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Koichi Fukase

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Yukari Fujimoto; Chika Kasamatsu; Naohiro Kitayama; Akinori Saeki; Atsushi Shimoyama; Hiroko Tsutsui; Koichi Fukase
Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses.
Takayuki Iwata; Satoshi Nozaki; Hirotaka Onoe; Tsuyoshi Tahara; Katsunori Tanaka; Yasuyoshi Watanabe; Koichi Fukase
A conformationally fixed analog of the peptide mimic Grb2-SH2 domain: synthesis and evaluation against the A431 cancer cell.
Ning Wang; Yukari Fujimoto; Mizuho Hasegawa; Cheng-Yuan Huang; Naohiro Inohara; Koichi Fukase
Glycan sequence-dependent Nod2 activation investigated by using a chemically synthesized bacterial peptidoglycan fragment library.

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2013: Yukari Fujimoto; Chika Kasamatsu; Naohiro Kitayama; Akinori Saeki; Atsushi Shimoyama; Hiroko Tsutsui; Koichi Fukase
Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses.
Molecular bioSystems 2013;9(5):987-96.
2013: Takayuki Iwata; Satoshi Nozaki; Hirotaka Onoe; Tsuyoshi Tahara; Katsunori Tanaka; Yasuyoshi Watanabe; Koichi Fukase
A conformationally fixed analog of the peptide mimic Grb2-SH2 domain: synthesis and evaluation against the A431 cancer cell.
Molecular bioSystems 2013;9(5):1019-25.
2013: Ning Wang; Yukari Fujimoto; Mizuho Hasegawa; Cheng-Yuan Huang; Naohiro Inohara; Koichi Fukase
Glycan sequence-dependent Nod2 activation investigated by using a chemically synthesized bacterial peptidoglycan fragment library.
Chembiochem : a European journal of chemical biology 2013;14(4):482-8.
2013: Katsunori Tanaka; Satomi Yokoi; Koichi Koyama; Eiji Miyoshi; Kenta Moriwaki; Koichi Fukase
Whole-body imaging of tumor cells by azaelectrocyclization: visualization of metastasis dependence on glycan structure.
Bioorganic & medicinal chemistry 2013;21(5):1074-7.
2013: Takanori Iwasaki; Hitoshi Kuniyasu; Vutukuri P Reddy; Jun Terao; Yukari Fujimoto; Koichi Fukase; Kiyokazu Higashikawa; Willbe W S Ho; Nobuaki Kambe
Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl Grignard reagents: a practical and versatile method for preparing fatty acids.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013;19(9):2956-60.
2012: Koichi Fukase; Katsunori Tanaka
Bio-imaging and cancer targeting with glycoproteins and N-glycans.
Current opinion in chemical biology 2012;16(5-6):614-21.
2012: Yukari Fujimoto; Atsushi Shimoyama; Yasuo Suda; Koichi Fukase
Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A.
Carbohydrate research 2012;356():37-43.
2012: Umeharu Ohto; Koichi Fukase; Kensuke Miyake; Toshiyuki Shimizu
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7421-6.
2012: Yukari Fujimoto; Naohiro Inohara; Ambara Rachmat Pradipta; Koichi Fukase
Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation.
Natural product reports 2012;29(5):568-79.
2012: Katsunori Tanaka; Yasuyoshi Watanabe; Shunsuke Douke; Takayuki Iwata; Chika Kageyama; Nobutoshi Murakami; Satoshi Nozaki; Hirotaka Onoe; Sanae Shirotsuki; Eric R O Siwu; Tsuyoshi Tahara; Satoru Tamura; Koichi Fukase
Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain.
ACS chemical biology 2012;7(4):637-45.
2012: Katsunori Tanaka; Satomi Yokoi; Takeshi Fujiwara; Takayuki Iwata; Koichi Koyama; Koji Morimoto; Yuka Nakamoto; Kaori Nakayama; Koichi Fukase
Cell surface biotinylation by azaelectrocyclization: easy-handling and versatile approach for living cell labeling.
