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Michael Caparon

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Publications

TOP 3
Michael E Watson; Scott J Hultgren; Hailyn V Nielsen; Michael G Caparon
Murine Vaginal Colonization Model for Investigating Asymptomatic Mucosal Carriage of Streptococcus pyogenes.
Zachary Cusumano; Michael G Caparon
Adaptive evolution of the Streptococcus pyogenes regulatory aldolase LacD.1.
Pascale S Guiton; Thomas J Hannan; Michael G Caparon; Bradley Ford; Scott J Hultgren
Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections.

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All Publications

2013: Michael E Watson; Scott J Hultgren; Hailyn V Nielsen; Michael G Caparon
Murine Vaginal Colonization Model for Investigating Asymptomatic Mucosal Carriage of Streptococcus pyogenes.
Infection and immunity 2013;81(5):1606-17.
2013: Zachary Cusumano; Michael G Caparon
Adaptive evolution of the Streptococcus pyogenes regulatory aldolase LacD.1.
Journal of bacteriology 2013;195(6):1294-304.
2013: Pascale S Guiton; Thomas J Hannan; Michael G Caparon; Bradley Ford; Scott J Hultgren
Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections.
Infection and immunity 2013;81(1):329-39.
2012: Luis Alberto Vega; Michael G Caparon
Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal.
Molecular microbiology 2012;85(6):1119-32.
2012: Pascale S Guiton; Zhenfu Han; Jeffrey P Henderson; Michael G Caparon; Corinne K Cusumano; Karen W Dodson; James Janetka; Kimberly A Kline; Scott J Hultgren
Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.
Antimicrobial agents and chemotherapy 2012;56(9):4738-45.
2012: Hailyn V Nielsen; Staffan Normark; Jerome S Pinkner; Gary C Port; Michael G Caparon; Pascale S Guiton; Birgitta Henriques Normark; Kimberly A Kline; Fabrice Neiers; Scott J Hultgren
The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection.
mBio 2012;3(4):e00177-12.
2011: Justin B Sperry; Craig L Smith; Michael G Caparon; Tom Ellenberger; Michael L Gross
Mapping the protein-protein interface between a toxin and its cognate antitoxin from the bacterial pathogen Streptococcus pyogenes.
Biochemistry 2011;50(19):4038-45.
2011: Craig L Smith; Joydeep Ghosh; Jennifer Stine Elam; Jerome S Pinkner; Scott J Hultgren; Michael G Caparon; Tom Ellenberger
Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin.
Structure (London, England : 1993) 2011;19(2):192-202.
2011: Colin C Kietzman; Michael G Caparon
Distinct time-resolved roles for two catabolite-sensing pathways during Streptococcus pyogenes infection.
Infection and immunity 2011;79(2):812-21.
2010: Pascale S Guiton; Chia S Hung; Lynn E Hancock; Michael G Caparon; Scott J Hultgren
Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections.
Infection and immunity 2010;78(10):4166-75.
2010: David J Riddle; Debra E Bessen; Michael G Caparon
Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism.
Journal of bacteriology 2010;192(14):3735-46.
2010: Song Ok Kang; Michael G Caparon; Kyu Hong Cho
Virulence gene regulation by CvfA, a putative RNase: the CvfA-enolase complex in Streptococcus pyogenes links nutritional stress, growth-phase control, and virulence gene expression.
Infection and immunity 2010;78(6):2754-67.
2010: Kimberly A Kline; Karen W Dodson; Michael G Caparon; Scott J Hultgren
A tale of two pili: assembly and function of pili in bacteria.
Trends in microbiology 2010;18(5):224-32.
2010: N'Goundo Magassa; Sukantha Chandrasekaran; Michael G Caparon
Streptococcus pyogenes cytolysin-mediated translocation does not require pore formation by streptolysin O.
EMBO reports 2010;11(5):400-5.
2010: Kimberly A Kline; Molly A Ingersoll; Hailyn V Nielsen; Türkan Sakinc; Birgitta Henriques Normark; Sören Gatermann; Michael G Caparon; Scott J Hultgren
Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence.
Infection and immunity 2010;78(5):1943-51.
2010: Joydeep Ghosh; Patricia J Anderson; Sukantha Chandrasekaran; Michael G Caparon
Characterization of Streptococcus pyogenes beta-NAD+ glycohydrolase: re-evaluation of enzymatic properties associated with pathogenesis.
The Journal of biological chemistry 2010;285(8):5683-94.
2010: Colin C Kietzman; Michael G Caparon
CcpA and LacD.1 affect temporal regulation of Streptococcus pyogenes virulence genes.
Infection and immunity 2010;78(1):241-52.
