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Yihai Cao

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TOP 3
Yihai Cao
Erythropoietin in cancer: a dilemma in risk therapy.
Lasse Dahl Jensen; Yihai Cao
Clock controls angiogenesis.
Eva Hedlund; Kayoko Hosaka; Yizhi Liu; Masabumi Shibuya; Baocun Sun; Xiaojuan Yang; Yunlong Yang; Yin Zhang; Weide Zhong; Yihai Cao
Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs.

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All Publications

2013: Yihai Cao
Erythropoietin in cancer: a dilemma in risk therapy.
Trends in endocrinology and metabolism: TEM 2013;24(4):190-9.
2013: Lasse Dahl Jensen; Yihai Cao
Clock controls angiogenesis.
Cell cycle (Georgetown, Tex.) 2013;12(3):405-8.
2013: Eva Hedlund; Kayoko Hosaka; Yizhi Liu; Masabumi Shibuya; Baocun Sun; Xiaojuan Yang; Yunlong Yang; Yin Zhang; Weide Zhong; Yihai Cao
Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(2):654-9.
2012: Fan Zhang; Liping Zhang; Shizhuang Zhang; Chaoyong Zhu; Yang Li; Yizhi Liu; Wenxin Ma; Zhongshu Tang; Bin Wang; Wai Wong; Yihai Cao; Triantafyllos Chavakis; Zhiqin Gao; Xu Hou; Lasse Jensen; Anne Klotzsche-von Ameln; Anil Kumar; Harald F Langer; Chunsik Lee; Xuri Li
Proliferative and survival effects of PUMA promote angiogenesis.
Cell reports 2012;2(5):1272-85.
2012: Renhai Cao; Patrik Andersson; Steen Dissing; Ninghan Feng; Anders J Hansen; Hong Ji; Yuping Sun; Katerina Tritsaris; Xiaojuan Yang; Yin Zhang; Yihai Cao
Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(39):15894-9.
2012: Lasse Dahl Jensen; Toste Länne; Masaki Nakamura; Eric Wahlberg; Yunlong Yang; Yin Zhang; Patrik Andersson; Lars Bräutigam; Ziquan Cao; Kayoko Hosaka; Yihai Cao
Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafish.
Cell reports 2012;2(2):231-41.
2012: Hoi Leong Xavier Wong; Renhai Cao; Yihai Cao; Kui Ming Chan; Guoxiang Jin; Zhongjun Zhou
When MT1-MMP meets ADAMs.
Cell cycle (Georgetown, Tex.) 2012;11(15):2793-8.
2012: Kui Ming Chan; Guoxiang Jin; Kaisa Lehti; Baohua Liu; Karl Tryggvason; Hoi Leong Xavier Wong; Renhai Cao; Yihai Cao; Zhongjun Zhou
MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.
Developmental cell 2012;22(6):1176-90.
2012: Sharon Lim; Takahiro Seki; Yuan Xue; Xiaojuan Yang; Patrik Andersson; Ziquan Cao; Jennifer Honek; Kayoko Hosaka; Yihai Cao
Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice.
Nature protocols 2012;7(3):606-15.
2012: Rajesh K Nallapalli; David Pazooki; Björn Redfors; Sai Naresh Sunkara; Yin Zhang; Alex X Zhou; Sashidar Bandaru; Martin O Bergo; Jan Borén; Yihai Cao; Mohamed X Ibrahim; Levent M Akyürek
Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice.
Molecular cancer 2012;11():50.
2011: Sébastien Banquet; Fabrice Bauer; Renhai Cao; Yihai Cao; Brigitte Dautreaux; Florence Edwards; Elodie Gomez; Jean-Paul Henry; Françoise Lallemand; Paul Mulder; Lionel Nicol; Vincent RICHARD; Damien Schapman; Christian Thuillez; Ebba Brakenhielm
Arteriogenic therapy by intramyocardial sustained delivery of a novel growth factor combination prevents chronic heart failure.
Circulation 2011;124(9):1059-69.
2011: Lasse Dahl Jensen; Toste Länne; Pegah Rouhi; eric wahlberg; Ziquan Cao; Yihai Cao
Zebrafish models to study hypoxia-induced pathological angiogenesis in malignant and nonmalignant diseases.
