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Wim Timens

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Hoeke A Baarsma; Lilian Hjm Engelbertink; Huib Am Kerstjens; Mark H Menzen; Herman Meurs; Dirkje S Postma; Wim Timens; Lonneke J van Hees; Reinoud Gosens
Glycogen synthase kinase-3 (GSK-3) regulates TGF-β1 -induced differentiation of pulmonary fibroblasts.
Katrina Steiling; Peter J Sterk; Wim Timens; Maarten van den Berge; Ji Xiao; Xiaohui Zhang; Yuriy O Alekseyev; Andrea H Bild; Joshua Campbell; Jeffrey T Chang; Harvey O Coxson; Eduard Drizik; Grant Duclos; Charles Dumont; Roberta Florido; Pieter S Hiemstra; Kahkeshan Hijazi; James C Hogg; Stephen Lam; Gang Liu; Annette McWilliams; George T O'Connor; Peter Pare; Catalina Perdomo; Dirkje S Postma; Paola Sebastiani; Huiqing Si; Don Sin; Avrum Spira; Marc E Lenburg
A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment.
Fatemeh Fattahi; Machteld N Hylkema; Monique E Lodewijk; Dirkje S Postma; Helen K Reddel; Wim Timens; Franke Volbeda; Martine Broekema; Nick H T Ten Hacken
Authors’ response to Persson C: primary lysis/necrosis of eosinophils and clinical control of asthma.

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2013: Hoeke A Baarsma; Lilian Hjm Engelbertink; Huib Am Kerstjens; Mark H Menzen; Herman Meurs; Dirkje S Postma; Wim Timens; Lonneke J van Hees; Reinoud Gosens
Glycogen synthase kinase-3 (GSK-3) regulates TGF-β1 -induced differentiation of pulmonary fibroblasts.
British journal of pharmacology 2013;169(3):590-603.
2013: Katrina Steiling; Peter J Sterk; Wim Timens; Maarten van den Berge; Ji Xiao; Xiaohui Zhang; Yuriy O Alekseyev; Andrea H Bild; Joshua Campbell; Jeffrey T Chang; Harvey O Coxson; Eduard Drizik; Grant Duclos; Charles Dumont; Roberta Florido; Pieter S Hiemstra; Kahkeshan Hijazi; James C Hogg; Stephen Lam; Gang Liu; Annette McWilliams; George T O'Connor; Peter Pare; Catalina Perdomo; Dirkje S Postma; Paola Sebastiani; Huiqing Si; Don Sin; Avrum Spira; Marc E Lenburg
A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment.
American journal of respiratory and critical care medicine 2013;187(9):933-42.
2013: Fatemeh Fattahi; Machteld N Hylkema; Monique E Lodewijk; Dirkje S Postma; Helen K Reddel; Wim Timens; Franke Volbeda; Martine Broekema; Nick H T Ten Hacken
Authors’ response to Persson C: primary lysis/necrosis of eosinophils and clinical control of asthma.
Thorax 2013;68(3):295-6.
2013: Despo Ierodiakonou; Gerard H Koppelman; Dirkje S Postma; Nick H T Ten Hacken; Wim Timens; H Marike Boezen; Jorrit Gerritsen; Judith M Vonk
TGF-β1 polymorphisms and asthma severity, airway inflammation, and remodeling.
The Journal of allergy and clinical immunology 2013;131(2):582-5.
2013: Lisette I Z Kunz; Thérèse S Lapperre; Thais Mauad; Dirkje S Postma; Peter J Sterk; Jolanda Strebus; Wim Timens; Simona E Budulac; Pieter S Hiemstra
Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: A Randomized, Controlled Trial.
PloS one 2013;8(5):e63430.
2013: Saskia A Overbeek; Wim Timens; Gerry T M Wagenaar; J Edwin Blalock; Saskia Braber; Johan Garssen; Paul A J Henricks; Patricia L Jackson; Pim J Koelink; Leo Koenderman; Aletta D Kraneveld; Adele T LoTam Loi; Esmaeil Mortaz; Gert Folkerts
Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?
PloS one 2013;8(1):e55612.
2013: Adèle T Lo Tam Loi; Dirkje S Postma; Wim Timens; Antoon J M Van Oosterhout; Rainer Bischoff; H Marike Boezen; Lorenza Franciosi; Irene Heijink; Roland F Hoffmann; Susan J M Hoonhorst; Leo Koenderman; Jan-Willem Lammers; Nick H T Ten Hacken
Acute and chronic inflammatory responses induced by smoking in individuals susceptible and non-susceptible to development of COPD: from specific disease phenotyping towards novel therapy. Protocol of a cross-sectional study.
BMJ open 2013;3(2):.
2013: Fatemeh Fattahi; Machteld N Hylkema; Claes-Göran Löfdahl; Dirkje S Postma; Nick H T Ten Hacken; Wim Timens; Judith M Vonk
Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study.
Respiratory research 2013;14():10.
2013: Franke Volbeda; Wim Timens; Martine Broekema; Machteld N Hylkema; Monique E Lodewijk; Dirkje S Postma; Helen K Reddel; Nick H T Ten Hacken
Clinical control of asthma associates with measures of airway inflammation.
Thorax 2013;68(1):19-24.
2012: Simona E Budulac; Pieter S Hiemstra; Lisette I Z Kunz; Thérèse S Lapperre; H Marike Boezen; Dirkje S Postma; Wim Timens; Judith M Vonk
Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD.
European journal of pharmacology 2012;696(1-3):136-42.
2012: Annechien J A Lambeck; Simon P M Lems; Caroline Roozendaal; Wim Timens; Aad P van den Berg; Wim van der Bij; Erik A M Verschuuren; Ilby Bouwman; Laura B Bungener; Michiel E Erasmus; Theo Jongsma; Bouke G Hepkema
Successful lung transplantation in the presence of pre-existing donor-specific cytotoxic HLA Class II antibodies.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2012;31(12):1301-6.
2012: Maarten van den Berge; Judith M Vonk; Margot Gosman; Pieter S Hiemstra; Huib A M Kerstjens; Lisette I Z Kunz; Thérèse S Lapperre; Jiska B Snoeck-Stroband; Peter J Sterk; Nick H T Ten Hacken; Wim Timens; Dirkje S Postma
Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;40(5):1098-105.
2012: Eef Telenga; S W Tideman; Wim Timens; N H T Ten Hacken; Huib A M Kerstjens; Dirkje S Postma; M van den Berge
Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response.
Allergy 2012;67(8):1060-8.
2012: Yohan Bossé; Corry A Brandsma; Christian Couture; Mark Elliott; Nathalie Gaudreault; James C Hogg; Philippe Joubert; Maxime Lamontagne; Vladislav Malkov; Gregory J Opiteck; Peter D Paré; Dirkje S Postma; Andrew J Sandford; Don D Sin; Wim Timens; Catherine Tribouley; Jeffrey A Tsou; Maarten van den Berge; Vivien Wong; Michel Laviolette
Molecular signature of smoking in human lung tissues.
Cancer research 2012;72(15):3753-63.
2012: Corry-Anke Brandsma; Marie Geerlings; Machteld N Hylkema; Huib A M Kerstjens; Dirkje S Postma; Wouter H van Geffen; Wim Timens
Differential switching to IgG and IgA in active smoking COPD patients and healthy controls.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;40(2):313-21.
2012: Ke Hao; James C Hogg; Gerard Koppelman; Amit Kulkarni; Maxime Lamontagne; Michel Laviolette; Vladislav Malkov; Donald W Nicholson; David C Nickle; Greg J Opiteck; Peter D Paré; Dirkje S Postma; Alise S Reicin; Andrew Sandford; Yohan Bossé; Corry-Anke Brandsma; Christian Couture; Sean P Curtis; Denise Daley; Jonathan M Derry; W Mark Elliott; Tillie L Hackett; Christine Suver; Wim Timens; Jeffrey A Tsou; Maarten van den Berge; Rupert Vessey; Chunsheng Zhang; Don D Sin
Lung eQTLs to help reveal the molecular underpinnings of asthma.