Bioorganic & medicinal chemistry 2012;20(6):1865-8.
2012: Yasuo Suda; Fumiaki Okazaki; Seiji Adachi; Koichi Fukase; Yushi Hasegawa; Susumu Kokubo; Seiki Kuramitsu; Shoichi Kusumoto
Structural characterization of neutral and acidic glycolipids from Thermus thermophilus HB8.
PloS one 2012;7(7):e35067.
2011: Yosuke Uchinashi; Jiazhou Zhou; Masahiro Nagasaki; Katsunori Tanaka; Koichi Fukase
Reinvestigation of the C5-acetamide sialic acid donor for α-selective sialylation: practical procedure under microfluidic conditions.
Organic & biomolecular chemistry 2011;9(20):7243-8.
2011: Ryoko Sawahata; Hiroaki Shime; Sayuri Yamazaki; Norimitsu Inoue; Takashi Akazawa; Yukari Fujimoto; Koichi Fukase; Misako Matsumoto; Tsukasa Seya
Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2.
Microbes and infection / Institut Pasteur 2011;13(4):350-8.
2011: Yukari Fujimoto; Koichi Fukase
Structures, synthesis, and human Nod1 stimulation of immunostimulatory bacterial peptidoglycan fragments in the environment.
Journal of natural products 2011;74(3):518-25.
2010: Katsunori Tanaka; Eric R O Siwu; Kaori Minami; Koki Hasegawa; Satoshi Nozaki; Yousuke Kanayama; Koichi Koyama; Weihsu C Chen; James C Paulson; Yasuyoshi Watanabe; Koichi Fukase
Noninvasive imaging of dendrimer-type N-glycan clusters: in vivo dynamics dependence on oligosaccharide structure.
Angewandte Chemie (International ed. in English) 2010;49(44):8195-200.
2010: Ambara R Pradipta; Yukari Fujimoto; Mizuho Hasegawa; Naohiro Inohara; Koichi Fukase
Characterization of natural human nucleotide-binding oligomerization domain protein 1 (Nod1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment.
The Journal of biological chemistry 2010;285(31):23607-13.
2010: Katsunori Tanaka; Kaori Minami; Tsuyoshi Tahara; Yohei Fujii; Eric R O Siwu; Satoshi Nozaki; Hirotaka Onoe; Satomi Yokoi; Koichi Koyama; Yasuyoshi Watanabe; Koichi Fukase
Electrocyclization-based labeling allows efficient in vivo imaging of cellular trafficking.
ChemMedChem 2010;5(6):841-5.
2010: Guang-ming Bao; Katsunori Tanaka; Kazuhiro Ikenaka; Koichi Fukase
Probe design and synthesis of Galbeta(1-->3)[NeuAcalpha(2-->6)]GlcNAcbeta(1-->2)Man motif of N-glycan.
Bioorganic & medicinal chemistry 2010;18(11):3760-6.
2010: Thomas Gutsmann; Jörg Howe; Ulrich Zähringer; Patrick Garidel; Andra B Schromm; M H J Koch; Y Fujimoto; Koichi Fukase; I Moriyon; G Martínez-de-Tejada; Klaus Brandenburg
Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells.
Innate immunity 2010;16(1):39-47.
2010: Masahiro Azuma; Ryoko Sawahata; Yuusuke Akao; Takashi Ebihara; Sayuri Yamazaki; Misako Matsumoto; Masahito Hashimoto; Koichi Fukase; Yukari Fujimoto; Tsukasa Seya
The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation.
PloS one 2010;5(9):.
2009: Taku Sakaguchi; Toyoharu Kobayashi; Sho Hatano; Hiroshi Tsuchikawa; Koichi Fukase; Katsunori Tanaka; Shigeo Katsumura
Library-directed solution- and solid-phase synthesis of 2,4-disubstituted pyridines: one-pot approach through 6pi-azaelectrocyclization.