2009: Ada Lin; Jennifer A Loughman; Bernd Heinrich Zinselmeyer; Mark J Miller; Michael G Caparon
Streptolysin S inhibits neutrophil recruitment during the early stages of Streptococcus pyogenes infection.
Infection and immunity 2009;77(11):5190-201.
2009: Pascale S Guiton; Chia S Hung; Kimberly A Kline; Robyn Roth; Andrew L Kau; Ericka Hayes; John Edward Heuser; Karen W Dodson; Michael G Caparon; Scott J Hultgren
Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development.
Infection and immunity 2009;77(9):3626-38.
2009: Benjamin F Weston; Audrey Brenot; Michael G Caparon
The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence.
Infection and immunity 2009;77(7):2840-8.
2009: Kimberly A Kline; Andrew L Kau; Swaine L Chen; Adeline Lim; Jerome S Pinkner; Jason W Rosch; Sreedhar R Nallapareddy; Barbara E Murray; Birgitta Henriques Normark; Wandy Beatty; Michael G Caparon; Scott J Hultgren
Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis.
Journal of bacteriology 2009;191(10):3237-47.
2008: Kyu Hong Cho; Michael G Caparon
tRNA modification by GidA/MnmE is necessary for Streptococcus pyogenes virulence: a new strategy to make live attenuated strains.
Infection and immunity 2008;76(7):3176-86.
2008: Jason W Rosch; Luis Alberto Vega; John M Beyer; Ada Lin; Michael G Caparon
The signal recognition particle pathway is required for virulence in Streptococcus pyogenes.
Infection and immunity 2008;76(6):2612-9.
2007: Jason N Cole; J Andrew Aquilina; Peter G Hains; Anna Henningham; Kadaba S Sriprakash; Michael G Caparon; Victor Nizet; Malak Kotb; Stuart J Cordwell; Steven P Djordjevic; Mark J Walker
Role of group A Streptococcus HtrA in the maturation of SpeB protease.
Proteomics 2007;7(24):4488-98.
2007: Jennifer A Loughman; Michael G Caparon
Comparative functional analysis of the lac operons in Streptococcus pyogenes.
Molecular microbiology 2007;64(2):269-80.
2007: Audrey Brenot; Benjamin F Weston; Michael G Caparon
A PerR-regulated metal transporter (PmtA) is an interface between oxidative stress and metal homeostasis in Streptococcus pyogenes.
Molecular microbiology 2007;63(4):1185-96.
2007: Jason W Rosch; Fong-Fu Hsu; Michael G Caparon
Anionic lipids enriched at the ExPortal of Streptococcus pyogenes.
Journal of bacteriology 2007;189(3):801-6.
2007: Jennifer A Loughman; Michael G Caparon
Contribution of invariant residues to the function of Rgg family transcription regulators.
Journal of bacteriology 2007;189(2):650-5.
2006: Jennifer A Loughman; Michael G Caparon
A novel adaptation of aldolase regulates virulence in Streptococcus pyogenes.
The EMBO journal 2006;25(22):5414-22.
2006: Joydeep Ghosh; Michael G Caparon
Specificity of Streptococcus pyogenes NAD(+) glycohydrolase in cytolysin-mediated translocation.
Molecular microbiology 2006;62(4):1203-14.
2006: Jennifer A Loughman; Michael G Caparon
Regulation of SpeB in Streptococcus pyogenes by pH and NaCl: a model for in vivo gene expression.
Journal of bacteriology 2006;188(2):399-408.
2005: Michael A Meehl; Jerome S Pinkner; Patricia Anderson; Scott J Hultgren; Michael G Caparon
A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase.
PLoS pathogens 2005;1(4):e35.
2005: Jason W Rosch; Michael G Caparon
The ExPortal: an organelle dedicated to the biogenesis of secreted proteins in Streptococcus pyogenes.
Molecular microbiology 2005;58(4):959-68.
2005: Kyu Hong Cho; Michael G Caparon
Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes.
Molecular microbiology 2005;57(6):1545-56.
2005: Andrew L Kau; Steven M Martin; William R Lyon; Ericka Hayes; Michael G Caparon; Scott J Hultgren
Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice.
Infection and immunity 2005;73(4):2461-8.
2005: Audrey Brenot; Katherine Y King; Michael G Caparon
The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes.
Molecular microbiology 2005;55(1):221-34.
2004: Jason W Rosch; Michael G Caparon
A microdomain for protein secretion in Gram-positive bacteria.
Science (New York, N.Y.) 2004;304(5676):1513-5.
2004: Michael A Meehl; Michael G Caparon
Specificity of streptolysin O in cytolysin-mediated translocation.
Molecular microbiology 2004;52(6):1665-76.
