae Tanaka; Tsuyoshi Miyazaki; Satoshi Takaki; Kiyoshi Takatsu; K Nakao; Kozo Nakamura; Motoya Katsuki; Tadashi Yamamoto; Jun-Ichiro Inoue
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(6):353-62.
1999: T Ogata; Sakae Tanaka; Takahiro Goto; Takuo Iijima; Hirotaka Kawano; M Sasaki; T Ishida; Kozo Nakamura
Giant trichoblastoma mimicking malignancy.
Archives of orthopaedic and trauma surgery 1999;119(3-4):225-7.
1998: Hiroshi Kimura; T Takeda; Sakae Tanaka; T Ogawa; Kunio Shiota
Expression of rat DNA (cytosine-5) methyltransferase (DNA MTase) in rodent trophoblast giant cells: molecular cloning and characterization of rat DNA MTase.
Biochemical and biophysical research communications 1998;253(2):495-501.
1998: K Iwatsuki; M Oda; W Sun; Sakae Tanaka; T Ogawa; Kunio Shiota
Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein H.
Endocrinology 1998;139(12):4976-83.
1998: Sakae Tanaka; T Takahashi; Hiroshi Takayanagi; Tsuyoshi Miyazaki; Hiromi Oda; Kozo Nakamura; H Hirai; T Kurokawa
Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(11):1714-20.
1998: Naka Hattori; T Nukada; M Oda; Sakae Tanaka; Toshihisa Ogawa; Kunio Shiota
Evaluation of the role of N-linked oligosaccharides in rat placental lactogen action by site-directed mutagenesis.
Endocrine journal 1998;45(5):659-74.
1998: K A Kelly; Sakae Tanaka; R Baron; Jeffrey M Gimble
Murine bone marrow stromally derived BMS2 adipocytes support differentiation and function of osteoclast-like cells in vitro.
Endocrinology 1998;139(4):2092-101.
1997: Hiroshi Takayanagi; Hiromi Oda; Shigeru Yamamoto; Hiroshi Kawaguchi; Sakae Tanaka; Takako Nishikawa; Y Koshihara
A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis.
Biochemical and biophysical research communications 1997;240(2):279-86.
1997: Karl Insogna; M Sahni; Andrew Grey; Sakae Tanaka; William C Horne; Lynn Neff; Mary Ann Mitnick; Joan B Levy; Roland Baron
Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts.
The Journal of clinical investigation 1997;100(10):2476-85.
1997: I Nakamura; T Sasaki; Sakae Tanaka; Naoyuki Takahashi; E Jimi; T Kurokawa; Yoshihiro Kita; S Ihara; Toshio Suda; Y Fukui
Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts.
Journal of cellular physiology 1997;172(2):230-9.
1997: H Murakami; Naoyuki Takahashi; Sakae Tanaka; I Nakamura; Nobuyuki Udagawa; S Nakajo; K Nakaya; M Abe; Y Yuda; F Konno; A Barbier; Toshio Suda
Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts.
Bone 1997;20(5):399-404.
1997: Sakae Tanaka; Y Mariko; Hidetoshi Mori; J Ishijima; Susumu Tachi; Hiroshi Sato; Motoharu Seiki; Keitaro Yamanouchi; Hideaki Tojo; Chikashi Tachi
Cell-cell contact down-regulates expression of membrane type metalloproteinase-1 (MT1-MMP) in a mouse mammary gland epithelial cell line.
Zoological science 1997;14(1):95-9.
1997: Karl Insogna; Sakae Tanaka; Lynn Neff; William C Horne; J Levy; R Baron
Role of c-Src in cellular events associated with colony-stimulating factor-1-induced spreading in osteoclasts.
Molecular reproduction and development 1997;46(1):104-8.
1996: Sakae Tanaka; Michael Amling; Lynn Neff; Anusch Peyman; E Uhlmann; J B Levy; Roland Baron
c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.
Nature 1996;383(6600):528-31.
1995: H Murakami; Naoyuki Takahashi; Takahisa Sasaki; Nobuyuki Udagawa; Sakae Tanaka; I Nakamura; D Zhang; A Barbier; Toshio Suda
A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders.
Bone 1995;17(2):137-44.
1995: Sakae Tanaka; Naoyuki Takahashi; Nobuyuki Udagawa; H Murakami; I Nakamura; T Kurokawa; Toshio Suda
Possible involvement of focal adhesion kinase, p125FAK, in osteoclastic bone resorption.
Journal of cellular biochemistry 1995;58(4):424-35.
1995: Sakae Tanaka; Lynn Neff; Roland Baron; J B Levy
Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways.
The Journal of biological chemistry 1995;270(24):14347-51.
1995: I Nakamura; Naoyuki Takahashi; Takahisa Sasaki; Sakae Tanaka; Nobuyuki Udagawa; H Murakami; K Kimura; Y Kabuyama; T Kurokawa; Toshio Suda
Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.
FEBS letters 1995;361(1):79-84.
1994: Naoyuki Takahashi; Nobuyuki Udagawa; Sakae Tanaka; H Murakami; I Owan; T Tamura; Toshio Suda
Postmitotic osteoclast precursors are mononuclear cells which express macrophage-associated phenotypes.
Developmental biology 1994;163(1):212-21.
1993: T Tamura; Naoyuki Takahashi; T Akatsu; Takahisa Sasaki; Nobuyuki Udagawa; Sakae Tanaka; Toshio Suda
New resorption assay with mouse osteoclast-like multinucleated cells formed in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(8):953-60.
1993: Toshio Suda; Sakae Tanaka; Naoyuki Takahashi
Macrophage colon-stimulating factor (M-CSF) is essential for differentiation rather than proliferation of osteoclast progenitors.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1993;3 Suppl 1():111-3.
1993: Sakae Tanaka; Naoyuki Takahashi; Nobuyuki Udagawa; T Tamura; T Akatsu; E Richard Stanley; T Kurokawa; Toshio Suda
Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.
The Journal of clinical investigation 1993;91(1):257-63.
1992: Sakae Tanaka; Naoyuki Takahashi; Nobuyuki Udagawa; Takahisa Sasaki; Y Fukui; T Kurokawa; Toshio Suda
Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes.
FEBS letters 1992;313(1):85-9.
1992: T Akatsu; T Tamura; Naoyuki Takahashi; Nobuyuki Udagawa; Sakae Tanaka; Takahisa Sasaki; A Yamaguchi; N Nagata; Toshio Suda
Preparation and characterization of a mouse osteoclast-like multinucleated cell population.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(11):1297-306.
1992: Nobuyuki Udagawa; Takahisa Sasaki; T Akatsu; Naoyuki Takahashi; Sakae Tanaka; T Tamura; Hiromichi Tanaka; Toshio Suda
Lack of bone resorption in osteosclerotic (oc/oc) mice is due to a defect in osteoclast progenitors rather than the local microenvironment provided by osteoblastic cells.
Biochemical and biophysical research communications 1992;184(1):67-72.