Chemistry, an Asian journal 2009;4(10):1573-7.
2009: Yukari Fujimoto; Masahito Hashimoto; Maiko Furuyashiki; Mami Katsumoto; Tsukasa Seya; Yasuo Suda; Koichi Fukase
Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: prediction with mrna expression, chemical synthesis, and immunostimulatory activities.
Chembiochem : a European journal of chemical biology 2009;10(14):2311-5.
2009: Uwe Mamat; Helgo Schmidt; Eva Munoz; Buko Lindner; Koichi Fukase; Anna Hanuszkiewicz; Jing Wu; Timothy C Meredith; Ronald W Woodard; Rolf Hilgenfeld; Jeroen R Mesters; Otto Holst
WaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis.
The Journal of biological chemistry 2009;284(33):22248-62.
2009: Katsunori Tanaka; Yohei Fujii; Hiroomi Tokimoto; Yasutaka Mori; Shin-ichi Tanaka; Guang-ming Bao; Eric R O Siwu; Aiko Nakayabu; Koichi Fukase
Synthesis of a sialic acid containing complex-type N-glycan on a solid support.
Chemistry, an Asian journal 2009;4(4):574-80.
2009: Kazuki Tawaratsumida; Maiko Furuyashiki; Mami Katsumoto; Yukari Fujimoto; Koichi Fukase; Yasuo Suda; Masahito Hashimoto
Characterization of N-terminal structure of TLR2-activating lipoprotein in Staphylococcus aureus.
The Journal of biological chemistry 2009;284(14):9147-52.
2009: Katsunori Tanaka; Koichi Fukase
Acid-mediated reactions under microfluidic conditions: a new strategy for practical synthesis of biofunctional natural products.
Beilstein journal of organic chemistry 2009;5():40.
2008: Katsunori Tanaka; Yohei Fujii; Koichi Fukase
Site-selective and nondestructive protein labeling through azaelectrocyclization-induced cascade reactions.
Chembiochem : a European journal of chemical biology 2008;9(15):2392-7.
2008: Yun-Gi Kim; Jong-Hwan Park; Stephanie Daignault; Koichi Fukase; Gabriel Núñez
Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):4340-6.
2008: Tamaki Yano; Shizuka Mita; Hiroko Ohmori; Yoshiteru Oshima; Yukari Fujimoto; Ryu Ueda; Haruhiko Takada; William Goldman; Koichi Fukase; Neal Silverman; Tamotsu Yoshimori; Shoichiro Kurata
Autophagic control of listeria through intracellular innate immune recognition in drosophila.
Nature immunology 2008;9(8):908-16.
2008: Katsunori Tanaka; Koichi Fukase
PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics.
Organic & biomolecular chemistry 2008;6(5):815-28.
2008: Masanori Tohno; Tomoyuki Shimazu; Hisashi Aso; Akiko Uehara; Haruhiko Takada; Akiko Kawasaki; Yukari Fujimoto; Koichi Fukase; Tadao Saito; Haruki Kitazawa
Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine.
Molecular immunology 2008;45(6):1807-17.
2008: Mizuho Hasegawa; Yukari Fujimoto; Peter C Lucas; Hiroyasu Nakano; Koichi Fukase; Gabriel Núñez; Naohiro Inohara
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.
The EMBO journal 2008;27(2):373-83.
2008: Prasad Rallabhandi; Agnes A Awomoyi; Karen E Thomas; Armelle Phalipon; Yukari Fujimoto; Koichi Fukase; Shoichi Kusumoto; Nilofer Qureshi; Marcelo B Sztein; Stefanie N Vogel
Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1139-47.
2008: Akiko Kawasaki; Yukie Karasudani; Yuji Otsuka; Mizuho Hasegawa; Naohiro Inohara; Yukari Fujimoto; Koichi Fukase
Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functions.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(33):10318-30.