Birth defects research. Part C, Embryo today : reviews 2011;93(2):182-93.
2011: Renhai Cao; Sharon Lim; Hong Ji; Yin Zhang; Yunlong Yang; Jennifer Honek; Eva-Maria Hedlund; Yihai Cao
Mouse corneal lymphangiogenesis model.
Nature protocols 2011;6(6):817-26.
2011: Danfang Zhang; Eva-Maria E Hedlund; Sharon Lim; Fang Chen; Yin Zhang; Baocun Sun; Yihai Cao
Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(10):4117-22.
2011: Yihai Cao
Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?
The International journal of developmental biology 2011;55(4-5):557-62.
2011: Jan Kitajewski; Yihai Cao; Mark Slevin
It's hard to keep all things angiogenic in one JAR!
Vascular cell 2011;3(1):1.
2010: Pegah Rouhi; Lasse D Jensen; Ziquan Cao; Kayoko Hosaka; Toste Länne; eric wahlberg; John Fleng Steffensen; Yihai Cao
Hypoxia-induced metastasis model in embryonic zebrafish.
Nature protocols 2010;5(12):1911-8.
2010: Ziquan Cao; Lasse D Jensen; Pegah Rouhi; Kayoko Hosaka; Toste Länne; John Fleng Steffensen; eric wahlberg; Yihai Cao
Hypoxia-induced retinopathy model in adult zebrafish.
Nature protocols 2010;5(12):1903-10.
2010: Yihai Cao
Off-tumor target--beneficial site for antiangiogenic cancer therapy?
Nature reviews. Clinical oncology 2010;7(10):604-8.
2010: Cheng Zhang; Yu Xia Zhao; Yue Hui Zhang; Li Zhu; Bi Ping Deng; Zhao Li Zhou; Shu Ying Li; Xiao Ting Lu; Li Li Song; Xue Ming Lei; Wen Bo Tang; Nan Wang; Chun Ming Pan; Huai-Dong Song; Chun Xi Liu; Bo Dong; Yun Zhang; Yihai Cao
Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(36):15886-91.
2010: Xu Hou; Anil Kumar; Chunsik Lee; Bin Wang; Pachiappan Arjunan; Lijin Dong; Arvydas Maminishkis; Zhongshu Tang; Yang Li; Fan Zhang; Shi-Zhuang Zhang; Piotr Wardega; Sagarika Chakrabarty; Baoying Liu; Zhijian Wu; Peter Colosi; Robert Fariss; Johan Lennartsson; Robert Nussenblatt; J Silvio Gutkind; Yihai Cao; Xuri Li
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12216-21.
2010: Renhai Cao; Yihai Cao
Cancer-associated retinopathy: a new mechanistic insight on vascular remodeling.
Cell cycle (Georgetown, Tex.) 2010;9(10):1882-5.
2010: Yuan Xue; Sharon Lim; Ebba Brakenhielm; Yihai Cao
Adipose angiogenesis: quantitative methods to study microvessel growth, regression and remodeling in vivo.
Nature protocols 2010;5(5):912-20.
2010: Yihai Cao
Angiogenesis: What can it offer for future medicine?
Experimental cell research 2010;316(8):1304-8.
2010: Zhongshu Tang; Pachiappan Arjunan; Chunsik Lee; Yang Li; Anil Kumar; Xu Hou; Bin Wang; Piotr Wardega; Fan Zhang; Lijin Dong; Yongqing Zhang; Shi-Zhuang Zhang; Hao Ding; Robert Fariss; Kevin G Becker; Johan Lennartsson; Nobuo Nagai; Yihai Cao; Xuri Li
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
The Journal of experimental medicine 2010;207(4):867-80.
2010: Yihai Cao
Wake-up call for endothelial cells.
Blood 2010;115(12):2336-7.
2010: Yihai Cao
Therapeutic angiogenesis for ischemic disorders: what is missing for clinical benefits?
Discovery medicine 2010;9(46):179-84.