PLoS genetics 2012;8(11):e1003029.
2012: Simona E Budulac; Pieter S Hiemstra; Therese S Lapperre; Dirkje S Postma; Wim Timens; Judith M Vonk; H Marike Boezen
Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease.
PloS one 2012;7(8):e43124.
2012: Simona E Budulac; Dirkje S Postma; Mateusz Siedlinski; Wim Timens; Judith M Vonk; Marike H Boezen
Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD.
PloS one 2012;7(3):e33386.
2012: Anouk Oldenburger; Sara S Roscioni; Wim Timens; Andrew J Halayko; Esther Jansen; Harm Maarsingh; Mark H Menzen; Herman Meurs; Martina Schmidt
Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease.
PloS one 2012;7(2):e31574.
2011: Jeroen J W Liesker; Dirkje S Postma; Wim Timens; Judith M Vonk; Erik Bathoorn; Huib A M Kerstjens
Sputum inflammation predicts exacerbations after cessation of inhaled corticosteroids in COPD.
Respiratory medicine 2011;105(12):1853-60.
2011: D Ierodiakonou; Gerard H Koppelman; Dirkje S Postma; N Ten Hacken; Wim Timens; H Marike Boezen; J Gerritsen; Judith M Vonk
E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroids.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;38(5):1044-52.
2011: A Dijkstra; Gerard H Koppelman; Dirkje S Postma; Wim Timens; Cleo C van Diemen; H Marike Boezen; Marcel Bruinenberg; Judith M Vonk
SERPINE1 -675 4G/5G polymorphism is associated with asthma severity and inhaled corticosteroid response.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;38(5):1036-43.
2011: Berber Piet; Godelieve J De Bree; Barbara S Smids-Dierdorp; Chris M van der Loos; Ester B M Remmerswaal; Jan H von der Thüsen; Jan M W van Haarst; Jan P Eerenberg; Anja ten Brinke; Wim van der Bij; Wim Timens; René A W van Lier; René E Jonkers
CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung.
The Journal of clinical investigation 2011;121(6):2254-63.
2011: C A Brandsma; Huib A M Kerstjens; Marie Geerlings; Marjan Kerkhof; Machteld N Hylkema; Dirkje S Postma; Wim Timens
The search for autoantibodies against elastin, collagen and decorin in COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;37(5):1289-92.
2011: Mirjam C Boelens; Adam M Gustafson; Dirkje S Postma; Klaas Kok; Gerben van der Vries; Pieter van der Vlies; Avrum Spira; Marc E Lenburg; Marie Geerlings; Hannie Sietsma; Wim Timens; Anke Van den Berg; Harry J M Groen
A chronic obstructive pulmonary disease related signature in squamous cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2011;72(2):177-83.
2011: Barbro N Melgert; Nick H ten Hacken; Bea Rutgers; Wim Timens; Dirkje S Postma; Machteld N Hylkema
More alternative activation of macrophages in lungs of asthmatic patients.
The Journal of allergy and clinical immunology 2011;127(3):831-3.
2011: Fatemeh Fattahi; Machteld N Hylkema; Barbro N Melgert; Wim Timens; Dirkje S Postma; Nick H T Ten Hacken
Smoking and nonsmoking asthma: differences in clinical outcome and pathogenesis.
Expert review of respiratory medicine 2011;5(1):93-105.
2011: Martine Broekema; Wim Timens; Judith M Vonk; Franke Volbeda; Monique E Lodewijk; Machteld N Hylkema; Nick H T Ten Hacken; Dirkje S Postma
Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma.
American journal of respiratory and critical care medicine 2011;183(3):310-6.
2011: Hoeke A Baarsma; Lilian H J M Engelbertink; Gertruud Haitsma; Marnix R Jonker; Huib A M Kerstjens; Herman Meurs; Dirkje S Postma; Anita I R Spanjer; Wim Timens; Reinoud Gosens
Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease.
PloS one 2011;6(9):e25450.
2011: Lisette I Z Kunz; Thérèse S Lapperre; Jiska B Snoeck-Stroband; Simona E Budulac; Wim Timens; Simone van Wijngaarden; Jasmijn A Schrumpf; Klaus F Rabe; Dirkje S Postma; Peter J Sterk; Pieter S Hiemstra
Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD.
Respiratory research 2011;12():34.
2010: Martine Broekema; F Volbeda; Wim Timens; A Dijkstra; N A Lee; J J Lee; Monique E Lodewijk; Dirkje S Postma; Machteld N Hylkema; Nick H T Ten Hacken
Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1).
Respiratory medicine 2010;104(9):1254-62.
2010: M J Blacquière; Wim Timens; Anke Van den Berg; M Geerlings; Dirkje S Postma; Machteld N Hylkema
Maternal smoking during pregnancy decreases Wnt signalling in neonatal mice.
Thorax 2010;65(6):553-4.
2010: Michael A Den Bakker; Sten Willemsen; Katrien Grunberg; L Arnold Noorduijn; Matthijs F M van Oosterhout; Robert J van Suylen; Wim Timens; Bart Vrugt; Anne Wiersma-van Tilburg; Frederik B J M Thunnissen
Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability.
Histopathology 2010;56(3):356-63.
2010: Corry-Anke Brandsma; Wim Timens; Marie Geerlings; Henrike Jekel; Dirkje S Postma; Machteld N Hylkema; Huib A M Kerstjens
Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice.
BMC pulmonary medicine 2010;10():64.
2010: Franke Volbeda; Nick H T Ten Hacken; Monique E Lodewijk; Antoon Dijkstra; Machteld N Hylkema; M Broekema; Wim Timens; Dirkje S Postma
Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?
Respiratory research 2010;11():106.
2010: Simona E Budulac; Dirkje S Postma; Pieter S Hiemstra; Lisette I Z Kunz; Mateusz Siedlinski; Henriette A Smit; Judith M Vonk; Bea Rutgers; Wim Timens; H Marike Boezen
Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD.
Respiratory research 2010;11():60.
2010: Wim Timens; Bruno Murer
Perspectives in lung pathology.
Archives of pathology & laboratory medicine 2010;134(1):24-6.
2009: Martine Broekema; Nick H T Ten Hacken; Franke Volbeda; Monique E Lodewijk; Machteld N Hylkema; Dirkje S Postma; Wim Timens
Airway epithelial changes in smokers but not in ex-smokers with asthma.
American journal of respiratory and critical care medicine 2009;180(12):1170-8.
2009: Rob J van Klaveren; Matthijs Oudkerk; Mathias Prokop; Ernst T Scholten; Kristiaan Nackaerts; Rene Vernhout; Carola A van Iersel; Karien A M van den Bergh; Susan van 't Westeinde; Carlijn van der Aalst; Erik Thunnissen; Dong Ming Xu; Ying Wang; Yingru Zhao; Hester A Gietema; Bart-Jan de Hoop; Harry J M Groen; Geertruida H de Bock; Peter van Ooijen; Carla Weenink; Johny Verschakelen; Jan-Willem J Lammers; Wim Timens; Dik Willebrand; Aryan Vink; Willem Mali; Harry J de Koning
Management of lung nodules detected by volume CT scanning.
The New England journal of medicine 2009;361(23):2221-9.
2009: Mirjam C Boelens; Klaas Kok; Pieter van der Vlies; Gerben van der Vries; Hannie Sietsma; Wim Timens; Dirkje S Postma; Harry J M Groen; Anke Van den Berg
Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis.
Lung cancer (Amsterdam, Netherlands) 2009;66(3):372-8.
2009: Gerard H Koppelman; Deborah A Meyers; Timothy D Howard; S Lilly Zheng; Gregory A Hawkins; Elizabeth J Ampleford; Jianfeng Xu; Henk Koning; Marcel Bruinenberg; Ilja M Nolte; Cleo C van Diemen; H Marike Boezen; Wim Timens; Paul A Whittaker; O Colin Stine; Sheila J Barton; John W Holloway; Stephen T Holgate; Penelope E Graves; Fernando D Martinez; Antoon J van Oosterhout; Eugene R Bleecker; Dirkje S Postma
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.