2008: Katsunori Tanaka; Tatsuro Masuyama; Koki Hasegawa; Tsuyoshi Tahara; Hiroshi Mizuma; Yasuhiro Wada; Yasuyoshi Watanabe; Koichi Fukase
A submicrogram-scale protocol for biomolecule-based PET imaging by rapid 6pi-azaelectrocyclization: visualization of sialic acid dependent circulatory residence of glycoproteins.
Angewandte Chemie (International ed. in English) 2008;47(1):102-5.
2007: Jong-Hwan Park; Yun-Gi Kim; Michael Shaw; Thirumala-Devi Kanneganti; Yukari Fujimoto; Koichi Fukase; Naohiro Inohara; Gabriel Núñez
Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):514-21.
2007: Umeharu Ohto; Koichi Fukase; Kensuke Miyake; Yoshinori Satow
Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.
Science (New York, N.Y.) 2007;316(5831):1632-4.
2007: Akiko Uehara; Yukari Fujimoto; Koichi Fukase; Haruhiko Takada
Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines.
Molecular immunology 2007;44(12):3100-11.
2007: Mizuho Hasegawa; Akiko Kawasaki; Kangkang Yang; Yukari Fujimoto; Junya Masumoto; Eefjan Breukink; Gabriel Nuñez; Koichi Fukase; Naohiro Inohara
A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses.
The Journal of biological chemistry 2007;282(16):11757-64.
2007: Ling Zhao; Myung-Ja Kwon; Shurong Huang; Joo Y Lee; Koichi Fukase; Naohiro Inohara; Daniel H Hwang
Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells.
The Journal of biological chemistry 2007;282(16):11618-28.
2007: Masahito Hashimoto; Maiko Furuyashiki; Ryoko Kaseya; Yuka Fukada; Mai Akimaru; Kazue Aoyama; Toshiomi Okuno; Toshihide Tamura; Teruo Kirikae; Fumiko Kirikae; Nobutaka Eiraku; Hirofumi Morioka; Yukari Fujimoto; Koichi Fukase; Katsuhiro Takashige; Yoichiro Moriya; Shoichi Kusumoto; Yasuo Suda
Evidence of immunostimulating lipoprotein existing in the natural lipoteichoic acid fraction.
Infection and immunity 2007;75(4):1926-32.
2007: Masahiro Azuma; Aya Matsuo; Yukari Fujimoto; Koichi Fukase; Kaoru Hazeki; Osamu Hazeki; Misako Matsumoto; Tsukasa Seya
Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI).
Biochemical and biophysical research communications 2007;354(2):574-8.
2007: Katsunori Tanaka; Shinya Motomatsu; Koichi Koyama; Shin-ichi Tanaka; Koichi Fukase
Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step.
Organic letters 2007;9(2):299-302.
2007: Yukari Fujimoto; Seiichi Inamura; Akiko Kawasaki; Zenyu Shiokawa; Atsushi Shimoyama; Takashi Hashimoto; Shoichi Kusumoto; Koichi Fukase
Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism.
Journal of endotoxin research 2007;13(3):189-96.
2006: Hiroaki Mitsuzawa; Chiaki Nishitani; Naoki Hyakushima; Takeyuki Shimizu; Hitomi Sano; Norio Matsushima; Koichi Fukase; Yoshio Kuroki
Recombinant soluble forms of extracellular TLR4 domain and MD-2 inhibit lipopolysaccharide binding on cell surface and dampen lipopolysaccharide-induced pulmonary inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):8133-9.
2006: Kei Ono; Chiaki Nishitani; Hiroaki Mitsuzawa; Takeyuki Shimizu; Hitomi Sano; Hiroshi Suzuki; Tatsuhiko Kodama; Nobuhiro Fujii; Koichi Fukase; Koichi Hirata; Yoshio Kuroki
Mannose-binding lectin augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer cells through increased cell surface expression of scavenger receptor A.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5517-23.