2010: Pegah Rouhi; Samantha Lin Chiou Lee; Ziquan Cao; Eva-Maria Hedlund; Lasse Dahl Jensen; Yihai Cao
Pathological angiogenesis facilitates tumor cell dissemination and metastasis.
Cell cycle (Georgetown, Tex.) 2010;9(5):913-7.
2010: Yihai Cao
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases.
Nature reviews. Drug discovery 2010;9(2):107-15.
2010: Yihai Cao; Robert Langer
Optimizing the delivery of cancer drugs that block angiogenesis.
Science translational medicine 2010;2(15):15ps3.
2010: Renhai Cao; Yuan Xue; Eva-Maria Hedlund; Zhaodong Zhong; Katerina Tritsaris; Barbara Tondelli; Franco Lucchini; Zhenping Zhu; Steen Dissing; Yihai Cao
VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):856-61.
2009: Samantha Lin Chiou Lee; Pegah Rouhi; Lasse Dahl Jensen; Danfang Zhang; Hong Ji; Giselbert Hauptmann; Philip Ingham; Yihai Cao
Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(46):19485-90.
2009: L D Jensen; Renhai Cao; Yihai Cao
In vivo angiogenesis and lymphangiogenesis models.
Current molecular medicine 2009;9(8):982-91.
2009: Yihai Cao
Monotherapy versus combination therapy of angiogenic and arteriogenic factors for the treatment of ischemic disorders.
Current molecular medicine 2009;9(8):967-72.
2009: Yihai Cao
Angiogenesis and lymphangiogenesis in common diseases. Editorial.
Current molecular medicine 2009;9(8):928.
2009: Lasse Dahl Ejby Jensen; Renhai Cao; Eva-Maria Hedlund; Iris Söll; Jon O Lundberg; Giselbert Hauptmann; John Fleng Steffensen; Yihai Cao
Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(43):18408-13.
2009: Eva-Maria Hedlund; Kayoko Hosaka; Zhaodong Zhong; Renhai Cao; Yihai Cao
Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(41):17505-10.
2009: Yihai Cao
Angiogenesis in malignancy.
Seminars in cancer biology 2009;19(5):277-8.
2009: Yihai Cao; Weide Zhong; Yan Sun
Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance.
Seminars in cancer biology 2009;19(5):338-43.
2009: Fan Zhang; Zhongshu Tang; Xu Hou; Johan Lennartsson; Yang Li; Alexander W Koch; Pierre Scotney; Chunsik Lee; Pachiappan Arjunan; Lijin Dong; Anil Kumar; Tuomas T Rissanen; Bin Wang; Nobuo Nagai; Pierre Fons; Robert Fariss; Yongqing Zhang; Eric F Wawrousek; Ginger Tansey; James Raber; Guo-Hua Fong; Hao Ding; David A Greenberg; Kevin G Becker; Jean-Marc Herbert; Andrew Nash; Seppo Yla-Herttuala; Yihai Cao; Ryan J Watts; Xuri Li
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6152-7.
2009: Yihai Cao
Positive and negative modulation of angiogenesis by VEGFR1 ligands.
Science signaling 2009;2(59):re1.
2009: Yuan Xue; Natasa Petrovic; Renhai Cao; Ola Larsson; Sharon Lim; Shaohua Chen; Helena M Feldmann; Zicai Liang; Zhenping Zhu; Jan Nedergaard; Barbara Cannon; Yihai Cao
Hypoxia-independent angiogenesis in adipose tissues during cold acclimation.
Cell metabolism 2009;9(1):99-109.
2009: Yuan Xue; Fang Chen; Danfang Zhang; Sharon Lim; Yihai Cao
Tumor-derived VEGF modulates hematopoiesis.
Journal of angiogenesis research 2009;1():9.
2009: Mark Slevin; Yihai Cao; Jan Kitajewski
Welcome to Journal of Angiogenesis Research.
Journal of angiogenesis research 2009;1():1.
2009: Yolanda Alvarez; Olaya Astudillo; Lasse Jensen; Alison Reynolds; Nora Waghorne; Derek Brazil; Yihai Cao; John J O'Connor; Breandán N Kennedy
Selective inhibition of retinal angiogenesis by targeting PI3 kinase.
PloS one 2009;4(11):e7867.
