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Patrizia Santi

Research Profile

Procedures

Physiology

Skin Absorption

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Chemistry, Pharmaceutical

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Publications

TOP 3
Silvia Pescina; Patrizia Santi; Maxim Antopolsky; Sara Nicoli; Lasse Murtomäki
Effect of iontophoresis on the in vitro trans-scleral transport of three single stranded oligonucleotides.
Fabio Marra; Sara Nicoli; Cristina Padula; Patrizia Santi
Amikacin reverse iontophoresis: optimization of in vitro extraction.
Silvia Pescina; Patrizia Santi; Cristina Padula; Pierugo Cavallini; Giulio Ferrari; Paolo Govoni; Sara Nicoli
Ex vivo models to evaluate the role of ocular melanin in trans-scleral drug delivery.

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All Publications

2013: Silvia Pescina; Patrizia Santi; Maxim Antopolsky; Sara Nicoli; Lasse Murtomäki
Effect of iontophoresis on the in vitro trans-scleral transport of three single stranded oligonucleotides.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2013;49(2):142-7.
2013: Fabio Marra; Sara Nicoli; Cristina Padula; Patrizia Santi
Amikacin reverse iontophoresis: optimization of in vitro extraction.
International journal of pharmaceutics 2013;440(2):216-20.
2012: Silvia Pescina; Patrizia Santi; Cristina Padula; Pierugo Cavallini; Giulio Ferrari; Paolo Govoni; Sara Nicoli
Ex vivo models to evaluate the role of ocular melanin in trans-scleral drug delivery.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;46(5):475-83.
2011: Silvia Pescina; Patrizia Santi; Giulio Ferrari; Sara Nicoli
Trans-scleral delivery of macromolecules.
Therapeutic delivery 2011;2(10):1331-49.
2011: Silvia Pescina; Cristina Padula; Patrizia Santi; Sara Nicoli
Effect of formulation factors on the trans-scleral iontophoretic and post-iontophoretic transports of a 40 kDa dextran in vitro.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;42(5):503-8.
2010: Cristina Padula; Chiara Ferretti; Sara Nicoli; Patrizia Santi
Combined patch containing salicylic acid and nicotinamide: role of drug interaction.
Current drug delivery 2010;7(5):415-20.
2010: Cristina Padula; Chiara Chiapponi; M T Dibari; A Deriu; Fabio Sonvico; S Barbieri; J Ollivier; Patrizia Santi
Single layer transdermal film containing lidocaine: water and lidocaine mobility determined using neutron scattering.
Journal of pharmaceutical sciences 2010;99(10):4277-84.
2010: Silvia Pescina; Giulio Ferrari; Paolo Govoni; Claudio Macaluso; Cristina Padula; Patrizia Santi; Sara Nicoli
In-vitro permeation of bevacizumab through human sclera: effect of iontophoresis application.
The Journal of pharmacy and pharmacology 2010;62(9):1189-94.
2010: Giuliana Gobbi; Elena Masselli; Cristina Micheloni; Antonio Nouvenne; Domenico Russo; Patrizia Santi; Alessandro Matteucci; Lucio Cocco; Marco Vitale; Prisco Mirandola
Hypoxia-induced down-modulation of PKCepsilon promotes trail-mediated apoptosis of tumor cells.
International journal of oncology 2010;37(3):719-29.
2010: Sara Nicoli; Marc Eeman; Magali Deleu; Eleonora Bresciani; Cristina Padula; Patrizia Santi
Effect of lipopeptides and iontophoresis on aciclovir skin delivery.
The Journal of pharmacy and pharmacology 2010;62(6):702-8.
2010: Taner Senyiğit; Fabio Sonvico; Stefano Barbieri; Ozgen Ozer; Patrizia Santi; Paolo Colombo
Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(3):368-73.
