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Elisabeth Davioud

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Chemicals & Drugs

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Katharina Ehrhardt; Hangjun Ke; Michael Lanzer; Akhil B Vaidya; Elisabeth Davioud; Marcel Deponte
The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.
Didier Belorgey; Don Antoine Lanfranchi; Elisabeth Davioud
1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents.
Don Antoine Lanfranchi; David L Williams; Katja Becker; Benoît Bertrand; Elena Cesar-Rodo; Latasha Day; Mourad Elhabiri; Hsin-Hung Huang; Laure Johann; Elisabeth Davioud
Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.

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All Publications

2013: Katharina Ehrhardt; Hangjun Ke; Michael Lanzer; Akhil B Vaidya; Elisabeth Davioud; Marcel Deponte
The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.
Antimicrobial agents and chemotherapy 2013;57(5):2114-20.
2013: Didier Belorgey; Don Antoine Lanfranchi; Elisabeth Davioud
1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents.
Current pharmaceutical design 2013;19(14):2512-28.
2012: Don Antoine Lanfranchi; David L Williams; Katja Becker; Benoît Bertrand; Elena Cesar-Rodo; Latasha Day; Mourad Elhabiri; Hsin-Hung Huang; Laure Johann; Elisabeth Davioud
Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.
Organic & biomolecular chemistry 2012;10(31):6375-87.
2012: Olga Blank; Elisabeth Davioud; Mourad Elhabiri
Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study.
Antioxidants & redox signaling 2012;17(4):544-54.
2012: Sibylle Haid; Thierry Hennebelle; Céline Hernandez; Beate Jannack; Oliver T Keppler; Matthieu Lemasson; Alexandra Novodomská; François Bailleul; Dorothea Bankwitz; Ralf Bartenschlager; Patrick Chhatwal; Elisabeth Davioud; Juliane Gentzsch; Silvia Geuenich; Christina Grethe; Marion Poenisch; Arielle R Rosenberg; Flossie Wong-Staal; Thomas Pietschmann
A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.
Gastroenterology 2012;143(1):213-22.e5.
2012: Don Antoine Lanfranchi; Michael Lanzer; Tobias Müller; Hervé Vezin; Didier Belorgey; Elisabeth Davioud
Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase.
Organic & biomolecular chemistry 2012;10(24):4795-806.
2012: Laure Johann; Don Antoine Lanfranchi; Elisabeth Davioud; Mourad Elhabiri
A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs.
Current pharmaceutical design 2012;18(24):3539-66.
2011: Tobias Müller; Cecilia Sanchez; R Heiner Schirmer; Joseph Schrével; Vanessa Yardley; Christiane Deregnaucourt; Beate Jannack; Laure Johann; Don Antoine Lanfranchi; Michael Lanzer; Holger Bauer; Margit Brückner; Elisabeth Davioud
Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites.
Journal of the American Chemical Society 2011;133(30):11557-71.
2010: Nicole I Wenzel; Natascha Chavain; Yulin Wang; Wolfgang Friebolin; Louis Maes; Bruno Pradines; Michael Lanzer; Vanessa Yardley; Reto Brun; Christel Herold-Mende; Christophe Biot; Katalin Tóth; Elisabeth Davioud
Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA.
Journal of medicinal chemistry 2010;53(8):3214-26.
2009: Natascha Chavain; Elisabeth Davioud; Xavier Trivelli; Linda Mbeki; Matthias Rottmann; Reto Brun; christophe biot
Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker.
Bioorganic & medicinal chemistry 2009;17(23):8048-59.
2009: I Nicole Wenzel; Pui E Wong; Louis Maes; Thomas J J Müller; R Luise Krauth-Siegel; Michael P Barrett; Elisabeth Davioud
Unsaturated Mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains.
ChemMedChem 2009;4(3):339-51.
2008: Elodie Viry; Eric Battaglia; Valérie Deborde; Tobias Müller; Régis Réau; Elisabeth Davioud; Denyse Bagrel
A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells.
ChemMedChem 2008;3(11):1667-70.
2008: Christophe Morin; Tatiana Besset; Jean-Claude Moutet; Martine Fayolle; Margit Brückner; Danièle Limosin; Katja Becker; Elisabeth Davioud
The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase.
Organic & biomolecular chemistry 2008;6(15):2731-42.
2008: Wolfgang Friebolin; Beate Jannack; Nicole Wenzel; Julien Furrer; Thomas Oeser; Cecilia P Sanchez; Michael Lanzer; Vanessa Yardley; Katja Becker; Elisabeth Davioud
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.
Journal of medicinal chemistry 2008;51(5):1260-77.
2007: Angela N Kuntz; Elisabeth Davioud; Ahmed A Sayed; Lindsay L Califf; Jean Dessolin; Elias Arnér; David L Williams
Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.
PLoS medicine 2007;4(6):e206.
2006: Holger Bauer; Karin Fritz-Wolf; Andreas Winzer; Sebastian Kühner; Susan Little; Vanessa Yardley; Hervé Vezin; Bruce A Palfey; R Heiner Schirmer; Elisabeth Davioud
A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme.