2009: Yihai Cao
Tumor angiogenesis and molecular targets for therapy.
Frontiers in bioscience : a journal and virtual library 2009;14():3962-73.
2009: Junhang Zhang; Renhai Cao; Yun Zhang; Tanghong Jia; Yihai Cao; eric wahlberg
Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(1):153-63.
2008: Yuan Xue; Piotr Religa; Renhai Cao; Anders J Hansen; Franco Lucchini; Bernt Jones; Yan Wu; Zhenping Zhu; Bronislaw Pytowski; Yuxiang Liang; Weide Zhong; Paolo Vezzoni; Björn Rozell; Yihai Cao
Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18513-8.
2008: Petra Korpisalo; Henna Karvinen; Tuomas T Rissanen; Johanna Kilpijoki; Varpu Marjomäki; Peter Baluk; Donald M McDonald; Yihai Cao; Ulf Eriksson; Kari Alitalo; Seppo Ylä-Herttuala
Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels.
Circulation research 2008;103(10):1092-9.
2008: Steven Clasper; Daniel Royston; Dilair Baban; Yihai Cao; Stephan Ewers; Stefan Butz; Dietmar Vestweber; David G Jackson
A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis.
Cancer research 2008;68(18):7293-303.
2008: Yihai Cao; Robert Langer
A review of Judah Folkman's remarkable achievements in biomedicine.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13203-5.
2008: Yuan Xue; Renhai Cao; Daniel Nilsson; Shaohua Chen; Rickard Westergren; Eva-Maria Hedlund; Cecile Martijn; Lena Rondahl; Per Krauli; Erik Walum; Sven Enerbäck; Yihai Cao
FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):10167-72.
2008: Yihai Cao; Renhai Cao; Eva-Maria Hedlund
R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways.
Journal of molecular medicine (Berlin, Germany) 2008;86(7):785-9.
2008: Yang Li; Fan Zhang; Nobuo Nagai; Zhongshu Tang; Shuihua Zhang; Pierre Scotney; Johan Lennartsson; Chaoyong Zhu; Yi Qu; Changge Fang; Jianyuan Hua; Osamu Matsuo; Guo-Hua Fong; Hao Ding; Yihai Cao; Kevin G Becker; Andrew Nash; Carl-Henrik Heldin; Xuri Li
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.
The Journal of clinical investigation 2008;118(3):913-23.
2008: Yoko Ishii; MATSUMOTO Yoshiki; Rie Watanabe; Muna Elmi; Toshihiko Fujimori; Johan Nissen; Yihai Cao; Yo-Ichi Nabeshima; Masakiyo Sasahara; Keiko Funa
Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice.
Molecular and cellular neurosciences 2008;37(3):507-18.
2008: Renhai Cao; Lasse Dahl Ejby Jensen; Iris Söll; Giselbert Hauptmann; Yihai Cao
Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathy.
PloS one 2008;3(7):e2748.
2008: Yihai Cao
Molecular mechanisms and therapeutic development of angiogenesis inhibitors.
Advances in cancer research 2008;100():113-31.
2008: Ebba Brakenhielm; Yihai Cao
Angiogenesis in adipose tissue.
Methods in molecular biology (Clifton, N.J.) 2008;456():65-81.
2008: R Liu; Xin-Wen Zhou; Heikki Tanila; C Bjorkdahl; Jian-Zhi Wang; Zhi-Zhong Guan; Yihai Cao; Jan-�ke GUSTAFSSON; Bengt Winblad; Jin-Jing Pei
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.
Journal of cellular and molecular medicine 2008;12(1):241-57.
2007: Johan Nissen; Renhai Cao; Eva-Maria Hedlund; Zongwei Wang; Xing Zhao; Daniel Wetterskog; Keiko Funa; Ebba Brakenhielm; Yihai Cao
Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis.
The Journal of clinical investigation 2007;117(10):2766-77.
2007: Yihai Cao; Weide Zhong
Tumor-derived lymphangiogenic factors and lymphatic metastasis.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2007;61(9):534-9.