2004: Patrik Nyberg; Takao Sakai; Kyu Hong Cho; Michael G Caparon; Reinhard Fässler; Lars Björck
Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes.
The EMBO journal 2004;23(10):2166-74.
2004: William R Lyon; Michael G Caparon
Role for serine protease HtrA (DegP) of Streptococcus pyogenes in the biogenesis of virulence factors SpeB and the hemolysin streptolysin S.
Infection and immunity 2004;72(3):1618-25.
2004: Audrey Brenot; Katherine Y King; Blythe Janowiak; Owen Griffith; Michael G Caparon
Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes.
Infection and immunity 2004;72(1):408-13.
2003: Melody N Neely; William R Lyon; Donna L Runft; Michael G Caparon
Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes.
Journal of bacteriology 2003;185(17):5166-74.
2003: William R Lyon; Michael G Caparon
Trigger factor-mediated prolyl isomerization influences maturation of the Streptococcus pyogenes cysteine protease.
Journal of bacteriology 2003;185(12):3661-7.
2002: Melody N Neely; John D Pfeifer; Michael G Caparon
Streptococcus-zebrafish model of bacterial pathogenesis.
Infection and immunity 2002;70(7):3904-14.
2002: Carmela M Gibson; Michael G Caparon
Alkaline phosphatase reporter transposon for identification of genes encoding secreted proteins in gram-positive microorganisms.
Applied and environmental microbiology 2002;68(2):928-32.
2001: William R Lyon; J C Madden; J C Levin; J L Stein; Michael G Caparon
Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes.
Molecular microbiology 2001;42(1):145-57.
2001: J C Madden; N Ruiz; Michael G Caparon
Cytolysin-mediated translocation (CMT): a functional equivalent of type III secretion in gram-positive bacteria.
Cell 2001;104(1):143-52.
2000: Katherine Y King; J A Horenstein; Michael G Caparon
Aerotolerance and peroxide resistance in peroxidase and PerR mutants of Streptococcus pyogenes.
Journal of bacteriology 2000;182(19):5290-9.
2000: C M Gibson; T Mallett; Al Claiborne; Michael G Caparon
Contribution of NADH oxidase to aerobic metabolism of Streptococcus pyogenes.
Journal of bacteriology 2000;182(2):448-55.
1998: William R Lyon; C M Gibson; Michael G Caparon
A role for trigger factor and an rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes.
The EMBO journal 1998;17(21):6263-75.
1998: N Ruiz; B Wang; A Pentland; Michael G Caparon
Streptolysin O and adherence synergistically modulate proinflammatory responses of keratinocytes to group A streptococci.
Molecular microbiology 1998;27(2):337-46.
1997: G C Fogg; Michael G Caparon
Constitutive expression of fibronectin binding in Streptococcus pyogenes as a result of anaerobic activation of rofA.
Journal of bacteriology 1997;179(19):6172-80.
1997: B Wang; N Ruiz; A Pentland; Michael G Caparon
Keratinocyte proinflammatory responses to adherent and nonadherent group A streptococci.
Infection and immunity 1997;65(6):2119-26.
1996: C M Gibson; Michael G Caparon
Insertional inactivation of Streptococcus pyogenes sod suggests that prtF is regulated in response to a superoxide signal.
Journal of bacteriology 1996;178(15):4688-95.
1996: J Jaffe; S Natanson-Yaron; Michael G Caparon; Emanuel Hanski
Protein F2, a novel fibronectin-binding protein from Streptococcus pyogenes, possesses two binding domains.
Molecular microbiology 1996;21(2):373-84.
1996: V Ozeri; A Tovi; I Burstein; S Natanson-Yaron; Michael G Caparon; K M Yamada; S K Akiyama; I Vlodavsky; Emanuel Hanski
A two-domain mechanism for group A streptococcal adherence through protein F to the extracellular matrix.
The EMBO journal 1996;15(5):989-98.
1996: J Y Lee; Michael G Caparon
An oxygen-induced but protein F-independent fibronectin-binding pathway in Streptococcus pyogenes.
Infection and immunity 1996;64(2):413-21.
1995: B M Kihlberg; J Cooney; Michael G Caparon; Arne Olsén; Lars Björck
Biological properties of a Streptococcus pyogenes mutant generated by Tn916 insertion in mga.
Microbial pathogenesis 1995;19(5):299-315.
1995: S Natanson; S Sela; Allon E Moses; J M Musser; Michael G Caparon; Emanuel Hanski
Distribution of fibronectin-binding proteins among group A streptococci of different M types.
The Journal of infectious diseases 1995;171(4):871-8.
1995: N Okada; M K Liszewski; J P Atkinson; Michael G Caparon
Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2489-93.
