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warren kruger

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Baiqing Tang; Joseph R Testa; warren kruger
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.
Daqing Zhang; Xiaofeng Yang; Remus M Berretta; Pu Fang; Steven R Houser; Xiaohua Jiang; warren kruger; Jodene K Moore; Jun Nelson; Hong Wang
Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice.
Sanjana Dayal; Frank M Faraci; Melissa Jensen; warren kruger; Lorie Leo; Cynthia M Lynch; Anil K Chauhan; Steven R Lentz
Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia.

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All Publications

2012: Baiqing Tang; Joseph R Testa; warren kruger
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.
Cancer biology & therapy 2012;13(11):1082-90.
2012: Daqing Zhang; Xiaofeng Yang; Remus M Berretta; Pu Fang; Steven R Houser; Xiaohua Jiang; warren kruger; Jodene K Moore; Jun Nelson; Hong Wang
Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice.
Circulation research 2012;111(1):37-49.
2012: Sanjana Dayal; Frank M Faraci; Melissa Jensen; warren kruger; Lorie Leo; Cynthia M Lynch; Anil K Chauhan; Steven R Lentz
Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia.
Blood 2012;119(13):3176-83.
2012: Diana Zitserman; Sapna Gupta; Magdalena Karbowniczek; warren kruger; Fabrice Roegiers
The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis.
PloS one 2012;7(11):e48720.
2012: Vinciane Régnier; Guido Vacano; Stéphanie Woerner; Sabrina Luilier; Evelyne Paly; David Patterson; Brigitte Potier; Jean-Marie Billard; Jean-Charles Bizot; Sabrina David; Jean-Maurice Delabar; Sapna Gupta; Jan P Kraus; warren kruger; Aurélie Ledru; Jaqueline London
Brain phenotype of transgenic mice overexpressing cystathionine β-synthase.
PloS one 2012;7(1):e29056.
2011: Aladdin Mustafa; Robert G Uzzo; Brian L Egleston; Sapna Gupta; Gary R Hudes; warren kruger
Serum amino acid levels as a biomarker for renal cell carcinoma.
The Journal of urology 2011;186(4):1206-12.
2011: Zhongjian Cheng; William Durante; Sapna Gupta; Xiaohua Jiang; warren kruger; Muniswamy Madesh; Karthik Mallilankaraman; Domenico Praticò; Andrew I Schafer; Xiaofeng Yang; Hong Wang
Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice.
Blood 2011;118(7):1998-2006.
2011: Jana Strakova; Katherine Tryon; Ryan N Dilger; Sapna Gupta; warren kruger; Lucas Li; Timothy A Garrow
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity.
Nutrition research (New York, N.Y.) 2011;31(7):563-71.
2011: Sapna Gupta; warren kruger
Cystathionine beta-synthase deficiency causes fat loss in mice.
PloS one 2011;6(11):e27598.
2011: Yuwaraj Kadariya; Baiqing Tang; Cynthia B Myers; Jami Fukui; Jeffrey Peterson; warren kruger
Chemical genetic screening for compounds that preferentially inhibit growth of methylthioadenosine phosphorylase (MTAP)-deficient Saccharomyces cerevisiae.
Journal of biomolecular screening 2011;16(1):44-52.
2010: Baiqing Tang; Aladdin Mustafa; Sapna Gupta; Stepan Melnyk; S Jill James; warren kruger
Methionine-deficient diet induces post-transcriptional downregulation of cystathionine β-synthase.
Nutrition (Burbank, Los Angeles County, Calif.) 2010;26(11-12):1170-5.
2010: Jana Strakova; Kelly T Williams; Sapna Gupta; Kevin L Schalinske; warren kruger; Rima Rozen; Jiri Jiracek; Lucas Li; Timothy A Garrow
Dietary intake of S-(alpha-carboxybutyl)-DL-homocysteine induces hyperhomocysteinemia in rats.
Nutrition research (New York, N.Y.) 2010;30(7):492-500.
2010: Qiong Wei; Liqun Wang; Qiang Wang; warren kruger; Roland Dunbrack
Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase.
Proteins 2010;78(9):2058-74.
2010: J-M Zhuo; G S Portugal; warren kruger; H Wang; T J Gould; D Pratico
Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's disease.
Current Alzheimer research 2010;7(2):140-9.