2007: Katerina Tritsaris; Maja Myren; Sisse B Ditlev; Martin V Hübschmann; Ida van der Blom; Anders J Hansen; Uffe B Olsen; Renhai Cao; Junhang Zhang; Tanghong Jia; eric wahlberg; Steen Dissing; Yihai Cao
IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(39):15364-9.
2007: Yihai Cao
Angiogenesis modulates adipogenesis and obesity.
The Journal of clinical investigation 2007;117(9):2362-8.
2007: Erika Iivanainen; Ilkka Paatero; Satu-Maria Heikkinen; Teemu T Junttila; Renhai Cao; Peter Klint; Panu M Jaakkola; Yihai Cao; Klaus Elenius
Intra- and extracellular signaling by endothelial neuregulin-1.
Experimental cell research 2007;313(13):2896-909.
2007: Huixia Lu; Xinsheng Xu; Mei Zhang; Renhai Cao; Ebba Brakenhielm; Changjiang Li; Huili Lin; Guihua Yao; Huiwen Sun; Lihang Qi; Mengxiong Tang; Hongyan Dai; Yanen Zhang; Runyi Su; Yanwen Bi; Yun Zhang; Yihai Cao
Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12140-5.
2007: Xianghua Zhou; Fei Tian; Johan Sandzén; Renhai Cao; Emilie Flaberg; Laszlo Szekely; Yihai Cao; Claes Ohlsson; Martin O Bergo; Jan Borén; Levent M Akyürek
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3919-24.
2007: Yihai Cao; Qi Liu
Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis.
Advances in cancer research 2007;97():203-24.
2006: Xiaowei Zheng; Jorge Ruas; Renhai Cao; Florian A Salomons; Yihai Cao; Lorenz Poellinger; Teresa Pereira
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.
Molecular and cellular biology 2006;26(12):4628-41.
2006: Renhai Cao; Meit A Björndahl; Marta I Gallego; Shaohua Chen; Piotr Religa; Anders J Hansen; Yihai Cao
Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action.
Blood 2006;107(9):3531-6.
2006: Takuji Torimura; Takato Ueno; Motoaki Kin; Eitaro Taniguchi; Toru Nakamura; Kinya Inoue; Ryuichiro Sakata; Osamu Hashimoto; Masaharu Sakamoto; Hiromasa Ohira; Ryukichi Kumashiro; Michio Sata; Hirohisa Yano; Masamichi Kojiro; Niina Veitonmäki; Yihai Cao
Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma.
Gastroenterology 2006;130(4):1301-10.
2005: Piotr Religa; Renhai Cao; Meit Bjorndahl; Zhongjun Zhou; Zhenping Zhu; Yihai Cao
Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels.
Blood 2005;106(13):4184-90.
2005: Meit A Björndahl; Renhai Cao; Johan Nissen; Steven Clasper; Louise A Johnson; Yuan Xue; Zhongjun Zhou; David Jackson; Anders J Hansen; Yihai Cao
Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(43):15593-8.
2005: Meit A Björndahl; Renhai Cao; Jeremy B Burton; Ebba Brakenhielm; Piotr Religa; Dagmar Galter; Lily Wu; Yihai Cao
Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis.
Cancer research 2005;65(20):9261-8.
2005: Yihai Cao
Tumor angiogenesis and therapy.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2005;59 Suppl 2():S340-3.
2005: Yihai Cao
Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis.
Nature reviews. Cancer 2005;5(9):735-43.
2005: Baohua Liu; Jianming Wang; Kui Ming Chan; Wai Mui Tjia; Wen Deng; Xinyuan Guan; Jian-Dong Huang; Kai Man Li; Pui Yin Chau; David J Chen; Duanqing Pei; Alberto Pendas; Juan Cadiñanos; Carlos López-Otín; Hung-Fat Tse; Chris Hutchison; Junjie Chen; Yihai Cao; Kathryn S E Cheah; Karl Tryggvason; Zhongjun Zhou
Genomic instability in laminopathy-based premature aging.
Nature medicine 2005;11(7):780-5.
2005: Yihai Cao; An Hong; Henny Schulten; Mark J Post
Update on therapeutic neovascularization.
Cardiovascular research 2005;65(3):639-48.
2005: Yihai Cao
Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis.