2006: Sara W Montminy; Naseema Khan; Sara McGrath; Mitchell J Walkowicz; Fiona Sharp; Joseph E Conlon; Koichi Fukase; Shoichi Kusumoto; Charles Sweet; Kensuke Miyake; Shizuo Akira; Robert J Cotter; Jon Goguen; Egil Lien
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response.
Nature immunology 2006;7(10):1066-73.
2006: Masao Akamatsu; Yukari Fujimoto; Mikayo Kataoka; Yasuo Suda; Shoichi Kusumoto; Koichi Fukase
Synthesis of lipid A monosaccharide analogues containing acidic amino acid: exploring the structural basis for the endotoxic and antagonistic activities.
Bioorganic & medicinal chemistry 2006;14(19):6759-77.
2006: Mizuho Hasegawa; Kangkang Yang; Masahito Hashimoto; Jong-Hwan Park; Yun-Gi Kim; Yukari Fujimoto; Gabriel Nuñez; Koichi Fukase; Naohiro Inohara
Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.
The Journal of biological chemistry 2006;281(39):29054-63.
2006: Tsuyoshi Tanabe; Ikuo Ishige; Yoshimi Suzuki; Yukie Aita; Asuka Furukawa; Yuki Ishige; Keisuke Uchida; Takashige Suzuki; Tamiko Takemura; Soichiro Ikushima; Masaru Oritsu; Tetsuji Yokoyama; Yukari Fujimoto; Koichi Fukase; Naohiro Inohara; Gabriel Nunez; Yoshinobu Eishi
Sarcoidosis and NOD1 variation with impaired recognition of intracellular Propionibacterium acnes.
Biochimica et biophysica acta 2006;1762(9):794-801.
2006: Akiko Uehara; Yukari Fujimoto; Akiko Kawasaki; Shoichi Kusumoto; Koichi Fukase; Haruhiko Takada
Meso-diaminopimelic acid and meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD1.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1796-804.
2006: Y Sugawara; A Uehara; Y Fujimoto; S Kusumoto; Koichi Fukase; K Shibata; S Sugawara; T Sasano; H Takada
Toll-like receptors, NOD1, and NOD2 in oral epithelial cells.
Journal of dental research 2006;85(6):524-9.
2006: Makiko Kobayashi; Shin-ichiroh Saitoh; Natsuko Tanimura; Koichiro Takahashi; Kiyoshi Kawasaki; Masahiro Nishijima; Yukari Fujimoto; Koichi Fukase; Sachiko Akashi-Takamura; Kensuke Miyake
Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6211-8.
2006: Ji Won Park; Byung-Rok Je; Shunfu Piao; Seiichi Inamura; Yukari Fujimoto; Koichi Fukase; Shoichi Kusumoto; Kenneth Söderhäll; Nam-Chul Ha; Bok Luel Lee
A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade.
The Journal of biological chemistry 2006;281(12):7747-55.
2006: Sophie C Gangloff; Guy Ladam; Valérie Dupray; Koichi Fukase; Klaus Brandenburg; Moncef Guenounou; Pierre Schaaf; Jean-Claude Voegel; Nadia Benkirane-Jessel
Biologically active lipid A antagonist embedded in a multilayered polyelectrolyte architecture.
Biomaterials 2006;27(9):1771-7.
2006: Junya Masumoto; Kangkang Yang; Sooryanarayana Lnu; Mizuho Hasegawa; Scott A Tomlins; Su Qiu; Yukari Fujimoto; Akiko Kawasaki; Simon J Foster; Yasuo Horie; Tak W Mak; Gabriel Núñez; Arul M Chinnaiyan; Koichi Fukase; Naohiro Inohara
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo.
The Journal of experimental medicine 2006;203(1):203-13.