American journal of respiratory and critical care medicine 2009;180(10):929-35.
2009: Thérèse S Lapperre; Jiska B Snoeck-Stroband; Margot M E Gosman; Désirée F Jansen; Annemarie van Schadewijk; Henk A Thiadens; Judith M Vonk; H Marike Boezen; Nick H T Ten Hacken; Jacob K Sont; Klaus F Rabe; Huib A M Kerstjens; Pieter S Hiemstra; Wim Timens; Dirkje S Postma; Peter J Sterk
Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial.
Annals of internal medicine 2009;151(8):517-27.
2009: Guy G Brusselle; T Demoor; Ken R Bracke; C-A Brandsma; Wim Timens
Lymphoid follicles in (very) severe COPD: beneficial or harmful?
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;34(1):219-30.
2009: Mirjam C Boelens; Anke Van den Berg; Rudolf S N Fehrmann; Marie Geerlings; Wouter K de Jong; Gerard J te Meerman; Hannie Sietsma; Wim Timens; Dirkje S Postma; Harry J M Groen
Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer.
The Journal of pathology 2009;218(2):182-91.
2009: M J Blacquière; Wim Timens; Barbro Melgert; M Geerlings; Dirkje S Postma; M N Hylkema
Maternal smoking during pregnancy induces airway remodelling in mice offspring.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(5):1133-40.
2009: Antoon Dijkstra; Dirkje S Postma; Jacobien A Noordhoek; Monique E Lodewijk; Henk F Kauffman; Nick H T Ten Hacken; Wim Timens
Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung.
Virchows Archiv : an international journal of pathology 2009;454(4):441-9.
2009: Mieke Versluis; Nick ten Hacken; Dirkje Postma; Begona Barroso; Bea Rutgers; Marie Geerlings; B W M Willemse; Wim Timens; Machteld Hylkema
Adenosine receptors in COPD and asymptomatic smokers: effects of smoking cessation.
Virchows Archiv : an international journal of pathology 2009;454(3):273-81.
2009: Corry-Anke Brandsma; Machteld N Hylkema; Marie Geerlings; Wouter H van Geffen; Dirkje S Postma; Wim Timens; Huib A M Kerstjens
Increased levels of (class switched) memory B cells in peripheral blood of current smokers.
Respiratory research 2009;10():108.
2009: Jeroen J W Liesker; Nick H Ten Hacken; Mieke Zeinstra-Smith; Steven R Rutgers; Dirkje S Postma; Wim Timens
Reticular basement membrane in asthma and COPD: similar thickness, yet different composition.
International journal of chronic obstructive pulmonary disease 2009;4():127-35.
2009: James C Hogg; Wim Timens
The pathology of chronic obstructive pulmonary disease.
Annual review of pathology 2009;4():435-59.
2008: M L J Scheer; Dirk-Jan Slebos; D H Bogchelman; Wim Timens
[Pulmonary densities following a hysterectomy, caused by benign metastatic leiomyoma].
Nederlands tijdschrift voor geneeskunde 2008;152(37):2027-31.
2008: M Versluis; M van den Berge; Wim Timens; B Luijk; B Rutgers; J-W J Lammers; Dirkje S Postma; Machteld N Hylkema
Allergen inhalation decreases adenosine receptor expression in sputum and blood of asthma patients.
Allergy 2008;63(9):1186-94.
2008: Mieke Versluis; Dirkje S Postma; Wim Timens; Machteld N Hylkema
Effects of IL-4 and IL-13 on adenosine receptor expression and responsiveness of the human mast cell line 1.
International immunopharmacology 2008;8(6):866-73.
2008: Andre Zandvoort; Dirkje S Postma; Marnix R Jonker; Jacobien A Noordhoek; Johannes T W M Vos; Wim Timens
Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD.
Respiratory research 2008;9():83.
2008: Margaretha van der Deen; Sandra Homan; Hetty Timmer-Bosscha; Rik J Scheper; Wim Timens; Dirkje S Postma; Elisabeth G de Vries
Effect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells.
International journal of chronic obstructive pulmonary disease 2008;3(3):469-75.
2008: Margot M E Gosman; Dirkje S Postma; Judith M Vonk; Bea Rutgers; Monique Lodewijk; Mieke Smith; Marjan A Luinge; Nick H T Ten Hacken; Wim Timens
Association of mast cells with lung function in chronic obstructive pulmonary disease.
Respiratory research 2008;9():64.
2008: Erik Bathoorn; Huib Kerstjens; Dirkje Postma; Wim Timens; William MacNee
Airways inflammation and treatment during acute exacerbations of COPD.
International journal of chronic obstructive pulmonary disease 2008;3(2):217-29.
2008: Corry-Anke Brandsma; Machteld N Hylkema; Barry W A van der Strate; Dirk-Jan Slebos; Marjan A Luinge; Marie Geerlings; Wim Timens; Dirkje S Postma; Huib A M Kerstjens
Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?
Respiratory research 2008;9():17.
2008: Corry-Anke Brandsma; Machteld N Hylkema; Marjan A Luinge; Marie Geerlings; Pieter A Klok; Flemming R Cassee; Wim Timens; Dirkje S Postma; Huib A M Kerstjens
Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice.
Inhalation toxicology 2008;20(2):183-9.
2008: Wouter K de Jong; Johannes L G Blaauwgeers; Michael Schaapveld; Wim Timens; Theo J Klinkenberg; Harry J M Groen
Thymic epithelial tumours: a population-based study of the incidence, diagnostic procedures and therapy.
European journal of cancer (Oxford, England : 1990) 2008;44(1):123-30.
2008: Jiska B Snoeck-Stroband; Thérèse S Lapperre; Margot M E Gosman; H Marike Boezen; Wim Timens; Nick H T Ten Hacken; Jacob K Sont; Peter J Sterk; Pieter S Hiemstra
Chronic bronchitis sub-phenotype within COPD: inflammation in sputum and biopsies.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(1):70-7.
2007: Barbro Melgert; Wim Timens; Huib A M Kerstjens; Marie Geerlings; Marjan A Luinge; Jan Schouten; Dirkje S Postma; Machteld N Hylkema
Effects of 4 months of smoking in mice with ovalbumin-induced airway inflammation.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(12):1798-808.
2007: H S Schipper; Bea Rutgers; Minke G Huitema; Samuel Etuaful; B Daan Westenbrink; Pieter C Limburg; Wim Timens; Tjip S van der Werf
Systemic and local interferon-gamma production following Mycobacterium ulcerans infection.
Clinical and experimental immunology 2007;150(3):451-9.
2007: Joanne L Wright; Dirkje S Postma; Huib A M Kerstjens; Wim Timens; Peter Whittaker; Andrew Churg
Airway remodeling in the smoke exposed guinea pig model.
Inhalation toxicology 2007;19(11):915-23.
2007: Yvonne L Douglas; Stan A J van den Broek; Peter J Wijkstra; Rienhart F E Wolf; Wim Timens; Marco C DeRuiter; Tjark Ebels
Clinical-pathologic conference in surgery for congenital and acquired cardiovascular disease: unilateral pulmonary vein stenosis with a contralateral pulmonary varix.
The Journal of thoracic and cardiovascular surgery 2007;134(2):496-501.
2007: M C Boelens; Anke Van den Berg; I Vogelzang; Jelle Wesseling; D S Postma; Wim Timens; H J M Groen
Differential expression and distribution of epithelial adhesion molecules in non-small cell lung cancer and normal bronchus.
Journal of clinical pathology 2007;60(6):608-14.
2007: I Hamming; M E Cooper; B L Haagmans; N M Hooper; R Korstanje; A D M E Osterhaus; Wim Timens; A J Turner; gerjan navis; Harry van Goor
The emerging role of ACE2 in physiology and disease.
The Journal of pathology 2007;212(1):1-11.
2007: Barbro Melgert; Anuradha Ray; Machteld N Hylkema; Wim Timens; Dirkje S Postma
Are there reasons why adult asthma is more common in females?