Cell cycle (Georgetown, Tex.) 2005;4(2):228-30.
2004: Renhai Cao; Meit A Björndahl; Piotr Religa; Steven Clasper; Stina Garvin; Dagmar Galter; Björn Meister; Fumitaka Ikomi; Katerina Tritsaris; Steen Dissing; Toshio Ohhashi; David G Jackson; Yihai Cao
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.
Cancer cell 2004;6(4):333-45.
2004: Zhongjun Zhou; Jianming Wang; Renhai Cao; Hiroyuki Morita; Raija Soininen; Kui Ming Chan; Baohua Liu; Yihai Cao; Karl Tryggvason
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice.
Cancer research 2004;64(14):4699-702.
2004: Ebba Brakenhielm; Renhai Cao; Bihu Gao; Bo Angelin; Barbara Cannon; Paolo Parini; Yihai Cao
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice.
Circulation research 2004;94(12):1579-88.
2004: Zhongjun Zhou; Masayuki Doi; Jianming Wang; Renhai Cao; Baohua Liu; Kui Ming Chan; Jarkko Kortesmaa; Lydia Sorokin; Yihai Cao; Karl Tryggvason
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice.
Cancer research 2004;64(12):4059-63.
2004: Meit A Björndahl; Renhai Cao; Anna Eriksson; Yihai Cao
Blockage of VEGF-induced angiogenesis by preventing VEGF secretion.
Circulation research 2004;94(11):1443-50.
2004: Niina Veitonmäki; Renhai Cao; Lin-Hua Wu; Tammy L Moser; Bo Li; Salvatore V Pizzo; Boris Zhivotovsky; Yihai Cao
Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis.
Cancer research 2004;64(10):3679-86.
2004: Yihai Cao
Antiangiogenic cancer therapy.
Seminars in cancer biology 2004;14(2):139-45.
2004: Renhai Cao; Anna Eriksson; Hajime Kubo; Kari Alitalo; Yihai Cao; Johan Thyberg
Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability.
Circulation research 2004;94(5):664-70.
2004: Ebba Brakenhielm; Niina Veitonmäki; Renhai Cao; Shinji Kihara; Yuji Matsuzawa; Boris Zhivotovsky; Tohru Funahashi; Yihai Cao
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2476-81.
2004: Yihai Cao; Lexun Xue
Angiostatin.
Seminars in thrombosis and hemostasis 2004;30(1):83-93.
2003: A Jonas Ekstrand; Renhai Cao; Meit Bjorndahl; Susanne Nystrom; Ann-Cathrine Jonsson-Rylander; Hessameh Hassani; Bengt Hallberg; Margareta Nordlander; Yihai Cao
Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6033-8.
2003: Renhai Cao; Ebba Brakenhielm; Robert Pawliuk; David Wariaro; Mark J Post; eric wahlberg; Philippe Leboulch; Yihai Cao
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2.
Nature medicine 2003;9(5):604-13.
2003: Niina Veitonmäki; Jonas Fuxe; Magnus Hultdin; Göran Roos; Ralf F Pettersson; Yihai Cao
Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4A/pRb.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):764-6.
2003: Anna Eriksson; Renhai Cao; Joy Roy; Katerina Tritsaris; Claes Wahlestedt; Steen Dissing; Johan Thyberg; Yihai Cao
Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability.
Circulation 2003;107(11):1532-8.
2003: Percy F Sumariwalla; Yihai Cao; Hua-Lin Wu; Eugene Eyo Akujuru; Ewa Paleolog
The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.
Arthritis research & therapy 2003;5(1):R32-9.
2002: Yihai Cao; Renhai Cao; Niina Veitonmäki
Kringle structures and antiangiogenesis.
Current medicinal chemistry. Anti-cancer agents 2002;2(6):667-81.
2002: Hajime Kubo; Renhai Cao; Ebba Brakenhielm; Taija Mäkinen; Yihai Cao; Kari Alitalo
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8868-73.
2002: Robert Pawliuk; Thomas Bachelot; Omar Zurkiya; Anna Eriksson; Yihai Cao; Philippe Leboulch
Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(4):345-51.