2010: Cristina Padula; Andrea Fulgoni; Patrizia Santi
In vivo stratum corneum distribution of lidocaine, assessed by tape stripping, from a new bioadhesive film.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2010;16(1):125-30.
2010: C Balaguer-Fernández; Cristina Padula; A Femenía-Font; V Merino; Patrizia Santi; A López-Castellano
Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of sumatriptan succinate.
Drug delivery 2010;17(2):83-91.
2009: Fabio Marra; Carmine Ostacolo; Sonia Laneri; Antonietta Bernardi; Antonia Sacchi; Cristina Padula; Sara Nicoli; Patrizia Santi
Synthesis, hydrolysis, and skin retention of amino acid esters of alpha-tocopherol.
Journal of pharmaceutical sciences 2009;98(7):2364-76.
2009: Cristina Padula; Sara Nicoli; Patrizia Santi
Innovative formulations for the delivery of levothyroxine to the skin.
International journal of pharmaceutics 2009;372(1-2):12-6.
2009: Sara Nicoli; Giulio Ferrari; Marinella Quarta; Claudio Macaluso; Patrizia Santi
In vitro transscleral iontophoresis of high molecular weight neutral compounds.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;36(4-5):486-92.
2009: Sara Nicoli; G Ferrari; M Quarta; Claudio Macaluso; Paolo Govoni; D Dallatana; Patrizia Santi
Porcine sclera as a model of human sclera for in vitro transport experiments: histology, SEM, and comparative permeability.
Molecular vision 2009;15():259-66.
2008: Sara Nicoli; S Bilzi; Patrizia Santi; Mino R Caira; J Li; Ruggero Bettini
Ethyl-paraben and nicotinamide mixtures: apparent solubility, thermal behavior and X-ray structure of the 1:1 co-crystal.
Journal of pharmaceutical sciences 2008;97(11):4830-9.
2008: Cristina Padula; N Campana; Patrizia Santi
Simultaneous determination of benzophenone-3, retinol and retinyl acetate in pig ear skin layers by high-performance liquid chromatography.
Biomedical chromatography : BMC 2008;22(10):1060-5.
2008: Orazio Luca Strusi; Fabio Sonvico; Ruggero Bettini; Patrizia Santi; Gaia Colombo; Pedro Barata; Ana Oliveira; Delfim Santos; Paolo Colombo
Module assemblage technology for floating systems: in vitro flotation and in vivo gastro-retention.
Journal of controlled release : official journal of the Controlled Release Society 2008;129(2):88-92.
2008: Sara Nicoli; Franca Zani; Stefania Bilzi; Ruggero Bettini; Patrizia Santi
Association of nicotinamide with parabens: effect on solubility, partition and transdermal permeation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;69(2):613-21.
2008: Cristina Padula; Alice Pappani; Patrizia Santi
In vitro permeation of levothyroxine across the skin.
International journal of pharmaceutics 2008;349(1-2):161-5.
2008: Sara Nicoli; Cristina Padula; V Aversa; B Vietti; P W Wertz; A Millet; Françoise Falson; P Govoni; Patrizia Santi
Characterization of rabbit ear skin as a skin model for in vitro transdermal permeation experiments: histology, lipid composition and permeability.
Skin pharmacology and physiology 2008;21(4):218-26.
2007: S Pedersen; Fabio Marra; Sara Nicoli; Patrizia Santi
In vitro skin permeation and retention of parabens from cosmetic formulations.
International journal of cosmetic science 2007;29(5):361-7.
2007: Cristina Padula; Sara Nicoli; Vincenzo Aversa; Paolo Colombo; Françoise Falson; Fabrice Pirot; Patrizia Santi
Bioadhesive film for dermal and transdermal drug delivery.
European journal of dermatology : EJD 2007;17(4):309-12.
2007: Cristina Padula; Sara Nicoli; Paolo Colombo; Patrizia Santi