Current allergy and asthma reports 2007;7(2):143-50.
2007: Jeroen J W Liesker; Nick H T Ten Hacken; SR Rutgers; M Zeinstra-Smith; Dirkje S Postma; Wim Timens
Mast cell numbers in airway smooth muscle and PC20AMP in asthma and COPD.
Respiratory medicine 2007;101(5):882-7.
2007: Paul Bresser; Marion Cornelissen; Wim van der Bij; Carel J M van Noesel; Wim Timens
Idiopathic pulmonary arterial hypertension in Dutch Caucasian patients is not associated with human herpes virus-8 infection.
Respiratory medicine 2007;101(4):854-6.
2007: Thérèse S Lapperre; Jacob K Sont; Annemarie van Schadewijk; Margot M E Gosman; Dirkje S Postma; Ingeborg M Bajema; Wim Timens; Thais Mauad; Pieter S Hiemstra
Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study.
Respiratory research 2007;8():85.
2007: Margaretha van der Deen; Elisabeth G E de Vries; Hylke Visserman; Wouter Zandbergen; Dirkje S Postma; Wim Timens; Hetty Timmer-Bosscha
Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells.
Journal of biochemical and molecular toxicology 2007;21(5):243-51.
2007: Mirjam C Boelens; Gerard te Meerman; Johan H Gibcus; Tjasso Blokzijl; H Marike Boezen; Wim Timens; Dirkje S Postma; Harry J M Groen; Anke Van den Berg
Microarray amplification bias: loss of 30% differentially expressed genes due to long probe - poly(A)-tail distances.
BMC genomics 2007;8():277.
2007: Margaretha van der Deen; Wim Timens; Hetty Timmer-Bosscha; Barry W van der Strate; Rik J Scheper; Dirkje S Postma; Elisabeth G de Vries; Huib A Kerstjens
Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice.
Respiratory research 2007;8():49.
2007: Thérèse S Lapperre; Luuk N A Willems; Wim Timens; Klaus F Rabe; Pieter S Hiemstra; Dirkje S Postma; Peter J Sterk
Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD.
Chest 2007;131(1):53-9.
2006: Margaretha van der Deen; Hendrik Marks; B W M Willemse; Dirkje S Postma; Michael Müller; Egbert F Smit; George L Scheffer; Rik J Scheper; Elisabeth G E de Vries; Wim Timens
Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients.
Virchows Archiv : an international journal of pathology 2006;449(6):682-8.
2006: Konstantin Shilo; Markku Miettinen; William D Travis; Wim Timens; Rosete Nogueira; Teri J Franks
Pulmonary microcystic fibromyxoma: Report of 3 cases.
The American journal of surgical pathology 2006;30(11):1432-5.
2006: Hester van der Vaart; Dirkje S Postma; Wim Timens; Henk Kauffman; Machteld N Hylkema; Nick H T Ten Hacken
Repeated sputum inductions induce a transient neutrophilic and eosinophilic response.
Chest 2006;130(4):1157-64.
2006: W B W H Melenhorst; Marius C van den Heuvel; A Timmer; Sippie Huitema; M Bulthuis; Wim Timens; Harry van Goor
ADAM19 expression in human nephrogenesis and renal disease: associations with clinical and structural deterioration.
Kidney international 2006;70(7):1269-78.
2006: André Zandvoort; Dirkje S Postma; M R Jonker; Jacobien A Noordhoek; J T W M Vos; Ymke M van der Geld; Wim Timens
Altered expression of the Smad signalling pathway: implications for COPD pathogenesis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(3):533-41.
2006: Dirkje S Postma; Wim Timens
Remodeling in asthma and chronic obstructive pulmonary disease.
Proceedings of the American Thoracic Society 2006;3(5):434-9.
2006: André Zandvoort; Ymke M van der Geld; M R Jonker; Jacobien A Noordhoek; J T W M Vos; Jelle Wesseling; Henk Kauffman; Wim Timens; Dirkje S Postma
High ICAM-1 gene expression in pulmonary fibroblasts of COPD patients: a reflection of an enhanced immunological function.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;28(1):113-22.
2006: Eelco Fokkema; Wim Timens; Elisabeth G E de Vries; Steven de Jong; Vaclav Fidler; Coby Meijer; Harry J M Groen
Expression and prognostic implications of apoptosis-related proteins in locally unresectable non-small cell lung cancers.
Lung cancer (Amsterdam, Netherlands) 2006;52(2):241-7.
2006: Barry W A van der Strate; Dirkje S Postma; Corry-Anke Brandsma; Barbro Melgert; Marjan A Luinge; Marie Geerlings; Machteld N Hylkema; Anke Van den Berg; Wim Timens; Huib A M Kerstjens
Cigarette smoke-induced emphysema: A role for the B cell?
American journal of respiratory and critical care medicine 2006;173(7):751-8.
2006: A Dijkstra; Judith M Vonk; Hajo Jongepier; Gerard H Koppelman; Jan Schouten; Nick H T Ten Hacken; Wim Timens; Dirkje S Postma
Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex.
Thorax 2006;61(2):105-10.
2006: Thérèse S Lapperre; Dirkje S Postma; Margot M E Gosman; Jiska B Snoeck-Stroband; Nick H T Ten Hacken; Pieter S Hiemstra; Wim Timens; Peter J Sterk; Thais Mauad
Relation between duration of smoking cessation and bronchial inflammation in COPD.
Thorax 2006;61(2):115-21.
2006: Margot M E Gosman; B W M Willemse; Désirée F Jansen; Thérèse S Lapperre; A van Schadewijk; Pieter S Hiemstra; Dirkje S Postma; Wim Timens; Huib A M Kerstjens
Increased number of B-cells in bronchial biopsies in COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;27(1):60-4.
2005: B W M Willemse; Ivonne Lesman-Leegte; Wim Timens; Dirkje Postma; Nick H T Ten Hacken
High cessation rates of cigarette smoking in subjects with and without COPD.
Chest 2005;128(5):3685-7.
2005: Barbro Melgert; Dirkje S Postma; I Kuipers; Marie Geerlings; Marjan A Luinge; Barry W A van der Strate; Huib A M Kerstjens; Wim Timens; Machteld N Hylkema
Female mice are more susceptible to the development of allergic airway inflammation than male mice.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(11):1496-503.
2005: B W M Willemse; Nick H T Ten Hacken; Bea Rutgers; Ivonne Lesman-Leegte; Dirkje S Postma; Wim Timens
Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;26(5):835-45.
2005: Floris M Wachters; L S M Wong; Wim Timens; Harm H Kampinga; Harry J M Groen
ERCC1, hRad51, and BRCA1 protein expression in relation to tumour response and survival of stage III/IV NSCLC patients treated with chemotherapy.
Lung cancer (Amsterdam, Netherlands) 2005;50(2):211-9.
2005: Wouter K de Jong; Winette T A van der Graaf; Eric J van der Jagt; Theo J Klinkenberg; Harry J M Groen; Wim Timens; W Rob Douma
A 20-year-old male with thoracic pain and a lower thoracic mass. Diagnosis: intrathoracal desmoid tumour with microscopically incomplete resection.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;26(4):740-3.
2005: Ning Qu; Paul de Vos; Maaike Schelfhorst; Aalzen De Haan; Wim Timens; Jochum Prop
Integrity of airway epithelium is essential against obliterative airway disease in transplanted rat tracheas.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005;24(7):882-90.
2005: Arjen van den Berg; Mathys Kuiper; Mieke Snoek; Wim Timens; Dirkje S Postma; Henk M Jansen; René Lutter
Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-alpha in structural lung cells.
American journal of respiratory cell and molecular biology 2005;33(1):97-104.
2005: Mijke A Breukels; André Zandvoort; Ger T Rijkers; Monique E Lodewijk; Pieter A Klok; G Harms; Wim Timens
Complement dependency of splenic localization of pneumococcal polysaccharide and conjugate vaccines.
Scandinavian journal of immunology 2005;61(4):322-8.