2006: Seiichi Inamura; Yukari Fujimoto; Akiko Kawasaki; Zenyu Shiokawa; Eva Woelk; Holger Heine; Buko Lindner; Naohiro Inohara; Shoichi Kusumoto; Koichi Fukase
Synthesis of peptidoglycan fragments and evaluation of their biological activity.
Organic & biomolecular chemistry 2006;4(2):232-42.
2006: Shoichi Kusumoto; Koichi Fukase
Synthesis of endotoxic principle of bacterial lipopolysaccharide and its recognition by the innate immune systems of hosts.
Chemical record (New York, N.Y.) 2006;6(6):333-43.
2005: Ju Hyun Cho; Iain P Fraser; Koichi Fukase; Shoichi Kusumoto; Yukari Fujimoto; Gregory L Stahl; R Alan B Ezekowitz
Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity.
Blood 2005;106(7):2551-8.
2005: Junji Uehori; Koichi Fukase; Takashi Akazawa; Satoshi Uematsu; Shizuo Akira; Kenji Funami; Masashi Shingai; Misako Matsumoto; Ichiro Azuma; Kumao Toyoshima; Shoichi Kusumoto; Tsukasa Seya
Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):7096-103.
2005: Akiko Uehara; Y Sugawara; S Kurata; Yukari Fujimoto; Koichi Fukase; Shoichi Kusumoto; Y Satta; T Sasano; Shunji Sugawara; Haruhiko Takada
Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells.
Cellular microbiology 2005;7(5):675-86.
2005: Yukari Fujimoto; Yo Adachi; Masao Akamatsu; Yoshiyuki Fukase; Mikayo Kataoka; Yasuo Suda; Koichi Fukase; Shoichi Kusumoto
Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity.
Journal of endotoxin research 2005;11(6):341-7.
2005: Ulrich Seydel; Andra B Schromm; Lore Brade; Sabine Gronow; Jörg Andrä; Mareike Müller; Michel H J Koch; Koichi Fukase; Mikayo Kataoka; Masaya Hashimoto; Shoichi Kusumoto; Klaus Brandenburg
Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity.
The FEBS journal 2005;272(2):327-40.
2005: Akiko Uehara; Shuhua Yang; Yukari Fujimoto; Koichi Fukase; Shoichi Kusumoto; K Shibata; Shunji Sugawara; Haruhiko Takada
Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture.
Cellular microbiology 2005;7(1):53-61.
2004: Masato Oikawa; Tetsuya Shintaku; Naohiro Fukuda; Harald Sekljic; Yoshiyuki Fukase; Hiroaki Yoshizaki; Koichi Fukase; Shoichi Kusumoto
NMR conformational analysis of biosynthetic precursor-type lipid A: monomolecular state and supramolecular assembly.
Organic & biomolecular chemistry 2004;2(24):3557-65.
2004: Martha Triantafilou; Klaus Brandenburg; Shoichi Kusumoto; Koichi Fukase; Alan Mackie; Ulrich Seydel; Kathy Triantafilou
Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses.
The Biochemical journal 2004;381(Pt 2):527-36.
2004: Shin-ichiroh Saitoh; Sachiko Akashi; Takenao Yamada; Natsuko Tanimura; Makiko Kobayashi; Kazunori Konno; Fumi Matsumoto; Koichi Fukase; Shoichi Kusumoto; Yoshinori Nagai; Yutaka Kusumoto; Atsushi Kosugi; Kensuke Miyake
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization.
International immunology 2004;16(7):961-9.
2004: Mareike Mueller; Buko Lindner; Shoichi Kusumoto; Koichi Fukase; Andra B Schromm; Ulrich Seydel
Aggregates are the biologically active units of endotoxin.
The Journal of biological chemistry 2004;279(25):26307-13.
2004: Takashi Kaneko; William Goldman; Peter Mellroth; Håkan Steiner; Koichi Fukase; Shoichi Kusumoto; William Harley; Alvin Fox; Douglas T Golenbock; Neal Silverman
Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway.
Immunity 2004;20(5):637-49.