2010: Jia-Min Zhuo; warren kruger; Domenico Pratico'
The Herp protein pathway is not involved in the pro-amyloidogenic effect of hyperhomocysteinemia.
Journal of Alzheimer's disease : JAD 2010;20(2):569-76.
2010: Laishram R Singh; Sapna Gupta; Nicholaas H Honig; Jan P Kraus; warren kruger
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70.
PLoS genetics 2010;6(1):e1000807.
2009: Daqing Zhang; Xiaohua Jiang; Pu Fang; Yan Yan; Jian Song; Sapna Gupta; Andrew I Schafer; William Durante; warren kruger; Xiaofeng Yang; Hong Wang
Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice.
Circulation 2009;120(19):1893-902.
2009: Yuwaraj Kadariya; Bu Yin; Baiqing Tang; Susan A Shinton; Eoin P Quinlivan; Xiang Hua; Andres Klein-Szanto; Tahseen Al-Saleem; Craig H Bassing; Richard R Hardy; warren kruger
Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.
Cancer research 2009;69(14):5961-9.
2009: Hieronim Jakubowski; Joanna Perla-Kajan; Richard H Finnell; Robert M Cabrera; Hong Wang; Sapna Gupta; warren kruger; Jan P Kraus; Diana M Shih
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(6):1721-7.
2009: Sapna Gupta; Jirko Kühnisch; Aladdin Mustafa; Sarka Lhotak; Alexander Schlachterman; Michael J Slifker; Andres Klein-Szanto; Katherine A High; Richard C Austin; warren kruger
Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(3):883-93.
2009: Laishram R Singh; warren kruger
Functional rescue of mutant human cystathionine beta-synthase by manipulation of Hsp26 and Hsp70 levels in Saccharomyces cerevisiae.
The Journal of biological chemistry 2009;284(7):4238-45.
2008: Tomas Majtan; Laishram R Singh; Liqun Wang; warren kruger; Jan P Kraus
Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone.
The Journal of biological chemistry 2008;283(50):34588-95.
2008: Marc Roy; Daniel Leclerc; Qing Wu; Sapna Gupta; warren kruger; Rima Rozen
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency.
Journal of cellular biochemistry 2008;105(2):467-76.
2008: Aladdin Mustafa; warren kruger
Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(15):4935-42.
2008: Sapna Gupta; Liqun Wang; Xiang Hua; Jakub Krijt; Viktor Kozich; warren kruger
Cystathionine beta-synthase p.S466L mutation causes hyperhomocysteinemia in mice.
Human mutation 2008;29(8):1048-54.
2007: Marjon van Slegtenhorst; Damir Khabibullin; Tiffiney R Hartman; Emmanuelle Nicolas; warren kruger; Elizabeth Petri Henske
The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.
The Journal of biological chemistry 2007;282(34):24583-90.
2007: Laishram R Singh; Xulin Chen; Viktor Kozich; warren kruger
Chemical chaperone rescue of mutant human cystathionine beta-synthase.
Molecular genetics and metabolism 2007;91(4):335-42.
2006: Eun-Sook Park; Hyun-Jeong Oh; warren kruger; Sung-Chul Jung; Jin-Sung Lee
Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria.
Experimental & molecular medicine 2006;38(6):652-61.
2006: Jianming Pei; warren kruger; Joseph R Testa
High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays.
Cancer genetics and cytogenetics 2006;170(1):65-8.
2006: Baiqing Tang; Yuwaraj Kadariya; Maureen E Murphy; warren kruger
The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase.
Biochemical pharmacology 2006;72(7):806-15.
2006: Xiaowei Chen; Liqun Wang; R Fazlieva; warren kruger
Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response.
Human mutation 2006;27(5):474-82.
2005: Liqun Wang; Xulin Chen; Baiqing Tang; Xiang Hua; Andres Klein-Szanto; warren kruger
Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model.
Human molecular genetics 2005;14(15):2201-8.
2005: Kwang-Hwan Jhee; warren kruger
The role of cystathionine beta-synthase in homocysteine metabolism.
Antioxidants & redox signaling 2005;7(5-6):813-22.
2005: Yuwaraj Kadariya; Kaname Nakatani; Junji Nishioka; Takahiko Fujikawa; warren kruger; Tsutomu Nobori
Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor)/NF-Y (nuclear factor-Y).
The Biochemical journal 2005;387(Pt 1):175-83.