2002: Anna Eriksson; Renhai Cao; Robert Pawliuk; Sanna Maria Berg; Monica Tsang; Danielle Zhou; Christina Fleet; Katerina Tritsaris; Steen Dissing; Philippe Leboulch; Yihai Cao
Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers.
Cancer cell 2002;1(1):99-108.
2002: Jill Thyboll; Jarkko Kortesmaa; Renhai Cao; Raija Soininen; Ling Wang; Antti Iivanainen; Lydia Sorokin; Mårten Risling; Yihai Cao; Karl Tryggvason
Deletion of the laminin alpha4 chain leads to impaired microvessel maturation.
Molecular and cellular biology 2002;22(4):1194-202.
2001: Ebba Brakenhielm; Renhai Cao; Yihai Cao
Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(10):1798-800.
2001: Renhai Cao; Ebba Brakenhielm; Claes Wahlestedt; J Thyberg; Yihai Cao
Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6390-5.
2000: Yihai Cao; Niina Veitonmäki; K Keough; H Cheng; L S Lee; D Zurakowski
Elevated levels of urine angiostatin and plasminogen/plasmin in cancer patients.
International journal of molecular medicine 2000;5(5):547-51.
2000: Z Zhou; S S Apte; Raija Soininen; Renhai Cao; G Y Baaklini; R W Rauser; J Wang; Yihai Cao; Karl Tryggvason
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4052-7.
1999: Renhai Cao; J Farnebo; M Kurimoto; Yihai Cao
Interleukin-18 acts as an angiogenesis and tumor suppressor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(15):2195-202.
1999: Yihai Cao
Therapeutic potentials of angiostatin in the treatment of cancer.
Haematologica 1999;84(7):643-50.
1999: Renhai Cao; H L Wu; Niina Veitonmäki; P Linden; J Farnebo; G Y Shi; Yihai Cao
Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5728-33.
1998: Yihai Cao; P Linden; J Farnebo; Renhai Cao; A Eriksson; V Kumar; Jian Hua Qi; Lena Claesson-Welsh; K Alitalo
Vascular endothelial growth factor C induces angiogenesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14389-94.
1998: Yihai Cao; Michael S O'Reilly; B Marshall; Evelyn Flynn; R W Ji; Judah Folkman
Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.
The Journal of clinical investigation 1998;101(5):1055-63.
1997: Yihai Cao; A Chen; SS An; R W Ji; D Davidson; Miguel Llinás
Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth.
The Journal of biological chemistry 1997;272(36):22924-8.
1997: Yihai Cao; W R Ji; P Qi; A Rosin; Y Cao
Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing.
Biochemical and biophysical research communications 1997;235(3):493-8.
1996: Yihai Cao; P Linden; D Shima; F Browne; Judah Folkman
In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor.
The Journal of clinical investigation 1996;98(11):2507-11.
1996: Yihai Cao; R W Ji; D Davidson; Johann Schaller; Dorothee Marti; S Söhndel; S G McCance; Michael S O'Reilly; Miguel Llinás; Judah Folkman
Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.
The Journal of biological chemistry 1996;271(46):29461-7.
1996: Yihai Cao; H Chen; L Zhou; M K Chiang; B Anand-Apte; J A Weatherbee; Y Wang; F Fang; John G Flanagan; M L Tsang
Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR.
The Journal of biological chemistry 1996;271(6):3154-62.
1995: Yihai Cao; C Chen; J A Weatherbee; M Tsang; Judah Folkman
gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.
The Journal of experimental medicine 1995;182(6):2069-77.
1994: Michael S O'Reilly; L Holmgren; Yuen Shing; C Chen; R A Rosenthal; Marsha A Moses; William Stratton Lane; Yihai Cao; E H Sage; Judah Folkman
Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.
Cell 1994;79(2):315-28.
1994: Michael S O'Reilly; L Holmgren; Yuen Shing; C Chen; R A Rosenthal; Yihai Cao; Marsha A Moses; William Stratton Lane; E H Sage; Judah Folkman
Angiostatin: a circulating endothelial cell inhibitor that suppresses angiogenesis and tumor growth.
Cold Spring Harbor symposia on quantitative biology 1994;59():471-82.