2005: Jacobien A Noordhoek; Dirkje S Postma; Luis L Chong; Lorian Menkema; Henk Kauffman; Wim Timens; Jeannette F M van Straaten; Ymke M van der Geld
Different modulation of decorin production by lung fibroblasts from patients with mild and severe emphysema.
COPD 2005;2(1):17-25.
2005: Margaretha van der Deen; Elisabeth G E de Vries; Wim Timens; Rik J Scheper; Hetty Timmer-Bosscha; Dirkje S Postma
ATP-binding cassette (ABC) transporters in normal and pathological lung.
Respiratory research 2005;6():59.
2005: B W M Willemse; Nick H T Ten Hacken; Bea Rutgers; Dirkje S Postma; Wim Timens
Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers.
Respiratory research 2005;6():38.
2005: Hester van der Vaart; Dirkje S Postma; Wim Timens; Machteld N Hylkema; B W M Willemse; H Marike Boezen; Judith M Vonk; Dorothea M de Reus; Henk Kauffman; Nick H T Ten Hacken
Acute effects of cigarette smoking on inflammation in healthy intermittent smokers.
Respiratory research 2005;6():22.
2004: J W K van den Berg; Dirk-Jan Slebos; Dirkje S Postma; Brigitte Dijkhuizen; Gerard H Koëter; Wim Timens; Wim der van Bij; Henk Kauffman
Feasibility of sputum induction in lung transplant recipients.
Clinical transplantation 2004;18(5):605-12.
2004: B W M Willemse; Nick H T Ten Hacken; Bea Rutgers; Ivonne Lesman-Leegte; Wim Timens; Dirkje S Postma
Smoking cessation improves both direct and indirect airway hyperresponsiveness in COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;24(3):391-6.
2004: Dirk-Jan Slebos; Erik A M Verschuuren; Gerard H Koëter; Wim van Der Bij; Henk Kauffman; Dirkje S Postma; Wim Timens
Bronchoalveolar lavage in a patient with recurrence of sarcoidosis after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004;23(8):1010-3.
2004: Hester van der Vaart; Dirkje S Postma; Wim Timens; Nick H T Ten Hacken
Acute effects of cigarette smoke on inflammation and oxidative stress: a review.
Thorax 2004;59(8):713-21.
2004: Henk Kramer; Remge M Pieterman; Dirk-Jan Slebos; Wim Timens; Willem Vaalburg; Gerard H Koëter; Harry J M Groen
PET for the evaluation of pleural thickening observed on CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(6):995-8.
2004: I Hamming; Wim Timens; M L C Bulthuis; A Titia Lely; gerjan navis; Harry van Goor
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.
The Journal of pathology 2004;203(2):631-7.
2004: Barbro Melgert; Dirkje S Postma; Marie Geerlings; Marjan A Luinge; Pieter A Klok; Barry W A van der Strate; Huib A M Kerstjens; Wim Timens; Machteld N Hylkema
Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice.
American journal of respiratory cell and molecular biology 2004;30(6):880-5.
2004: B W M Willemse; Dirkje S Postma; Wim Timens; Nick H T Ten Hacken
The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(3):464-76.
2004: Jaap Oostendorp; Machteld N Hylkema; Marjan A Luinge; Marie Geerlings; Herman Meurs; Wim Timens; Johan Zaagsma; Dirkje S Postma; Hendrikus W G M Boddeke; Knut Biber
Localization and enhanced mRNA expression of the orphan chemokine receptor L-CCR in the lung in a murine model of ovalbumin-induced airway inflammation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(3):401-10.
2004: A Keijzer; Johannes M A Daniels; W A Slieker; Wim Timens; Casper S de Graaff; Wim G Boersma
[Bronchocentric granulomatosis and mycoplasmal pneumonia].
Nederlands tijdschrift voor geneeskunde 2004;148(7):332-6.
2004: M E van Albada; M J Eldering; Wendy J Post; Theo J Klinkenberg; Wim Timens; Harry J M Groen
[The biopsying of at least 5 mediastinal lymph node stations for presurgical staging in patients with a non-small-cell lung carcinoma].
Nederlands tijdschrift voor geneeskunde 2004;148(6):281-6.
2004: Frank B Niessen; Joost Schalkwijk; Hans Vos; Wim Timens
Hypertrophic scar formation is associated with an increased number of epidermal Langerhans cells.
The Journal of pathology 2004;202(1):121-9.
2003: Jan A Leeuw; Jan Koudstaal; Janneke Wiersema-Buist; Willem A Kamps; Wim Timens
Bone histomorphometry in children with newly diagnosed acute lymphoblastic leukemia.
Pediatric research 2003;54(6):814-8.
2003: Huib A M Kerstjens; Wim Timens
Phosphodiesterase 4 inhibitors: antiinflammatory therapy for chronic obstructive pulmonary disease at last?
American journal of respiratory and critical care medicine 2003;168(8):914-5.
2003: Diana C J Spierings; Elisabeth G E de Vries; Wim Timens; Harry J M Groen; H Marike Boezen; Steven de Jong
Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(9):3397-405.
2003: Jacobien A Noordhoek; Dirkje S Postma; Luis L Chong; J T W M Vos; Henk Kauffman; Wim Timens; Jeannette F M van Straaten
Different proliferative capacity of lung fibroblasts obtained from control subjects and patients with emphysema.
Experimental lung research 2003;29(5):291-302.
2003: André Zandvoort; Monique E Lodewijk; Pieter A Klok; Wim Timens
Effects of multidose combination chemotherapy on the humoral immune system.
Clinical immunology (Orlando, Fla.) 2003;107(1):20-9.
2003: Eelco Fokkema; E G E de Vries; Harry J M Groen; Coby Meijer; Wim Timens
Expression of apoptosis-related proteins and morphological changes in a rat tumor model of human small cell lung cancer prior to and after treatment with radiotherapy, carboplatin, or combined treatment.
Virchows Archiv : an international journal of pathology 2003;442(4):349-55.
2003: P A M de Vries; A K L Oei-Reyners; A V M Möller; Wim Timens; J E Tulleken; T S van der Werf
[Fulminant pneumococcal sepsis in two splenectomized patients].
Nederlands tijdschrift voor geneeskunde 2003;147(10):450-4.
2003: Erik A M Verschuuren; Wim van Der Bij; Wim de Boer; Wim Timens; Jaap Middeldorp; T Hauw The
Quantitative Epstein-Barr virus (EBV) serology in lung transplant recipients with primary EBV infection and/or post-transplant lymphoproliferative disease.
Journal of medical virology 2003;69(2):258-66.
2003: André Zandvoort; Monique E Lodewijk; Pieter A Klok; Mijke A Breukels; Ger T Rijkers; Wim Timens
After chemotherapy, functional humoral response capacity is restored before complete restoration of lymphoid compartments.
Clinical and experimental immunology 2003;131(1):8-16.
2003: Nick H T Ten Hacken; Dirkje S Postma; Wim Timens
Airway remodeling and long-term decline in lung function in asthma.
Current opinion in pulmonary medicine 2003;9(1):9-14.
2002: Eelco Fokkema; Harry J M Groen; Coby Meijer; Wim Timens; Steven de Jong; Elisabeth G E de Vries
The role of apoptosis-related genes in non-small-cell lung cancer.
Clinical lung cancer 2002;4(3):174-82.
2002: André Zandvoort; Wim Timens
The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens.
Clinical and experimental immunology 2002;130(1):4-11.
2002: Machteld N Hylkema; Maarten O Hoekstra; Marjan A Luinge; Wim Timens
The strength of the OVA-induced airway inflammation in rats is strain dependent.
Clinical and experimental immunology 2002;129(3):390-6.
2002: Machteld N Hylkema; Wim Timens; Marjan A Luinge; Nienke Van Der Werf; Maarten O Hoekstra
The effect of bacillus Calmette-Guérin immunization depends on the genetic predisposition to Th2-type responsiveness.
American journal of respiratory cell and molecular biology 2002;27(2):244-9.
2002: George L Scheffer; Adriana C L M Pijnenborg; E F Smit; Michael Müller; D S Postma; Wim Timens; Paul Van Der Valk; E G E de Vries; Rik J Scheper
Multidrug resistance related molecules in human and murine lung.
