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Lena Al-Harthi

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TOP 3
Lena Al-Harthi
Wnt/β-catenin and its diverse physiological cell signaling pathways in neurodegenerative and neuropsychiatric disorders.
Lena Al-Harthi
Interplay between Wnt/β-catenin signaling and HIV: virologic and biologic consequences in the CNS.
Lisa J Henderson; Eugene O Major; Maria Chiara G Monaco; Amit Sharma; Lena Al-Harthi
Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt/β-catenin signaling in astrocytes: relevance to HIV neuropathogenesis.

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All Publications

2012: Lena Al-Harthi
Wnt/β-catenin and its diverse physiological cell signaling pathways in neurodegenerative and neuropsychiatric disorders.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012;7(4):725-30.
2012: Lena Al-Harthi
Interplay between Wnt/β-catenin signaling and HIV: virologic and biologic consequences in the CNS.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012;7(4):731-9.
2012: Lisa J Henderson; Eugene O Major; Maria Chiara G Monaco; Amit Sharma; Lena Al-Harthi
Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt/β-catenin signaling in astrocytes: relevance to HIV neuropathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(46):16306-13.
2012: Lisa J Henderson; Fatah Kashanchi; Srinivas D Narasipura; Vyacheslav Adarichev; Lena Al-Harthi
Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, β-catenin, and SMAR1 to repress HIV transcription.
Journal of virology 2012;86(17):9495-503.
2012: Lena Al-Harthi
Comment on "CD4+ CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection".
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):5809; author reply 5809-10.
2012: Andrew Zloza; Lena Al-Harthi; Emily Bellavance; Michael C Jagoda; Frederick J Kohlhapp; Andrew T Lacek; Gretchen E Lyons; Amanda L Marzo; Tamson V Moore; Jeremy A O'Sullivan; Bojan Polić; Jason M Schenkel; Anne I Sperling; Paul Thomas; Vineeth varanasi; Jesse W Williams; Biljana Zafirova; José A Guevara-Patiño
NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responses.
Nature medicine 2012;18(3):422-8.
2012: Srinivas D Narasipura; Liang Chen; Sidney W Fu; Lisa J Henderson; Fatah Kashanchi; Lena Al-Harthi
Role of β-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes.
Journal of virology 2012;86(4):1911-21.
2011: Lena Al-Harthi; Fatah Kashanchi
Mechanisms of HIV-1 latency post HAART treatment area.
Current HIV research 2011;9(8):552-3.
2011: Amit Sharma; Xiu-Ti Hu; T Celeste Napier; Lena Al-Harthi
Methamphetamine and HIV-1 Tat down regulate β-catenin signaling: implications for methampetamine abuse and HIV-1 co-morbidity.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2011;6(4):597-607.
2011: Wei Li; Eugene O Major; Lisa J Henderson; Lena Al-Harthi
IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(12):6771-8.
2011: Lisa J Henderson; Lena Al-Harthi
Role of β-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2011;6(2):247-59.
2010: Jason M Schenkel; Andrew Zloza; Wei Li; Srinivas D Narasipura; Lena Al-Harthi
Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(4):2013-9.
2010: Andrea Kovacs; Roksana Karim; Wendy J Mack; Jiaao Xu; Zhi Chen; Eva A Operskalski; Toni Frederick; Alan Landay; John Voris; La Shonda Spencer; Mary A Young; Phyllis C Tien; Michael Augenbraun; Howard D Strickler; Lena Al-Harthi
Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus.
The Journal of infectious diseases 2010;201(6):823-34.
2009: Andrew Zloza; Jason M Schenkel; Allan Tenorio; Jeffrey A Martinson; Paul M Jeziorczak; Lena Al-Harthi
Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface.
Blood 2009;114(18):3841-53.
2008: Andrea Kovacs; Lena Al-Harthi; Shawna Christensen; Wendy Mack; Mardge Cohen; Alan Landay
CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus.
The Journal of infectious diseases 2008;197(10):1402-7.