Journal of the American Chemical Society 2006;128(33):10784-94.
2006: Adriano D Andricopulo; M B Akoachere; R Krogh; C Nickel; Michael McLeish; George L Kenyon; L David Arscott; Charles H Williams; Elisabeth Davioud; Katja Becker
Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents.
Bioorganic & medicinal chemistry letters 2006;16(8):2283-92.
2006: Sabine Urig; Karin Fritz-Wolf; Régis Réau; Christel Herold-Mende; Katalin Tóth; Elisabeth Davioud; Katja Becker
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases.
Angewandte Chemie (International ed. in English) 2006;45(12):1881-6.
2005: Brittany Lee; Holger Bauer; Johannes Melchers; Thomas Ruppert; Lauren Rattray; Vanessa Yardley; Elisabeth Davioud; R Luise Krauth-Siegel
Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.
Journal of medicinal chemistry 2005;48(23):7400-10.
2005: Régis Millet; Sabine Urig; Judit Jacob; Eberhard Amtmann; Jacques-Philippe Moulinoux; Stephan Gromer; Katja Becker; Elisabeth Davioud
Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors.
Journal of medicinal chemistry 2005;48(22):7024-39.
2005: Marcel Deponte; Sabine Urig; L David Arscott; Karin Fritz-Wolf; Régis Réau; Christel Herold-Mende; Sasa Koncarevic; Markus Meyer; Elisabeth Davioud; David P Ballou; Charles H Williams; Katja Becker
Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase.
The Journal of biological chemistry 2005;280(21):20628-37.
2004: christophe biot; Holger Bauer; R Heiner Schirmer; Elisabeth Davioud
5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials.
Journal of medicinal chemistry 2004;47(24):5972-83.
2003: Elisabeth Davioud; Michael McLeish; Donna M Veine; David Giegel; L David Arscott; Adriano D Andricopulo; Katja Becker; Sylke Müller; R Heiner Schirmer; Charles H Williams; George L Kenyon
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity.
Biochemistry 2003;42(45):13319-30.
2003: Laurent Soulère; Patrick Delplace; Elisabeth Davioud; Sandrine Py; Christian Sergheraert; Jacques Périé; Isabelle Ricard; Pascal Hoffmann; Daniel Dive
Screening of Plasmodium falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays.
Bioorganic & medicinal chemistry 2003;11(23):4941-4.
2003: christophe biot; Jean Dessolin; Philippe Grellier; Elisabeth Davioud
Double-drug development against antioxidant enzymes from Plasmodium falciparum.
Redox report : communications in free radical research 2003;8(5):280-3.
2002: Régis Millet; Louis Maes; Valérie Landry; Christian Sergheraert; Elisabeth Davioud
Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.
Bioorganic & medicinal chemistry letters 2002;12(24):3601-4.
2002: A Geoffrey Skillman; Karl W Maurer; Diana C Roe; Margaret J Stauber; Dolan Eargle; Todd J A Ewing; Angelika Muscate; Elisabeth Davioud; Maxine V Medaglia; Robert J Fisher; Eddy Arnold; Hong Qiang Gao; Robert W Buckheit; Paul L Boyer; Stephen H Hughes; Irwin D Kuntz; George L Kenyon
A novel mechanism for inhibition of HIV-1 reverse transcriptase.
Bioorganic chemistry 2002;30(6):443-58.
2002: Sandrine Vendeville; Filip Goossens; Marie-Ange Debreu-Fontaine; Valérie Landry; Elisabeth Davioud; Philippe Grellier; Simon Scharpe; Christian Sergheraert
Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases.
Bioorganic & medicinal chemistry 2002;10(6):1719-29.
2001: Philippe Grellier; Sandrine Vendeville; Roger Joyeau; Izabela M D Bastos; Hervé Drobecq; François Frappier; Antonio R L Teixeira; Joseph Schrével; Elisabeth Davioud; Christian Sergheraert; Jaime M Santana
Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes.
The Journal of biological chemistry 2001;276(50):47078-86.
2001: Elisabeth Davioud; S Delarue; christophe biot; B Schwöbel; C C Boehme; A Müssigbrodt; Louis Maes; Christian Sergheraert; Philippe Grellier; R Heiner Schirmer; Katja Becker
A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.
Journal of medicinal chemistry 2001;44(24):4268-76.
2001: Jean Dessolin; christophe biot; Elisabeth Davioud
Bromination studies of the 2,3-dimethylnaphthazarin core allowing easy access to naphthazarin derivatives.
The Journal of organic chemistry 2001;66(16):5616-9.
2001: Sophie Girault; Philippe Grellier; A Berecibar; Louis Maes; P Lemière; Elisabeth Mouray; Elisabeth Davioud; Christian Sergheraert
Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers.
Journal of medicinal chemistry 2001;44(11):1658-65.