Journal of clinical pathology 2002;55(5):332-9.
2002: Monique A Stokman; F K L Spijkervet; A N Machteld Wymenga; Fred R Burlage; Wim Timens; J L N Roodenburg; E G E de Vries
Quantification of oral mucositis due to radiotherapy by determining viability and maturation of epithelial cells.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2002;31(3):153-7.
2002: GJ Toes; K W van Muiswinkel; Wim van Oeveren; Albert J H Suurmeijer; Wim Timens; Ietse Stokroos; Jan J A M van den Dungen
Superhydrophobic modification fails to improve the performance of small diameter expanded polytetrafluoroethylene vascular grafts.
Biomaterials 2002;23(1):255-62.
2001: Mijke A Breukels; André Zandvoort; Germie van den Dobbelsteen; A van Den Muijsenberg; Monique E Lodewijk; Michel Beurret; Pieter A Klok; Wim Timens; Ger T Rijkers
Pneumococcal conjugate vaccines overcome splenic dependency of antibody response to pneumococcal polysaccharides.
Infection and immunity 2001;69(12):7583-7.
2001: HG Kreeftenberg; Jack J M Ligtenberg; Tjip S van der Werf; Wim Timens; J W Cohen Tervaert
Pulmonary vasculitis may obscure large cell lung carcinoma. A case report.
Clinical and experimental rheumatology 2001;19(6):731-4.
2001: André Zandvoort; Monique E Lodewijk; Nynke K de Boer; Peter M Dammers; Frans G M Kroese; Wim Timens
CD27 expression in the human splenic marginal zone: the infant marginal zone is populated by naive B cells.
Tissue antigens 2001;58(4):234-42.
2001: Fiona J Westerhof; Wim Timens; A van Oosten; Annet B Zuidhof; N Nauta; M Schuiling; J T W M Vos; Johan Zaagsma; Herman Meurs; wilko coers
Inflammatory cell distribution in guinea pig airways and its relationship to airway reactivity.
Mediators of inflammation 2001;10(3):143-54.
2001: Frank B Niessen; MP Andriessen; Joost Schalkwijk; Lydia Visser; Wim Timens
Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars.
The Journal of pathology 2001;194(2):207-16.
2001: André Zandvoort; Monique E Lodewijk; Pieter A Klok; Peter M Dammers; Frans G M Kroese; Wim Timens
Slow recovery of follicular B cells and marginal zone B cells after chemotherapy: implications for humoral immunity.
Clinical and experimental immunology 2001;124(2):172-9.
2001: N van der Laan; L F de Leij; W Buurman; Wim Timens; Henk Jan ten Duis
Tumor necrosis factor alpha (TNFalpha) in human skin: a comparison of different antibodies for immunohistochemistry.
Archives of dermatological research 2001;293(5):226-32.
2001: SR Rutgers; Wim Timens; Henk Kauffman; Dirkje S Postma
Markers of active airway inflammation and remodelling in chronic obstructive pulmonary disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(2):193-205.
2000: Janny Scholma; Dirk-Jan Slebos; H Marike Boezen; J W K van den Berg; Wim van Der Bij; Wim J de Boer; Gerard H Koëter; Wim Timens; Henk Kauffman; Dirkje S Postma
Eosinophilic granulocytes and interleukin-6 level in bronchoalveolar lavage fluid are associated with the development of obliterative bronchiolitis after lung transplantation.
American journal of respiratory and critical care medicine 2000;162(6):2221-5.
2000: Wim Timens
CD21.
Journal of biological regulators and homeostatic agents 2000;14(4):292-4.
2000: Nick H T Ten Hacken; Dirkje S Postma; G Drok; mocan dksok serega; J Kraan; Wim Timens
Increased vascular expression of iNOS at day but not at night in asthmatic subjects with increased nocturnal airway obstruction.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;16(3):445-51.
2000: SR Rutgers; Wim Timens; N Tzanakis; Henk Kauffman; Thomas W van der Mark; Gerard H Koëter; Dirkje S Postma
Airway inflammation and hyperresponsiveness to adenosine 5'-monophosphate in chronic obstructive pulmonary disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(5):657-62.
2000: Jan Paul Ouwens; H Haaxma-Reiche; Erik A M Verschuuren; Wim Timens; L H Steenhuis; Wim J de Boer; Wim van Der Bij
Visual symptoms after lung transplantation: a case of progressive multifocal leukoencephalopathy.
Transplant infectious disease : an official journal of the Transplantation Society 2000;2(1):29-32.
2000: SR Rutgers; Wim Timens; H F Kaufmann; Thomas W van der Mark; Gerard H Koëter; Dirkje S Postma
Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;15(1):109-15.
2000: SR Rutgers; Dirkje S Postma; Nick H T Ten Hacken; Henk Kauffman; Thomas W van der Mark; Gerard H Koëter; Wim Timens
Ongoing airway inflammation in patients with COPD who do not currently smoke.
Thorax 2000;55(1):12-8.
1999: Nick H T Ten Hacken; D S Postma; Wim Timens
Are asthma and chronic obstructive pulmonary disease different diseases?--Con.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 1999;54(6):551-8.
1999: J W K van den Berg; Wim van Der Bij; Wim J de Boer; D S Postma; Wim Timens; Gerard H Koëter
[Survival and impact of bronchiolitis obliterans syndrome after lung transplantation at the Academic Hospital Groningen, 1990/'98].
Nederlands tijdschrift voor geneeskunde 1999;143(44):2196-201.
1999: Wim J de Boer; D M Mehta; Wim Timens; H J Hoekstra
The short and long term effects of intraoperative electron beam radiotherapy (IORT) on thoracic organs after pneumonectomy an experimental study in the canine model.
International journal of radiation oncology, biology, physics 1999;45(2):501-6.
1999: R Leemans; G Harms; G T Rijkers; Wim Timens
Spleen autotransplantation provides restoration of functional splenic lymphoid compartments and improves the humoral immune response to pneumococcal polysaccharide vaccine.
Clinical and experimental immunology 1999;117(3):596-604.
1999: F Ismaël; T S van der Werf; Wim J de Boer; Wim Timens; G D Nossent; Jack J M Ligtenberg
[Primary sarcoma of A. pulmonalis: a rare cause of cor pulmonale].
Nederlands tijdschrift voor geneeskunde 1999;143(33):1705-9.
1999: Nick H T Ten Hacken; Wim Timens; Thomas W van der Mark; F P Nijkamp; D S Postma; G Folkerts
[Nitric oxide and asthma].
Nederlands tijdschrift voor geneeskunde 1999;143(31):1606-11.
1999: Jeannette F M van Straaten; wilko coers; Jacobien A Noordhoek; Sippie Huitema; Hans Flipsen; Henk Kauffman; Wim Timens; Dirkje S Postma
Proteoglycan changes in the extracellular matrix of lung tissue from patients with pulmonary emphysema.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1999;12(7):697-705.
1999: Désirée F Jansen; Jan Schouten; Judith M Vonk; Bert Rijcken; Wim Timens; J Kraan; Scott Weiss; Dirkje S Postma
Smoking and airway hyperresponsiveness especially in the presence of blood eosinophilia increase the risk to develop respiratory symptoms: a 25-year follow-up study in the general adult population.
American journal of respiratory and critical care medicine 1999;160(1):259-64.
1999: SR Rutgers; Thomas W van der Mark; wilko coers; Han Moshage; Wim Timens; Henk Kauffman; Gerard H Koëter; Dirkje S Postma
Markers of nitric oxide metabolism in sputum and exhaled air are not increased in chronic obstructive pulmonary disease.
Thorax 1999;54(7):576-80.
1999: A N Machteld Wymenga; Winette T A van der Graaf; L S Hofstra; F K L Spijkervet; Wim Timens; Hetty Timmer-Bosscha; Wim J Sluiter; A H van Buuren; Nanno H Mulder; Elisabeth G E de Vries
Phase I study of transforming growth factor-beta3 mouthwashes for prevention of chemotherapy-induced mucositis.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1363-8.