2008: Anvita Kumar; Andrew Zloza; Randall T Moon; Jeffrey Watts; Allan Tenorio; Lena Al-Harthi
Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells.
Journal of virology 2008;82(6):2813-20.
2007: Lena Al-Harthi; Sam MaWhinney; Elizabeth Connick; Robert T Schooley; Jeri E Forster; Constance Benson; Melanie Thompson; Franklyn N Judson; Frank J Palella; Alan Landay
Immunophenotypic alterations in acute and early HIV infection.
Clinical immunology (Orlando, Fla.) 2007;125(3):299-308.
2007: Deborah Carroll-Anzinger; Anvita Kumar; Vyacheslav Adarichev; Fatah Kashanchi; Lena Al-Harthi
Human immunodeficiency virus-restricted replication in astrocytes and the ability of gamma interferon to modulate this restriction are regulated by a downstream effector of the Wnt signaling pathway.
Journal of virology 2007;81(11):5864-71.
2007: Jeffrey A Martinson; Allan Tenorio; Carlos J Montoya; Lena Al-Harthi; Carolyne N Gichinga; Arthur M Krieg; Linda L Baum; Alan L Landay
Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals.
Immunology 2007;120(4):526-35.
2007: Carrie A Sailer; Gregory B Pott; Charles A Dinarello; Samantha Ma Whinney; Jeri E Forster; Jacqueline K Larson-Duran; Alan Landay; Lena Al-Harthi; Robert T Schooley; Constance A Benson; Franklyn N Judson; Melanie Thompson; Frank J Palella; Leland Shapiro
Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels.
The Journal of infectious diseases 2007;195(5):734-8.
2007: Bouchaib Bahbouhi; Alan Landay; Allan Tenorio; Lena Al-Harthi
HIV infection of primary CD4+ Th2 cells, defined by expression of the chemoattractant receptor-homologous (CRTH2), induces a Th0 phenotype.
AIDS research and human retroviruses 2007;23(2):269-77.
2007: Tomasz Laskus; Eva A Operskalski; Marek Radkowski; Jeffrey Wilkinson; Wendy Mack; Marina Degiacomo; Lena Al-Harthi; Zhi Chen; Jiaao Xu; Andrea Kovacs
Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV-positive/HIV-infected women.
The Journal of infectious diseases 2007;195(1):124-33.
2006: Carlos J Montoya; Hyun-Bae Jie; Lena Al-Harthi; Candice Mulder; Pablo Patino; Maria T Rugeles; Arthur M Krieg; Alan L Landay; S Brian Wilson
Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1028-39.
2006: Elizabeth Z Managlia; Alan Landay; Lena Al-Harthi
Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell (NFAT)-dependent pathway.
Virology 2006;350(2):443-52.
2006: Lena Al-Harthi; John C Voris; Wenbo Du; David Wright; Marek Nowicki; Toni Frederick; Alan Landay; Andrea Kovacs
Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells.
The Journal of infectious diseases 2006;193(9):1202-10.
2006: Andrew Zloza; Lena Al-Harthi
Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration.
Journal of leukocyte biology 2006;79(1):4-6.
2006: Deborah Carroll-Anzinger; Lena Al-Harthi
Gamma interferon primes productive human immunodeficiency virus infection in astrocytes.
Journal of virology 2006;80(1):541-4.
2005: Elizabeth Z Managlia; Alan Landay; Lena Al-Harthi
Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells.
Immunology 2005;114(3):322-35.
2004: Michelle J De Vera; Lena Al-Harthi; Anita T Gewurz
Assessing thymopoiesis in patients with common variable immunodeficiency as measured by T-cell receptor excision circles.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2004;93(5):478-84.
2004: Elizabeth Z Managlia; Deborah Carroll; Andrew Zloza; Lena Al-Harthi
Immune modulation of HIV replication: relevance to HIV immuno- and neuro-pathogenesis.
Current HIV research 2004;2(4):395-401.
2004: Bouchaib Bahbouhi; Alan Landay; Lena Al-Harthi
Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells.