2004: Xulin Chen; Kwang-Hwan Jhee; warren kruger
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
The Journal of biological chemistry 2004;279(50):52082-6.
2004: Ahmad L Subhi; Baiqing Tang; binaifer Balsara; Deborah A Altomare; Joseph R Testa; Harry S Cooper; John P Hoffman; Neal J Meropol; warren kruger
Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(21):7290-6.
2004: Sinoula Apostolou; Julian O Klein; Yasuhiro Mitsuuchi; Justin N Shetler; Poulikos I Poulikakos; Suresh C Jhanwar; warren kruger; Joseph R Testa
Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype.
Oncogene 2004;23(29):5032-40.
2004: Liqun Wang; Kwang-Hwan Jhee; Xiang Hua; Patricia M DiBello; Donald W Jacobsen; warren kruger
Modulation of cystathionine beta-synthase level regulates total serum homocysteine in mice.
Circulation research 2004;94(10):1318-24.
2004: Marjon van Slegtenhorst; Erikka Carr; Radka Stoyanova; warren kruger; Elizabeth Petri Henske
Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.
The Journal of biological chemistry 2004;279(13):12706-13.
2004: Rani H Singh; warren kruger; Liqun Wang; Marzia Pasquali; Louis J Elsas
Cystathionine beta-synthase deficiency: effects of betaine supplementation after methionine restriction in B6-nonresponsive homocystinuria.
Genetics in medicine : official journal of the American College of Medical Genetics 2004;6(2):90-5.
2004: Baiqing Tang; warren kruger; Gang Chen; Fumin Shen; Wen Yao Lin; Souleymane MBoup; W Thomas London; Alison A Evans
Hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in chronic carriers.
Journal of medical virology 2004;72(1):35-40.
2003: Ahmad L Subhi; Paula Diegelman; Carl W Porter; Baiqing Tang; Zichun J Lu; George D Markham; warren kruger
Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites.
The Journal of biological chemistry 2003;278(50):49868-73.
2003: warren kruger; Liqun Wang; Kwang-Hwan Jhee; Rani H Singh; Louis J Elsas
Cystathionine beta-synthase deficiency in Georgia (USA): correlation of clinical and biochemical phenotype with genotype.
Human mutation 2003;22(6):434-41.
2003: Myeong Sook Cheon; M Bajo; Seong Hwan Kim; J O Claudio; A K Stewart; D Patterson; warren kruger; H Kondoh; Gert Lubec
Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part II).
Amino acids 2003;24(1-2):119-25.
2002: Scott A Christopher; Paula Diegelman; Carl W Porter; warren kruger
Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line.
Cancer research 2002;62(22):6639-44.
2002: Scott A Christopher; Stepan Melnyk; S Jill James; warren kruger
S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine beta-synthase.
Molecular genetics and metabolism 2002;75(4):335-43.
2001: Anne Berit Guttormsen; Per Magne Ueland; warren kruger; C E Kim; L Ose; Ivar Følling; Helga Refsum
Disposition of homocysteine in subjects heterozygous for homocystinuria due to cystathionine beta-synthase deficiency: relationship between genotype and phenotype.
American journal of medical genetics 2001;100(3):204-13.
2001: X Shan; Roland L Dunbrack; Scott A Christopher; warren kruger
Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis.
Human molecular genetics 2001;10(6):635-43.
2001: Tomoyoshi Nozaki; Yasuo Shigeta; Yumiko Saito-Nakano; M Imada; warren kruger
Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma.
The Journal of biological chemistry 2001;276(9):6516-23.
2001: M Rene Malinow; P Barton Duell; M A Williams; warren kruger; Alison A Evans; PH Anderson; PC Block; David L Hess; Barbara M Upson; EE Graf; A Irvin-Jones; Liqun Wang
Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations.
Lipids 2001;36 Suppl():S27-32.
2001: G D Strizheva; T Carsillo; warren kruger; E J Sullivan; J H Ryu; Elizabeth Petri Henske
The spectrum of mutations in TSC1 and TSC2 in women with tuberous sclerosis and lymphangiomyomatosis.
American journal of respiratory and critical care medicine 2001;163(1):253-8.
2000: Baiqing Tang; Y N Li; warren kruger
Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth.
Cancer research 2000;60(19):5543-7.
2000: warren kruger; Alison A Evans; Liqun Wang; M Rene Malinow; P Barton Duell; PH Anderson; PC Block; David L Hess; EE Graf; Barbara M Upson
Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid.