1999: Désirée F Jansen; Bert Rijcken; Jan Schouten; J Kraan; Scott Weiss; Wim Timens; Dirkje S Postma
The relationship of skin test positivity, high serum total IgE levels, and peripheral blood eosinophilia to symptomatic and asymptomatic airway hyperresponsiveness.
American journal of respiratory and critical care medicine 1999;159(3):924-31.
1999: wilko coers; Wim van Der Bij; G Drok; Wim Timens
Extracellular matrix composition of obliterated bronchioli in lung transplant recipients.
Transplantation proceedings 1999;31(1-2):191-2.
1999: R Leemans; W Manson; J A Snijder; J W Smit; HJ Klasen; T H The; Wim Timens
Immune response capacity after human splenic autotransplantation: restoration of response to individual pneumococcal vaccine subtypes.
Annals of surgery 1999;229(2):279-85.
1998: Nick H T Ten Hacken; Dirkje S Postma; F Bosma; G Drok; Bea Rutgers; J Kraan; Wim Timens
Vascular adhesion molecules in nocturnal asthma: a possible role for VCAM-1 in ongoing airway wall inflammation.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(12):1518-25.
1998: wilko coers; Wim Timens; C Kempinga; Pieter A Klok; Han Moshage
Specificity of antibodies to nitric oxide synthase isoforms in human, guinea pig, rat, and mouse tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(12):1385-92.
1998: Nick H T Ten Hacken; Wim Timens; mocan dksok serega; G Drok; J Kraan; Dirkje S Postma
Increased peak expiratory flow variation in asthma: severe persistent increase but not nocturnal worsening of airway inflammation.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;12(3):546-50.
1998: Jeannette F M van Straaten; Dirkje S Postma; wilko coers; Jacobien A Noordhoek; Henk Kauffman; Wim Timens
Macrophages in lung tissue from patients with pulmonary emphysema express both inducible and endothelial nitric oxide synthase.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1998;11(7):648-55.
1998: GJ Toes; Peter P van Geel; Jan J A M van den Dungen; Hendrik Buikema; J G Grandjean; Eric L G Verhoeven; Wim van Oeveren; Wim Timens
The use of the gastroepiploic artery for peripheral revascularisation. A study in pigs.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 1998;15(4):320-6.
1998: Marina Saetta; P K Jeffery; Piero Maestrelli; Wim Timens
Biopsies: processing and assessment.
The European respiratory journal. Supplement 1998;26():20S-25S.
1998: Nick H T Ten Hacken; RM Aleva; Y Oosterhoff; mocan dksok serega; J Kraan; Dirkje S Postma; Wim Timens
Submucosa 1.0 x 0.1 mm in size is sufficient to count inflammatory cell numbers in human airway biopsy specimens.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1998;11(3):292-4.
1998: LV Möller; Wim Timens; W van der Bij; K Kooi; Bob De Wever; Jacob Dankert; Loek van Alphen
Haemophilus influenzae in lung explants of patients with end-stage pulmonary disease.
American journal of respiratory and critical care medicine 1998;157(3 Pt 1):950-6.
1998: R C van Waardenburg; Chris J L M Meijer; S J Pinto-Sietsma; Elisabeth G E de Vries; Wim Timens; N M Mulder
Effects of c-myc oncogene modulation on differentiation of human small cell lung carcinoma cell lines.
Anticancer research 1998;18(1A):91-5.
1998: RM Aleva; J Kraan; mocan dksok serega; Nick H T Ten Hacken; Dirkje S Postma; Wim Timens
Techniques in human airway inflammation: quantity and morphology of bronchial biopsy specimens taken by forceps of three sizes.
Chest 1998;113(1):182-5.
1997: Wim Timens; Willem A Kamps
Hemopoiesis in human fetal and embryonic liver.
Microscopy research and technique 1997;39(5):387-97.
1997: Nick H T Ten Hacken; RM Aleva; Bea Rutgers; J Kraan; H van Goor; Dirkje S Postma; Wim Timens
Techniques in human airway inflammation: differences in plastic-embedded and snap-frozen sections for CD3, CD4, and CD8 immunostaining of bronchial biopsy specimens.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1997;10(10):1043-6.
1997: Désirée F Jansen; Wim Timens; J Kraan; Bert Rijcken; Dirkje S Postma
(A)symptomatic bronchial hyper-responsiveness and asthma.
Respiratory medicine 1997;91(3):121-34.
1997: A N Machteld Wymenga; Winette T A van der Graaf; F L Spijkervet; Wim Timens; Hetty Timmer-Bosscha; Wim J Sluiter; Elisabeth G E de Vries; Nanno H Mulder
A new in vitro assay for quantitation of chemotherapy-induced mucositis.
British journal of cancer 1997;76(8):1062-6.
1996: J H de Graaf; R Y Tamminga; A Dam-Meiring; Willem A Kamps; Wim Timens
The presence of cytokines in Langerhans' cell histiocytosis.
The Journal of pathology 1996;180(4):400-6.
1996: J de Boer; Herman Meurs; wilko coers; M Koopal; A E Bottone; A C Visser; Wim Timens; Johan Zaagsma
Deficiency of nitric oxide in allergen-induced airway hyperreactivity to contractile agonists after the early asthmatic reaction: an ex vivo study.
British journal of pharmacology 1996;119(6):1109-16.
1996: G Harms; M J Hardonk; Wim Timens
In vitro complement-dependent binding and in vivo kinetics of pneumococcal polysaccharide TI-2 antigens in the rat spleen marginal zone and follicle.
Infection and immunity 1996;64(10):4220-5.
1996: W G Horstmann; Wim Timens
Lack of adhesion molecules in testicular diffuse centroblastic and immunoblastic B cell lymphomas as a contributory factor in malignant behaviour.
Virchows Archiv : an international journal of pathology 1996;429(2-3):83-90.
1996: R Leemans; H Beekhuis; Wim Timens; T Hauw The; H J Klasen
Fc-receptor function after human splenic autotransplantation.
The British journal of surgery 1996;83(4):543-6.
1996: M J Peset Llopis; G Harms; M J Hardonk; Wim Timens
Human immune response to pneumococcal polysaccharides: complement-mediated localization preferentially on CD21-positive splenic marginal zone B cells and follicular dendritic cells.
The Journal of allergy and clinical immunology 1996;97(4):1015-24.
1995: Y Oosterhoff; Wim Timens; Dirkje S Postma
The role of airway inflammation in the pathophysiology of nocturnal asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(10):915-21.
1995: J H de Graaf; R Y Tamminga; Willem A Kamps; Wim Timens
Expression of cellular adhesion molecules in Langerhans cell histiocytosis and normal Langerhans cells.
The American journal of pathology 1995;147(4):1161-71.
1995: Wim Timens
Cell adhesion molecule expression and homing of hematologic malignancies.
Critical reviews in oncology/hematology 1995;19(2):111-29.
1995: J H de Graaf; G P Mannes; R Y Tamminga; Willem A Kamps; Wim Timens
The role of cytokines in the pathogenesis of pulmonary Langerhans' cell histiocytosis.
Advances in experimental medicine and biology 1995;378():535-7.
1995: A C Lambrechts; Leendert H J Looijenga; Mars B van't Veer; Jannie van Echten; Wim Timens; J Wolter Oosterhuis
Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study.
British journal of cancer 1995;71(1):73-7.
1994: Harald J Hoekstra; R Y Tamminga; Wim Timens
Partial splenectomy in children: an alternative for splenectomy in the pathological staging of Hodgkin's disease.
Annals of surgical oncology 1994;1(6):480-6.
1994: G P Mannes; Wim J de Boer; Wim van Der Bij; Gerard H Koëter; JJ Meuzelaar; Wim Timens
[Lung transplantation: sometimes a solution in pulmonary fibrosis].
Nederlands tijdschrift voor geneeskunde 1994;138(43):2129-33.