2001: L Salmon-Chemin; E Buisine; Vanessa Yardley; S Kohler; MA Debreu; Valérie Landry; Christian Sergheraert; S L Croft; R Luise Krauth-Siegel; Elisabeth Davioud
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.
Journal of medicinal chemistry 2001;44(4):548-65.
2000: C Glineur; Elisabeth Davioud; B Vandenbunder
The conserved redox-sensitive cysteine residue of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein.
The Biochemical journal 2000;352 Pt 2():583-91.
2000: Sophie Girault; Philippe Grellier; A Berecibar; Louis Maes; Elisabeth Mouray; P Lemière; MA Debreu; Elisabeth Davioud; Christian Sergheraert
Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker.
Journal of medicinal chemistry 2000;43(14):2646-54.
2000: L Salmon-Chemin; A Lemaire; S De Freitas; B Deprez; Christian Sergheraert; Elisabeth Davioud
Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.
Bioorganic & medicinal chemistry letters 2000;10(7):631-5.
2000: B Bonnet; D Soullez; Sophie Girault; Louis Maes; Valérie Landry; Elisabeth Davioud; Christian Sergheraert
Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series.
Bioorganic & medicinal chemistry 2000;8(1):95-103.
1999: Elisabeth Davioud; A Berecibar; Sophie Girault; Valérie Landry; Hervé Drobecq; Christian Sergheraert
Synthesis of polyamine derivatives for the preparation of affinity chromatography columns for the search of new Trypanosoma cruzi targets.
Bioorganic & medicinal chemistry letters 1999;9(11):1567-72.
1999: Elisabeth Davioud; Katja Becker; Valérie Landry; Stephan Gromer; C Logé; Christian Sergheraert
Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening.
Analytical biochemistry 1999;268(1):1-8.
1999: Sandrine Vendeville; L Bourel; Elisabeth Davioud; Philippe Grellier; B Deprez; Christian Sergheraert
Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(3):437-42.
1999: F Montrichard; F Le Guen; D L Laval-Martin; Elisabeth Davioud
Evidence for the co-existence of glutathione reductase and trypanothione reductase in the non-trypanosomatid Euglenozoa: Euglena gracilis Z.
FEBS letters 1999;442(1):29-33.
1998: Jérôme Fagart; B Couette; Anny Souque; Elisabeth Davioud; Andrée Marquet; Marie-Edith Rafestin-Oblin
Photoaffinity labelling of the human mineralocorticoid receptor with steroids having a reactive group at position 3, 18 or 21.
Biochimica et biophysica acta 1998;1388(1):35-44.
1998: Elisabeth Davioud; Annie Piffeteau; C Delorme; S Coustal; Andrée Marquet
18-Vinyldeoxycorticosterone: a potent inhibitor of the bovine cytochrome P-450(11) beta.
Bioorganic & medicinal chemistry 1998;6(10):1781-8.
1998: Sophie Girault; Elisabeth Davioud; L Salmon; A Berecibar; MA Debreu; Christian Sergheraert
Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.
Bioorganic & medicinal chemistry letters 1998;8(10):1175-80.
1998: L Salmon; Valérie Landry; Oleg Melnyk; Louis Maes; Christian Sergheraert; Elisabeth Davioud
A general approach to the synthesis of polyamine linked-monoindolylmaleimides, a new series of trypanothione reductase inhibitors.
Chemical & pharmaceutical bulletin 1998;46(4):707-10.
1997: B Bonnet; D Soullez; Elisabeth Davioud; Valérie Landry; D Horvath; Christian Sergheraert
New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase.
Bioorganic & medicinal chemistry 1997;5(7):1249-56.
1997: Mireille Moutiez; Eric Quemeneur; Christian Sergheraert; V Lucas; A Tartar; Elisabeth Davioud
Glutathione-dependent activities of Trypanosoma cruzi p52 makes it a new member of the thiol:disulphide oxidoreductase family.
The Biochemical journal 1997;322 ( Pt 1)():43-8.
1996: Elisabeth Davioud; Jérôme Fagart; Anny Souque; Marie-Edith Rafestin-Oblin; Andrée Marquet
New steroidal diazo ketones as potential photoaffinity labeling reagents for the mineralocorticoid receptor: synthesis and biological activities.
Journal of medicinal chemistry 1996;39(14):2860-4.
1995: Anny Souque; Jérôme Fagart; B Couette; Elisabeth Davioud; Franck Sobrio; Andrée Marquet; Marie-Edith Rafestin-Oblin
The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent.
Endocrinology 1995;136(12):5651-8.
1993: Elisabeth Davioud; P Schambel; A Viger; Andrée Marquet
An improved synthesis of 18-norandrost-4-ene-3,17-dione.
Steroids 1993;58(3):141-4.
1988: Elisabeth Davioud; F Bailleul
Iridoids of Randia ruiziana.
Planta medica 1988;54(1):87.
1985: Elisabeth Davioud; F Bailleul; P Delaveau; H Jacquemin
Iridoids of guyanese species of stigmaphyllon.
Planta medica 1985;51(1):78.