Single-layer transdermal film containing lidocaine: modulation of drug release.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;66(3):422-8.
2007: Sara Nicoli; Patrizia Santi
Suitability of excised rabbit ear skin - fresh and frozen - for evaluating transdermal permeation of estradiol.
Drug delivery 2007;14(4):195-9.
2006: Sara Nicoli; E Penna; Cristina Padula; Paolo Colombo; Patrizia Santi
New transdermal bioadhesive film containing oxybutynin: In vitro permeation across rabbit ear skin.
International journal of pharmaceutics 2006;325(1-2):2-7.
2006: A Femenía-Font; Cristina Padula; Fabio Marra; C Balaguer-Fernández; V Merino; A López-Castellano; Sara Nicoli; Patrizia Santi
Bioadhesive monolayer film for the in vitro transdermal delivery of sumatriptan.
Journal of pharmaceutical sciences 2006;95(7):1561-9.
2006: Sara Nicoli; Patrizia Santi
Assay of amikacin in the skin by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis 2006;41(3):994-7.
2006: Elena Losi; Ruggero Bettini; Patrizia Santi; Fabio Sonvico; Gaia Colombo; Kristine Lofthus; Paolo Colombo; Nicholas A Peppas
Assemblage of novel release modules for the development of adaptable drug delivery systems.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):212-8.
2006: Sara Nicoli; Patrizia Santi
Transdermal delivery of aminoglycosides: amikacin transport and iontophoretic non-invasive monitoring.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):89-94.
2006: Alessandro Gainotti; Elena Losi; Paolo Colombo; Patrizia Santi; Fabio Sonvico; Daniela Baroni; Gina Massimo; Gaia Colombo; Pasquale Del Gaudio
The effect of residual water on antacid properties of sucralfate gel dried by microwaves.
AAPS PharmSciTech 2006;7(1):E9.
2005: Cristina Padula; Francesca Sartori; Fabio Marra; Patrizia Santi
The influence of iontophoresis on acyclovir transport and accumulation in rabbit ear skin.
Pharmaceutical research 2005;22(9):1519-24.
2005: Alessandro Gainotti; Elena Losi; Ruggero Bettini; Paolo Colombo; Fabio Sonvico; Daniela Baroni; Patrizia Santi; Gaia Colombo
Effect of residual water content on the physico-chemical properties of sucralfate dried gel obtained by microwave drying.
Drug development and industrial pharmacy 2005;31(7):645-52.
2005: P Sebastiani; Sara Nicoli; Patrizia Santi
Effect of lactic acid and iontophoresis on drug permeation across rabbit ear skin.
International journal of pharmaceutics 2005;292(1-2):119-26.
2005: Sara Nicoli; Paolo Colombo; Patrizia Santi
Release and permeation kinetics of caffeine from bioadhesive transdermal films.
The AAPS journal 2005;7(1):E218-23.
2004: C Ostacolo; Fabio Marra; Sonia Laneri; Antonia Sacchi; Sara Nicoli; Cristina Padula; Patrizia Santi
Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin.
Journal of controlled release : official journal of the Controlled Release Society 2004;99(3):403-13.
2004: Mariella Artusi; Sara Nicoli; Paolo Colombo; Ruggero Bettini; Antonia Sacchi; Patrizia Santi
Effect of chemical enhancers and iontophoresis on thiocolchicoside permeation across rabbit and human skin in vitro.
Journal of pharmaceutical sciences 2004;93(10):2431-8.
2004: Sara Nicoli; V Amoretti; Paolo Colombo; Patrizia Santi
Bioadhesive transdermal film containing caffeine.
Skin pharmacology and physiology 2004;17(3):119-23.
2004: Franca Ferrari; Daniela Cocconi; Ruggero Bettini; Ferdinando Giordano; Patrizia Santi; Michael J Tobyn; Robert Price; Paul Young; Carla Caramella; Paolo Colombo