1994: T S van der Werf; Coen A Stegeman; K J Meuzelaar; Wim Timens
Late recurrence of Wegener's granulomatosis presenting as solitary upper lobe pulmonary mass.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(7):1365-8.
1994: A Timmer; J W Oosterhuis; HS Schraffordt Koops; Dirk T Sleijfer; B G Szabo; Wim Timens
The tumor microenvironment: possible role of integrins and the extracellular matrix in tumor biological behavior of intratubular germ cell neoplasia and testicular seminomas.
The American journal of pathology 1994;144(5):1035-44.
1994: J H de Graaf; R Y Tamminga; Willem A Kamps; Wim Timens
Langerhans' cell histiocytosis: expression of leukocyte cellular adhesion molecules suggests abnormal homing and differentiation.
The American journal of pathology 1994;144(3):466-72.
1994: H van Kamp; E van den Berg; Wim Timens; R A Kraaijenbrink; M R Halie; S M G J Daenen
Sweet's syndrome in myeloid malignancy: a report of two cases.
British journal of haematology 1994;86(2):415-7.
1994: Egbert F Smit; H J Groen; Wim Timens; Wim J de Boer; Pieter E Postmus
Surgical resection for small cell carcinoma of the lung: a retrospective study.
Thorax 1994;49(1):20-2.
1994: J Peringa; W M Molenaar; Wim Timens
Integrins and extracellular matrix-proteins in the different components of the Wilms' tumour.
Virchows Archiv : an international journal of pathology 1994;425(2):113-9.
1993: Harald J Hoekstra; R Y Tamminga; Wim Timens
[Partial instead of complete splenectomy in children for the pathological staging of Hodgkin disease].
Nederlands tijdschrift voor geneeskunde 1993;137(48):2491-4.
1993: Jan G R de Monchy; René Aalbers; Wim Timens
The clinical relevance of bronchial biopsies in asthma.
Respiratory medicine 1993;87 Suppl B():23-4.
1993: René Aalbers; M Smith; Wim Timens
Immunohistology in bronchial asthma.
Respiratory medicine 1993;87 Suppl B():13-21.
1993: René Aalbers; Jan G R de Monchy; Henk Kauffman; M Smith; Y Hoekstra; Bart Vrugt; Wim Timens
Dynamics of eosinophil infiltration in the bronchial mucosa before and after the late asthmatic reaction.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(6):840-7.
1993: René Aalbers; Henk Kauffman; Bart Vrugt; M Smith; Gerard H Koëter; Wim Timens; Jan G R de Monchy
Bronchial lavage and bronchoalveolar lavage in allergen-induced single early and dual asthmatic responders.
The American review of respiratory disease 1993;147(1):76-81.
1993: C Thomas; A M Nijenhuis; Wim Timens; Peter Kuppen; Toos Daemen; Gerrit L Scherphof
Liver metastasis model of colon cancer in the rat: immunohistochemical characterization.
Invasion & metastasis 1993;13(2):102-12.
1992: E J Kuipers; Wim Timens; S M G J Daenen
Kikuchi-Fujimoto disease complicated by severe rhabdomyolysis.
Annals of hematology 1992;65(6):278-80.
1992: J H de Graaf; Wim Timens; R Y Tamminga; W M Molenaar
Deep juvenile xanthogranuloma: a lesion related to dermal indeterminate cells.
Human pathology 1992;23(8):905-10.
1992: Wim Timens; R Leemans
Splenic autotransplantation and the immune system. Adequate testing required for evaluation of effect.
Annals of surgery 1992;215(3):256-60.
1992: R Y Tamminga; Wim Timens; Willem A Kamps
[The hazard of asplenia: a fulminant sepsis].
Nederlands tijdschrift voor geneeskunde 1992;136(6):257-9.
1991: J Wolter Oosterhuis; Eva van den Berg; Bauke de Jong; Wim Timens; S M Castedo; R H Rammeloo; Dirk T Sleijfer
Mediastinal germ cell tumor with secondary nongerm cell malignancy, and extensive hematopoietic activity. Pathology, DNA-ploidy, and karyotyping.
Cancer genetics and cytogenetics 1991;54(2):183-95.
1991: Wim Timens
The human spleen and the immune system: not just another lymphoid organ.
Research in immunology 1991;142(4):316-20.
1991: Wim Timens; A Boes; H Vos; S Poppema
Tissue distribution of the C3d/EBV-receptor: CD21 monoclonal antibodies reactive with a variety of epithelial cells, medullary thymocytes, and peripheral T-cells.
Histochemistry 1991;95(6):605-11.
1990: F G Kroese; Wim Timens; P Nieuwenhuis
Germinal center reaction and B lymphocytes: morphology and function.
Current topics in pathology. Ergebnisse der Pathologie 1990;84 ( Pt 1)():103-48.
1990: Wim Timens; Willem A Kamps; T Rozeboom-Uiterwijk; S Poppema
Haemopoiesis in human fetal and embryonic liver. Immunohistochemical determination in B5-fixed paraffin-embedded tissues.
Virchows Archiv. A, Pathological anatomy and histopathology 1990;416(5):429-36.
1989: Wim Timens; A Boes; T Rozeboom-Uiterwijk; S Poppema
Immaturity of the human splenic marginal zone in infancy. Possible contribution to the deficient infant immune response.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3200-6.
1989: Wim Timens; A Boes; S Poppema
Human marginal zone B cells are not an activated B cell subset: strong expression of CD21 as a putative mediator for rapid B cell activation.
European journal of immunology 1989;19(11):2163-6.
1989: Willem A Kamps; Wim Timens; G J De Boer; H H Spanjer; S Poppema
In situ study of haemopoiesis in human fetal liver.
Scandinavian journal of immunology 1989;30(4):399-408.
1989: J Westerga; Wim Timens
Immunohistological analysis of human fetal lymph nodes.
Scandinavian journal of immunology 1989;29(1):103-12.
1989: S Poppema; L Visser; B de Jong; M Brinker; J Atmosoerodjo; Wim Timens
The typical Reed-Sternberg phenotype and Ig gene rearrangement of Hodgkin's disease derived cell line ZO indicating a B-cell origin.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1989;117():67-74.
1988: Wim Timens; A Boes; T Rozeboom-Uiterwijk; S Poppema
Immuno-architecture of human fetal lymphoid tissues.
Virchows Archiv. A, Pathological anatomy and histopathology 1988;413(6):563-71.
1987: Willem A Kamps; Wim Timens; G J de Boer; T Rozeboom-Uiterwijk; H H Spanjer; S Poppema
Study of haemopoiesis in the human embryonal and foetal liver.
Annales de l'Institut Pasteur. Immunology 1987;138(6):869-76.
1987: M G Brinker; S Poppema; C H Buys; Wim Timens; J Osinga; L Visser
Clonal immunoglobulin gene rearrangements in tissues involved by Hodgkin's disease.
Blood 1987;70(1):186-91.
1987: Wim Timens; T Rozeboom; S Poppema
Fetal and neonatal development of human spleen: an immunohistological study.
Immunology 1987;60(4):603-9.
1986: Wim Timens; L Visser; S Poppema
Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma.
Laboratory investigation; a journal of technical methods and pathology 1986;54(4):457-61.
1985: Wim Timens; S Poppema
Lymphocyte compartments in human spleen. An immunohistologic study in normal spleens and uninvolved spleens in Hodgkin's disease.
The American journal of pathology 1985;120(3):443-54.
1985: S Poppema; A Boes; L de Ley; T Rozeboom; Wim Timens; E Schwander; L Visser
Double immunoenzymatic staining employing rat and mouse monoclonal antibodies.
Advances in experimental medicine and biology 1985;186():767-75.
1985: S Poppema; Wim Timens; L Visser
Nodular lymphocyte predominance type of Hodgkin's disease is a B cell lymphoma.
Advances in experimental medicine and biology 1985;186():963-9.
1982: Wim Timens; J Koudstaal; S Poppema
Morphometrical analysis of T- and B-cell compartments of spleens in Hodgkin's disease.
Virchows Archiv. B, Cell pathology including molecular pathology 1982;38(3):291-6.