1995: J Perez-Casal; N Okada; Michael G Caparon; June R Scott
Role of the conserved C-repeat region of the M protein of Streptococcus pyogenes.
Molecular microbiology 1995;15(5):907-16.
1995: C Gibson; G Fogg; N Okada; R T Geist; Emanuel Hanski; Michael G Caparon
Regulation of host cell recognition in Streptococcus pyogenes.
Developments in biological standardization 1995;85():137-44.
1995: Emanuel Hanski; G Fogg; A Tovi; N Okada; I Burstein; Michael G Caparon
Molecular analysis of Streptococcus pyogenes adhesion.
Methods in enzymology 1995;253():269-305.
1994: N Okada; A P Pentland; Per Falk; Michael G Caparon
M protein and protein F act as important determinants of cell-specific tropism of Streptococcus pyogenes in skin tissue.
The Journal of clinical investigation 1994;94(3):965-77.
1994: G C Fogg; C M Gibson; Michael G Caparon
The identification of rofA, a positive-acting regulatory component of prtF expression: use of an m gamma delta-based shuttle mutagenesis strategy in Streptococcus pyogenes.
Molecular microbiology 1994;11(4):671-84.
1994: Per Falk; Thomas Borén; D Haslam; Michael G Caparon
Bacterial adhesion and colonization assays.
Methods in cell biology 1994;45():165-92.
1993: R T Geist; N Okada; Michael G Caparon
Analysis of Streptococcus pyogenes promoters by using novel Tn916-based shuttle vectors for the construction of transcriptional fusions to chloramphenicol acetyltransferase.
Journal of bacteriology 1993;175(23):7561-70.
1993: S Sela; A Aviv; A Tovi; I Burstein; Michael G Caparon; Emanuel Hanski
Protein F: an adhesin of Streptococcus pyogenes binds fibronectin via two distinct domains.
Molecular microbiology 1993;10(5):1049-55.
1993: T VanHeyningen; G Fogg; D Yates; Emanuel Hanski; Michael G Caparon
Adherence and fibronectin binding are environmentally regulated in the group A streptococci.
Molecular microbiology 1993;9(6):1213-22.
1993: Scott J Hultgren; S Abraham; Michael G Caparon; Per Falk; Joseph W St Geme; Staffan Normark
Pilus and nonpilus bacterial adhesins: assembly and function in cell recognition.
Cell 1993;73(5):887-901.
1993: N Okada; R T Geist; Michael G Caparon
Positive transcriptional control of mry regulates virulence in the group A streptococcus.
Molecular microbiology 1993;7(6):893-903.
1992: Emanuel Hanski; P A Horwitz; Michael G Caparon
Expression of protein F, the fibronectin-binding protein of Streptococcus pyogenes JRS4, in heterologous streptococcal and enterococcal strains promotes their adherence to respiratory epithelial cells.
Infection and immunity 1992;60(12):5119-25.
1992: Michael G Caparon; R T Geist; J Perez-Casal; June R Scott
Environmental regulation of virulence in group A streptococci: transcription of the gene encoding M protein is stimulated by carbon dioxide.
Journal of bacteriology 1992;174(17):5693-701.
1992: J Perez-Casal; Michael G Caparon; June R Scott
Introduction of the emm6 gene into an emm-deleted strain of Streptococcus pyogenes restores its ability to resist phagocytosis.
Research in microbiology 1992;143(6):549-58.
1992: Emanuel Hanski; Michael G Caparon
Protein F, a fibronectin-binding protein, is an adhesin of the group A streptococcus Streptococcus pyogenes.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6172-6.
1991: Michael G Caparon; David S Stephens; Arne Olsén; June R Scott
Role of M protein in adherence of group A streptococci.
Infection and immunity 1991;59(5):1811-7.
1991: J Perez-Casal; Michael G Caparon; June R Scott
Mry, a trans-acting positive regulator of the M protein gene of Streptococcus pyogenes with similarity to the receptor proteins of two-component regulatory systems.
Journal of bacteriology 1991;173(8):2617-24.
1989: Michael G Caparon; June R Scott
Excision and insertion of the conjugative transposon Tn916 involves a novel recombination mechanism.
Cell 1989;59(6):1027-34.
1989: M Norgren; Michael G Caparon; June R Scott
A method for allelic replacement that uses the conjugative transposon Tn916: deletion of the emm6.1 allele in Streptococcus pyogenes JRS4.
Infection and immunity 1989;57(12):3846-50.
1988: June R Scott; P A Kirchman; Michael G Caparon
An intermediate in transposition of the conjugative transposon Tn916.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(13):4809-13.
1987: Michael G Caparon; June R Scott
Identification of a gene that regulates expression of M protein, the major virulence determinant of group A streptococci.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8677-81.