Molecular genetics and metabolism 2000;70(1):53-60.
2000: warren kruger
Vitamins and homocysteine metabolism.
Vitamins and hormones 2000;60():333-52.
1999: X Shan; Liqun Wang; R Hoffmaster; warren kruger
Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae.
The Journal of biological chemistry 1999;274(46):32613-8.
1999: A Lobo; Arabi Naso; Kristopher L Arheart; warren kruger; T Abou-Ghazala; F Alsous; Maher Nahlawi; A Gupta; A Moustapha; Frederick Van Lente; Donald W Jacobsen; Killian Robinson
Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12.
The American journal of cardiology 1999;83(6):821-5.
1999: P Chen; Ranjana Poddar; E V Tipa; Patricia M DiBello; C D Moravec; Killian Robinson; Ralph Green; warren kruger; T A Garrow; Donald W Jacobsen
Homocysteine metabolism in cardiovascular cells and tissues: implications for hyperhomocysteinemia and cardiovascular disease.
Advances in enzyme regulation 1999;39():93-109.
1999: Jan P Kraus; Miroslav Janosík; Viktor Kozich; R Mandell; Vivian E Shih; Maria Pia Sperandeo; Gianfranco Sebastio; Raffaella de Franchis; Generoso Andria; Leo A J Kluijtmans; H Blom; Godfried H J Boers; Ross B Gordon; P Kamoun; M Y Tsai; warren kruger; Hans Georg Koch; T Ohura; Mette Gaustadnes
Cystathionine beta-synthase mutations in homocystinuria.
Human mutation 1999;13(5):362-75.
1998: Shinichi Taoka; S Ohja; X Shan; warren kruger; Ruma Banerjee
Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity.
The Journal of biological chemistry 1998;273(39):25179-84.
1998: X Shan; warren kruger
Correction of disease-causing CBS mutations in yeast.
Nature genetics 1998;19(1):91-3.
1998: M Rene Malinow; P Barton Duell; David L Hess; PH Anderson; warren kruger; B E Phillipson; R A Gluckman; PC Block; Barbara M Upson
Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease.
The New England journal of medicine 1998;338(15):1009-15.
1997: C E Kim; P M Gallagher; Anne Berit Guttormsen; H Refsum; Per Magne Ueland; L Ose; I Folling; A S Whitehead; M Y Tsai; warren kruger
Functional modeling of vitamin responsiveness in yeast: a common pyridoxine-responsive cystathionine beta-synthase mutation in homocystinuria.
Human molecular genetics 1997;6(13):2213-21.
1997: M Rene Malinow; F Javier Nieto; warren kruger; P Barton Duell; David L Hess; R A Gluckman; PC Block; C R Holzgang; PH Anderson; D Seltzer; Barbara M Upson; Q R Lin
The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(6):1157-62.
1996: S Gulati; P Baker; Y N Li; B Fowler; warren kruger; L C Brody; Ruma Banerjee
Defects in human methionine synthase in cblG patients.
Human molecular genetics 1996;5(12):1859-65.
1996: Y N Li; S Gulati; P J Baker; L C Brody; Ruma Banerjee; warren kruger
Cloning, mapping and RNA analysis of the human methionine synthase gene.
Human molecular genetics 1996;5(12):1851-8.
1995: warren kruger; C L Peterson; Anita Sil; C Coburn; G Arents; E N Moudrianakis; Ira Herskowitz
Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.
Genes & development 1995;9(22):2770-9.
1995: warren kruger; D R Cox
A yeast assay for functional detection of mutations in the human cystathionine beta-synthase gene.
Human molecular genetics 1995;4(7):1155-61.
1994: warren kruger; D R Cox
A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6614-8.
1991: warren kruger; Ira Herskowitz
A negative regulator of HO transcription, SIN1 (SPT2), is a nonspecific DNA-binding protein related to HMG1.
Molecular and cellular biology 1991;11(8):4135-46.
1991: C L Peterson; warren kruger; Ira Herskowitz
A functional interaction between the C-terminal domain of RNA polymerase II and the negative regulator SIN1.
Cell 1991;64(6):1135-43.
1987: A J DiBenedetto; D M Lakich; warren kruger; J M Belote; B S Baker; Mariana F Wolfner
Sequences expressed sex-specifically in Drosophila melanogaster adults.
Developmental biology 1987;119(1):242-51.