The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer.
AAPS PharmSciTech 2004;5(4):e60.
2003: Patrizia Santi; Sara Nicoli; Gaia Colombo; Ruggero Bettini; Mariella Artusi; Silvia Rimondi; Cristina Padula; Paola Rizzo; Paolo Colombo
Post-iontophoresis transport of ibuprofen lysine across rabbit ear skin.
International journal of pharmaceutics 2003;266(1-2):69-75.
2003: Sara Nicoli; Michela Cappellazzi; Paolo Colombo; Patrizia Santi
Characterization of the permselective properties of rabbit skin during transdermal iontophoresis.
Journal of pharmaceutical sciences 2003;92(7):1482-8.
2003: Cristina Padula; Gaia Colombo; Sara Nicoli; Pier Luigi Catellani; Gina Massimo; Patrizia Santi
Bioadhesive film for the transdermal delivery of lidocaine: in vitro and in vivo behavior.
Journal of controlled release : official journal of the Controlled Release Society 2003;88(2):277-85.
2003: Gaia Colombo; Alfredo Zucchi; F Allegra; Paolo Colombo; Franca Zani; Patrizia Santi
In vitro and in vivo study of 5-methoxypsoralen skin concentration after topical application.
Skin pharmacology and applied skin physiology 2003;16(2):130-6.
2003: Gaia Colombo; Mariella Artusi; Patrizia Santi; Paolo Colombo; Ruggero Bettini; Alfredo Zucchi; Sara Nicoli
Skin permeation of 5-methoxypsoralen from topical dosage forms.
Drug development and industrial pharmacy 2003;29(2):247-51.
2003: Mariella Artusi; Patrizia Santi; Paolo Colombo; H E Junginger
Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies.
International journal of pharmaceutics 2003;250(1):203-13.
2003: Gina Massimo; Patrizia Santi; Gaia Colombo; Sara Nicoli; Franca Zani; Paolo Colombo; Ruggero Bettini
The suitability of disintegrating force kinetics for studying the effect of manufacturing parameters on spironolactone tablet properties.
AAPS PharmSciTech 2003;4(2):E17.
2002: C Sacchetti; Mariella Artusi; Patrizia Santi; Paolo Colombo
Caffeine microparticles for nasal administration obtained by spray drying.
International journal of pharmaceutics 2002;242(1-2):335-9.
2002: Ruggero Bettini; Daniela Acerbi; G Caponetti; R Musa; N Magi; Paolo Colombo; Daniela Cocconi; Patrizia Santi; Pier Luigi Catellani; P Ventura
Influence of layer position on in vitro and in vivo release of levodopa methyl ester and carbidopa from three-layer matrix tablets.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2002;53(2):227-32.
2001: Sara Nicoli; S Rimondi; Paolo Colombo; Patrizia Santi
Physical and chemical enhancement of transdermal delivery of triptorelin.
Pharmaceutical research 2001;18(11):1634-7.
2001: Alfredo Zucchi; E Raho; B Marconi; Sara Nicoli; M Santini; F Allegra; Paolo Colombo; Ruggero Bettini; Patrizia Santi
Plasma and skin concentration of 5-methoxypsoralen in psoriatic patients after oral administration.
The Journal of investigative dermatology 2001;117(2):379-82.
2001: Ruggero Bettini; Pier Luigi Catellani; Patrizia Santi; Gina Massimo; Nicholas A Peppas; Paolo Colombo
Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate.
Journal of controlled release : official journal of the Controlled Release Society 2001;70(3):383-91.
2001: Sara Nicoli; Patrizia Santi; Patrick Couvreur; Guy Couarraze; Paolo Colombo; Elias Fattal
Design of triptorelin loaded nanospheres for transdermal iontophoretic administration.
International journal of pharmaceutics 2001;214(1-2):31-5.
2000: L Maggi; Pier Luigi Catellani; Emilia Fisicaro; Patrizia Santi; Franca Zani; Gina Massimo; Paolo Colombo