Blood 2004;103(12):4581-7.
2004: Bouchaib Bahbouhi; Lena Al-Harthi
Enriching for HIV-infected cells using anti-gp41 antibodies indirectly conjugated to magnetic microbeads.
BioTechniques 2004;36(1):139-47.
2004: Lena Al-Harthi; John C Voris; B K Patterson; STANLEY BECKER; Joseph J Eron; Kimberly Y Smith; R D'Amico; Donna Mildvan; J Snidow; B Pobiner; Linda Yau; Alan Landay
Evaluation of the impact of highly active antiretroviral therapy on immune recovery in antiretroviral naive patients.
HIV medicine 2004;5(1):55-65.
2003: Jeffrey M Jacobson; Michael M Lederman; John Spritzler; Hernan Valdez; Pablo Tebas; Gail Skowron; Rui Wang; J Brooks Jackson; Lawrence Fox; Alan Landay; Mark J Gilbert; Dorothy O'Neil; Lynne Bancroft; Lena Al-Harthi; Mark A Jacobson; Thomas C Merigan; Marshall J Glesby
Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection.
The Journal of infectious diseases 2003;188(12):1804-14.
2003: Andrew Zloza; Yvonne B Sullivan; Elizabeth Connick; Alan L Landay; Lena Al-Harthi
CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV.
Blood 2003;102(6):2156-64.
2003: Miriam C Poirier; Rao L Divi; Lena Al-Harthi; Ofelia A Olivero; Vi Nguyen; Brettania Walker; Alan L Landay; Vernon E Walker; Man E Charurat; William A Blattner
Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers.
Journal of acquired immune deficiency syndromes (1999) 2003;33(2):175-83.
2003: Richardson Fleuridor; Brian Wilson; Runhua Hou; Alan Landay; Harold Kessler; Lena Al-Harthi
CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection.
Immunology 2003;108(1):3-9.
2002: Mostafa Nokta; Xiao-Dong Li; Lena Al-Harthi; Joan Nichols; Anna M Pou; David M Asmuth; Alan Landay; Richard B Pollard
Entrapment of recent thymic emigrants in lymphoid tissues from HIV-infected patients: association with HIV cellular viral load.
AIDS (London, England) 2002;16(16):2119-27.
2002: Lena Al-Harthi; Alan Landay
Immune recovery in HIV disease: role of the thymus and T cell expansion in immune reconstitution strategies.
Journal of hematotherapy & stem cell research 2002;11(5):777-86.
2002: Carolyn M Steffens; Elizabeth Z Managlia; Alan Landay; Lena Al-Harthi
Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1.
Blood 2002;99(9):3310-8.
2002: Kimberly Y Smith; Carolyn M Steffens; Allison Truckenbrod; Alan Landay; Lena Al-Harthi
Immune reconstitution after successful treatment with protease inhibitor-based and protease inhibitor-sparing antiretroviral regimens.
Journal of acquired immune deficiency syndromes (1999) 2002;29(5):544-5.
2002: Lena Al-Harthi; Larry J Guilbert; James A Hoxie; Alan Landay
Trophoblasts are productively infected by CD4-independent isolate of HIV type 1.
AIDS research and human retroviruses 2002;18(1):13-7.
2001: Carolyn M Steffens; Kimberly Y Smith; Alan Landay; Susan Shott; A Truckenbrod; M Russert; Lena Al-Harthi
T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals.
AIDS (London, England) 2001;15(14):1757-64.
2001: Lena Al-Harthi; Andrea Kovacs; Robert W Coombs; Patricia Reichelderfer; David J Wright; M H Cohen; Jonathan A Cohn; Susan Cu-Uvin; Heather Watts; S Lewis; Suzanne K Beckner; Alan Landay
A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding.
AIDS (London, England) 2001;15(12):1535-43.
2001: Y B Sullivan; Alan L Landay; J A Zack; Scott Kitchen; Lena Al-Harthi
Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells.