2004: Shin-ichiroh Saitoh; Sachiko Akashi; Takenao Yamada; Natsuko Tanimura; Fumi Matsumoto; Koichi Fukase; Shoichi Kusumoto; Atsushi Kosugi; Kensuke Miyake
Ligand-dependent Toll-like receptor 4 (TLR4)-oligomerization is directly linked with TLR4-signaling.
Journal of endotoxin research 2004;10(4):257-60.
2003: Zheng-Ming Wang; Xinna Li; Ross R Cocklin; Mu Wang; Mu Wang; Koichi Fukase; Seiichi Inamura; Shoichi Kusumoto; Dipika Gupta; Roman Dziarski
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.
The Journal of biological chemistry 2003;278(49):49044-52.
2003: Rudolf Haase; Carsten J Kirschning; Andreas Sing; Percy Schröttner; Koichi Fukase; Shoichi Kusumoto; Hermann Wagner; Jürgen Heesemann; Klaus Ruckdeschel
A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4294-303.
2003: Sachiko Akashi; Shin-ichiroh Saitoh; Yasutaka Wakabayashi; Takane Kikuchi; Noriaki Takamura; Yoshinori Nagai; Yutaka Kusumoto; Koichi Fukase; Shoichi Kusumoto; Yoshiyuki Adachi; Atsushi Kosugi; Kensuke Miyake
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14.
The Journal of experimental medicine 2003;198(7):1035-42.
2003: Riyoko Tamai; Yasuyuki Asai; Masahito Hashimoto; Koichi Fukase; Shoichi Kusumoto; Hideharu Ishida; Makoto Kiso; Tomohiko Ogawa
Cell activation by monosaccharide lipid A analogues utilizing Toll-like receptor 4.
Immunology 2003;110(1):66-72.
2003: Mathias Chamaillard; Masahito Hashimoto; Yasuo Horie; Junya Masumoto; Su Qiu; Lisa Saab; Yasunori Ogura; Akiko Kawasaki; Koichi Fukase; Shoichi Kusumoto; Miguel A Valvano; Simon J Foster; Tak W Mak; Gabriel Nuñez; Naohiro Inohara
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.
Nature immunology 2003;4(7):702-7.
2003: Tomohiko Ogawa; Yasuyuki Asai; Yasuhiro Sakai; Masato Oikawa; Koichi Fukase; Yasuo Suda; Shoichi Kusumoto; Toshihide Tamura
Endotoxic and immunobiological activities of a chemically synthesized lipid A of Helicobacter pylori strain 206-1.
FEMS immunology and medical microbiology 2003;36(1-2):1-7.
2003: Naohiro Inohara; Yasunori Ogura; Ana Fontalba; Olga Gutierrez; Fernando Pons; Javier Crespo; Koichi Fukase; Seiichi Inamura; Shoichi Kusumoto; Masahito Hashimoto; Simon J Foster; Anthony P Moran; Jose L Fernandez-Luna; Gabriel Nuñez
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.
The Journal of biological chemistry 2003;278(8):5509-12.
2003: Shoichi Kusumoto; Koichi Fukase; Yoshiyuki Fukase; Mikayo Kataoka; Hiroaki Yoshizaki; Kenjiro Sato; Masato Oikawa; Yasuo Suda
Structural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogs.
Journal of endotoxin research 2003;9(6):361-6.
2002: Masahiro Wakao; Koichi Fukase; Shoichi Kusumoto
Chemical synthesis of cyclodextrins by using intramolecular glycosylation.
The Journal of organic chemistry 2002;67(23):8182-90.
2002: Hisashi Akamatsu; Koichi Fukase; Shoichi Kusumoto
New efficient route for solid-phase synthesis of benzimidazole derivatives.
Journal of combinatorial chemistry 2002;4(5):475-83.