Effect of drying methods on retention of moist sucralfate gel properties.
AAPS PharmSciTech 2000;1(3):E26.
2000: Gina Massimo; Pier Luigi Catellani; Patrizia Santi; R Bettini; G Vaona; A Bonfanti; L Maggi; Paolo Colombo
Disintegration propensity of tablets evaluated by means of disintegrating force kinetics.
Pharmaceutical development and technology 2000;5(2):163-9.
1999: Sonia Laneri; Antonia Sacchi; E A di Frassello; E Luraschi; P Colombo; Patrizia Santi
Ionized prodrugs of dehydroepiandrosterone for transdermal iontophoretic delivery.
Pharmaceutical research 1999;16(12):1818-24.
1999: Paolo Colombo; Ruggero Bettini; Pier Luigi Catellani; Patrizia Santi; Nicholas A Peppas
Drug volume fraction profile in the gel phase and drug release kinetics in hydroxypropylmethyl cellulose matrices containing a soluble drug.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;9(1):33-40.
1999: B Marconi; F Mancini; Paolo Colombo; F Allegra; Ferdinando Giordano; Andrea Gazzaniga; G Orecchia; Patrizia Santi
Distribution of khellin in excised human skin following iontophoresis and passive dermal transport.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):261-8.
1998: Pier Luigi Catellani; Paolo Colombo; Nicholas A Peppas; Patrizia Santi; Ruggero Bettini
Partial permselective coating adds an osmotic contribution to drug release from swellable matrixes.
Journal of pharmaceutical sciences 1998;87(6):726-31.
1998: NM Volpato; Sara Nicoli; C Laureri; Paolo Colombo; Patrizia Santi
In vitro acyclovir distribution in human skin layers after transdermal iontophoresis.
Journal of controlled release : official journal of the Controlled Release Society 1998;50(1-3):291-6.
1997: NM Volpato; Patrizia Santi; C Laureri; Paolo Colombo
Assay of acyclovir in human skin layers by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis 1997;16(3):515-20.
1997: Franca Zani; A Minutello; L Maggi; Patrizia Santi; P Mazza
Evaluation of preservative effectiveness in pharmaceutical products: the use of a wild strain of Pseudomonas cepacia.
Journal of applied microbiology 1997;83(3):322-6.
1997: Patrizia Santi; NM Volpato; Ruggero Bettini; Pier Luigi Catellani; Gina Massimo; Paolo Colombo
Transdermal iontophoresis of salmon calcitonin can reproduce the hypocalcemic effect of intravenous administration.
Farmaco (Società chimica italiana : 1989) 1997;52(6-7):445-8.
1997: Patrizia Santi; Paolo Colombo; Ruggero Bettini; Pier Luigi Catellani; A Minutello; NM Volpato
Drug reservoir composition and transport of salmon calcitonin in transdermal iontophoresis.
Pharmaceutical research 1997;14(1):63-6.
1996: A De Ascentiis; Ruggero Bettini; G Caponetti; Pier Luigi Catellani; M T Peracchia; Patrizia Santi; Paolo Colombo
Delivery of nasal powders of beta-cyclodextrin by insufflation.
Pharmaceutical research 1996;13(5):734-8.
1996: Paolo Colombo; Ruggero Bettini; M T Peracchia; Patrizia Santi
Controlled release dosage forms: from ground to space.
European journal of drug metabolism and pharmacokinetics 1996;21(2):87-91.
1995: NM Volpato; Patrizia Santi; Paolo Colombo
Iontophoresis enhances the transport of acyclovir through nude mouse skin by electrorepulsion and electroosmosis.
Pharmaceutical research 1995;12(11):1623-7.
1995: Paolo Colombo; Ruggero Bettini; G Massimo; Pier Luigi Catellani; Patrizia Santi; Nicholas A Peppas
Drug diffusion front movement is important in drug release control from swellable matrix tablets.
Journal of pharmaceutical sciences 1995;84(8):991-7.