Immunology 2001;103(3):270-80.
2000: Carolyn M Steffens; Lena Al-Harthi; Susan Shott; R Yogev; Alan Landay
Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and naïve phenotypes.
Clinical immunology (Orlando, Fla.) 2000;97(2):95-101.
2000: Lena Al-Harthi; David J Wright; D Anderson; M Cohen; D Matity Ahu; Jonathan A Cohn; S Cu-Unvin; D Burns; Patricia Reichelderfer; S Lewis; Suzanne K Beckner; Andrea Kovacs; Alan Landay
The impact of the ovulatory cycle on cytokine production: evaluation of systemic, cervicovaginal, and salivary compartments.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(8):719-24.
2000: Lena Al-Harthi; J Siegel; John Spritzler; J Pottage; M Agnoli; Alan Landay
Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease.
AIDS (London, England) 2000;14(7):761-70.
2000: Lena Al-Harthi; G Marchetti; Carolyn M Steffens; J Poulin; R Sékaly; Alan Landay
Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA).
Journal of immunological methods 2000;237(1-2):187-97.
1999: Lena Al-Harthi; Kenneth A Roebuck; Gene Garrard Olinger; Alan Landay; BE Sha; Farhad B Hashemi; Gregory T Spear
Bacterial vaginosis-associated microflora isolated from the female genital tract activates HIV-1 expression.
Journal of acquired immune deficiency syndromes (1999) 1999;21(3):194-202.
1998: MF Rabbi; Alison Finnegan; Lena Al-Harthi; S Song; Kenneth A Roebuck
Interleukin-10 enhances tumor necrosis factor-alpha activation of HIV-1 transcription in latently infected T cells.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;19(4):321-31.
1998: Lena Al-Harthi; Gregory T Spear; Farhad B Hashemi; Alan Landay; BE Sha; Kenneth A Roebuck
A human immunodeficiency virus (HIV)-inducing factor from the female genital tract activates HIV-1 gene expression through the kappaB enhancer.
The Journal of infectious diseases 1998;178(5):1343-51.
1998: MF Rabbi; Lena Al-Harthi; Mohammed Saifuddin; Kenneth A Roebuck
The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage.
Virology 1998;245(2):257-69.
1998: Lena Al-Harthi; Kenneth A Roebuck
Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review).
International journal of molecular medicine 1998;1(5):875-81.
1998: Lena Al-Harthi; Kenneth A Roebuck; A Landay
Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL)-12 and IL-15: effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production.
Journal of clinical immunology 1998;18(2):124-31.
1998: Hernan Valdez; Lena Al-Harthi; A Landay; M M Lederman
Rationale for immune-based therapies for HIV-1 infection.
The Journal of laboratory and clinical medicine 1998;131(3):197-206.
1998: Lena Al-Harthi; M Owais; Suresh K Arya
Molecular inhibition of HIV type 1 by HIV type 2: effectiveness in peripheral blood mononuclear cells.
AIDS research and human retroviruses 1998;14(1):59-64.
1997: Lena Al-Harthi; Kenneth A Roebuck; H Kessler; Alan Landay
Inhibition of cytokine-driven human immunodeficiency virus type 1 replication by protease inhibitor.
The Journal of infectious diseases 1997;176(5):1175-9.
1997: MF Rabbi; Lena Al-Harthi; Kenneth A Roebuck
TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements.
Virology 1997;237(2):422-9.
1997: Gregory T Spear; Lena Al-Harthi; Beverly E Sha; MN Saarloos; M Hayden; LS Massad; Constance Benson; Kenneth A Roebuck; N R Glick; Alan Landay
A potent activator of HIV-1 replication is present in the genital tract of a subset of HIV-1-infected and uninfected women.
AIDS (London, England) 1997;11(11):1319-26.
1997: Anthony D Kelleher; Lena Al-Harthi; Alan L Landay
Immunological effects of antiretroviral and immune therapies for HIV.
AIDS (London, England) 1997;11 Suppl A():S149-55.