2002: Seung-Jin Ma; Jun Hiratake; Yasushi Nakai; Minoru Izumi; Koichi Fukase; Shoichi Kusumoto; Kanzo Sakata
A direct continuous spectrophotometric assay for glycosidases with 3-nitro-2-pyridyl glycosides by tautomerization of 2-hydroxy-3-nitropyridine.
Analytical biochemistry 2002;302(2):291-7.
2002: Minoru Izumi; Koichi Fukase; Shoichi Kusumoto
TMSCl as a mild and effective source of acidic catalysis in Fischer glycosidation and use of propargyl glycoside for anomeric protection.
Bioscience, biotechnology, and biochemistry 2002;66(1):211-4.
2001: Sachiko Akashi; Yoshinori Nagai; Hirotaka Ogata; M Oikawa; Koichi Fukase; S Kusumoto; Kiyoshi Kawasaki; Masahiro Nishijima; S Hayashi; Masao Kimoto; Kensuke Miyake
Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition.
International immunology 2001;13(12):1595-9.
2000: Naoko Iida-Tanaka; Koichi Fukase; H Utsumi; Ineo Ishizuka
Conformational studies on a unique bis-sulfated glycolipid using NMR spectroscopy and molecular dynamics simulations.
European journal of biochemistry / FEBS 2000;267(23):6790-7.
2000: Ulrich Seydel; M Oikawa; Koichi Fukase; Shoichi Kusumoto; Klaus Brandenburg
Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity.
European journal of biochemistry / FEBS 2000;267(10):3032-9.
2000: Egil Lien; TK Means; Holger Heine; A Yoshimura; Shoichi Kusumoto; Koichi Fukase; Matthew J Fenton; Masato Oikawa; N Qureshi; Brian G Monks; R W Finberg; Robin R Ingalls; Douglas T Golenbock
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
The Journal of clinical investigation 2000;105(4):497-504.
1999: Yohko Kawai; Y Nakagawa; T Matuyama; Kiyoko S Akagawa; K Itagawa; Koichi Fukase; S Kusumoto; Masahiro Nishijima; I Yano
A typical bacterial ornithine-containing lipid Nalpha-(D)-[3-(hexadecanoyloxy)hexadecanoyl]-ornithine is a strong stimulant for macrophages and a useful adjuvant.
FEMS immunology and medical microbiology 1999;23(1):67-73.
1997: Koichi Fukase; K Egusa; Y Nakai; S Kusumoto
Novel oxidatively removable protecting groups and linkers for solid-phase synthesis of oligosaccharides.
Molecular diversity 1997;2(4):182-8.
1996: S Minamida; K Aoki; S Natsuka; Kaoru Omichi; Koichi Fukase; S Kusumoto; S Hase
Detection of UDP-D-xylose: alpha-D-xyloside alpha 1-->3xylosyltransferase activity in human hepatoma cell line HepG2.
Journal of biochemistry 1996;120(5):1002-6.
1995: Haruhiko Takada; Y Kawabata; R Arakaki; S Kusumoto; Koichi Fukase; Y Suda; T Yoshimura; S Kokeguchi; K Kato; T Komuro
Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities.
Infection and immunity 1995;63(1):57-65.
1994: J Toyota; Kaoru Omichi; Koichi Fukase; S Kusumoto; S Hase
Identification of trisaccharide Xyl alpha 1-->3Xyl alpha 1-->3Glc in human urine.
Bioscience, biotechnology, and biochemistry 1994;58(3):567-9.
1989: N Naruse; O Tenmyo; K Tomita; M Konishi; T Miyaki; H Kawaguchi; Koichi Fukase; T Wakamiya; T Shiba
Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.
The Journal of antibiotics 1989;42(6):837-45.
1989: D E Palmer; D F Mierke; C Pattaroni; Murray Goodman; T Wakamiya; Koichi Fukase; M Kitazawa; H Fujita; T Shiba
Interactive NMR and computer simulation studies of lanthionine-ring structures.
Biopolymers 1989;28(1):397-408.